Biological tissue dielectric property measurement probe and its calibration method, equipment and medium

Abstract

The present invention relates to the technical field of dielectric property measurement of biological tissues, and in particular to a measurement probe for dielectric properties of biological tissues, its calibration method, device, and medium, including: a connection port, a coaxial transmission device, and a measurement head sequentially arranged from the bottom end to the top end of the probe. The present invention completes the measurement of the tissue to be measured through the coaxial transmission device and the measurement head, solving the problems of low electrical safety, biological invasiveness, low measurement accuracy in the low-frequency band, and difficult maintenance of the existing probe, and when the open end face of the probe is no longer exposed, the existing technology lacks a matching measurement calibration method. The measurement probe provided by the present invention can not only better improve the fit degree of the contact surface between the measurement head and the tissue to be measured, but also avoid direct contact between the metal inner core in the coaxial transmission device and the tissue to be measured, reducing the trauma to the tissue to be measured and improving the measurement accuracy, and has good application prospects.

Description

Technical Field

[0001] The present invention relates to the technical field of dielectric property measurement of biological tissues, and in particular to a probe for measuring the dielectric properties of biological tissues, and a calibration method, device and medium therefor. Background Art

[0002] Dielectric properties are the inherent physical properties of substances, and their physical representations are relative permittivity and conductivity. In biological tissues, the values of dielectric properties are closely related to factors such as the water content of cells, the intracellular ion concentration, the cell membrane permeability, and the tissue microenvironment. When the tissue undergoes pathological changes, the values of dielectric properties also change. Therefore, the dielectric properties of biological tissues can be used as a biomarker to reflect the current physiological or pathological state of the tissue and provide valuable disease diagnosis information.

[0003] The open-ended coaxial dielectric measurement technique is to emit and receive reflected electromagnetic waves to the tissue to be measured through a measurement probe, and calculate the dielectric properties of the tissue based on the reflection coefficient information of the transmitted and received electromagnetic waves. It is one of the most important techniques for measuring the dielectric properties of biological tissues at present. This technique has many advantages such as simple measurement steps, convenient operation, good practicability, and high accuracy, and is widely used in the research and application of biological tissue dielectric measurement. The existing probe for the open-ended coaxial dielectric measurement technique is an open-ended coaxial probe, which includes a three-layer coaxial cylindrical structure: a metal inner core is arranged in the innermost layer, a dielectric material is arranged in the middle layer, and a metal shielding layer is arranged in the outermost layer. A port connected to the measurement device is arranged at the bottom end of the probe, and the top end is an open end surface in contact with the tissue to be measured. On the open end surface of the probe, the three coaxial cylinders are exposed. During measurement, the measurement probe needs to be closely attached to or inserted into the tissue to be measured. At the same time, it is a coaxial transmission device for transmitting electromagnetic signals. The above structural characteristics result in the following defects of the existing measurement probe:

[0004] (1) Low electrical safety. Since the metal inner core and the outer metal shielding layer of the existing probe are in direct contact with the tissue to be measured on the open end surface, and the bottom end of the probe is electrically connected to the measurement device through an interface, when there is a leakage or a measurement device failure, the current can enter the tissue to be measured through the probe, posing a risk of electric shock.

[0005] (2) Having biological invasiveness. When the existing probe is used for measurement, it is necessary to press the probe against the tissue to be measured to ensure that the tissue is pressed into a flat surface at the contact surface of the probe. This external force extrusion of the tissue to be measured will increase the risk of damage and bleeding at the measurement site, having a certain degree of biological invasiveness and inaccurate measurement results.

[0006] (3) Low measurement accuracy in the low-frequency band. When measuring the dielectric properties of biological tissues in the low-frequency band (below 50 MHz), an obvious polarization effect occurs in the area near the probe, and the polarization effect will reduce the measurement accuracy.

[0007] (4) Difficult maintenance. When the existing probe is in measurement, the inner copper core is exposed to the tissue to be measured, which is extremely likely to cause oxidation and wear of the copper core of the probe. Once the copper core is oxidized or worn, the electrical characteristics of the probe will be changed, reducing the measurement accuracy. Although platinum plating can alleviate the oxidation of the copper core, this method not only increases the cost, but the wear problem remains unsolved.

[0008] The above problems have to a certain extent restricted the application of the current biological tissue dielectric property measurement probe in the measurement technology of biological tissue dielectric properties.

[0009] In addition, since characteristic parameter information is required during the process of measuring biological dielectric properties, before using the probe to measure the dielectric properties of tissues, it is necessary to determine the characteristic parameters of the probe. The process of determining the probe characteristic parameters is called probe measurement calibration. The existing probe measurement calibration method is to calibrate by measuring the three groups of transmission coefficients of short circuit, open circuit, and load respectively. The premise for realizing this method is that the inner core and the shielding layer metal in the open end face of the probe are exposed and can be directly connected to the short circuit, open circuit, and load terminals. However, when the open end face of the probe is no longer exposed and it is impossible to connect to the short circuit, open circuit, or load terminal, a matching measurement calibration method is required. Summary of the Invention

[0010] The present invention provides a biological tissue dielectric property measurement probe, its calibration method, device, and medium, aiming to solve the technical problems that the existing probe has low electrical safety, biological invasiveness, low measurement accuracy in the low-frequency band, and difficult maintenance, and when the open end face of the probe is no longer exposed, the existing technology lacks a matching measurement calibration method.

[0011] To solve the above technical problems, the present invention provides a biological tissue dielectric property measurement probe, its calibration method, device, and medium.

[0012] In the first aspect, the present invention provides a biological tissue dielectric property measurement probe, including: a connection port, a coaxial transmission device, and a measurement head, which are sequentially arranged from the bottom end to the top end of the probe;

[0013] The top end of the connection port is connected to the bottom end of the coaxial transmission device. The connection port includes a connection port inner core and a connection port outer shell that are on the same straight line as the central axis of the coaxial transmission device;

[0014] The coaxial transmission device includes a metal inner core, a dielectric material filling layer, and a metal shielding layer that are coaxially arranged from the inside to the outside in sequence. The metal inner core is connected to the connection port inner core, the metal shielding layer is connected to the connection port outer shell, and the outer surface of the metal shielding layer at the connection with the measurement head is provided with a first thread;

[0015] The measurement head includes a main structure and a measurement surface provided at the top end of the measurement head. A cylindrical groove is provided at the bottom of the main structure, and a second thread matching the first thread is provided on the inner wall of the cylindrical groove so that the coaxial transmission device is fixedly connected to the measurement head.

[0016] In a further embodiment, the measurement surface includes an arc-shaped measurement surface, a flat measurement surface, and a claw-shaped measurement surface;

[0017] The measurement head further includes a negative pressure air passage and an air passage opening provided at the top end of the measurement head. The air passage opening includes a plurality of air inlet openings provided at the arc measurement surface and an air outlet opening provided at the side surface of the bottom end of the measurement head.

[0018] In a further embodiment, the connection port further includes a third thread provided at the bottom end of the connection port housing.

[0019] In a further embodiment, both the main structure and the dielectric material filling layer are filled with polytetrafluoroethylene.

[0020] In a further embodiment, the measurement surface is a needle-shaped structure;

[0021] The coaxial transmission device includes a protrusion radially extending from the top end of the metal inner core to the measurement head, and a needle-shaped slot for accommodating the protrusion is provided in the main structure of the measurement head.

[0022] In a second aspect, the present invention provides a calibration method for a dielectric property measurement probe of biological tissue. The method includes the following steps:

[0023] Place the probe in a suspended state and obtain the first reflection coefficient of the probe;

[0024] Place the measurement head of the probe in a first standard liquid and obtain the second reflection coefficient of the probe;

[0025] Place the measurement head of the probe in a second standard liquid and obtain the third reflection coefficient of the probe;

[0026] Based on the first reflection coefficient, the second reflection coefficient, and the third reflection coefficient, use a characteristic model to obtain the probe characteristic parameters;

[0027] Use the probe characteristic parameters to calibrate the probe measurement, and calculate the conductivity and dielectric constant of the tissue to be measured according to the probe characteristic parameters.

[0028] In a further embodiment, the calculation formula of the characteristic model is:

[0029]

[0030] Among them,

[0031]

[0032]

[0033] In the formula, ε r1 and ε r2 respectively represent the relative dielectric constants of the first standard solution and the second standard solution, σ1 and σ2 respectively represent the conductivities of the first standard solution and the second standard solution, f represents the measurement frequency, ε0 represents the vacuum dielectric constant, and its value is approximately 8.854187817×10 -12 F / m, j represents the imaginary part symbol of a complex number, ρ air represents the first reflection coefficient, ρ1 represents the second reflection coefficient, ρ2 represents the third reflection coefficient, and λ1, λ2, and λ3 all represent probe characteristic parameters.

[0034] In a further embodiment, the first standard solution and the second standard solution are deionized water with known dielectric properties and physiological saline with a standard concentration, respectively.

[0035] In a third aspect, the present invention also provides a computer device, including a processor and a memory. The processor is connected to the memory. The memory is used to store a computer program, and the processor is used to execute the computer program stored in the memory so that the computer device executes the steps of implementing the above method.

[0036] In a fourth aspect, the present invention also provides a computer-readable storage medium. A computer program is stored in the computer-readable storage medium, and when the computer program is executed by a processor, the steps of implementing the above method are realized.

[0037] The present invention provides a probe for measuring the dielectric properties of biological tissues, its calibration method, device and medium. The present invention sets different measurement surfaces on the measurement head to better adapt to the change of the physical shape of the tissue to be measured and improve the accuracy of measurement data. The metal inner core in the coaxial transmission device is surrounded by the measurement head, avoiding direct contact between the metal inner core and the tissue to be measured and slowing down the oxidation and wear of the metal inner core. At the same time, the present invention sets a negative pressure air duct and an air duct opening, so that the tissue to be measured is tightly attached to the measurement surface under the action of negative pressure, not only realizing the close contact between the tissue to be measured and the measurement surface, increasing the reliability of measurement data, but also reducing the risks of tissue damage and bleeding caused by strong extrusion during measurement by the existing probe. Compared with the prior art, the measurement probe provided by the present invention can directly measure on the body surface of the tissue to be measured, and has the characteristics of low cost, good detection effect and simple operation. Description of the Drawings

[0038] Figure 1 It is an overall structure diagram of a dielectric property measurement probe for biological tissues provided by an embodiment of the present invention;

[0039] Figure 2 It is a cross-sectional view of the internal structure of a dielectric property measurement probe for biological tissues provided by an embodiment of the present invention;

[0040] Figure 3 It is a cross-sectional view of the internal structure of a dielectric property measurement probe for biological tissues provided by another embodiment of the present invention;

[0041] Figure 4 It is a schematic flowchart of a calibration method for a dielectric property measurement probe for biological tissues provided by an embodiment of the present invention;

[0042] Figure 5 It is a schematic diagram of the position of the probe placed in the first standard liquid provided by an embodiment of the present invention;

[0043] Figure 6 It is a schematic diagram of the structure of a computer device provided by an embodiment of the present invention. Detailed implementation manners

[0044] The following specifically illustrates the implementation manners of the present invention in conjunction with the accompanying drawings. The given embodiments are only for illustrative purposes and should not be construed as limiting the present invention. The accompanying drawings are only for reference and illustration and do not constitute a limitation on the protection scope of the present invention's patent, because many changes can be made to the present invention without departing from its spirit and scope.

[0045] Aiming at the problems of the existing probe having low electrical safety, biological invasiveness, low measurement accuracy in the low-frequency band, and difficult maintenance, and when the open end face of the probe is no longer exposed, the existing technology lacks a matching measurement and calibration method, as Figure 1 shown, an embodiment of the present invention provides a dielectric property measurement probe for biological tissues, including: a connection port 100, a coaxial transmission device 200, and a measurement head 300 sequentially arranged from the bottom end to the top end of the probe.

[0046] In an embodiment, the top end of the connection port 100 is connected to the bottom end of the coaxial transmission device 200. The connection port is an N-type connector with a characteristic impedance of 50 ohms; in this embodiment, as Figure 2 shown, the connection port includes a connection port inner core 101 and a connection port outer shell 102 that are located on the same straight line as the central axis of the coaxial transmission device.

[0047] In one embodiment, the coaxial transmission device 200 has a cylindrical rigid body structure. The coaxial transmission device 200 includes a metal inner core 201, a dielectric material filling layer 202, and a metal shielding layer 203 that are coaxially arranged from the inside out in sequence. Among them, the metal inner core 201 is connected to the inner core 101 of the connection port, and the metal shielding layer 203 is connected to the outer shell 102 of the connection port. The metal shielding layer 203 is provided with a first thread on the outer surface connected to the measuring head.

[0048] In this embodiment, the metal inner core 201 has a cylindrical structure and is located at the center of the coaxial transmission device. The metal inner core is made of pure copper. In this embodiment, a tubular dielectric material filling layer 202 is arranged outside the metal inner core, which coincides with the central axis of the metal inner core 201. The dielectric material filling layer is preferably filled with polytetrafluoroethylene. The polytetrafluoroethylene used in this embodiment is a low-loss dielectric material, which has excellent electrical insulation, oxidation resistance, wear resistance, and long service life.

[0049] In one embodiment, the measuring head 300 includes a main body structure 301 and a measuring surface 302 provided at the top of the measuring head. A cylindrical groove is provided at the bottom of the main body structure 301. In this embodiment, the diameter of the cylindrical groove is the same as the outer diameter of the coaxial transmission, and the main body structure is filled with polytetrafluoroethylene.

[0050] In this embodiment, the metal inner core of the coaxial transmission device is enclosed by the measuring head, so that the metal inner core does not directly contact the tissue to be measured. This not only avoids damaging the biological tissue, but also slows down the oxidation and wear rate of the metal inner core. In this embodiment, the main body structure of the measuring head is filled with polytetrafluoroethylene, which has the characteristics of wear resistance, long service life, and low cost.

[0051] In one embodiment, a second thread 303 that matches the first thread is provided on the inner wall of the cylindrical groove, so that the coaxial transmission device and the measuring head are rotationally fixed by the thread. The measuring head provided in this embodiment is fixedly connected to the coaxial transmission device by the thread, which is convenient for separate disassembly and more convenient to use. For example, when the measuring head is worn, only the relatively low-cost measuring head needs to be replaced, without replacing other structures.

[0052] In one embodiment, the distance between the measuring surface and the metal inner core in the coaxial transmission device is 1 mm. The measuring surface is used to contact the tissue to be measured to achieve measurement. In this embodiment, the measuring surface 302 includes, but is not limited to, an arc-shaped measuring surface, a flat measuring surface, and a claw-shaped measuring surface. The arc-shaped measuring surface, flat measuring surface, and claw-shaped measuring surface used in this embodiment can directly measure on the surface of the tissue to be measured. Compared with a needle-type probe, non-invasive measurement can be achieved without inserting into the tissue interior.

[0053] The measuring surface provided in this embodiment has various shapes and can better adapt to the change of the physical shape of the tissue. When measuring a soft and large-volume tissue, a circular arc measuring surface can be adopted in this embodiment; when measuring a hard and large-volume tissue, a flat measuring surface can be adopted in this embodiment; when measuring a small-volume tissue, a claw-shaped measuring surface can be adopted in this embodiment; this embodiment can select and use different-shaped measuring surfaces according to the tissue to be measured in actual measurement, so as to improve the fit degree of the contact surface between the measuring head and the tissue to be measured, and further ensure that there is no gap on the contact surface.

[0054] In one embodiment, the measuring head further includes a negative pressure air duct 304 and an air duct opening provided at the top end of the measuring head. The air duct opening includes a plurality of air inlet openings 305 provided at the circular arc measuring surface and an air outlet opening 306 provided at the side surface of the bottom end of the measuring head; in this embodiment, the air outlet opening is externally connected to a negative pressure generator through a hose.

[0055] As Figure 1 shown, this embodiment provides five air inlet openings at the measuring surface at the top end of the measuring head. One of the air inlet openings is located at the center of the measuring surface, and the other four air inlet openings are located at the outer periphery of the measuring surface; by providing a negative pressure air duct and an air duct opening, the tissue to be measured is tightly attached to the measuring surface under the action of negative pressure, which not only realizes the close contact between the tissue to be measured and the measuring surface, increases the reliability of the measurement data, but also reduces the risks of tissue damage, bleeding, etc. caused by strong extrusion during measurement by the existing probe.

[0056] In one embodiment, the connection port further includes a third thread 103 provided at the bottom end of the connection port housing, and the third thread is used for externally connecting a network analyzer.

[0057] When measuring using the measurement probe provided in this embodiment, this embodiment connects the connection port of the probe to a network analyzer, and at the same time presses the measurement head of the probe against the tissue to be measured against the measurement surface through negative pressure. At this time, the connection port receives the electromagnetic signal emitted by the network analyzer and sends the electromagnetic signal to the coaxial transmission device. When the coaxial transmission device receives the electromagnetic signal, the electromagnetic signal propagates in the coaxial transmission device in the transverse electric mode towards the direction of the measurement head 300. When it reaches the measurement head, the electromagnetic wave is reflected and transmitted. Among them, the transmitted part passes through the measurement head to the interface between the measurement head and the tissue to be measured, and a reflected wave is formed again at the interface, and then returns to the network analyzer along the measurement head 300, the coaxial transmission device 200, and the connection port 100 in sequence. Finally, this embodiment calculates the tissue dielectric properties according to the transmitted-received electromagnetic wave reflection coefficient information; the measurement probe provided in this embodiment can avoid the direct contact between the tissue to be measured and the metal inner core in the coaxial transmission device, so that when this embodiment measures the low-frequency band of the dielectric properties, the polarization effect at the metal inner core has less influence on the tissue to be measured, and the accuracy of the low-frequency band measurement is improved.

[0058] In another embodiment, as Figure 3 shown, a measurement probe for biological tissue dielectric properties provided in this embodiment includes a connection port, a coaxial transmission device, and a measurement head. The structure of the connection port is the same as Figure 2 the structure shown, and the coaxial transmission device not only includes Figure 2 the structure shown, but also includes a protrusion 204 extending radially from the top of the metal inner core to the measurement head; in addition, the measurement head provided in this embodiment is different from Figure 2 the measurement head shown. The measurement head provided in this embodiment includes a main structure 311 and a measurement surface 312 provided at the top of the measurement head. A cylindrical groove is provided at the bottom of the main structure 311, and the diameter of the cylindrical groove is the same as the outer diameter of the coaxial transmission. The main structure is filled with polytetrafluoroethylene, and a second thread 313 that cooperates with the first thread is provided on the inner wall of the cylindrical groove. At the same time, the measurement surface provided at the top of the measurement head in this embodiment is a needle-shaped structure, and a needle-shaped slot is also provided in the main structure of the measurement head, and the needle-shaped slot is used to accommodate the protrusion.

[0059] The needle-shaped structure measurement surface adopted in this embodiment can be conveniently inserted into the tissue to be measured. It can not only make the tissue to be measured and the probe contact better, so as to realize the measurement of the dielectric properties inside the tissue to be measured, but also cause less trauma to biological tissues. Therefore, when the measurement surface is a needle-shaped structure, the measurement head in this embodiment can realize the measurement of the dielectric properties inside the tissue to be measured without setting a negative pressure airway and an airway opening.

[0060] The dielectric property measurement probe provided in this embodiment realizes the physical separation of the probe measurement function and the electromagnetic signal transmission function through the measurement head and the coaxial transmission device. That is, the measurement function is realized by directly contacting the measurement head with the tissue to be measured, and the electromagnetic signal is transmitted to the measurement head through the coaxial transmission device. At the same time, this embodiment uses an insulating dielectric material to fill the main structure of the measurement head, which can achieve electrical isolation and avoid the situation where current enters the tissue to be measured when the probe leaks electricity or fails, greatly improving electrical safety.

[0061] In the dielectric property measurement probe of biological tissue, since the electromagnetic signal reflects once when transmitted from the coaxial transmission device to the measurement head and reflects a second time at the interface between the measurement head and the tissue, this process will introduce new errors, which may have a greater impact on the measurement results. At the same time, the insulating dielectric material used in the measurement head cannot form a circuit connection with a short circuit, an open circuit, or a load terminal. Therefore, in one embodiment, as Figure 4 shown, this embodiment provides a calibration method for a dielectric property measurement probe of biological tissue, and the method includes the following steps:

[0062] S1. Place the probe in a suspended state and obtain the first reflection coefficient of the probe.

[0063] In this embodiment, the dielectric property measurement probe of biological tissue is placed in a suspended state, and no other objects are placed within a range of five centimeters below the measurement head of the probe. At this time, the reflection coefficient of the measurement probe in the suspended state is measured to obtain the first reflection coefficient ρ air .

[0064] S2. Place the measurement head of the probe in the first standard liquid and obtain the second reflection coefficient ρ1 of the probe.

[0065] In this embodiment, the first standard liquid is deionized water with known dielectric properties.

[0066] In this embodiment, fixtures and other fixing components are used to fix the dielectric property measurement probe of biological tissue, and the measurement head of the probe is placed in deionized water. As Figure 5 shown, in this embodiment, the probe is placed in the center of the deionized water liquid 400, and at the same time, the distance H1 between the top of the measurement head and the deionized water liquid surface is controlled to be not less than two centimeters, and the distance H2 between the top of the measurement head and the bottom of the deionized water is controlled to be not less than five centimeters to obtain the second reflection coefficient of the probe.

[0067] S3. Place the measurement head of the probe in the second standard liquid and obtain the third reflection coefficient ρ2 of the probe.

[0068] In this embodiment, the second standard liquid is physiological saline with a known standard concentration and known dielectric properties.

[0069] In this embodiment, a fixture or other fixing component is used to fix the dielectric property measurement probe of biological tissue, and the measurement head of the probe is placed in physiological saline. Similarly, in this embodiment, the probe is placed in the center of the physiological saline liquid, and at the same time, the distance H1 between the top end of the measurement head and the liquid surface of the physiological saline is controlled to be not less than two centimeters, and the distance H2 between the top end of the measurement head and the bottom of the physiological saline is not less than five centimeters, so as to obtain the third reflection coefficient of the probe.

[0070] S4. Based on the first reflection coefficient, the second reflection coefficient, and the third reflection coefficient, the probe characteristic parameters are obtained by using the characteristic model.

[0071] In this embodiment, the probe characteristic parameters include a first characteristic parameter, a second characteristic parameter, and a third characteristic parameter.

[0072] In one embodiment, the formula of the characteristic model is:

[0073]

[0074] Wherein,

[0075]

[0076]

[0077] In the formula, ε r1 、ε r2 respectively represent the relative dielectric constants of the first standard liquid and the second standard liquid, σ1 and σ2 respectively represent the conductivities of the first standard liquid and the second standard liquid, f represents the measurement frequency, ε0 represents the vacuum dielectric constant, the value of which is approximately 8.854187817×10 -12 F / m, j represents the imaginary part symbol of the complex number, ρ air represents the first reflection coefficient, ρ1 represents the second reflection coefficient, ρ2 represents the third reflection coefficient, λ1 represents the first characteristic parameter, λ2 represents the second characteristic parameter, and λ3 represents the third characteristic parameter.

[0078] S5. The probe measurement is calibrated by using the probe characteristic parameters, and the conductivity and dielectric constant of the tissue to be measured are calculated according to the probe characteristic parameters.

[0079] In this embodiment, the measurement calibration of the dielectric property measurement probe of biological tissue is completed by obtaining the three probe characteristic parameters. After the above calibration and correction, the three obtained probe characteristic parameters are used to solve the dielectric property measurement of biological tissue.

[0080] It should be noted that the magnitudes of the sequence numbers of the above processes do not mean the order of execution. The order of execution of each process should be determined by its function and internal logic, and should not constitute any limitation to the implementation process of the embodiments of the present application.

[0081] Specific limitations on a calibration method for a dielectric property measurement probe of biological tissue can be referred to the above limitations on a dielectric property measurement probe of biological tissue, which will not be elaborated here. Those of ordinary skill in the art can realize that, in combination with the various modules and steps described in the embodiments disclosed in the present application, they can be implemented in hardware, software, or a combination of both. Whether these functions are executed in a hardware or software manner depends on the specific application and design constraints of the technical solution. Professional technicians can use different methods to implement the described functions for each specific application, but such implementation should not be considered to exceed the scope of the present application.

[0082] Compared with the prior art, the calibration method for a dielectric property measurement probe of biological tissue provided by the embodiments of the present invention uses deionized water and physiological saline with known dielectric properties to calibrate the probe measurement, thereby greatly improving the accuracy of dielectric property measurement and solving the technical problem that when the open end face of the probe is no longer exposed, the prior art lacks a matching measurement and calibration method. The probe measurement calibration method provided by this embodiment is not only simple and easy to implement, highly operable, but also the first standard liquid and the second standard liquid used are easy to obtain, low in cost, and high in biocompatibility.

[0083] Figure 6 A computer device provided by the embodiments of the present invention includes a memory, a processor, and a transceiver, which are connected through a bus; the memory is used to store a set of computer program instructions and data, and can transmit the stored data to the processor, and the processor can execute the program instructions stored in the memory to perform the steps of the above method.

[0084] Among them, the memory may include volatile memory or non-volatile memory, or may include both volatile and non-volatile memory; the processor may be a central processing unit, a microprocessor, an application-specific integrated circuit, a programmable logic device, or a combination thereof. By way of example but not limitation, the above programmable logic device may be a complex programmable logic device, a field programmable gate array, a generic array logic, or any combination thereof.

[0085] In addition, the memory may be a physically independent unit or integrated with the processor.

[0086] Those of ordinary skill in the art can understand that Figure 6 the structure shown in

[0087] In one embodiment, a computer-readable storage medium is provided, on which a computer program is stored. When the computer program is executed by a processor, the steps of the above method are implemented.

[0088] A dielectric property measurement probe for biological tissue, its calibration method, device and medium provided by an embodiment of the present invention. A dielectric property measurement probe for biological tissue encloses and wraps the metal inner core in a coaxial transmission device in space through a measuring head, so that it does not contact the tissue, reducing the oxidation and wear of the metal inner core. At the same time, the dielectric material of the measuring head uses a high-strength organic material, which is not only anti-oxidant, wear-resistant, but also has a long service life. In addition, in this embodiment, the electromagnetic signal transmission function is realized through the coaxial transmission device, and it does not directly contact the tissue to be measured, avoiding the situation that when leakage occurs or the measuring device fails, the current causes harm to the tissue to be measured.

[0089] In the above embodiment, it can be implemented in whole or in part by software, hardware, firmware or any combination thereof. When implemented using software, it can be implemented in whole or in part in the form of a computer program product. The computer program product includes one or more computer instructions. When the computer program instructions are loaded and executed on a computer, the processes or functions described in the embodiments of the present invention are generated in whole or in part. The computer can be a general-purpose computer, a special-purpose computer, a computer network, or other programmable devices. The computer instructions can be stored in a computer-readable storage medium, or transmitted from one computer-readable storage medium to another computer-readable storage medium. For example, the computer instructions can be transmitted from a website, computer, server or data center to another website, computer, server or data center by wire (such as coaxial cable, optical fiber, digital subscriber line) or wireless (such as infrared, wireless, microwave, etc.). The computer-readable storage medium can be any available medium that can be accessed by a computer or a data storage device such as a server or data center that includes one or more integrated available media. The available medium can be a magnetic medium (such as a floppy disk, hard disk, magnetic tape), an optical medium (such as a DVD), or a semiconductor medium (such as an SSD), etc.

[0090] Those skilled in the art can understand that all or part of the process of implementing the method in the above embodiment can be completed by instructing relevant hardware through a computer program. The computer program can be stored in a computer-readable storage medium. When the computer program is executed, it can include the processes of the embodiments of the above methods.

[0091] The above-described embodiments merely represent several preferred embodiments of the present application. The description thereof is relatively specific and detailed, but it should not be construed as a limitation on the scope of the invention patent. It should be noted that for those of ordinary skill in the art, without departing from the technical principle of the present invention, several improvements and substitutions can be made, and these improvements and substitutions should also be regarded as the protection scope of the present application. Therefore, the protection scope of the patent of the present application shall be subject to the protection scope of the claims described above.

Claims

1. A biological tissue dielectric property measurement probe, characterized in that, Including: A connection port, a coaxial transmission device, and a measurement head sequentially arranged from the bottom end to the top end of the probe; The top end of the connection port is connected to the bottom end of the coaxial transmission device. The connection port includes a connection port inner core and a connection port outer shell that are located on the same straight line as the central axis of the coaxial transmission device; The coaxial transmission device includes a metal inner core, a dielectric material filling layer, and a metal shielding layer that are coaxially arranged from the inside to the outside in sequence. The metal inner core is connected to the connection port inner core, the metal shielding layer is connected to the connection port outer shell, and a first thread is provided on the outer surface of the metal shielding layer at the connection with the measurement head. The metal inner core of the coaxial transmission device is enclosed by the measurement head so that the metal inner core does not directly contact the tissue to be measured; The measurement head includes a main structure and a measurement surface provided at the top end of the measurement head. A cylindrical groove is provided at the bottom of the main structure, and a second thread that matches the first thread is provided on the inner wall of the cylindrical groove to fixedly connect the coaxial transmission device to the measurement head; The measurement surface is an arc-shaped measurement surface, a flat measurement surface, or a claw-shaped measurement surface; the measurement head further includes a negative pressure air channel and an air channel opening provided at the top end of the measurement head. The air channel opening includes a plurality of air inlet openings provided at the arc-shaped measurement surface and an air outlet opening provided at the side surface of the bottom end of the measurement head; by providing the negative pressure air channel and the air channel opening, the tissue to be measured is closely attached to the measurement surface under the action of negative pressure.

2. A biological tissue dielectric property measurement probe according to claim 1, wherein: The connection port further includes a third thread provided at the bottom end of the connection port outer shell.

3. The dielectric property measurement probe for biological tissue according to claim 1, wherein: Both the main structure and the dielectric material filling layer are filled with polytetrafluoroethylene.

4. The dielectric property measurement probe for biological tissue according to claim 1, wherein: The measurement surface is a needle-shaped structure; The coaxial transmission device includes a protrusion that radially extends from the top end of the metal inner core to the measurement head, and a needle-shaped slot for accommodating the protrusion is provided in the main structure of the measurement head.

5. A calibration method for a biological tissue dielectric property measurement probe, characterized in that, Applying the biological tissue dielectric property measurement probe according to any one of claims 1 to 4, the method includes the following steps: Placing the probe in a suspended state and obtaining the first reflection coefficient of the probe; Placing the measurement head of the probe in a first standard liquid and obtaining the second reflection coefficient of the probe; Placing the measurement head of the probe in a second standard liquid and obtaining the third reflection coefficient of the probe; Based on the first reflection coefficient, the second reflection coefficient, and the third reflection coefficient, obtaining the probe characteristic parameters by using a characteristic model; Performing probe measurement calibration by using the probe characteristic parameters and calculating the conductivity and dielectric constant of the tissue to be measured according to the probe characteristic parameters.

6. The calibration method for a biological tissue dielectric property measurement probe according to claim 5, characterized in that The calculation formula of the characteristic model is: Wherein, In the formula, and respectively represent the relative dielectric constants of the first standard liquid and the second standard liquid, and respectively represent the conductivities of the first standard liquid and the second standard liquid, f represents the measurement frequency, represents the vacuum permittivity, and its value is approximately , j represents the imaginary part symbol of a complex number, represents the first reflection coefficient, represents the second reflection coefficient, represents the third reflection coefficient, 、 、 all represent the probe characteristic parameters.

7. A calibration method for a biological tissue dielectric property measurement probe according to claim 5, characterized in that: The first standard liquid and the second standard liquid are deionized water and physiological saline with a standard concentration, respectively, whose dielectric properties are known.

8. A computer device, characterized in that: Including a processor and a memory. The processor is connected to the memory. The memory is used to store a computer program, and the processor is used to execute the computer program stored in the memory so that the computer device executes the method according to any one of claims 5 to 7.

9. A computer-readable storage medium, characterized in that: A computer program is stored in the computer-readable storage medium, and when the computer program is run, the method according to any one of claims 5 to 7 is implemented.

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