Application of perilla leaf extract in preparation of medicine for preventing and treating acute lung injury

Abstract

The invention discloses application of a perilla leaf extract in preparation of a medicine for preventing and treating acute lung injury, and experiments prove that the perilla leaf extract can improve the survival rate of mice, improve weight loss of the mice and relieve edema of tissues such as liver, spleen and lung of the mice; the expression of inflammatory factors can be down-regulated, and a certain inhibition effect on LPS-induced inflammatory storm and immune disorder is achieved. In addition, the perilla leaf extract can also increase the tidal volume and the ventilation volume per minute, and has a certain prevention and treatment effect on LPS-induced respiratory dysfunction; alveolar dilatation and alveolar wall thickening of various animals after LPS caudal vein injection can be obviously relieved, and the lung pathological condition is improved. Therefore, the perilla leaf extract can be applied to preparation of the medicine for preventing and treating the acute lung injury.

Description

technical field

[0001] The present invention relates to the application of the perilla leaf extract, in particular to the application of the perilla leaf extract in the preparation of medicines for preventing and treating acute lung injury. Background technique

[0002] Acute lung injury (ALI) refers to patients suffering from infection, inhalation injury (toxic gas, acid reflux, drowning, etc.), mechanical injury, iatrogenic lung injury caused by radiotherapy and chemotherapy, severe pancreatitis, sepsis, etc. In the process of non-cardiac diseases such as hyperemia or severe non-thoracic trauma, the injury of pulmonary capillary endothelial cells and alveolar epithelial cells causes diffuse pulmonary interstitial and alveolar edema, resulting in acute hypoxic respiratory insufficiency or respiratory failure, which is extremely serious harm to human health. Although the pathogenesis of ALI has not been fully elucidated, studies have confirmed that the main pathogenesis of ...

Examples

Embodiment 1

[0029] Preparation of perilla leaf extract

[0030] Take 5000 g of perilla leaves and mix them with 40000 mL of ethanol aqueous solution with a volume concentration of 70%, heat and reflux for extraction for 2 hours, extract twice in total, filter, combine the filtrates, concentrate to extract, and vacuum dry to obtain perilla leaf extract.

Embodiment 2

[0032] Preparation of perilla leaf extract

[0033] Take 5000g of perilla leaves and mix them with 30000mL of 80% ethanol aqueous solution, heat and reflux for extraction for 1.5 hours, extract 3 times in total, filter, combine the filtrates, concentrate to extract, and vacuum dry to obtain perilla leaf extract.

Embodiment 3

[0035] Preparation of perilla leaf extract

[0036] Take 5000g of perilla leaves and mix them with 50000mL of 60% ethanol aqueous solution, heat and reflux for extraction for 2.5 hours, extract twice in total, filter, combine the filtrates, concentrate to extract, and vacuum dry to obtain perilla leaf extract.

technical field

[0001] The present invention relates to the application of the perilla leaf extract, in particular to the application of the perilla leaf extract in the preparation of medicines for preventing and treating acute lung injury. Background technique

[0002] Acute lung injury (ALI) refers to patients suffering from infection, inhalation injury (toxic gas, acid reflux, drowning, etc.), mechanical injury, iatrogenic lung injury caused by radiotherapy and chemotherapy, severe pancreatitis, sepsis, etc. In the process of non-cardiac diseases such as hyperemia or severe non-thoracic trauma, the injury of pulmonary capillary endothelial cells and alveolar epithelial cells causes diffuse pulmonary interstitial and alveolar edema, resulting in acute hypoxic respiratory insufficiency or respiratory failure, which is extremely serious harm to human health. Although the pathogenesis of ALI has not been fully elucidated, studies have confirmed that the main pathogenesis of ...

Examples

Embodiment 1

[0029] Preparation of perilla leaf extract

[0030] Take 5000 g of perilla leaves and mix them with 40000 mL of ethanol aqueous solution with a volume concentration of 70%, heat and reflux for extraction for 2 hours, extract twice in total, filter, combine the filtrates, concentrate to extract, and vacuum dry to obtain perilla leaf extract.

Embodiment 2

[0032] Preparation of perilla leaf extract

[0033] Take 5000g of perilla leaves and mix them with 30000mL of 80% ethanol aqueous solution, heat and reflux for extraction for 1.5 hours, extract 3 times in total, filter, combine the filtrates, concentrate to extract, and vacuum dry to obtain perilla leaf extract.

Embodiment 3

[0035] Preparation of perilla leaf extract

[0036] Take 5000g of perilla leaves and mix them with 50000mL of 60% ethanol aqueous solution, heat and reflux for extraction for 2.5 hours, extract twice in total, filter, combine the filtrates, concentrate to extract, and vacuum dry to obtain perilla leaf extract.

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