Chrysanthemum plant-derived traditional Chinese medicine monomer composition for treating diabetic retinopathy as well as preparation method and application thereof

By preparing a specific ratio of chrysanthemum plant-based herbal monomer composition, the problems of complex components and unstable efficacy of herbal extracts have been solved, providing a highly effective and low-side-effect treatment for diabetic retinopathy, and significantly improving the condition of retinal tissue.

CN122005589APending Publication Date: 2026-05-12ANHUI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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Patent Information

Application Number
CN202610222787.9
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-02-25
Publication Date
2026-05-12

AI Technical Summary

Technical Problem

Existing Chinese herbal extracts for the treatment of diabetic retinopathy suffer from problems such as complex composition, unclear targets, difficulty in quality control, and large differences in efficacy. In addition, conventional treatment methods have significant side effects and are difficult to effectively alleviate the condition.

Method used

A specific ratio of chrysanthemum plant-derived medicinal monomers, including chlorogenic acid, cryptochlorogenic acid, and other compounds, was used to prepare a well-defined medicinal monomer composition for the treatment of diabetic retinopathy through steps such as heating and reflux extraction, resin adsorption, and enzyme treatment.

Benefits of technology

It significantly inhibits retinopathy caused by high blood sugar, lowers blood sugar levels, improves retinal tissue structure, inhibits cell apoptosis and inflammatory response, and has few side effects, providing a more effective treatment option for diabetic retinopathy.

✦ Generated by Eureka AI based on patent content.
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Abstract

The invention discloses a traditional Chinese medicine monomer composition derived from chrysanthemum plants and used for treating diabetic retinopathy as well as a preparation method and application of the traditional Chinese medicine monomer composition. The traditional Chinese medicine monomer composition prepared from the chrysanthemum plant as the raw material is high in safety, small in side effect and definite in component and is prepared according to a specific ratio, and pharmacodynamic experiments prove that compared with an ethanol extract, the traditional Chinese medicine monomer composition is more remarkable in curative effect on diabetic retinopathy, and the curative effect of the traditional Chinese medicine monomer composition on diabetic retinopathy is better than that of a traditional Chinese medicine composition on diabetic retinopathy. The composition can improve the pathological state of diabetic retinopathy from multiple targets and multiple ways, specifically can inhibit body mass increase caused by high glucose, reduce blood glucose level, improve retinal tissue structure damage, recover retinal tissue thickness, inhibit retinal cell apoptosis and inflammatory response, reduce the expression level of HIF-1alpha and VEGF protein in retinal tissue, and can be used for treating diabetic retinopathy. Scientific basis and technical support are provided for research and development of novel drugs for treating the diabetic retinopathy, and important clinical significance and market application prospects are achieved.
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