Animal poison exposure system with medical nebulizer and experimental method

Abstract

An animal poison exposure system and experimental method with a medical nebulizer. The animal poison exposure system includes: an animal poison exposure tower, including a tower cavity defining a tower cavity, the tower cavity is provided with at least one opening; a connector, including a connector cavity defining a connector cavity, the connector cavity is connected to the tower cavity, the connector cavity is provided with at least one opening; at least one medical nebulizer, each of the medical nebulizers is fixed at the corresponding opening, and the liquid reaches the animal fixing tube after being atomized in the corresponding medical nebulizer. The experimental method includes: connecting at least one medical nebulizer to the animal poison exposure tower through a connector; adding liquid to all the medical nebulizers. This animal poison exposure system and experimental method with a medical nebulizer directly uses a medical nebulizer to administer drugs, which is closer to the actual concentration and aerosol particle size, and can more truly reflect the efficacy and toxicity of the drug.

Description

Technical Field

[0001] The present application relates to the field of biosafety technology, and in particular to an animal poison exposure system and experimental method with a medical nebulizer. Background Art

[0002] Since every drug has to go through a process from weak to strong, and from prosperous to declining, when old drugs decline, they must be replaced by new drugs. The launch of a new drug requires extremely rigorous safety evaluation experiments to clarify the efficacy and toxicity of the drug as much as possible. In addition to drugs, vaccines, new chemicals, etc. also require similar evaluations.

[0003] Although there are animal poison exposure systems and corresponding experimental methods in the relevant technology, such animal poison exposure systems and corresponding experimental methods in the relevant technology cannot truly reflect the efficacy and toxicity of the drug. Summary of the invention

[0004] In view of the above problems, the present application is proposed to provide an animal poison exposure system and experimental method with a medical nebulizer that overcomes the above problems or at least partially solves the above problems.

[0005] The present application first provides an animal poison exposure system, comprising: an animal poison exposure tower, comprising a tower cavity defining a tower cavity, the tower cavity being provided with at least one opening, each of the openings being used to connect an animal fixing cylinder for fixing an animal; a connector, comprising a connector cavity defining a connector cavity, the connector cavity being communicated with the tower cavity, the connector cavity being connected to the tower cavity, and the connector cavity being provided with at least one opening; at least one medical nebulizer, the at least one medical nebulizer corresponding one-to-one to the at least one opening, each of the medical nebulizers being fixed at the corresponding opening, each of the medical nebulizers being used to contain a liquid, the liquid being atomized in the corresponding medical nebulizer and then entering the connector cavity, the tower cavity, the at least one opening in sequence through the corresponding opening, and finally reaching the animal fixing cylinder.

[0006] Optionally, the at least one opening is evenly distributed at equal intervals.

[0007] Optionally, each of the medical nebulizers receives a high-pressure airflow through a connecting tube, a pressure reducing valve is provided on the connecting tube, and the animal poison exposure system further includes: a control system configured to control the air intake flow and pressure upstream of the medical nebulizer gas flow by adjusting the pressure reducing valve.

[0008] Optionally, each of the medical nebulizers is provided with a fluid infusion hole; and the animal poison exposure system further comprises: a peristaltic pump, connected to the fluid infusion hole via a fluid infusion tube, and the peristaltic pump is used to supply the liquid into the medical nebulizer through the fluid infusion tube and the fluid infusion hole.

[0009] Optionally, the control system is further configured to control the fluid replenishment rate of all the medical nebulizers through the peristaltic pump.

[0010] The present application also provides an animal poison exposure experiment method, comprising: connecting at least one medical nebulizer to an animal poison exposure tower through a connector, the animal poison exposure tower comprising a tower cavity defining a tower cavity, the tower cavity being provided with at least one opening, each of the openings being used to connect an animal fixing cylinder for fixing an animal, the connector comprising a connector cavity defining a connector cavity, the connector cavity being communicated with the tower cavity, the connector cavity being connected to the tower cavity, the connector cavity being provided with at least one opening, the at least one medical nebulizer corresponding one-to-one to the at least one opening, each of the medical nebulizer being fixed at the corresponding opening; adding liquid to all the medical nebulizers, the liquid being atomized in the corresponding medical nebulizer and then entering the connector cavity, the tower cavity, the at least one opening in sequence through the corresponding opening, and then reaching the animal fixing cylinder, so as to conduct a poison exposure experiment on the corresponding animal.

[0011] Optionally, the at least one opening is evenly distributed at equal intervals.

[0012] Optionally, each of the medical nebulizers receives a high-pressure airflow through a connecting tube, a pressure reducing valve is provided on the connecting tube, and the animal poison exposure experimental method further includes: adjusting the pressure reducing valve to control the air intake flow and pressure upstream of the gas flow of the medical nebulizer.

[0013] Optionally, each of the medical nebulizers is provided with a fluid infusion hole; and the animal poison exposure experimental method further comprises: using a peristaltic pump to supply the liquid into the medical nebulizer through a fluid infusion tube and the fluid infusion hole, and the peristaltic pump is connected to the fluid infusion hole through the fluid infusion tube.

[0014] Optionally, the animal poison exposure experimental method further comprises: controlling the fluid replenishment rate of all the medical nebulizers by the peristaltic pump.

[0015] The animal poison exposure system and experimental method with a medical nebulizer provided in the present application directly uses a medical nebulizer to administer drugs, which is closer to the actual concentration and aerosol particle size, and can more truly reflect the efficacy and toxicity of the drug. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Other objects and advantages of the present invention will become apparent from the following description of the present invention with reference to the accompanying drawings, which will help to provide a comprehensive understanding of the present invention.

[0017] Figure 1 This is a schematic diagram of the structure of the animal poison exposure system of the first embodiment of the present application;

[0018] Figure 2 is a schematic diagram of the arrangement of a medical nebulizer and connectors of an animal poison exposure system in some embodiments of the present application;

[0019] Figure 3 It is a structural schematic diagram of an animal poison exposure system according to a second embodiment of the present application;

[0020] Figure 4 It is a structural schematic diagram of the animal poison exposure system of the third embodiment of the present application;

[0021] Figure 5 It is a schematic diagram of the animal poison exposure experimental method in some embodiments of the present application.

[0022] In the figure, 10 is an animal poison exposure system, 100 is an animal poison exposure tower, 110 is a tower cavity, 200 is a connector, 210 is a connector cavity, 300 is a medical nebulizer, 400 is a pressure reducing valve, and 500 is a peristaltic pump. DETAILED DESCRIPTION

[0023] In order to make the purpose, technical solution and advantages of the present invention clearer, the technical solution of the present invention will be clearly and completely described below in conjunction with the accompanying drawings of the embodiments of the present invention. Obviously, the described embodiment is one embodiment of the present invention, not all embodiments. Based on the described embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0024] Unless otherwise defined, technical or scientific terms used in the present invention shall have the common meanings understood by one having ordinary skills in the field to which the present invention belongs.

[0025] The present application embodiment first provides an animal poison exposure system 10. Figure 1 is a structural schematic diagram of an animal poison exposure system 10 according to a first embodiment of the present application, Figure 2 Schematic diagram of the arrangement of the medical nebulizer 300 and the connector 200 of the animal poison exposure system 10 in some embodiments of the present application ( Figure 1 For the main view perspective, Figure 2 is the top view perspective, and Figure 2Only the medical nebulizer 300 and the connector 200 are shown. It can be understood that the drawings in this embodiment are only for schematic illustration, and the size ratio relationship of the components in each drawing does not constitute a limitation).

[0026] The present invention is mainly used for preclinical inhalation drug safety evaluation experiments and inhalation drug administration experiments of animals in biosafety laboratories. Since each drug must go through a process from weak to strong and from prosperous to declining. Then, when the old drug declines, it must be replaced by a new drug. The launch of a new drug needs to undergo extremely rigorous safety evaluation experiments to clarify the efficacy and toxicity of the drug as much as possible. Therefore, it is particularly important to use certain instruments and equipment to ensure the stable and efficient intake of drugs in preclinical animal experiments.

[0027] like Figure 1 as well as Figure 2 As shown, the animal poison exposure system 10 of the embodiment of the present application includes: an animal poison exposure tower 100, a connecting piece 200 and at least one medical nebulizer 300.

[0028] The animal poison exposure tower 100 includes a tower cavity 110 defining a tower cavity. The tower cavity 110 is provided with at least one opening, and each of the openings is used to connect an animal fixing cylinder for fixing an animal.

[0029] The animal fixator may include a piston and a sealed piston cylinder having a first opening and a second opening; the piston cylinder has a head accommodating chamber and a body accommodating chamber; the first opening is located on the end surface of the piston cylinder having the head accommodating chamber; the second opening is located on the end surface of the piston cylinder having the body accommodating chamber; the animal fixator also includes: a sealing device, which is arranged at the second opening. That is to say, the animal poison exposure system 10 of the embodiment of the present application can be an animal oral and nasal inhalation exposure system. Since the structure of the animal fixator itself is well known and easy to implement by those skilled in the art, it will not be described in detail here.

[0030] The connector 200 includes a connector cavity body 210 defining a connector cavity, the connector cavity is communicated with the tower cavity, the connector cavity body 210 is connected to the tower cavity body 110, and the connector cavity body 210 is provided with at least one opening.

[0031] The at least one medical nebulizer 300 corresponds to the at least one opening one by one, and each of the medical nebulizers 300 is fixed at the corresponding opening. Each of the medical nebulizers 300 is used to contain liquid (which may be various drugs, inhalation preparations, etc.). After being atomized in the corresponding medical nebulizer 300, the liquid enters the connector cavity, the tower cavity, the at least one opening in sequence through the corresponding opening, and then reaches the animal fixing cylinder.

[0032] The connector 200 may also be connected to clean air via a clean air pipe to mix or dilute the atomized liquid.

[0033] It can be understood that the medical nebulizer 300 refers to a nebulizer that has a therapeutic effect. For example, during treatment, the medical nebulizer 300 is connected to a compressor through a pipeline to receive compressed air. The medicine becomes mist in the medical nebulizer 300 and is then inhaled by the patient through a mouthpiece or a mask.

[0034] Specifically, the medical nebulizer 300 may include a nebulizer upper section, a nozzle attachment, and a nebulizer lower section.

[0035] The lower section of the atomizer includes a lower main cylinder, a partition, and an inner column. The partition divides the cylinder cavity defined by the lower main cylinder into two parts, the upper part of the cylinder cavity is used to contain liquid. There is an opening in the middle of the partition for placing the inner column. The inner column is a hollow structure with an upper opening and a lower opening. The first part of the inner column is located in the upper part of the cylinder cavity, and the second part is located in the lower part of the cylinder cavity. The lower opening of the inner column is connected to the high-pressure air pipe. The upper opening of the inner column is provided with a tapered part, which extends from bottom to top in a gradually contracting manner, and a tapered part hole is provided at the upper end, and a plurality of vertical protrusions are provided on the outer periphery of the first part of the inner column, and grooves are formed between adjacent protrusions.

[0036] The nozzle attachment includes an attachment main cylinder, which is connected to a sleeve. The sleeve includes a cylindrical sleeve and a conical sleeve located at the upper end of the cylindrical sleeve. The conical sleeve extends from bottom to top in a gradually contracting manner, and a conical sleeve hole is provided at the top of the conical sleeve. The sleeve is used to sleeve the first part of the inner column. A support rod is provided in the attachment main cylinder, which supports a connecting rod extending in the up-and-down direction. The connecting rod corresponds to the position of the conical sleeve hole, and the lower end of the connecting rod can be a sphere.

[0037] The upper section of the atomizer includes an upper section cylinder of the atomizer, which is threadedly connected to the lower section main cylinder and covers the nozzle attachment together with the lower section main cylinder. The side of the upper section cylinder of the atomizer is connected to the side cylinder, which is used to spray the atomized liquid and is used to connect with the connector 200. It can be understood that the upper section of the atomizer can also have a handle, a cover and other parts, which will not be repeated here.

[0038] When high-pressure airflow is introduced into the lower opening of the inner column of the lower section of the nebulizer, the airflow will flow out at a high speed from the nozzle (conical sleeve hole). At the same time, due to the siphon principle, the liquid contained in the lower section of the medical nebulizer 300 will also be adsorbed and flow out at a high speed with the airflow. There will be a sphere directly above the nozzle. When the airflow carrying the solution hits the sphere at high speed, high-concentration aerosol particles will be formed. Among them, large particles will settle into the solution in the lower section of the nebulizer due to gravity and continue to be adsorbed and repeatedly hit. Small particles will enter the upper section of the nebulizer with the rising airflow dispersed after the collision, forming an aerosol state with a stable concentration and follow the airflow through the air outlet connection port at the upper end of the nebulizer into the connector 200 at the rear end for standby use.

[0039] The animal poison exposure system 10 with a medical nebulizer 300 provided in the present application directly uses the medical nebulizer 300 to administer drugs, which is closer to the actual concentration and aerosol particle size, and can more truly reflect the efficacy and toxicity of the drug.

[0040] In some embodiments of the present application, the at least one opening is evenly distributed at equal intervals. Among them, the at least one opening can be 4 openings, that is, the connector 200 is evenly distributed in a cross shape to open four opposite air inlets (i.e., openings). Because the airflow ejected from the medical nebulizer 300 has a certain speed (about 0.3m / s), if it hits the side wall of the cavity or the side wall of the connector 200, it will cause particles to adhere to the wall, i.e., aerosol particles will be lost. The cross-shaped evenly distributed connection can enable the two corresponding medical nebulizers 300 to collide directly with each other without contacting the wall to reduce the speed, and because there is a continuous air extraction factor at the bottom, the airflow will flow to the lower part stably and evenly, which can reduce the particle loss caused by hitting the cavity wall.

[0041] Figure 3 It is a structural schematic diagram of the animal poison exposure system 10 of the second embodiment of the present application. In some embodiments, each of the medical nebulizers 300 receives a high-pressure airflow through a connecting pipe, and a pressure reducing valve 400 is provided on the connecting pipe. And the animal poison exposure system 10 also includes: a control system, which is configured to control the air intake flow rate and pressure upstream of the gas flow of the medical nebulizer 300 by adjusting the pressure reducing valve 400. In other words, this embodiment can control the front-end air intake flow rate and pressure by calculation. According to the material characteristics of the medical nebulizer 300, if the pressure of the front-end airflow is higher than 2.0 bar or the flow rate is higher than 5.0L / min, it may cause the material to be over-pressurized and the nozzle to rupture and deform, and thus the particle size of the atomized particles cannot be guaranteed to be stable. And according to the laws and regulations of the industry used, the front-end airflow pressure of such experimental instruments needs to be clearly known each time they are used, and the data is recorded and retained. Therefore, it is necessary to control the front-end pressure and airflow rate.

[0042] in, Figure 4is a schematic diagram of the structure of the animal poison exposure system 10 according to the third embodiment of the present application. Figure 4 As shown, each of the medical nebulizers 300 may be provided with a refilling hole. The animal poison exposure system 10 further includes a peristaltic pump 500, which is connected to the refilling hole through a refilling tube. The peristaltic pump 500 is used to supply the liquid into the medical nebulizer 300 through the refilling tube and the refilling hole. Since the medical nebulizer 300 generally has a volume limitation, a refilling hole is provided on the side of each medical nebulizer 300, and a quantitative peristaltic pump 500 is used to continuously and stably supply liquid, thereby making the medical nebulizer 300 more suitable for animal poison exposure experiments.

[0043] In some embodiments, the control system is further configured to control the rehydration rate of all the medical nebulizers 300 through the peristaltic pump 500. Specifically, the occurrence of all medical nebulizers 300 can be uniformly controlled by the computer through the solenoid valve, and the rehydration rate of all medical nebulizers 300 can be controlled by the peristaltic pump 500. Due to the volume limitation of the medical nebulizer 300, only 2-8 ml of solution can be injected at a time, and the single time can be used for up to 30 minutes, while the experimental conditions used by the industry generally use a duration of 2-6 hours, so it is necessary to use a peristaltic pump 500 to continuously rehydrate for long-term use. And due to the siphon principle, the height of the liquid level (when the volume of the lower section of the nebulizer is fixed, the amount of liquid determines the height of the liquid level) will affect the siphon speed, and then affect the atomization rate. In order to ensure the consistency of the atomization rate, it is necessary to control the peristaltic pump 500 to replenish the liquid evenly and stably, and keep it consistent with the atomization consumption, so as to keep the liquid level in the lower section of the nebulizer constant and the concentration of the atomized aerosol stable.

[0044] The animal poison exposure system 10 provided in the embodiment of the present application has a high drug utilization rate, which is more than 100% higher than the drug utilization rate of conventional animal experimental aerosol generators, reducing drug waste. And because it adopts medical equipment assembly line production, it has good consistency, high reliability, and is easy to replace and maintain. Since the medical nebulizer 300 is used directly to administer the drug, it is closer to the actual concentration and aerosol particle size, and can more truly reflect the efficacy and toxicity of the drug. The upper limit of the aerosol concentration is high, the experimental animals inhale more drugs per unit time, the animal anesthesia or fixation time is reduced, and the animal welfare is good.

[0045] It is understandable that the animal poison exposure system 10 provided in this embodiment may also have various frames, support structures, motors, calculators, etc., which will not be described in detail here.

[0046] The present application also provides an animal exposure test method. Figure 5 is a schematic diagram of the animal poison exposure experimental method of some embodiments of the present application, such as Figure 5As shown, the animal exposure test method includes:

[0047] Step S502: Connect at least one medical nebulizer 300 to the animal poison exposure tower 100 through the connector 200. The animal poison exposure tower 100 includes a tower cavity 110 defining a tower cavity, the tower cavity 110 is provided with at least one opening, each of the openings is used to connect an animal fixing cylinder for fixing an animal, the connector 200 includes a connector cavity 210 defining a connector cavity, the connector cavity is communicated with the tower cavity, the connector cavity 210 is connected to the tower cavity 110, the connector cavity 210 is provided with at least one opening, the at least one medical nebulizer 300 corresponds to the at least one opening one by one, and each of the medical nebulizers 300 is fixed at the corresponding opening;

[0048] Step S504: adding liquid into all the medical nebulizers 300. After being atomized in the corresponding medical nebulizer 300, the liquid sequentially enters the connector cavity, the tower cavity, the at least one opening through the corresponding openings and reaches the animal fixing cylinder to conduct a poison exposure experiment on the corresponding animal.

[0049] In some embodiments, the at least one opening is evenly distributed at equal intervals.

[0050] In some embodiments, each of the medical nebulizers 300 receives a high-pressure airflow through a connecting tube, a pressure reducing valve 400 is provided on the connecting tube, and the animal poison exposure experimental method further includes: adjusting the pressure reducing valve 400 to control the air intake flow and pressure upstream of the gas flow of the medical nebulizer 300.

[0051] In some embodiments, each of the medical nebulizers 300 is provided with a fluid infusion hole; and the animal poison exposure experimental method further includes: using a peristaltic pump 500 to supply the liquid into the medical nebulizer 300 through a fluid infusion tube and the fluid infusion hole, and the peristaltic pump 500 is connected to the fluid infusion hole through the fluid infusion tube.

[0052] In some embodiments, the animal poison exposure experimental method further includes: controlling the fluid replenishment rate of all the medical nebulizers 300 by the peristaltic pump 500 .

[0053] It can be understood that the specific structure and effects of each component corresponding to the animal poison exposure experimental method provided in this embodiment can refer to the previous embodiments and will not be repeated here.

[0054] Regarding the embodiments of the present invention, it should also be noted that, in the absence of conflict, the embodiments of the present invention and the features therein may be combined with each other to obtain new embodiments.

[0055] The above are only specific embodiments of the present invention, but the protection scope of the present invention is not limited thereto. The protection scope of the present invention shall be based on the protection scope of the claims.

Claims

1. An animal poison exposure system, comprising: An animal poison exposure tower comprises a tower cavity defining a tower cavity, wherein the tower cavity is provided with at least one opening, each of the openings being used to connect to an animal fixing cylinder for fixing an animal; the at least one opening is evenly distributed at equal intervals; A connector, comprising a connector cavity body defining a connector cavity, the connector cavity being in communication with the tower cavity, the connector cavity body being connected to the tower cavity, the connector cavity body being provided with at least one opening; The at least one opening is four openings, that is, the connecting piece has four openings evenly distributed in a cross shape; At least one medical nebulizer, the at least one medical nebulizer corresponds to the at least one opening one by one, each medical nebulizer is fixed at the corresponding opening, each medical nebulizer is used to contain liquid, and the liquid is atomized in the corresponding medical nebulizer and then enters the connector cavity, the tower cavity, the at least one opening in sequence through the corresponding opening and then reaches the animal fixing cylinder; The medical nebulizer includes an upper nebulizer section, a nozzle attachment, and a lower nebulizer section; The lower section of the atomizer includes a lower main cylinder, a partition, and an inner column. The partition divides the cylinder cavity defined by the lower main cylinder into two parts, the upper part of the cylinder cavity is used to contain liquid, and the middle of the partition has an opening for placing the inner column. The inner column is a hollow structure with an upper opening and a lower opening. The first part of the inner column is located in the upper part of the cylinder cavity, and the second part is located in the lower part of the cylinder cavity. The lower opening of the inner column is connected to the high-pressure air pipe. The upper opening of the inner column is provided with a tapered piece, which extends from bottom to top in a gradually contracting manner, and a tapered piece hole is provided at the upper end, and a plurality of vertical protrusions are provided on the outer periphery of the first part of the inner column, and grooves are formed between adjacent protrusions. The nozzle attachment includes an attachment main cylinder, the attachment main cylinder is connected to a sleeve, the sleeve includes a cylindrical sleeve and a conical sleeve located at the upper end of the cylindrical sleeve, the conical sleeve extends from bottom to top in a gradually contracting manner, and a conical sleeve hole is provided at the top of the conical sleeve, the sleeve is used to sleeve the first part of the inner column, a support rod is provided in the attachment main cylinder, the support rod supports a connecting rod extending in the up-and-down direction, the connecting rod corresponds to the position of the conical sleeve hole, and the lower end of the connecting rod is a sphere; The upper section of the atomizer includes an upper section cylinder of the atomizer, which is threadedly connected to the lower section main cylinder and covers the nozzle attachment together with the lower section main cylinder. The side of the upper section cylinder of the atomizer is connected to the side cylinder, which is used to spray the atomized liquid and is used to connect with the connecting piece. Each of the medical nebulizers receives a high-pressure airflow through a connecting tube, on which a pressure reducing valve is provided, and the animal poison exposure system further comprises: a control system configured to control the air intake flow and pressure upstream of the gas flow of the medical nebulizer by adjusting the pressure reducing valve.

2. The animal poison exposure system according to claim 1, wherein: Each of the medical nebulizers is provided with a rehydration hole; and the animal poison exposure system further comprises: A peristaltic pump is connected to the fluid infusion hole through a fluid infusion tube, and the peristaltic pump is used to supply the liquid into the medical nebulizer through the fluid infusion tube and the fluid infusion hole.

3. The animal poison exposure system according to claim 2, wherein: The control system is also configured to control the fluid replenishment rate of all the medical nebulizers through the peristaltic pump.

4. An animal poison exposure experimental method applied to the animal poison exposure system according to any one of claims 1 to 3, comprising: Connecting at least one medical nebulizer to an animal poison exposure tower through a connector, wherein the animal poison exposure tower comprises a tower cavity defining a tower cavity, wherein the tower cavity is provided with at least one opening, wherein each of the openings is used to connect an animal fixing cylinder for fixing an animal, wherein the connector comprises a connector cavity defining a connector cavity, wherein the connector cavity is communicated with the tower cavity, wherein the connector cavity is connected to the tower cavity, wherein the connector cavity is provided with at least one opening, wherein the at least one medical nebulizer corresponds to the at least one opening one by one, and each of the medical nebulizers is fixed at the corresponding opening; The at least one opening is evenly distributed at equal intervals; The at least one opening is four openings, that is, the connecting piece has four openings evenly distributed in a cross shape; The medical nebulizer includes an upper nebulizer section, a nozzle attachment, and a lower nebulizer section; The lower section of the atomizer includes a lower main cylinder, a partition, and an inner column. The partition divides the cylinder cavity defined by the lower main cylinder into two parts, the upper part of the cylinder cavity is used to contain liquid, and the middle of the partition has an opening for placing the inner column. The inner column is a hollow structure with an upper opening and a lower opening. The first part of the inner column is located in the upper part of the cylinder cavity, and the second part is located in the lower part of the cylinder cavity. The lower opening of the inner column is connected to the high-pressure air pipe. The upper opening of the inner column is provided with a tapered piece, which extends from bottom to top in a gradually contracting manner, and a tapered piece hole is provided at the upper end, and a plurality of vertical protrusions are provided on the outer periphery of the first part of the inner column, and grooves are formed between adjacent protrusions. The nozzle attachment includes an attachment main cylinder, the attachment main cylinder is connected to a sleeve, the sleeve includes a cylindrical sleeve and a conical sleeve located at the upper end of the cylindrical sleeve, the conical sleeve extends from bottom to top in a gradually contracting manner, and a conical sleeve hole is provided at the top of the conical sleeve, the sleeve is used to sleeve the first part of the inner column, a support rod is provided in the attachment main cylinder, the support rod supports a connecting rod extending in the up-and-down direction, the connecting rod corresponds to the position of the conical sleeve hole, and the lower end of the connecting rod is a sphere; The upper section of the atomizer includes an upper section cylinder of the atomizer, which is threadedly connected to the lower section main cylinder and covers the nozzle attachment together with the lower section main cylinder. The side of the upper section cylinder of the atomizer is connected to the side cylinder, which is used to spray the atomized liquid and is used to connect with the connecting piece. Each of the medical nebulizers receives a high-pressure airflow through a connecting tube, and a pressure reducing valve is provided on the connecting tube, and the animal poison exposure system further comprises: a control system configured to control the air intake flow rate and pressure upstream of the gas flow of the medical nebulizer by adjusting the pressure reducing valve; Each of the medical nebulizers receives a high-pressure airflow through a connecting tube, and a pressure reducing valve is provided on the connecting tube, and the animal poison exposure experimental method further comprises: adjusting the pressure reducing valve to control the air intake flow rate and pressure upstream of the gas flow of the medical nebulizer; Liquid is added into all the medical nebulizers. After being atomized in the corresponding medical nebulizer, the liquid enters the connector cavity, the tower cavity, the at least one opening in sequence through the corresponding openings and reaches the animal fixing cylinder to conduct a poison exposure experiment on the corresponding animal.

5. The animal poison exposure experimental method according to claim 4, wherein: Each of the medical nebulizers is provided with a rehydration hole; and the animal poisoning exposure experimental method further comprises: A peristaltic pump is used to supply the liquid into the medical nebulizer through a liquid infusion tube and the liquid infusion hole, and the peristaltic pump is connected to the liquid infusion hole through the liquid infusion tube.

6. The animal poison exposure experimental method according to claim 5, wherein: Also includes: The fluid replenishment rate of all the medical nebulizers is controlled by the peristaltic pump.

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