Analysis method of hyssopus officinalis volatile oil and application of hyssopus officinalis volatile oil in preparation of medicine for treating hormone-resistant asthma

A technology of hormone resistance and analysis method, which is applied in the analysis of the volatile oil of the herb, and in the application field of preparation of drugs for the treatment of hormone-resistant asthma. The number of inflammatory cells, reducing the area of ​​infiltration, reducing the effect of hyperplasia and

CN114177216AActive Publication Date: 2022-03-15HUAZHONG UNIV OF SCI & TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Publication Date
2022-03-15

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Abstract

The invention relates to an analysis method of hyssopus officinalis volatile oil and application of the hyssopus officinalis volatile oil in preparation of a medicine for treating hormone-resistant asthma, which comprises qualitative and relative quantitative analysis of chemical components of the hyssopus officinalis volatile oil, construction of a hormone-resistant asthma model and grouped administration. The influence of the hyssopus officinalis volatile oil on the number of inflammatory cells in alveolar lavage fluid and peripheral blood of a mouse with the hormone-resistant asthma is researched, and the influence of the hyssopus officinalis volatile oil on the concentration of interleukin-17 (IL-17) and granulocyte colony stimulating factor (G-CSF) in BALF and lung tissues of the mouse with the hormone-resistant asthma is researched. The influence of the hyssopus officinalis volatile oil on pathological changes of lung tissues of mice with hormone-resistant asthma is studied, and the chemical components of the hyssopus officinalis volatile oil and the pharmacological action of the hyssopus officinalis volatile oil for treating the hormone-resistant asthma are integrally evaluated according to the studies. The hyssopus officinalis volatile oil has great significance in new drug research and clinical application of the hyssopus officinalis volatile oil for treating the hormone-resistant asthma.
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Description

technical field

[0001] The invention belongs to the field of medicine, and more specifically, relates to an analysis method of the volatile oil of the herb elixir and its application in the preparation of a medicine for treating steroid-resistant asthma. Background technique

[0002] Steroid-resistant asthma (SRA) refers to asthma that is ineffective or ineffective in treatment with oral glucocorticoids (GC). So far, the pathogenesis of SRA is still not fully understood. The proven mechanism of GC resistance effect includes: glucocorticoid receptor (glucocorticoid receptor, GR, GRα and GRβ are the two main subtypes of GR) abnormality, imbalance of immune regulation mechanism, abnormal activity of histone acetylase, Abnormal heat shock protein HSP90, transcription factor AP-1 and NF-κB abnormalities, etc.

[0003] GR abnormality mainly manifests as increased GRβ expression, decreased GC-GRα affinity, abnormal GRα nuclear translocation, and GR phosphorylation. Among them, G...

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Embodiment Construction

[0030] In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention. In addition, the technical features involved in the various embodiments of the present invention described below can be combined with each other as long as they do not constitute a conflict with each other.

[0031]The present invention provides a method for analyzing the volatile oil of Herba Herbs and its application in the preparation of medicaments for treating steroid-resistant asthma, comprising the following steps:

[0032] Step 1: Qualitative and Relative Quantitative Analysis of the Chemical Components of the Essential Oil of Herba Sinensis

[0033] Take the dried above ground part of the h...