A miniature probe for a portable nuclear magnetic resonance detection device

Abstract

The invention discloses a detachable miniature probe for a portable nuclear magnetic resonance detection device, comprising a horizontal support (01), a movable sample chamber support (02), a sample chamber (03) and a probe (04); wherein the sample chamber (03) is located in the movable sample chamber support (02), the movable sample chamber support (02) is located in the horizontal support (01), the probe (04) is located at the lower part of the movable sample chamber support (02), and the movable sample chamber support (02) supports the movement of the sample chamber (03) to ensure that the position of the newly replaced sample chamber is consistent with the original sample chamber. The invention has the advantages that a small amount of sample can be used to obtain a detection result, the miniaturization and lightness of the device are achieved, the key components such as the horizontal support structure, the movable sample chamber support structure, the sample chamber structure and the probe structure are low in manufacturing cost, and are easy to carry and assemble.

Description

Technical Field

[0001] The present invention relates to a nuclear magnetic resonance device, in particular to a miniature probe of a portable nuclear magnetic resonance detection device. Background Art

[0002] Traditional NMR instruments are bulky and have high manufacturing and maintenance costs, which has limited the promotion of NMR technology. In recent years, with the advancement of manufacturing technology and integrated electronic circuit technology, portable NMR instruments have been increasingly developed and gradually began to be used for the detection of biological samples. Portable NMR instruments generally have a relatively small sample cavity. When used for biological sample detection, if the traditional test tube method is used, it is difficult to quickly load the sample. The current micro-probe structure integrates the sample cavity and the micro-coil. During detection, when the sample cavity is reused, it is easily contaminated by the test sample. If a disposable type is used, the entire micro-probe will be discarded. On the one hand, the cost is too high, and on the other hand, it is difficult to ensure the consistency of the parameters of each batch due to the probe, which affects the final NMR measurement results.

[0003] Beneficial effects: The present invention proposes a microprobe with a separate sample cavity and microcoil. The sample cavity is disposable, and the microcoil and tuning and matching circuit are reusable, which effectively ensures the feasibility of portable nuclear magnetic resonance instruments in microbial sample detection.

[0004] With MRI imaging already in use, further popularizing MRI detection methods and enabling widespread application requires improving the mobility, speed, and practicality of MRI biological sample detection, streamlining operational procedures, and reducing costs. Consequently, small MRI devices with simple structures, ease of operation, excellent flexibility, and low cost have emerged. Summary of the Invention

[0005] Technical problem: In response to the problems of high purchase cost, poor flexibility, and complex operation and installation of existing nuclear magnetic resonance detection probes, the present invention proposes a miniature probe for a portable nuclear magnetic resonance detection device to achieve the goals of flexible movement, easy installation and operation, rapid detection, and obtaining test results with a small amount of sample.

[0006] Technical solution: The present invention adopts a detachable miniature probe for a portable nuclear magnetic resonance detection device, which includes: a horizontal support, a movable sample chamber support, a sample chamber and a probe; wherein, the sample chamber is located in the movable sample chamber support, the movable sample chamber support is located in the horizontal support, the probe is located in the lower part of the movable sample chamber support, and the movable sample chamber support supports the movement of the sample chamber to ensure that the newly replaced sample chamber is in the same position as the original sample chamber.

[0007] The lower part of the horizontal support is provided with a probe guide rail for placing the probe, and the middle part of the horizontal support is provided with a sliding guide rail for placing the movable sample chamber support; raised positioning points are provided on both sides of the sliding guide rail for accurately positioning the movable sample chamber support in the working position; one end of the horizontal support is provided with a guide rail at the same height as the sliding guide rail to facilitate the extraction and insertion of the movable sample chamber support.

[0008] The side of the movable sample chamber support is provided with a positioning hole that matches the raised positioning point in the horizontal support; the movable sample chamber support is provided with a sample chamber groove, the bottom of the sample chamber groove is provided with a lower hole, and the side of the sample chamber groove is provided with a side opening to facilitate the placement and removal of the sample chamber.

[0009] The sample cavity is in the shape of a cuboid, with an inclined chamfer on one side of the bottom surface, which is convenient for clamping the sample cavity with tweezers; a sample groove is provided in the center of the sample cavity, the upper part of the sample groove is a funnel-shaped groove, and the lower part is a cylindrical groove, which is convenient for sample dripping and collection.

[0010] The probe includes a PCB rectangular base plate, a micro coil, a tuning capacitor, a tuning inductor, and an SMA connector, wherein one end of the SMA connector is grounded and the other end is connected to the tuning capacitor; one end of the micro coil is grounded and the other end is connected to the tuning inductor, and the other end of the tuning inductor is connected to the tuning capacitor.

[0011] The SMA connector is used to output the pulse signal sequence required for the probe detection and receive the return signal detected by the probe. The probe circuit is connected to the duplexer to generate a radio frequency field and receive nuclear magnetic resonance signals.

[0012] When the microprobe is used for testing, the probe is pre-installed, the movable sample chamber support is pulled out from the horizontal support, the sample is dripped into the funnel-shaped groove of the sample chamber using an injection gun, and a cover glass is placed on it. The sample chamber is placed into the movable sample chamber support by hand or with tweezers, and the movable sample chamber support is reinserted into the horizontal support for testing. After use, the sample chamber and the cover glass are discarded.

[0013] Beneficial effects: Compared with the prior art, the present invention has the following characteristics:

[0014] 1. The present invention has a small number of parts, a compact structure, strong stability, and low cost, and can be assembled quickly and conveniently, is easy to operate, and is easy to move.

[0015] 2. The horizontal support structure of the present invention is provided with a PCB probe guide rail, and the probe structure is fixed in the guide rail, which is convenient for installing and replacing the probe structure; the present invention is provided with a sliding guide rail, and the movable sample chamber support structure slides on the guide rail, which is convenient for loading the sample chamber.

[0016] 3. The sample chamber and cover glass used in the present invention are both disposable parts, low in cost and easy to operate; the design can ensure the cleanliness of the sample chamber and the accuracy of the nuclear magnetic resonance detection results. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 It is a schematic diagram of the explosion of the components of the present invention;

[0018] Figure 2 Schematic diagram of the structure of the horizontal support structure of the present invention;

[0019] Figure 3 Schematic diagram of the movable sample chamber support structure of the present invention;

[0020] Figure 4 Schematic diagram of the sample chamber in the present invention;

[0021] Figure 5 is the equivalent circuit diagram;

[0022] Figure 6 It is a schematic diagram of the positions of components of the present invention when in working or non-working state.

[0023] The figure includes: horizontal support 01, movable sample chamber support 02, sample chamber 03, probe 04, probe guide 01a, sliding guide 01b, raised positioning point 01c, guide guide 01d, sample chamber groove 02a, lower hole 02b, side opening 02c, positioning point groove 02d, inclined chamfer 03a, funnel-shaped groove 03b, cylindrical groove 03c, SMA connector 04a, tuning capacitor 04b, tuning inductor 04c, and micro coil 04d. DETAILED DESCRIPTION

[0024] In order to make the above-mentioned objects, features and advantages of the present invention more clearly described, specific embodiments of the present invention are described in detail below with reference to the accompanying drawings.

[0025] like Figure 1 As shown, the present invention provides a miniature probe for a portable nuclear magnetic resonance detection device, comprising a horizontal support 01, a movable sample chamber support 02, a sample chamber 03, and a probe 04; wherein, the sample chamber 03 is located in the movable sample chamber support 02, the movable sample chamber support 02 is located in the horizontal support 01, and the probe 04 is located in the lower part of the movable sample chamber support 02. The movable sample chamber support 02 supports the movement of the sample chamber 03 to ensure that the newly replaced sample chamber is in the same position as the original sample chamber.

[0026] like Figure 2-5As shown, the horizontal support 01 of the present invention is equipped with a probe guide rail 01a, a sliding guide rail 01b, a raised positioning point 01c for positioning and fixing the movable sample chamber support 02, and a guide rail 01d for supporting the weight while facilitating the insertion and removal of the movable sample chamber. The movable sample chamber support 02 is provided with a sample chamber groove 02a, a lower hole 02b, and a side opening 02c for facilitating the placement and removal of the sample chamber, and a positioning point groove 02d for positioning. The sample chamber structure includes an inclined chamfer 03a, a funnel-shaped groove 03b for facilitating sample injection, and a cylindrical groove 03c. The probe structure includes an SMA connector 04a, a tuning capacitor 04b, a tuning inductor 04c, and a microcoil 04d. The probe structure is connected to a duplexer circuit to generate an RF field and receive nuclear magnetic resonance signals. One end of the SMA connector 04a is grounded, and the other end is connected to the tuning capacitor 04b; one end of the micro coil 04d is grounded, and the other end is connected to the tuning inductor 04c; and the other end of the tuning inductor 04c is connected to the tuning capacitor 04b.

[0027] like Figure 6 As shown in the working position of the probe, each time it works, the movable sample chamber support 02, which is the core component, needs to be fixed in a certain position and positioned by the matching of the raised positioning point 01c and the positioning point groove 02d; the friction provided by the movable sample chamber support and the sliding guide rail 01b works together to prevent the movable sample chamber support from moving during work; when the probe is working, the sample chamber 03 is placed in the sample chamber groove 02a.

Claims

1. A detachable miniature probe for a portable nuclear magnetic resonance detection device, characterized in that: The invention comprises a horizontal support (01), a movable sample chamber support (02), a sample chamber (03) and a probe (04); wherein the sample chamber (03) is located in the movable sample chamber support (02), the movable sample chamber support (02) is located in the horizontal support (01), the probe (04) is located in the lower part of the movable sample chamber support (02), and the movable sample chamber support (02) supports the movement of the sample chamber (03) to ensure that the position of the newly replaced sample chamber is consistent with the original sample chamber; The lower portion of the horizontal support (01) is provided with a probe guide rail (01a) for placing the probe (04), and the middle portion of the horizontal support (01) is provided with a sliding guide rail (01b) for placing the movable sample chamber support (02); The movable sample chamber support (02) is provided with a positioning hole on the side thereof, which matches the raised positioning point (01c) in the horizontal support (01); the movable sample chamber support (02) is provided with a sample chamber groove (02a); The sample cavity (03) is in the shape of a rectangular parallelepiped, and an inclined chamfer (03a) is provided on one side of the bottom surface to facilitate the use of tweezers to grasp the sample cavity (03); a sample groove is provided in the center of the sample cavity (03); The probe (04) comprises a PCB rectangular base plate, a micro coil (04d), a tuning capacitor (04b), a tuning inductor (04c), and an SMA connector (04a), wherein one end of the SMA connector (04a) is grounded, and the other end is connected to the tuning capacitor (04b); one end of the micro coil (04d) is grounded, and the other end is connected to the tuning inductor (04c), and the other end of the tuning inductor (04c) is connected to the tuning capacitor (04b).

2. A miniature probe for a portable nuclear magnetic resonance detection device according to claim 1, characterized in that: The sliding guide rail (01b) is provided with raised positioning points (01c) on both sides for accurately positioning the movable sample chamber support (02) at the working position; one end of the horizontal support (01) is provided with a guide rail (01d) at the same height as the sliding guide rail (01b) to facilitate the extraction and insertion of the movable sample chamber support (02).

3. The miniature probe for a portable nuclear magnetic resonance detection device according to claim 1, wherein: The bottom of the sample cavity groove (02a) is provided with a lower hole (02b), and the side of the sample cavity groove (02a) is provided with a side opening (02c) to facilitate the placement and removal of the sample cavity (03).

4. The miniature probe for a portable nuclear magnetic resonance detection device according to claim 1, wherein: The upper portion of the sample tank is a funnel-shaped tank (03b), and the lower portion is a cylindrical tank (03c), which facilitates the dripping and collection of samples.

5. The miniature probe for a portable nuclear magnetic resonance detection device according to claim 1, wherein: The SMA connector (04a) is used to output a pulse signal sequence required for detection by the probe (04) and to receive a return signal detected by the probe.

6. The miniature probe for a portable nuclear magnetic resonance detection device according to claim 1, wherein: When the micro probe is used for detection, the probe (04) is pre-installed, the movable sample chamber support (02) is pulled out from the horizontal support (01), the sample is dripped into the funnel-shaped groove of the sample chamber (03) using an injection gun, a cover glass is placed, the sample chamber is placed into the movable sample chamber support (02) by hand or with tweezers, and the movable sample chamber support (02) is reinserted into the horizontal support (01) to perform detection.

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