Blood cell analyzer

Abstract

The present invention provides a blood cell analyzer, comprising a frame, a housing, a plurality of pools, a sampling module, and a reagent needle assembly; the housing covers the frame; the plurality of pools are distributed in a straight line or in an arc shape, and the plurality of pools include a specific protein reaction pool and a blood routine test pool; the sampling module is arranged on the frame, and is used to reciprocate relative to the frame to sample and divide the samples into the plurality of pools; the reagent needle assembly is arranged on the frame, and the reagent needle assembly can swing to the specific protein reaction pool or perform a three-axis motion to the specific protein reaction pool. The blood cell analyzer provided by the present invention has a compact structure and is easy to maintain.

Description

Technical Field

[0001] The present invention relates to the technical field of blood cell analysis, and in particular to a blood cell analyzer. Background Art

[0002] Hematology analyzers are now widely used in hospitals at all levels, medical testing laboratories, and regional testing centers due to their fast measurement speed, high accuracy, and small reagent consumption.

[0003] Existing blood cell analyzers have the problems of complex structure, inconvenient assembly and high maintenance cost. Summary of the invention

[0004] The present application provides a blood cell analyzer to solve the technical problems of complex structure, inconvenient assembly and high maintenance cost of blood cell analyzers in the prior art.

[0005] In order to solve the above technical problems, a technical solution adopted by the present application is: to provide a blood cell analyzer, the blood cell analyzer comprising:

[0006] frame;

[0007] A shell covering the frame;

[0008] A plurality of pool bodies, wherein the plurality of pool bodies are distributed in a straight line or in an arc shape, and the plurality of pool bodies include a specific protein reaction pool and a blood routine test pool;

[0009] A sampling module, disposed on the frame, for reciprocating relative to the frame to sample and distribute the samples to the plurality of pools;

[0010] A reagent needle assembly is arranged on the frame, and the reagent needle assembly can perform a swinging motion to correspondingly swing to the specific protein reaction pool or perform a three-axis motion to correspondingly move to the specific protein reaction pool.

[0011] The beneficial effects of the present application are as follows: Different from the prior art, the blood cell analyzer provided by the present invention has a compact structure and is easy to maintain. BRIEF DESCRIPTION OF THE DRAWINGS

[0012] Figure 1 It is a front view of the blood cell analyzer provided in this example of the present invention.

[0013] Figure 2 It is a three-dimensional schematic diagram of a frame of a blood cell analyzer provided in an example of the present invention.

[0014] Figure 3 It is another stereoscopic schematic diagram of the frame of the blood cell analyzer provided in this example of the present invention.

[0015] Figure 4It is a three-dimensional schematic diagram of the blood cell analyzer provided by the present invention.

[0016] Figure 5 It is another stereoscopic schematic diagram of the blood cell analyzer provided in this example of the present invention.

[0017] Figure 6 It is a three-dimensional schematic diagram of the blood cell analyzer provided by the present invention with the upper and lower shells removed.

[0018] Figure 7 1 is an internal top view of a blood cell analyzer provided in one embodiment of the present invention.

[0019] Figure 8 FIG. 1 is an internal top view of a blood cell analyzer provided in another embodiment of the present invention.

[0020] Fig. 9 1 is a top view of a blood cell analyzer in a first state provided by another embodiment of the present invention.

[0021] Fig.10 1 is a top view of a blood cell analyzer in a second state provided by another embodiment of the present invention.

[0022] Fig.11 It is a schematic diagram of the three-dimensional structure of local components in a blood analyzer provided in one embodiment of the present invention.

[0023] Fig.12 yes Fig.11 Schematic diagram of the three-dimensional structure of the refrigerated reagent module with the cover open.

[0024] Fig.13 yes Fig.11 A cross-sectional structural schematic diagram of an embodiment of a refrigerated reagent module is shown in FIG.

[0025] Fig.14 yes Fig.11 Another cross-sectional structural schematic diagram of an embodiment of a refrigerated reagent module is shown in FIG.

[0026] Fig.15 yes Fig.11 A schematic cross-sectional structure diagram of another embodiment of a refrigerated reagent module is shown in FIG.

[0027] Fig.16 yes Fig.12 Schematic diagram of the three-dimensional structure of the reagent bottle shown in FIG.

[0028] Fig.17 It is a three-dimensional structural schematic diagram of a local component in a blood analyzer provided in another embodiment of the present invention.

[0029] Fig.18 It is a three-dimensional structural schematic diagram of a local component in a blood analyzer provided by another embodiment of the present invention.

[0030] Fig.19 It is a schematic diagram of a blood analyzer provided by an embodiment of the present invention with the refrigerated reagent module being pulled out.

[0031] Fig. 20 yes Fig.19 Schematic diagram of the blood analyzer shown in the figure with the refrigerated reagent module pulled out and the cover open.

[0032] Fig.21 yes Fig. 20 Schematic diagram of the local enlarged structure in.

[0033] Fig. 22 It is a schematic diagram of a partial planar structure inside the analyzer provided in an embodiment of the present invention.

[0034] Fig.23 yes Fig. 22 Schematic diagram of the three-dimensional structure of the detection device of the analyzer shown in.

[0035] Fig.24 It is a schematic diagram of a partial three-dimensional structure inside the analyzer provided in an embodiment of the present invention.

[0036] Fig.25 yes Fig.23 A schematic diagram of the three-dimensional structure of the heating component of the detection device shown in FIG.

[0037] Fig.26 yes Fig.25 Schematic diagram of the exploded structure of the heating assembly shown in .

[0038] Fig. 27 yes Fig.26 A schematic diagram of the three-dimensional structure of the heating block of the heating assembly shown in FIG.

[0039] Fig.28 yes Fig.23 A schematic diagram of the three-dimensional structure of the detection component of the detection device shown in FIG.

[0040] Fig.29 yes Fig.28 Schematic diagram of the exploded structure of the detection component shown in . DETAILED DESCRIPTION

[0041] The technical solutions of the following embodiments can be combined with each other.

[0042] Please also read Figure 1-Figure 10 An embodiment of the present invention provides a blood cell analyzer, which includes a frame, a housing, a plurality of pool bodies, a sampling module 50, and a reagent needle assembly 14.

[0043] The outer shell covers the frame, and the plurality of pools are distributed in a straight line or in an arc shape. The plurality of pools include specific protein reaction pools (54, 57) and blood routine test pools (61, 58, 59).

[0044] The sampling module 50 is arranged on the frame, and is used for performing horizontal reciprocating motion and vertical reciprocating motion relative to the frame to collect samples (serum, plasma or whole blood samples) and divide the samples into several pools (61, 54, 57, 58, 59).

[0045] In one embodiment, the reagent needle assembly 14 can be rotatably arranged on the frame, and the reagent needle assembly 14 can perform a rotatable motion to correspondingly rotate to the specific protein reaction pool (54, 57) to add reagent to the specific protein reaction pool (54, 57).

[0046] Fig. 9 , Fig.10 As shown, in another embodiment, the reagent needle assembly 14 is a three-axis motion system, which can perform three-axis motion to move to the specific protein reaction pool (54, 57) to add reagents to the specific protein reaction pool (54, 57).

[0047] Specifically, Figure 7 As shown, when the reagent needle assembly 14 swings, a specific protein reaction pool 54, a specific protein reaction pool 57, a cleaning pool 16, a refrigerated reagent pool 55, and a refrigerated reagent pool 56 are distributed on the swinging track of the reagent needle assembly 14, wherein the specific protein reaction pools may be one, two, or three. When two or three are used to form a double-channel or three-channel detection, the detection speed can be improved. The specific protein reaction pool 54 and the specific protein reaction pool 57 are used to mix and heat the mixed solution of the reagent and the sample. The number of refrigerated reagent pools (55, 56) is not limited, and one, two, or more can be set according to actual detection needs. Figure 8 The four shown etc.

[0048] The blood routine test pool includes a DIFF pool 61, an RBC pool 58, and a WBC pool 59 which are sequentially arranged at the lower side of the sampling module 50. The order of the DIFF pool 61, the specific protein reaction pool 54, the specific protein reaction pool 57, the RBC pool 58, and the WBC pool 59 is not limited, for example Figure 8 As shown in FIG. 1 , the DIFF pool 61 is located between the specific protein reaction pool 57 , the RBC pool 58 and the RBC pool 58 , the WBC pool 59 .

[0049] like Figure 2 As shown, the frame includes a support member 3, a front plate 4, a bottom plate 5, a rear partition plate 6, a right support plate 7, a middle partition plate 8, and a left support plate 9.

[0050] Among them, the support member 3 is installed under the base plate 5 and protrudes from the front plate 4. The support member 3 is used to support the installation of the automatic sampling platform 49. During assembly, the automatic sampling platform 49 is first placed on the support member 3 from top to bottom, and then the screws are fixed on the upper and front parts of the support member 3 to complete the installation of the automatic sampling platform 49 on the support member 3. This installation method is convenient for the assembly and disassembly of the automatic sampling platform 49, and at the same time, the parts for installation and matching are easy to process and the production cost is low.

[0051] A heat dissipation air inlet 5-1 and an air outlet 5-2 are arranged on the right side of the bottom plate 5. A filter is installed on the air inlet 5-1. The air inlet 5-1 and the air outlet 5-2 are arranged on the bottom plate 5 at the same time. While ensuring the heat dissipation effect, it is more convenient for the internal layout of the instrument and makes the internal space utilization rate of the instrument higher.

[0052] The middle partition 8 is vertically connected to the front plate 4, the bottom plate 5, and the rear partition 6. The left support plate 9 and the right support plate 7 are respectively located on the left and right sides of the middle partition 8 and are vertically connected to the front plate 4 and the rear partition 6 to divide the rack into the upper left assembly space, the lower left assembly space, the upper right assembly space, and the lower right assembly space. The sampling module 50 is installed on the middle partition 8 and extends out of the lower right assembly space through the middle opening on the front plate 4.

[0053] The rear partition plate 6 is configured to be concave in shape for accommodating cables and / or pipes.

[0054] like Figure 1 , Figure 4 , Figure 5 As shown, the outer shell includes an upper shell 1, a lower shell 2, a top cover 26, a left door panel 28, a right door panel 22, and a rear cover.

[0055] The upper shell 1 is mounted on the front plate 4 via a hinge, and the upper shell 1 can be flipped up and down around the hinge. When the upper shell 1 is closed, the upper shell 1 is adsorbed and / or snapped onto the front plate 4 via magnetic parts and / or snap parts. The upper shell 1 can be opened only with appropriate human force, and the lower shell 2 covers the automatic sampling platform 49.

[0056] The left door panel 28 and / or the right door panel 22 are mounted on the rear partition 6 via hinges, and are adsorbed and / or snapped onto the rear partition 6 via magnetic parts and / or snap fasteners. When the snap fasteners are manually opened, the left door panel 28 and / or the right door panel 22 can be rotated through the hinges to open or close.

[0057] The top cover 26 is installed on the top of the frame and fixed on the rear partition 6.

[0058] The rear cover is mounted on the rear partition 6, and the left and right corners of the rear cover are respectively provided with reagent interfaces 45 (see Figure 6 ) and waste discharge interface 60 (see Figure 7), which are used to connect external reagent bottles and waste liquid barrels respectively. The rear of the instrument is also provided with a network port and a serial port for related connections. The cavity space formed by the rear partition 6 and the rear cover is used to set the routing paths of various wires and pipelines, which is convenient for the liquid and electrical isolation inside the instrument.

[0059] The upper shell 1, the left door panel 28 and the right door panel 22 can be opened without using tools such as screwdrivers during routine maintenance, which greatly facilitates the inspection and debugging of the staff and is also convenient for assembly.

[0060] like Figure 4 As shown, the upper right assembly space is equipped with a DIFF detection module 10 , an automatic sampling drive circuit board 11 , a pressure detection circuit board 12 , a temperature control circuit board 24 , and an air pump 25 .

[0061] The DIFF detection module 10 , the automatic sampling drive circuit board 11 , and the pressure detection circuit board 12 are arranged close to the front plate 4 . The DIFF detection module 10 is used for five-classification of white blood cells.

[0062] The temperature control circuit board 24 and the air pump 25 are arranged near the rear partition 6. The temperature control circuit board 24 is used to control the temperature of multiple heating bodies in the blood cell analyzer. The multiple heating bodies may include a heating body for heating a specific protein reaction pool (54, 57), a heating body for heating a diluent pipeline, a heating body for heating a specific protein detection pool, a heating body for heating a winding pipe, etc. The air pump 25 is used to recommend a positive pressure or negative pressure required for detection.

[0063] like Figure 4 As shown, the lower right assembly space is equipped with a reagent needle assembly 14, a refrigerated reagent module 15, a cleaning tank 16, a blood routine module 17, a liquid pump module 18, a pressure chamber 19, a first liquid valve module 20, a swab filter 21, and a second liquid valve module 23.

[0064] The reagent needle assembly 14 is installed on the base plate 5, and is used to absorb the reagent in the refrigerated reagent pool (55, 56) and distribute it to the specific protein reaction pool (54, 57), and can also be distributed to the routine blood test pool (61, 58, 59) as needed. Correspondingly, the routine blood test pool (61, 58, 59) is also distributed below the movement track of the reagent needle assembly 14.

[0065] The reagent refrigeration module 15 is installed on the bottom plate 5 and is away from the middle partition plate 8 and close to the right door plate 22 to facilitate the replacement of reagents.

[0066] The cleaning pool 16 is installed on the bottom plate 5 and is located at the side of the refrigerated reagent module 15, and is used to clean the reagent needle of the reagent needle assembly 14. The cleaning pool 16 is used to contain a cleaning liquid, and the cleaning ability of the cleaning liquid is stronger than that of the diluent.

[0067] The routine blood test module 17 is installed on the bottom plate 5 and is provided with the aforementioned RBC pool 58 and WBC pool 59 .

[0068] The liquid pump module 18 is installed on the bottom plate 5 by means of elastic buffer installation and is located between the refrigerated reagent module 15 and the rear partition plate 6, so as to provide the hydraulic power required in the detection.

[0069] The first liquid valve module 20 is disposed on the rear partition plate 6 and is used for on-off control of the pipeline.

[0070] The pressure chamber 19 is fixed by the rear partition 6 and / or the middle partition 8 and is located on the side of the first liquid valve module 20 facing the middle partition 8, and is used to form a positive pressure or negative pressure container.

[0071] The swab filter 21 and the second liquid valve module 23 are arranged on the rear partition plate 6 and are located above the pressure chamber 19 in sequence.

[0072] like Figure 5 As shown, the upper left assembly space is equipped with a driving board 41, a spacer sheet metal, a main control board 42, and a back circuit board 43. The driving board 41, the main control board 42, and the back circuit board 43 are spaced apart to reduce electromagnetic interference.

[0073] The driving board 41 is mounted on the left supporting board 9 , and the control ports of the main electronic components of the instrument are arranged on the driving board 41 for driving various moving components, such as the sampling module 50 and the reagent needle assembly 14 .

[0074] The spacer sheet metal support is fixed to the left support plate 9 to provide a circuit board mounting position.

[0075] The main control board 42 is disposed on the spacer sheet metal, and is used to issue relevant control instructions, receive relevant detection signals, and perform calculations.

[0076] The back circuit board 43 is arranged on the spacer sheet metal and installed vertically with the main control board 42. An IO interface is formed on the upper side of the back circuit board 43 to facilitate control, installation and maintenance.

[0077] like Figure 5 As shown, the lower left assembly space is equipped with a power supply 40, a power heat dissipation module, a power input protection module 27, a hemolytic agent syringe 29, a diluent syringe 30, a sample syringe 31, a reagent presence detection module 32, a third liquid valve module 33, a specific protein reaction pool module 34, a specific protein detection component 35, a diluent heating module 36, a pressure-breaking valve 37, a DIFF pool module 38, and a fourth liquid valve module 39.

[0078] The power supply 40 is installed under the left support plate 9 and close to the rear partition plate 6 to fully and reasonably utilize the internal space of the instrument and at the same time be isolated from the liquid path components at the lower part of the instrument.

[0079] The power cooling module is matched with the rear partition plate 6 for heat dissipation, and the power input terminal and the main switch are arranged on the rear left side of the rear partition plate 6.

[0080] The power input protection module 27 is disposed between the power source 40 and the rear partition 6 to prevent human contact with strong electricity.

[0081] The hemolytic agent syringe 29, the diluent syringe 30, and the sample syringe 31 are arranged close to the rear partition 6 and are located below the power input protection module 27 and the power supply 40, and are used to provide pipeline power for liquid suction and liquid pushing operations.

[0082] The reagent presence detection module 32 is disposed on the bottom plate 5 and is located between the hemolytic agent syringe 29 , the diluent syringe 30 , the sample syringe 31 and the left door plate 28 , and is used to detect the presence or absence of the reagent in the pipeline.

[0083] The third liquid valve module 33 and the fourth liquid valve module 39 are arranged on the middle partition plate 8 for controlling the on-off of the pipeline.

[0084] The specific protein reaction pool module 34 and the DIFF pool module 38 are embedded and assembled on the middle partition plate 8 through the opening on the middle partition plate 8 and extend into the lower right assembly space. The specific protein reaction pool module 34 and the DIFF pool module 38 are respectively provided with a DIFF pool 61 and a specific protein reaction pool 54 and a specific protein reaction pool 57.

[0085] The specific protein detection component 35 and the diluent heating module 36 are installed on the bottom plate 5 or the middle partition plate 8. A specific protein detection pool is provided in the specific protein detection component 35. The specific protein detection pool is connected to the specific protein reaction pool 54 and the specific protein reaction pool 57 through a pipeline for receiving the test liquid prepared by the specific protein reaction pool 54 and the specific protein reaction pool 57 for detection.

[0086] The cut-off valve 37 is installed on the middle partition plate 8 .

[0087] like Figure 6 As shown, the front panel 4 is provided with a fifth liquid valve module 44 , a sixth liquid valve module 52 , a sheath flow injector 46 , a sampling injector 47 , a specific protein reagent injector 48 , a refrigerated reagent injector 51 , an automatic injection platform 49 , and a mixing component 53 .

[0088] The fifth liquid valve module 44 and the sixth liquid valve module 52 are respectively located at the upper left and upper right of the front plate 4 and are used for on-off control of the pipeline.

[0089] The sheath flow syringe 46, the sampling syringe 47, and the specific protein reagent syringe 48 are embedded and assembled on the front plate 4 through the left opening on the front plate 4 and extend into the lower left assembly space to provide pipeline power for liquid suction and liquid pushing operations.

[0090] The refrigerated reagent syringe 13 is embedded and assembled on the front plate 4 through the right opening on the front plate 4 and extends into the lower right assembly space.

[0091] The automatic sample introduction platform 49 is located at the bottom of the front plate 4 and is installed on the support member 3, and is used to transport the test tube rack containing the test tubes into the sampling station.

[0092] The mixing component 53 is located at the middle opening of the front plate 4 and is used to mix the liquid in the test tube.

[0093] In the embodiment of the present invention, the sampling module 50 is mainly composed of a sampling needle, a sampling motion module, a sampling syringe 47, a sampling control component, a sampling cleaning system, etc.

[0094] The sampling motion module comprises a horizontal motion mechanism and a vertical motion mechanism, wherein the horizontal motion mechanism comprises a mounting frame and a driving mechanism for horizontal reciprocating motion, and the vertical motion mechanism comprises a driving mechanism for driving the sampling needle to perform vertical reciprocating motion.

[0095] The sampling needle has a needle-like structure with a cylindrical cavity inside. The vertical motion mechanism is installed on the motion slider of the horizontal motion mechanism to achieve horizontal reciprocating motion and vertical reciprocating motion. The sampling motion module is installed on the partition plate 8 in the instrument and extends to the outside of the front plate 4. The sampling motion module can be guided by a linear slide rail, which can ensure the motion accuracy and reduce the contamination of the reaction detection module caused by debris generated by motion friction.

[0096] The sampling syringe 47 is installed on the front plate 4 and is located in the lower left assembly space of the middle partition plate 8. The sampling syringe 47 mainly provides power for the sampling needle to suck and spit out samples, and cleans the inner wall of the sampling needle at the same time.

[0097] The sampling control component includes a fifth liquid valve module 44, a pipeline and a corresponding driving circuit for controlling the sampling needle to distribute and absorb the sample. The fifth liquid valve module 44 is installed at the upper position of the sampling syringe 47 to facilitate the discharge of bubbles in the sampling syringe 47. The pipeline is connected in series to each functional module.

[0098] The sampling and cleaning system includes a cleaning swab, a liquid pump module 18, a cleaning reagent, a diluent, a diluent syringe 30, a control valve and a pipeline. The cleaning swab is installed on the vertical motion mechanism of the sampling motion module. The sampling swab has a cavity through which an axis passes and two cavity outlets at different heights in the radial direction. The sampling needle moves up and down in the axial cavity. The diluent syringe 30 pushes the diluent into the swab from the radial lower side interface of the swab to clean the outer wall of the sampling needle. The liquid pump module 18 extracts the cleaning reagent from the outlet on the upper part of the swab through the pipeline and discharges it to the waste liquid collection area outside the instrument, thereby achieving the purpose of cleaning the outer wall of the sampling needle.

[0099] In the embodiment of the present invention, the reaction detection module mainly includes a reagent input module, a DIFF module, a specific protein module system, and a routine blood test module, which is composed of five linearly distributed pool bodies and various detection modules. In one embodiment, the DIFF pool 61, the specific protein reaction pool 54, the specific protein reaction pool 57, the RBC pool 58, and the WBC pool 59 are arranged in sequence from the front plate 4 to the rear partition 6. Each pool body is installed on the middle partition 8 on the lower side of the sampling horizontal motion mechanism, and is located in a relatively closed environment of the lower right assembly space, which is beneficial to reduce the influence of dust, temperature, etc. in the external environment of the instrument.

[0100] Among them, the reagent input module mainly includes a reagent interface 45, a reagent presence detection module 32 (optical coupler), a liquid valve module, a reagent syringe, a pipeline, a waste liquid discharge interface 60, etc. The external reagent flows to the reagent syringe (hemolytic agent syringe 29, diluent syringe 30) through the reagent interface 45 and the reagent presence detection module 32, and is finally distributed to each detection module through the liquid valve module. The relevant pipelines are also arranged along a vertically upward gradually rising trend to facilitate the discharge of bubbles. The reagent presence detection module 32 detects the presence of the reagent in the pipeline.

[0101] The DIFF module is used to perform five-classification of white blood cells, and includes a DIFF pool module 38, a drive system, and a DIFF detection module 10. The DIFF pool module 38 and the shear valve 37 are installed from the lower left assembly space to the middle partition 8 through the mounting plate. The shear valve 37 is used to control the on-off of the pipeline from the DIFF pool 61 to the DIFF detection module 10. The DIFF pool module 38 extends into the lower right assembly space, and the shear valve 37 is arranged on the middle partition 8 and located in the lower left assembly space. The DIFF pool module 38 and the shear valve 37 are installed together on a part and then fixed to the middle partition 8. This integration is convenient for assembly, disassembly, and maintenance, and at the same time prevents the overflow of liquid in the DIFF pool from causing short circuit and corrosion to the shear valve 37. The DIFF pool module 38 is provided with a heating function and a reagent preheating function. At the same time, the inflowing reagent is preheated before entering the DIFF pool 61, so that the reagent reaction environment of the DIFF pool 61 is in a constant temperature environment, which is convenient for the stability and accuracy of the test results. The DIFF detection module 10 is arranged on the right support plate, located above the DIFF pool module 38. The distance between the DIFF detection module 10 and the DIFF pool module 38 and the front plate 4 is less than the distance to the rear partition 6, and the distance between the DIFF detection module 10 and the middle partition 8 is less than the distance to the right door plate 22. After the sampling module 50 adds the sample to be tested into the DIFF pool 61, and then adds different reagents to react for a period of time, the reacted sample is pushed into the DIFF detection module 10 for detection through a syringe.

[0102] The specific protein module system is used to detect the specific protein content in the sample. The system mainly consists of: a refrigerated reagent module 15, an external reagent, a reagent needle assembly 14, a specific protein reaction pool 54, a specific protein reaction pool 57, a specific protein detection assembly 35, a cleaning pool 16, a liquid circuit control syringe, a liquid valve module and pipelines, etc.

[0103] One or more reagents are arranged in the refrigerated reagent module 15. In the present embodiment, two reagents are preferably arranged. The refrigerated reagent module 15 can store the reagents at a constant temperature and low temperature. The reagent sampling port, the cleaning pool 16, the specific protein reaction pool 54, and the specific protein reaction pool 57 of the refrigerated reagent module 15 are arranged at a circumferential position, and the rotating shaft of the reagent needle assembly 14 is arranged at the axial position of the circumference. The reagent needle assembly 14 is provided with a reagent needle, which can move vertically and swing in a horizontal arc. The reagent needle takes out the reagent from the refrigerated reagent module 15, adds it to the specific protein reaction pool 54 and the specific protein reaction pool 57, respectively, and then cleans the reagent needle in the cleaning pool 16. The reagent needle also has the same cleaning swab and independent cleaning system as the sampling needle. The addition of reagents through the reagent needle can reduce the impact of the reagent performance reduction caused by the long-term storage of the reagent in the pipeline. The specific protein reaction pool module 34 is fixed to the middle partition plate 8 from the lower left assembly space of the middle partition plate 8 through the mounting plate, and the specific protein reaction pools 54 and 57 extend to the lower right assembly space of the middle partition plate 8. The specific protein reaction pool module 34 has a heating device to keep the specific protein reaction pools 54 and 57 in a constant temperature state; the specific protein detection component 35 is arranged on the bottom plate 5 of the lower left assembly space and close to the specific protein reaction pools 54 and 57 to reduce the interference of vibration, and the specific protein detection component 35 has independent heating and temperature control functions; the specific protein module system also includes a diluent heating module 36, which is used to heat the diluent for cleaning the specific protein detection pool to reduce the influence of the cleaning liquid on the temperature of the specific protein detection pool during low-temperature cleaning. In other embodiments, the specific protein reaction pool 54, the specific protein reaction pool 57, the specific protein detection pool and the diluent heating module 36 can also be integrated into a module with constant temperature heating.

[0104] The blood routine test system mainly includes a WBC pool 59, an RBC pool 58, a pressure system, a second liquid valve module 23, pipelines, etc. The pressure system includes positive pressure, negative pressure and a pressure detection plate 12, which are used to provide positive and negative pressures during the reaction process. In one embodiment: the positive pressure system is built up by the air pump 25, the positive pressure gas storage tank stores the positive pressure gas, and the second liquid valve module 23 is controlled. The air pump 25 is arranged on the upper side of the instrument partition 8 and can be located in the upper right assembly space to reduce the impact of vibration on the performance of the instrument. The second liquid valve module 23 is arranged between the air pump 25 and the pressure chamber 19 in the vertical direction; the negative pressure is built up by the air pump 25, the negative pressure gas storage tank stores the negative pressure gas, and the second liquid valve module 23 and the pipeline are controlled; the second liquid valve module 23 is arranged between the air pump 25 and the pressure chamber 19 in the vertical direction; the positive pressure chamber and the negative pressure chamber are installed on the same horizontal plane, the distance from the bottom plate 5 is less than the distance to the right support plate 7, and the pressure detection plate 12 is arranged on the right support plate 7 near the front plate 4. In other embodiments, positive and negative pressures can be established by an air pump 25, and the pressure chamber 19 can also be cancelled, and the purpose of pressure stability can be achieved by lengthening the pipeline between the valves.

[0105] The waste liquid treatment module includes a liquid pump module 18, a second liquid valve module 23, a waste liquid pipe, and a waste liquid discharge interface 60. The liquid pump module 18 is arranged on the bottom plate 5, the distance from the liquid pump module 18 to the right door plate 22 is smaller than the distance to the middle partition plate 8, and the second liquid valve module 23 is arranged on the right rear partition plate 6 near the liquid pump module 18.

[0106] The blood cell analyzer provided by the invention has a compact structure and is easy to maintain.

[0107] Please also read Figures 11 to 18 , a refrigerated reagent module, which includes a cover, a box body, an air outlet hood, a bracket, a refrigeration base plate, a hinge, a first positioning portion, a second positioning portion, a condensed water guide, thermal insulation cotton, a micro switch, an air inlet hood, a heat dissipation module, a reagent bottle storage module 17 and a cold conduction plate 121.

[0108] The box body includes a bottom wall and a surrounding wall connected to the bottom wall. The space formed by the bottom wall and the surrounding wall is used for refrigerating and storing reagent bottles, such as Fig.12 There are two reagent bottles shown in the figure. Of course, the number of reagent bottles is not limited and can be 1, 3, 5, etc. The box body can be in the shape of a rectangular box body or a circular box body.

[0109] The cover is arranged on the top of the surrounding wall and is used to open or seal the box body. The cover can also be in the shape of a rectangular box body or a circular box body. The cover is provided with a through reagent sampling hole 101. The reagent sampling hole 101 is positioned relative to the bottle mouth of the reagent bottle so that a reagent needle (not shown) can pass through the reagent sampling hole 101 to absorb the reagent in the reagent bottle.

[0110] The condensation water guide is arranged on the inner surface side of the cover plate, and the condensation water guide is arranged on the side of the reagent sampling hole 101 and is offset from the bottle mouth of the reagent bottle to prevent condensed condensation water from dripping into the reagent bottle and contaminating the reagent. The number of condensation water guides is not limited, and can be 1, 2, 3, 4, 5 or 6. When the number is multiple, it can be set around the reagent sampling hole 101.

[0111] In one embodiment, the condensation water guide may be a metal part, such as a metal pin or a metal sphere or a metal protrusion, and the cross-sectional area of ​​its free end may be gradually reduced so that the air liquefies and condenses into water droplets after encountering the condensation water guide and drips down. The reagent sampling hole 101 may be a straight hole or a stepped hole. When the reagent sampling hole 101 is in the shape of a stepped hole, it includes a large hole recessed in the inner surface of the cover plate and a small hole passing through the outer surface of the cover plate. The condensation water guide may be arranged in the large hole to shorten the distance between the external air and the condensation water guide, so that after the external air enters the reagent sampling hole 101, it immediately contacts the colder condensation water guide to liquefy and form condensation water, thereby preventing the external air from carrying heat deep into the box.

[0112] The thermal insulation cotton is attached to the inner surface of the cover plate, and is provided with a through hole aligned with the reagent sampling hole 101. The aperture of the through hole is larger than the diameter of the small hole and smaller than the diameter of the large hole, so that the aperture of the air channel of the reagent sampling hole 101 can be appropriately reduced to better keep cold. The condensation water guide protrudes from the thermal insulation cotton, and the condensation water guide extends into the box body and contacts the cold air in the box body to make its temperature relatively low, and its temperature is lower than the external air around the reagent sampling hole 101. After the external air enters the box body through the reagent sampling hole 101, it will liquefy and form condensation water when encountering the low-temperature condensation water guide. Part of the condensation water will be absorbed and collected by the thermal insulation cotton, and part of the condensation water will drip along the free end of the condensation water guide. An overflow port is provided at the bottom of the box body, and the overflow port is used to connect pipelines and power sources to suck out the condensation water in the box body for discharge.

[0113] The reagent bottle storage module 17 includes a bottom block and a plurality of side blocks arranged in parallel and at intervals, and a receiving groove for receiving the reagent bottle is formed between two adjacent side blocks. The reagent bottle storage module 17 is made of a material with a high thermal conductivity coefficient.

[0114] The box body is supported at a certain height by a bracket. The refrigeration base plate includes a refrigeration block, a refrigeration sheet and a temperature sensor 13. The refrigeration block and the temperature sensor 13 are embedded in the refrigeration base plate, and the refrigeration sheet is attached to the lower surface of the refrigeration block.

[0115] The heat dissipation module is in contact with the refrigeration block and is located in the bracket, and is used to dissipate the heat of the refrigeration base plate. The heat dissipation module may include components such as a heat absorption plate, a heat pipe, heat dissipation fins, and a fan. The two ends of the heat dissipation module are respectively connected to the air inlet cover and the air outlet cover. A dustproof net is provided at the air inlet of the air inlet cover to prevent dust and other debris from entering.

[0116] As 1 Figure 5 As shown, the condensed water guide can be arranged on the inner surface side of the cover plate through the cold conduction plate 121. When the cover plate seals the box body, at least one side block of the reagent bottle storage module 17 abuts against the cold conduction plate 121. Compared with cooling through the air in the box body, cooling through the reagent bottle storage module 17 and the cold conduction plate 121 in sequence can make the condensed water guide cool faster and have a better cooling effect.

[0117] The cover plate can be connected to the box body by rotation or sliding. Fig.11 As shown, when the cover is rotatably connected relative to the case, the refrigerated reagent module also includes a hinge, one side of the hinge is connected to the case, and the other side of the hinge is connected to the cover. The case is provided with a first positioning portion on the side of the hinge, and the cover is provided with a second positioning portion on the side of the hinge. When the cover is rotated and opened relative to the case, the second positioning portion is supported by the first positioning portion so that the cover is positioned and opened relative to the case and maintained at a predetermined position. The first positioning portion and the second positioning portion may both be non-magnetic parts, or one of the first positioning portion and the second positioning portion may be a magnet, and the other may be a magnet or a magnetic metal part so as to be magnetically positioned and opened. When the cover is rotatably connected relative to the case, it may be Fig.17 One-way sliding as shown in , or Fig.18 In the two-way sliding, when the two-way sliding is adopted, the cover is only half opened when the reagent bottle is replaced, and the cold energy loss can be appropriately reduced. When the rotary connection and the one-way sliding connection are used, the cover is fully opened when the reagent bottle is replaced, and the cold energy is easily lost.

[0118] The side of the box body may be provided with an opening groove 105, and the side of the reagent bottle is provided with a guide rib matching the opening groove 105 for easy guidance and fool-proof assembly. The top of the reagent bottle is also provided with a lifting piece for easy removal and placement of the reagent bottle.

[0119] The micro switch is arranged at the buckling end of the box body or the cover plate, and is used to detect the opening or closing state of the cover plate relative to the box body.

[0120] The present invention also provides a blood analyzer, which includes an electrically connected control and information processing module, a sample collection and distribution device, a reagent collection and distribution device, a specific protein measuring device, a blood routine measuring device and the aforementioned refrigerated reagent module.

[0121] The sample collection and distribution device is used to collect samples and distribute the collected samples to the blood routine measurement device. The sample collection and distribution device includes a sample needle and a liquid power device such as a syringe, a quantitative pump, etc. The sample is mainly a blood-related sample

[0122] The reagent collection and distribution device is used to collect reagents and distribute the collected reagents to the specific protein measuring device. The reagent collection and distribution device includes a reagent needle and a liquid power device such as a syringe, a quantitative pump, etc. The reagent can be an antibody reagent, a hemolytic reagent, etc.

[0123] The blood routine measurement device is used to provide a measurement location for the allocated sample, measure the allocated sample for the purpose of obtaining at least one blood routine parameter and output the measurement result.

[0124] The specific protein measuring device is used to provide a measurement location for the allocated blood, measure the allocated sample for the purpose of obtaining specific protein parameters and output the measurement results.

[0125] The refrigerated reagent module is used to provide a low-temperature storage environment for the reagent.

[0126] The liquid circuit support device provides liquid circuit support for the sample collection and distribution device, the reagent collection and distribution device, the blood routine measurement device and the specific protein measurement device.

[0127] The control and information processing module is used to control the sample collection and distribution device to collect samples and distribute samples, control the reagent collection and distribution device to collect reagents and distribute reagents, control the liquid circuit support module to transport fluids, receive the measurement results output by the specific protein measurement device and process the measurement results. Preferably, the liquid circuit support device includes a reagent transport pipeline, and the reagent transport pipeline is connected to the reagent bottle in the refrigerated reagent module.

[0128] Preferably, the fluid circuit support device comprises a reagent transport pipeline, and the reagent transport pipeline is connected to a reagent needle in the reagent collection and distribution device.

[0129] Preferably, the blood analyzer also includes a routine blood test device.

[0130] Please also read Figures 11 to 21 The present invention also provides a refrigerated reagent module, which includes a cover plate, a box body and a bracket.

[0131] The box body includes a bottom wall and a surrounding wall connected to the bottom wall. The space formed by the bottom wall and the surrounding wall is used for refrigerating and storing reagent bottles, such as Figure 2 There are two reagent bottles shown in the figure. Of course, the number of reagent bottles is not limited and can be 1, 3, 5, etc. The box body can be in the shape of a rectangular box body or a circular box body.

[0132] The cover is arranged on the top of the surrounding wall and is used to open or seal the box body. The cover can also be in the shape of a rectangular box body or a circular box body. The cover is provided with a through reagent sampling hole 101. The reagent sampling hole 101 is positioned relative to the bottle mouth of the reagent bottle so that a reagent needle (not shown) can pass through the reagent sampling hole 101 to absorb the reagent in the reagent bottle.

[0133] A first movable fitting 71 is provided at the bottom edge of the bracket, which may be a guide rail or a pulley, etc. A first sensing component is provided at the inner end of the bracket for sensing the advancement status. A handle 72 is provided on the outer side of the bracket to facilitate pulling out and pushing in operations of the bracket.

[0134] The refrigerated reagent module also includes an air outlet hood, a refrigeration base plate, a hinge, a first positioning portion, a second positioning portion, a condensed water guide, thermal insulation cotton, a micro switch, an air inlet hood, a heat dissipation module, a reagent bottle storage module 17 and a cold conduction plate 121.

[0135] The condensation water guide is arranged on the inner surface side of the cover plate, and the condensation water guide is arranged on the side of the reagent sampling hole 101 and is offset from the bottle mouth of the reagent bottle to prevent condensed condensation water from dripping into the reagent bottle and contaminating the reagent. The number of condensation water guides is not limited, and can be 1, 2, 3, 4, 5 or 6. When the number is multiple, it can be set around the reagent sampling hole 101.

[0136] The condensation water guide can be a metal part, such as a metal pin, and the cross-sectional area of ​​its free end can be gradually reduced so that the air can liquefy and condense into water droplets after encountering the condensation water guide and drip down. The reagent sampling hole 101 can be a straight hole or a stepped hole. When the reagent sampling hole 101 is in the shape of a stepped hole, it includes a large hole recessed in the inner surface of the cover plate and a small hole that passes through the outer surface of the cover plate. The condensation water guide can be arranged in the large hole to shorten the distance between the external air and the condensation water guide, so that after the external air enters the reagent sampling hole 101, it immediately contacts the colder condensation water guide to liquefy and form condensation water, thereby preventing the external air from carrying heat deep into the box.

[0137] The thermal insulation cotton is attached to the inner surface of the cover plate, and is provided with a through hole aligned with the reagent sampling hole 101. The aperture of the through hole is larger than the diameter of the small hole and smaller than the diameter of the large hole, so that the aperture of the air channel of the reagent sampling hole 101 can be appropriately reduced to better keep cold. The condensation water guide protrudes from the thermal insulation cotton, and the condensation water guide extends into the box body and contacts the cold air in the box body to make its temperature relatively low, and its temperature is lower than the external air around the reagent sampling hole 101. After the external air enters the box body through the reagent sampling hole 101, it will liquefy and form condensation water when encountering the low-temperature condensation water guide. Part of the condensation water will be absorbed and collected by the thermal insulation cotton, and part of the condensation water will drip along the free end of the condensation water guide. An overflow port is provided at the bottom of the box body, and the overflow port is used to connect pipelines and power sources to suck out the condensation water in the box body for discharge.

[0138] The reagent bottle storage module 17 includes a bottom block and a plurality of side blocks arranged in parallel and at intervals, and a receiving groove for receiving the reagent bottle is formed between two adjacent side blocks. The reagent bottle storage module 17 is made of a material with a high thermal conductivity coefficient.

[0139] The box body is supported at a certain height by a bracket. The refrigeration base plate includes a refrigeration block, a refrigeration sheet and a temperature sensor 13. The refrigeration block and the temperature sensor 13 are embedded in the refrigeration base plate, and the refrigeration sheet is attached to the lower surface of the refrigeration block.

[0140] The heat dissipation module is in contact with the refrigeration block and is located in the bracket, and is used to dissipate the heat of the refrigeration base plate. The heat dissipation module may include components such as a heat absorption plate, a heat pipe, heat dissipation fins, and a fan. The two ends of the heat dissipation module are respectively connected to the air inlet cover and the air outlet cover. A dustproof net is provided at the air inlet of the air inlet cover to prevent dust and other debris from entering.

[0141] like Figure 5 As shown, the condensed water guide can be arranged on the inner surface side of the cover plate through the cold conduction plate 121. When the cover plate seals the box body, at least one side block of the reagent bottle storage module 17 abuts against the cold conduction plate 121. Compared with cooling through the air in the box body, cooling through the reagent bottle storage module 17 and the cold conduction plate 121 in sequence can make the condensed water guide cool faster and have a better cooling effect.

[0142] The cover plate can be connected to the box body by rotation or sliding. Figure 1 As shown, when the cover is rotatably connected relative to the case, the refrigerated reagent module also includes a hinge, one side of the hinge is connected to the case, and the other side of the hinge is connected to the cover. The case is provided with a first positioning portion on the side of the hinge, and the cover is provided with a second positioning portion on the side of the hinge. When the cover is rotated and opened relative to the case, the second positioning portion is supported by the first positioning portion so that the cover is positioned and opened relative to the case and maintained at a predetermined position. The first positioning portion and the second positioning portion may both be non-magnetic parts, or one of the first positioning portion and the second positioning portion may be a magnet, and the other may be a magnet or a magnetic metal part so as to be magnetically positioned and opened. When the cover is rotatably connected relative to the case, it may be Figure 7 One-way sliding as shown in , or Figure 8 In the two-way sliding, when the two-way sliding is adopted, the cover is only half opened when the reagent bottle is replaced, and the cold energy loss can be appropriately reduced. When the rotary connection and the one-way sliding connection are used, the cover is fully opened when the reagent bottle is replaced, and the cold energy is easily lost.

[0143] The side of the box body may be provided with an opening groove 105, and the side of the reagent bottle is provided with a guide rib matching the opening groove 105 for easy guidance and fool-proof assembly. The top of the reagent bottle is also provided with a lifting piece for easy removal and placement of the reagent bottle.

[0144] The micro switch is arranged at the buckling end of the box body or the cover plate, and is used to detect the opening or closing state of the cover plate relative to the box body.

[0145] The present invention also provides a blood analyzer, which includes the aforementioned refrigerated reagent module and a main box 200. The main box 200 includes a top plate 201, a panel 202, a back plate, a side plate 204 and a bottom plate 5 that are connected to each other. The side plate 204 is provided with an opening. A second movable matching member, such as a guide rail or a guide groove, is provided in the main box 200 corresponding to the first movable matching member 71, and a matching second sensor component is provided corresponding to the first sensor component 73 to detect the pushing into place of the bracket. After the bracket is pulled out in the X direction by the handle 72, the cover plate can be opened in the Y direction relative to the box body, and the extension direction of the corresponding hinge is parallel to the pulling direction, or when the cover plate is slidably connected relative to the box body, the sliding opening direction can be set to be perpendicular to the pulling direction. It has a compact structure and is easy to operate.

[0146] The blood analyzer also includes an electrically connected control and information processing module, a sample collection and distribution device, a reagent collection and distribution device, a specific protein measuring device, a blood routine measuring device and the aforementioned refrigerated reagent module.

[0147] The sample collection and distribution device is used to collect samples and distribute the collected samples to the blood routine measurement device. The sample collection and distribution device includes a sample needle and a liquid power device such as a syringe, a quantitative pump, etc. The samples are mainly blood-related samples.

[0148] The reagent collection and distribution device is used to collect reagents and distribute the collected reagents to the specific protein measuring device. The reagent collection and distribution device includes a reagent needle and a liquid power device such as a syringe, a quantitative pump, etc. The reagent can be an antibody reagent, a hemolytic reagent, etc., including but not limited to an immune reagent, such as a CRP reagent, a SAA reagent, a ferritin reagent, etc.

[0149] The blood routine measurement device is used to provide a measurement location for the allocated sample, measure the allocated sample for the purpose of obtaining at least one blood routine parameter and output the measurement result.

[0150] The specific protein measuring device is used to provide a measurement location for the assigned sample, measure the assigned sample for the purpose of obtaining specific protein parameters and output the measurement result, and the sample is mainly a blood-related sample.

[0151] The refrigerated reagent module is used to provide a low-temperature storage environment for the reagent.

[0152] The liquid circuit support device provides liquid circuit support for the sample collection and distribution device, the reagent collection and distribution device, the blood routine measurement device and the specific protein measurement device.

[0153] The control and information processing module is used to control the sample collection and distribution device to collect samples and distribute samples, control the reagent collection and distribution device to collect reagents and distribute reagents, control the liquid circuit support module to transport fluids, receive the measurement results output by the specific protein measurement device and process the measurement results. Preferably, the liquid circuit support device includes a reagent transport pipeline, and the reagent transport pipeline is connected to the reagent bottle in the refrigerated reagent module.

[0154] Preferably, the fluid circuit support device comprises a reagent transport pipeline, and the reagent transport pipeline is connected to a reagent needle in the reagent collection and distribution device.

[0155] The refrigerated reagent module 110 provided in this embodiment has a novel structure, is simple to manufacture, and is convenient to disassemble, assemble, and maintain.

[0156] This embodiment provides a detection device, such as Figure 22 to Figure 27 As shown, the detection device includes a stand 100, a heating component, a specific protein detection component 35 and an optical detection pool 120.

[0157] like Fig.23 As shown, the stand 100 can be made of a metal bracket or a plastic bracket, which is fixedly assembled in the shell of the analyzer. The heating component can be fixed on the stand 100 in an inclined manner. The heating component includes a heating block 110. The heating block 110 can be made of aluminum or copper. The heating block 110 is provided with a plurality of assembly cavities 113 for receiving the optical detection pool 120. The volume of the assembly cavity 113 matches the volume of the optical detection pool 120. The assembly cavity 113 fully surrounds the optical detection pool 120, and only the bottom end surface of the optical detection pool 120 is exposed. The contact area between the heating block 110 and the optical detection pool 120 is large, and the heat conduction effect is good, so that the temperature of the liquid to be tested in the optical detection pool 120 can be well controlled. The specific protein detection component 35 is fixed to the heating block 110 and includes a base 130 having a notch 134 for clamping with the heating block 110 . The optical detection pool 120 is disposed in the notch 134 and is installed in the assembly cavity 113 through the support of the base 130 .

[0158] like Fig.23 , Fig.28 , Fig.29As shown, the heating block 110 is further provided with a light through hole 114 which passes through the assembly cavity 113, the base body 130 is further provided with a light input channel 133, a first light output channel 131 and a second light output channel 132, a notch portion 134 is provided between the light input channel 133 and the first light output channel 131 and the second light output channel 132, the light input channel 133 is aligned with the first light output channel 131, the axis of the second light output channel 132 is inclined relative to the axis of the first light output channel 131, and the light through hole 114 is aligned with the light input channel 133 when the specific protein detection component 35 is fixed to the heating block 110.

[0159] In order to facilitate the fixation of the specific protein detection component 35 to the heating block 110, an assembly plate 136 is integrally extended from the base 130 on one side of the notch portion 134 close to the light entrance channel 133, and a first assembly hole 137 is provided on the assembly plate 136. A first connecting hole 111 is provided on the side wall of the heating block 110 corresponding to the first assembly hole 137. The specific protein detection component 35 can be locked relative to the heating block 110 by passing a screw through the first assembly hole 137 and screwing it into the first connecting hole 111. The first connecting hole 111 is located on the side of the light through hole 114.

[0160] Furthermore, the base 130 is also provided with a second assembly hole 138 extending to the bottom of the notch portion 134, and a second connecting hole 112 is provided at the bottom end of the heating block 110 corresponding to the second assembly hole 138. The specific protein detection component 35 can be locked relative to the heating block 110 by passing a screw through the second assembly hole 138 and screwing it into the second connecting hole 112. The second connecting hole 112 is located on the side of the assembly cavity 113.

[0161] In the embodiment of the present invention, the assembly cavity 113 is a plurality of assembling cavities 113 arranged in parallel and at intervals, for example Fig.23 As shown in the figure, there are 6 specific protein detection components 35 and optical detection pools 120, and multiple groups of guide ribs 115 are arranged in parallel and at intervals on the side walls of the heating block 110 so that the notch 134 of the base 130 and the assembly plate 136 can be aligned and clamped with the heating block 110, and the extension direction of the guide ribs 115 is parallel to the extension direction of the assembly cavity 113.

[0162] like Fig.23 and Fig.25 The detection device also includes a waterproof sealing ring, the optical detection pool 120 includes an injection tube 125, and the top of the heating block 110 is provided with a through hole 116 which is connected to the assembly cavity 113 to allow the injection tube 125 to extend out. The waterproof sealing ring is located in the assembly cavity 113 and is sleeved on the outer periphery of the injection tube 125 and is clamped between the optical detection pool 120 and the heating block 110, thereby preventing external liquid from entering the optical detection pool 120 and affecting the detection result.

[0163] like Fig. 22 and Fig.23As shown, the heating block 110 is tilted and fixed on the stand 100 so that the assembly cavity 113 is tilted, and the optical detection pool 120 and the specific protein detection component 35 are tilted relative to the horizontal plane.

[0164] The detection device also includes a pipe heating component 300, which is used to wrap around the pipe and heat the pipe. The stand 100 includes a first arm 102 and a second arm 104. The heating block 110 is fixed by the first arm 102. The pipe heating component 300 is arranged on the side of the heating block 110 through the second arm 104, and the pipe heating component 300 is lower than the position of the injection tube 125. As a result, the pipe wrapped on the pipe heating component 300 can be led out with a smaller curvature and connected to the injection tube 125, which facilitates the discharge of bubbles and reduces the bubble problem. If the pipe heating component 300 is higher than the position of the injection tube 125, the pipe wrapped on the pipe heating component 300 can be led out with a larger curvature and connected to the injection tube 125, and the bubbles are not easy to be discharged, which will cause relatively serious bubble problems.

[0165] like Figure 25 to Figure 27 As shown, the heating assembly also includes a heating film 117, a temperature sensor 118 and an over-temperature protection switch 119. The heating block 110 can be made of a material with good thermal conductivity, such as aluminum or copper. The heating film 117 is attached to the surface of the heating block 110, and the temperature sensor 118 and the over-temperature protection switch 119 are embedded and assembled in the heating block 110. Mounting holes 103 can be set at both ends of the heating block 110 to fix it with the first arm 102 of the stand 100. The surface of the heating block 110 for attaching the heating film 117 can be provided with a protrusion 106. The protrusion 106 makes the cross section of the heating block 110 L-shaped. The over-temperature protection switch 119 can be embedded and assembled in the protrusion 106, thereby making the structure of the heating block 110 compact.

[0166] The detection device provided in this embodiment has a novel structure, and the optical detection pool 120 is arranged in the notch portion 134 and is installed in the assembly cavity through the support of the base 130, which is convenient for disassembly and maintenance, can reduce the impact of water leakage on the detection device, and can reduce the bubble problem. This embodiment also provides a sample analyzer, which includes the above-mentioned detection device.

Claims

1. A blood cell analyzer, characterized in that: The blood cell analyzer comprises: frame; A shell covering the frame; A plurality of pool bodies, wherein the plurality of pool bodies are distributed in a straight line or in an arc shape, and the plurality of pool bodies include a specific protein reaction pool and a blood routine test pool; A sampling module, disposed on the frame, for reciprocating relative to the frame to sample and distribute the samples to the plurality of pools; A reagent needle assembly is disposed on the rack, and the reagent needle assembly can perform a swinging motion to correspondingly swing to the specific protein reaction pool or perform a three-axis motion to correspondingly move to the specific protein reaction pool; Wherein, the frame includes a front plate, a bottom plate, a rear partition plate, a right support plate, a middle partition plate, and a left support plate; The middle partition is vertically connected to the front plate, the bottom plate, and the rear partition; the left support plate and the right support plate are respectively located on the left and right sides of the middle partition and vertically connected to the front plate and the rear partition to divide the rack into an upper left assembly space, a lower left assembly space, an upper right assembly space, and a lower right assembly space; The sampling module is mounted on the middle partition plate and extends out of the lower right assembly space through the middle opening on the front plate; The upper right assembly space is equipped with a DIFF detection module; the lower right assembly space is equipped with the reagent needle assembly and the blood routine module; the lower left assembly space is equipped with a third liquid valve module, the specific protein reaction pool module, the specific protein detection component, the diluent heating module, the pressure-breaking valve, the DIFF pool module, and the fourth liquid valve module; the DIFF pool module is provided with the DIFF pool; The third liquid valve module and the fourth liquid valve module are arranged on the middle partition plate; The specific protein reaction pool module and the DIFF pool module are embedded and assembled on the middle partition through the opening on the middle partition and extend into the lower right assembly space. The specific protein detection component and the diluent heating module are mounted on the bottom plate or the middle partition plate; The pressure cut-off valve is installed on the middle partition plate.

2. The blood cell analyzer according to claim 1, characterized in that: When the reagent needle assembly performs a swinging motion, the specific protein reaction pool, the cleaning pool, and the refrigerated reagent pool are distributed on the swinging track of the reagent needle assembly; The routine blood test pool includes an RBC pool and a WBC pool located at the lower side of the sampling module.

3. The blood cell analyzer according to claim 2, characterized in that: The frame also includes a support member; The support member is installed below the bottom plate and protrudes from the front plate; A heat dissipation air inlet and an air outlet are arranged on the right side of the bottom plate, and a filter is installed on the air inlet.

4. The blood cell analyzer according to claim 3, characterized in that: The rear partition is configured to be concave in shape for accommodating cables and / or pipes.

5. The blood cell analyzer according to claim 3, characterized in that: The housing comprises an upper shell, a lower shell, a top cover, a left door panel, a right door panel, and a rear cover; The upper shell is mounted on the front plate via a hinge, and is adsorbed and / or snapped onto the front plate via a magnetic member and / or a snap member; The left door panel and / or the right door panel are mounted on the rear partition through hinges, and are adsorbed and / or snapped onto the rear partition through magnetic parts and / or snap fasteners; The top cover is installed on the top of the frame; The rear cover is mounted on the rear partition plate, and a reagent interface and a waste liquid discharge interface are respectively provided at the left and right end corner areas of the rear cover.

6. The blood cell analyzer according to claim 3, characterized in that: The upper right assembly space is also equipped with an automatic injection drive circuit board, a pressure detection circuit board, a temperature control circuit board, and an air pump; The DIFF detection module, the automatic sampling drive circuit board, and the pressure detection circuit board are close to the front plate; The temperature control circuit board and the air pump are close to the rear partition.

7. The blood cell analyzer according to claim 3, characterized in that: The lower right assembly space is also equipped with a refrigerated reagent module, the cleaning tank, a liquid pump module, a pressure chamber, a first liquid valve module, a swab filter, and a second liquid valve module; The reagent needle assembly is mounted on the bottom plate; The refrigerated reagent module is mounted on the bottom plate and away from the middle partition; The cleaning tank is installed on the bottom plate and is located on the side of the refrigerated reagent module; The blood routine module is installed on the bottom plate and is provided with the RBC pool and the WBC pool; The liquid pump module is mounted on the bottom plate and is located between the refrigerated reagent module and the rear partition; The first liquid valve module is arranged on the rear partition plate; The pressure chamber is fixed by the rear partition plate and / or the middle partition plate and is located on a side of the first liquid valve module facing the middle partition plate; The swab filter and the second liquid valve module are arranged on the rear partition plate and are located above the pressure chamber in sequence.

8. The blood cell analyzer according to claim 3, characterized in that: The upper left assembly space is equipped with a drive board, a spacer sheet metal, a main control board, and a back circuit board; The driving plate is mounted on the left supporting plate; The spacer sheet metal support is fixed to the left support plate; The main control board is arranged on the spacer sheet metal; The back circuit board is arranged on the spacer sheet metal and is installed vertically with the main control board.

9. The blood cell analyzer according to claim 3, characterized in that: The lower left assembly space is also equipped with a power supply, a power input protection module, a hemolytic agent syringe, a diluent syringe, a sample syringe, and a reagent presence detection module; The power supply is installed below the left support plate and close to the rear partition; The power input protection module is arranged between the power supply and the rear partition; The hemolytic agent syringe, diluent syringe, and sample syringe are arranged close to the rear partition and are located below the power input protection module and the power supply; The reagent presence detection module is arranged on the bottom plate and is located between the hemolytic agent syringe, the diluent syringe, the sample syringe and the left door plate; The specific protein reaction pool module is provided with the specific protein reaction pool.

10. The blood cell analyzer according to claim 3, characterized in that: The front panel is provided with a fifth liquid valve module, a sixth liquid valve module, a sheath flow syringe, a sampling syringe, a specific protein reagent syringe, a refrigerated reagent syringe, an automatic injection platform, and a mixing component; The fifth liquid valve module and the sixth liquid valve module are respectively located at the upper left and upper right of the front plate; The sheath flow syringe, the sampling syringe, and the specific protein reagent syringe are embedded and assembled on the front plate through the left opening of the front plate and extend into the lower left assembly space; The refrigerated reagent syringe is embedded and assembled on the front plate through the right opening on the front plate and extends into the lower right assembly space; The automatic injection platform is located at the bottom of the front plate and is installed on the support member; The mixing component is located at the middle opening on the front plate.

11. The blood cell analyzer according to claim 7, characterized in that: The refrigerated reagent module comprises: A box body, used for storing reagent bottles; A cover plate, used to open or cover the box body, the cover plate is provided with a through reagent sampling hole, and the reagent sampling hole is opposite to the bottle mouth of the reagent bottle; The condensed water guide is arranged on the inner surface side of the cover plate. The condensed water guide is arranged on the side of the reagent sampling hole and is offset from the bottle mouth of the reagent bottle.

12. The blood cell analyzer according to claim 11, characterized in that: The condensed water guide is a metal part; And / or the reagent sampling hole is in the shape of a stepped hole, including a large hole recessed in the inner surface of the cover plate and a small hole penetrating the outer surface of the cover plate, and the condensate guide is arranged in the large hole; and / or the cross-sectional area of ​​the free end of the condensate guide gradually decreases.

13. The blood cell analyzer according to claim 11, characterized in that: The refrigerated reagent module also includes thermal insulation cotton, which is attached to the inner surface of the cover plate, and is provided with a through hole aligned with the reagent sampling hole, and the condensed water guide protrudes from the thermal insulation cotton; and / or an overflow port is provided at the bottom of the box body, and the overflow port is used to discharge the condensed water in the box body.

14. The blood cell analyzer according to claim 11, characterized in that: The reagent refrigeration module also includes a reagent bottle storage module, which includes a plurality of side blocks, and a receiving groove for receiving the reagent bottle is formed between two adjacent side blocks.

15. The blood cell analyzer according to claim 11, characterized in that: The cover is rotatably connected or slidably connected relative to the box body; and / or when the cover is rotatably connected relative to the box body, the refrigerated reagent module also includes a hinge, one side of the hinge is connected to the box body, and the other side of the hinge is connected to the cover plate; and / or the box body is provided with a first positioning portion on the side of the hinge, and the cover plate is provided with a second positioning portion on the side of the hinge, when the cover plate is rotated open relative to the box body, the second positioning portion is supported by the first positioning portion so that the cover plate is positioned open relative to the box body and maintained at a predetermined position; and / or the first positioning portion and the second positioning portion are both non-magnetic parts, or one of the first positioning portion and the second positioning portion is a magnet, and the other is a magnet or a magnetic metal part.

16. The blood cell analyzer according to claim 9, characterized in that: The blood cell analyzer comprises: Stand; A heating assembly is fixed on the stand, the heating assembly comprises a heating block, and the heating block is provided with an assembly cavity for receiving an optical detection cell; The specific protein detection component is fixed to the heating block, and the specific protein detection component includes a base body, and the base body is provided with a notch part that is clamped and matched with the heating block; The optical detection pool is arranged in the notch and is installed in the assembly cavity through the support of the base.

17. The blood cell analyzer according to claim 16, characterized in that: The heating block is also provided with a light hole passing through the assembly cavity, the base is also provided with a light input channel, a first light output channel and a second light output channel, the notch is provided between the light input channel and the first light output channel and the second light output channel, the light input channel is aligned with the first light output channel, the axis of the second light output channel is inclined relative to the axis of the first light output channel, and the light hole is aligned with the light input channel when the specific protein detection component is fixed to the heating block.

18. The blood cell analyzer according to claim 17, characterized in that: The base body is integrally extended with an assembly plate on one side of the notch portion close to the light entrance channel, the assembly plate is provided with a first assembly hole, the side wall of the heating block is provided with a first connecting hole corresponding to the first assembly hole, and the first connecting hole is located on the side of the light through hole.

19. The blood cell analyzer according to claim 17, characterized in that: The blood cell analyzer also includes a waterproof sealing ring, the optical detection cell includes a cell body and an injection tube, the top of the heating block is provided with a through hole connected to the assembly cavity to allow the injection tube to extend out, the waterproof sealing ring is located in the assembly cavity and is sleeved on the outer circumference of the injection tube and is clamped between the optical detection cell and the heating block.

20. The blood cell analyzer according to claim 19, characterized in that: The blood cell analyzer also includes a pipe heating assembly, which is used to wrap around the pipe and heat the pipe. The stand includes a first arm and a second arm. The heating block is fixed by the first arm. The pipe heating assembly is arranged on the side of the heating block by the second arm, and the pipe heating assembly is lower than the injection tube.

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