Biochemical analysis equipment and reaction tube cleaning equipment

Abstract

A biochemical analysis device and a reaction tube cleaning device capable of reducing the number of useless wiping times and increasing the service life of a reaction tube. The biochemical analysis device comprises: a reaction tube for accommodating a sample to be tested; a holding mechanism for holding a plurality of nozzles; and an external cleaning mechanism disposed in a reaction tank and located outside the reaction tube, and wiping the outer wall of the reaction tube in conjunction with the movement of one of the plurality of nozzles held by the holding mechanism.

Description

Technical Field

[0001] The invention relates to a biochemical analysis device and a reaction tube cleaning device. Background Art

[0002] Biochemical analyzers are widely used as biochemical analysis devices that use the principle of photoelectric colorimetry to measure certain specific chemical components in body fluids. With the use of biochemical analysis devices, stains may remain on the outer wall of the reaction tube, thereby affecting the detection effect. In order to remove stains on the outer wall of the reaction tube, a commonly used method is to install a reaction tube cleaner in the reaction tank. By installing the reaction tube cleaner on the outside of the passage formed when each reaction tube rotates, the reaction tube cleaner cleans the outer wall of the reaction tube as the reaction tube rotates. However, in actual use, due to the deviation of the installation position of the reaction tube cleaner, a large force may be borne on one side of the reaction tube, scratching the reaction tube. In addition, as long as the reaction tube rotates, each reaction tube needs to pass through the reaction tube cleaner, which affects the service life of the reaction tube over the years. In addition, the reaction tube cleaner may age after long-term use at high temperature, and the damage to the reaction tube after aging is relatively large. Summary of the invention

[0003] In order to solve the above problems, the present invention provides a biochemical analysis device and a reaction tube cleaning device which can reduce the number of useless wiping times and increase the service life of the reaction tube.

[0004] The biochemical analysis device of technical solution 1 comprises: a reaction tube for accommodating a sample to be tested; a holding mechanism for holding a plurality of nozzles; and an external cleaning mechanism, which is arranged in a reaction tank and located outside the reaction tube, and wipes the outer wall of the reaction tube in conjunction with the action of one of the plurality of nozzles held by the holding mechanism.

[0005] According to the biochemical analysis device of technical solution 1, the outer walls of all reaction tubes are not wiped indiscriminately. Instead, after the reaction tubes are used, the nozzle is only used to perform specific actions (such as moving up and down in the reaction tube or spraying water to the external cleaning device outside the reaction tube) for the reaction tube that needs to be wiped, so that the external cleaning mechanism can wipe the outer wall of the reaction tube that needs to be wiped in conjunction with the specific action of the nozzle.

[0006] In the biochemical analysis device of technical solution 2, the external cleaning mechanism wipes the outer wall of the reaction tube by moving up and down along the height direction of the outer wall of the reaction tube.

[0007] In the biochemical analysis device of technical solution 3, the external cleaning mechanism wipes the outer wall of the reaction tube by moving in a circular motion along the outer wall of the reaction tube.

[0008] In the biochemical analysis device of technical solution 4, the external cleaning mechanism is linked to the movement of the first nozzle in the reaction tube to wipe the outer wall of the reaction tube.

[0009] According to the biochemical analysis device of technical solution 4, as one of the plurality of nozzles linked to the external cleaning mechanism enters the reaction tube and moves in the reaction tube, the external cleaning mechanism wipes the outer wall of the reaction tube.

[0010] In the biochemical analysis device of technical solution 5, one of the multiple nozzles is a water spray nozzle that is located obliquely above the reaction tube, cannot enter the interior of the reaction tube, and can spray water toward the external cleaning mechanism. The external cleaning mechanism wipes the outer wall of the reaction tube in conjunction with the water spray of the water spray nozzle.

[0011] According to the biochemical analysis device of technical solution 5, as the water spray nozzle located obliquely above the reaction tube to be wiped sprays water toward the external cleaning mechanism, the external cleaning mechanism wipes the outer wall of the reaction tube.

[0012] The biochemical analysis device of technical solution 6 also has a built-in cleaning mechanism, which includes a magnetic nozzle, which is held by the holding mechanism and can move in and out of the reaction tube in the up and down directions under the drive of the driving mechanism. The magnetic nozzle is one of the multiple nozzles, and the external cleaning mechanism has a magnetic wiper. The built-in cleaning mechanism and the external cleaning mechanism attract each other under the action of magnetic force.

[0013] According to the biochemical analysis device of technical solution 6, for the reaction tube that needs to be wiped, the magnetic nozzle enters the reaction tube, and the external cleaning mechanism approaches the magnetic nozzle under the action of magnetic force, and after contacting the outer wall of the reaction tube, wipes in the up and down direction to clean the outer wall of the reaction tube. For the reaction tube that does not need to be wiped, the magnetic nozzle does not enter the reaction tube, so that the outer wall of the reaction tube will not be wiped, which can reduce the number of useless wiping times and increase the service life of the reaction tube.

[0014] In the biochemical analysis device of technical solution 7, the magnetic nozzle has one of a magnet and a magnetic body, and is formed as a rod-shaped body extending in the up and down directions. The upper end of the magnetic nozzle is connected to the holding mechanism, and in the magnetic nozzle, one of the magnet and the magnetic body is located at the lower part of the magnetic nozzle.

[0015] In the biochemical analysis device of technical solution 8, the external cleaning mechanism further includes a moving mechanism, the magnetic wipe is composed of an external wipe and the other of a magnet and a magnetic body, the moving mechanism is fixed to the reaction tank, and holds the magnetic wipe, the external wipe of the magnetic wipe is arranged opposite to the outer wall of the reaction tube with a gap therebetween, and the other of the magnet and the magnetic body is located on the side of the external wipe opposite to the reaction tube. As the rod-shaped body moves in the reaction tube, the magnetic wipe is brought closer to the reaction tube under the action of magnetic force, and the magnetic wipe is made to slide up and down along the outer wall of the reaction tube by the moving mechanism to wipe.

[0016] According to the biochemical analysis device of technical solution 7 and technical solution 8, the magnetic nozzle has one of a magnet and a magnetic body, and the external cleaning mechanism has the other of the magnet and the magnetic body. When the magnetic nozzle enters the interior of the reaction tube, the magnetic force generated between the magnet and the magnetic body attracts the external cleaning mechanism to the outer wall of the reaction tube and contacts the outer wall. In addition, as the magnetic nozzle equipped with the magnet or the magnetic body moves up and down in the reaction tube, the external cleaning mechanism can wipe the outer wall of the reaction tube in the up and down direction.

[0017] In the biochemical analysis device of technical solution 9, the built-in cleaning mechanism further includes a limit block, and the limit block limits the trajectory of the magnetic nozzle moving in the up and down directions so that the magnetic nozzle does not tilt.

[0018] According to the biochemical analysis device of technical solution 9, by arranging a limit block on the magnetic nozzle, when the magnetic nozzle enters and exits the reaction tube, the limit block can limit the movement trajectory of the magnetic nozzle in the reaction tube, thereby avoiding the magnetic nozzle from tilting due to magnetic attraction.

[0019] In the biochemical analysis device of technical solution 10, the limit block is arranged on a part of the magnetic nozzle in a manner of covering the magnetic nozzle, is made of a soft material, and the size of the limit block is less than or equal to the inner diameter of the reaction tube.

[0020] According to the biochemical analysis device of technical solution 10, the stopper can be provided in a manner of directly covering the nozzle portion of the magnetic nozzle, or in a manner of covering the nozzle portion of the magnetic nozzle via a magnet (or magnetic body). The size of the stopper is less than or equal to the inner diameter of the reaction tube, and is made of a soft material, so that even if the stopper contacts the inner wall of the reaction tube, the inner wall of the reaction tube will not be damaged.

[0021] In the biochemical analysis device of technical solution 11, the built-in cleaning mechanism further includes another nozzle different from the magnetic nozzle that can enter and exit the reaction tube and clean and dry the inner wall of the reaction tube.

[0022] According to the biochemical analysis device of technical solution 11, the built-in cleaning mechanism has other nozzles in addition to the magnetic nozzle with a magnet (or magnetic body) installed at the bottom. The magnetic nozzle with a magnet (or magnetic body) installed at the bottom is a magnetic nozzle that can attract the external cleaning mechanism to wipe the outer wall of the reaction tube, and the other nozzle is a nozzle for cleaning and drying the inner wall of the reaction tube.

[0023] In the biochemical analysis device of technical solution 12, the magnetic nozzle of the built-in cleaning mechanism also has a dry object, which is connected to the bottom of the magnet (or magnetic body) and moves up and down together with the magnet (or magnetic body) under the drive of the driving mechanism to dry the inner wall of the reaction tube.

[0024] According to the biochemical analysis device of technical solution 12, a dry object is also provided below the magnetic nozzle composed of a magnet (or magnetic body) and a nozzle part. By moving the magnet (or magnetic body) and the dry object up and down together, the inner wall of the reaction tube can be dried while wiping the outer wall of the reaction tube.

[0025] In the biochemical analysis device of technical solution 13, the built-in cleaning mechanism further includes another nozzle different from the magnetic nozzle that can enter and exit the reaction tube and clean the inner wall of the reaction tube.

[0026] According to the biochemical analysis device of technical solution 13, the built-in cleaning mechanism has, in addition to the magnetic nozzle having a dried object arranged below and capable of performing a drying function, another nozzle having a cleaning function different from the magnetic nozzle. The magnetic nozzle and the other nozzle are arranged side by side, and after the other nozzle having a cleaning function cleans the reaction tube, the magnetic nozzle having the dried object arranged enters the reaction tube, and while drying the inner wall of the reaction tube, the external cleaning mechanism is attracted to wipe the outer wall of the reaction tube.

[0027] In the biochemical analysis device of technical solution 14, the external cleaning mechanism is provided in plurality, and is arranged at least on the front wall and the rear wall of the reaction tank to wipe the front surface and the rear surface of the reaction tube.

[0028] The front surface and the rear surface of the reaction tube are two opposite surfaces of the reaction tube through which light passes during biochemical analysis. According to the biochemical analysis device of technical solution 14, the external cleaning mechanism is at least arranged on the front wall and the rear wall of the reaction tank at a position capable of cleaning the front surface and the rear surface of the reaction tube, thereby ensuring that at least the two surfaces of the reaction tube through which light passes are cleaned, thereby improving the photometric accuracy.

[0029] In the biochemical analysis device of technical solution 15, when the internal cleaning mechanism has a magnetic body and the external cleaning mechanism has a magnet, the polarity of the magnet arranged on the front wall of the reaction tank is opposite to that of the magnet arranged on the rear wall of the reaction tank.

[0030] In the biochemical analysis device of technical solution 16, the moving mechanism includes: a first slider, a second slider, a spring and a slide, the slide is fixed to the reaction tank, one end of the first slider is arranged in the slide so that it can reciprocate along the extension direction of the slide, the other end of the first slider partially overlaps with one end of the second slider in the extension direction of the slide, and can slide relative to each other in a direction perpendicular to the extension direction, the one end of the second slider is connected to the slide via the spring, and the other end of the second slider is connected to the magnet (or the magnetic body).

[0031] In the biochemical analysis device of technical solution 17, the moving mechanism includes: a slide and a spring, one end of the spring is fixed to the reaction tank, and the other end is fixed to the back side of the slide, the elastic force direction of the spring is perpendicular to the extension direction of the slide, the slide extends in a direction parallel to the reaction tube, and the magnetic wipe is arranged in the slide and can move back and forth along the extension direction of the slide.

[0032] In the biochemical analysis device of technical solution 18, the moving mechanism includes: a slide, a spring and a block, one end of the block is fixed to the reaction tank, and the other end is connected to the slide via the spring and blocks the movement of the slide in the direction of the elastic force, and the slide has: a first part parallel to the reaction tube for setting the magnetic wipe, a second part connected to the spring and limited by the block, and a third part connecting the first part with the second part.

[0033] According to any one of the biochemical analysis devices in Technical Solutions 16 to 18, the external cleaning mechanism can be attracted to the outer wall of the reaction tube and wiped as the magnetic nozzle enters the reaction tube, and the external cleaning mechanism can return to its initial position separated from the outer wall of the reaction tube as the magnetic nozzle leaves the reaction tube.

[0034] In the biochemical analysis device of technical solution 19, one of the multiple nozzles is a first nozzle located directly above the reaction tube and capable of entering and exiting the reaction tube in the up and down directions. The external cleaning mechanism includes: a connecting plate, a guide groove, a chain and a wiper. The connecting plate is held by the holding mechanism and extends downward. It is located on both sides of the first nozzle and is arranged on the same plane as the first nozzle. The lower end is connected to the chain. The guide groove guides the movement of the chain. The wiper is connected to the lower end of the chain and is clamped between the guide groove and the reaction tube to wipe the outer wall of the reaction tube.

[0035] In the biochemical analysis device of technical solution 20, the guide groove is configured so that the distance between the lower part and the reaction tube is smaller than that between the upper part and the lower part, and the distance between the lower part and the reaction tube is less than the thickness of the wipe.

[0036] According to the biochemical analysis device of technical solution 19 or 20, the holding device holds the connecting plate in addition to the first nozzle. When the first nozzle enters and exits the reaction tube, the connecting plate moves in the up-down direction together with the first nozzle, and the moving track of the chain connected to the connecting plate is guided by the guide groove, thereby driving the wiper installed on the chain to wipe the outer wall of the reaction tube. In this way, the outer wall of the reaction tube can be wiped in conjunction with the movement of one nozzle (the first nozzle) among the multiple nozzles held by the holding device.

[0037] In the biochemical analysis device of technical solution 21, the external cleaning mechanism includes a first external cleaning mechanism, which has: an impeller and a first magnetic wiper, the impeller is fixed in the reaction tank and is located directly below the water spray nozzle, and is rotated by water sprayed from the water spray nozzle, and the first magnetic wiper is sandwiched between the reaction tube and the impeller in a manner such that the wiping surface contacts the reaction tube and the magnetic surface contacts the impeller.

[0038] In the biochemical analysis device of technical solution 22, the external cleaning mechanism also includes the second external cleaning mechanism, and the second external cleaning mechanism includes a second magnetic wipe. The second magnetic wipe is arranged at a position opposite to the first magnetic wipe across the reaction tube in such a way that the wiping surface of the second magnetic wipe contacts the reaction tube and the magnetic surface is fixed in the reaction tank. The first magnetic wipe and the second magnetic wipe have opposite magnetic properties.

[0039] According to the biochemical analysis device of technical solution 21 or 22, the water spraying action from the water spraying nozzle held by the holding device is used to drive the impeller of the external cleaning mechanism to rotate the first magnetic wiper under the impact of water, thereby wiping the outer wall of the reaction tube. Similarly, the outer wall of the reaction tube can be wiped in conjunction with the action of the nozzle (water spraying nozzle) held by the holding device.

[0040] The reaction tube cleaning device of technical solution 23 comprises: a holding mechanism for holding a plurality of nozzles; and an external cleaning mechanism, which is arranged in a reaction tank and located outside the reaction tube, and wipes the outer wall of the reaction tube in conjunction with the action of one of the plurality of nozzles held by the holding mechanism.

[0041] Effects of the Invention

[0042] In the present invention, only the outer wall of the reaction tube that needs to be wiped can be wiped, and it is not necessary to wipe the outer wall of all the reaction tubes when the reaction tubes rotate, thereby reducing the number of useless wiping times and increasing the service life of the reaction tubes. BRIEF DESCRIPTION OF THE DRAWINGS

[0043] Figure 1A is a schematic top view of a biochemical analysis device having a reaction tube cleaner of the prior art, Figure 1B yes Figure 1A Schematic diagram of a holding mechanism holding a nozzle.

[0044] Figure 2A is a schematic plan view showing a biochemical analysis device according to a first embodiment, Figure 2B Yes means Figure 2A A schematic diagram of the structure of an external cleaning mechanism in a biochemical analysis device. Figure 2C Yes means Figure 2A Schematic diagram of the structure of the built-in washing mechanism in the biochemical analysis device.

[0045] Figure 3A to Figure 3D The diagram shows a process in which a magnetic nozzle having a magnet in the biochemical analysis apparatus according to the first embodiment enters a reaction tube and moves out of the reaction tube.

[0046] Figure 4A The schematic diagram shows the situation where the magnet is attracted and deflected by the magnetic wiper of the external cleaning mechanism. Figure 4B A schematic diagram showing the structure of a built-in cleaning mechanism having a stopper according to a second embodiment.

[0047] Figure 5 It is a schematic diagram showing the structure of a built-in cleaning mechanism of a biochemical analyzer according to a third embodiment.

[0048] Figures 6A to 6CThe process from the internal cleaning mechanism of the biochemical analyzer according to the third embodiment entering the reaction tube to drying the bottom of the reaction tube is shown.

[0049] Figure 7 It is a schematic diagram showing the structure of an external cleaning mechanism of a biochemical analyzer according to a fourth embodiment.

[0050] Figure 8 It is a schematic diagram showing the structure of an external cleaning mechanism of a biochemical analyzer according to a fifth embodiment.

[0051] Figures 9A to 9C The moving process of the external cleaning mechanism of the biochemical analyzer according to the fifth embodiment is shown, from the time when the magnet enters the reaction tube to the time when it descends to the bottom.

[0052] Fig.10 It is a schematic diagram showing the structure of an external cleaning mechanism of a biochemical analyzer according to a sixth embodiment.

[0053] Figures 11A to 11C The moving process of the external cleaning mechanism according to the sixth embodiment from when the magnet enters the reaction tube to when it descends to the bottom is shown.

[0054] Fig.12 It is a schematic diagram showing the structure of a biochemical analysis device according to the seventh embodiment.

[0055] Fig.13A A schematic plan view of a nozzle held by a holding mechanism according to an eighth embodiment is shown. Fig. 13B A schematic diagram showing the structure of a biochemical analysis device according to an eighth embodiment.

[0056] Fig.14A A schematic plan view of a nozzle held by a holding mechanism according to a ninth embodiment is shown. Fig. 14B A schematic diagram showing the structure of a biochemical analysis device according to a ninth embodiment.

[0057] Figures 15A to 15C The operation mode of the biochemical analysis device according to the ninth embodiment is shown. DETAILED DESCRIPTION

[0058] Hereinafter, the embodiments will be described with reference to the accompanying drawings. The embodiments described below do not limit the present invention. In addition, in the following description, the same reference numerals are given to components having substantially the same functions and configurations, and repeated descriptions are performed only when necessary.

[0059] Figure 1A1 is a top view schematic diagram of a biochemical analysis device with a reaction tube cleaner of the prior art. In the reaction tank of the biochemical analysis device, multiple reaction tubes are arranged along the circumference, and when the reaction tubes rotate, a reaction tube rotation path shown in FIG1 is formed. A holding mechanism for holding multiple nozzles is provided above the reaction tank of the biochemical analysis device. By driving the nozzles held by the holding mechanism into the reaction tube under the drive of the driving mechanism, various treatments can be performed on the inner wall of the reaction tube. For example, Figure 1B As shown, the conventional holding mechanism has 8 nozzles, the nozzles numbered ① to ⑦ are used to clean the reaction tube, and the nozzle numbered ⑧ is used to dry the reaction tube. Figure 1A Only the reaction tubes corresponding to the plurality of nozzles numbered ① to ⑧ held by the holding mechanism are shown in the figure, and the other reaction tubes in the circumferential direction are omitted from the figure.

[0060] In addition, if Figure 1A As shown, a reaction tube cleaner is also installed in the reaction tank. This is because, after the reaction tube is used, stains may be attached to the outer wall, so the outer wall also needs to be cleaned. In order to clean the outer wall of the reaction tube, the reaction tube cleaner is located on the outside of the passage formed when each reaction tube rotates, and the reaction tube cleaner cleans the outer wall of the reaction tube as the reaction tube rotates. However, as mentioned above, when using the reaction tube cleaner, the reaction tube may be scratched due to deviation in the installation position, or all reaction tubes are cleaned without distinction between reaction tubes that need to be wiped and reaction tubes that do not need to be wiped (for example, unused), which affects the service life of the reaction tube. Therefore, it is expected that there will be a biochemical analysis device that can reduce the number of useless wiping times and increase the service life of the reaction tube.

[0061] The present invention provides a biochemical analysis device, comprising: a reaction tube for accommodating a sample to be tested; a holding mechanism for holding a plurality of nozzles; and an external cleaning mechanism, which is arranged in a reaction tank and located outside the reaction tube, and is linked to the action of one of the plurality of nozzles held by the holding mechanism to wipe the outer wall of the reaction tube.

[0062] The biochemical analysis device of the present invention is described in detail below through some embodiments, but the embodiments are merely illustrative and can be modified in various ways without departing from the main purpose of the invention. In addition, in the following embodiments, only the part of the biochemical analysis device that performs the reaction tube cleaning function is described, and the description of other parts is omitted.

[0063] (First Embodiment)

[0064] Figure 2A It is a schematic plan view showing the biochemical analysis device according to the first embodiment.

[0065] like Figure 2AAs shown, the biochemical analysis device of the first embodiment comprises a built-in cleaning mechanism 2, which is held by a holding mechanism 3 and moves in and out of the reaction tube in the up and down directions under the drive of a driving mechanism; and an external cleaning mechanism 1, which is arranged in the reaction tank and located outside the reaction tube, and cleans the outer wall of the reaction tube in conjunction with the movement of the built-in cleaning mechanism 2 in the reaction tube, and the built-in cleaning mechanism 2 and the external cleaning mechanism 1 attract each other under the action of magnetic force. Figure 2A For the convenience of illustration, the built-in cleaning mechanism 2 and the holding mechanism 3 are shown in parallel with the reaction tube, but in fact, the built-in cleaning mechanism 2 and the holding mechanism 3 are located above the reaction tube.

[0066] Figure 2B Yes means Figure 2A Schematic diagram of the structure of the external cleaning mechanism 1 in FIG. The reference numerals A and B respectively represent a reaction tube and a reaction tank, and the reference numerals A and B are omitted for simplicity of illustration.

[0067] The external cleaning mechanism 1 comprises a magnetic wiper 10 and a moving mechanism 13. The magnetic wiper 10 is composed of an external wiper 11 and a magnetic body 12. The external wiper 11 is made of a material that does little damage to the reaction tube and has a long service life, such as organic silica gel, a brush, a fiber cloth, etc.

[0068] The external wipe 11 has a first surface and a second surface located on the opposite side of the first surface, and the external wipe 11 is arranged in a manner that the first surface faces the outer wall of the reaction tube with a gap therebetween. The magnetic body 12 is arranged on the second surface side of the external wipe 11 and is arranged in contact with the second surface. Thus, the magnetic body 12 is arranged on the surface of the external wipe 11 on the side opposite to the reaction tube.

[0069] The moving mechanism 13 is configured to move the magnetic wiper 10 toward the reaction tube and move up and down under the action of magnetic force as the rod-shaped body moves in the reaction tube. Here, only a block diagram of the moving mechanism 13 is schematically shown, and the structure of the moving mechanism 13 is not limited as long as the magnetic wiper 10 can move in the up and down directions and the front and back directions.

[0070] in addition, Figure 2B The figure shows a case where external cleaning mechanisms 1 are respectively arranged on the opposite front and rear surfaces of the reaction tube. This is because the front and rear surfaces of the reaction tube correspond to the two opposite surfaces of the reaction tube through which light passes during biochemical analysis. By arranging the external cleaning mechanisms at least on the front and rear walls of the reaction tank and at positions capable of cleaning the front and rear surfaces of the reaction tube, it is possible to ensure that at least the two surfaces of the reaction tube through which light passes are cleaned. Figure 2BIn the figure, only the external cleaning mechanism 1 disposed on the front wall of the reaction tank is marked with a reference numeral, and the external cleaning mechanism 1 disposed on the rear wall of the reaction tank has the same structure, so the reference numeral is omitted. In the following description and drawings, there are also cases where only the external cleaning mechanism 1 on the front wall of the reaction tank is marked, while the marking of the external cleaning mechanism 1 on the rear wall is omitted. In addition, the external cleaning mechanism 1 can also be set on other surfaces of the reaction tube.

[0071] Figure 2C Yes means Figure 2A Schematic diagram of the structure of the built-in cleaning mechanism in the first embodiment. Figure 1B A new magnetic nozzle with a magnet is added on the basis. That is to say, in addition to the nozzles ① to ⑧ for cleaning and drying the inner wall of the reaction tube in the prior art, the built-in cleaning mechanism 2 also has a magnetic nozzle with a magnet and a nozzle part represented by the number ⑨. The nozzle part is a hollow rod-shaped body that can flow gas or liquid like the nozzle. Here, in order to distinguish it from the nozzles ① to ⑧, the nozzle constituting the magnetic nozzle is called the nozzle part. The magnetic nozzle is one of the multiple nozzles held by the holding mechanism that can be linked with the external cleaning mechanism. The above-mentioned nozzles ① to ⑨ are arranged directly above the reaction tube and can enter and exit the reaction tube in the up and down directions. Among the nozzles ① to ⑨, the nozzle ⑨ with a magnet held by the holding mechanism 3 is set as the magnetic nozzle, and the nozzles ① to ⑧ without a magnet held by the holding mechanism 3 are set as other nozzles.

[0072] The magnetic nozzle and other nozzles are held in parallel by the holding mechanism 3 . The magnetic nozzle has a magnet at its lower portion compared to the other nozzles. Figure 2C The magnetic nozzle composed of the nozzle part and the magnet is formed into a rod-shaped body. In the magnetic nozzle, the magnet is arranged on the periphery of the nozzle part in a manner of surrounding the outer peripheral surface of the nozzle part without blocking the nozzle part. Therefore, the magnet can have no influence on the function of the nozzle part.

[0073] The magnetic nozzle included in the built-in cleaning mechanism 2 extends in the vertical direction, and its upper end is connected to the holding mechanism 3 . In the magnetic nozzle, the magnet is located at the lower part of the magnetic nozzle.

[0074] When the magnetic nozzle with magnet moves toward the reaction tube and enters the interior of the reaction tube, the magnetic wiper 10 with magnetic body approaches the reaction tube under the action of magnetic force and slides along the outer wall of the reaction tube to wipe.

[0075] Next, the operation process of wiping the outer wall of the reaction tube by magnetic force will be described with reference to FIG. 3 .

[0076] Figures 3A to 3DThe figure shows the process of the magnetic nozzle with magnet from entering the reaction tube to moving out of the reaction tube.

[0077] like Figure 3A As shown, when the outer wall of a reaction tube needs to be wiped, the magnetic nozzle with a magnet is moved to the upper part of the reaction tube and enters the reaction tube from the upper part. When the distance between the magnet and the magnetic body is greater than a predetermined distance, a fixed interval is maintained between the magnetic body and the outer wall of the reaction tube.

[0078] like Figure 3B As shown, when the magnetic nozzle with a magnet enters the interior of the reaction tube and the distance between the magnet and the magnetic body is less than a specified distance, under the action of the magnetic force, the magnetic body drives the external wiper toward the magnet until the external wiper adheres to the outer wall of the reaction tube.

[0079] Then, if Figure 3C As shown, as the magnet moves inside the reaction tube, the magnetic wiper outside the reaction tube moves in conjunction with the movement of the magnet and wipes along the outer wall of the reaction tube.

[0080] Then, if Figure 3D As shown, when the magnetic nozzle with a magnet moves upwardly toward the reaction tube and the distance between the magnet and the magnetic body is greater than the minimum distance between the two that can generate magnetic force, the magnetic wiper returns to its initial position, i.e., a position at which it maintains a fixed distance from the outer wall of the reaction tube, under the action of the moving mechanism.

[0081] Thereby, the wiping process of the outer wall of the reaction tube is completed.

[0082] The cleaning process of the outer wall of the reaction tube is generally performed after the cleaning process of the inner wall of the reaction tube, for example, after the inside of the reaction tube is cleaned and dried by other nozzles, the outer wall of the reaction tube is wiped by a magnetic nozzle having a magnet. However, this order is not limited to this, and the outer wall can be wiped alone without cleaning and drying the inside.

[0083] The biochemical analysis device of the first embodiment can only wipe the outer wall of the reaction tube that needs to be wiped, and not wipe the reaction tube that does not need to be wiped, thereby reducing the number of useless wiping times and increasing the service life of the reaction tube.

[0084] (Second Embodiment)

[0085] The difference between the second embodiment and the first embodiment is that the lower part of the magnet in the second embodiment further has a stopper to prevent the magnet from shifting.

[0086] Figure 4A The schematic diagram shows the situation where the magnet is attracted by the magnetic body of the external cleaning mechanism and deviates. Figure 4BA schematic diagram showing the structure of a built-in cleaning mechanism having a stopper according to a second embodiment.

[0087] As described in the first embodiment, the internal cleaning mechanism includes a magnetic nozzle composed of a magnet and a nozzle portion, and the external cleaning mechanism includes a magnetic wiper and a moving mechanism, and the magnetic wiper is composed of an external wiper and a magnetic body. It is known that the magnet in the internal cleaning mechanism will be attracted by the magnetic body in the external cleaning mechanism during the descent process. If the holding mechanism for holding the magnetic nozzle with the magnet is offset above the reaction tube, or there is a difference in the distance between the external cleaning mechanism on the front and rear surfaces of the reaction tube and the reaction tube, then Figure 4A As shown, the magnet in the magnetic nozzle is attracted by the magnetic body of the external cleaning mechanism and deviates, causing the magnetic nozzle to tilt.

[0088] In order to prevent the magnetic nozzle from tilting, you can consider Figure 4B As shown in the figure, a stopper is installed at the front end of the magnet. The stopper can limit the trajectory of the magnetic nozzle moving up and down so that it does not tilt.

[0089] In addition, in order to reliably limit the moving track of the magnetic nozzle, it is preferred that the size of the stopper is slightly smaller than or equal to the inner diameter of the reaction tube. The stopper is made of a soft material that will not damage the inner wall of the reaction tube, such as organic silica gel, a brush, a fiber cloth, etc.

[0090] In addition, although Figure 4B The figure shows that the limit block is set at the lower part of the magnetic nozzle in a way of covering the lower end of the magnet, but as long as the moving trajectory of the magnetic nozzle can be limited, the limit block can also be set at other parts of the magnetic nozzle, for example, the limit block can also be set at the nozzle part.

[0091] In addition, similar to the first embodiment, the biochemical analysis device of the second embodiment can also wipe only the outer wall of the reaction tube that needs to be wiped, and not wipe the reaction tube that does not need to be wiped, thereby reducing the number of useless wiping times and increasing the service life of the reaction tube.

[0092] (Third Embodiment)

[0093] The difference between the third embodiment and the first embodiment is that the built-in cleaning mechanism of the third embodiment is not Figure 1B Instead of adding a new magnetic nozzle to the built-in cleaning mechanism, a magnet is added to the nozzle that performs the drying function to serve as a magnetic nozzle.

[0094] Figure 5 It is a schematic diagram showing the structure of the built-in cleaning mechanism of the third embodiment.

[0095] exist Figure 5 In the above, the nozzles numbered ① to ⑦ do not need to be modified and can be used directly. Figure 1B The structure is different from that of the first embodiment, but a magnet is added to the nozzle portion numbered ⑧. The nozzle ⑧, which plays a drying role, originally has a nozzle portion and a dried object. In this embodiment, a magnet is added between the nozzle portion and the dried object to make the nozzle ⑧ a magnetic nozzle. As in the first embodiment, the magnetic nozzle is formed into a rod-shaped body extending in the vertical direction. Thus, in the built-in cleaning mechanism 2 of the third embodiment, in addition to having the prior art Figure 1B In addition to nozzles ① to ⑦ for cleaning the inner wall of the reaction tube, there is also a magnetic nozzle ⑧ that simultaneously performs a drying function and a suction function for the external cleaning device.

[0096] As in the first embodiment, the nozzle with a magnet held by the holding mechanism 3 is referred to as a magnetic nozzle, and the nozzle without a magnet held by the holding mechanism 3 is referred to as another nozzle. Figure 5 As shown in the right figure of , the magnetic nozzle includes a nozzle part, a magnet and a dried object from top to bottom. In this embodiment, the magnet is also arranged in a manner of surrounding the outer peripheral surface of the nozzle part. Therefore, the magnet has no effect on the function of the nozzle part. In this embodiment, air is supplied to the dried object or moisture is extracted through the nozzle part, thereby keeping the dried object dry.

[0097] In addition, in order to reliably dry the bottom of the reaction tube, it is necessary to place the dried object at the lower end of the magnetic nozzle. In other words, a stack of a magnet and dried object is placed at the lower end of the magnetic nozzle and the dried object is located below the magnet. By having the dried object on one magnetic nozzle, it is possible to dry the inside of the reaction tube and wipe the outer wall at the same time.

[0098] Figures 6A to 6C The process from the internal cleaning mechanism according to the third embodiment entering the reaction tube to drying the bottom of the reaction tube is shown.

[0099] like Fig. 6A As shown, when drying the interior of a certain reaction tube, a magnetic nozzle having a nozzle portion, a magnet and a dried object is moved to the upper side of the reaction tube and enters the reaction tube from the upper side. When the distance between the magnet and the magnetic body is greater than a predetermined distance, a fixed interval is maintained between the magnetic body and the outer wall of the reaction tube.

[0100] like Figure 6B As shown, when the magnet on the magnetic nozzle enters the interior of the reaction tube and the distance between the magnet and the magnetic body in the magnetic wiper is less than the specified distance, under the action of the magnetic force, the magnetic body drives the external wiper to approach the magnet until the external wiper adheres to the outer wall of the reaction tube.

[0101] Then, if Figure 6C As shown, as the magnet moves inside the reaction tube, the magnetic wiper outside the reaction tube moves in conjunction with the movement of the magnet, wiping along the outer wall of the reaction tube, and as the dry object at the lower end of the magnetic nozzle moves inside the reaction tube, the inner wall of the reaction tube is dried, and when the dry object reaches the bottom of the reaction tube, the bottom of the reaction tube is also dried.

[0102] Thus, according to the third embodiment, the outer wall of the reaction tube can be wiped and the inside of the reaction tube can be dried at the same time.

[0103] The wiping process of the outer wall of the reaction tube and the drying process of the interior are generally performed after the cleaning process of the inner wall of the reaction tube. For example, after the interior of the reaction tube is cleaned by other nozzles, the outer wall of the reaction tube is cleaned and the interior is dried at the same time by using a magnetic nozzle having a nozzle part, a magnet and a dried object. However, the order is not limited to this, and the wiping of the outer wall and the drying of the interior may be performed alone without cleaning the interior.

[0104] The biochemical analysis device of the third embodiment can also wipe only the outer wall of the reaction tube that needs to be wiped, and not wipe the reaction tube that does not need to be wiped, thereby reducing the number of useless wiping times and increasing the service life of the reaction tube.

[0105] (Fourth Embodiment)

[0106] In the first to third embodiments, several modifications are described mainly with respect to the internal cleaning device in the biochemical analysis device. From the fourth embodiment onwards, several modifications are described mainly with respect to the external cleaning device in the biochemical analysis device.

[0107] Figure 7 It is a schematic diagram showing the structure of an external cleaning mechanism according to a fourth embodiment.

[0108] The external cleaning mechanism 1 of the fourth embodiment is similar to the external cleaning mechanism 1 of the first embodiment, and includes: a magnetic wiper 10 and a moving mechanism 13. Among them, regarding the magnetic wiper 10, the fourth, fifth, and sixth embodiments adopt the same structure as the first embodiment, so the relevant description is omitted below. Here, only the structure of the moving mechanism 13, the connection relationship between the moving mechanism 13 and the magnetic wiper 10, and the connection relationship between the moving mechanism 13 and the reaction tank, which are omitted from the detailed description in the first embodiment, are described.

[0109] like Figure 7As shown, the moving mechanism 13 has a first slider 14, a second slider 15, a spring 16 and a slide 17. The slide 17 has a surface side for mounting the first slider 14 and a back side which is the side opposite to the surface side. The back side is fixed inside the reaction tank via a fixing device. Figure 7 The fixing method shown is just an example and is not limited to this.

[0110] The slide 17 extends in a direction parallel to the extension direction of the outer wall of the reaction tube, and the extension direction of the slide 17 is hereinafter referred to as the Y direction. One end of the first slider 14 is arranged in a track formed on the surface side of the slide 17 so as to be reciprocable along the extension direction of the slide 17, i.e., the Y direction. The first slider 14 and the slide 17 are arranged perpendicular to each other, and the extension direction of the first slider 14 is hereinafter referred to as the X direction. The other end of the first slider 14 partially overlaps with one end of the second slider 15 in the extension direction of the slide 17, i.e., the Y direction, and can slide relatively along the X direction. One end of the second slider 15 is connected to the track on the surface side of the slide 17 via a spring 16, and the other end of the second slider 15 is fixed perpendicularly to the magnetic body 12 on the side of the magnetic body 12 opposite to the external wipe 11.

[0111] By adopting the above structure, the magnetic body 12 of the external cleaning mechanism 1 can be attracted to the outer wall of the reaction tube by magnetic force when the magnet 21 of the built-in cleaning mechanism 2 enters the reaction tube, and moves up and down along the outer wall of the reaction tube as the magnet 21 moves in the reaction tube, and drives the external wiper to wipe the outer wall of the reaction tube. During the whole wiping process, the spring 16 is stretched. When the magnet 21 of the built-in cleaning mechanism 2 is removed from the reaction tube and the distance between the magnet and the magnetic body is greater than the specified distance, the magnetic wiper 10 returns to the initial position separated from the outer wall of the reaction tube under the action of the restoring force of the spring.

[0112] Thus, the biochemical analysis device of the fourth embodiment can only wipe the outer wall of the reaction tube that needs to be wiped, and not wipe the reaction tube that does not need to be wiped, thereby reducing the number of useless wiping times and increasing the service life of the reaction tube.

[0113] (Fifth Embodiment)

[0114] The fifth embodiment differs from the fourth embodiment in that, in order to ensure the strength of the external cleaning mechanism, the slide is not disposed near the reaction tank but near the magnetic wiper, and a spring is fixed to the reaction tank instead of the slide.

[0115] Figure 8 It is a schematic diagram showing the structure of an external cleaning mechanism according to a fifth embodiment.

[0116] like Figure 8As shown, the moving mechanism 13 has a slide 17M and a spring 16M. The slide 17M has a surface side for mounting the magnetic wiper 10 and a back side opposite to the surface side, and a track is provided on the surface side. In the magnetic wiper 10 composed of the external wiper 11 and the magnetic body 12, the surface of the magnetic body 12 opposite to the external wiper 11 is installed in the track on the surface side of the slide 17M so that the magnetic wiper 10 can move freely in the up and down direction. The back side of the slide 17M is fixed in the reaction tank via the spring 16M. In other words, one end of the spring 16M is fixed to the reaction tank, and the other end is fixed to the back side of the slide 17M.

[0117] The elastic force direction of the spring 16M, i.e., the X direction, is perpendicular to the extension direction of the slide 17M. The slide 17M extends in a direction parallel to the reaction tube. The lower end of the slide 17M contacts the bottom of the reaction tank and can slide in the X direction relative to the bottom of the reaction tank.

[0118] Figure 8 In the embodiment, two springs 16M are provided between the back side of the slideway 17M and the reaction tank, but the number is not limited thereto and can be adjusted according to actual needs. In addition, the type of the spring 16M is also not limited.

[0119] Figures 9A to 9C The moving process of the external cleaning mechanism according to the fifth embodiment from when the magnet enters the reaction tube to when it descends to the bottom is shown.

[0120] like Fig.9A As shown, when the external cleaning mechanism according to the fifth embodiment is used, when the magnet enters the reaction tube from above and the distance between the magnet and the magnetic body is greater than a predetermined distance, a fixed interval is maintained between the magnetic body and the outer wall of the reaction tube.

[0121] like Fig. 9B As shown in the figure, when the magnet enters the reaction tube and the distance between the magnet and the magnetic body is less than the specified distance, the magnetic body is attracted toward the reaction tube under the action of magnetic force, and the spring is stretched. At this time, since the magnetic body is fixed in the slideway, the slideway is also pulled toward the reaction tube in the direction of the arrow in the figure, and slides along the bottom of the reaction tank until the magnetic wiper touches the outer wall of the reaction tube.

[0122] Then, if Fig. 9C As shown, after the magnetic wiper contacts the outer wall of the reaction tube, the slideway remains fixed in the X direction and the spring remains stretched. At this time, the magnetic wiper outside the reaction tube moves in conjunction with the movement of the magnet, and can move in the up-down direction along the track on the surface side of the slideway to wipe the outer wall of the reaction tube.

[0123] Finally, when the magnet is removed from the reaction tube, the slideway and the magnetic wiper are restored to their initial positions together under the action of the restoring force of the spring.

[0124] By setting the above structure, when the magnet of the built-in cleaning mechanism enters the reaction tube, the magnetic body of the external cleaning mechanism can be attracted to the outer wall of the reaction tube by magnetic force, and as the magnet moves in the reaction tube, the outer wall of the reaction tube is wiped up and down. In addition, when the magnet of the built-in cleaning mechanism leaves the reaction tube, the external cleaning mechanism returns to its initial position separated from the outer wall of the reaction tube.

[0125] Therefore, the biochemical analysis device of the fifth embodiment can also wipe only the outer wall of the reaction tube that needs to be wiped, and not wipe the reaction tube that does not need to be wiped, thereby reducing the number of useless wiping times and increasing the service life of the reaction tube.

[0126] (Sixth Embodiment)

[0127] The sixth embodiment is the same as the fifth embodiment in that the slide is arranged near the magnetic wiper in order to ensure the strength of the external cleaning mechanism. The difference between the sixth embodiment and the fifth embodiment is that the moving mechanism of the sixth embodiment has a stopper in addition to the slide and the spring, and the stopper is fixed to the reaction tank instead of the spring.

[0128] Fig.10 It is a schematic diagram showing the structure of an external cleaning mechanism according to a sixth embodiment.

[0129] like Fig.10 As shown, the moving mechanism 13 includes: a slide 17C, a spring 16C and a block 18C, one end of the block 18C is fixed on the reaction tank, and the other end is connected to the slide 17C via the spring 16C and blocks the movement of the slide in the direction of the elastic force.

[0130] Specifically, the slide 17C has: a first portion 17C1 parallel to the reaction tube for the magnetic wipe 10 to be set, a second portion 17C2 connected to the spring 16C and limited by the stopper, and a third portion 17C3 connecting the first portion 17C1 and the second portion 17C2. The stopper 18C has a first portion 18C1 fixed to the reaction tank and perpendicular to the reaction tank and a second portion 18C2 connected to the spring 16C and parallel to the reaction tank. The spring 16C is set between the second portion 18C2 of the stopper and the second portion 17C2 of the slide, and the spring 16C is perpendicular to the second portion 17C2 of the slide relative to the second portion 18C2 of the stopper.

[0131] The first portion 17C1 of the slide has a track on the side opposite to the second portion 17C2 for the magnetic wiper 10 to be placed and slide, so that the magnetic wiper 10 can move up and down along the track.

[0132] Figures 11A to 11C The moving process of the external cleaning mechanism according to the sixth embodiment from when the magnet enters the reaction tube to when it descends to the bottom is shown.

[0133] like Fig.11A As shown, when the external cleaning mechanism involved in the sixth embodiment is used, when the magnet enters the reaction tube from above the reaction tube and the distance between the magnet and the magnetic body is greater than a predetermined distance, a fixed distance is maintained between the magnetic body and the outer wall of the reaction tube.

[0134] like Fig. 11B As shown in the figure, when the magnet enters the reaction tube and the distance between the magnet and the magnetic body is less than the specified distance, the magnetic body is attracted toward the reaction tube under the action of magnetic force. Since the magnetic body is fixed in the slideway, the entire slideway is also pulled toward the reaction tube in the direction of the arrow in the figure until the magnetic wiper touches the outer wall of the reaction tube. At this time, the spring is compressed between the second part of the stopper and the second part of the slideway.

[0135] Then, if Fig. 11C As shown in the figure, after the magnetic wiper contacts the outer wall of the reaction tube, the slideway remains fixed in the X direction and the spring remains compressed. At this time, the magnetic wiper outside the reaction tube moves in conjunction with the movement of the magnet, and can move in the up-down direction along the track on the surface side of the slideway to wipe the outer wall of the reaction tube.

[0136] Finally, when the magnet is removed from the reaction tube, the slideway and the magnetic wiper are restored to their initial positions together under the action of the restoring force of the spring.

[0137] Therefore, the biochemical analysis device of the sixth embodiment can also wipe only the outer wall of the reaction tube that needs to be wiped, and not wipe the reaction tube that does not need to be wiped, thereby reducing the number of useless wiping times and increasing the service life of the reaction tube.

[0138] (Seventh Embodiment)

[0139] In the first to sixth embodiments, the magnetic nozzle has a magnet and the magnetic wiper has a magnetic body. However, the magnetic nozzle may have a magnetic body and the magnetic wiper may have a magnet.

[0140] Fig.12 It is a schematic diagram showing the structure of a biochemical analysis device according to the seventh embodiment.

[0141] like Fig.12 As shown, in the magnetic nozzle of the built-in cleaning mechanism, a magnetic body is used instead of a magnet. Also, in the magnetic wiper of the external cleaning mechanism, a magnet is used instead of a magnetic body. However, in this case, it should be noted that in order to reliably generate magnetic force, the polarity of the magnet disposed on the front wall of the reaction tank and the polarity of the magnet disposed on the rear wall of the reaction tank need to be opposite. Fig.12 , the polarity of the magnet on the front wall of the reaction tank is shown as the N pole, and the polarity of the magnet on the rear wall of the reaction tank is the S pole, but the polarity of the magnet on the front wall may also be the S pole, and the polarity of the magnet on the rear wall may be the N pole.

[0142] By adopting the structure of the seventh embodiment, it is also possible to wipe only the outer wall of the reaction tube that needs to be wiped, and not to wipe the reaction tube that does not need to be wiped. Therefore, the number of useless wiping times can be reduced, and the service life of the reaction tube can be increased.

[0143] in addition, Fig.12 Although the same structure as the fifth embodiment is shown in the figure as an example, the structure in which the magnetic nozzle has a magnetic body and the magnetic wiper has a magnet can also be applied to the other embodiments described above.

[0144] (Eighth Embodiment)

[0145] Fig.13A A schematic plan view of a nozzle held by a holding mechanism according to an eighth embodiment is shown. Fig. 13B A schematic diagram showing the structure of a biochemical analysis device according to an eighth embodiment.

[0146] In the present embodiment as well, the external cleaning mechanism can be linked to the operation of one of the plurality of nozzles held by the holding mechanism to wipe the outer wall of the reaction tube.

[0147] In the eighth embodiment, the nozzles held by the holding mechanism include, in addition to the nozzles ① to ⑧ for cleaning and drying the inner wall of the reaction tube in the prior art, a nozzle for spraying water indicated by reference numeral ⑨. Nozzle ⑨ is one of the plurality of nozzles linked to the external cleaning mechanism.

[0148] Nozzles ① to ⑧ are arranged directly above the reaction tube and arranged side by side with each other, and can enter the interior of the reaction tube as needed. Nozzle ⑨ is not arranged side by side with nozzles ① to ⑧, and is not arranged directly above the reaction tube, but is arranged above the outer area of ​​the reaction tube, that is, arranged obliquely above the reaction tube. Nozzle ⑨ will not enter the interior of the reaction tube, but sprays water on the impeller from above the impeller in the external cleaning mechanism described later to rotate it. The nozzle ⑨ that does not enter the interior of the reaction tube is also called a water spray nozzle. In this embodiment, the external cleaning mechanism includes a first external cleaning mechanism and a second external cleaning mechanism. The first external cleaning mechanism includes a base, a rotating shaft, an impeller, and a first magnetic wiper. In the first external cleaning mechanism, the base is set to extend in the vertical direction and fixed in the reaction tank, but its form is not limited as long as it can play the role of fixing the rotating shaft and the impeller. From the inner wall of the reaction tank to the reaction tube, a base, a rotating shaft, an impeller, and a first magnetic wiper are arranged in sequence. The impeller is, for example, formed in a disc shape and fixed to the base via a rotating shaft. The impeller is located directly below the nozzle ⑨ and rotated by the water sprayed from the nozzle ⑨. The impeller is sandwiched between the base and the magnet. A first magnetic wiper is provided on the side of the impeller close to the reaction tube. The first magnetic wiper is sandwiched between the reaction tube and the impeller in a manner that the wiping surface contacts the reaction tube and the magnetic surface contacts the impeller. The first magnetic wiper is, for example, composed of a magnet and a wiper, and the wiper can be a brush or sponge that can perform a wiping function. When the impeller is impacted by the water flow and rotates, the magnet and the wiper mounted on the magnet are driven to rotate together. The length of the wiper is, for example, set to half the height of the outer wall of the reaction tube, so that the entire height area of ​​the reaction tube can be wiped when the wiper rotates.

[0149] In addition, the second external cleaning mechanism is arranged at a position opposite to the first external cleaning mechanism across the reaction tube. The second external cleaning mechanism includes a base, a rotating shaft, and a second magnetic wiper. In the second external cleaning mechanism, the base is arranged to be fixed in the reaction tank in an extending direction in the up-down direction, but its form is not limited as long as it can play the role of fixing the rotating shaft and the impeller. From the inner wall of the reaction tank to the reaction tube, the base, the rotating shaft, and the second magnetic wiper are arranged in sequence. Compared with the first external cleaning mechanism, the second external cleaning mechanism does not have an impeller, and the second magnetic wiper is fixed to the base of the reaction tank via the rotating shaft. That is, the second magnetic wiper is arranged at a position opposite to the first magnetic wiper across the reaction tube in a manner that the wiping surface contacts the reaction tube and the magnetic surface is fixed in the reaction tank. The second magnetic wiper is also composed of a magnet and a wiper, for example, and the wiper can be a brush or sponge that can play a wiping role.

[0150] The magnetism of the second magnetic wiper in the second external cleaning mechanism is opposite to that of the first magnetic wiper in the first external cleaning mechanism. When the magnetism of the first magnetic wiper is the N pole, the magnetism of the second magnetic wiper is the S pole, and when the magnetism of the first magnetic wiper is the S pole, the magnetism of the second magnetic wiper is the N pole. In addition, it is also possible to consider using a magnet in the first magnetic wiper and a magnetic body in the second magnetic wiper. In this case, there is no need to limit the magnetic poles of the magnet, and the second magnetic wiper can also rotate with the first magnetic wiper.

[0151] Since the polarities of the first magnetic wiper and the second magnetic wiper are opposite, when the first magnetic wiper rotates with the impeller, the second magnetic wiper rotates with the first magnetic wiper due to the effect of magnetic force, and wipes the outer wall of the reaction tube in a circular rotation. The wiper provided on the second magnetic wiper can be constructed in the same manner as the wiper provided on the first magnetic wiper.

[0152] Therefore, according to the present embodiment, the outer walls of the reaction tubes on both sides can be cleaned by spraying water only to one side of the external cleaning mechanism.

[0153] In addition, in this embodiment, the water in the flow path of the nozzle ⑨ can be controlled to be turned on and off. Therefore, the water in the flow path can be turned on only when the reaction tube that needs to be wiped reaches a specified position, so that the outer wall of the reaction tube is wiped. For the reaction tube that does not need to be wiped, the water in the flow path is not turned on, so that the outer wall of the reaction tube will not be wiped, which can reduce the number of useless wiping times and increase the service life of the reaction tube.

[0154] (Ninth Embodiment)

[0155] Fig.14A A schematic plan view of a nozzle held by a holding mechanism according to a ninth embodiment is shown. Fig. 14B A schematic diagram showing the structure of a biochemical analysis device according to a ninth embodiment.

[0156] In the first to eighth embodiments, the case where the outer wall of the reaction vessel is wiped using magnetic force is described. However, the outer wall of the reaction vessel may be wiped without using magnetic force.

[0157] In the present embodiment as well, the external cleaning mechanism can be linked to the operation of one of the plurality of nozzles held by the holding mechanism to wipe the outer wall of the reaction tube.

[0158] In the ninth embodiment, the external cleaning mechanism includes: a connecting plate, a guide groove, a chain and a wiper. The chain is a component that can move freely in the bent guide groove and exert a certain pushing force on the wiper. As an example, a hinge with deformation and recovery capabilities can be listed. In addition, it can also be a component other than a hinge that can be bent or folded, such as a titanium alloy material with elasticity. In addition, the chain can also be a material with a certain rigidity and a certain bending ability, such as a metal wire.

[0159] In the ninth embodiment, one of the plurality of nozzles arranged on the holding mechanism is a first nozzle located directly above the reaction tube and capable of entering and exiting the reaction tube in the up and down direction. The first nozzle is a nozzle linked to an external cleaning mechanism. In this embodiment, an example is given of a case where the first nozzle is a nozzle with a drying cotton installed below, and the reaction tube is dried when the first nozzle enters the reaction tube. However, as long as the first nozzle can be linked to an external cleaning mechanism, the first nozzle may also be a nozzle that performs other functions.

[0160] In addition to the plurality of nozzles arranged in a row, the holding mechanism is also provided with two connecting plates extending downward from the lower surface of the holding mechanism. The two connecting plates are arranged on opposite sides across the first nozzle on the holding mechanism. One end of a chain is respectively installed at the lower end of each connecting plate, and a wiping object is installed at the other end of the chain.

[0161] By arranging the two connecting plates and the first nozzle on the same plane, the external cleaning mechanism can wipe the outer wall of the reaction tube through which the first nozzle enters and exits in a linked manner based on the movement of the first nozzle. In other words, the movement of the first nozzle in and out of the reaction tube is used as the selection of the reaction tube that needs to be wiped, and the outer wall of the selected reaction tube is wiped with the wiper.

[0162] A guide groove is arranged inside the reaction tank to guide the movement trajectory of the chain and the wiper. The guide groove has an opening on one side opposite to the reaction tube, the chain is located inside the guide groove, and the wiper connected to the chain is located outside the guide groove and contacts the outer wall of the reaction tube. The wiper is sandwiched between the guide groove and the outer wall of the reaction tube, and is connected to the other end of the chain through the opening.

[0163] The lower part of the guide groove is configured to be closer to one side of the reaction tube than the upper part of the guide groove. The relative position of the lower part of the guide groove and the reaction tube determines the magnitude of the wiping force. When the lower part of the guide groove is close to the reaction tube, the pressing force is large. When the lower part of the guide groove is far away from the reaction tube, the pressing force is small. In order to wipe the outer wall of the reaction tube reliably, the distance between the lower part of the guide groove and the reaction tube should be less than the thickness of the wipe. In addition, the lower part of the guide groove extends a certain height in the up and down direction parallel to the reaction tube. The height is the range within which the wipe can wipe the reaction tube, which should meet the needs of light irradiation during biochemical analysis.

[0164] The upper part of the guide groove is arranged in the path through which the two connecting plates pass when they move up and down. When the connecting plates descend, the lower ends of the connecting plates enter the interior of the guide groove.

[0165] The middle part of the guide groove connects the lower part and the upper part of the guide groove, and is inclined from the side close to the reaction tube to the side away from the reaction tube, so that the wiped object after wiping can be restored from the squeezed state to the non-squeezed state and taken out from the upper part of the guide groove.

[0166] Figures 15A to 15C The operation mode of the biochemical analysis device according to the ninth embodiment is shown. The driving mechanism is, for example, a lifting mechanism, which can drive the first nozzle, the connecting plate, the chain and the wiper to move in the vertical direction.

[0167] Fig.15A The situation where the first nozzle enters the bottom of the reaction tube and the wipe is at the bottom outside the reaction tube is shown. Fig. 15B It shows the situation that the wiper is in the middle of the outside of the reaction tube as the first nozzle moves. Fig. 15C The diagram shows a situation where the first nozzle has not entered the interior of the reaction tube and the wiper is located at the upper portion of the outer side of the reaction tube.

[0168] When the lifting mechanism descends, Figure 15C to Figure 15A The wiper wipes from the upper part of the reaction tube to the lower part of the reaction tube in the order of Figures 15A to 15C The wiping object is used to wipe the reaction tube from the lower part to the upper part of the reaction tube in the order of the wiping object. According to the structure of the ninth embodiment, the outer wall of the reaction tank can be cleaned as the first nozzle enters the reaction tube. For the reaction tube that does not need to be wiped, since the built-in cleaning mechanism does not enter the reaction tube, the outer wall of the reaction tube will not be wiped, which can reduce the number of useless wiping times and increase the service life of the reaction tube.

[0169] Several variations of the biochemical analysis device have been described above, but the configurations shown in the above diagrams are merely illustrative and are not limited to the configurations of the biochemical analysis device shown in the diagrams. The combination of the components of the biochemical analysis device, the addition, omission or modification of the components, etc., are also included in the gist of the present invention. In addition, the reaction tube cleaning device composed of the internal cleaning mechanism and the external cleaning mechanism of each embodiment and its variations is also included in the gist of the present invention.

Claims

1. A biochemical analysis device, characterized in that: have: A reaction tube, used to contain a sample to be tested; a holding mechanism that holds the plurality of nozzles; and The external cleaning mechanism is arranged in the reaction tank and located outside the reaction tube. It is linked with the movement of one of the multiple nozzles held by the holding mechanism in the vertical direction in the reaction tube to wipe the outer wall of the reaction tube by moving up and down along the height direction of the outer wall of the reaction tube.

2. The biochemical analysis device according to claim 1, characterized in that: It also has a built-in cleaning mechanism. The built-in cleaning mechanism includes a magnetic nozzle, which is held by the holding mechanism and can move in and out of the reaction tube in the up and down directions under the drive of the driving mechanism, and the magnetic nozzle is one of the multiple nozzles. The external cleaning mechanism has a magnetic wiper. The built-in cleaning mechanism and the external cleaning mechanism attract each other under the action of magnetic force.

3. The biochemical analysis device according to claim 2, characterized in that: The magnetic nozzle has one of a magnet and a magnetic body, and is formed into a rod-shaped body extending in the vertical direction. The upper end of the magnetic nozzle is connected to the holding mechanism, and in the magnetic nozzle, one of the magnet and the magnetic body is located at the lower part of the magnetic nozzle.

4. The biochemical analysis device according to claim 3, characterized in that: The external cleaning mechanism also has a moving mechanism. The magnetic wiper is composed of an external wiper and the other of a magnet and a magnetic body. The moving mechanism is fixed to the reaction tank to hold the magnetic wiper. The external wiper of the magnetic wiper is disposed opposite to the outer wall of the reaction tube with a gap therebetween, and the other of the magnet and the magnetic body is located on the side of the external wiper opposite to the reaction tube. As the rod-shaped body moves in the reaction tube, the magnetic wiper is moved closer to the reaction tube under the action of magnetic force, and the moving mechanism causes the magnetic wiper to slide up and down along the outer wall of the reaction tube to wipe.

5. The biochemical analysis device according to claim 3, characterized in that: The built-in cleaning mechanism further includes a stopper that limits a trajectory of the magnetic nozzle moving in a vertical direction so that the magnetic nozzle does not tilt.

6. The biochemical analysis device according to claim 5, characterized in that: The limiting block is arranged on a part of the magnetic nozzle in a manner of covering the magnetic nozzle, and is made of a soft material. The size of the limiting block is smaller than or equal to the inner diameter of the reaction tube.

7. The biochemical analysis device according to claim 3, characterized in that: The built-in cleaning mechanism further includes another nozzle different from the magnetic nozzle for cleaning and drying the inner wall of the reaction tube.

8. The biochemical analysis device according to claim 3, characterized in that: The magnetic nozzle further includes a drying object, which is connected below one of the magnet and the magnetic body and moves up and down together with the magnet and the magnetic body under the drive of the drive mechanism to dry the inner wall of the reaction tube.

9. The biochemical analysis device according to claim 8, characterized in that: The built-in cleaning mechanism further includes another nozzle different from the magnetic nozzle for cleaning the inner wall of the reaction tube.

10. The biochemical analysis device according to any one of claims 1 to 9, characterized in that The external cleaning mechanism includes a plurality of external cleaning mechanisms, which are at least arranged on the front wall and the rear wall of the reaction tank to wipe the front surface and the rear surface of the reaction tube.

11. The biochemical analysis device according to claim 10, characterized in that: When the internal cleaning mechanism includes a magnetic body and the external cleaning mechanism includes a magnet, the magnet provided on the front wall of the reaction tank and the magnet provided on the rear wall of the reaction tank have opposite polarities.

12. The biochemical analysis device according to claim 4, characterized in that: The moving mechanism comprises: a first slider, a second slider, a spring and a slideway. The slide is fixed to the reaction tank. One end of the first slider is arranged in the slideway so as to be able to reciprocate along the extension direction of the slideway, and the other end of the first slider partially overlaps with one end of the second slider in the extension direction of the slideway and can slide relative to each other in a direction perpendicular to the extension direction. The one end of the second slider is connected to the slideway via the spring, and the other end of the second slider is connected to one of the magnet and the magnetic body.

13. The biochemical analysis device according to claim 4, characterized in that: The moving mechanism comprises: a slideway and a spring, One end of the spring is fixed to the reaction tank, and the other end is fixed to the back side of the slideway. The elastic force direction of the spring is perpendicular to the extension direction of the slideway. The slide extends in a direction parallel to the reaction tube, and the magnetic wiper is arranged in the slide and can reciprocate along the extending direction of the slide.

14. The biochemical analysis device according to claim 4, characterized in that: The moving mechanism comprises: a slideway, a spring and a stopper, One end of the stopper is fixed to the reaction tank, and the other end is connected to the slideway via the spring to block the movement of the slideway in the direction of the elastic force. The slideway comprises: a first part parallel to the reaction tube for setting the magnetic wiper, a second part connected to the spring and limited by the stopper, and a third part connecting the first part and the second part.

15. The biochemical analysis device according to claim 1, characterized in that: The one nozzle among the plurality of nozzles is a first nozzle located directly above the reaction tube and capable of entering and exiting the reaction tube in a vertical direction. The external cleaning mechanism comprises: a connecting plate, a guide groove, a chain and a wiper. The connecting plate is held by the holding mechanism and extends downward, is located on both sides of the first nozzle and is arranged on the same plane as the first nozzle, and has a lower end connected to the chain. The guide groove guides the movement of the chain. The wiper is connected to the lower end of the chain, sandwiched between the guide groove and the reaction tube, and wipes the outer wall of the reaction tube.

16. The biochemical analysis device according to claim 15, characterized in that: The guide groove is provided so that a distance between a lower portion and the reaction tube is smaller than that between an upper portion and the reaction tube, and the distance between the lower portion and the reaction tube is less than or equal to a thickness of the wipe.

17. A reaction tube cleaning device, characterized in that: have: a holding mechanism that holds the plurality of nozzles; and The external cleaning mechanism is arranged in the reaction tank of the biochemical analysis device and is located outside the reaction tube. It is linked with the movement of one of the multiple nozzles held by the holding mechanism in the vertical direction in the reaction tube to wipe the outer wall of the reaction tube by moving up and down along the height direction of the outer wall of the reaction tube.

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