Sample analyzer, optical detection device

Abstract

The present invention provides a sample analyzer and an optical detection device. The optical detection device includes an optical substrate, a sheath flow cell module, a laser module, a forward scattered light receiving module, a lateral scattered light focusing mirror, a lateral spectroscopic module, a lateral scattered light receiving module, and a fluorescence receiving module. The sheath flow cell module is disposed on the optical substrate. The laser module is disposed on a light source substrate and located on a first side of the sheath flow cell module for providing laser light to the sheath flow cell module. The forward scattered light receiving module is disposed on a side of the sheath flow cell module away from the laser module. The lateral scattered light focusing mirror is disposed on a second side of the sheath flow cell module. The lateral spectroscopic module is disposed on a side of the lateral scattered light focusing mirror away from the sheath flow cell module. The lateral scattered light receiving module is disposed on a first side of the lateral spectroscopic module. The fluorescence receiving module is disposed on a second side of the lateral spectroscopic module. The fluorescence receiving module includes an adjustment mechanism and a fluorescence receiver arranged side by side or in a stacked manner.

Description

Technical Field

[0001] The present invention relates to the technical field of medical detection and analysis, and particularly to a sample analyzer and an optical detection device. Background Art

[0002] Due to its fast measurement speed, high accuracy, and small consumption of reagents, the fully automatic analyzer has now been widely used in hospitals at all levels, medical testing laboratories, and regional testing centers.

[0003] A detection device is provided inside the fully automatic analyzer, and the detection device detects the sample in the optical detection cell through an optical detection method.

[0004] However, in the existing detection devices, the optical detection components usually have a large structure, which restricts the miniaturization and integration of the whole machine, and is not easy to adjust, and is prone to jamming during adjustment. Summary of the Invention

[0005] The present application provides a sample analyzer and an optical detection device to solve the technical problems in the prior art that the optical detection components usually have a large structure, which restricts the miniaturization and integration of the whole machine, and is not easy to adjust, and is prone to jamming during adjustment.

[0006] To solve the above technical problems, one technical solution adopted by the present application is: to provide an analyzer and an optical detection device, the optical detection device includes an optical substrate sheath flow cell module, a laser module, a forward scattered light receiving module, a lateral scattered light focusing mirror, a lateral spectroscopy module, a lateral scattered light receiving module, and a fluorescence receiving module. The sheath flow cell module is arranged on the optical substrate, the laser module is arranged on the light source substrate and located on the first side of the sheath flow cell module for providing laser to the sheath flow cell module, the forward scattered light receiving module is arranged on the side of the sheath flow cell module away from the laser module, the lateral scattered light focusing mirror is arranged on the second side of the sheath flow cell module, the lateral spectroscopy module is arranged on the side of the lateral scattered light focusing mirror away from the sheath flow cell module, the lateral scattered light receiving module is arranged on the first side of the lateral spectroscopy module, and the fluorescence receiving module is arranged on the second side of the lateral spectroscopy module. The fluorescence receiving module includes an adjusting mechanism and a fluorescence receiver arranged side by side or in a stacked manner.

[0007] To solve the above technical problems, another technical solution adopted by the present application is: to provide a sample analyzer, and the sample analyzer includes the foregoing optical detection device.

[0008] The beneficial effects of the present application are: different from the prior art, the sample analyzer and the optical detection device provided by the present invention have a compact structure, are easy to adjust, and are not prone to jamming. Description of the Drawings

[0009] To more clearly illustrate the technical solutions in the embodiments of the present application, the following will briefly introduce the drawings required for the description of the embodiments. Obviously, the drawings in the following description are only some embodiments of the present application. For those of ordinary skill in the art, without creative efforts, other drawings can be obtained based on these drawings, where:

[0010] Figure 1 is a simplified optical path schematic diagram of the optical detection device provided by the embodiment of the present invention;

[0011] Figure 2 is a three-dimensional structure schematic diagram of the optical detection device provided by the embodiment of the present invention;

[0012] Figure 3 is Figure 2 a partial component schematic diagram of the optical detection device shown in;

[0013] Figure 4 is Figure 3 a partial component schematic diagram of the optical detection device shown in;

[0014] Figure 5 is Figure 4 a partial component schematic diagram of the optical detection device shown in;

[0015] Figure 6 is Figure 3 a partial component schematic diagram of the laser module shown in;

[0016] Figure 7 is Figure 3 a three-dimensional schematic diagram of the laser module shown in;

[0017] Figure 8 is Figure 3 a three-dimensional schematic diagram of the laser module shown in;

[0018] Figure 9 is Figure 3 a side schematic diagram of the laser module shown in;

[0019] Figure 10 is Figure 7 a cross-sectional schematic diagram of the laser module shown in;

[0020] Figure 11 is Figure 7 a partial component schematic diagram of the laser module shown in;

[0021] Figure 12 is Figure 7 a partial component schematic diagram of the laser module shown in;

[0022] Figure 13 isFigure 7 Schematic diagram of partial components of the laser module shown in

[0023] Figure 14 is Figure 7 Schematic diagram of partial components of the laser module shown in

[0024] Figure 15 is Figure 2 Schematic diagram of a fixing method of the laser module shown in

[0025] Figure 16 is Figure 2 Schematic diagram of partial components of the optical detection device shown in

[0026] Figure 17 is Figure 16 Exploded view of the fluorescence receiving module shown in

[0027] Figure 18 is Figure 16 Exploded view of the fluorescence receiving module shown in

[0028] Figure 19 is Figure 2 Partial sectional view of the optical detection device shown in

[0029] Figure 20 is Figure 2 Schematic diagram of partial components of the optical detection device shown in

[0030] Figure 21 is Figure 20 Exploded schematic diagram of the lateral scattered light focusing mirror adjustment module shown in

[0031] Figure 22 is Figure 16 Stereoscopic schematic diagram of the sheath flow cell assembly shown in

[0032] Figure 23 is Figure 20 Cross-sectional view of the sheath flow cell assembly and the lateral scattered light focusing mirror adjustment module shown in Detailed implementation manners

[0033] Next, the technical solutions in the embodiments of the present application will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present application. Obviously, the described embodiments are only a part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present application.

[0034] It should be noted that if there are directional indications (such as up, down, left, right, front, back...) involved in the embodiments of the present invention, then such directional indications are only used to explain the relative positional relationship, movement conditions, etc. between components in a certain specific posture (as shown in the drawings). If this specific posture changes, then the directional indications will also change accordingly.

[0035] In addition, if there are descriptions involving "first", "second", etc. in the embodiments of the present invention, then such descriptions of "first", "second", etc. are only for descriptive purposes and should not be construed as indicating or implying their relative importance or implicitly specifying the quantity of the indicated technical features. Thus, features defined with "first" and "second" may explicitly or implicitly include at least one such feature. In addition, the technical solutions between various embodiments can be combined with each other, but it must be based on the fact that those of ordinary skill in the art can implement them. When the combination of technical solutions results in contradictions or cannot be implemented, it should be considered that such a combination of technical solutions does not exist and is not within the scope of protection required by the present invention.

[0036] As Figure 1 and Figure 2 shown, the present invention provides an optical detection device, which includes an optical substrate 100, a first optical adjustment member 111, a second optical adjustment member 112, a sheath flow cell module 200, a lateral scattered light focusing mirror 250, a laser module (or front light module) 300, a light source substrate 310, a forward scattered light receiving module 400, a lateral light splitting module 500, a lateral scattered light receiving module 600, and a fluorescence receiving module 700.

[0037] In the present invention, the extension direction of the optical axis of the laser module 300 (as shown by the dotted line in reference Figure 10 is defined as the A direction, the direction perpendicular to the A direction in the horizontal plane is defined as the B direction, and the direction perpendicular to the A direction in the vertical plane is defined as the C direction, which can be equivalent to the X / Y / Z directions of a spatial rectangular coordinate system. Of course, these three directions can also be non-perpendicular.

[0038] The light source substrate 310 is slidably adjusted in the B direction and disposed on the optical substrate 100. The sheath flow cell module 200 is disposed on the optical substrate 100. The laser module 300 is disposed on the light source substrate 310 and located on the first side of the sheath flow cell module 200. The laser module 300 includes components such as a laser 340, a collimating lens 341, a forward light focusing lens 342, and a cylindrical lens 343, and is used to provide laser light to the sheath flow cell module 200. The forward scattered light receiving module 400 is disposed on the side of the sheath flow cell module 200 away from the laser module 300. The three components of the forward scattered light receiving module 400, the sheath flow cell module 200, and the laser module 300 are generally arranged in the first linear direction. The forward scattered light receiving module 400 includes a forward scattered light receiving plate 410, a forward scattered light receiving diaphragm 420, and at least one forward scatter adjusting member 430 to adjust in the A direction, B direction, or C direction to improve the light receiving accuracy and enhance the detection accuracy. The forward scatter adjusting member is preferably adjusted in the B direction. Of course, two-dimensional adjustment can also be performed, such as adjusting in the A direction, C direction, or simultaneously in the A and C directions. The forward scattered light receiving module 400 is used to receive the forward laser light after passing through the sheath flow cell module 200. The lateral scattered light focusing lens 250 is disposed on the second side of the sheath flow cell module 200. The second side and the first side can be perpendicular to each other. The lateral scattered light focusing lens 250 is used to receive the lateral laser light after passing through the sheath flow cell module 200. The lateral beam splitting module 500 is disposed on the side of the lateral scattered light focusing lens 250 away from the sheath flow cell module 200. The three components of the lateral beam splitting module 500, the lateral scattered light focusing lens 250, and the sheath flow cell module 200 are generally arranged in the second linear direction. The second linear direction and the aforementioned first linear direction can be perpendicular to each other. The lateral beam splitting module 500 includes a dichroic mirror 510 and a filter 520. The lateral beam splitting module 500 has the functions of beam splitting and filtering. The lateral beam splitting module 500 is used to receive the lateral laser light passing through the lateral scattered light focusing lens 250. The lateral scattered light receiving module 600 is disposed on the first side of the lateral beam splitting module 500. The lateral scattered light receiving module 600 includes a lateral receiving plate 610, a lateral scattered light receiving diaphragm 620, and at least one lateral scatter adjusting member (not shown in the figure) to improve the light receiving accuracy in the A direction, B direction, or C direction and enhance the detection accuracy. The lateral scatter adjusting member is preferably adjusted in the B direction. Of course, two-dimensional adjustment can also be performed, such as adjusting in the A direction, C direction, or simultaneously in the A and C directions. The lateral scattered light receiving module 600 is used to receive the laser light reflected by the lateral beam splitting module 500. The fluorescence receiving module 700 is disposed on the second side of the lateral beam splitting module 500. The fluorescence receiving module 700 includes a fluorescence receiving plate 740 and a fluorescence receiving diaphragm 741. The fluorescence receiving module 700 is used to receive the laser light transmitted by the lateral beam splitting module 500. The fluorescence receiving module 700 includes an adjusting mechanism 752 and a fluorescence receiver 742 arranged side by side or in a stacked manner, such as Figure 2As shown, when the adjustment mechanism 752 and the fluorescence receiver 742 are arranged side by side, the fluorescence receiving module 700 is integrally in the shape of a vertically placed long strip. The adjustment mechanism 752 extends to the side where the laser module 300 is located, making full use of the limited space to make the overall structure of the product compact. If the adjustment mechanism 752 and the fluorescence receiver 742 are arranged in a stacked manner, that is, the adjustment mechanism 752 is arranged on the side of the fluorescence receiver 742 away from the lateral beam splitting module 500, the overall length of the fluorescence receiving module 700 will become shorter, but the thickness will increase.

[0039] Among them, the point light source emitted by the laser 340 passes through the collimating lens 341, the front light focusing lens 342, and the cylindrical lens 343 in sequence, and then an elliptical (major axis about 100 - 200um, minor axis about 10 - 30um) light spot required to reach the sheath flow cell module 200 can be formed to form the light source / light beam for flow cytometry; the light irradiates the particles to be measured (such as blood cells) in the sheath flow cell 201 of the sheath flow cell module 200, generating scattered light in all directions / angles, and the excitation fluorescence generated by irradiating the particles after fluorescence staining; the forward scattered light receiving diaphragm 420 is used to selectively receive scattered light signals within a certain angle range, generally a small angle range, such as 1 - 9°, and this signal characterizes the size information of the particle volume; the lateral scattered light at a certain angle with the light beam, generally 90°, because collecting lateral scattered light requires collecting scattered light in a large angle range, generally the large angle is centered on 90° with the laser 340 and within the range of ±30°, so after being collected and focused by the lateral scattered light focusing lens 250, it first reaches the dichroic mirror 510, which has the functions of reflecting and transmitting wavelengths within a certain interval. It reflects the lateral scattered light that needs to be collected (reflecting the complexity of the cell membrane, cytoplasm, nuclear membrane and other contents and the size of the cell nucleus) to the lateral scattered light receiving module 600, and at the same time selectively transmits the excited fluorescence and reaches the fluorescence receiving module 700.

[0040] As Figures 1 to 16 As shown, the laser module 300 includes a light source substrate 310, a light source base 320, a laser fixing plate 330, a laser 340, a locking plate 350, a locking plate fixing member 351, a first light source adjusting member 331, a second light source adjusting member 332, a laser pressing plate 344, a laser pressing plate locking member 345, a laser fixing plate locking member 333, an elastic pushing member 334, and a translation matching portion 336.

[0041] The light source substrate 310 is a machined part with good flatness. The light source base 320 is provided with a through assembly cavity 322, and the assembly cavity 322 can be in the shape of a stepped cavity (including a circular cavity 340 for assembling the laser and a rectangular cavity for assembling the laser fixing plate 330) to facilitate the limit assembly of internal components (such as the laser fixing plate 330 and the collimating lens 341). The light source base 320 is also provided with an avoidance groove 353 at the end angle matching the laser pressing plate 344 in the assembly cavity 322 to facilitate the adjustment of the laser pressing plate 344.

[0042] The light source base 320 is slidably adjustable in the A direction and is arranged on the light source substrate 310. The laser fixing plate 330 is adjustably embedded in the assembly cavity 322 in the A direction, B direction, and C direction. The laser 340 is embedded in the laser fixing plate 330, and the laser 340 is used to emit laser light in the A direction. In order to make the optical axis of the laser 340 in an ideal state (such as coaxial with the axis of the assembly cavity 322), the present invention is configured such that the laser fixing plate 330 can be adjusted in three directions: the A direction, B direction, and C direction.

[0043] The laser 340 can be pressed into the laser fixing plate 330 by the laser pressing plate 344 and locked by the laser pressing plate locking member 345. The laser pressing plate locking member 345 can be a screw, a snap member, a bonding member, etc. The laser fixing plate 330 is provided with a stepped cavity. The laser pressing plate 344 includes a sleeve portion and a flange portion. The sleeve portion limits and presses the laser 340 in the stepped cavity of the laser fixing plate 330, and the laser pressing plate locking member 345 locks the flange portion on the laser fixing plate 330 to fix the laser 340.

[0044] The locking plate 350 presses the laser fixing plate 330 into the light source base 320 through the locking plate fixing member 351. The locking plate fixing member 351 can be a screw, a snap member, a bonding member, etc. The laser fixing plate locking member 333 passes through the locking plate 350 to adjust and lock the laser fixing plate 330. The laser fixing plate locking member 333 can be a screw, etc. The number of the laser fixing plate locking members 333 can be 1, 2, or more. When the number of the laser fixing plate locking members 333 is 2, they can be arranged diagonally. By rotating any one of the two laser fixing plate locking members 333 clockwise or counterclockwise, the pose of the laser fixing plate 330 can be adjusted. For example, the pose of the laser fixing plate 330 can be adjusted to a vertical state.

[0045] The first light source adjusting member 331 passes through the adjusting hole 329 (see Figure 6)It extends into the light source base 320 to adjust the laser fixing plate 330 in the B direction. The second light source adjusting member 332 extends into the light source base 320 through the adjusting hole 329 to adjust the laser fixing plate 330 in the C direction. The first light source adjusting member 331 and the second light source adjusting member 332 can be screws, screw pairs, etc. Since the assembly precision requirements of the laser fixing plate 330 are very high, in some embodiments, the first light source adjusting member 331 and the second light source adjusting member 332 can be removed after adjustment to avoid incorrect adjustment by non-professionals. Of course, the first light source adjusting member 331 and the second light source adjusting member 332 can also be left on the light source base 320 for professional debuggers to adjust.

[0046] As Figure 10 shown, the light source base 320 is also provided with a convex ring portion 323 corresponding to the assembly cavity. The convex ring portion 323 can be positioned and sleeved as Figure 8 and Figure 9 shown in the lens barrel portion 324. The lens barrel portion 324 can be used to arrange the aforementioned front light focusing lens 342, cylindrical lens 343 and other optical lenses. The lens barrel portion 324 and the light source base 320 can be integrally formed or assembled in a split shape. When integrally formed, the precision is relatively high, and when assembled in a split shape, it is convenient for manufacturing.

[0047] The first optical adjusting member 111 can be installed through the light source substrate 310 or other additional plates and connected to the light source base 320. The light source base 320 has corresponding connection holes 113 for adjusting the sliding of the light source base 320 relative to the light source substrate 310 in the A direction. The second optical adjusting member 112 is installed through the optical substrate 110 or other additional plates and connected to the light source substrate 310 for adjusting the sliding of the light source substrate 310 relative to the optical substrate 100 in the B direction. The first optical adjusting member 111 and the second optical adjusting member 112 can be adjusting mechanisms such as screw pairs, slider assemblies, motor assemblies, gear assemblies, etc., preferably screw pairs.

[0048] The adjustment requirements can be better met through the four adjusting members and the laser fixing plate locking member 333. Among them, the first light source adjusting member 331 and the second light source adjusting member 332 can be used for up, down, left and right adjustment. The first optical adjusting member 111 and the second optical adjusting member 112 can be adjusted relatively in the front, back, left and right directions. The laser fixing plate locking member 333 can adjust the overall inclination of the plate surface pose of the laser fixing plate 330.

[0049] The elastic pushing member 334 is embedded through the embedding hole 328 (see Figure 6)It is embedded and assembled on the light source base 320 and elastically abuts against the surface of the laser fixing plate 330 away from the first light source adjusting member 331 and the second light source adjusting member 332. The elastic pushing member 334 can be an elastic ball plunger, a spring or elastic silica gel. The translation matching portion 336 is embedded and assembled in the light source base 320 and abuts against the surface of the laser fixing plate 330 away from the locking plate 350. When the first light source adjusting member 331 and the second light source adjusting member 332 perform screw adjustment, an adjusting mechanism with mutual pushing force is formed with the elastic pushing member 334 to ensure better adjustability. When the laser fixing plate locking member 333 performs screw adjustment, an adjusting mechanism with mutual pushing force is formed with the translation matching portion 336 to ensure better adjustability. Of course, the elastic pushing member 334 only plays a passive matching role and will not cause the position change of the laser fixing plate locking member 333 due to the removal of the first light source adjusting member 331 and the second light source adjusting member 332.

[0050] The light source base 320 or the light source substrate 310 is provided with a protruding sliding matching portion 321 (see Figure 6 ) to reduce the friction force during the sliding adjustment in the A direction. The light source substrate 310 or the optical substrate 100 is provided with a protruding sliding matching portion 311 (see Figure 5 ) to reduce the friction force during the sliding adjustment in the B direction. The sliding matching portions (311, 321) can be protruding portions of an integral structure on the optical substrate 100, or the light source substrate 310 or the light source base 320. Or the sliding matching portions (311, 321) can be elastic ball plungers or balls embedded in the optical substrate 100, the light source substrate 310 or the light source base 320 (see Figure 8 、 Figure 9 ). By reducing the contact area, the friction force is reduced, making the sliding adjustment smoother.

[0051] Such as Figures 16 - 18As shown in the figure, the fluorescence receiving module 700 includes a fixed base 730, a first moving substrate 710, a second moving substrate 720, a fluorescence receiving plate 740, a fluorescence receiver 742, a first fluorescence adjusting member 701, a second fluorescence adjusting member 702, a first locking member 716, and a second locking member 726. The first locking member 716 and the second locking member 726 can be screws. The fluorescence receiving module 700 includes an adjusting mechanism 752 and a fluorescence receiver 742 arranged side by side or in a stacked manner. As shown in Figure 2, when the adjusting mechanism 752 and the fluorescence receiver 742 are arranged side by side, the fluorescence receiving module 700 is integrally in the shape of a vertically placed long strip, and the adjusting mechanism 752 extends to the side where the laser module 300 is located, making full use of the limited space to make the overall structure of the product compact. If the adjusting mechanism 752 and the fluorescence receiver 742 are arranged in a stacked manner, that is, the adjusting mechanism 752 is arranged on the side of the fluorescence receiver 742 away from the lateral splitting module 500, the overall length of the fluorescence receiving module 700 will become shorter, but the thickness will increase.

[0052] The first moving substrate 710 is slidably adjusted on the fixed base 730 in the C direction, the second moving substrate 720 is slidably adjusted on the first moving substrate 710 in the A direction, and the fluorescence receiver 742 is fixed on the second moving substrate 720. Of course, in some embodiments, the second moving substrate 720 may not be provided, and the fluorescence receiving plate 740 can be slidably adjusted on the first moving substrate 710.

[0053] The fixed base 730 may include a main body plate 731 and a folding plate 732 provided on the side of the main body plate 731. The folding plate 732 is used to provide the first fluorescence adjusting member 701 to adjust the first moving substrate 710 in the C direction. The first fluorescence adjusting member 701 can be an adjusting mechanism such as a screw pair, a slider assembly, a motor assembly, a gear assembly, etc.

[0054] The main body plate 731 is provided with a first guiding post 734, the first moving substrate 710 is provided with a C-direction guiding groove 714 matching the first guiding post 734, the main body plate 731 is provided with a first locking hole 735, the first moving substrate 710 is provided with a first locking groove 715 matching the first locking hole 735, the first locking member 716 passes through the first locking groove 715 and cooperates with the first locking hole 735, the first moving substrate 710 is provided with a second guiding post 714, and the second moving substrate 720 is provided with an A-direction guiding groove 724 matching the second guiding post 714.

[0055] The first moving substrate 710 is provided with a second locking hole 715. The second moving substrate 720 is provided with a second locking groove 725 that matches the second locking hole 715. The second locking member 726 passes through the second locking groove 725 and cooperates with the second locking hole 715. The first moving substrate 710 includes a first plate body 711, a second plate body 712 and a third plate body 713 that are bent in opposite directions from the edge of the first plate body 711. The first plate body 711 is attached to the main body plate 731. The second plate body 712 is parallel to the folding plate 732. The third plate body 713 is used to arrange the second fluorescence adjusting member 702 to adjust the second moving substrate 720 in the A direction.

[0056] The fluorescence receiving plate 740 is fixed to the second moving substrate 720. The fluorescence receiver 742 is fixed on the fluorescence receiving plate 740. The second moving substrate 720 is provided with a through groove 721 that is aligned with the fluorescence receiver 742. The fluorescence receiver 742 can be embedded and assembled in the through groove 721. The fluorescence receiving module 700 further includes a fluorescence diaphragm 741. The fluorescence diaphragm 741 is fixed to the second moving substrate 720 and covers the through groove 721. The fluorescence diaphragm 741 is provided with a light hole 743 that is aligned with the fluorescence receiver 742.

[0057] As Figure 19 shown, the optical detection device further includes an optical bottom case 91, an optical cover that cooperates with the optical bottom case 91, a lower shock absorber 93, an upper shock absorber 94 and a first connecting member 95. The optical bottom case 91 is provided with a second connecting member 96. The second connecting member 96 can be an integrally formed or assembled snap post or threaded post on the optical bottom case 91. The second connecting member 96 has a snap position or an internal thread. The lower shock absorber 93 is sleeved on the outer periphery of the second connecting member 96. The optical substrate 100 is provided with a lower stepped hole 104 and an upper stepped hole 105. The optical substrate 100 is sleeved on the second connecting member 96 and is pressed on the lower shock absorber 93 through the lower stepped hole 104. The outer peripheral wall of the upper shock absorber 94 is stepped. The upper shock absorber 94 is in stepped cooperation with the upper stepped hole 105 and is spaced between the second connecting member 96 and the optical substrate 100. The bottom surface of the upper shock absorber 94 and the top end of the lower shock absorber 93 can be spaced apart. The top end of the upper shock absorber 94 is higher than the top end of the second connecting member 96. The first connecting member 95 is snap-connected or screwed to the second connecting member 96 and is pressed on the top surface of the upper shock absorber 94 to achieve a better anti-vibration support effect. The upper shock absorber 94 or the lower shock absorber 93 can be an element with better elastic properties such as a silica gel cylinder or a spring.

[0058] The optical detection device provided by the present invention has a compact structure, is convenient to adjust, and is not prone to jamming. Its laser module 300 can be adjusted in multiple dimensions through four adjusting members and the laser fixing plate locking member 333, and the operation is flexible and convenient. In addition, by setting the sliding fit portion 321, the friction during adjustment can be reduced, and smooth adjustment can be achieved to avoid jamming. The present invention also provides a sample analyzer, which includes the aforementioned optical detection device. The sample analyzer can specifically be a blood cell analyzer, a flow cytometer, a coagulation analyzer, an immunoassay analyzer, etc.

[0059] As Figures 1 to 14 shown, the present invention also provides a laser module 300, which includes an optical substrate 100, a first optical adjusting member 111, a second optical adjusting member 112, a light source substrate 310, a light source base 320, a laser fixing plate 330, a laser 340, a locking plate 350, a first light source adjusting member 331, a second light source adjusting member 332, a laser fixing plate locking member 333, an elastic pushing member 334, a translation fit portion 336, a collimating lens 341, a first oblique pressing member 360, and a second oblique pressing member 370.

[0060] Among them, the light source substrate 310 is a machined part with good flatness. The light source base 320 is slidably adjusted in the A direction and is arranged on the light source substrate 310. The light source substrate 320 is slidably adjusted in the B direction and is arranged on the optical substrate 310. The first optical adjusting member 111 is installed through the light source substrate 310 or other additional plates and is connected to the light source base 320, and is used to adjust the sliding of the light source base 320 relative to the light source substrate 310 in the A direction. The light source base 320 has a connection hole 113 (see Figure 7 ) that matches the first optical adjusting member 111. The second optical adjusting member 112 is installed through the optical substrate 110 or other additional plates and is connected to the light source substrate 310. The light source substrate 310 has a connection hole 114 (see Figure 5 ) corresponding to the second optical adjusting member 112, and is used to adjust the sliding of the light source substrate 310 relative to the optical substrate 100 in the B direction. The first optical adjusting member 111 and the second optical adjusting member 112 can be adjusting mechanisms such as a screw pair, a slider assembly, a motor assembly, a gear assembly, etc.

[0061] The light source base 320 is provided with a through assembly cavity 322, which can be in the shape of a stepped cavity (including a circular cavity 340 for assembling the laser and a rectangular cavity for assembling the laser fixing plate 330) to facilitate the limit assembly of internal components (such as the laser fixing plate 330 and the collimating lens 341).

[0062] The laser fixing plate 330 is adjustably embedded in the assembly cavity 322 in the A direction, B direction, and C direction. The laser 340 is embedded in the laser fixing plate 330 and is used to emit laser light in the A direction. In order to make the optical axis of the laser 340 in an ideal state (for example, coaxial with the axis of the assembly cavity 322), the present invention is configured such that the laser fixing plate 330 can be adjusted in three directions: the A direction, B direction, and C direction.

[0063] The laser collimating lens 341 is embedded in the assembly cavity 322 and is located in front of the laser 340. The locking plate 350 cooperates with the light source base 320 to press the laser fixing plate 330 into the light source base 320. The laser fixing plate locking member 333 passes through the locking plate 350 to adjust the laser fixing plate 330 and lock the pose of the laser fixing plate 330 after adjustment. The laser fixing plate locking member 333 can be a screw or the like, and the number of laser fixing plate locking members 333 can be 1, 2, or more. When the number of laser fixing plate locking members 333 is 2, they can be arranged diagonally. By rotating either of the two laser fixing plate locking members 333 clockwise or counterclockwise, the pose of the laser fixing plate 330 can be adjusted. For example, the pose of the laser fixing plate 330 can be adjusted to a vertical state.

[0064] The first light source adjusting member 331 extends into the light source base 320 through the adjusting hole 329 (see Figure 6 ) to adjust the laser fixing plate 330 in the B direction, and the second light source adjusting member 332 extends into the light source base 320 through the adjusting hole 329 (see Figure 6 ) to adjust the laser fixing plate 330 in the C direction. The first light source adjusting member 331 and the second light source adjusting member 332 can be screws, thread pairs, etc. Since the assembly accuracy requirements for the laser fixing plate 330 are very high, in some embodiments, the first light source adjusting member 331 and the second light source adjusting member 332 can be removed after adjustment to prevent non-professionals from making incorrect adjustments. Of course, the first light source adjusting member 331 and the second light source adjusting member 332 can also be left on the light source base 320 for professional debuggers to adjust.

[0065] As Figure 10 shown, the light source base 320 is also provided with a convex ring portion 323 corresponding to the assembly cavity. The convex ring portion 323 can be positioned and sleeved with the lens barrel portion 324 as shown in Figure 8 and Figure 9 shown. The lens barrel portion 324 can be used to set optical lenses such as the aforementioned front light focusing lens 342 and cylindrical lens 343.

[0066] The elastic pushing member 334 is embedded and assembled on the light source base 320 and elastically abuts against the surface of the laser fixing plate 330 away from the first light source adjusting member 331 and the second light source adjusting member 332. The elastic pushing member 334 can be an elastic ball plunger, a spring or elastic silica gel.

[0067] The translation fitting portion 336 is embedded and assembled in the light source base 320. The translation fitting portion 336 abuts against the surface of the laser fixing plate 330 away from the locking plate 350. The translation fitting portion 336 can be an elastic ball plunger, a ball or a protruding portion of an integral structure to reduce the frictional force during sliding adjustment. When the first light source adjusting member 331 and the second light source adjusting member 332 perform screw adjustment, they form a mutual pushing force with the elastic pushing member 334 to ensure better adjustability. When the laser fixing plate locking member 333 performs screw adjustment, it forms a mutual pushing force with the translation fitting portion 336 to ensure better adjustability. Of course, the elastic pushing member 334 only plays a passive matching role and will not cause the position change of the laser fixing plate locking member 333 due to the removal of the first light source adjusting member 331 and the second light source adjusting member 332.

[0068] The first oblique pressing member 360 is fixed to the light source substrate 310. The light source base 320 is provided with a first pressing portion 361 matching the first oblique pressing member 360. The first oblique pressing member 360 is an elastic pressing sheet, a pressing block or an elastic ball plunger. The first oblique pressing member 360 can be fixed through the light source substrate 310, for example Figure 3 as shown. When the first oblique pressing member 360 is an elastic ball plunger, refer to Figure 15 as shown. This first oblique pressing member 360 not only plays a role in obliquely and elastically pressing the light source base 320, but also has a relatively small frictional resistance due to the spherical contact at the pressing portion, and the adjustment is relatively smooth. The bottom surface and / or side surface of the light source substrate 310 is provided with an elastic ball plunger, a ball or a sliding fitting portion 321 provided in a protruding manner to reduce the frictional force during sliding adjustment.

[0069] The second oblique pressing member 370 is fixed to the optical substrate 100. The light source substrate 310 is provided with a second pressing portion 371 matching the second oblique pressing member 370. The second oblique pressing member 370 is an elastic pressing sheet or an elastic ball plunger. The bottom surface and / or side surface of the light source substrate 310 is provided with an elastic ball plunger, a ball or a sliding fitting portion provided in a protruding manner to reduce the frictional force during sliding adjustment.

[0070] The laser module 300 may further include a heating element (not shown in the figure), a temperature sensor 382, and a temperature switch (not shown in the figure). The light source base 320 is provided with an assembly groove 381 or assembly holes (383, 384). The heating element, the temperature sensor 382, and the temperature switch are installed in the assembly groove 381 or the assembly holes (383, 384). When the temperature sensor 382 is installed in the assembly groove 381, it can be covered by a cover plate 385. The heating element can ensure that the collimating lens 341, the front light focusing lens 342, and the cylindrical lens 343 work at a constant temperature, ensuring the consistency of light output. The outer periphery of the light source base 320 can be further wrapped with heat insulation cotton to improve the heat insulation effect.

[0071] The laser module 300 provided by the present invention has a compact structure, is easy to adjust, and is not prone to jamming. The laser module 300 can be adjusted in multiple dimensions through four adjusting parts and the laser fixing plate locking part 333, and the operation is flexible and convenient. In addition, by setting the sliding fit part 321, the friction during adjustment can be reduced, and smooth adjustment can be achieved to avoid jamming. The present invention also provides a sample analyzer, which includes the aforementioned laser module 300. The sample analyzer can specifically be a blood cell analyzer, a flow cytometer, a coagulation analyzer, an immunoassay analyzer, etc.

[0072] As Figures 1 to 16 shown, the present invention also provides an optical detection device, which includes an optical substrate 100, a light source substrate 310, a laser module 300, a first inclined pressing part 360, and a second inclined pressing part 370.

[0073] As Figure 4 、 Figure 5 shown, the light source substrate 310 is slidably adjusted and arranged on the optical substrate 100 in the B direction. Among them, the light source substrate 310 or the optical substrate 100 is provided with a protruding sliding fit part 311 to reduce the friction during the sliding adjustment. The light source substrate 310 is provided with a guiding adjustment groove 115. After the light source substrate 310 is slidably adjusted in the B direction, the adjustment position can be locked by a screw 116 passing through the guiding adjustment groove 115.

[0074] As Figure 3 、 Figure 6 shown, the laser module 300 is slidably adjusted and arranged on the light source substrate 310 in the A direction. The laser module 300 or the light source substrate 310 is provided with a sliding fit part 321. The laser module 300 is provided with a guiding adjustment groove 354. After the laser module 300 is slidably adjusted in the A direction, the adjustment position can be locked by a screw 355 (see Figure 3 ) passing through the guiding adjustment groove 354.

[0075] The sliding fit portion 311 is a protruding portion of an integral structure on the optical substrate 100 or the light source substrate 310, or the sliding fit portion 311 is an elastic ball plunger or a ball embedded in the optical substrate 100 or the light source substrate 310.

[0076] The light source substrate 310 is provided with a first sliding adjustment area 372, and the laser module 300 is slidably disposed within the first sliding adjustment area 372. The first sliding adjustment area 372 is composed of a first bottom wall 373 and a first guiding side wall 374. The laser module 300 abuts against the first guiding side wall 374. The first optical adjustment member 111 is mounted through the light source substrate 310 and connected to the light source base 320, and is used to adjust the sliding of the light source base 320 relative to the light source substrate 310 in the A direction. The first sliding adjustment area 372 can be an area recessed in the surface of the light source substrate 310, or the light source substrate 310 is provided with ribs to provide the first guiding side wall 374.

[0077] As Figure 3 or Figure 15 shown, the first obliquely pressing member 360 is fixed to the light source substrate 310 and is used to elastically press and buckle the laser module 300 so that one surface of the laser module 300 abuts against the first guiding side wall 374. The first obliquely pressing member 360 is an elastic pressing sheet or an elastic ball plunger, and a first pressing portion 361 for abutting against the first obliquely pressing member 360 is provided on the laser module 300 (see Figure 7 ).

[0078] As Figure 16 shown, the optical substrate 100 is provided with a second sliding adjustment area 101, and the light source substrate 310 is slidably disposed within the second sliding adjustment area 101. The second sliding adjustment area 101 is composed of a second bottom wall 102 and a second guiding side wall 103. The light source substrate 310 abuts against the second guiding side wall 103. The optical detection device further includes a second optical adjustment member 112. The first optical adjustment member 112 is used to adjust the sliding of the light source substrate 310 relative to the optical substrate 100 in the B direction. The second sliding adjustment area 101 can be an area recessed in the surface of the optical substrate 100, or the optical substrate 100 is provided with ribs to provide the second guiding side wall 102.

[0079] The second obliquely pressing member 370 is fixed to the optical substrate 100 or other additional plates and is used to obliquely and elastically press and buckle the light source substrate 310 so that one surface of the light source substrate 310 abuts against the second guiding side wall 102. The second obliquely pressing member 370 is an elastic pressing sheet or an elastic ball plunger, and a second pressing portion 371 for abutting against the second obliquely pressing member 370 is provided on the light source substrate 310.

[0080] The optical detection device provided by the present invention has a compact structure, convenient adjustment, small friction, and is not prone to jamming. The light source substrate 310 is slidably adjusted in the B direction and is arranged on the optical substrate 100. The light source substrate 310 or the optical substrate 100 is provided with a protruding sliding fit portion 311 to reduce friction during sliding adjustment. The present invention also provides a sample analyzer, which includes the aforementioned optical detection device. The sample analyzer can specifically be a blood cell analyzer, a flow cytometer, a coagulation analyzer, an immunoassay analyzer, etc.

[0081] As Figures 16 - 18 shown, the present invention also provides a fluorescence receiving module 700, which includes a fixed seat 730, a first moving substrate 710, a second moving substrate 720, a fluorescence receiving plate 740, a fluorescence receiver 742, a first fluorescence adjusting member 701, a second fluorescence adjusting member 702, a first locking member 716, and a second locking member 726. The fluorescence receiving module 700 includes an adjusting mechanism 752 and a fluorescence receiver 742 arranged side by side or in a stacked manner. As Figure 2 shown, when the adjusting mechanism 752 and the fluorescence receiver 742 are arranged side by side, the fluorescence receiving module 700 is integrally in the shape of a vertically placed long strip, and the adjusting mechanism 752 extends to the side where the laser module 300 is located, making full use of the limited space to make the overall structure of the product compact. If the adjusting mechanism 752 and the fluorescence receiver 742 are arranged in a stacked manner, that is, the adjusting mechanism 752 is arranged on the side of the fluorescence receiver 742 away from the lateral splitting module 500, the overall length of the fluorescence receiving module 700 will become shorter, but the thickness will increase.

[0082] The first moving substrate 710 is slidably adjusted in the C direction and is arranged on the fixed seat 730, and the second moving substrate 720 is slidably adjusted in the A direction and is arranged on the first moving substrate 710; the fluorescence receiver 742 is fixed to the second moving substrate 720. The fixed seat 730 includes a main body plate 731 and a folding plate 732 arranged on the side of the main body plate 731. The folding plate 732 is used to arrange the first fluorescence adjusting member 701 to adjust the first moving substrate 710 in the C direction.

[0083] The main body plate 731 is provided with a first guiding column 734, the first moving substrate 710 is provided with a C-direction guiding groove 714 matching the first guiding column 734, the main body plate 731 is provided with a first locking hole 735, the first moving substrate 710 is provided with a first locking groove 715 matching the first locking hole 735, and the first locking member 716 passes through the first locking groove 715 and cooperates with the first locking hole 735.

[0084] The first moving substrate 710 is provided with second guide posts 714, and the second moving substrate 720 is provided with A-direction guide grooves 724 that match the second guide posts 714. The first moving substrate 710 is provided with second locking holes 715, and the second moving substrate 720 is provided with second locking grooves 725 that match the second locking holes 715. A second locking member 726 passes through the second locking groove 725 and cooperates with the second locking hole 715. The first moving substrate 710 includes a first plate body 711, a second plate body 712 and a third plate body 713 that are bent in opposite directions from the edge of the first plate body 711. The first plate body 711 is attached to the main body plate 731, the second plate body 712 is parallel to the folding plate 732, and the third plate body 713 is used to arrange the second fluorescence adjusting member 702 to adjust the second moving substrate 720 in the A direction.

[0085] The fluorescence receiving plate 740 is fixed to the second moving substrate 720, the fluorescence receiver 742 is fixed on the fluorescence receiving plate 740. The second moving substrate 720 is provided with a through groove 721 that is aligned with the fluorescence receiver 742. The fluorescence receiver 742 can be embedded and assembled in the through groove 721. The fluorescence diaphragm 741 is fixed to the second moving substrate 720 and covers the through groove 721. The fluorescence diaphragm 741 is provided with a light hole 743 that is aligned with the fluorescence receiver 742.

[0086] The fluorescence receiving module 700 provided by the present invention has a compact structure, is convenient to adjust, is not prone to jamming, and the adjusting mechanism 752 extends to the side where the laser module 300 is located, making full use of the limited space to make the overall structure of the product compact. The present invention also provides a sample analyzer, which includes the aforementioned fluorescence receiving module 700. The sample analyzer can specifically be a blood cell analyzer, a flow cytometer, a coagulation analyzer, an immunoassay analyzer, etc.

[0087] As Figures 20 to 23 shown, the present invention also provides a lateral scattered light focusing lens adjusting module, which includes a mounting seat 210, a support plate 220, an adjusting member 230, a linkage block 240, a guide post 248, a locking member 252, a sheath flow cell module locking member 260 and an optical substrate 100.

[0088] The mounting seat 210 is provided with a side wall 211 and a top wall 212. The side wall 211 and the top wall 212 enclose an inner cavity 213. The top wall 212 is provided with an opening 214 that communicates with the inner cavity 213 (see Figure 21 ), and the inner cavity 213 is used to receive the sheath flow cell module 200 for insertion and assembly and extend out of the opening 214 so that the sheath flow cell 201 of the sheath flow cell module 200 is arranged above the top wall 212. The sheath flow cell module 200 can be rotated and adjusted relative to the mounting seat 210 and fixed.

[0089] The linkage block 240 is adjustably arranged on the top wall 212. The linkage block 240 is used to set the lateral scattered light focusing mirror 250 corresponding to the sheath flow cell 201.

[0090] The adjusting member 230 is connected to the linkage block 240 and is used to adjust the position of the linkage block 240 on the mounting base 210, thereby adjusting the distance between the lateral scattered light focusing mirror 250 and the sheath flow cell 201. The adjusting member 230 can be an adjusting mechanism such as a screw, a screw pair, a slider assembly, a motor assembly, a gear assembly, etc.

[0091] Specifically, the linkage block 240 includes a first linkage block 241 and a second linkage block 242 connected to each other. A third linkage block 243 can be connected to the side of the first linkage block 241 away from the second linkage block 242. The first linkage block 241 can be provided with a connection hole 247 for connecting to the adjusting member 230, or the third linkage block 243 is provided with a connection hole 247. The first linkage block 241 is slidably arranged on the top wall 212, and the second linkage block 242 is used to set the lateral scattered light focusing mirror 250.

[0092] The second linkage block 242 has an extension part 244 offset from the first linkage block 241, and the lateral scattered light focusing mirror 250 is arranged on the extension part 244. In one embodiment, the second linkage block 242 can be L-shaped, and the lateral scattered light focusing mirror 250 is arranged at the end of the L-shaped second linkage block 242.

[0093] The first linkage block 241 is provided with a guiding groove 246 corresponding to the guiding column 248, and the top wall 212 is provided with an assembly hole 249 corresponding to the guiding column 248 for assembling the guiding column 248. The first linkage block 241 is provided with a locking groove 245 corresponding to the locking member, and the top wall 212 is provided with a locking hole 253 corresponding to the locking member 252. The top wall 212 is provided with a through hole 261 corresponding to the sheath flow cell module locking member 260. The sheath flow cell module locking member 260 is used to pass through the through hole 261 to connect with the sheath flow cell module 200. Correspondingly, the sheath flow cell module 200 is provided with a connection flange 210, and the connection flange 210 is provided with connection screw holes 211.

[0094] The support plate 220 is arranged on the side of the mounting base 210, and the support plate 220 is used to support the adjusting member 230. The mounting base 210 is fixed on the optical bottom plate 100, and the sheath flow cell module 200 penetrates through the optical substrate 100.

[0095] The lateral scattered light focusing mirror adjustment module provided by the present invention can avoid the situation that when the conventional sheath flow cell module 200 is installed from top to bottom, the hand will touch the surface of the sheath flow cell 201, causing contamination of the optical surface.

[0096] The present invention also provides a sample analyzer, which includes the aforementioned lateral scattered light focusing mirror adjustment module.

[0097] In the above embodiments, during adjustment, the sheath flow base is used as a reference to adjust the beam and / or focus of the light source or the receiving module, ensuring that the beam can be aligned with the center of the sample particle flow in the sheath flow cell 201 and obtaining an appropriate spot size. Therefore, through multi-module multi-dimensional adjustment, the present invention not only fully ensures the compactness and utilization rate of space, but also improves the accuracy of optical detection, which is of great significance for the detection of the sample analyzer. The adjustment effects of each module are described in detail as follows:

[0098] The laser module has four-dimensional adjustment, that is, through the coordinated action of the optical substrate 100, the light source substrate 310, the first optical adjustment member 111, and the second optical adjustment member 112, to achieve the adjustment of the spot size in the A direction and the adjustment of the beam position in the B and C directions. The ultimate goal is to ensure that the beam is aligned with the center of the sample particle flow in the sheath flow cell 201.

[0099] The sheath flow cell module 200 has two-dimensional adjustment. One is rotational adjustment, and the other is to adjust the distance from the lateral scattered light focusing mirror 250, which is also to calibrate the position and focus of the beam. In addition, due to the use of the fluorescence receiving module 700, the sheath flow cell module 200 only performs adjustment in the B direction, and the A direction is fixed. This is to avoid the influence of the movement in the A direction on the optical detection of the forward scattered light receiving module 400, and to save the structure of the detection module to make the space more compact.

[0100] The forward scattered light receiving module 400 adopts one-dimensional adjustment, that is, adjustment in the B direction, mainly to align the beam with the light hole and improve the accuracy of the optical path detection. Of course, two-dimensional adjustment can also be performed, and the space can be made more compact by arranging the adjustment mechanism and the receiving part side by side.

[0101] The fluorescence receiving module 700 adopts two-dimensional adjustment, and the adjustment in both the A direction and the B direction is to align the beam with the diaphragm.

[0102] The lateral scattered light receiving module 600 adopts one-dimensional adjustment, and two-dimensional adjustment can also be performed, but one-dimensional adjustment is preferred. One-dimensional adjustment is also to align the receiving light hole with the beam.

[0103] The above is only the implementation mode of the present invention, and does not limit the patent scope of the present invention accordingly. Any equivalent structure or equivalent process transformation made by using the specification and drawings of the present invention, or directly or indirectly applied to other related technical fields, shall be similarly included in the patent protection scope of the present invention.

Claims

1. An optical detection device, characterized in that, it includes: an optical substrate; a sheath flow cell module disposed on the optical substrate; a laser module disposed on the optical substrate and located on the first side of the sheath flow cell module for providing laser to the sheath flow cell module; a forward scattered light receiving module disposed on the side of the sheath flow cell module away from the laser module, and the forward scattered light receiving module includes a forward scattered light receiving plate and a forward scattered light receiving diaphragm; a lateral scattered light focusing mirror disposed on the second side of the sheath flow cell module; a lateral light splitting module disposed on the side of the lateral scattered light focusing mirror away from the sheath flow cell module; a lateral scattered light receiving module disposed on the first side of the lateral light splitting module; a fluorescence receiving module disposed on the second side of the lateral light splitting module, and the fluorescence receiving module includes an adjusting mechanism and a fluorescence receiver arranged side by side or in a stacked manner; wherein, the adjusting mechanism of the fluorescence receiving module includes: a fixed seat; a first moving substrate slidably adjustable in the C direction on the fixed seat; the fluorescence receiver slidably adjustable relative to the first moving substrate in the A direction; the adjusting mechanism of the fluorescence receiving module further includes a second moving substrate slidably adjustable in the A direction on the first moving substrate, and the fluorescence receiver is fixed to the second moving substrate; the fixed seat includes a main body plate and a folding plate disposed on the side of the main body plate, and the folding plate is used to set a first fluorescence adjusting member to adjust the first moving substrate in the C direction; and / or a first guiding post is provided on the main body plate, and a C-direction guiding groove matching the first guiding post is provided on the first moving substrate; and / or a first locking hole is provided on the main body plate, a first locking groove matching the first locking hole is provided on the first moving substrate, and the fluorescence receiving module further includes a first locking member, and the first locking member passes through the first locking groove and cooperates with the first locking hole; and / or a second guiding post is provided on the first moving substrate, an A-direction guiding groove matching the second guiding post is provided on the second moving substrate, a second locking hole is provided on the first moving substrate, a second locking groove matching the second locking hole is provided on the second moving substrate, and the fluorescence receiving module further includes a second locking member, and the second locking member passes through the second locking groove and cooperates with the second locking hole; and / or the first moving substrate includes a first plate body, a second plate body bent from the edge of the first plate body, and a third plate body, the first plate body is attached to the main body plate, the second plate body is parallel to the folding plate, and the third plate body is used to set a second fluorescence adjusting member to adjust the second moving substrate in the A direction; and / or The fluorescence receiving module further includes a fluorescence receiving plate, the fluorescence receiving plate is fixed to the second moving substrate, the fluorescence receiver is fixed on the fluorescence receiving plate, the second moving substrate is provided with a through groove aligned with the fluorescence receiver, and / or the fluorescence receiving module further includes a fluorescence diaphragm, the fluorescence diaphragm is fixed on the second moving substrate and covers the through groove, and the fluorescence diaphragm is provided with a light hole aligned with the fluorescence receiver; and / or The optical detection device further includes an optical bottom case, a lower shock absorber, an upper shock absorber, and a second connecting member. The optical bottom case is provided with a first connecting member. The lower shock absorber is sleeved on the outer periphery of the first connecting member. The optical substrate is provided with a lower stepped hole and an upper stepped hole. The optical substrate is sleeved on the first connecting member and is pressed on the lower shock absorber through the lower stepped hole. The outer peripheral wall of the upper shock absorber is stepped. The upper shock absorber is in stepped cooperation with the upper stepped hole and is spaced between the first connecting member and the optical substrate. The bottom surface of the upper shock absorber is spaced from the top end of the lower shock absorber. The top end of the upper shock absorber is higher than the top end of the first connecting member. The second connecting member is spirally connected to the first connecting member and presses on the top surface of the upper shock absorber.

2. The optical detection device according to claim 1, characterized in that: The forward scattered light receiving module has at least one forward scatter adjusting member; and / or The lateral scattered light receiving module has at least one lateral scatter adjusting member; and / or The laser module further includes a light source substrate, the light source substrate is slidably adjustable in the B direction on the optical substrate, and the laser module is provided on the optical substrate through the light source substrate.

3. The optical detection device according to claim 2, characterized in that, The laser module includes: A light source base provided with an assembly cavity and slidably adjustable in the A direction on the light source substrate; A laser fixing plate adjustably embedded in the assembly cavity in the A direction, B direction, and C direction; A laser embedded in the laser fixing plate for emitting laser light in the A direction; A laser locking member for adjusting and locking the laser fixing plate.

4. The optical detection device according to claim 3, characterized in that, The optical detection device includes: A locking plate cooperating with the light source base to press the laser fixing plate into the light source base, and the laser locking member penetrates through the locking plate to adjust and lock the laser fixing plate; and / or A first light source adjusting member extending into the light source base to adjust the laser fixing plate in the B direction; and / or A second light source adjusting member extending into the light source base to adjust the laser fixing plate in the C direction; and / or A first optical adjusting member connected to the light source base for adjusting the sliding of the light source base relative to the light source substrate in the A direction; and / or A second optical adjusting member connected to the light source substrate for adjusting the sliding of the light source substrate relative to the optical substrate in the B direction.

5. The optical detection device according to claim 3, characterized in that: The optical detection device includes a first light source adjuster and a second light source adjuster. The laser module further includes an elastic pushing member which elastically abuts against the surface of the laser fixing plate away from the first light source adjuster and the second light source adjuster; and / or The optical detection device includes a locking plate. The laser module further includes a translation mating part which is embedded in the light source base and abuts against the surface of the laser fixing plate away from the locking plate; and / or The light source base or the light source substrate is provided with a protruding sliding mating part to reduce the friction force during the sliding adjustment in the A direction; and / or The light source base or the light source substrate is provided with a protruding sliding mating part to reduce the friction force during the sliding adjustment in the A direction. The sliding mating part is a protruding part of an integral structure on the optical substrate, the light source substrate or the light source base, or the sliding mating part is an elastic ball plunger or a ball embedded in the optical substrate, the light source substrate or the light source base; and / or The light source substrate or the optical substrate is provided with a protruding sliding mating part to reduce the friction force during the sliding adjustment in the B direction; and / or The light source substrate or the optical substrate is provided with a protruding sliding mating part to reduce the friction force during the sliding adjustment in the B direction. The sliding mating part is a protruding part of an integral structure on the optical substrate, the light source substrate or the light source base, or the sliding mating part is an elastic ball plunger or a ball embedded in the optical substrate, the light source substrate or the light source base.

6. The optical detection device according to claim 3, characterized in that: The laser module further includes a heating element, a temperature sensor and a temperature switch. The light source base is provided with an assembly groove or an assembly hole, and the heating element, the temperature sensor and the temperature switch are installed in the assembly groove.

7. A sample analyzer, characterized in that the sample analyzer includes the optical detection device according to any one of claims 1-6.

Images