A material transmission structure and method for a radioactive drug production hot cell

Abstract

The present invention discloses a material transfer structure for a hot cell in the production of radioactive drugs, comprising a first shielding box, a first door provided on the top surface of the first shielding box, a second door provided on a side surface of the first shielding box, a sealing cover provided on a shielding container, the sealing cover being detachably connected to the first door, a first lifting mechanism provided in the production area for driving the first door and the sealing cover to rise and fall, and a second lifting mechanism provided in the first shielding box for driving the shielding container to rise and fall. The transfer method comprises the following steps: opening the second door, placing the shielding container into the first shielding box, and closing the second door; the second lifting mechanism driving the shielding container to rise, the first lifting mechanism driving the first door and the sealing cover to rise, removing the radioactive material from the shielding container or placing radioactive waste into the shielding container; the first lifting mechanism driving the first door and the sealing cover to descend, disconnecting the sealing cover from the first door, and the second lifting mechanism driving the shielding container to descend; and opening the second door to remove the shielding container.

Description

Technical Field

[0001] The present invention relates to food and medicine packaging equipment and a packaging method, and in particular to a material transmission structure and a transmission method for a radioactive medicine production hot cell. Background Art

[0002] Hot cells for radiopharmaceutical production provide shielding, sealing, ventilation, and isolation for the synthesis, activity testing, and packaging of radiopharmaceuticals. Due to the high radioactivity and volatility of radiopharmaceuticals, after producing a batch of drugs, they must be kept for several days or even weeks until the radioactivity has decreased to acceptable levels before they can be opened, which creates inconvenience. To reduce this holding time and improve production efficiency, a common practice is to add loading and unloading mechanisms to transfer production materials into the hot cell. Since hot cells typically operate in Class 100 or Class 1000 cleanrooms and the drugs are volatile, ensuring the sealing of the loading and unloading drawers is crucial to prevent damage to the hot cell environment during material transfer and to prevent the leakage of volatile drugs. Furthermore, ventilation systems are required to purify and ventilate the drawers to prevent volatile substances from entering the room and potentially harming operators.

[0003] Patent document CN211699739U discloses a dedicated inlet and outlet structure for radioactive protection hot cells. This structure uses sealed doors at both ends of the inlet and outlet drawers to ensure isolation between the hot cell and the room (factory or laboratory, etc.). The drawers are then ventilated through the incoming and outgoing air, reducing the risk of damage to the hot cell environment. However, the feed drawer can only be pulled back and forth. To retrieve materials from inside the hot cell, the operator needs to reach into the hot cell through the operating gloves on the hot cell shielding door, then reach down from inside the hot cell into the drawer to retrieve the materials, making it difficult to retrieve the materials. Furthermore, the air supply and exhaust vents are located on the same side, creating a ventilation dead zone and poor ventilation and purification effects. Summary of the Invention

[0004] The technical problem to be solved by the present invention is to overcome the deficiencies of the prior art and provide a material transfer structure for a radioactive drug production hot cell which has a simple structure, is easy to operate and is conducive to improving safety.

[0005] The present invention further provides a method for transporting the material transport structure of the radioactive drug production hot cell.

[0006] In order to solve the above technical problems, the present invention adopts the following technical solutions:

[0007] A material transfer structure for a hot chamber for producing radioactive drugs, the hot chamber comprising a production area and a radioactive material transfer area for transferring shielded containers, the material transfer structure comprising a first shielding box arranged in the radioactive material transfer area, a first box door for connecting to the production area being provided on the top surface of the first shielding box, a second box door being provided on a side surface of the first shielding box, a sealing cover being detachably connected to the first box door, a first lifting mechanism being provided in the production area for driving the first box door and the sealing cover to rise and fall, and a second lifting mechanism being provided in the first shielding box for driving the shielding container to rise and fall.

[0008] As a further improvement of the above technical solution: the sealing cover is provided with a magnetic part, the first box door is provided with an electromagnet, and the first lifting mechanism is connected to the first box door.

[0009] As a further improvement of the above technical solution: a support seat is provided in the first shielding box body, a sliding seat for transporting the shielding container is provided on the support seat, and the sliding seat is connected to the second box door.

[0010] As a further improvement of the above technical solution: the shielding container includes a lead barrel, a lead cover arranged on the lead barrel, and a stainless steel barrel arranged in the lead barrel, and the sealing cover is arranged on the stainless steel barrel.

[0011] As a further improvement of the above technical solution: a first door frame is provided at a position corresponding to the first shielding box body and the first box door, and a conical surface is adopted between the first door frame and the lead barrel.

[0012] As a further improvement of the above technical solution: the first lifting mechanism includes a sealing cover and a lifting cylinder arranged in the sealing cover, the piston rod of the lifting cylinder passes through the sealing cover, and a hole sealing ring and a dustproof sealing ring are provided between the sealing cover and the piston rod of the lifting cylinder.

[0013] As a further improvement of the above technical solution: the hot chamber also includes a non-radioactive material transfer area, which is arranged opposite to the radioactive material transfer area, and the non-radioactive material transfer area is provided with a second shielding box and a transfer box, the top surface of the second shielding box is provided with a third box door for connecting to the production area, a side surface of the second shielding box is provided with a fourth box door, a sliding mechanism for driving the transfer box in and out of the fourth box door is provided in the second shielding box, and a lifting mechanism for driving the transfer box in and out of the third box door is provided under the sliding mechanism.

[0014] As a further improvement of the above technical solution: the sliding mechanism includes guide rods arranged on both sides of the transmission box, two support plates arranged between the two guide rods, and push-pull handles connected to the two guide rods. The inner wall of the second shielding box is provided with guide rollers on the upper and lower sides of the guide rods. One end of the transmission box is arranged on one of the support plates, and the other end of the transmission box is arranged on the other support plate.

[0015] As a further improvement of the above technical solution: a mounting seat is provided on the bottom surface of the second shielding box, and the lifting mechanism includes a lifting cylinder provided on the mounting seat and a tray provided on the piston rod of the lifting cylinder.

[0016] As a further improvement of the above technical solution: the bottom surface of the second shielding box is connected to an air inlet duct, and one side surface of the second shielding box is connected to an air outlet duct, and an air inlet fan is provided on the air inlet duct and / or an air outlet fan is provided on the air outlet duct.

[0017] A method for transporting a material transport structure of a radiopharmaceutical production hot cell, comprising:

[0018] The external radioactive material is transferred to the liquid medicine synthesis area in the hot chamber: the radioactive material is placed in the shielding container, and then the second door is opened, the shielding container is placed in the first shielding box, and then the second door is closed. The second lifting mechanism drives the shielding container to rise to the first door, and the first lifting mechanism drives the first door and the sealing cover to rise, and the radioactive material in the shielding container is taken out to the liquid medicine synthesis area for synthesis of radioactive drugs. The first lifting mechanism drives the first door and the sealing cover to descend, so that the first shielding box and the shielding container are both in a closed state, and then the connection between the sealing cover and the first door is disconnected, the second lifting mechanism drives the shielding container to descend, and finally the second door is opened, the shielding container is taken out of the first shielding box, and then the second door is closed;

[0019] and / or the radioactive waste in the medicine liquid synthesis area in the hot chamber is transferred to the outside: open the second door, place the shielding container into the first shielding box, and then close the second door. The second lifting mechanism drives the shielding container to rise to the first door. The first lifting mechanism drives the first door and the sealing cover to rise, and the radioactive waste in the medicine liquid synthesis area is placed in the shielding container. The first lifting mechanism drives the first door and the sealing cover to descend, so that the first shielding box and the shielding container are both in a closed state. Then the connection between the sealing cover and the first door is disconnected, the second lifting mechanism drives the shielding container to descend, and finally the second door is opened, the shielding container is taken out of the first shielding box, and then the second door is closed.

[0020] Compared with the prior art, the advantages of the present invention are as follows: the material transfer structure of the radioactive drug production hot room disclosed by the present invention, the radioactive material in the room is first placed in the shielding container, and then the second box door is opened, the shielding container is placed in the first shielding box, and then the second box door is closed, and the second lifting mechanism drives the shielding container to rise to the first box door, and the first lifting mechanism drives the first box door and the sealing cover to rise. At this time, the first box door and the shielding container are both in the open state, and the radioactive material in the shielding container can be taken out to the production area for operations such as the synthesis of radioactive drugs, or the radioactive waste in the production area can be placed in the shielding container, and then the first lifting mechanism drives the first box door and the sealing cover to rise. The box door and the sealing cover descend, so that the first box door and the shielding container are both in a closed state, and then the connection between the sealing cover and the first box door is disconnected, and the second lifting mechanism can drive the shielding container to descend alone, and finally the second box door is opened, the shielding container is taken out of the first shielding box, and then the second box door is closed. The structure is simple and easy to operate. During the entire transmission process, at least one of the first box door and the second box door is in a closed state, which can effectively prevent radiation from the production area from entering the room through the first shielding box, and the radiation is transmitted in a straight line. Even if a small amount of radiation enters the first shielding box through the first box door, it is difficult to continue to be transmitted out from the second door, thereby ensuring the safety of the operator.

[0021] The present invention discloses a transmission method for a material transmission structure of a radioactive drug production hot room. During the entire transmission process, at least one of the first box door and the second box door is in a closed state, which can effectively prevent radiation or volatile gases in the production area from entering the room through the first shielding box body. In addition, the radiation is transmitted in a straight line. Even if a small amount of radiation enters the first shielding box body through the first box door, it is difficult to continue to be transmitted out from the second box door, thereby ensuring the safety of the operator. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 It is a structural schematic diagram of the first usage state of the material transmission structure of the radioactive drug production hot cell of the present invention.

[0023] Figure 2 It is a schematic diagram of the three-dimensional structure of the first shielding box in the present invention.

[0024] Figure 3 It is a schematic cross-sectional structural diagram of the first shielding box in the present invention.

[0025] Figure 4 yes Figure 3 A partial enlarged view of .

[0026] Figure 5 It is a structural schematic diagram of the shielding container in the present invention.

[0027] Figure 6 It is a schematic diagram of the three-dimensional structure of the second door in the present invention.

[0028] Figure 7 It is a structural diagram of the second usage state of the present invention.

[0029] Figure 8 It is a schematic diagram of the three-dimensional structure of the second shielding box in the present invention.

[0030] Figure 9 It is a schematic cross-sectional view of the transmission box of the present invention located at the third door.

[0031] Figure 10 It is a schematic cross-sectional view of the transmission box of the present invention located at the fourth door.

[0032] Figure 11 It is a schematic diagram of the three-dimensional structure of the sliding mechanism in the present invention.

[0033] Figure 12 It is a schematic cross-sectional structural diagram of the jacking mechanism in the present invention.

[0034] The numbers in the figure indicate: 1. First shielding box; 11. First box door; 12. Second box door; 13. Electromagnet; 14. Support seat; 15. Sliding seat; 16. First door frame; 2. Shielding container; 21. Sealing cover; 22. Magnetic member; 23. Lead barrel; 24. Lead cover; 25. Stainless steel barrel; 3. First lifting mechanism; 31. Sealing cover; 32. Lifting cylinder; 33. Sealing ring for hole; 34. Dustproof sealing ring; 4. Hot chamber; 41. Production area; 42. Radioactive material transfer area; 43. Non-radioactive material transfer area; 5. Second shielding box; 51. Third box door; 52. Fourth box door; 53. Guide roller; 54. Mounting seat; 55. Air inlet duct; 56. Air outlet duct; 57. Air inlet fan; 6. Transfer box; 7. Sliding mechanism; 71. Guide rod; 72. Support plate; 73. Push-pull handle; 8. Lifting mechanism; 81. Lifting cylinder; 82. Pallet; 9. Second lifting mechanism. DETAILED DESCRIPTION

[0035] The present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments.

[0036] See also Figures 1 to 6, the material transfer structure of the radioactive drug production hot chamber of this embodiment, the hot chamber 4 includes a production area 41 and a radioactive material transfer area 42 for transferring shielded containers 2 (for radioactive materials, they need to be placed in the shielded container 2 for transfer to ensure the safety of operators, which can be barrel-shaped containers, box-shaped containers, box-shaped containers, etc.), the material transfer structure includes a first shielding box 1 arranged in the radioactive material transfer area 42, the top surface of the first shielding box 1 is provided with a first box door 11 for connecting to the production area 41 (that is, the production area 41 is located above the radioactive material transfer area 42), a second box door 12 is provided on one side of the first shielding box 1, a sealing cover 21 is provided on the shielding container 2, and the sealing cover 21 is detachably connected to the first box door 11, the production area 41 is provided with a first lifting mechanism 3 for driving the first box door 11 and the sealing cover 21 to rise and fall, and a second lifting mechanism 9 is provided in the first shielding box 1 for driving the shielding container 2 to rise and fall.

[0037] The material transfer structure of the radioactive drug production hot room is as follows: the radioactive material in the room (such as a production plant or laboratory, etc.) is first placed in the shielding container 2, and then the second box door 12 is opened, the shielding container 2 is placed in the first shielding box 1, and then the second box door 12 is closed. The second lifting mechanism 9 drives the shielding container 2 to rise to the first box door 11, and the first lifting mechanism 3 drives the first box door 11 and the sealing cover 21 to rise. At this time, the first box door 11 and the shielding container 2 are both in the open state. The radioactive material in the shielding container 2 can be taken out to the production area 41 for operations such as the synthesis of radioactive drugs, or the radioactive waste in the production area 41 can be placed in the shielding container 2, and then the first lifting mechanism 3 drives the first box door 11 and the sealing cover 21 descends, so that the first door 11 and the shielding container 2 are both in a closed state, and then the connection between the sealing cover 21 and the first door 11 is disconnected, and the second lifting mechanism 9 can drive the shielding container 2 to descend alone, and finally open the second door 12, take the shielding container 2 out of the first shielding box body 1, and then close the second door 12. The structure is simple and easy to operate. During the entire transmission process, at least one of the first door 11 and the second door 12 is in a closed state, which can effectively prevent radiation from the production area 41 from entering the room through the first shielding box body 1, and the radiation is transmitted in a straight line. Even if a small amount of radiation enters the first shielding box body 1 through the first door 11, it is difficult to continue to be transmitted out from the second door 12, thereby ensuring the safety of the operator.

[0038] Furthermore, in this embodiment, a magnetic member 22 (e.g., a magnetic block, a magnetic plate, etc.) is provided on the sealing cover 21, an electromagnet 13 is provided on the first door 11, and the first lifting mechanism 3 is connected to the first door 11. When the second lifting mechanism 9 drives the shielding container 2 to rise to the first door 11, the electromagnet 13 is energized to generate an attractive force to attract the magnetic member 22, thereby establishing a connection between the sealing cover 21 and the first door 11. At this time, the first lifting mechanism 3 can drive the first door 11 to rise and separate from the first shielding box 1, and at the same time, the sealing cover 21 is separated from the shielding container 2. When the first lifting mechanism 3 drives the first door 11 and the sealing cover 21 to descend until the first door 11 seals the first shielding box 1, the electromagnet 13 is de-energized, and the force between the magnetic member 22 and the electromagnet 13 is no longer exerted, that is, the connection between the sealing cover 21 and the first door 11 is disconnected. The sealing cover 21 descends under its own weight to seal the shielding container 2, and then the second lifting mechanism 9 can drive the shielding container 2 to descend alone. This simple structure is convenient to use.

[0039] Furthermore, in this embodiment, a support seat 14 is provided in the first shielding box body 1, and a sliding seat 15 for transporting the shielding container 2 is provided on the support seat 14, and the sliding seat 15 is connected to the second box door 12. When the second box door 12 is opened, the sliding seat 15 can be synchronously pulled out of the first shielding box body 1, and correspondingly, when the second box door 12 is closed, the sliding seat 15 can be synchronously pushed into the first shielding box body 1. The support seat 14 can provide support for the sliding seat 15, and the two are in a sliding fit (for example, a slide rail fits with a slider, a pulley fits with a slide rail, etc.), with low friction resistance. The shielding container 2 can be placed on the sliding seat 15, so that the shielding container 2 can be very conveniently and labor-savingly entered and exited from the first shielding box body 1.

[0040] Furthermore, in this embodiment, the shielding container 2 includes a lead barrel 23, a lead cover 24 mounted on the lead barrel 23, and a stainless steel barrel 25 mounted within the lead barrel 23. The sealing cover 21 is mounted on the stainless steel barrel 25. The lead barrel 23 and the lead cover 24 cooperate to form a closed cavity, thereby shielding radioactive materials. The stainless steel barrel 25 and the sealing cover 21 cooperate to form a closed cavity, thereby preventing the leakage of volatile substances. The structure is simple and reliable. The lead cover 24 must be removed before the shielding container 2 is placed on the sliding seat 15.

[0041] Furthermore, in this embodiment, a first door frame 16 is provided at a position corresponding to the first door 11 of the first shielding box 1. A conical surface fits between the first door frame 16 and the lead drum 23. When the second lifting mechanism 9 drives the lead drum 23 upward to dock with the first door frame 16, the conical surface fit between the lead drum 23 and the first door frame 16 forms a good seal. When the sealing cover 21 and the first door 11 are raised, leakage of radioactive and volatile substances within the production area 41 and the lead drum 23 is prevented. No gas replacement operation is required within the first shielding box 1, resulting in a simple and reliable structure.

[0042] Furthermore, in this embodiment, the first lifting mechanism 3 includes a sealed housing 31 and a lifting cylinder 32 disposed within the sealed housing 31. The piston rod of the lifting cylinder 32 extends through the sealed housing 31, and a hole seal 33 and a dustproof seal 34 are disposed between the sealed housing 31 and the piston rod of the lifting cylinder 32. The placement of the lifting cylinder 32 within the sealed housing 31 and the provision of the hole seal 33 and the dustproof seal 34 between the sealed housing 31 and the piston rod of the lifting cylinder 32 help prevent contamination caused by the lifting cylinder 32, thereby maintaining a high level of cleanliness in the production area 41. The second lifting mechanism 9 may also utilize a pneumatic cylinder, an electric cylinder, a screw-nut pair, or the like to drive the lead barrel 23 up and down.

[0043] See also Figures 7 to 12 In this embodiment, the hot chamber 4 further includes a non-radioactive material transfer area 43, which is arranged opposite to the radioactive material transfer area 42 ( Figure 1 In the transmission area 43 of non-radioactive materials, a second shielding box 5 and a transmission box 6 are provided (for non-radioactive materials, there is no need to consider radiation shielding). A third door 51 for connecting to the production area 41 is provided on the top surface of the second shielding box 5. A fourth door 52 is provided on one side of the second shielding box 5. A sliding mechanism 7 for driving the transmission box 6 in and out of the fourth door 52 is provided in the second shielding box 5. A lifting mechanism 8 for driving the transmission box 6 in and out of the third door 51 is provided below the sliding mechanism 7.

[0044] The non-radioactive materials in the room are first placed in the transmission box 6, then the fourth box door 52 is opened, the transmission box 6 is placed on the sliding mechanism 7, and then the sliding mechanism 7 is pushed into the second shielding box 5, and finally the third box door 51 is closed. After the transmission box 6 is in place, the jacking mechanism 8 drives the transmission box 6 to rise to the third box door 51. At this time, the third box door 51 is opened, and the non-radioactive materials in the transmission box 6 can be taken out to the production area 41, or the non-radioactive waste in the production area 41 can be placed in the transmission box 6, then the third box door 51 is closed, the jacking mechanism 8 drives the transmission box 6 to descend, and finally the fourth box door 52 is opened, the sliding mechanism 7 is pulled out from the second shielding box 5, the transmission box 6 can be taken out, and then the fourth box door 52 is closed. The structure is simple and easy to operate, which helps to ensure the sealing of the non-radioactive material transmission area 43.

[0045] Furthermore, in this embodiment, the sliding mechanism 7 includes guide rods 71 ​​disposed on both sides of the transmission box 6, two support plates 72 disposed between the two guide rods 71 ​​(i.e., the two guide rods 71 ​​and the two support plates 72 form a rectangular structure), and a push-pull handle 73 connected to the two guide rods 71. Guide rollers 53 are provided on the upper and lower sides of the guide rods 71 ​​on the inner wall of the second shielding box 5. One end of the transmission box 6 is disposed on one of the support plates 72, and the other end of the transmission box 6 is disposed on the other support plate 72. The guide rollers 53 on the upper and lower sides of the guide rods 71 ​​provide support and position-limiting guidance for the guide rods 71. At the same time, the frictional resistance between the two is low, making it convenient to manually pull the sliding mechanism 7 and the transmission box 6 as a whole out of or into the second shielding box 5. The structure is simple and reliable.

[0046] Furthermore, in this embodiment, a mounting base 54 is provided on the bottom surface of the second shielding box 5. The lifting mechanism 8 includes a lifting cylinder 81 mounted on the mounting base 54 and a tray 82 mounted on the piston rod of the lifting cylinder 81. When the transport box 6 moves above the tray 82, the piston rod retracts and extends, driving the tray 82 and the transport box 6 upward and downward, resulting in a simple and reliable structure. Of course, in other embodiments, the lifting mechanism 8 may also employ an electric cylinder, a screw-nut pair, or the like to lift the transport box 6.

[0047] Furthermore, in this embodiment, the bottom surface of the second shielding box 5 is connected to an air inlet duct 55, and a side surface of the second shielding box 5 is connected to an air outlet duct 56. An air inlet fan 57 is provided on the air inlet duct 55. Clean gas is input into the second shielding box 5 through the air inlet duct 55, and volatile gas is discharged from the air outlet duct 56 at the same time. This can achieve the replacement of the gas in the second shielding box 5, ensure the high cleanliness inside the hot chamber 4, and prevent volatile gas from leaking into the room. The air inlet duct 55 and the air outlet duct 56 are respectively located on the bottom surface and the side surface, which helps to eliminate ventilation dead corners and ensure the replacement effect. The structure is simple and reliable. Of course, in other embodiments, an air outlet fan (not shown in the figure) can also be provided on the air outlet duct 56, or an air inlet fan 57 and an air outlet fan can be provided at the same time.

[0048] As a preferred embodiment, inflatable sealing rings are provided on the first shielding box 1 at positions corresponding to the first door 11 and the second door 12. When the first door 11 and the second door 12 are in a closed state, the inflatable sealing rings are inflated to ensure sealing; when the first door 11 and the second door 12 need to be opened, the inflatable sealing rings are exhausted; similarly, inflatable sealing rings are provided on the second shielding box 5 at positions corresponding to the third door 51 and the fourth door 52; O-rings can also be provided on the mounting seat 54 and the bottom surface of the second shielding box 5, and a hole sealing ring 33 and a dustproof sealing ring 34 can also be provided between the piston rod of the lifting cylinder 81 and the mounting seat 54 to prevent the lifting cylinder 81 from destroying the cleanliness inside the second shielding box 5.

[0049] The material transfer method of the above-mentioned radiopharmaceutical production hot cell comprises:

[0050] The external radioactive material is transferred to the liquid medicine synthesis area in the hot chamber 4: the radioactive material is placed in the shielding container 2, and then the second door 12 is opened, the shielding container 2 is placed in the first shielding box 1, and then the second door 12 is closed. The second lifting mechanism 9 drives the shielding container 2 to rise to the first door 11, and the first lifting mechanism 3 drives the first door 11 and the sealing cover 21 to rise, and the radioactive material in the shielding container 2 is taken out to the liquid medicine synthesis area for synthesis of radioactive drugs. The first lifting mechanism 3 drives the first door 11 and the sealing cover 21 to descend, so that the first shielding box 1 and the shielding container 2 are both in a closed state, and then the connection between the sealing cover 21 and the first door 11 is disconnected, the second lifting mechanism 9 drives the shielding container 2 to descend, and finally the second door 12 is opened, the shielding container 2 is taken out from the first shielding box 1, and then the second door 12 is closed;

[0051] And / or the radioactive waste in the medicine liquid synthesis area in the hot chamber 4 is transferred to the outside: open the second box door 12, put the shielding container 2 into the first shielding box body 1, and then close the second box door 12. The second lifting mechanism 9 drives the shielding container 2 to rise to the first box door 11. The first lifting mechanism 3 drives the first box door 11 and the sealing cover 21 to rise, and the radioactive waste in the medicine liquid synthesis area is placed in the shielding container 2. The first lifting mechanism 3 drives the first box door 11 and the sealing cover 21 to descend, so that the first shielding box body 1 and the shielding container 2 are both in a closed state. Then the connection between the sealing cover 21 and the first box door 11 is disconnected, the second lifting mechanism 9 drives the shielding container 2 to descend, and finally the second box door 12 is opened, the shielding container 2 is taken out from the first shielding box body 1, and then the second box door 12 is closed.

[0052] In this transmission method, during the entire transmission process, at least one of the first door 11 and the second door 12 is in a closed state, which can effectively prevent radiation or volatile gases in the production area 41 from entering the room through the first shielding box 1, and the radiation is transmitted in a straight line. Even if a small amount of radiation enters the first shielding box 1 through the first door 11, it is difficult to continue to be transmitted out from the second door 12, thereby ensuring the safety of the operator.

[0053] Although the present invention has been disclosed above with reference to preferred embodiments, this is not intended to limit the present invention. Any person skilled in the art can, without departing from the scope of the technical solution of the present invention, utilize the technical content disclosed above to make many possible changes and modifications to the technical solution of the present invention, or modify it into an equivalent embodiment with equivalent changes. Therefore, any simple modification, equivalent change, and modification made to the above embodiments based on the technical essence of the present invention without departing from the content of the technical solution of the present invention shall fall within the scope of protection of the technical solution of the present invention.

Claims

1. A material transfer structure for a radioactive drug production hot cell, wherein the hot cell (4) comprises a production area (41) and a radioactive material transfer area (42) for transferring shielded containers (2), characterized in that: The material transmission structure includes a first shielding box (1) arranged in a radioactive material transmission area (42), a first box door (11) for connecting to a production area (41) is opened on the top surface of the first shielding box (1), a second box door (12) is opened on one side of the first shielding box (1), a sealing cover (21) is provided on the shielding container (2), and the sealing cover (21) is detachably connected to the first box door (11), the production area (41) is provided with a first lifting mechanism (3) for driving the first box door (11) and the sealing cover (21) to rise and fall, and a second lifting mechanism (9) for driving the shielding container (2) to rise and fall is provided in the first shielding box (1); the shielding container (2) includes a lead barrel (23), a lead cover (24) arranged on the lead barrel (23), and a stainless steel barrel (25) arranged in the lead barrel (23), and the sealing cover (21) is provided on the lead barrel (23). The material transmission structure further comprises a second shielding box (5) and a transmission box (6), wherein the top surface of the second shielding box (5) is provided with a third box door (51) for connecting to the production area (41), and a side surface of the second shielding box (5) is provided with a fourth box door (52), and a sliding mechanism (7) for driving the transmission box (6) in and out of the fourth box door (52) is provided in the second shielding box (5), and a lifting mechanism (8) for driving the transmission box (6) in and out of the third box door (51) is provided below the sliding mechanism (7), and the sliding mechanism (7) comprises guide rods (71) provided on both sides of the transmission box (6) and a support plate (72) provided between the two guide rods (71), one end of the transmission box (6) is provided on one of the support plates (72), and the other end of the transmission box (6) is provided on the other support plate (72).

2. The material transfer structure of the radiopharmaceutical production hot cell according to claim 1, characterized in that: The sealing cover (21) is provided with a magnetic part (22), the first box door (11) is provided with an electromagnet (13), and the first lifting mechanism (3) is connected to the first box door (11).

3. The material transfer structure of the radiopharmaceutical production hot cell according to claim 1, characterized in that: A support seat (14) is provided in the first shielding box body (1), a sliding seat (15) for transmitting the shielding container (2) is provided on the support seat (14), and the sliding seat (15) is connected to the second box door (12).

4. The material transfer structure for a radiopharmaceutical production hot cell according to claim 1, characterized in that: A first door frame (16) is provided at a position corresponding to the first shielding box body (1) and the first box door (11), and a conical surface fit is adopted between the first door frame (16) and the lead barrel (23).

5. The material transfer structure of the radiopharmaceutical production hot cell according to claim 1, characterized in that: The first lifting mechanism (3) comprises a sealing housing (31) and a lifting cylinder (32) arranged in the sealing housing (31); the piston rod of the lifting cylinder (32) passes through the sealing housing (31); and a hole sealing ring (33) and a dustproof sealing ring (34) are provided between the sealing housing (31) and the piston rod of the lifting cylinder (32).

6. The material transfer structure for a radiopharmaceutical production hot cell according to any one of claims 1 to 5, characterized in that: The hot chamber (4) further comprises a non-radioactive material transfer area (43), the non-radioactive material transfer area (43) being arranged opposite to the radioactive material transfer area (42), and the second shielding box (5) and the transfer box (6) being arranged in the non-radioactive material transfer area (43).

7. The material transfer structure of the radiopharmaceutical production hot cell according to claim 6, characterized in that: The sliding mechanism (7) further comprises a push-pull handle (73) connected to two guide rods (71), the support plates (72) are provided with two pieces, and the inner wall of the second shielding box (5) is provided with guide rollers (53) on the upper and lower sides of the guide rods (71).

8. The material transfer structure of the radiopharmaceutical production hot cell according to claim 6, characterized in that: The bottom surface of the second shielding box (5) is connected to an air inlet duct (55), and one side surface of the second shielding box (5) is connected to an air outlet duct (56). An air inlet fan (57) is provided on the air inlet duct (55) and / or an air outlet fan is provided on the air outlet duct (56).

9. A method for transporting materials of a material transport structure of a radiopharmaceutical production hot cell according to any one of claims 1 to 8, characterized in that: include: The external radioactive material is transferred to the liquid medicine synthesis area in the hot chamber (4): the radioactive material is placed in the shielding container (2), then the second door (12) is opened, the shielding container (2) is placed in the first shielding box (1), and then the second door (12) is closed. The second lifting mechanism (9) drives the shielding container (2) to rise to the first door (11), the first lifting mechanism (3) drives the first door (11) and the sealing cover (21) to rise, and the radioactive material in the shielding container (2) is taken out to the liquid medicine synthesis area for synthesis of radioactive drugs. The first lifting mechanism (3) drives the first door (11) and the sealing cover (21) to descend, so that the first shielding box (1) and the shielding container (2) are both in a closed state, and then the connection between the sealing cover (21) and the first door (11) is disconnected. The second lifting mechanism (9) drives the shielding container (2) to descend, and finally the second door (12) is opened to take the shielding container (2) out of the first shielding box (1), and then the second door (12) is closed. The invention discloses a method for transmitting radioactive waste from the drug solution synthesis area in the hot chamber (4) to the outside: opening the second door (12), placing the shielding container (2) into the first shielding box (1), and then closing the second door (12); the second lifting mechanism (9) drives the shielding container (2) to rise to the first door (11); the first lifting mechanism (3) drives the first door (11) and the sealing cover (21) to rise, and places the radioactive waste from the drug solution synthesis area into the shielding container (2); the first lifting mechanism (3) drives the first door (11) and the sealing cover (21) to descend, so that the first shielding box (1) and the shielding container (2) are both in a closed state; then the connection between the sealing cover (21) and the first door (11) is disconnected; the second lifting mechanism (9) drives the shielding container (2) to descend; finally, the second door (12) is opened, the shielding container (2) is taken out of the first shielding box (1), and then the second door (12) is closed.

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