Optical detection device and protein detection device using the same

Abstract

The application discloses an optical detection device and a protein detection device using the same. The optical detection device comprises a light source and a cuvette. The light source is used for emitting a convergent light beam. The cuvette is arranged on the light path of the convergent light beam and is arranged in an inclined manner with respect to the optical axis of the convergent light beam. In this way, the application can reduce the re-reflection of the light beam back to the light source, reduce the loss of the light source and prolong the service life of the light source.

Description

Technical Field

[0001] The present invention relates to the field of biological detection, and in particular to an optical detection device and a protein detection device using the same. Background Art

[0002] Specific protein detection has been a very popular clinical test item in recent years, including CRP and SAA, and its detection principle is optical colorimetry.

[0003] Existing detection devices generally include a light source and a colorimetric cell. The light source is used to emit a parallel light beam that is incident vertically into the colorimetric cell, causing part of the parallel light beam to be reflected by the cell wall along the original path and re-enter the light source, thereby damaging the light source, affecting the output power of the light source, and further affecting the stability of the detection, and shortening the life of the light source. Summary of the Invention

[0004] The present invention mainly provides an optical detection device and a protein detection device using the same, so as to solve the problem in the prior art that the light source is damaged due to the reflection of parallel light beams.

[0005] In order to solve the above technical problems, a technical solution adopted by the present invention is: to provide an optical detection device, which includes a light source and a colorimetric cell, the light source is used to emit a convergent light beam, and the colorimetric cell is arranged in the optical path of the convergent light beam and is inclined to the optical axis of the convergent light beam.

[0006] According to one embodiment provided by the present invention, the detection device also includes a transmitted light collector and / or a scattered light collector, the transmitted light collector is arranged on the optical axis of the convergent light beam and is used to collect the light beam transmitted after passing through the colorimetric cell, and the light collection channel of the scattered light collector is at a preset angle to the optical axis of the convergent light beam and is used to collect the light beam scattered after passing through the colorimetric cell.

[0007] According to an embodiment of the present invention, the detection device further includes a first aperture, which includes a transmitted light hole. The transmitted light hole is arranged between the colorimetric cell and the transmitted light collector and is located at the waist position of the convergent light beam.

[0008] According to an embodiment of the present invention, the transmission light hole is a circular light hole, and the diameter of the transmission light hole is equal to the beam waist diameter of the convergent light beam.

[0009] According to an embodiment of the present invention, the first aperture further includes a scattered light hole, which is disposed between the colorimetric cell and the scattered light collector, and is an elliptical light hole.

[0010] According to one embodiment provided by the present invention, the optical detection device further includes a first extinction groove and a first lens sequentially arranged between the transmitted light hole and the transmitted light collector, and a second extinction groove and a second lens sequentially arranged between the scattered light hole and the scattered light collector.

[0011] According to an embodiment of the present invention, the optical detection device further includes a second aperture and a third aperture sequentially arranged between the light source and the colorimetric cell.

[0012] According to an embodiment of the present invention, the aperture of the second aperture is larger than the aperture of the third aperture.

[0013] According to an embodiment of the present invention, the optical detection device further includes a substrate, and the light source, the colorimetric cell, the transmitted light collector, and the scattered light collector are all disposed on the substrate.

[0014] In order to solve the above technical problems, another technical solution adopted by the present invention is: providing a protein detection device, which includes any one of the above-mentioned optical detection devices.

[0015] The beneficial effects of the present invention are: different from the prior art, the light source emits a convergent light beam, so that most of the light beams incident on the colorimetric cell are not vertically incident, thereby reducing the original path reflection of the convergent light beam by the colorimetric cell, and further by tilting the optical axis of the colorimetric cell and the convergent light beam, the original path reflection of the convergent light beam by the colorimetric cell can be further reduced, thereby reducing the light beam reflected by the colorimetric cell from entering the light source, thereby reducing the loss of the light source and thus improving the life of the light source. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the following briefly introduces the drawings required for describing the embodiments. Obviously, the drawings described below are only some embodiments of the present invention. Those skilled in the art can also derive other drawings based on these drawings without inventive work, among which:

[0017] Figure 1 1 is a schematic structural diagram of a first embodiment of an optical detection device provided by the present invention;

[0018] Figure 2 is a schematic structural diagram of a second embodiment of the optical detection device provided by the present invention;

[0019] Figure 3 is a schematic structural diagram of a third embodiment of the optical detection device provided by the present invention;

[0020] Figure 4is a schematic structural diagram of a fourth embodiment of an optical detection device provided by the present invention;

[0021] Figure 5 is a schematic structural diagram of a fifth embodiment of an optical detection device provided by the present invention;

[0022] Figure 6 is a schematic structural diagram of a sixth embodiment of an optical detection device provided by the present invention;

[0023] Figure 7 It is a structural schematic diagram of the seventh embodiment of the optical detection device provided by the present invention. DETAILED DESCRIPTION

[0024] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. All other embodiments obtained by ordinary technicians in this field based on the embodiments of the present invention without making any creative efforts shall fall within the scope of protection of the present invention.

[0025] It should be noted that if the embodiments of the present invention involve directional indications (such as up, down, left, right, front, back, etc.), the directional indications are only used to explain the relative position relationship, movement status, etc. between the various components under a certain specific posture (as shown in the accompanying drawings). If the specific posture changes, the directional indications will also change accordingly.

[0026] In addition, if there are descriptions involving "first", "second", etc. in the embodiments of the present invention, the descriptions of "first", "second", etc. are only for descriptive purposes and cannot be understood as indicating or implying their relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features specified as "first" and "second" may explicitly or implicitly include at least one of such features. In addition, the technical solutions between the various embodiments can be combined with each other, but this must be based on the fact that ordinary technicians in this field can implement them. When the combination of technical solutions is contradictory or cannot be implemented, it should be deemed that such a combination of technical solutions does not exist and is not within the scope of protection required by the present invention.

[0027] Please also refer to Figure 1-Figure 7 The present invention provides an optical detection device 10, comprising a light source 100 and a cuvette 200. The light source 100 is configured to emit a convergent light beam, and the cuvette 200 is disposed in the optical path of the convergent light beam and at an angle to the optical axis of the convergent light beam. Specifically, a light-entering sidewall 210 of the cuvette 200, facing the light source 100, is disposed at an angle to the optical axis of the convergent light beam.

[0028] It should be noted that Figure 1 The convergent beam shown is a cross-sectional view. In the stereoscopic view, multiple beams of the convergent beam converge around the optical axis. Specifically, the light source 10 can be an independent light source capable of emitting a convergent beam, or a light source comprising a light emitter and a lens capable of emitting parallel beams.

[0029] Specifically, a converging light beam refers to a plurality of light rays converging at a point or a smaller area in the direction of propagation. This point or this area can be called the waist position of the converging light beam.

[0030] like Figure 1 As shown, in a specific embodiment, the colorimetric cell 200 as a whole can be a regular cylinder, and the entire colorimetric cell 200 is arranged at an inclined angle relative to the optical axis.

[0031] like Figure 2 As shown, in another specific embodiment, the light incident side wall 210 of the colorimetric cell 200 has a certain inclination angle relative to the bottom wall 220 of the colorimetric cell 200, so that when the colorimetric cell 200 is placed horizontally relative to the optical axis as a whole, the light incident side wall 210 is set at an inclination angle with the optical axis.

[0032] like Figure 1 and Figure 2 As shown, the tilt angle α is greater than or equal to 1° and less than or equal to 5°.

[0033] In the above embodiment, the light source 100 emits a convergent light beam, so that most of the light beam entering the cuvette 200 is not incident vertically, thereby reducing the original path reflection of the convergent light beam by the cuvette 200. Furthermore, by tilting the cuvette 200 and the optical axis of the convergent light beam, the original path reflection of the convergent light beam by the cuvette 200 can be further reduced, thereby reducing the light beam reflected by the cuvette 200 from entering the light source 100, thereby reducing the loss of the light source 100 and improving the life of the light source 100. Furthermore, if the light beam is reflected into the light source 100, it will directly affect the stability of the output power of the light source 100, and thus affect the stability of the entire detection result. The present invention reduces the light beam reflection entering the light source 100, thereby reducing the impact of the light beam on the light source 100, ensuring that the light source 100 continuously outputs a light beam of stable power, thereby improving the stability of the detection result.

[0034] See also Figure 3The optical detection device 10 also includes a transmitted light collector 300 and / or a scattered light collector 400. Specifically, there may be only the transmitted light collector 300, only the scattered light collector 400, or both the transmitted light collector 300 and the scattered light collector 400. No specific limitation is given here. The transmitted light collector 300 is arranged on the optical axis of the convergent light beam and is used to collect the light beam transmitted after passing through the cuvette 200, and can generate a transmission electrical signal based on the collected light beam. The light collection channel of the scattered light collector 400 is at a preset angle to the optical axis of the convergent light beam and is used to collect the light beam scattered after passing through the cuvette 200, and can generate a scattered electrical signal based on the collected light beam.

[0035] In a specific scenario, the detection of the solution in the colorimetric cell 200 generally includes a scattering method and a transmission method. The scattering method is suitable for scenarios with low solution concentrations, and the transmission method is suitable for scenarios with high solution concentrations.

[0036] In a specific embodiment, the transmitted light signal generated by the transmitted light collector 300 and the scattered light signal generated by the scattered light collector 400 are used to obtain the transmission concentration value and the scattered light concentration value of the solution in the cuvette 200, respectively. The transmitted concentration value and the scattered light concentration value are compared with a preset concentration value. If the transmission concentration value and the scattered light concentration value are higher than the preset concentration value, that is, the solution can be considered to have a high value, the transmission concentration value is used as the final detection result. If the transmission concentration value and the scattered light concentration value are lower than the preset concentration value, that is, the solution can be considered to have a low value, the scattered light concentration value is used as the final detection result.

[0037] In the above embodiment, by setting a transmitted light collector 300 for collecting the light beam transmitted after passing through the colorimetric cell 200 and setting a scattered light collector 400 for collecting the light beam scattered after passing through the colorimetric cell 200, the transmitted concentration value and the transmitted concentration value of the solution in the colorimetric cell 200 can be detected, and further, the transmitted concentration value or the scattered concentration value can be selected as the final detection result according to the detection result, thereby ensuring that whether it is a high-concentration solution or a low-concentration solution, the optimal detection result can be guaranteed.

[0038] See also Figure 4 The optical detection device 10 further includes a first aperture 500 , which includes a transmitted light hole 510 , and the transmitted light hole 510 is disposed between the cuvette 200 and the transmitted light collector 300 and is located at the beam waist position of the convergent light beam.

[0039] like Figure 4As shown, when the convergent light beam enters the cuvette 200, a portion of it will directly transmit the cuvette 200 and be transmitted along the original light path, and a portion of it will be scattered by the solution in the cuvette 200. For the transmitted light collector 300, the light beam that needs to be collected is the portion that directly transmits the cuvette 200, and a transmitted electrical signal is generated based on the light beam. If the stray light scattered by the inner wall of the cuvette 200 is collected by the transmitted light collector 300, since the stray light does not carry any signal of the solution in the cuvette 200, it will affect the accuracy of the transmitted electrical signal and ultimately affect the detection result. The present invention adopts a converging light beam and sets a transmitted light hole 510 at the beam waist position of the converging light beam. Since the optical path of the converging light beam to the beam waist position is gradually narrowed, unlike a parallel light path, the narrowing of the optical path means that less stray light can be parallel to the optical path. Furthermore, by setting the transmitted light hole 510 at the beam waist position, only light along the optical path of the original converging light beam can pass through the transmitted light hole 510 and be collected by the transmitted light collector 300, which is sufficient to block most of the stray light, thereby reducing the stray light collected by the transmitted light collector 300 and greatly improving the accuracy of the detection results.

[0040] In a specific embodiment, the transmission light hole 510 can be a circular light hole, and the diameter of the transmission light hole 510 is equal to the beam waist diameter of the convergent light beam.

[0041] In other embodiments, the diameter of the transmission light hole 510 may be reduced according to the intensity of light to be collected by the transmission light collector 300 .

[0042] In other embodiments, the diameter of the transmission light hole 510 may be further increased according to the assembly tolerance, which is not limited here.

[0043] like Figure 4 As shown, the first aperture 500 also includes a scattered light aperture 520, which is disposed between the cuvette 200 and the scattered light collector 400. The scattered light aperture 520 is an elliptical aperture. The long axis of the scattered light aperture is determined by the upper and lower limits of the scattered light to be collected by the scattered light collector 400, while the short axis of the scattered light aperture is equal to the diameter of the convergent light beam when it enters the cuvette 200.

[0044] By providing the scattered light hole 520 , the scattered light entering the scattered light collector 400 through the scattered light hole 520 can meet a certain angle consistency, thereby improving the accuracy of the detection result.

[0045] like Figure 5 As shown, the optical detection device 10 further includes a first extinction groove (not shown), a first lens 610 , a second extinction groove (not shown) and a second lens 620 .

[0046] The first extinction groove and the first lens 610 are sequentially arranged between the transmitted light hole 510 and the transmitted light collector 300. The first extinction groove and the first lens 610 cooperate to further eliminate stray light entering the transmitted light collector 300. Furthermore, by setting the first lens 610, the light spot entering the transmitted light collector 300 can also be controlled, that is, the size of the light spot can be constrained so that the light spot has a better shape and size when collected by the transmitted light collector 300.

[0047] The second extinction groove and the second lens 620 are sequentially arranged between the scattered light hole 520 and the scattered light collector 400. The second extinction groove and the second lens 620 cooperate to eliminate stray light entering the transmitted light collector 300 and can constrain the size of the light spot to improve the accuracy of the detection results.

[0048] like Figure 6 As shown, the optical detection device 10 further includes a second aperture 710 and a third aperture 720 sequentially disposed between the light source 100 and the cuvette 200 , and the aperture diameter of the second aperture 710 is larger than that of the third aperture 720 .

[0049] In a specific embodiment, the distance between the aperture of the second aperture 710 and the light source 100 is greater than or equal to 5 mm and less than or equal to 10 mm. Specifically, the distance between the aperture of the second aperture 710 and the light exit hole of the light source 100 is greater than or equal to 5 mm and less than or equal to 10 mm. Specifically, the distance can be 5 mm, 7 mm, or 10 mm, which is not specifically limited here.

[0050] The distance between the aperture of the third aperture 720 and the aperture of the second aperture 710 is greater than or equal to 30 mm and less than or equal to 40 mm. Specifically, it can be 30 mm, 35 mm, or 40 mm, and is not specifically limited here. The distance between the aperture of the cuvette 200 and the aperture of the third aperture 720 is greater than or equal to 2 mm and less than or equal to 5 mm. Specifically, it can be 2 mm, 4 mm, or 5 mm, and is not specifically limited here.

[0051] Specifically, by ensuring that the apertures of the second aperture 710 and the third aperture 720 are consistent with the changes in the optical path of the convergent light beam, the convergent light beam can be constrained. Furthermore, stray light generated by the light source 100 itself or the optical cavity between the light source 100 and the third aperture 720 can be reduced from entering the cuvette 200. Furthermore, due to the smaller aperture of the third aperture 720, the effect of stray light reflected from the cuvette 200 and the transmitted light collector 300 on the light source 100 can be further reduced, thereby protecting the light source 100.

[0052] like Figure 7As shown, the optical detection device 10 further includes a base 800, wherein the light source 100, the cuvette 200, the transmitted light collector 300, and the scattered light collector 400 are all disposed on the base 800. In other embodiments, other optical components of the optical detection device 10, such as the first aperture 500, the second aperture 710, the third aperture 720, the first extinction groove, the first lens 610, the second extinction groove, and the second lens 620, may also be disposed on the base 800, and are not limited here.

[0053] The overall structure of the optical detection device 10 is described in a specific scenario:

[0054] The light source 100 emits a convergent light beam, which passes through the second aperture 710 and the third aperture 720 in sequence. The second aperture 710 and the third aperture 720 constrain the convergent light beam through their respective apertures, so that the convergent light beam enters the cuvette 200 with a desired cross-sectional size. Due to a certain inclination between the cuvette 200 and the optical axis of the convergent light beam, the convergent light beam is not easily reflected back to the light source 100 along its original path. In addition, part of the light beam reflected toward the light source 100 is blocked by the second aperture 710 and the third aperture 720, thereby protecting the light source 100. Part of the convergent light beam incident on the cuvette 100 is scattered by the inner wall of the cuvette 100 to form stray light, part directly transmits the cuvette 100 to form transmitted light, and part is affected by the solution in the cuvette 100 to form scattered light.

[0055] Among them, the transmitted light passes through the transmitted light hole 510 of the first aperture 500, the first extinction groove and the first lens 610 in sequence and is then collected by the transmitted light collector 300. Specifically, on the one hand, since the optical path of the convergent light beam gradually narrows during the propagation process, the stray light and scattered light parallel to the convergent light beam can be reduced, and then the transmitted light hole 510 is set at the waist position of the convergent light beam to ensure that only the light beam that coincides with the optical path of the convergent light beam can pass through the transmitted light hole 510. Subsequently, the first extinction groove and the first lens 610 cooperate to further eliminate the stray light entering the transmitted light collector 300, and the light beam is constrained by the first lens 610 so that it has a better shape and size when collected by the transmitted light collector 300. In the above structure, on the one hand, the reflection of the light beam back to the light source 100 can be reduced, thereby protecting the light source 100 and improving the stability of the convergent light beam emitted by the light source 100, thereby improving the detection effect. On the other hand, by processing stray light, etc., it can reduce the stray light, etc. from entering the transmitted light collector 300, thereby reducing the impact of stray light on detection, thereby improving the detection effect.

[0056] The scattered light passes through the scattered light hole 520 of the first aperture 500, the second extinction groove and the second lens 620 in sequence and is then collected by the scattered light collector 400. The scattered light hole 520 can ensure the angle consistency of the scattered light entering the scattered light collector 400, and the second extinction groove and the second lens 620 can reduce stray light, thereby improving the overall detection effect.

[0057] In a specific embodiment, the present invention also provides a method for detecting contamination of the colorimetric cell 200 .

[0058] S11 , the transmitted light collector 300 collects the transmitted light of the preset power light beam emitted by the light source 100 through the cuvette 200 , and obtains a signal intensity according to the transmitted light.

[0059] In a specific scenario, after the diluent is added to the colorimetric cell 200, the light source 100 emits a light beam to the colorimetric cell 200 and passes through the diluent, and is collected by the transmitted light collector 300. The signal intensity is determined based on the collected transmitted light. If the signal intensity is within the first preset range, the power of the light beam emitted by the light source 100 at this time is used as the preset power.

[0060] After the cuvette 200 is put into use, a diluent can be added to the cuvette 200, and a light beam of preset power is emitted through the light source 100. The transmitted light collector 300 collects the transmitted light of the preset power light beam after passing through the cuvette 200, and determines the signal intensity based on the transmitted light.

[0061] S12, determining a threshold range of the signal strength, and determining a detection result according to the threshold range.

[0062] After obtaining the signal strength, the signal strength threshold range can be determined. Specifically, the threshold range includes a first preset range, a second preset range, and a third preset range. The third preset range is the total range of signal strengths that can be obtained by the transmitted light collector 300. The second preset range is within the third preset range and does not overlap with the upper and lower limits of the third preset range. The first preset range is within the second preset range.

[0063] In a specific embodiment, the set of the first preset range can be expressed as [C, D], the set of the second preset range can be expressed as [E, F], and the set of the third preset range can be expressed as [A, B]. Then A<E≤C<D≤F<B.

[0064] If the signal strength is within the first preset range, it indicates that the colorimetric cell 200 is relatively clean. If the signal strength is outside the first preset range and within the second preset range, it indicates that the colorimetric cell 200 is slightly contaminated and automatic cleaning maintenance can be performed on the colorimetric cell 200.

[0065] Furthermore, after the colorimetric cell 200 is automatically cleaned and maintained and the detection process of S11 is repeated, if the signal strength is still outside the first preset range and within the second preset range, it means that the colorimetric cell 200 may be seriously contaminated.

[0066] If the signal intensity is outside the second preset range, it means that the cuvette 200 may be seriously contaminated.

[0067] Through the above embodiments, the present invention can perform contamination detection on the colorimetric cell 200 to determine whether the colorimetric cell 200 can continue to be used, thereby not affecting subsequent detection results.

[0068] In a specific embodiment, the present invention also provides a method of providing the light source 100 .

[0069] In a specific embodiment, a transmitted light collector 300 collects light transmitted through a cuvette 200 from a light beam of a preset power emitted by the light source 100, and determines a signal intensity based on the transmitted light. The cuvette 200 may contain no solution or only a diluent. The signal intensity is then determined to be less than a preset threshold. If the signal intensity is less than the threshold, it indicates that the light source 100 may be damaged and requires repair.

[0070] The present invention also provides a protein detection device, which includes the optical detection device in any of the above embodiments.

[0071] Specifically, the protein detection device can be used to obtain the transmission concentration value and scattered light concentration value of the solution in the colorimetric cell 200 based on the transmission light signal generated by the transmission light collector 300 and the scattered light signal generated by the scattered light collector 400, respectively. The transmission concentration value and the scattered light concentration value are compared with a preset concentration value. If the transmission concentration value and the scattered light concentration value are higher than the preset concentration value, that is, the solution can be considered to have a high value, the transmission concentration value is used as the final detection result. If the transmission concentration value is lower than the preset concentration value, that is, the solution can be considered to have a low value, the scattered light concentration value is used as the final detection result.

[0072] In summary, the present invention provides an optical detection device and a protein detection device using the same. By emitting a convergent light beam from the light source 100, most of the light beam incident on the cuvette 200 is not incident vertically, thereby reducing the original path reflection of the convergent light beam by the cuvette 200. Furthermore, by tilting the cuvette 200 and the optical axis of the convergent light beam, the original path reflection of the convergent light beam by the cuvette 200 can be further reduced, thereby reducing the light beam reflected by the cuvette 200 from entering the light source 100, thereby reducing the loss of the light source 100 and thereby improving the life of the light source 100. Furthermore, by providing a transmitted light collector 300 for collecting the convergent light beam transmitted through the cuvette 200 and providing a scattered light collector 400 for collecting the convergent light beam scattered through the cuvette 200, the solution in the cuvette 200 can be tested for both the transmitted concentration value and the transmitted concentration value, and further, the transmitted concentration value or the scattered concentration value can be selected as the final test result based on the test result, thereby ensuring that the optimal test result can be achieved for both high-concentration and low-concentration solutions. Furthermore, by adopting a converging light beam and setting a transmitted light hole 510 at the beam waist position of the converging light beam, since the optical path of the converging light beam to the beam waist position is gradually narrowed, unlike a parallel light path, the narrowing of the optical path means that less stray light can be parallel to the optical path, and further by setting the transmitted light hole 510 at the beam waist position, only light along the optical path of the original converging light beam can pass through the transmitted light hole 510 and be collected by the transmitted light collector 300, which is sufficient to block most of the stray light, thereby reducing the stray light collected by the transmitted light collector 300 and greatly improving the accuracy of the detection results.

[0073] The above descriptions are merely embodiments of the present invention and are not intended to limit the patent scope of the present invention. Any equivalent structure or equivalent process transformation made using the contents of the present invention's description and drawings, or directly or indirectly applied in other related technical fields, are also included in the patent protection scope of the present invention.

Claims

1. An optical detection device, characterized in that: The detection device includes a light source and a colorimetric cell, wherein the light source is used to emit a convergent light beam, and the colorimetric cell is arranged on the optical path of the convergent light beam and is inclined with respect to the optical axis of the convergent light beam; The detection device further includes a transmitted light collector and / or a scattered light collector, wherein the transmitted light collector is arranged on the optical axis of the convergent light beam and is used to collect the light beam transmitted after passing through the cuvette, and the light collection channel of the scattered light collector forms a preset angle with the optical axis of the convergent light beam and is used to collect the light beam scattered after passing through the cuvette; The detection device further includes a first aperture, the first aperture including a transmission light hole, the transmission light hole is arranged between the colorimetric cell and the transmission light collector and is located at the beam waist position of the convergent light beam; The first aperture further includes a scattered light hole, and the scattered light hole is arranged between the colorimetric cell and the scattered light collector.

2. The optical detection device according to claim 1, characterized in that The transmission light hole is a circular light hole, and the diameter of the transmission light hole is equal to the beam waist diameter of the convergent light beam.

3. The optical detection device according to claim 1, characterized in that The scattered light hole is an elliptical light hole.

4. The optical detection device according to claim 3, characterized in that The optical detection device further includes a first extinction groove and a first lens sequentially arranged between the transmitted light hole and the transmitted light collector, and a second extinction groove and a second lens sequentially arranged between the scattered light hole and the scattered light collector.

5. The optical detection device according to claim 1, characterized in that The optical detection device further includes a second diaphragm and a third diaphragm sequentially arranged between the light source and the colorimetric cell.

6. The optical detection device according to claim 5, characterized in that: The aperture diameter of the second aperture is larger than the aperture diameter of the third aperture.

7. The optical detection device according to claim 1, characterized in that The optical detection device further comprises a substrate, and the light source, the colorimetric cell, the transmitted light collector and the scattered light collector are all arranged on the substrate.

8. A protein detection device, characterized in that: The detection device comprises the optical detection device according to any one of claims 1 to 7.

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