Water-in-oil emulsions containing emollients and methods of use thereof

Abstract

In general, the present disclosure relates to compositions comprising at least two or at least three gelling agents, at least one emollient and at least 15% by mass of water relative to the total mass.

Description

[0001] field

[0002] In general, the present disclosure relates to water-in-oil (W / O) emulsion compositions useful in cosmetic products. In particular, the present disclosure describes an improved gelling system for liquid W / O emulsions that allows the composition to contain a higher percentage of water while maintaining desirable properties, such as creamy and smooth texture, excellent coverage and stability, without potential component and phase separation.

[0003] background

[0004] The following discussion is provided merely to aid the reader's understanding of the present disclosure and is not an admission that it describes or constitutes prior art.

[0005] Many currently available non-solid aqueous cosmetics (skin products and color cosmetics) are designed to improve the appearance and feel of human skin. Typically, they contain more than 10% water and moisturizers, and are known to be in the form of emulsions and gels with very low levels (less than 5%) of pigments. Unfortunately for consumers, those products may be very easy to flow and may not provide aesthetics and even coating and coverage. On the other hand, products containing high levels of pigments (higher than 5%) may appear to be sticky and are often unstable (separation and sedimentation occur over time).

[0006] Therefore, there remains a need for a gel-based cosmetic product that will provide long-lasting moisturizing and refreshing benefits, excellent coverage, and minimal product deposition, while being creamy, smooth, and stable. The present disclosure meets this need.

[0007] Brief description

[0008] The present disclosure provides soft, creamy, smooth and / or stable water-in-oil (W / O) emulsion compositions comprising a gelling system and an emollient.

[0009] In one aspect, the present disclosure relates to a W / O emulsion composition comprising at least one gelling system, at least one emollient; and at least 15% by mass of water relative to the total mass of the composition, wherein the at least one gelling system comprises at least one hydrophobic gelling agent and at least one hydrophilic gelling agent.

[0010] In some embodiments, the gelling system further comprises a hydrocarbon gelling agent. For example, in some embodiments, the hydrocarbon gelling agent is a hydrocarbon block copolymer. In some embodiments, the hydrocarbon gelling agent can be selected from ethylene / propylene / styrene copolymers, butene / ethylene / styrene copolymers or mixtures thereof. In some embodiments, the hydrocarbon gelling agent is present in a range of about 4% to about 20% by mass relative to the total mass of the composition.

[0011] In some embodiments, the hydrophilic gelling agent is selected from agar, agarose, carrageenan, gellan gum, alginic acid and mixtures thereof. In some embodiments, the hydrophilic gelling agent is present in a range of about 0.01% to about 1% by mass relative to the total mass of the composition.

[0012] In some embodiments, the hydrophobic gelling agent includes a hydrophobic mineral gelling agent. In some embodiments, the hydrophobic mineral gelling agent is disteardimethylammonium hectorite. In some embodiments, the hydrophobic mineral gelling agent is present in a range of about 1% to about 10% by mass relative to the total mass of the composition. For example, in some embodiments, the hydrophobic mineral gelling agent is about 6% by mass relative to the total mass of the composition.

[0013] In some embodiments, the emollient is a sterol derivative, e.g. In some embodiments, the emollient is present in a range of about 0.5% to about 10% by mass relative to the total mass of the composition. In some embodiments, the emollient is dimer dilinoleate phytosterol / higheralcohol ester.

[0014] In some embodiments, the amount of water is at least 25% by mass relative to the total mass of the composition.

[0015] In some embodiments, the W / O emulsion may further comprise at least one additional ingredient selected from the group consisting of a surfactant, a wax, a solvent, a texturing powder, a wetting agent, a pigment, and a film former.

[0016] In some embodiments, the W / O emulsion is incorporated into a lip composition.

[0017] In another aspect, the present disclosure relates to a method of treating a keratinous surface, the method comprising applying the composition of any of the preceding embodiments to a keratinous surface of a subject. In some embodiments, the keratinous surface may be the lips or skin of a subject (eg, a human subject).

[0018] Also provided herein is a composition according to any of the preceding embodiments for use in treating a keratinous surface of a subject.

[0019] Also provided herein is a composition according to any one of the preceding embodiments for use as a cosmetic product.

[0020] Also provided herein is the use of a composition according to any one of the preceding embodiments for treating a keratinous surface of a subject.

[0021] Also provided herein is the use of a composition according to any one of the preceding embodiments as a cosmetic product.

[0022] The foregoing general description and the following detailed description are exemplary and explanatory and are intended to provide further explanation of the disclosure claimed. Other objects, advantages and novel features will be apparent to those skilled in the art from the following brief description of the drawings and the detailed description of the disclosure.

[0023] Details

[0024] The present disclosure provides a W / O emulsion composition comprising a gelling system and a sterol-based emollient, wherein the gelling system may comprise 2 or 3 or more gelling agents. The disclosed W / O emulsion may be incorporated into a creamy liquid cosmetic to provide a soft, smooth and stable product, and the product may be easily and evenly applied to a user's keratin surface, such as skin or lips.

[0025] Throughout this disclosure, reference may be made to various patent application publications, patents, journal articles, and / or books. No admission is made that these references describe or constitute prior art, but rather are incorporated herein by reference in their entirety.

[0026] I. Definitions

[0027] It should be understood that the method is not limited to the specific embodiments described and can be varied. It should also be understood that the terms used herein are only for the purpose of describing specific embodiments and are not intended to be limiting. The scope of the present technology will be limited only by the appended claims.

[0028] As used herein, certain terms may have the following defined meanings. As used in the specification and claims, the singular forms "a," "an," "the," and the entity itself include both singular and plural referents unless the context clearly dictates otherwise. For example, the term "cell" includes a single cell and a plurality of cells, including mixtures thereof.

[0029] As used herein, "about" refers to the exact stated amount and plus or minus 10%. For example, "about 10" should be understood to mean "10" and "9 to 11".

[0030] As used herein, the term "comprising" is intended to mean that compositions and methods include the described elements, but do not exclude other elements. When used to define compositions and methods, "consisting essentially of..." should mean excluding other elements that are of any importance to the composition or method. "Consisting of..." should mean excluding other ingredients more than trace elements for the claimed compositions and substantial method steps. Embodiments defined by each of these transition terms are within the scope of the present disclosure. Therefore, it is expected that the methods and compositions may include additional steps and components (comprising), or alternatively include insignificant steps and compositions (consisting essentially of), or alternatively refer to only the method steps or compositions (consisting of...).

[0031] As used herein, the terms "individual," "patient," or "subject" can be an individual organism, a vertebrate, a mammal (e.g., bovine, canine, feline, or equine), or a human. These terms are used interchangeably throughout the disclosure. In preferred embodiments, the individual, patient, or subject is a human.

[0032] As used herein, "optionally" means that the subsequently described event or circumstance may or may not occur, and that the description includes instances where said event or circumstance occurs and instances where it does not.

[0033] For descriptive purposes, a phrase in the form “A / B” or in the form “A and / or B” means (A), (B), or (A and B). For descriptive purposes, a phrase in the form “at least one of A, B, and C” means (A), (B), (C), (A and B), (A and C), (B and C), or (A, B, and C).

[0034] The description may use the term "embodiment" or "embodiments," which may each refer to one or more of the same or different embodiments.

[0035] Unless otherwise stated, percentages are by mass (weight) of the composition or the particular phase being described. Unless otherwise stated, all ratios are by mass.

[0036] "Liquid cosmetic" refers to compositions characterized by, but not limited to, a viscosity of less than 150,000 cps, as measured according to the method described below. "Keratinous surface" as used herein refers to skin (including face), hair (including eyelashes and eyebrows) that can be treated with skin and / or makeup products (e.g., color cosmetics).

[0037] As used herein, the term "oil phase" refers to a phase containing a hydrophobic carrier, typically an oily component. Suitable oils include, for example, but not limited to, silicone oils (linear and cyclic), esters, ketones, glycol ethers, vegetable and mineral oils, synthetic oils, paraffin oils, hydrocarbons, aromatic solvents, including but not limited to those identified herein. The oil may be volatile or non-volatile, preferably in the form of a pourable liquid at room temperature (25°C).

[0038] The oil phase may contain additional hydrophobic compounds that are easily incorporated into the hydrophobic vehicle. Such other applicable hydrophobic compounds may be in liquid, solid and / or semisolid form and may include, for example, but are not limited to, oil-soluble waxes and film formers, surfactants, emulsifiers, preservatives, thickeners (gelling agents), emollients, active substances, vitamins, pigments, extracts, powders, hydrophobic solvents and other useful ingredients.

[0039] By "volatile" is meant that the oil has a measurable vapor pressure of at least about 2 mm of mercury at 20°C.

[0040] The term "nonvolatile" means that the oil has a vapor pressure of less than 2 mm of mercury at 20°C.

[0041] The term "hydrophobic" generally refers to a substance that is poorly soluble in water due to its non-polar structure. On the other hand, the term "hydrophilic" refers to a substance that is soluble in water or other polar solvents due to its hydrogen bonding ability.

[0042] Some compounds can possess both hydrophobic and hydrophilic characteristics.

[0043] The term "stable composition" means that the structure of the formulation remains homogeneous and does not separate into different phases.

[0044] The term "aqueous phase" is understood to be a phase containing water as the main carrier. Typically, the aqueous phase may contain additional substances, such as water-soluble film formers, surfactants, emulsifiers, thickeners (gelling agents), emollients, humectants, preservatives, active substances, vitamins, extracts, powders, hydrophilic solvents and other useful ingredients. Those compounds may be introduced into the composition in liquid, solid and / or semisolid form.

[0045] As will be understood by those skilled in the art, for any and all purposes, all ranges disclosed herein also encompass any and all possible subranges and combinations of subranges thereof. Any listed range can be easily considered to be fully described and enables the same range to be decomposed into at least equal halves, thirds, quarters, fifths, tenths, etc. As a non-limiting example, each range discussed herein can be easily decomposed into a lower third, a middle third, and an upper third, etc. As will be understood by those skilled in the art, all languages ​​such as "at most", "at least", "greater than", "less than", etc. include the numbers described and refer to ranges that can be subsequently decomposed into subranges as discussed above. Finally, as will be understood by those skilled in the art, ranges include each individual member. Thus, for example, a group with "1-3 gelling agents" refers to a group with 1, 2, or 3 gelling agents. Similarly, a group with "1-5 gelling agents" refers to a group with 1, 2, 3, 4, or 5 gelling agents, and so on.

[0046] II. Water-in-oil emulsions with gelling system and emollients

[0047] Non-solid aqueous cosmetics containing high levels of water (i.e., greater than 15% by weight) and humectants are known in the art. These known compositions are generally in the form of gels or liquids. These cosmetics with high levels of water may contain pigments, but the compositions are generally unstable, meaning that pigmentation often occurs, and these products do not provide good skin or lip coverage. In addition, known lip products containing about 20% water are not creamy and are generally sticky, heavy, and uncomfortable to use.

[0048] The present disclosure provides a water-in-oil (W / O) emulsion composition comprising a gelling system and at least one emollient. Unlike existing W / O beauty cosmetics and compositions, the disclosed compositions are characterized by a smooth and creamy texture that provides very good coverage with a single application, but at the same time the disclosed compositions are very light / weightless, making their use comfortable all day long. The disclosed compositions are easy to apply and remove without smudging, and the disclosed compositions provide long-term hydration, which prevents the lips and skin from drying out during long-term use. In addition, in contrast to many other products that separate precipitates under conventional storage conditions, the disclosed compositions do not separate over time.

[0049] Despite high water content and textured powder and pigment concentrations, the disclosed compositions remain stable and have great cosmetic staying power.The disclosed W / O emulsions containing emollients can be used in all kinds of color cosmetic and skin product applications.

[0050] The disclosed W / O emulsion composition comprises a gelling system, which preferably comprises two or three gelling agents, including a hydrocarbon gelling agent (e.g. ), a hydrophilic gelling agent (e.g., agar, such as Ina Agar CS-110) and a hydrophobic mineral gelling agent (e.g., Bentone gel). The disclosed W / O emulsion composition further comprises a sterol-based emollient (e.g., ). The combination of more than one gelling agent and emollient allows the disclosed composition to maintain a high water content, for example greater than 15%, while maintaining stability. As described in more detail below and in the Examples section, this combination of components can provide surprising stability, hydration, and comfort, as well as a variety of other beneficial physical and sensory properties.

[0051] In some embodiments, the disclosed W / O emulsion composition comprises: (i) a gelling system comprising at least one hydrocarbon gelling agent, at least one hydrophobic gelling agent, at least one hydrophilic gelling agent; (ii) an emollient; and at least 15% by mass of water relative to the total mass of the composition.

[0052] In some embodiments, the hydrocarbon gelling agent is present in an amount of about 4% to about 20%. In some embodiments, the hydrocarbon gelling agent may include hydrocarbon block copolymers, such as ethylene / propylene / styrene copolymers and / or butene / ethylene / styrene copolymers.

[0053] In some embodiments, the hydrophilic gelling agent is present in an amount of about 0.01% to about 1%. In some embodiments, the hydrophilic gelling agent can be agar.

[0054] In some embodiments, the hydrophobic gelling agent is present in an amount of about 1% to about 10%. In some embodiments, the hydrophobic gelling agent can be bentone / disteardimonium hectorite.

[0055] In some embodiments, the emollient is present in an amount of about 0.5% to about 10%. In some embodiments, the emollient is dibehenyl alcohol / phytosteryl dimer linoleate

[0056] In some embodiments, water is present in an amount of about 15% to about 50%, or about 15% to about 45%, or about 15% to about 40%, or about 15% to about 35%. In some embodiments, the amount of water can be greater than 15%, greater than 16%, greater than 17%, greater than 18%, greater than 19%, greater than 20%, greater than 21%, greater than 22%, greater than 23%, greater than 24%, greater than 25%, greater than 26%, greater than 27%, greater than 28%, greater than 29%, greater than 30%, greater than 31%, greater than 32%, greater than 33%, greater than 34%, or greater than 35%.

[0057] For example, in some embodiments, the disclosed W / O emulsion composition may include about 16% hydrocarbon gelling agent (e.g., ethylene / propylene / styrene copolymer and / or butylene / ethylene / styrene copolymer), about 0.35% hydrophilic gelling agent (e.g., agar), about 6% hydrophobic gelling agent (e.g., bentone / disteardimonium hectorite), about 4% emollient (e.g., dibehenyl alcohol / phytosteryl dimer dimer linoleate), and about 25% water.

[0058] As described in more detail below, various embodiments of the disclosed W / O emulsion compositions comprising at least 15% water, a gelling system, and an emollient provide excellent skin and lip coverage, excellent hydration, and comfort during prolonged use.

[0059] A. Gelation

[0060] The W / O emulsion composition of the present disclosure is characterized by comprising a gelling system comprising at least 2, preferably at least 3 gelling agents. As used herein, "gelling agent" refers to a substance that helps to change the viscosity, thixotropic properties and stability of the cosmetic composition (e.g., reducing pigmentation, syneresis). Therefore, the disclosed gelling system may include, for example, at least one hydrophobic gelling agent and at least one hydrophilic gelling agent. In some embodiments, the gelling system may include a hydrocarbon gelling agent, a hydrophilic gelling agent and a hydrophobic mineral gelling agent.

[0061] In some embodiments, the gelling system ranges from about 1.01% to about 33%, preferably from about 5% to about 25%, and most preferably from about 10% to about 22%, by weight relative to the total mass of the composition. For example, the mass of the gelling system can be about 1%, about 2%, about 3%, about 4%, about 5%, about 6%, about 7%, about 8%, about 9%, about 10%, about 11%, about 12%, about 13%, about 14%, about 15%, about 16%, about 17%, about 18%, about 19%, about 20%, about 21%, about 22%, about 23%, about 24%, about 25%, about 26%, about 27%, about 28%, about 29%, about 30%, about 31%, about 32%, or about 33%, or any value therebetween, relative to the total mass of the composition.

[0062] In some embodiments, the weight ratio of the hydrophobic gelling agent to the hydrophilic gelling agent may be about 1.5:0.005 to about 12.5:1, such as about 6.0:0.35.

[0063] In some embodiments, when at least one hydrocarbon gelling agent such as a hydrophobic styrene copolymer gelling agent is incorporated, the weight ratio of hydrocarbon gelling agent to hydrophobic gelling agent (e.g., hydrophobic mineral gelling agent; bentone / disteardimethylammonium hectorite) is from about 4: 1 to about 2: 1, such as about 8: 3. In some embodiments, the weight ratio of hydrocarbon gelling agent (i.e., styrene copolymer in the carrier) to hydrophilic gelling agent (e.g., agar) to hydrophobic gelling agent (e.g., mineral gelling agent in the carrier) is from about 4: 0.01: 1 to about 2: 0.1: 1, such as about 16: 0.35: 6, respectively.

[0064] i. Hydrocarbon Gelling Agents

[0065] For the purposes of the present disclosure, the gelling system of the disclosed W / O emulsion composition may include at least one hydrocarbon gelling agent. The hydrocarbon gelling agent may include, but is not limited to, ethylene / propylene / styrene copolymers, butene / ethylene / styrene copolymers, or mixtures thereof. In addition to other desired properties, the presence of the hydrocarbon gelling agent results in a desired viscosity of the finished product.

[0066] In some embodiments, the at least one hydrophobic gelling agent can be a hydrocarbon block copolymer. In some embodiments, the hydrocarbon block copolymer comprises at least one styrene block and at least one block comprising units selected from butadiene, ethylene, propylene, butylene and isopropylene, as well as hydrogenated hydrocarbon block copolymers and mixtures thereof. Examples of suitable hydrocarbon-based block copolymers are described in U.S. Patent No. 5,221,534, which is incorporated herein by reference. In some embodiments, hydrocarbon-based block copolymers can be dissolved or dispersed in an oil phase. In some embodiments, hydrocarbon-based block copolymers are amorphous block copolymers of styrene and olefins. In some embodiments, hydrocarbon block copolymers can be styrene copolymer gelling agents, which are selected from but not limited to block polymers comprising at least one block consisting of styrene units or styrene derivatives. The copolymer comprising at least one styrene block can be a diblock or triblock copolymer or a multiblock copolymer (star or radial). Non-limiting examples of such copolymers include ethylene / propylene / styrene copolymers and butylene / ethylene / styrene as described in US Pat. No. 8,021,674 and, for example, in US Pat. No. 6,433,068, all of which are incorporated herein by reference.

[0067] The term "polymer" is intended to refer to copolymers obtained from two types of monomers and copolymers obtained from more than two types of monomers, such as terpolymers obtained from three types of monomers. The molecules of a polymer may contain at least one hydrophilic unit and / or at least one hydrophobic unit.

[0068] One non-limiting exemplary commercially available styrene copolymer gellant that can be used in the disclosed compositions is Versagel ME 2000 (INCI name: Hydrogenated Polyisobutylene (and) Ethylene / Propylene / Styrene Copolymer (and) Butylene / Ethylene / Styrene Copolymer) and other types available from Calumet Penreco as A series of gelling agents for sale. Gelling agents include styrene copolymers in various carriers such as mineral oil, isohexadecane, isododecane, hydrogenated polyisobutane, C12-15 alkyl benzoate and isonolnyl isononanoate.

[0069] In some embodiments, the amount of hydrocarbon gelling agent (i.e., styrene copolymer in the carrier) can be about 4% to about 20%, such as about 6% to about 18%, or about 8% to about 16%, relative to the total mass of the composition by mass. For example, the amount of hydrocarbon gelling agent can be about 4%, about 5%, about 6%, about 7%, about 8%, about 9%, about 10%, about 11%, about 12%, about 13%, about 14%, about 15%, about 16%, about 17%, about 18%, about 19% or about 20%, or any value therebetween, relative to the total mass by mass.

[0070] ii. Hydrophobic mineral gelling agent

[0071] For the purposes of the present disclosure, the gelling system of the disclosed W / O emulsion composition may include at least one hydrophobic gelling agent. The hydrophobic gelling agent may include, but is not limited to, synthetic and / or natural viscosity increasing agents. The presence of the hydrophobic gelling agent may result in a finished product having a desired texture, hardness and / or stability.

[0072] In some embodiments, the at least one hydrophobic gelling agent may be a thickening hydrophobic gelling agent, such as hydrophobic minerals and mixtures thereof.

[0073] The hydrophobic gelling agent is typically incorporated into the oil phase of the disclosed compositions. Suitable hydrophobic gelling agents may be used in the form of a solid or a gel.

[0074] In some embodiments, the at least one hydrophobic gelling agent may include at least one hydrophobic mineral gelling agent. For the purpose of the disclosed composition, useful hydrophobic mineral gelling agents may be selected from, but not limited to, organic modified clays and modified or unmodified hectorites and hydrophobic silica, including fumed silica. Therefore, in some embodiments, the hydrophobic mineral gelling agent may be selected from, for example, dimethyl distearyl ammonium hectorite, dimethyl distearyl ammonium bentonite, and dimethyl distearyl ammonium modified montmorillonite, etc., as described and exemplified in U.S. Patent Publication No. 2007 / 0071703, which is incorporated herein by reference. In some embodiments, the hydrophobic mineral gelling agent may be one in which a quaternary ammonium salt compound is added to a natural or synthetic smectite clay mineral such as bentonite by an ion exchange reaction. The choice of organically modified clay mineral is not particularly limited, as long as it is cosmetically acceptable, and may include, for example, dimethylammonium hectorite, benzyldimethylstearylammonium hectorite, and magnesium aluminum silicate treated with distearyldimethylammonium chloride. In some embodiments, the hydrophobic mineral gelling agent is selected from, for example, bentonite and organically modified hectorite pre-dispersed in an organic solvent. A non-limiting example of commercially available bentonite is BENTONE available from Elementis Specialties. series, including BENTONE ISD V (INCI: Isododecane, Disteardimonium Hectorite, Propylene Carbonate). Another exemplary material is GARAMITE 7308XR available from Eckart (INCI: Quaternium-90 Sepiolite and Quaternium-90 Montmorillonite). In some embodiments, applicable hydrophobic mineral gelling agents include silica, particularly fumed silica and those treated with silanol groups. Such hydrophobic silicas are commercially available, for example, under the trade name Available from Degussa and under the trade name Obtained from Cabot.

[0075] Suitable mineral gelling agents may be used in the form of solid powders or gels wherein the powder is dispersed in a carrier such as mineral oil, isohexadecane, isododecane, hydrogenated polyisobutane, C12-15 alkyl benzoate and / or isononyl isononanoate.

[0076] In some embodiments, the hydrophobic gelling agent is present in an amount of about 1% to about 10%, such as about 2% to about 8%, or about 4% to about 6%, relative to the total mass of the composition by mass. For example, the amount of the hydrophobic gelling agent can be about 1%, about 2%, about 3%, about 4%, about 5%, about 6%, about 7%, about 8%, about 9% or about 10%, or any value therebetween, relative to the total mass by mass.

[0077] iii. Hydrophilic gelling agent

[0078] For the purpose of the present disclosure, the gelling system of the disclosed W / O emulsion composition may include at least one hydrophilic gelling agent. The hydrophilic gelling agent may include, but is not limited to, thermoreversible polysaccharides such as agar, agarose, carrageenan, and gellan gum. In some embodiments, the hydrophilic gelling agent may be incorporated into the formulation in powder form or gel. The presence of a hydrophilic gelling agent allows for optimization of the desired texture and hardness.

[0079] In some embodiments, the at least one hydrophilic gelling agent is agar as described in U.S. Pat. No. 8,933,134, which is incorporated herein by reference. Agar that can be used in exemplary embodiments of the disclosed composition is insoluble in cold water, but can swell significantly, absorbing up to twenty times its own weight in water. It is readily soluble in boiling water, forming a firm gel at a concentration as low as 0.50%. Another useful example is powdered dry agar, which is soluble in water and other solvents at temperatures between 95°C and 100°C. Another useful example is wet agar flocculated with ethanol, 2-propanol or acetone, or wet agar salted out with a high concentration of electrolytes that are soluble in various solvents at room temperature. In some embodiments, the preferred form of agar is a powder; however, agar can also be introduced into the composition as an agar gel, the preparation and characteristics of which are disclosed in U.S. Pat. Nos. 9,757,312 and 8,367,044, all of which are incorporated herein by reference in their entirety. Agar used in conjunction with the disclosed compositions can be cosmetic grade and food grade, including those available from InaFood Industry Corporation.

[0080] The amount of the hydrophilic gelling agent used in the disclosed composition is, but is not limited to, about 0.01% to about 2%, such as about 0.1% to about 1%, or about 0.2% to about 0.5%, relative to the total mass of the composition by mass. In some embodiments, the hydrophilic gelling agent can be mixed with water to obtain a hydrophilic gel. The amount of the at least one hydrophilic gel can be in the range of about 0.01% to about 1%, such as about 0.1% to about 0.9%, or about 0.25% to about 0.5%, relative to the total mass of the composition by mass. For example, the amount of the hydrophilic gelling agent may be about 0.01%, about 0.02%, about 0.03%, about 0.04%, about 0.05%, about 0.06%, about 0.07%, about 0.08%, about 0.09%, about 0.10%, about 0.15%, about 0.20%, about 0.25%, about 0.30%, about 0.35%, about 0.40%, about 0.45%, about 0.50%, about 0.55%, about 0.60%, about 0.65%, about 0.70%, about 0.75%, about 0.80%, about 0.85%, about 0.90%, about 0.95%, about 1.00%, or any value therebetween, by mass, relative to the total mass.

[0081] B. Emollients

[0082] In order to obtain the disclosed compositions containing high levels of water (e.g., above 15%) and provide excellent hydration, comfort, and / or softness / smoothness, the disclosed W / O emulsion compositions may include at least one emollient. For the purposes of the present disclosure, one suitable emollient is a sterol derivative.

[0083] Various emollients that can be added to the disclosed compositions include sterol derivatives, petrolatum, lanolin, mineral oil, and dimethicone. Sterol derivatives are particularly preferred emollients, but those skilled in the art will appreciate that other similar emollients may be substituted.

[0084] Suitable sterol derivatives are phytosterols and cholesterol, such as those described in U.S. Patent Publication No. 2015 / 0202137. Examples of suitable phytosterols include dimerized linoleic acid phytosterol / higher alcohol esters. A wide range of suitable dimerized linoleic acid phytosterol / higher alcohol esters are known under the trade name Available from Nippon Fine Chemical. The product is a lanolin-like paste ester synthesized from plant-based materials. The compounds are characterized by high water holding capacity, high refractive index, high pigment dispersion ability, high oxidative stability, excellent emolliency, excellent gloss and thixotropic flow. The following table records several exemplary Compound.

[0085] Table 1 – Types of Plandool

[0086]

[0087] In some embodiments, the at least one emollient is present in an amount of about 0.5% to about 10%, such as about 2% to about 8%, or about 4% to about 6%, relative to the total mass of the composition by mass. For example, the amount of the emollient can be about 0.5%, about 1%, about 1.5%, about 2%, about 2.5%, about 3%, about 3.5%, about 4%, about 4.5%, about 5%, about 5.5%, about 6%, about 6.5%, about 7%, about 7.5%, about 8%, about 8.5%, about 9%, about 9.5% or about 10% or any value therebetween, relative to the total mass by mass.

[0088] In some embodiments, a particularly useful emollient is dibehenyl alcohol / phytosteryl dimer linoleate, which is present in an amount of about 0.5% to about 10%, for example, about 2% to about 8%, or about 4% to about 6%, by mass relative to the total mass of the composition. For example, the amount of dibehenyl alcohol / phytosteryl dimer linoleate can be about 0.5%, about 1%, about 1.5%, about 2%, about 2.5%, about 3%, about 3.5%, about 4%, about 4.5%, about 5%, about 5.5%, about 6%, about 6.5%, about 7%, about 7.5%, about 8%, about 8.5%, about 9%, about 9.5% or about 10%, or any value therebetween, by mass relative to the total mass.

[0089] C. Water

[0090] The disclosed W / O emulsions require water, and they can be unique in terms of the ability to introduce a large percentage of water while maintaining stability and desired texture (in addition to other desired characteristics). In some embodiments, the disclosed W / O emulsions include about 15% water or are greater than or equal to 15% water. For example, by mass relative to the gross mass of the composition, the amount of water can be about 15% to about 50%, about 15% to about 45%, about 15% to about 40%, about 15% to about 35%, about 15% to about 30%, about 15% to about 25%, about 20% to about 50%, about 20% to about 45%, about 20% to about 40%, about 20% to about 35%, about 20% to about 30%, about 20% to about 25%, about 25% to about 50%, about 25% to about 45%, about 25% to about 40%, about 25% to about 35%, about 25% to about 30% of the scope or any value therebetween. Indeed, in some embodiments, the amount of water in the W / O emulsion can be 15%, 16%, 17%, 18%, 19%, 20%, 21%, 22%, 23%, 24%, 25%, 26%, 27%, 28%, 29%, 30%, 31%, 32%, 33%, 34%, 35%, 36%, 37%, 38%, 39%, 40%, 41%, 42%, 43%, 44%, 45%, 46%, 47%, 48%, 49% or 50% by mass relative to the total mass of the composition, or any value therebetween.

[0091] D. Other ingredients

[0092] The disclosed W / O emulsion compositions may further comprise additional components that render the compositions suitable for use as cosmetic products or for other commercial purposes. The following components may be incorporated into the disclosed compositions comprising a gelling system, an emollient and at least 15% water.

[0093] i. Surfactant system

[0094] The disclosed composition may include at least one surfactant system, which includes, for example, at least one nonionic surfactant having a hydrophilic-lipophilic balance (HLB) value equal to or less than 14. The HLB value is generally related to the emulsifier. In particular, the HLB value relates to the ratio of hydrophilic groups to lipophilic groups in the emulsifier, and relates to the solubility of the emulsifier. Generally, emulsifiers with lower HLB are more soluble in lipophilic substances or oils and are more suitable for W / O emulsions. On the other hand, emulsifiers with higher HLB are more soluble in water or hydrophilic substances and are more suitable for oil-in-water (O / W) emulsions.

[0095] In some embodiments, the disclosed composition may include, for example, a surfactant system comprising a mixture of at least two nonionic surfactants having an HLB value of 2-14. Examples of suitable nonionic surfactants may include polyglycerol alkyl ethers, ester-linked surfactants, polyoxyethylene alkyl ethers, polyglycerol esters, glycerol ethers, sorbitan derivatives (including sorbitan esters), polyethylene glycol derivatives of silicone, polyethylene glycol ethers, alkoxylated alcohols, and carbohydrates. As a further example, suitable surfactants may include, but are not limited to, propylene glycol isostearate, glyceryl stearate, polyglyceryl-3 diisostearate, sorbitan isostearate, oleth-2, lauric acid glyceryl, cetheth-2, methyl glucose sesquistearate, laureth-4, cetearyl glucoside, polysorbate 85, oleth-10, and ceteth-10.

[0096] In some embodiments, the disclosed compositions may include polyethylene glycol derivatives of dimethicone, particularly PEG-8 to PEG-12 dimethicone surfactants and those described in U.S. Pat. No. 7,842,725. In some embodiments, suitable but non-limiting examples of polyethylene glycol derivatives of dimethicone are PEG-12 dimethicone and PEG-10 dimethicone, both of which have an HLB value of less than 14. In some embodiments, the dimethicone surfactant mixture contains PEG-12 dimethicone and PEG-10 dimethicone in a mass ratio of about 5:1 to about 1:1 based on the total mass of the composition.

[0097] In some embodiments, the disclosed compositions can include at least two, at least 3, or at least 4 or more nonionic surfactants.

[0098] The amount of the nonionic surfactant may be, but is not limited to, about 0.01% to about 4%, such as about 0.1% to about 3%, or about 0.2% to about 2.5%, relative to the total mass of the composition by mass. The amount of the stearyl glyceryl surfactant may be, but is not limited to, about 0.01% to about 4%, such as about 0.1% to about 3%, or about 0.2% to about 2.5%, relative to the total mass of the composition by mass.

[0099] The amount of PEG-12 dimethicone may range from, but is not limited to, about 0.01% to about 4%, such as about 0.1% to about 3%, or about 0.2% to about 2.5% by mass relative to the total mass of the composition.

[0100] The amount of PEG-10 dimethicone may range from, but is not limited to, about 0.01% to about 4%, such as about 0.1% to about 3%, or about 0.2% to about 2.5% by mass relative to the total mass of the composition.

[0101] ii. Wax

[0102] In some embodiments, the disclosed composition may include at least one wax. The at least one wax may be selected from, but is not limited to, waxes that are solid or semisolid at room temperature (25°C). Specific examples include, but are not limited to, natural and synthetic waxes, such as beeswax, candelilla wax, cotton wax, carnauba wax, bayberry wax, insect wax (wax secreted by Ericeruspela), spermaceti, montan wax, bran wax (rice wax), capok wax, Japan wax, acetic lanolin, liquid lanolin, sugarcane wax, esters of lanolin fatty acids and isopropyl alcohol, hexyl laurate, reduced lanolin, jojoba wax, hard lanolin, lac wax, beeswax, microcrystalline wax, paraffin, POE lanolin alcohol ether, POE lanolin alcohol acetate, POE cholesterol ether, esters of lanolin fatty acids and polyethylene wax, synthetic waxes, fatty acid glycerides, hydrogenated castor oil, vaseline, and POE hydrogenated lanolin alcohol ether.

[0103] The amount of the wax may range from, but is not limited to, about 2% to about 10%, such as about 2.5% to about 8%, or about 3% to about 6% by mass relative to the total mass of the composition.

[0104] iii.Solvent

[0105] In some embodiments, the disclosed compositions may include at least one solvent. The at least one solvent may be selected from, but not limited to, solvents having a flash point below 50°C and those having a flash point above 70°C, including volatile and non-volatile hydrocarbons, volatile and non-volatile silicones, alcohols, glycols, esters, vegetable oils, and synthetic oils. Some exemplary solvents include hydrocarbon- and silicone-based solvents, such as hydrogenated polyisobutane, isododecane, dimethicone, and semethicone. A commercially available suitable hydrocarbon solvent is PARLEM 4 (INCI name: hydrogenated polyisobutane and tocopherol), available from NOF Corporation.

[0106] The amount of the solvent may range from, but is not limited to, about 0.01% to about 30%, such as about 0.1% to about 25%, or about 1% to about 20% by mass relative to the total mass of the composition.

[0107] iv.Textured powder

[0108] In some embodiments, the disclosed compositions may include at least one texturing powder. The at least one texturing powder may be selected from, but not limited to, minerals and organic fillers of any shape. For example, the texturing powder may be, but not limited to, a mixture of silica, polymer microspheres, and amino acids. Examples include, but are not limited to, mica, silica, polyamide powder, starch, boron nitrate, silicone resin microspheres, and elastomer powders.

[0109] The amount of texturizing powder may range from, but is not limited to, about 0.01% to about 30%, such as about 0.1% to about 25%, or about 1% to about 20% by mass relative to the total mass of the composition.

[0110] v. Moisturizer

[0111] Humectants, including glycerin, lecithin, and propylene glycol, draw water into the outer layer of the skin. In some embodiments, the disclosed compositions may include one or more humectants selected from, but not limited to, hydrophilic humectants, including polyol-type humectants such as dipropylene glycol, polyglycerol, 1,3-butylene glycol, ethers, polyols, glycerin, glycerin polymers, and polyethylene glycols, as described in U.S. Pat. No. 5,977,188. In some embodiments, glycerin and glycerin polymers having up to 40 glycerin units are incorporated into the disclosed compositions as humectants.

[0112] The amount of the moisturizer is, but not limited to, in the range of about 0.01% to about 5%, such as about 0.1% to about 3%, or about 0.2% to about 1% by mass relative to the total mass of the composition.

[0113] vi. Pigment

[0114] In some embodiments, the disclosed compositions may include at least one pigment selected from, but not limited to, organic and inorganic processed pigments and pigments such as those providing special visual effects. Specific examples of suitable pigments include, but are not limited to, iron oxides, red 7 lakes, and gonioichromatic pigments.

[0115] The amount of the pigment may range from, but is not limited to, about 0.01% to about 30%, such as about 0.1% to about 25%, or about 1% to about 20% by mass relative to the total mass of the composition.

[0116] vii. Film former

[0117] In some embodiments, the disclosed compositions may include at least one film former selected from, but not limited to, water-soluble film formers and oil-soluble film formers, acrylic-based film formers, silicone-based film formers, such as those described in US 2009 / 001708.

[0118] As used herein, "film former" or "film-forming polymer" refers to a polymer or resin that leaves a film on a substrate to which it is applied, for example after a solvent associated with the film former has evaporated, absorbed into the substrate, and / or dissipated on the substrate.

[0119] The amount of the film former may be, but is not limited to, about 0.01% to about 30%, more preferably about 0.1% to about 25%, and most preferably about 1% to about 20% by mass relative to the total mass of the composition.

[0120] The disclosed compositions may also contain other components suitable for their intended use, such as organic pigments, preservatives, fillers, active substances, sunscreens, additives and / or additional solvents.

[0121] III. Preparation method of the disclosed W / O emulsion containing an emollient

[0122] The disclosed composition can be prepared by mixing an emollient (e.g. ), wax and at least one solvent (e.g. Parleam-4 and Vegelight C912-LC) are mixed together until a homogeneous mixture is formed. Other hydrophobic components may be added and the mixture may be homogenized and still heated at 90°C. All ingredients of the aqueous phase may be mixed in a separate container and heated to 70-80°C until a clear homogeneous solution is obtained. The aqueous phase may then be added to the rest of the composition and mixed at 90°C for about 10 minutes or until a smooth, creamy texture is obtained. The finished composition is filled into suitable compartments.

[0123] IV. Methods of using the disclosed W / O emulsions containing emollients

[0124] Disclosed herein is a method for using the disclosed W / O emulsion composition, which comprises a gelling system, at least one emollient and at least 15% water. In particular, the composition can be used to treat keratin surfaces, such as lips or skin. The method includes applying the disclosed composition to a keratin surface to provide color, hydration and / or smoothness to the keratin surface. In other words, the present disclosure provides a method for using the disclosed composition as a beauty cosmetic. In some embodiments, the disclosed composition can be applied in the form of a lip gloss, a liquid lip liner or a lip gloss. In some embodiments, the composition can be, but is not limited to, a lip product, a foundation, a blush, an eye shadow, a mascara, an eyeliner, a skin care product, a sunscreen product, etc. The disclosed composition can be used in various applicable applicators and containers, such as cans, pens, pencils, brushes, etc.

[0125] Also provided herein is a disclosed liquid W / O emulsion composition for use as a cosmetic product or for application to keratin surfaces, comprising a gelling system, at least one emollient and at least 15% water.

[0126] Also provided herein is the use of the disclosed liquid W / O emulsion composition for treating keratin surfaces or as a cosmetic product, the composition comprising a gelling system, at least one emollient and at least 15% of water. Example

[0127] The following examples are given to illustrate the present disclosure. It should be understood, however, that the disclosure is not to be limited to the specific conditions or details described in these examples.

[0128] Example 1 - Preparation of an Exemplary W / O Emulsion Containing an Emollient

[0129] The following examples describe exemplary methods of preparing embodiments of the disclosed W / O emulsion compositions comprising an emollient. Table 2 below lists the components used.

[0130] Table 2 - Exemplary composition components

[0131]

[0132] Compound A was combined in the main container and heated at 90°C until a homogenous mixture was formed. Compounds B, C, D, E, F and G were then added and homogenized using Robomics (supplied by Tokushu Kika) at 4000 RPM for 2 minutes while still heating at 90°C.

[0133] Meanwhile, in a small vessel, combine all ingredients of the aqueous phase (H) and heat at 70-80°C until a clear and homogeneous mixture is obtained.

[0134] The water phase was then added to the mixture in the main container and mixed together for a further 10 minutes at 90°C until a smooth and creamy texture was obtained.

[0135] Example 2 - Determination of the quality of W / O emulsions containing emollients

[0136] The following examples were used to determine the effects of each component of the gelling system and the emollient on the physical properties of the resulting composition. Thus, a composition containing three gelling agents (i.e., a hydrophobic gelling agent, a hydrophilic gelling agent, and a hydrocarbon gelling agent) and an emollient was prepared as an exemplary W / O emulsion, and four controls were prepared, each lacking one of the components of the gelling agent or the emollient. Table 3 below discloses the components and component concentrations of each of these compositions.

[0137] Table 3 - Components of Exemplary and Comparative Compositions

[0138]

[0139]

[0140] Once the exemplary compositions and controls were prepared, they were subjected to a battery of tests to evaluate their physical properties, including texture, viscosity, emulsion stability, and storage stability.

[0141] Texture was analyzed by two (2) liquid lip makeup users immediately after applying the exemplary compositions and the control. The samples were evaluated for duration after application (i.e., how long it lasted), lightness (weight), freshness and lightness, smoothness, creaminess, coverage, and comfort.

[0142] Viscosity was measured using a Brookfield Viscometer Model RV with a TD spindle at a speed of 12 RPM at 25°C / 35% RM.

[0143] For the evaluation of emulsion stability, samples were visually inspected for separation immediately after preparation.

[0144] For evaluation of storage stability, samples were visually inspected for separation after two (2) weeks of exposure at the following temperatures: -5°C, 0°C, 25°C, 37°C, 45°C, and 37°C / 98% RH (relative humidity). Table 3 shows the results of each of these evaluations.

[0145] Table 4 - Comparison of physical properties of various compositions

[0146]

[0147] As can be seen from Table 3 above, the W / O emulsion characterized by the most desirable texture as well as acceptable viscosity and stability is a triple gel and emollient. These results indicate that three gelling agents and emollients are required to obtain the best possible results.

[0148] Example 3 - Comparison of W / O Emulsions Containing Emollients with Other Liquid Lip Products

[0149] To demonstrate the superior qualities of the disclosed triple gel and emollient composition (e.g., ease of application and removal, coverage, weight, comfort, tack, shine, scent, etc.), the exemplary triple gel and emollient composition from Example 2 was compared to several commercially available products having high water content (i.e., all products were above 15% except Comparative Product 3, as shown below).

[0150] Comparative product 1 is a vinyl lip gloss containing water, octyldodecanol, trimethylsiloxyphenyl dimethicone, ethylcellulose, synthetic wax, cetyl alcohol, alcohol, polybutene, glyceryl stearate, behenyl alcohol, steareth-20, phenoxyethanol, sodium lauryl sulfate, glyceryl stearate citrate, disodiumethylene dicocamide PEG-15 disulfate, hydroxypropyl guar gum, calcium aluminum borosilicate, synthetic fluorphlogopite, stearyl alcohol, myristyl alcohol, magnesium silicate, calcium sodium borosilicate, aluminum hydroxide, sodium saccharin, alumina, benzyl alcohol, silica, tin oxide, anise alcohol, fragrance and color.

[0151] Comparative product 2 is a lipstick, which contains water, octyldodecanol, cyclopentasiloxane, hydrogenated polyisobutene, pentaerythrityl tetraisostearate, ethylcellulose, glycerin, alcohol, polyglyceryl-2 triisostearate, isododecane, polyglyceryl-6 polyricinoleate, pentylene glycol, polyglyceryl-2 isostearate, phenoxyethanol, disteardimonium hectorite, lecithin, butylene / ethylene / styrene copolymer, ethylene / propylene / styrene copolymer, trimethylolpropane triisostearate, Chondrus crispus (carrageenan), sodium chloride, BHT, fragrance (fragrance), diisostearyl malate, polyglyceryl-3 polyricinoleate, stevioside, synthetic fluorphlogopite, benzyl salicylate, linalool, tocopherol, amyl cinnamaldehyde, propyl gallate and pigment.

[0152] Comparative product 3 is a lip gloss, which contains water, octyldodecanol, trimethylsiloxysilicate, cyclopentasiloxane, alcohol, sorbitan sesquioleate, polyglyceryl-2 triisostearate, dimer dimer dimer dimer linoleate, caprylic / capric triglyceride, propylene glycol, polysorbate 80, ethylcellulose, polyacrylamide, C13-14 isoparaffin, laureth-7, 1,2-hexanediol, phenoxyethanol, Rosa canina fruit oil, avocado oil, Prunus armeniaca kernel oil, Macadamia ternifolia seed oil, tocopheryl acetate, fragrance and pigment.

[0153] Comparative product 4 is a lipstick, which contains water, glycerin, butylene glycol, ethylhexyl stearate, alcohol, hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, vinyl polydimethylsiloxane / polymethicone silsesquioxane crosspolymer, squalane, Phyllostachis bambusoides extract, phenoxyethanol, polyglyceryl-2 triisostearate, PEG-60 hydrogenated castor oil, lecithin, trimethylolpropane triisostearate, polysorbate 60, vanillin, fragrance (fragrance), sodium citrate, sorbitan isostearate, stevioside, PEG-7 cocoyl glyceryl, citric acid, polyquaternium-7, propyl gallate, benzyl alcohol, BHT, methylsilanol tri-PEG-8 glyceryl cocoate and pigment.

[0154] The exemplary W / O emulsion with emollient composition and the comparative product were compared by application by four (4) regular users of liquid lip makeup products aged 24-55 years. The individuals applied the exemplary composition and each comparative product and evaluated their various parameters as listed in Table 4 below. Depending on the type of problem, some evaluations were performed immediately after application and other evaluations were performed one (1) hour after application of each product. The evaluation of each product was performed on different days, with one product randomly selected each day.

[0155] Table 5 - Sensory Comparison of Exemplary and Competitive Compositions

[0156]

[0157] As shown in the table above, the triple gel plus emollient performed better in every sensory evaluation compared to the comparative product. In particular, the disclosed triple gel plus emollient composition was easy to remove (i.e., did not stain), was not sticky or heavy, had no odor, and was comfortable to use all day.

[0158] *****

[0159] The present technology is not limited to the specific embodiments described in this application, and these embodiments are intended to be a single description of various aspects of the present technology. As is apparent to those skilled in the art, various modifications and changes can be made to the present technology without departing from its purpose and scope. In addition to those listed herein, the functionally equivalent methods and devices of the scope of the present technology will be apparent to those skilled in the art according to the foregoing description. Such modifications and changes are intended to fall within the scope of the present technology. It should be understood that the present technology is not limited to specific methods, reagents, compounds, compositions or biological systems, which can certainly be changed. It should also be understood that the terms used herein are only for the purpose of describing specific embodiments, rather than being intended to limit.

[0160] Those skilled in the art will readily appreciate that the present disclosure is well suited for carrying out the stated objectives and obtaining the results and advantages mentioned and those inherent therein. Those skilled in the art will appreciate variations and other uses thereof. These variations are encompassed within the spirit of the present disclosure and are limited by the scope of the claims setting forth non-limiting embodiments of the present disclosure.

[0161] In addition, where features or aspects of the disclosure are described in terms of Markush groups, those skilled in the art will recognize that the disclosure is also thereby described in terms of any individual member or group of members of the Markush group.

Claims

1. A W / O emulsion composition comprising at least one gelling system, at least one emollient; and at least 15% by mass of water relative to the total mass of the composition, wherein the at least one gelling system comprises at least one hydrophobic gelling agent, at least one hydrophilic gelling agent and at least one hydrocarbon gelling agent, wherein the hydrophobic gelling agent comprises a hydrophobic mineral gelling agent; and The emollient is a sterol derivative.

2. The W / O emulsion composition according to claim 1, wherein the hydrocarbon gelling agent is a hydrocarbon block copolymer.

3. The W / O emulsion composition according to claim 1 or 2, wherein the hydrocarbon gellant is selected from ethylene / propylene / styrene copolymers, butene / ethylene / styrene copolymers or mixtures thereof.

4. The W / O emulsion composition according to any one of claims 1 to 3, wherein the hydrocarbon gelling agent is present in a range of 4% to 20% by mass relative to the total mass of the composition.

5. The W / O emulsion composition according to any one of claims 1 to 4, wherein the hydrophilic gelling agent is selected from the group consisting of agar, agarose, carrageenan, gellan gum, alginic acid and mixtures thereof.

6. The W / O emulsion composition according to any one of claims 1 to 5, wherein the hydrophilic gelling agent is present in the range of 0.01% to 1% by mass relative to the total mass of the composition.

7. The W / O emulsion composition according to any one of claims 1 to 6, wherein the hydrophobic gelling agent is disteardimethylammonium hectorite.

8. The W / O emulsion composition according to any one of claims 1 to 7, wherein the hydrophobic gelling agent is present in the range of 1% to 10% by mass relative to the total mass of the composition.

9. The W / O emulsion composition of claim 8, wherein the hydrophobic gelling agent is about 6% by mass relative to the total mass of the composition.

10. The W / O emulsion composition according to any one of claims 1 to 9, wherein the emollient is present in a range of 0.5 to 10% by mass relative to the total mass of the composition.

11. The W / O emulsion composition according to any one of claims 1 to 10, wherein the emollient is phytosterol dimer linoleate / higher alcohol ester.

12. The W / O emulsion composition according to any one of claims 1 to 11, wherein the amount of water is at least 25% by mass relative to the total mass of the composition.

13. The W / O emulsion composition of any one of claims 1 to 12, further comprising at least one surfactant, wax, solvent, texturizing powder, moisturizer, pigment or film former.

14. The W / O emulsion composition according to any one of claims 1 to 13, wherein the W / O emulsion composition is incorporated into a lip composition.

15. A method of treating a keratinous surface, the method comprising applying the composition of any one of claims 1 to 14 to a keratinous surface of a subject.

16. The method of claim 15, wherein the keratin surface is the lips or skin of a subject.

17. A composition according to any one of claims 1 to 14 for use in treating a keratinous surface of a subject.

18. A composition according to any one of claims 1 to 14 for use as a cosmetic product.

19. Use of a composition according to any one of claims 1 to 14 for treating keratinous surfaces of a subject.

20. Use of a composition according to any one of claims 1 to 14 as a cosmetic product.

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