Traditional Chinese medicine atomizing liquid for treating rhinitis, preparation method and application thereof

Abstract

The application discloses a traditional Chinese medicine atomizing liquid for treating rhinitis and a preparation method and application thereof, and belongs to the field of traditional Chinese medicine, wherein the traditional Chinese medicine atomizing liquid comprises the following raw materials in parts by weight: mace 20-25 parts, clove 45-50 parts, red ginseng 15-20 parts, cardamom 20-25 parts, cardamom 20-25 parts, kadsura 20-25 parts and chuanmuhuang 20-25 parts. The traditional Chinese medicine atomizing liquid can be applied to different types of rhinitis such as acute rhinitis, chronic rhinitis, allergic rhinitis and sinusitis, has obvious relieving effects on symptoms such as nasal congestion, much rhinorrhea, olfactory decline, headache, memory decline and easy tiredness, and the like. In addition, the traditional Chinese medicine atomizing liquid has positive prevention and treatment effects on early rhinitis, and has relieving functions on mature rhinitis, has the characteristics of good curative effect, convenient carrying, less pain, no side effects and the like.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine, specifically to a traditional Chinese medicine nebulizer for treating rhinitis, its preparation method, and its application. Background Technology

[0002] Rhinitis is an inflammation of the nasal mucosa caused by viruses, bacteria, allergens, various physical and chemical factors, and certain systemic diseases. Rhinitis is commonly categorized in Western medicine as acute rhinitis, chronic rhinitis, and allergic rhinitis. Different types of rhinitis share similar symptoms, such as nasal congestion, runny nose, decreased sense of smell, headache, memory loss, and fatigue. From a Traditional Chinese Medicine (TCM) perspective, external causes are often attributed to exposure to wind-cold or wind-heat pathogens, while internal causes are often related to dysfunction of the internal organs, primarily the lungs, stomach, liver, gallbladder, and spleen, whether due to excess or deficiency. The diagnosis of rhinitis primarily distinguishes between excess and deficiency patterns. Generally, sudden onset, early stages, and robust constitution often indicate an excess pattern; chronic illness, weakness, lingering symptoms, and fluctuating severity often indicate a mixture of excess and deficiency, with pure deficiency being rare. Excess patterns should differentiate the predominance of wind, dampness, and heat; deficiency patterns should consider the differences between qi deficiency, yin deficiency, and yang deficiency, and also differentiate their relationship with the lungs, gallbladder, spleen (stomach), and kidneys. This disease is often lingering and difficult to cure. One reason is that the body's vital energy is deficient while the pathogenic factors linger. Another reason is that the external pathogenic factors have been present for a long time, turning into fire that burns the body fluids and causes phlegm to obstruct the nasal passages.

[0003] Currently, the treatment for rhinitis mostly involves using nasal sprays supplemented with Western medicine to reduce inflammation. This can temporarily relieve rhinitis symptoms, but the efficacy is poor, and there are many types of medications available, making preparation cumbersome. Meanwhile, there are reports of using traditional Chinese medicine combinations to treat specific rhinitis types such as allergic rhinitis or chronic rhinitis, but there are no reports of traditional Chinese medicine nebulizer solutions that can be applied to multiple rhinitis types simultaneously. Summary of the Invention

[0004] To address the aforementioned shortcomings, the purpose of this invention is to provide a traditional Chinese medicine nebulizer solution for treating rhinitis, its preparation method, and its application. This nebulizer solution is applicable to different types of rhinitis, such as acute rhinitis, chronic rhinitis, allergic rhinitis, and sinusitis, and significantly relieves symptoms such as nasal congestion, runny nose, decreased sense of smell, headache, memory loss, and fatigue. Furthermore, this nebulizer solution has a positive preventive and therapeutic effect on early-stage rhinitis and also provides relief for mature rhinitis. It is characterized by good efficacy, convenient portability, minimal discomfort, and no side effects. This invention is the first in the industry to propose a treatment concept of "prevention combined with resistance, early intervention." It relieves itching and clears nasal congestion in different types of rhinitis, gradually eliminating symptoms, improving breathing, and reducing the likelihood of recurrence.

[0005] To achieve the above objectives, the present invention adopts the following technical solution:

[0006] This invention provides a traditional Chinese medicine nebulizer for treating rhinitis, comprising the following raw materials in parts by weight: 20-25 parts nutmeg, 45-50 parts cloves, 15-20 parts rhodiola rosea, 20-25 parts cardamom, 20-25 parts amomum tsao-ko, 20-25 parts chebula, and 20-25 parts costus root.

[0007] Furthermore, the above-mentioned herbal nebulizer solution for treating rhinitis includes the following ingredients in parts by weight: 20 parts nutmeg, 45 parts cloves, 15 parts rhodiola rosea, 20 parts cardamom, 20 parts amomum tsao-ko, 20 parts chebula, and 20 parts costus root.

[0008] Furthermore, the above-mentioned herbal nebulizer solution for treating rhinitis includes the following ingredients in parts by weight: 25 parts nutmeg, 50 parts cloves, 20 parts rhodiola rosea, 25 parts cardamom, 25 parts amomum tsao-ko, 23 parts chebula, and 22 parts costus root.

[0009] Furthermore, the above-mentioned herbal nebulizer solution for treating rhinitis includes the following ingredients in parts by weight: 22 parts nutmeg, 48 parts cloves, 17 parts rhodiola rosea, 23 parts cardamom, 22 parts amomum tsao-ko, 25 parts chebula, and 25 parts costus root.

[0010] The present invention also provides a method for preparing the above-mentioned traditional Chinese medicine nebulizer for treating rhinitis, comprising the following steps:

[0011] (1) Add the pulverized medicinal materials and extraction solvent into a container, heat to 50-95℃, stir until evenly mixed, keep warm and stir for 30-120 min, centrifuge, take the supernatant and filter to obtain the crude drug;

[0012] (2) Add solvent to the raw medicinal material obtained in step (1) to adjust the concentration of raw medicinal material in the liquid to 0.4-0.5 g / g of raw medicinal material, sterilize, and fill to obtain the product.

[0013] Furthermore, the extraction solvent includes water, ethanol, or propylene glycol; preferably propylene glycol.

[0014] Furthermore, when adjusting the concentration of raw medicinal materials in the liquid with a solvent, the mass ratio of raw medicinal materials to solvent in the liquid is 1:1 to 10, preferably 1:2 to 5, and most preferably 1:3 to 5.

[0015] Furthermore, the extraction temperature is preferably 70–90°C, and most preferably 80°C.

[0016] Furthermore, the extraction time is preferably 30–60 min.

[0017] The present invention also provides the application of the above-mentioned traditional Chinese medicine atomizing liquid for treating rhinitis in the preparation of electronic cigarettes.

[0018] Furthermore, in application, commercially available electronic cigarette devices are used to atomize the traditional Chinese medicine liquid, which is convenient to use.

[0019] An electronic cigarette uses the aforementioned traditional Chinese medicine atomizing liquid used to treat rhinitis as its e-cigarette liquid.

[0020] The efficacy of each ingredient in the herbal nebulizer solution for treating rhinitis provided by this invention is briefly described below:

[0021] Nutmeg: pungent in flavor and warm in nature. It enters the spleen, stomach, and large intestine meridians. It is mainly used for diarrhea due to deficiency; dysentery due to cold; abdominal distension and pain; poor appetite and vomiting; and indigestion. According to *Ben Cao Zheng Yi* (Correct Interpretation of Materia Medica): Nutmeg dispels cold and dries dampness, resolves stagnation and promotes qi circulation, and specifically regulates the spleen and stomach. It is quite similar to cardamom, so its pungent and warm effects are essentially the same, but its astringent taste is stronger, and it can also consolidate the large intestine to prevent prolapse. It is found in the Four Gods Pill.

[0022] Clove: pungent and warm. It enters the spleen, stomach, lung, and kidney meridians; it has the effect of clearing heat and drying dampness.

[0023] Rhodiola rosea: Also known as rose rhodiola, Saolomapur (Tibetan name); a perennial herb. It is cold in nature and sweet and astringent in taste. It enters the lung meridian. It has the effects of tonifying qi and clearing the lungs, benefiting intelligence and nourishing the heart, astringing and stopping bleeding, and dispersing blood stasis and reducing swelling. It is mainly used to treat qi deficiency and weakness, post-illness aversion to cold, shortness of breath and fatigue, lung heat cough, hemoptysis, leukorrhea and diarrhea, and traumatic injuries.

[0024] Cardamom: pungent in flavor, warm in nature, and enters the lung, spleen, and stomach meridians. Functions: resolves dampness and promotes qi circulation, warms the middle jiao and stops vomiting, invigorates the stomach and aids digestion. Indications: used for dampness obstructing the middle jiao, loss of appetite, early stages of damp-heat syndrome, chest tightness and lack of hunger, vomiting due to cold-dampness, chest and abdominal distension and pain, and indigestion.

[0025] Cardamom: It enters the spleen and stomach meridians and has the effects of drying dampness and dispelling cold, eliminating phlegm and stopping malaria, and promoting digestion.

[0026] Terminalia chebula: Bitter, sour, and astringent in taste, neutral in nature. It enters the lung and large intestine meridians. It is the dried, mature fruit of *Terminalia chebula* or *Terminalia velutipes*, plants in the Combretaceae family. It has astringent and lung-tonifying effects, reduces internal heat and soothes the throat. It is used for chronic diarrhea and dysentery, hematochezia and rectal prolapse, lung deficiency with wheezing and coughing, persistent cough, sore throat and hoarseness.

[0027] Sichuan costus root: pungent, bitter, and warm; enters the spleen, stomach, large intestine, and gallbladder meridians; can promote qi circulation and relieve pain.

[0028] In summary, the present invention has the following advantages:

[0029] 1. In this invention, the Chinese herbal nebulizer is selected based on the pharmacological guidance of regulating the functions of the five internal organs and six bowels and dispelling wind-cold and wind-heat pathogens. The raw materials are rationally combined to form a Chinese herbal nebulizer for treating rhinitis, giving full play to the dual effects of treating and regulating the body of the Chinese herbal compound preparation, and achieving the therapeutic effect of treating both the symptoms and the root cause of different types of rhinitis. Specifically, in this invention, nutmeg and cloves are the principal herbs, entering the spleen, stomach, lungs, and kidneys to invigorate the spleen and replenish qi, clear the lungs and nasal passages, and warm and tonify kidney yang, thus treating deficiencies in the lungs, spleen, and kidneys. Rhodiola rosea and cardamom are the assistant herbs, drying dampness and dispelling cold, replenishing qi and blood, and expelling wind-cold and wind-heat pathogens. They are beneficial in promoting blood circulation in the nasal mucosa, thereby relieving symptoms such as nasal congestion and runny nose, and playing a role in relieving itching and clearing the nasal passages. They also have the effects of invigorating the mind and nourishing the heart, helping to improve symptoms such as headaches, memory loss, and fatigue caused by rhinitis. Cardamom is the adjuvant herb. Terminalia chebula and costus root are the guiding herbs, harmonizing the effects of the other herbs. The combined use of these herbs in this invention achieves a good synergistic effect, with a reasonable combination, significant therapeutic effect, and no toxic side effects.

[0030] 2. The herbal nebulizer solution in this invention has a positive preventive and therapeutic effect on early-stage rhinitis, and also provides relief for mature rhinitis. It is characterized by good efficacy, convenient portability, minimal discomfort, and no side effects. This invention is the first in the industry to propose a treatment concept of "combining prevention and treatment, and early intervention." It relieves itching and clears the nasal passages for different types of rhinitis, gradually eliminating symptoms, improving breathing, and reducing the likelihood of recurrence.

[0031] 3. The herbal nebulizer liquid in this invention can be used with commercially available nebulizers for nebulization, and is easy to carry. Detailed Implementation

[0032] To make the objectives, technical solutions, and advantages of this invention clearer, the invention will be further described in detail below with reference to embodiments. It should be understood that the specific embodiments described herein are only for explaining the invention and are not intended to limit the invention; that is, the described embodiments are merely some embodiments of the invention, and not all embodiments.

[0033] Therefore, the following detailed description of the embodiments of the present invention is not intended to limit the scope of the claimed invention, but merely to illustrate selected embodiments of the invention. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without inventive effort are within the scope of protection of the present invention.

[0034] Example 1

[0035] This example provides a traditional Chinese medicine nebulizer solution for treating rhinitis, comprising the following ingredients in parts by weight: 20 parts nutmeg, 45 parts cloves, 15 parts rhodiola rosea, 20 parts cardamom, 20 parts amomum tsao-ko, 20 parts chebula, and 20 parts costus root.

[0036] The preparation method of the above-mentioned traditional Chinese medicine nebulizer solution for treating rhinitis includes the following steps:

[0037] (1) Add the pulverized medicinal materials and propylene glycol to a container, heat to 80°C, stir until evenly mixed, keep warm and stir for 60 min, centrifuge, take the supernatant and filter to obtain the raw medicine;

[0038] Add propylene glycol to the raw medicinal material obtained in step (1) to adjust the concentration of raw medicinal material in the liquid to 0.40 g / g of raw medicinal material, sterilize, and fill to obtain the final product.

[0039] Example 2

[0040] This example provides a traditional Chinese medicine nebulizer for treating rhinitis, comprising the following ingredients in parts by weight: 25 parts nutmeg, 50 parts cloves, 20 parts rhodiola rosea, 25 parts cardamom, 25 parts amomum tsao-ko, 23 parts chebula, and 22 parts costus root.

[0041] The preparation method of the herbal nebulizer used to treat rhinitis in this example is the same as in Example 1.

[0042] Example 3

[0043] This example provides a traditional Chinese medicine nebulizer solution for treating rhinitis, comprising the following ingredients in parts by weight: 22 parts nutmeg, 48 parts cloves, 17 parts rhodiola rosea, 23 parts cardamom, 22 parts amomum tsao-ko, 25 parts chebula, and 25 parts costus root.

[0044] The preparation method of the herbal nebulizer used to treat rhinitis in this example is the same as in Example 1.

[0045] Comparative Example 1

[0046] This example provides a traditional Chinese medicine nebulizer for treating rhinitis, comprising the following ingredients in parts by weight: 10 parts nutmeg, 45 parts cloves, 15 parts rhodiola rosea, 20 parts cardamom, 20 parts amomum tsao-ko, 20 parts chebula, and 20 parts costus root.

[0047] The preparation method of the herbal nebulizer used to treat rhinitis in this example is the same as in Example 1.

[0048] Comparative Example 2

[0049] This example provides a traditional Chinese medicine nebulizer solution for treating rhinitis, comprising the following raw materials in parts by weight: 25 parts nutmeg, 15 parts rhodiola rosea, 20 parts cardamom, 20 parts amomum tsao-ko, 20 parts chebula, and 20 parts costus root.

[0050] The preparation method of the herbal nebulizer used to treat rhinitis in this example is the same as in Example 1.

[0051] Comparative Example 3

[0052] This example provides a traditional Chinese medicine nebulizer solution for treating rhinitis, comprising the following ingredients in parts by weight: 20 parts nutmeg, 45 parts cloves, 15 parts rhodiola rosea, 20 parts sophora flavescens, 20 parts amomum tsao-ko, 20 parts chebula and 20 parts borneol.

[0053] The preparation method of the herbal nebulizer used to treat rhinitis in this example is the same as in Example 1.

[0054] Experimental Example

[0055] The efficacy of the herbal nebulizer solutions obtained in Examples 1-3 of this invention was observed in 200 patients with different types of rhinitis from 2010 to 2018 (including 72 cases of chronic rhinitis, of which 24 patients were treated with the products obtained in Examples 1-3; 68 cases of allergic rhinitis, of which 24, 22, and 22 patients were treated with the products obtained in Examples 1-3; and 60 cases of sinusitis, of which 20 patients were treated with the products obtained in Examples 1-3). Usage: Nebulizer treatment was performed. The dosage was 20g of the herbal preparation prepared from the raw materials, three times a day for 20 minutes each time. One month constituted one course of treatment, with three courses for consolidation. During treatment, attention should be paid to diet, avoiding raw, cold, greasy, and spicy foods. The clinical report is as follows:

[0056] 1. General Information

[0057] Of the 200 patients, the ages ranged from 16 to 68 years, the duration of illness ranged from 1 month to 8 years, and the average age was 38 years.

[0058] 2. Diagnostic criteria

[0059] The diagnostic criteria for "Clinical Research Guidelines for the Treatment of Sinusitis with New Traditional Chinese Medicine" in the "Guiding Principles for Clinical Research of New Traditional Chinese Medicine" were formulated.

[0060] Chronic rhinitis includes symptoms such as nasal itching, nasal congestion, increased secretions, nasal mucosal abscesses, olfactory dysfunction, dizziness, memory loss, and constipation. Some cases are characterized by nasal mucosal swelling and increased secretions, while others are characterized by localized or diffuse thickening and hyperplasia of the mucosa, submucosa, and even bone.

[0061] Allergic rhinitis is characterized by paroxysmal nasal itching, continuous sneezing, nasal congestion, and copious clear nasal discharge, accompanied by loss of smell, itchy eyes, and itchy throat. It has a rapid onset, with symptoms generally lasting from several minutes to tens of minutes. There is no sneezing or nasal congestion during the intervals. It can be complicated by urticaria, asthma, and other diseases. It is often caused by contact with allergens such as pollen, smoke, and chemical gases. Sometimes, changes in environmental temperature can also trigger it.

[0062] Sinusitis: Intermittent or persistent nasal congestion, copious sticky white nasal discharge; decreased sense of smell, pain in the forehead and maxillary sinus area, fever, aversion to wind, and sore throat. Red tongue with a thin white coating, floating pulse; congested and swollen turbinates, with sticky or purulent secretions visible in the middle nasal meatus.

[0063] 3. Criteria for Evaluating Therapeutic Effect

[0064] Recovery: Symptoms lessen within 7 days of medication and basically disappear within 30 days.

[0065] Significant effect: The main symptoms and signs are significantly improved within 30 days of medication.

[0066] Effective: The main symptoms and signs improve within 30 days of medication.

[0067] Ineffective: No improvement in main symptoms and signs within 30 days of medication.

[0068] 4. Results: Of the 200 patients, 157 (78.5%) were clinically cured, including 56 cases of chronic rhinitis, 56 cases of allergic rhinitis, and 45 cases of sinusitis; 39 (19.5%) showed significant improvement, including 14 cases of chronic rhinitis, 11 cases of allergic rhinitis, and 14 cases of sinusitis; and 4 (2%) were ineffective, including 2 cases of chronic rhinitis, 1 case of allergic rhinitis, and 1 case of sinusitis; the total effective rate was 98%.

[0069] In addition, the herbal nebulizer solutions obtained in Comparative Examples 1-3 were used to observe the efficacy in 90 patients with different types of rhinitis from 2010 to 2018 (including 12 cases of chronic rhinitis, of which 10 were treated with the products obtained in Comparative Examples 1-3 respectively). The treatment methods, courses of treatment, and treatment standards were the same as those for the products obtained in Examples 1-3 above. The results showed that in Comparative Example 1, 7 cases (23.3%) were clinically cured, including 2 cases of chronic rhinitis, 3 cases of allergic rhinitis, and 2 cases of sinusitis; 10 cases (33.3%) showed significant improvement, including 3 cases of chronic rhinitis, 3 cases of allergic rhinitis, and 4 cases of sinusitis; and 13 cases (43.4%) were ineffective, including 5 cases of chronic rhinitis, 4 cases of allergic rhinitis, and 4 cases of sinusitis; the total effective rate was 56.6%. In Comparative Example 2, 3 cases (10.0%) were clinically cured, including 1 case of chronic rhinitis, 2 cases of allergic rhinitis, and 0 cases of sinusitis; and 7 cases showed significant improvement. 23.3% of the cases were effective, including 2 cases of chronic rhinitis, 4 cases of allergic rhinitis, and 1 case of sinusitis; 20 cases (66.7%) were ineffective, including 7 cases of chronic rhinitis, 4 cases of allergic rhinitis, and 9 cases of sinusitis; the total effective rate was 33.3%; in comparison, 0 cases (0%) were clinically cured; 7 cases (23.3%) showed significant improvement, including 3 cases of chronic rhinitis, 2 cases of allergic rhinitis, and 2 cases of sinusitis; 23 cases (76.7%) were ineffective, including 7 cases of chronic rhinitis, 8 cases of allergic rhinitis, and 8 cases of sinusitis; the total effective rate was 23.3%.

[0070] In summary, this invention provides a traditional Chinese medicine nebulizer for treating rhinitis, its preparation method, and its application. The nebulizer is suitable for various types of rhinitis, such as acute rhinitis, chronic rhinitis, allergic rhinitis, and sinusitis, and significantly relieves symptoms such as nasal congestion, runny nose, decreased sense of smell, headache, memory loss, and fatigue. Furthermore, the nebulizer has a positive preventative and therapeutic effect on early-stage rhinitis and also provides relief for mature rhinitis. It is characterized by good efficacy, convenient portability, minimal discomfort, and no side effects.

[0071] The above content is merely an example and illustration of the present invention. Any modifications or additions to the specific embodiments described, or substitutions made by those skilled in the art without creative effort, shall still fall within the scope of protection of this patent.

Claims

1. A traditional Chinese medicine nebulizer solution for treating rhinitis, characterized in that, It is made from the following ingredients in parts by weight: 20 parts nutmeg, 45 parts cloves, 15 parts rhodiola rosea, 20 parts cardamom, 20 parts amomum tsao-ko, 20 parts chebula, and 20 parts costus root. The preparation method of the atomizing fluid includes the following steps: (1) Add the crushed medicinal materials and extraction solvent into a container, heat to 50~95 ℃, stir until evenly mixed, keep warm and stir for 30~120 min, centrifuge, take the supernatant and filter to obtain the raw medicine; (2) Add solvent to the raw medicinal material obtained in step (1) to adjust the concentration of raw medicinal material in the liquid to 0.4~0.5 g / g of raw medicinal material, sterilize, and fill to obtain the product; The extraction solvent includes water, ethanol, or propylene glycol.

2. The herbal nebulizer solution for treating rhinitis as described in claim 1, characterized in that, When adjusting the concentration of raw medicinal materials with solvent, the mass ratio of raw medicinal materials to solvent in the liquid is 1:1 to 10.

3. The use of the traditional Chinese medicine atomizing liquid for treating rhinitis as described in any one of claims 1 to 2 in the preparation of electronic cigarettes.

4. An electronic cigarette, characterized in that, The traditional Chinese medicine atomizing liquid for treating rhinitis as described in any one of claims 1 to 2 is used as the electronic cigarette liquid.