Apparatus and method for plasma activation of liquids

Abstract

The invention relates to an apparatus and a method for plasma activation of a liquid. By means of the invention, an apparatus (10) for producing a plasma-activated liquid (F) having defined properties is provided. The apparatus (10) comprises a plasma application device (25) provided with a plasma applicator (29), wherein in the plasma application device (25) the liquid (F) is brought into contact with a gas plasma (30). A sensor device (36) is used to analyze the composition of the plasma-treated liquid (F) at least according to the species produced by the plasma treatment. Based on the concentration of one or more species detected by the sensor device (36), the treatment parameters of the liquid (F) in the plasma application device (25) can be adjusted or modified. Thereby, a plasma-treated liquid (F) having defined properties for the treatment of a patient is provided.

Description

Technical Field

[0001] The present invention relates to apparatus and methods for plasma activation of liquids for application to a patient. Background Art

[0002] Due to the effect of plasma on a liquid such as a NaCl solution, a Ringer's lactate solution or another solution, the liquid can be transferred under plasma activation conditions. The liquid then includes reactive species such as free radicals with increased redox potential, and substances such as peroxides, peroxynitrites, nitrates, nitrites, nitrogen oxides (oxides or reactive species centered on nitrogen), which reactive species include medical effects. Such activated liquids can be used for indirect plasma treatment (plasma treatment). The effect on the tissue to be treated can be a disinfecting effect. The liquid can inactivate microorganisms and bacterial organisms. In addition, the treatment can have different effects on pathogens and healthy cells based on the plasma-activated liquid. The different effects are based on the species contained in the plasma-activated liquid.

[0003] In order to produce a plasma-activated liquid, WO 2015 / 123720 A1 proposes applying a plasma to the gel surface. In particular, reference is made to non-thermal so-called cold plasmas, which comprise a highly reactive mixture of oxygen, nitrogen and hydrogen radicals, ions, electrons, photons and ultraviolet radiation.

[0004] US 2012 / 0111721 A1 and WO 2007 / 117634 A2 propose an apparatus for plasma treatment of liquids. The plasma treatment is performed in a rotationally symmetrical container, on the walls of which a thin liquid film flows. Thus, a discharge occurs between two graphite electrodes, and the radiation generated thereby affects the liquid.

[0005] EP 1 702 678 A1 proposes treating a liquid film with electron radiation in a vacuum vessel. Alternatively, in this document, the treatment of the liquid film with a UV source is considered, which is provided instead of or in addition to the electron radiation source.

[0006] EP 2 937 103 A1 proposes to activate an active medium, such as a wound pad, by means of plasma. For this purpose, the wound pad can include a plasma-activatable gel, a plasma-activatable liquid or a carrier layer impregnated with a plasma-activatable fluid. By means of a plasma treatment of the active medium, active substances are generated or released therein. Water-based liquids, saline solutions and gels obtained therefrom are considered active media. For the plasma treatment, a plasma generator is provided, which, for example, generates a cold plasma at atmospheric pressure. The plasma is applied to the active medium in a two-dimensional manner. After activation, the wound pad can be attached to the patient.

[0007] US 2019 / 0110933 A1 and WO 2017 / 167748 A1 propose wound treatment by combining plasma and vacuum application. For this purpose, a vacuum treatment device is connected to an antimicrobial and healing atmospheric plasma source, wherein a sensor device can be provided for detecting healing. For this purpose, the sensor system can detect at least one physical parameter on the patient's body surface. Based on the detected parameter, the condition of the wound is assessed. The detected parameter can in particular be temperature, pressure, humidity and / or pH value.

[0008] WO 2017 / 074979 A1 discloses the problem of deterioration of the medical effect of plasma-activated liquids during longer storage periods. In order to maintain such plasma-activated liquids in a storable state for a long period of time, it is proposed to use the liquids for plasma activation, reduce their cysteine, methionine, phenylalanine and phenol red contents, and add three-nitro-L-tyrosine thereto.

[0009] US 2014 / 0322096 A1 and WO 2014 / 055812 A1 describe a disinfection system, which is particularly used for disinfecting the hands of surgeons. For this purpose, a reaction vessel is provided, in which a barrier discharge occurs between two insulated electrodes. Atomized washing liquid is conveyed through the plasma thus generated, which is collected on the bottom in the vessel and can subsequently be distributed via a nozzle for disinfecting the hands.

[0010] US 2015 / 0306258 A1 describes a method for sterilizing corneal tissue prior to its transplantation. To this end, the tissue is subjected to a plasma-activated fluid. For the plasma activation, the fluid is delivered in an atomized state before being applied to the cornea as a spray cone by a cold plasma discharge.

[0011] WO 2017 / 091534 A1 describes a method and system for killing or inactivating spores by applying a liquid to a surface to be sterilized, wherein the liquid comprises an additive to maintain plasma activation for at least a period of 30 seconds. The additive may be, for example, a nitrite, a biologically active oil, an acid, a transition metal or an enzyme.

[0012] In contrast, WO 2014 / 145570 A1 and WO 2014 / 152256 A1 propose applying plasma directly to the water surface, thereby generating free radicals in the water. The plasma-activated water can be used for surface disinfection.

[0013] WO 2017 / 083323 A1 also addresses the generation of plasma-activated liquids. For this purpose, a device is provided in which an aerosol consisting of gas and liquid is passed along one or more plasma generators in order to activate the gas and / or liquid. In order to separate the gas and liquid after the plasma treatment, a precipitation device is provided. The liquid can be used for disinfection purposes. A barrier discharge is used for the generation of the plasma.

[0014] WO 2018 / 089577 A1 relates to a system and a method for plasma activation of liquids, wherein the activation is to reach particularly high concentrations and wherein a large amount of liquid is to be activated. For this purpose, a device is provided which transfers the liquid in a thin layer, wherein a plasma is generated near the thin liquid layer.

[0015] US 2019 / 0279849 A1 discloses plasma activation of a liquid by discharge, wherein an electric current is conducted from an electrode to the liquid. A distance of 6 mm to 10 mm is proposed. In addition, a light receiving device is provided in order to detect the typical lines of the generated free radicals or ions in the context of photoemission spectroscopy.

[0016] CN 109121278 A also operates under the direct influence of the discharge on the liquid and the current passing through it. The discharge can also be an electrical barrier discharge.

[0017] WO 2017 / 192618 A1 describes an apparatus and a method for producing a plasma-activated aqueous chemotherapeutic agent. For this purpose, a discharge vessel is provided, in which at least one hollow needle-shaped electrode is arranged, wherein the vessel is lined on the inside in an electrically insulating manner. The electrode is attached to a rotating hollow shaft into which air is conveyed. A barrier discharge is generated between the electrode and the vessel wall. The liquid conveyed into the vessel is brought into close contact with the barrier discharge and is discharged at the bottom end of the vessel in an activated state.

[0018] By means of the cited method, plasma-activated aqueous liquids can be produced. It is also known that such activated liquids can be stored at least for a limited period. The activated liquids thus act over a broad spectrum, wherein their efficacy varies over time. This may constitute an uncertainty factor for the application of plasma-activated liquids. Summary of the invention

[0019] Starting from this, it is an object of the present invention to improve the reproducibility of the treatment success during medical applications of plasma-activated liquids.

[0020] The device of the invention for supplying a plasma-activated liquid to a medical device comprises a plasma generator and a plasma application device, by means of which the plasma generated by the plasma generator is brought into contact with the liquid. The liquid can be discharged continuously or in portions via the outlet of the plasma application device and can be supplied to the device. Thus, the liquid can be discharged directly to the device or can be temporarily stored in a storage container for a period of time.

[0021] According to the present invention, a sensor device is provided for detecting at least one chemical or physical parameter of the liquid during and / or after plasma exposure. The parameter detected by the sensor device is used by a control device to control the characteristics of the plasma-activated liquid discharged to the apparatus. The control device comprises an input connected to the sensor device. On the output side, the control device can be connected to a plasma generator, for example, in order to influence the parameters of the plasma discharge. Additionally or alternatively, the control device can be connected to a plasma application device, a pump, a valve or a similar control element, in order to influence the parameters of the plasma treatment. In this way, for example, the residence time of the liquid in or at the plasma can be controlled. If the liquid is contacted with the plasma as a film or as a droplet, the control device can affect the flow rate of the liquid, the droplet size of the liquid, the layer thickness of the liquid, etc. Additionally or alternatively, the control device can be connected to a control element of a storage container, such as a valve or a pump, in order to influence the residence time of the activated liquid in the storage container.

[0022] Preferably, the plasma generator comprises a gas channel and at least one electrode, which is in contact with the gas from the gas channel. The electrode can be an insulated electrode so as to supply a barrier discharge. It can be an electrode with a conductive surface so as to allow electrons to be directly transferred from the electrode to the plasma. The gas channel can be applied with a gas, in particular an inert gas, such as argon. In this way, ionization of the gas can occur at the electrode, and thus a plasma, in particular a plasma jet in contact with a liquid, can be generated. The liquid can be in electrical contact with the electrode. This is preferably a non-insulated electrode. In this case, it includes a conductive surface so that it is possible for electrons to transfer from the liquid to the electrode and from the electrode to the liquid. Preferably, liquid activation by plasma occurs due to the application of the plasma jet on the liquid. Thus, the liquid can be provided as a compact body with, for example, a horizontal liquid surface. The plasma jet can also be introduced into the liquid so that part of the plasma rises with the bubbles in the liquid. In addition, the atomized liquid can be introduced into the argon plasma jet. However, instead of the argon plasma jet, other types of plasma, in particular air plasma, can also be used. The plasma may be a cold plasma, or it may be a plasma whose gas temperature is "warm", ie, whose gas temperature is higher than human body temperature.

[0023] Plasma generators having uninsulated electrodes that allow electric current to pass through the liquid are particularly suitable for plasma activation of liquids.

[0024] Due to the plasma treatment, species are generated in the liquid, i.e. chemical compounds with different life spans and reactivity, which are represented as plasma-generated substances as a whole. The substances generated by this plasma can be hydronium ions, hydroxide ions, hydrogen peroxide and / or nitrite ions and / or nitrate ions and / or peroxynitrite and / or singlet oxygen and / or ozone and / or oxygen and / or superoxide radical ions and / or hydroxyl radicals and / or hydroperoxyl radicals and / or nitrogen oxides, such as nitric oxide and nitrogen dioxide. The sensor device provided for detecting such species can be a sensor device, i.e., it is suitable for optical spectroscopy for ultraviolet light, visible light or infrared light, such as absorption spectroscopy. Additionally or alternatively, the sensor device can be a device suitable for detecting phosphorescence, particularly near-infrared phosphorescence. Additionally or alternatively, the sensor device can be a device for performing optical emission spectroscopy for UV light, visible light and / or near-infrared light. Additionally or alternatively, the sensor device can be an electron spin resonance spectroscopy device. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] Further details of advantageous embodiments of the invention are the subject of the description or the drawings. The drawings show:

[0026] Figure 1 is a block diagram for illustrating the structure and functional elements of the device of the present invention for supplying a plasma-activated liquid to a medical component,

[0027] Figure 2 It is a plasma application device for producing plasma-activated liquids. DETAILED DESCRIPTION

[0028] Figure 1 A device 10 for supplying a plasma-activated liquid to a medical device 11 is shown, with which device 10 at least one different treatment method can be performed. Figure 1 The functional blocks in the figure illustrate the treatment method, wherein block 13 represents sub-tissue injection of a plasma-activated liquid. Block 14 represents alternating treatment of tissue with plasma, such as argon plasma, and / or with RF current and plasma-activated liquid. Block 15 represents wetting or spraying of tissue with plasma-activated liquid.

[0029] The instrument 11 is intended to mean any instrument with which at least one of the methods illustrated in blocks 13 - 15 can be performed, as well as other instruments for variously applying plasma-activated liquids to a patient or biological tissue.

[0030] The device 10 comprises a treatment container 16 in which a liquid is to be treated with plasma, for example a sodium chloride solution, a Ringer's solution, a Ringer's lactate solution or another liquid that can be applied to a patient. The liquid originates from a storage container 17, which is connected to the treatment container 16 via a controllable pump 18. The pump 18 is used to pump the liquid from the storage container 17 into the treatment container 16 under the control of a control device 19, as shown by arrows 20, 21. In addition, the pump 18 can be configured, at least as an option, to pump the liquid from the treatment container 16 back into the storage container 17, as shown by arrows 22, 23. The supply direction of the operation of the pump 18 and the supply rate as required are set by the control device 19, as shown by arrow 24.

[0031] The processing container 16 may be a container in which the liquid F to be processed is provided as a compact liquid body having a substantially horizontal surface, such as Figure 2. In addition, any other container can also be used as the processing container 16, in which the liquid can be brought into contact with the plasma. For example, such containers are: a pouring container, in which a droplet curtain can be poured through the plasma, or a liquid layer can be poured along the plasma; a container with a sprayer, which introduces the liquid into the plasma as a spray; a rotating device, which brings the liquid in the form of a thin film into contact with the plasma, etc. The processing container 16 and the plasma 30 ( Figure 2 ) together form a plasma application device 25.

[0032] to this end, Figure 1 In the functional blocks 26-28 surrounded by dotted lines, different mixing devices are illustrated, at least one of which is preferably provided and is used to evenly distribute the reactive species generated in the processing container. A convection device 26 can be used for this purpose, which generates convection by applying heat or cold to the liquid. As an alternative, a stirring device 27 can be provided, which is used to move the liquid F in the processing container 16. Functional block 28 illustrates a gas cyclone device so that the liquid in the processing container is in close contact with the plasma 30. Each device represented by functional blocks 26, 27, 28 can be arranged in or at the processing container 16 alone or in combination with one or more of the devices shown.

[0033] As from Figure 2 As is evident, a plasma applicator 29 is assigned to the process container 16, which is configured for generating a plasma 30. For example, the plasma applicator 29 can be an argon plasma applicator. It comprises a gas supply channel 31, via which an inert gas, such as nitrogen, a rare gas, such as argon or helium, is supplied, or another gas for generating a plasma, such as a reactive gas, such as an oxygen-containing gas, is provided. The gas channel 31 is connected to a gas source 32. It can be configured in a controllable manner, such as Figure 1 and can be connected to the control device 19 so as to be controlled according to the time point of gas discharge and / or according to the gas flow rate.

[0034] The plasma applicator further comprises an electrode 33 which is constructed in a non-insulated manner, ie an electrode 33 having an electrically conductive surface which is in contact with the gas flow of the gas supply channel 31 or is surrounded thereby.

[0035] The electrode is connected to one pole of a plasma generator 34, the other pole of which is connected, for example, to an electrode 35 surrounded by a flow of liquid F. The plasma generator is preferably an RF generator, which is configured to provide a radio frequency voltage and a radio frequency current. The generator is preferably controllable according to the supplied voltage and / or the supplied power and / or the amount of current and / or according to the waveform, the modulation of the duty cycle, the crest factor or other parameters. To this end, the plasma generator 34 can be connected to the control device 19 and can be controlled by it, such as Figure 1 as shown in .

[0036] The device 10 further comprises a sensor device 36 which is configured and arranged to perform an analysis of species formed in the treated liquid F. These species are substances formed by the plasma treatment of the liquid F in the broadest sense, and also include ions, free radicals, fractions of molecules, etc. The sensor device 36 can be arranged outside the treatment container 16, such as Figure 1 and can be supplied with liquid F from the treatment container 16 , for example via circulation 37 .

[0037] Figure 2 Schematically illustrated in FIG. 1 is a sensor device 36 for optical absorption spectroscopy. To this end, the sensor device 36 comprises a light emitting device 38 and a light receiving device 39. The light emitting device 38 is configured, for example, to emit ultraviolet light, visible light and / or infrared light having a known spectral component into the liquid F. The light receiving device 39 is preferably configured to detect the spectral component of the ultraviolet light, visible light and / or infrared light that has passed through the liquid F. The control device 19 is configured to determine the presence and concentration of the selected species based on the difference between the spectra of the light emitted by the light emitting device 38 and the light received by the light receiving device 39.

[0038] Instead of being configured as a sensor device 36 for optical absorption spectroscopy, any other sensor device configured to detect the presence and / or concentration of one or more species in a liquid may also be provided. Such a sensor device may be an emission spectroscopy device for ultraviolet light, visible light and / or infrared light. The sensor device may also be a phosphorescence detection device for ultraviolet light, visible light and / or infrared light, in particular for near infrared light. The sensor device 36 may also be a device for pH measurement, in particular a single-rod measuring cell. The sensor device 36 may include one or more of the above-mentioned sensor devices.

[0039] The control device 19 may control the plasma generator 34 in order to control the concentration and / or composition of different species in the liquid F. For example, the control device 19 may control the current and / or voltage supplied by the plasma generator 34 in terms of power, amount, waveform, crest factor, frequency, modulation, etc. in order to control the plasma and thereby control the generation of the species.

[0040] The treatment container 16 can be connected directly to the device 11 via a pump 40 in order to supply the plasma-activated liquid to the device 11. As an option, a storage container 41 can be provided between the pump 40 and the device 11, in which the plasma-activated liquid can be stored for a predetermined or selectable period of time.

[0041] In addition to or as an alternative to the cycle 37, the sensor device 36 can be connected to the storage container 41. Similarly, the storage container 41 can be connected to a separate sensor device, which in turn is connected to the control device 19. By controlling the pump 40 and / or a pump (not further illustrated) arranged between the storage container 41 and the device 11, the control device 19 can define the storage duration of the plasma-treated liquid F. Since the concentration of the species produced in the plasma-treated liquid decreases at different rates after the plasma treatment of the liquid F, the control device 19 can discharge the plasma-treated liquid F by setting a defined storage duration as required under the control of the sensor device 36, wherein, for example, species with a short lifetime have largely disappeared, whereas species with a long lifetime are contained in a higher concentration. On the other hand, if the treatment request mainly includes species with a short lifetime, it can be determined by means of the sensor device 36 whether these species have been produced in a sufficient concentration in order to immediately supply them to the device 11. For this purpose, it can be provided that the liquid for post-activation is supplied from the storage container 41 to the treatment container 16 as required. This is in Figure 1 This is indicated by double arrows 42 , 43 .

[0042] The apparatus 10 and device 11 described thus far operate as follows:

[0043] First, through the filling neck 44 ( Figure 1 ) The storage container 17 is filled with the liquid to be activated, for example a sodium chloride solution. The control device 19 now activates the pump 18 and supplies the liquid F in the treatment container 16, for example by filling the treatment container 16 with the liquid F. In addition, the control device 19 activates the plasma generator 34 and, if necessary, the gas source 32, so that the plasma applicator 29 now generates a plasma 30 ( Figure 2). The sensor device 36 is operated continuously or at discrete intervals in order to detect the quality of the liquid F, i.e. its plasma activation. The quality of the plasma activation is thus defined in particular by the concentration of selected species, for example by the content of hydronium ions, hydroxide ions, hydrogen peroxide, nitrite, nitrate, peroxynitrite, singlet oxygen, ozone, hydroperoxide, oxygen, superoxide radical ions, hydroxyl radicals and / or hydroperoxyl radicals. In order to detect such species, the sensor device 36 is designed as a so-called pH single-rod measuring cell, a spectrometer for emitting light (IR, visible and / or UV), an absorption spectrometer (e.g. Figure 2 ), for example, a phosphorescence sensor or an electron spin resonance spectrometer for measuring the radiation of singlet oxygen at a wavelength of 1275 nm. The sensor device 36 can also include a plurality of the measuring devices shown.

[0044] Based on the concentration of the selected species determined by the sensor device, the control device 19 can set, extend or reduce the duration of the plasma treatment of the liquid, can adjust the parameters of the current or voltage supplied by the plasma generator 34, and / or can influence the gas flow from the gas source 32. Additionally or alternatively, the control device 19 can set or limit the storage duration of the plasma-treated liquid in the storage container 41, and / or can control one or more of the devices 26-28.

[0045] The control device 19 may be configured to influence the quality of the liquid F according to one or more of the following dependencies:

[0046] - The effect of the plasma intensity, ie the electrical power or other parameters converted in the plasma, depends on the desired pH value. For higher powers, lower pH values ​​are achieved.

[0047] - Define the duration of application of the plasma to the liquid, which depends on the desired pH value. For longer application durations, lower pH values ​​are achieved.

[0048] - Defining the intensity of the plasma effect, ie the electrical power or other parameters converted in the plasma, which depends on the desired ratio of hydrogen to nitrate.

[0049] - The choice of the liquid to be treated, which depends on the desired ratio of hydrogen to nitrate. Liquids available for selection are, for example, NaCl solution and phosphate-buffered NaCl solution.

[0050] The control device 19 may use the chemical and / or physical parameters of the treated liquid F detected by the sensor device 36 in order to control the operation of the plasma application device 25 or the plasma generator 34 in order to achieve a desired quality of the liquid F, i.e. a desired composition of the obtained species. During the control of the plasma generator, at least one parameter of the current and / or voltage supplied by it is influenced.

[0051] By means of the present invention, a device 10 for producing a plasma-activated liquid F having defined properties is provided. The device 10 comprises a plasma application device 25 provided with a plasma applicator 29, wherein in the plasma application device 25, the liquid F is brought into contact with a gas plasma 30. A sensor device 36 is used to analyze the composition of the plasma-treated liquid F at least in terms of species generated by the plasma treatment. Based on the concentration of one or more species detected by the sensor device 36, the treatment parameters of the liquid F in the plasma application device 25 can be adjusted or modified. Thereby, a plasma-treated liquid F having defined properties for the treatment of a patient is provided.

[0052] List of reference numerals:

[0053] 10. Apparatus for producing a plasma activated liquid

[0054] 11. Instruments

[0055] 12-15 Functional box, which is used to represent the treatment of liquid using plasma activation

[0056] 16. Processing Container

[0057] 17 Storage Container

[0058] 18 Pumps

[0059] 19 Control Device

[0060] 20, 21 Arrows indicating the pumping direction of pump 18

[0061] 22, 23 Arrows for optional pumping directions of pump 18

[0062] 24 Arrow for controlling pump 18

[0063] 25. Plasma application device

[0064] 26 Functional Frame Convector

[0065] 27 Functional frame stirring device

[0066] 28 Functional Frame Gas Cyclone Device

[0067] 29 Plasma Applicator

[0068] 30 Plasma

[0069] 31 Gas supply channel

[0070] 32 Gas Source

[0071] 33 Electrode

[0072] 34 Plasma Generator

[0073] 35 Electrode

[0074] 36 Sensor Device

[0075] 37 loops

[0076] 38 Light emitting device

[0077] 39 Light receiving device

[0078] 40 Pumps

[0079] 41 Storage Container

[0080] 42, 43 double arrow

[0081] 44 Fill the neck.

Claims

1. A device (10) for supplying a plasma-activated liquid to a medical device (11), having a plasma generator (34) for supplying plasma (30), having a plasma application device (25) in which a liquid (F) can come into contact with the plasma (30), and having an outlet for draining the liquid from the plasma application device (25) and supplying the liquid to the apparatus (11), having a sensor device (36) for detecting at least one chemical or physical parameter of the liquid (F) during and / or after plasma exposure in the plasma application device (25), in, The plasma generator (34) can be controlled according to the crest factor or waveform of the supplied current or the supplied voltage, The device comprises a storage container (41), which can be connected to the device (11), and Therein, the sensor device (36) and / or the control device (19) is connected to at least one control element in order to control the residence time of the liquid (F) in the storage container (41).

2. The device according to claim 1, characterized in that The plasma application device (25) comprises: a plasma applicator (29) having a gas channel (31) and at least one first electrode (33), the at least one first electrode (33) being in contact with the gas from the gas channel; and a second electrode (35) being in electrical contact with the liquid, the first electrode and the second electrode (33, 35) both being connected to the plasma generator (34).

3. The device according to claim 1 or 2, characterized in that: The plasma generator (34) can be controlled according to the supplied voltage, current and power.

4. The device according to claim 3, characterized in that The sensor device (36) and / or the control device (19) are connected to the plasma generator (34) in order to control it in dependence on the detected parameters.

5. The device according to claim 2, characterized in that The gas channel (31) is connected to a gas source (32) which can be controlled in terms of gas flow.

6. The device according to claim 5, characterized in that The sensor device (36) and / or the control device (19) are connected to the gas source (32) in order to control its gas flow in dependence on the detected parameter.

7. The device according to claim 1 or 2, characterized in that: The sensor device (36) is configured to detect temperature and / or conductivity and / or acidity and / or chemical composition and / or concentration of a specific chemical compound.

8. The device according to claim 1 or 2, characterized in that: The sensor device (36) is configured to detect the concentration of a plasma-generated substance in the plasma-activated liquid, wherein the plasma-generated substance is in the form of hydronium ions (H3O) + and / or hydroxide ions OH - and / or hydrogen peroxide H2O2 and / or nitrite ions NO2 - and / or nitrate ions NO3 - and / or hydroxyl radicals·OH.

9. The device according to claim 1 or 2, characterized in that: The sensor device (36) is configured to detect the concentration of a plasma-generated substance in the plasma-activated liquid (F) by spectroscopy.

10. The device according to claim 9, characterized in that Such spectroscopy includes absorption spectroscopy of electromagnetic radiation.

11. The device according to claim 10, characterized in that The electromagnetic radiation is light.

12. The device according to claim 11, characterized in that The light is visible light.

13. The device according to claim 1 or 2, characterized in that The sensor device (36) is configured to detect the concentration of a plasma-generated substance in the plasma-activated liquid (F), wherein the plasma-generated substance is in the form of singlet oxygen. 1 O2 and / or ozone O3 and / or oxygen O2 and / or superoxide radical ion O2 - and / or hydroperoxide radical HOO and / or peroxynitrite ion ONOO - and / or nitrogen oxides.

14. The device according to claim 13, characterized in that The nitrogen oxides are nitrogen monoxide NO or nitrogen dioxide NO2.

15. The device according to claim 1 or 2, characterized in that The sensor device (36) is configured to detect the concentration of a plasma-generated substance in the plasma-activated liquid (F) by means of phosphorescence or electron spin resonance spectroscopy.

16. A method for providing a plasma activated treatment liquid, wherein: The plasma (30) is provided by a plasma generator (34), The liquid (F) comes into contact with the plasma (30) in the plasma application device (25) and is supplied to the device (11), During and / or after the plasma exposure in the plasma application device (25), at least one chemical or physical parameter of the liquid (F) is detected by means of a sensor device (36), wherein the operation of the plasma generator (34) and / or the residence time of the plasma-treated liquid in the storage container (41) is controlled in order to influence the parameter, and The plasma generator (34) can be controlled according to the crest factor or waveform of the supplied current or the supplied voltage. wherein the storage container (41) is connectable to the device (11), and Therein, the sensor device (36) and / or the control device (19) is connected to at least one control element in order to control the residence time of the liquid (F) in the storage container (41).

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