Surface-modified intraocular lens and preparation method thereof

Abstract

The invention discloses a surface-modified intraocular lens and a preparation method thereof, and relates to the technical field of medical implant materials. The surface-modified intraocular lens is prepared by loading a TGF-beta2 receptor nucleic acid aptamer coated with lactylated chitosan nano-plasmids on the surface of the intraocular lens. The preparation method comprises the following steps: preparing the lactylated chitosan nano-plasmids; constructing a TGF-beta 2 receptor nucleic acid aptamer coated with the lactylated chitosan nano-plasmids; and carrying out surface modification on an artificial lens by using the TGF-beta2 receptor nucleic acid aptamer coated with the lactylated chitosan nano-plasmid. According to the surface-modified intraocular lens provided by the invention, the problems that the loading capacity is small, the effective treatment concentration cannot be maintained for a long time and the biological activity of an TGF-beta2 antibody is difficult to maintain when the TGF-beta2 antibody is directly loaded on the surface of the intraocular lens are solved.

Description

technical field

[0001] The present application relates to the technical field of medical implant materials, in particular to a surface-modified intraocular lens and a preparation method thereof. Background technique

[0002] Posterior lens capsule opacification (PCO) is the main complication affecting the long-term visual recovery of patients after cataract surgery. Generally, laser incision of the opacified posterior capsule of the anterior segment is required for treatment. However, recent studies have shown that the opacity of the posterior lens capsule is also a kind of wound repair response spontaneously produced by the patient's body. Many growth factors, cytokines and inflammatory mediators are involved in this process, and the residual lens epithelial cells (LECs) mainly Growth factors (such as TGF-β2) produced by autocrine regulate their own proliferation, migration and epithelial-mesenchymal transition, and play a central role in the occurrence and development of p...

Examples

Embodiment Construction

[0042]In order to enable those skilled in the art to better understand the solutions of the present application, the technical solutions in the embodiments of the present application will be clearly and completely described below in conjunction with the drawings in the embodiments of the present application. Apparently, the described embodiments are only some of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in this application, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the scope of protection of this application.

[0043] In order to solve the technical problems of directly loading TGF-β2 antibody on the surface of the intraocular lens because of the small amount of loading, the inability to maintain an effective therapeutic concentration for a long time, and the difficulty in maintaining the biological activity of the TGF-β2 antibody, an embodiment of ...

technical field

[0001] The present application relates to the technical field of medical implant materials, in particular to a surface-modified intraocular lens and a preparation method thereof. Background technique

[0002] Posterior lens capsule opacification (PCO) is the main complication affecting the long-term visual recovery of patients after cataract surgery. Generally, laser incision of the opacified posterior capsule of the anterior segment is required for treatment. However, recent studies have shown that the opacity of the posterior lens capsule is also a kind of wound repair response spontaneously produced by the patient's body. Many growth factors, cytokines and inflammatory mediators are involved in this process, and the residual lens epithelial cells (LECs) mainly Growth factors (such as TGF-β2) produced by autocrine regulate their own proliferation, migration and epithelial-mesenchymal transition, and play a central role in the occurrence and development of p...

Examples

Embodiment Construction

[0042]In order to enable those skilled in the art to better understand the solutions of the present application, the technical solutions in the embodiments of the present application will be clearly and completely described below in conjunction with the drawings in the embodiments of the present application. Apparently, the described embodiments are only some of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in this application, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the scope of protection of this application.

[0043] In order to solve the technical problems of directly loading TGF-β2 antibody on the surface of the intraocular lens because of the small amount of loading, the inability to maintain an effective therapeutic concentration for a long time, and the difficulty in maintaining the biological activity of the TGF-β2 antibody, an embodiment of ...

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