Raw material medicine freeze-drying machine discharge system capable of being cleaned and sterilized and cleaning and sterilizing method

Abstract

The online cleaning and sterilizing raw material medicine freeze-drying machine discharge system comprises a freeze-drying box, a cleaning and sterilizing tank, an isolator, and a suction gun and a suction gun driving device, the freeze-drying box and the cleaning and sterilizing tank are located on the same side of the isolator, the freeze-drying box and the cleaning and sterilizing tank are respectively provided with a discharge door and a cleaning and sterilizing door on the side close to the isolator, the suction gun is connected with a discharge pipe assembly, the discharge pipe assembly extends to the outside of the isolator, the suction gun is provided with a sealing seat, the other end of the suction gun is arranged between a pair of guide wheels, and the pair of guide wheels are connected with an adjusting mechanism. The cleaning and sterilizing method comprises the following steps: S1, raw material medicine discharge; S2, after the raw material medicine discharge is completed, the suction gun driving device drives the suction gun to exit the freeze-drying box, and the discharge door is closed; S3, online cleaning and sterilization of the suction gun; and S4, after the online cleaning and sterilization is completed, the suction gun driving device drives the suction gun to exit the cleaning and sterilizing tank, and the cleaning and sterilizing door is closed. The present application has the advantages of simple structure, reliability, online cleaning and sterilization, etc.

Description

TECHNICAL FIELD

[0001] The present application relates to food, medicine packaging machinery and use method, and particularly relates to a raw material medicine freeze dryer discharge system capable of being cleaned and sterilized on line and a cleaning and sterilizing method. BACKGROUND

[0002] In the traditional pharmaceutical process, the raw material medicine is taken out of the freeze dryer by manually opening the door of the freeze dryer. The taking-out process of opening the door of the freeze dryer not only easily causes the raw material medicine to be contaminated, but also directly exposes the operator to the medicine environment, which easily causes adverse effects on the health of the operator. With the development of the technical level, some equipment also adopts an automatic material collecting mode to collect the material. The rear end of the material suction gun is connected with the connecting pipe of the external equipment of the isolation cavity through a hose, so that the raw material medicine in the freeze dryer is transported to the raw material medicine processing equipment through the material suction gun and the hose. However, when the material suction gun moves in the isolation cavity, the hose is dragged to move irregularly, which causes the hose to be scratched with the components in the isolation cavity, and even the hose is pulled off. In addition, the existing material suction gun is cleaned and sterilized in an offline mode, that is, the gun head of the material suction gun is disassembled, then the gun head is cleaned and sterilized in a sterilizing tank, and then a sealing bag is used to cover the gun head. Finally, the gun head is installed. The operation process is complicated, the efficiency is low, and secondary pollution is easily caused. SUMMARY

[0003] The present application solves the technical problems of the prior art, and provides a raw material medicine freeze dryer discharge system which is simple in structure, reliable, and capable of being cleaned and sterilized on line.

[0004] The present application further provides a cleaning and sterilizing method of the raw material medicine freeze dryer discharge system which can be cleaned and sterilized on line.

[0005] To solve the above technical problems, the present application adopts the following technical solutions:

[0006] A raw material medicine freeze dryer discharge system capable of being cleaned and sterilized on line comprises a freeze dryer, a cleaning and sterilizing tank, an isolator, a material suction gun and a material suction gun driving device arranged in the isolator. The freeze dryer and the cleaning and sterilizing tank are located on the same side of the isolator. The freeze dryer is provided with a discharge door on the side close to the isolator. The cleaning and sterilizing tank is provided with a cleaning and sterilizing door on the side close to the isolator. The material suction gun is connected with a discharge pipe assembly. The discharge pipe assembly extends to the outside of the isolator. The end of the material suction gun connected with the discharge pipe assembly is provided with a sealing seat for sealing the cleaning and sterilizing door. The other end of the material suction gun penetrates between a pair of guide wheels. A pair of guide wheels are connected with an adjusting mechanism for adjusting the distance between the pair of guide wheels.

[0007] As a further improvement of the above technical solution: the adjusting mechanism comprises an adjusting screw rod, the screw rod is provided with a nut seat at each end, and a pair of guide wheels are installed on the nut seats.

[0008] As a further improvement of the above technical solution: the adjusting screw rod is connected with an adjusting handle at one end, and an operating glove is arranged on the isolator.

[0009] As a further improvement of the above technical solution: the cleaning and sterilizing tank comprises a tank body, a cleaning water inlet, a steam inlet and a discharge port arranged on the tank body.

[0010] As a further improvement of the above technical solution: the tank body is provided with a safety valve, a pressure sensor and an overflow port.

[0011] As a further improvement of the above technical solution: the discharge pipe assembly comprises a first rotary joint, a first discharge hard pipe, a second rotary joint, a second discharge hard pipe, a third rotary joint and a third discharge hard pipe connected in sequence, the suction gun is connected with the first rotary joint, and the third discharge hard pipe extends out of the isolator.

[0012] As a further improvement of the above technical solution: the suction gun driving device comprises a first driving mechanism for driving the suction gun to reciprocate between the discharge door and the cleaning and sterilizing door, a second driving mechanism for driving the suction gun to enter and exit the discharge door and the cleaning and sterilizing door, and a third driving mechanism for driving the suction gun to ascend and descend.

[0013] As a further improvement of the above technical solution: the first driving mechanism comprises a first guide rail, a first sliding seat arranged on the first guide rail, and a first driving belt for driving the first sliding seat to reciprocate along the first guide rail, the third driving mechanism comprises a lifting driving member arranged on the first sliding seat and a lifting seat connected with the lifting driving member, and the second driving mechanism comprises a second guide rail arranged on the lifting seat, a second sliding seat arranged on the second guide rail, and a second driving belt for driving the second sliding seat to reciprocate along the second guide rail, the suction gun is arranged on the second sliding seat, and the second driving belt is arranged on the lifting seat.

[0014] A cleaning and sterilizing method of the above-mentioned raw material drug freeze dryer discharge system which can be cleaned and sterilized online, comprising the following steps,

[0015] S1, raw material drug discharging: after the raw material drug is freeze-dried, the discharge door is opened, the suction gun driving device drives the suction gun to extend into the freeze-drying box, the suction gun sucks the raw material drug on the freeze-drying plate layer through negative pressure and outputs to the outside of the isolator through the discharge pipe assembly;

[0016] S2, after the raw material drug of each freeze-drying plate layer is discharged, the suction gun driving device drives the suction gun to exit the freeze-drying box, and the discharge door is closed;

[0017] S3, the suction gun is cleaned and sterilized online:

[0018] S3.1, the cleaning and sterilization door is opened, the suction gun driving device drives the suction gun to extend into the cleaning and sterilization tank, a pair of guide wheels provide a guide function for the suction gun, and the suction gun stops when the sealing seat approaches the pair of guide wheels;

[0019] S3.2, the adjusting mechanism increases the distance between the pair of guide wheels until the sealing seat can pass between the pair of guide wheels;

[0020] S3.3, the suction gun driving device drives the suction gun to continue to extend into the cleaning and sterilization tank until the sealing seat is tightly sealed with the cleaning and sterilization door;

[0021] S3.4, the cleaning and sterilization tank cleans and sterilizes the suction gun;

[0022] S4, after the online cleaning and sterilization is completed, the suction gun driving device drives the suction gun to exit the cleaning and sterilization tank, the cleaning and sterilization door is closed, and the sealing seat passes between the pair of guide wheels, and the adjusting mechanism drives the pair of guide wheels to return to the original position.

[0023] As a further improvement of the above technical solution:

[0024] In step S3.2, the adjusting handle is rotated by operating the glove, the adjusting handle drives the adjusting screw rod to rotate, the nut seats at both ends of the adjusting screw rod move along the adjusting screw rod and move away from each other, and the distance between the pair of guide wheels increases with the movement of the two nut seats.

[0025] Compared with the prior art, the raw material drug freeze-drying machine discharge system disclosed by the application can be cleaned and sterilized online, the freeze-drying box and the cleaning and sterilization tank are arranged on the same side of the isolator, the discharge door and the cleaning and sterilization door are arranged on the freeze-drying box and the cleaning and sterilization tank respectively, the suction gun is driven to move by the suction gun driving device, the discharge door is opened after freeze-drying, the suction gun moves above the freeze-drying plate layer to suck the raw material drug by negative pressure, and the raw material drug is output to the raw material drug processing equipment through the discharge pipe assembly, the suction gun exits the freeze-drying box after the raw material drug on each freeze-drying plate layer is discharged, and the discharge door is closed; then the cleaning and sterilization door is opened, a pair of guide wheels provide support and guide function for the suction gun, the suction gun gradually extends into the cleaning and sterilization tank, when the sealing seat needs to pass through the pair of guide wheels, the adjusting mechanism increases the distance between the pair of guide wheels so that the sealing seat can pass through, the sealing seat is tightly sealed with the cleaning and sterilization door after passing through, the cleaning and sterilization tank is airtight environment, the cleaning and sterilization tank cleans and sterilizes the suction gun online, the structure is simple and reliable, the degree of automation is high, and secondary pollution is avoided.

[0026] The cleaning and sterilization method disclosed by the application has high automation degree and high operation efficiency, can realize online cleaning and sterilization of the suction gun, and avoids the secondary pollution problem existing in offline cleaning and sterilization. BRIEF DESCRIPTION OF DRAWINGS

[0027] Figure 1 is a three-dimensional structural schematic diagram of a raw material drug freeze dryer discharge system capable of online cleaning and sterilization according to the application.

[0028] Figure 2 is a structural schematic diagram when the application is preparing for discharge.

[0029] Figure 3 is a structural schematic diagram when the application is preparing for cleaning and sterilization.

[0030] Figure 4 is an enlarged structural schematic diagram of a guide wheel in the application.

[0031] Figure 5 is a structural schematic diagram of a cleaning and sterilization tank in the application.

[0032] The various reference numbers in the figure represent: 1, freeze dryer box; 11, discharge door; 12, freeze drying plate layer; 2, cleaning and sterilization tank; 21, cleaning and sterilization door; 22, tank body; 23, cleaning water inlet; 24, steam inlet; 25, discharge outlet; 26, safety valve; 27, pressure sensor; 28, overflow port; 29, air charging sealing ring; 3, isolator; 31, operating glove; 4, suction gun; 41, sealing seat; 5, suction gun driving device; 51, first driving mechanism; 511, first guide rail; 512, first sliding seat; 513, first driving belt; 52, second driving mechanism; 521, second guide rail; 522, second sliding seat; 523, second driving belt; 53, third driving mechanism; 531, lifting driving piece; 532, lifting seat; 6, discharge pipe assembly; 61, first rotary joint; 62, first discharge hard pipe; 63, second rotary joint; 64, second discharge hard pipe; 65, third rotary joint; 66, third discharge hard pipe; 7, guide wheel; 71, adjusting mechanism; 72, adjusting screw; 73, nut seat; 74, adjusting handle. DETAILED DESCRIPTION

[0033] The application will be further described in detail below in combination with the drawings and specific embodiments of the specification.

[0034] Example One

[0035] Figures 1 to 4An embodiment of the online cleanable and sterilizable bulk drug freeze dryer discharge system is shown. The online cleanable and sterilizable bulk drug freeze dryer discharge system of the embodiment comprises a freeze drying box 1, a cleanable and sterilizable tank 2, an isolator 3, a suction gun 4 and a suction gun driving device 5 arranged in the isolator 3. The freeze drying box 1 and the cleanable and sterilizable tank 2 are located on the same side of the isolator 3. The freeze drying box 1 is provided with a discharge door 11 on the side close to the isolator 3. The cleanable and sterilizable tank 2 is provided with a cleanable and sterilizable door 21 on the side close to the isolator 3. The suction gun 4 is connected with a discharge pipe assembly 6 extending out of the isolator 3. The end of the suction gun 4 connected with the discharge pipe assembly 6 is provided with a sealing seat 41 for sealing the cleanable and sterilizable door 21. The other end of the suction gun 4 penetrates between a pair of guide wheels 7. The pair of guide wheels 7 are connected with an adjusting mechanism 71 for adjusting the distance between the pair of guide wheels 7.

[0036] After the freeze drying is completed, the discharge door 11 is opened, the suction gun 4 moves above the freeze drying plate layer 12 to suck the bulk drug by negative pressure, preferably, moves along an S-shaped path, completes the suction of the whole freeze drying plate layer 12, and outputs the bulk drug to a bulk drug processing device through the discharge pipe assembly 6. Then the suction gun 4 exits the freeze drying box 1, the next freeze drying plate layer 12 is lowered to the discharge position, the suction gun 4 enters the freeze drying box 1 again to suck the bulk drug, and the cycle is repeated. After the bulk drug on each freeze drying plate layer 12 is completely discharged, the suction gun 4 exits the freeze drying box 1, and the discharge door 11 is closed. Then the cleanable and sterilizable door 21 is opened, the pair of guide wheels 7 provide support and guidance for the suction gun 4, the suction gun 4 gradually extends into the cleanable and sterilizable tank 2, when the sealing seat 41 needs to pass through the pair of guide wheels 7, the adjusting mechanism 71 increases the distance between the pair of guide wheels 7 so that the sealing seat 41 can pass through. After the sealing seat 41 passes through, it abuts against the cleanable and sterilizable door 21 to seal, preferably, an inflatable sealing ring 29 is arranged on the cleanable and sterilizable door 21, after the sealing seat 41 abuts against the cleanable and sterilizable door 21, the inflatable sealing ring 29 inflates to fill the gap between them, forming a good seal, ensuring that the cleanable and sterilizable tank 2 is a closed environment, and the cleanable and sterilizable tank 2 performs online cleaning and sterilization of the suction gun 4. The structure is simple and reliable, and the degree of automation is high, avoiding secondary pollution.

[0037] Further, in the embodiment, the adjusting mechanism 71 comprises an adjusting screw rod 72, the screw directions of the two ends of the adjusting screw rod 72 are opposite, and each is provided with a nut seat 73. One of the pair of guide wheels 7 is correspondingly arranged on each of the two nut seats 73. When the distance between the pair of guide wheels 7 needs to be adjusted, the adjusting screw rod 72 is rotated, the two nut seats 73 at the two ends of the adjusting screw rod 72 move closer to or away from each other, thereby driving the pair of guide wheels 7 to move closer to or away from each other. The structure is simple and reliable, and the adjustment is convenient.

[0038] As a preferred embodiment, the adjusting handle 74 is connected to one end of the adjusting screw rod 72, and the operating glove 31 is arranged on the isolator 3. The operator can manually rotate the adjusting handle 74 outside the isolator 3 by means of the operating glove 31, thereby driving the adjusting screw rod 72 to rotate, so as to adjust the distance between the pair of guide wheels 7, without polluting the clean environment inside the isolator 3, and the structure is simple and reliable.

[0039] Further, in the embodiment, the cleaning and sterilizing tank 2 comprises a tank body 22, and a cleaning water inlet 23, a steam inlet 24 and a discharge outlet 25 arranged on the tank body 22. After the suction gun 4 enters the tank body 22 and the sealing seat 41 is tightly sealed against the cleaning and sterilizing door 21, the cleaning water enters the tank body 22 through the cleaning water inlet 23, so as to perform multiple cyclic and pulsating cleaning on the suction gun 4. The sewage can be discharged from the tank body 22 through the discharge outlet 25. After the cleaning is completed, the cleaning water inlet 23 is closed, the high-temperature steam enters the tank body 22 through the steam inlet 24 to perform high-temperature steam sterilization on the suction gun 4. After the sterilization is completed, the steam can be discharged from the tank body 22 through the discharge outlet 25. The structure is simple and reliable, and the cleaning and sterilizing effect is good. Preferably, the discharge outlet 25 is arranged at the bottom of the tank body 22, and the number thereof can be multiple and distributed at both ends of the tank body 22, which is beneficial to the rapid discharge of the cleaning water and the cleaning steam; the cleaning water inlet 23 and the steam inlet 24 are arranged at the top of the tank body 22.

[0040] In the embodiment, the tank body 22 is provided with a safety valve 26, a pressure sensor 27 and an overflow port 28. The pressure sensor 27 is used for monitoring the steam pressure in the tank body 22 in real time. When the steam pressure is too high, the safety valve 26 can be used for pressure relief to ensure safety. If the cleaning water level in the tank body 22 is too high, the overflow port 28 can be used for discharge to ensure that the liquid level in the tank body 22 is normal.

[0041] Further, in the embodiment, the discharge pipe assembly 6 comprises a first rotary joint 61, a first discharge hard pipe 62, a second rotary joint 63, a second discharge hard pipe 64, a third rotary joint 65 and a third discharge hard pipe 66 connected in sequence. The suction gun 4 is connected to the first rotary joint 61, and the third discharge hard pipe 66 extends to the outside of the isolator 3. The discharge pipe assembly 6 comprises three rotary joints and three discharge hard pipes. During the movement of the suction gun 4, each discharge hard pipe can flexibly rotate around the corresponding rotary joint, without hindering the movement of the suction gun 4, and the discharge hard pipe will not randomly move and scratch the components in the isolator 3.

[0042] Further, in the embodiment, the suction gun driving device 5 comprises a first driving mechanism 51 for driving the suction gun 4 to reciprocate between the discharge door 11 and the cleaning and sterilizing door 21, a second driving mechanism 52 for driving the suction gun 4 to enter or exit the discharge door 11 and the cleaning and sterilizing door 21, and a third driving mechanism 53 for driving the suction gun 4 to ascend and descend, so that the suction gun 4 can reciprocate between the discharge door 11 and the cleaning and sterilizing door 21, enter or exit the cleaning and sterilizing tank 2 and the freeze-drying box 1, and perform small-amplitude ascending and descending movements to pass over the raised portions of the freeze-drying plate layer 12.

[0043] As a preferred embodiment, the first driving mechanism 51 comprises a first guide rail 511, a first sliding seat 512 arranged on the first guide rail 511, and a first driving belt 513 for driving the first sliding seat 512 to reciprocate along the first guide rail 511, the third driving mechanism 53 comprises a lifting driving member 531 arranged on the first sliding seat 512 and a lifting seat 532 connected with the lifting driving member 531, and the second driving mechanism 52 comprises a second guide rail 521 arranged on the lifting seat 532, a second sliding seat 522 arranged on the second guide rail 521, and a second driving belt 523 for driving the second sliding seat 522 to reciprocate along the second guide rail 521, the suction gun 4 is arranged on the second sliding seat 522, and the second driving belt 523 is arranged on the lifting seat 532. In operation, the first driving belt 513 can drive the first sliding seat 512, the second driving mechanism 52, the third driving mechanism 53 and the suction gun 4 thereon to reciprocate along the first guide rail 511, so that the suction gun 4 can be aligned with the discharge door 11 or the cleaning and sterilizing door 21, the lifting driving member 531 can drive the lifting seat 532, the second driving mechanism 52 and the suction gun 4 thereon to perform small-amplitude ascending and descending movements, so that the suction gun 4 can pass over the raised portions of the freeze-drying plate layer 12 and then descend to the surface of the freeze-drying plate to suck out the raw material, and the second driving belt 523 can drive the second sliding seat 522 and the suction gun 4 thereon to reciprocate along the second guide rail 521, so that the suction gun 4 can enter or exit the cleaning and sterilizing tank 2 and the freeze-drying box 1. The suction gun driving device 5 has simple and reliable overall structure, compact layout and small space occupation. Of course, in other embodiments, the reciprocating movements of the suction gun 4 in various directions can also be realized by a screw-nut pair, a worm gear pair, a pneumatic cylinder or an electric push rod.

[0044] Embodiment two

[0045] The cleaning and sterilizing method of the raw material discharge system of the freeze-drying machine capable of online cleaning and sterilization comprises the following steps,

[0046] S1, raw material discharging: after the raw material is freeze-dried, the discharge door 11 is opened, the suction gun driving device 5 drives the suction gun 4 to enter the freeze-drying box 1, and the suction gun 4 sucks the raw material on the freeze-drying plate layer 12 by negative pressure and outputs the raw material to the isolator 3 outside through the discharge pipe assembly 6;

[0047] S2, after the raw material drug of each freeze-drying plate layer 12 is discharged, the suction gun driving device 5 drives the suction gun 4 to exit the freeze-drying box 1, and the discharge door 11 is closed;

[0048] S3, the suction gun 4 is cleaned and sterilized online:

[0049] S3.1, the cleaning and sterilization door 21 is opened, the suction gun driving device 5 drives the suction gun 4 to extend into the cleaning and sterilization tank 2, a pair of guide wheels 7 provide a guide function for the suction gun 4, and when the sealing seat 41 approaches the pair of guide wheels 7, the suction gun 4 stops;

[0050] S3.2, the adjusting mechanism 71 increases the distance between the pair of guide wheels 7, until the sealing seat 41 can pass between the pair of guide wheels 7;

[0051] S3.3, the suction gun driving device 5 drives the suction gun 4 to continue to extend into the cleaning and sterilization tank 2, until the sealing seat 41 is tightly sealed with the cleaning and sterilization door 21;

[0052] S3.4, the cleaning and sterilization tank 2 cleans and sterilizes the suction gun 4;

[0053] S4, after the online cleaning and sterilization is completed, the suction gun driving device 5 drives the suction gun 4 to exit the cleaning and sterilization tank 2, the cleaning and sterilization door 21 is closed, and after the sealing seat 41 passes between the pair of guide wheels 7, the adjusting mechanism 71 drives the pair of guide wheels 7 to reset, so that the pair of guide wheels 7 can clamp the suction gun 4 to provide support and guide for the extension and retraction movement of the suction gun 4.

[0054] The cleaning and sterilization method has high automation degree and high operation efficiency, can realize online cleaning and sterilization of the suction gun 4, and avoids the problem of secondary pollution existing in offline cleaning and sterilization.

[0055] Further, in the embodiment, in step S3.2, the adjusting handle 74 is rotated by operating the operating glove 31, the adjusting handle 74 drives the adjusting screw 72 to rotate, the nut seats 73 at both ends of the adjusting screw 72 move along the adjusting screw 72 and move away from each other, and the distance between the pair of guide wheels 7 increases with the movement of the two nut seats 73. The operator manually rotates the adjusting handle 74 outside the isolator 3 by means of the operating glove 31, and then drives the adjusting screw 72 to rotate, so as to adjust the distance between the pair of guide wheels 7, without polluting the clean environment inside the isolator 3, and the structure is simple and reliable.

[0056] Although the present application has been described in connection with the preferred embodiment thereof with reference to the drawings, it is not to be limited to the details described therein but can be modified in various ways which will be apparent to one of ordinary skill in the art without departing from the scope of the present application as defined by the appended claims.

Claims

1. A feed system for an online cleaning and sterilization freeze dryer of pharmaceutical raw materials, comprising a freeze drying chamber (1), a cleaning and sterilization tank (2), an isolator (3), and a suction gun (4) and a suction gun driving device (5) disposed within the isolator (3), characterized in that: Steam enters the cleaning and sterilization tank (2) to sterilize the suction gun (4). The freeze-drying box (1) and the cleaning and sterilization tank (2) are located on the same side of the isolator (3). The freeze-drying box (1) has a discharge door (11) on the side near the isolator (3). The cleaning and sterilization tank (2) has a cleaning and sterilization door (21) on the side near the isolator (3). The cleaning and sterilization door (21) is equipped with an air-filled sealing ring (29). The suction gun (4) is connected to a discharge pipe assembly (6). The discharge pipe assembly (6) extends to the outside of the isolator (3). The end of the suction gun (4) connected to the discharge pipe assembly (6) is equipped with a sealing seat (41) for sealing the cleaning and sterilization door (21). The other end is inserted between a pair of guide wheels (7), and the pair of guide wheels (7) are connected to an adjustment mechanism (71) for driving the pair of guide wheels (7) to move closer or further apart; the suction gun drive device (5) includes a second drive mechanism (52) for driving the suction gun (4) to enter and exit the discharge door (11) and the cleaning and sterilization door (21), and a third drive mechanism (53) for driving the suction gun (4) to rise and fall. The third drive mechanism (53) includes a lifting drive component (531) and a lifting seat (532) connected to the lifting drive component (531). The second drive mechanism (52) and the guide wheels (7) are located on the lifting seat (532), and the suction gun (4) is located on the second drive mechanism (52).

2. The online cleaning and sterilization raw material freeze dryer discharge system according to claim 1, characterized in that: The adjustment mechanism (71) includes an adjustment screw (72), the two ends of the adjustment screw (72) have opposite spiral directions and are respectively provided with nut seats (73), and a pair of guide wheels (7) are installed on the two nut seats (73) in a one-to-one correspondence.

3. The online cleaning and sterilization raw material freeze dryer discharge system according to claim 2, characterized in that: One end of the adjusting screw (72) is connected to an adjusting handle (74), and the isolator (3) is equipped with an operating glove (31).

4. The online cleaning and sterilization discharge system for a freeze dryer of pharmaceutical raw materials according to any one of claims 1 to 3, characterized in that: The cleaning and sterilization tank (2) includes a tank body (22), a cleaning water inlet (23), a steam inlet (24), and an outlet (25) provided on the tank body (22).

5. The online cleaning and sterilization raw material freeze dryer discharge system according to claim 4, characterized in that: The tank (22) is equipped with a safety valve (26), a pressure sensor (27), and an overflow port (28).

6. The online cleaning and sterilization discharge system for a freeze dryer of pharmaceutical raw materials according to any one of claims 1 to 3, characterized in that: The discharge pipe assembly (6) includes a first rotary joint (61), a first discharge hard pipe (62), a second rotary joint (63), a second discharge hard pipe (64), a third rotary joint (65), and a third discharge hard pipe (66) connected in sequence. The suction gun (4) is connected to the first rotary joint (61), and the third discharge hard pipe (66) extends to the outside of the isolator (3).

7. The online cleaning and sterilization discharge system for a freeze dryer of pharmaceutical raw materials according to any one of claims 1 to 3, characterized in that: The suction gun drive device (5) further includes a first drive mechanism (51) for driving the suction gun (4) to reciprocate between the discharge gate (11) and the cleaning and sterilization gate (21).

8. The online cleaning and sterilization raw material freeze dryer discharge system according to claim 7, characterized in that: The first drive mechanism (51) includes a first guide rail (511), a first slide (512) disposed on the first guide rail (511), and a first drive belt (513) for driving the first slide (512) to reciprocate along the first guide rail (511). The lifting drive member (531) is disposed on the first slide (512). The second drive mechanism (52) includes a second guide rail (521) disposed on the lifting seat (532), a second slide (522) disposed on the second guide rail (521), and a second drive belt (523) for driving the second slide (522) to reciprocate along the second guide rail (521). The suction gun (4) is disposed on the second slide (522), and the second drive belt (523) is disposed on the lifting seat (532).

9. A cleaning and sterilization method for the discharge system of a freeze dryer for raw materials that can be cleaned and sterilized online, as described in any one of claims 1 to 8, characterized in that: Includes the following steps, S1. Raw material discharge: After the raw material is freeze-dried, the discharge door (11) is opened, and the suction gun drive device (5) drives the suction gun (4) to extend into the freeze-drying box (1). The suction gun (4) sucks the raw material on the freeze-dried plate (12) through negative pressure and outputs it to the outside of the isolator (3) through the discharge pipe assembly (6). S2. After the raw materials of each freeze-drying plate (12) are discharged, the suction gun drive device (5) drives the suction gun (4) to exit the freeze-drying box (1), and the discharge door (11) is closed. S3, Suction Gun (4) Online Cleaning and Sterilization: S3.1, The cleaning and sterilization door (21) is opened, and the suction gun drive device (5) drives the suction gun (4) to extend into the cleaning and sterilization tank (2). A pair of guide wheels (7) provide guidance for the suction gun (4) until the sealing seat (41) approaches the pair of guide wheels (7), at which point the suction gun (4) stops. S3.2, The adjusting mechanism (71) increases the distance between a pair of guide wheels (7) until the sealing seat (41) can pass between the pair of guide wheels (7); S3.3, The suction gun drive device (5) drives the suction gun (4) to continue to extend into the cleaning and sterilization tank (2) until the sealing seat (41) and the cleaning and sterilization door (21) are tightly sealed. S3.4 Cleaning and sterilizing tank (2) Cleaning and sterilizing suction gun (4); S4. After the online cleaning and sterilization is completed, the suction gun drive device (5) drives the suction gun (4) to exit the cleaning and sterilization tank (2), the cleaning and sterilization door (21) is closed, and after the sealing seat (41) passes between a pair of guide wheels (7), the adjustment mechanism (71) drives a pair of guide wheels (7) to reset.

10. The cleaning and sterilization method for the discharge system of a freeze dryer capable of online cleaning and sterilization according to claim 9, characterized in that: In step S3.2, the adjusting handle (74) is rotated by operating gloves (31). The adjusting handle (74) drives the adjusting screw (72) to rotate. The nut seats (73) at both ends of the adjusting screw (72) move along the adjusting screw (72) and move away from each other. The distance between a pair of guide wheels (7) increases as the two nut seats (73) move.

Images