A method of making an alcohol-based leave-on gel

Abstract

The application provides a preparation method of alcohol non-washing gel, which comprises the following steps: heating, stirring and dissolving thickening agent, humectant and water; homogenizing; cooling and reducing temperature; slowly and uniformly adding ethanol under stirring; adding pH regulator to adjust the pH of the system to 5.5-6.5; adding water to make up the weight; and stirring uniformly to obtain the product. The preparation method is simple and convenient to use, and the formula does not contain essence and pigment, and can effectively inhibit and remove bacteria. Meanwhile, the alcohol non-washing gel prepared by the method is not sticky, can be rapidly air-dried, has high transparency and good stability.

Description

Technical Field

[0001] This invention belongs to the field of no-rinse gel technology, specifically relating to a method for preparing an alcohol-based no-rinse gel. Background Technology

[0002] Various microorganisms exist in nature. Especially in summer and during peak seasons for germs, bacteria multiply rapidly. Some microorganisms can enter the body and have a significant impact on the internal environment, even causing various infectious diseases.

[0003] Ethanol, commonly known as alcohol, is a frequently used disinfectant with strong bactericidal and bacteriostatic properties. It can coagulate proteins and cause pathogens to die. In medicine, 70%–75% ethanol is commonly used as a disinfectant. This is mainly because excessively high concentrations of alcohol will form a protective film on the surface of bacteria, preventing them from penetrating and thus making it difficult to completely kill the bacteria. If the alcohol concentration is too low, although it can penetrate the bacteria, it cannot coagulate the proteins inside, also failing to kill the bacteria completely. Therefore, using 70%–75% alcohol ensures that the proteins composing the bacteria coagulate without forming a membrane, allowing the alcohol to continue penetrating and achieving thorough disinfection.

[0004] With societal development, people are increasingly valuing health and have begun using various disinfection products to sterilize food, their bodies, and clothing. However, most of these products require rinsing with water, which is inconvenient for areas with limited water resources or for people who travel frequently. Therefore, a series of hand sanitizers have gradually emerged, among which hand sanitizer gels are particularly popular. The most significant feature of alcohol-based hand sanitizer gels is that they effectively inhibit and remove bacteria from the hands without requiring rinsing with water.

[0005] However, a series of problems easily arise during the preparation of high-concentration alcohol-based no-rinse gels, such as poor product transparency and the appearance of white flocculent substances during preparation or stabilization, thus affecting product quality. The main objective of this invention is to solve the above problems and prepare an alcohol-based no-rinse gel with high transparency and excellent stability. Summary of the Invention

[0006] The purpose of this invention is to provide a method for preparing an alcohol-based no-rinse gel with high transparency and good stability. This method is simple, easy to use, and the formula does not contain fragrances or pigments. It can effectively inhibit and eliminate bacteria.

[0007] This invention is achieved through the following technical solution:

[0008] On the one hand, the present invention provides a method for preparing an alcohol-based no-rinse gel, wherein ethanol is added slowly and uniformly in the preparation method, and the total time for the addition of ethanol is 2 to 20 minutes, preferably 3 to 10 minutes.

[0009] In some embodiments, the total time for the addition of ethanol is 2 to 20 minutes.

[0010] In some embodiments, the total time for the addition of ethanol is 3 to 10 minutes.

[0011] In some embodiments, a method for preparing an alcohol-based no-rinse gel specifically includes the following steps:

[0012] (a) Heat the thickener, humectant and water to 80-85°C, stir to dissolve and keep warm for 10-15 minutes;

[0013] (b) Start the homogenizer, homogenize at a speed of 1000-1500 r / min, and homogenize for 2-5 min;

[0014] (c) Turn on the cooling and cooling. When the temperature drops to 41-46°C, slowly and uniformly add the ethanol while stirring. The ethanol should not be added too quickly, otherwise white flocculent substances may appear, resulting in poor product stability.

[0015] (d) Continue stirring, add pH adjuster while stirring, adjust the pH of the system to between 5.5 and 6.5, add water to make up to 100 parts of total weight, stir evenly to obtain a transparent alcohol-based no-rinse gel with a certain viscosity.

[0016] In some embodiments, the concentration of ethanol is greater than 95%.

[0017] In some embodiments, the pH adjuster is provided in a water-soluble form. When the pH adjuster is provided in a water-soluble form, neutralization of the thickener does not result in a localized, instantaneous increase in concentration, and the alcohol-based no-rinse gel prepared in combination with other components exhibits superior stability and transparency.

[0018] In some embodiments, the weight ratio of the pH adjuster to water is 1:5 to 1:10.

[0019] On the other hand, the present invention provides an alcohol-based no-rinse gel prepared according to the above preparation method, wherein the proportions of the raw materials are as follows: per 100 parts by weight, there are 3.0 to 8.0 parts of humectant, 0.3 to 0.6 parts of thickener, 65 to 75 parts of ethanol, an appropriate amount of pH adjuster, and the balance being water.

[0020] In some embodiments, the proportions of the raw materials are as follows: per 100 parts by weight, there are 4.0 to 6.0 parts of humectant, 0.35 to 0.55 parts of thickener, 68 to 73 parts of ethanol, an appropriate amount of pH adjuster, and the remainder water.

[0021] In some embodiments, the moisturizer includes glycerin or butylene glycol.

[0022] In some embodiments, the thickener comprises one or more of the carbomer class.

[0023] In some embodiments, the thickener is one or a combination of Carbopol Ultrez 20, Carbopol Ultrez 21, and Carbopol 980.

[0024] In some embodiments, the pH adjuster includes triethanolamine or tromethamine.

[0025] The beneficial effects of this invention are as follows:

[0026] (1) The formula of this invention does not contain fragrances or pigments and can be used for hand disinfection by a variety of people, such as those engaged in food and other processing industries.

[0027] (2) The alcohol-based hand sanitizer gel of the present invention does not require rinsing with water, is easy to use, and can effectively inhibit and remove bacteria on the hands, making it easy for consumers to accept.

[0028] (3) The preparation method of the present invention is simple, and the prepared alcohol no-wash gel has high transparency and good stability.

[0029] (4) The product formula is non-sticky, dries quickly, and contains moisturizing ingredients to keep the skin of your hands comfortable and refreshed.

[0030] Detailed description

[0031] On the one hand, the present invention provides a method for preparing an alcohol-based no-rinse gel, wherein ethanol is added slowly and uniformly in the preparation method, and the total time for the addition of ethanol is 2 to 20 minutes, preferably 3 to 10 minutes.

[0032] In some embodiments, the total time for the addition of ethanol is 2 to 20 minutes.

[0033] In some embodiments, the total time for the addition of ethanol is 3 to 10 minutes.

[0034] In some embodiments, a method for preparing an alcohol-based no-rinse gel specifically includes the following steps:

[0035] (a) Heat the thickener, humectant and water to 80-85°C, stir to dissolve and keep warm for 10-15 minutes;

[0036] (b) Start the homogenizer, homogenize at a speed of 1000-1500 r / min, and homogenize for 2-5 min;

[0037] (c) Turn on the cooling and cooling. When the temperature drops to 41-46°C, slowly and uniformly add the ethanol while stirring. The ethanol should not be added too quickly, otherwise white flocculent substances may appear, resulting in poor product stability.

[0038] (d) Continue stirring, add pH adjuster while stirring, adjust the pH of the system to between 5.5 and 6.5, add water to make up to 100 parts of total weight, stir evenly to obtain a transparent alcohol-based no-rinse gel with a certain viscosity.

[0039] In some embodiments, the concentration of ethanol is greater than 95%.

[0040] In some embodiments, the pH adjuster is provided in a water-soluble form. When the pH adjuster is provided in a water-soluble form, neutralization of the thickener does not result in a localized, instantaneous increase in concentration, and the alcohol-based no-rinse gel prepared in combination with other components exhibits superior stability and transparency.

[0041] In some embodiments, the weight ratio of the pH adjuster to water is 1:5 to 1:10.

[0042] In some embodiments, the weight ratio of the pH adjuster to water is 1:5.

[0043] In some embodiments, the weight ratio of the pH adjuster to water is 1:8.

[0044] In some embodiments, the weight ratio of the pH adjuster to water is 1:10.

[0045] On the other hand, the present invention provides an alcohol-based no-rinse gel prepared according to the above preparation method, wherein the proportions of the raw materials are as follows: per 100 parts by weight, there are 3.0 to 8.0 parts of humectant, 0.3 to 0.6 parts of thickener, 65 to 75 parts of ethanol, an appropriate amount of pH adjuster, and the balance being water.

[0046] In some embodiments, the proportions of the raw materials are as follows: per 100 parts by weight, there are 4.0 to 6.0 parts of humectant, 0.35 to 0.55 parts of thickener, 68 to 73 parts of ethanol, an appropriate amount of pH adjuster, and the remainder water.

[0047] In some embodiments, the proportions of the raw materials are as follows: per 100 parts by weight, there are 4.0 parts of humectant, 0.40 parts of thickener, 73 parts of ethanol, 1.6 parts of pH adjuster in an aqueous solution (wherein the pH adjuster is in a weight ratio of 1:10 to water) and the remainder is water.

[0048] In some embodiments, the proportions of the raw materials are as follows: per 100 parts by weight, there are 5.0 parts of humectant, 0.55 parts of thickener, 68 parts of ethanol, 1.5 parts of pH adjuster in an aqueous solution (wherein the pH adjuster is in a weight ratio of 1:8 to water) and the remainder is water.

[0049] In some embodiments, the proportions of the raw materials are as follows: per 100 parts by weight, there are 6.0 parts of humectant, 0.35 parts of thickener, 70 parts of ethanol, 0.9 parts of pH adjuster in an aqueous solution (wherein the pH adjuster is in a weight ratio of 1:5 to water) and the remainder is water.

[0050] In some embodiments, the moisturizer includes glycerin or butylene glycol.

[0051] In some embodiments, the thickener comprises one or more of the carbomer class.

[0052] In some embodiments, the thickener is one or a combination of Carbopol Ultrez 20, Carbopol Ultrez 21, and Carbopol 980.

[0053] In some embodiments, the pH adjuster includes triethanolamine or tromethamine. Detailed Implementation

[0054] Embodiments of the present invention are described in detail below. These embodiments are exemplary and intended to explain the present invention, and should not be construed as limiting the invention.

[0055] The present invention will be further explained and described below with reference to specific embodiments.

[0056] Example 1

[0057] This embodiment presents an alcohol-based no-rinse gel with high transparency and good stability, prepared from the following raw materials in parts by weight, as shown in Table 1:

[0058] Table 1:

[0059]

[0060]

[0061] Specific operation method:

[0062] Weigh 0.35 parts thickener, 6.0 parts glycerin, and water, heat to 80℃ for sterilization, and stir to dissolve. Start homogenization at 1000 r / min for 5 min. Start cooling and when the temperature drops to 41℃, slowly and evenly add ethanol to the system while stirring. The ethanol should not be added too quickly. The addition of ethanol should be completed in 3.5 min. After stirring evenly, add the pH adjuster that has been dissolved in water in advance to adjust the pH value and control the pH of the system to 6.0. After stirring evenly, a transparent alcohol-based no-wash gel with a certain viscosity is obtained.

[0063] Example 2

[0064] This embodiment presents an alcohol-based no-rinse gel with high transparency and good stability, prepared from the following raw materials in parts by weight, as shown in Table 2:

[0065] Table 2:

[0066] raw material Proportion (%) glycerin 4.0 Thickener 0.40 water 21 ethanol 73 pH adjuster 1:10 aqueous solution 1.6

[0067] Specific operation method:

[0068] Weigh 0.40 parts thickener, 4.0 parts glycerin, and water, heat to 85℃ for sterilization, and stir to dissolve. Start homogenization at 1200 r / min for 3 min. Start cooling and when the temperature drops to 42℃, slowly and evenly add ethanol to the system while stirring. The ethanol should not be added too quickly, and the addition of ethanol should be completed in 4 min. After stirring evenly, add the pH adjuster that has been dissolved in water in advance to adjust the pH value and control the pH of the system to 5.5. After stirring evenly, a transparent alcohol-based no-wash gel with a certain viscosity is obtained.

[0069] Example 3

[0070] This embodiment presents an alcohol-based no-rinse gel with high transparency and good stability, prepared from the following raw materials in parts by weight, as shown in Table 3:

[0071] Table 3:

[0072]

[0073]

[0074] Specific operation method:

[0075] Weigh 0.55 parts thickener, 5.0 parts glycerin, and water, heat to 82℃ for sterilization, and stir to dissolve. Start homogenization at 1500 r / min for 2 min. Start cooling and when the temperature drops to 45℃, slowly and evenly add ethanol to the system while stirring. The ethanol should not be added too quickly, and the addition of ethanol should be completed within 5 min. After stirring evenly, add the pre-prepared pH adjuster to adjust the pH value and control the pH of the system to 6.3. After stirring evenly, a transparent alcohol-based no-wash gel with a certain viscosity is obtained.

[0076] Comparative Example 1

[0077] Comparative Example 1 and Example 2 have the same composition, but the processing method is different. Specifically, 0.40 parts of thickener, 4.0 parts of glycerin and water are weighed and heated to 85°C for sterilization and stirred to dissolve. Homogenization is started at 1200 r / min for 3 min. Cooling is started and when the temperature drops to 42°C, ethanol is added to the system in one go within 30 seconds while stirring. After stirring evenly, pH adjuster prepared in advance in water is added to adjust the pH value and control the pH of the system to 5.5. Finally, an alcohol-based no-wash gel with white flocculent substances is obtained.

[0078] Comparative Example 2

[0079] Comparative Example 2 has the same composition as Example 2, but the processing method is different. Specifically, 0.40 parts of thickener, 4.0 parts of glycerin and water are weighed and heated to 85°C for sterilization, and stirred to dissolve. Homogenization is started at 1200 r / min for 3 min. Cooling is started, and when the temperature drops to 42°C, ethanol is slowly and uniformly added to the system while stirring. The addition of ethanol is completed in 30 min. After stirring evenly, pH adjuster prepared in advance in water is added to adjust the pH value and control the pH of the system to 5.5. Finally, a product with good transparency but high fluidity and thinness is obtained.

[0080] Comparative Example 3

[0081] Comparative Example 3 has the same composition as Example 2, but the processing method is different. Specifically, 0.40 parts of thickener, 4.0 parts of glycerin and water are weighed and heated to 85°C for sterilization and stirred to dissolve. Homogenization is started at 1200 r / min for 3 min. Cooling is started and when the temperature drops to 42°C, the pH adjuster prepared in water is added while stirring to adjust the pH of the system to 5.5. Finally, ethanol is slowly and uniformly added to the system while stirring. The addition of ethanol is completed in 4 min. The final product is an alcohol-based no-wash gel with a slightly hazy appearance and low transparency.

[0082] Table 4 shows a comparison of the appearance and stability of the examples and comparative examples:

[0083] Table 4:

[0084]

[0085]

[0086] The alcohol-based no-rinse gel prepared in Example 2 was tested as follows:

[0087] 1. Non-sticky and quick-drying effect

[0088] The alcohol-based no-rinse gel prepared in Example 2 was compared with similar commercially available no-rinse products in the following efficacy experiments:

[0089] Forty participants were selected and divided into two groups of 20 each. The experimental group used the product prepared according to the formula in Example 2 of this invention, while the control group used a similar no-rinse product available on the market. 3 mL of the no-rinse gel was placed in the palm of the hand and evenly applied to the hands for thorough cleaning. The participants rubbed their hands together thoroughly for 1 minute, and their experiences and feedback were recorded.

[0090] Table 5: Comparison of Product Drying Speed ​​and Stickiness

[0091]

[0092] Feedback results show that 100% of testers found the gel of this invention to be quick-drying, completely drying within 10 seconds after thorough cleaning; and 95% of testers reported no stickiness after use. It outperforms commercially available products in terms of drying speed and non-stickiness.

[0093] II. Ethanol Content and Stability Test

[0094] The detection method is as follows:

[0095] Testing basis: Determination of ethanol content in 2.2.1.2.11 of the "Disinfection Technical Specifications" (2002 edition); Determination of stability of disinfection products in 2.2.3 of the "Disinfection Technical Specifications" (2002 edition).

[0096] Testing conditions: ambient temperature 22.3℃, relative humidity 62%.

[0097] The results are as follows:

[0098] The stability test results before and after storage are shown in Table 6:

[0099] Table 6: Stability Test Results

[0100]

[0101] The results above show that the gel prepared by this invention, after being stored at 54°C for 14 days, had an ethanol content of 72.5% (v / v), compared to 74.3% (v / v) before the stability test. The decrease in ethanol content was 2.4%, indicating that the gel prepared by this invention meets the requirement of ≤10% decrease in effective ingredient content in the "Disinfection Technical Specifications" (2002 edition). The shelf life of this sample can be at least 1 year.

[0102] III. Microbial Killing Test

[0103] A: Killing test against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa

[0104] Test strains: Staphylococcus aureus ATCC6538, Escherichia coli 8099, and Pseudomonas aeruginosa ATCC15422. All strains were of the 4th generation, and bacterial suspensions were prepared using 0.03 mol / L PBS.

[0105] Neutralizing agent: PBS solution containing 3% Tween 80.

[0106] Organic interfering agent: 3% bovine serum albumin

[0107] Testing basis: 2.1.1.5 Neutralizing agent identification test and 2.1.1.7 Quantitative bacterial killing test of the "Disinfection Technical Specifications" (2002 edition).

[0108] Preparation of bacterial suspension: Select bacterial content of 1*10 8 CFU / mL ~5*10 8 Neutralization identification test was performed on a bacterial suspension of CFU / mL.

[0109] Neutralizing agent identification test: The test bacteria was Escherichia coli. The test groups were: (1) disinfectant + bacterial tablets, (2) (disinfectant + bacterial tablets) + neutralizing agent, (3) neutralizing agent + bacterial tablets, (4) (disinfectant + neutralizing agent) + bacterial tablets, (5) diluent + neutralizing agent + culture medium. The sample was prepared by diluting the alcohol-based no-rinse gel of the present invention with the neutralizing agent by 1.5 times, acting for 1 minute, and the test was repeated 3 times.

[0110] Killing performance test: The quantitative bactericidal test was conducted by immersion in the carrier, with sample contact times of 30s, 1min, and 1.5min, and the test was repeated 3 times. The test environment temperature was 21℃~22℃.

[0111] The results are as follows:

[0112] (1) Neutralizing agent identification test

[0113] Three repeated experiments confirmed that the average number of colonies in group 1 was sterile growth, while the average number of colonies in group 2 was 1.1 x 10^6. 2CFU / tablet, the average number of colonies grown in groups 3, 4 and 5 were similar, with an error rate of 4.64% among the three groups, and no colonies grew in group 6.

[0114] The specific results are shown in Table 7:

[0115] Table 7: Results of Neutralizing Agent Identification Tests

[0116]

[0117] Note: The negative control showed no sterile growth.

[0118] (2) Killing effect on Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa

[0119] Three repeated experiments demonstrated that, after 30 seconds of contact, the sample exhibited a kill value of >3.00 against Staphylococcus aureus, >3.00 against Escherichia coli, and >3.00 against Pseudomonas aeruginosa. Specific results are shown in Table 8.

[0120] Table 8: Killing results of samples against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa

[0121]

[0122] Note: The negative control showed no sterile growth.

[0123] Conclusion: Using PBS containing 3% Tween 80 as a neutralizing agent, the alcohol-based hand sanitizer gel of this invention, after 1 minute of contact, showed a log reduction of >3.00 against Staphylococcus aureus, >3.00 against Escherichia coli, and >3.00 against Pseudomonas aeruginosa. The alcohol-based hand sanitizer gel prepared by this invention meets the requirements of the "Disinfection Technical Specifications" (2002 edition).

[0124] B: Killing test against Candida albicans

[0125] Test strain: Candida albicans ATCC 10231. The strain was in its 4th generation, and a bacterial suspension was prepared using 0.03 mol / L PBS.

[0126] Neutralizing agent: PBS solution containing 3% Tween 80.

[0127] Organic interfering agent: 3% bovine serum albumin

[0128] Testing basis: 2.1.1.5 Neutralizing agent identification test and 2.1.1.7 Quantitative bacterial killing test of the "Disinfection Technical Specifications" (2002 edition).

[0129] Preparation of bacterial suspension: Select bacterial content of 1*10 8 CFU / mL ~5*108 Neutralization identification test was performed on a bacterial suspension of CFU / mL.

[0130] Neutralizing agent identification test: The test bacteria was Escherichia coli. The test groups were: (1) disinfectant + bacterial tablets, (2) (disinfectant + bacterial tablets) + neutralizing agent, (3) neutralizing agent + bacterial tablets, (4) (disinfectant + neutralizing agent) + bacterial tablets, (5) diluent + neutralizing agent + culture medium. The sample was prepared by diluting the alcohol-based no-rinse gel of the present invention with the neutralizing agent by 1.5 times, acting for 1 minute, and the test was repeated 3 times.

[0131] Killing performance test: The quantitative bactericidal test was conducted by immersion in the carrier, with sample contact times of 30s, 1min, and 1.5min, and the test was repeated 3 times. The test environment temperature was 21℃~22℃.

[0132] The results are as follows:

[0133] (1) Neutralizing agent identification test

[0134] Three repeated experiments confirmed that the average number of colonies in group 1 was sterile growth, while the average number of colonies in group 2 was 4.8 x 10^6. 2 CFU / tablet, the average number of colonies grown in groups 3, 4 and 5 were similar, with an error rate of 4.04% among the three groups, and no colonies grew in group 6.

[0135] The specific results are shown in Table 9:

[0136] Table 9: Neutralizing Agent Identification Test

[0137]

[0138] Note: The negative control showed no sterile growth.

[0139] (3) Killing effect on Candida albicans

[0140] Three repeated tests proved that the sample, after 30 seconds of contact, had a kill value of >3.00 against Candida albicans.

[0141] The specific results are shown in Table 10:

[0142] Table 10: Results of sample killing Candida albicans

[0143]

[0144] Note: The negative control showed no sterile growth.

[0145] Conclusion: Using PBS containing 3% Tween 80 as a neutralizing agent, the alcohol-based hand sanitizer gel of this invention exhibited a logarithmic kill rate of >3.00 against Candida albicans after 1 minute of contact. The alcohol-based hand sanitizer gel prepared according to this invention meets the requirements of the "Disinfection Technical Specifications" (2002 edition).

[0146] IV. On-site Hand Disinfection Experiment

[0147] Neutralizing agent: PBS solution containing 3% Tween 80.

[0148] Control sampling solution: 0.1% Tween 80PBS.

[0149] Testing basis: "Disinfection Technical Specifications" (2002 edition) 2.1.2.6 On-site test of disinfectant for hand disinfection.

[0150] Before disinfection: Have the subject rub their hands together thoroughly. With the left fingers together, moisten a sterile cotton swab in a test tube containing 10 mL of diluent, squeeze dry on the tube wall, and then swab the swab twice from the fingertips to the base of the fingers, rotating the swab after each swab. After sampling, aseptically cut the sampling end of the cotton swab into a neutralizing agent test tube as a positive control sample.

[0151] The right hand was disinfected according to the instructions for use of the disinfectant, with an action time of 1 minute. After disinfection, a neutralizing agent was used instead of the diluent. The same method as the positive control group was used to sample the natural bacteria remaining on the upper surface of the subject's right hand once, which was used as the sample for the experimental group.

[0152] The number of participants was 30. The experimental environment temperature was 21℃~22℃, and the relative humidity was 58%~68%.

[0153] The specific results are shown in Table 11.

[0154] Table 11: Results of field trials for hand disinfection

[0155]

[0156]

[0157] Note: No bacterial growth was observed in the negative control group.

[0158] Conclusion: Results from 30 trials showed that the alcohol-based hand sanitizer gel prepared in this invention, after 1 minute of application, achieved a kill rate of >1.00 against naturally occurring bacteria on the surface of hygienic hands. This meets the requirements of GB 27950-2011 "Hygienic Requirements for Hand Sanitizers". The residual naturally occurring bacteria after hand sanitization was ≤100 CFU / cm³. 2 The alcohol-based hand sanitizer gel prepared by this invention conforms to the requirements of 15982—2012 "Hospital Disinfection and Hygiene Standards".

[0159] In the description of this specification, the references to terms such as "one embodiment," "some embodiments," "example," "specific example," or "some examples," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the present invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples. Moreover, without contradiction, those skilled in the art can combine and integrate the different embodiments or examples described in this specification, as well as the features of different embodiments or examples.

[0160] Although embodiments of the present invention have been shown and described above, it is understood that the above embodiments are exemplary and should not be construed as limiting the present invention. Those skilled in the art can make changes, modifications, substitutions and variations to the above embodiments within the scope of the present invention.

Claims

1. A method for preparing an alcohol-based no-rinse gel, characterized in that: (a) Heat the thickener, humectant and water to 80~85 ℃, stir to dissolve and keep warm for 10~15 min; (b) Start homogenization, homogenize at a speed of 1000~1500 r / min, homogenize for 2~5 min; (c) Turn on the cooling and cooling. When the temperature drops to 41~46 ℃, slowly and uniformly add ethanol while stirring. The total time for adding the ethanol is 3~10 min. (d) Continue stirring, add pH adjuster while stirring, adjust the pH of the system to between 5.5 and 6.5, add water to make up to 100 parts of total weight, stir evenly to obtain a transparent alcohol no-wash gel with a certain viscosity. The alcohol-based no-rinse gel contains the following ingredients in proportions: by weight, every 100 parts of weight consists of 3.0 to 8.0 parts of humectant, 0.3 to 0.6 parts of thickener, 65 to 75 parts of ethanol, an appropriate amount of pH adjuster, and the remainder water. The moisturizer includes glycerin or butylene glycol; The thickener includes carbomer; The pH adjuster includes triethanolamine or tromethamine.

2. The preparation method according to claim 1, characterized in that: The concentration of the ethanol is greater than 95%.

3. The preparation method according to claim 1, characterized in that: The pH adjuster is provided in a water-soluble form.

4. The preparation method according to claim 3, characterized in that: The weight ratio of the pH adjuster to water is 1:5 to 1:

10.

5. The preparation method according to claim 1, characterized in that: The proportions of the raw materials are as follows: per 100 parts by weight, there are 4.0 to 6.0 parts of humectant, 0.35 to 0.55 parts of thickener, 68 to 73 parts of ethanol, an appropriate amount of pH adjuster, and the remainder water.

Images