Personal evaporation device

Abstract

According to some embodiments, an apparatus configured to release at least one substance from a source material is provided, the apparatus including: a housing; a plurality of source material segments positioned at fixed locations relative to the housing; a plurality of air flow paths, each air flow path associated with at least one source material segment, each air flow path associated with at least one blocking element that prevents air flow through the path; and an actuator operatively coupled to the blocking element, the actuator configured to unblock the air flow path of at least one selected source material segment to allow air flow to reach and pass through the source material within the selected segment.

Description

[0001] This application is a divisional application of the patent application for invention titled "Personal Vaporization Device" with the application number 201780016292.X (PCT application number PCT / IL2017 / 050030), the filing date of January 11, 2017.

[0002] Cross - reference to related applications

[0003] This application claims the benefit of priority of U.S. Provisional Patent Application No. 62 / 277,060, filed on January 11, 2016, the content of which is incorporated herein by reference in its entirety. Technical field

[0004] Some embodiments of the present invention relate to the delivery of active substances by inhalation, and more specifically but not exclusively to the delivery of at least one active substance through a plurality of delivery events, in which a controlled portion of the source material is heated independently of other portions of the source material. Summary of the invention

[0005] According to aspects of some embodiments of the present invention, there is provided an apparatus configured to release at least one substance from a source material, the apparatus comprising: a housing; a plurality of source material segments positioned at fixed positions relative to the housing; a plurality of air flow paths, each air flow path associated with at least one of the source material segments, each air flow path associated with at least one blocking element that prevents air flow through the path; and an actuator operatively coupled to the blocking element, the actuator configured to unblock the air flow path of at least one selected source material segment to allow air flow to reach and pass through the source material within the segment. In some embodiments, each source material segment is associated with a dedicated heating element. In some embodiments, the heating element is configured to heat the source material to release at least one active substance. In some embodiments, the actuator is configured to electrically couple the heating element associated with the selected source material segment. In some embodiments, the geometry of the apparatus is selected such that air flowing through the selected source material segment does not affect the unselected segments. In some embodiments, the apparatus includes a controller programmed to coordinate the air flow through the at least one source material segment and the activation of the heating element associated with the at least one source material segment. In some embodiments, the apparatus is configured to allow the source material segments to be used in an order that does not depend on the spatial arrangement of the source material segments. In some embodiments, the blocking element includes a cover of the source material segment. In some embodiments, the actuator is configured to displace the cover to a position that allows air flow to reach and pass through the source material of the segment. In some embodiments, the actuator is configured to use magnetic attraction to displace the cover. In some embodiments, the apparatus includes a mouthpiece and at least one conduit for guiding the air flow through the heated source material segment towards the mouthpiece. In some embodiments, the plurality of source material segments are linearly arranged along a long axis, and the actuator is capable of sliding along the long axis. In some embodiments, the apparatus is an inhaler configured to deliver the at least one active substance to a user via inhalation. In some embodiments, the apparatus is configured to deliver at least one active substance through a plurality of delivery events, wherein, in each delivery event, a controlled dose of the active substance is delivered to the user. In some embodiments, the apparatus is a cartridge for use with an inhaler. In some embodiments, the source material segments are separated from each other by an airtight barrier. In some embodiments, the apparatus includes at least one common conduit extending along the source material segments. In some embodiments, the source material in at least one of the segments includes between 1-10% nicotine. In some embodiments, the layer of source material in each segment is no more than 1 mm thick. In some embodiments, different source material segments include different source materials.In some embodiments, the source material segments include different active materials or components of the active material. In some embodiments, the source material segments are arranged linearly in an array relative to each other. In some embodiments, the amount of the active material decreases along the long axis defined by the array. In some embodiments, the amount of the active material increases along the long axis defined by the array.

[0006] According to aspects of some embodiments of the present invention, there is provided a device configured to deliver, by inhalation, at least one active substance released from a source material, the device comprising: one or more source material segments in which the source material is protected by an air-impermeable sealant, the sealant including a control area for opening at least one opening through the sealant; a flow arrangement configured to direct an air flow through one or more of the segments to a user of the device; and an actuator aligned with the control area of the sealant and with the flow arrangement to selectively open the at least one opening through the sealant at the segment to allow air to flow through the source material. In some embodiments, the control area of the sealant is temperature-sensitive, and the actuator includes a heating element configured to heat the sealant to open the at least one opening. In some embodiments, the actuator includes an air flow element configured to apply pressure generated by inhalation to the control area of the sealant to open the at least one opening. In some embodiments, the actuator includes an electrode set configured to apply electrical power to the control area of the sealant to open the at least one opening. In some embodiments, the actuator includes a knife or a punch configured to perforate the control area of the sealant to open the at least one opening. In some embodiments, the device includes a power source. In some embodiments, the actuator is movable relative to the one or more source material segments. In some embodiments, the actuator is configured to slide, roll, and / or be dragged relative to the source material segment. In some embodiments, the device includes a progress indicator configured to indicate one or more of: the amount of source material segments used; the amount of remaining source material segments; the amount of source material remaining in the segment; all source material segments have been consumed; and a given portion of the source material segment has been used. In some embodiments, the device includes an elongated configuration, and the progress indicator is configured to move along at least a portion of the length of the device. In some embodiments, the longitudinal position of the progress indicator corresponds to the sequential position of the currently used source material segment. In some embodiments, the progress indicator is configured to move when a new source material segment is loaded, the loading being performed automatically and / or manually by the user. In some embodiments, the progress indicator includes one or more of a light indicating device and a color indicating device. In some embodiments, the source material segment is contained within a cartridge, the cartridge being received within the inhaler. In some embodiments, a plurality of source material cartridges are received within the inhaler.

[0007] In accordance with aspects of some embodiments of the present invention, there is provided a source material cartridge configured to be used with an inhaler device, the cartridge comprising: one or more segments comprising a source material; the source material comprising at least one active substance capable of being released by evaporation, the source material being arranged to allow an air flow to pass therethrough; wherein the source material is protected by an air-impermeable sealant comprising a control region that is mechanically sensitive and / or temperature sensitive to open at least one opening through the sealant during use of the inhaler device to allow air flow through the source material of one or more selected segments to deliver the at least one active substance to a user. In some embodiments, the sealant is configured to open the at least one opening due to being heated. In some embodiments, the sealant is configured to heat the source material. In some embodiments, the cartridge comprises only one source material segment formed as an elongated tray, and wherein the amount of active substance released from the portion is set by controlling the air flow to at least a portion of the tray. In some embodiments, the cartridge comprises a plurality of source material segments separated from each other by at least one of a thermal insulator and an electrical insulator. In some embodiments, when the cartridge comprises one or more conduits, air entraining the drug flows through the conduits to be delivered to the user such that when the cartridge is received in the inhaler, air entraining the drug only flows through the cartridge, thereby eliminating residues in the inhaler.

[0008] In accordance with aspects of some embodiments of the present invention, there is provided a device configured to deliver at least one substance released from a source material to a user, the device comprising: a frame comprising one or more source material segments; a mouthpiece component; and a conduit configured to conduct the substance through at least one of the segments to the user, the conduit extending between at least one of the source material segments and the mouthpiece component. In some embodiments, the frame is shaped and sized to engage an inhaler device. In some embodiments, the at least one source material segment and the conduit are sealed such that only the air flow is allowed to flow through the at least one segment and the conduit.

[0009] In aspects according to some embodiments of the present invention, there is provided an apparatus configured to deliver at least one active substance released from a source material by inhalation, the apparatus comprising: a substrate including a plurality of slots, each slot containing the source material, each slot being associated with a dedicated air flow path; a movable actuator capable of being positioned to unblock the air flow path once aligned with an opening of the air flow path to provide an air flow of the source material through at least one selected slot. In some embodiments, the apparatus further includes a heating element associated with each of the source material slots, and a circuit that electrically couples the heating element to a power source when the actuator moves. In some embodiments, the actuator is a rotatable actuator. In some embodiments, the substrate includes a PCB.

[0010] In aspects according to some embodiments of the present invention, there is provided an inhaler device configured to deliver at least one substance released from a source material to a user, the device comprising: one or more source material segments arranged along a longitudinal axis; a slidable actuator configured to slide automatically or manually along the longitudinal axis to actuating the release of the at least one substance from at least one source material segment. In some embodiments, the slidable actuator is configured to unblock at least one air flow path associated with at least one source material segment. In some embodiments, the slidable actuator is configured to activate a heating element associated with at least one source material segment.

[0011] In aspects according to some embodiments of the present invention, there is provided a source material cartridge, the cartridge comprising: one or more sealed segments including the source material; a carrier conduit for conducting an air flow to at least one unsealed source material segment; and a bypass conduit that does not pass through the source material segment, wherein the flow through the bypass conduit is regulated in response to the flow through the carrier conduit.

[0012] According to aspects of some embodiments, there is provided an inhaler device configured to deliver at least one substance released from a source material to a user, the device being configured to receive a plurality of cartridges, each cartridge including a plurality of source material segments, the device including a controller configured to process at least one source material segment of at least one of the plurality of cartridges according to a predetermined scenario and to actuating the delivery of at least one substance released from the at least one source material segment to the user. In some embodiments, once the plurality of cartridges are received in the inhaler, the cartridges remain stationary and do not move relative to each other, even during use. In some embodiments, the plurality of source material segments of a single cartridge remain stationary and do not move relative to each other, even during use. In some embodiments, the controller is configured to process at least one source material segment according to the user's needs. In some embodiments, the plurality of cartridges contain different source materials or their components. In some embodiments, the plurality of source material segments in a single cartridge contain different source materials or their components.

[0013] In aspects according to some embodiments of the present invention, there is provided an apparatus configured to deliver, by inhalation, at least one active substance released from a source material by evaporation. The apparatus includes: a receptacle configured to receive at least one cartridge, the cartridge including one or more source material segments, wherein the source material is protected by an air-impermeable sealant including a control region for opening at least one opening through the sealant; a flow arrangement configured to direct an air flow through one or more selected segments and to a user of the apparatus when the cartridge is received within the receptacle; and an actuator aligned with the control region of the sealant and with the flow arrangement to open the at least one opening through the sealant at the selected segment to allow air to flow through the source material. In some embodiments, the control region of the sealant is temperature-sensitive and the actuator includes a heating element configured to heat the sealant to open the at least one opening. In some embodiments, the heating element is configured to heat the source material to evaporate at least one active substance. In some embodiments, the actuator includes an air flow element configured to apply pressure generated by inhalation to the control region of the sealant to open the at least one opening. In some embodiments, the actuator includes an electrode set configured to apply electrical power to the control region of the sealant to open the at least one opening. In some embodiments, the actuator includes a blade or a punch configured to perforate the control region of the sealant to open the at least one opening. In some embodiments, the apparatus includes a power source. In some embodiments, the actuator is movable relative to one or more source material segments of the cartridge. In some embodiments, the actuator is configured to slide, roll, and / or be dragged relative to the source material segments. In some embodiments, the apparatus is configured to deliver at least one active substance through a plurality of delivery events, wherein, in each delivery event, a controlled dose of the active substance is delivered to the user. In some embodiments, the apparatus includes a progress indicator configured to indicate one or more of: the amount of source material used; the amount of source material remaining; all source material segments have been consumed; and a given portion of the source material has been used. In some embodiments, the apparatus includes an elongated configuration and the progress indicator is configured to move along at least a portion of the length of the apparatus. In some embodiments, the longitudinal position of the progress indicator corresponds to the sequential position of the currently used source material segment. In some embodiments, the progress indicator is configured to move upon loading a new source material segment, the loading being performed automatically and / or manually by the user. In some embodiments, the progress indicator includes one or more of a light indicating device and a color indicating device.

[0014] In aspects of some embodiments of the present invention, there is provided a source material cartridge configured to be used with an evaporation device, the cartridge comprising: one or more segments including a source material, the segments being separated from each other by a thermal insulator and / or an electrical insulator; the source material including at least one active substance capable of being released by evaporation; the source material being arranged to allow an air flow to pass therethrough; wherein, in each of the segments, the source material is protected by an air-impermeable sealant including a control region that is mechanically sensitive and / or temperature sensitive so as to open at least one opening through the sealant during use of the evaporation device to allow air to flow through the source material of one or more selected segments to deliver the at least one active substance to a user of the evaporation device. In some embodiments, the sealant is configured to be heated to open the at least one opening. In some embodiments, the sealant is configured to heat the source material. In some embodiments, the sealant is a foil including a resistive substance, the sealant being a conductive foil configured to heat the source material when an electric current is applied to the foil. In some embodiments, the sealant includes a shape memory material, such as but not limited to a shape memory polymer that deforms in response to heat thereby allowing access to the source material. In some embodiments, one or more springs and / or other mechanisms are used to return the sealant to a closed position when the heating process ends. Additionally or alternatively, the sealant includes a shape memory material having a two-way shape memory effect. In some embodiments, the sealant includes and / or is connected to a shape memory material, such as but not limited to a shape memory alloy such as nitinol, copper-aluminum-zinc, or others. In some embodiments, the sealant includes stainless steel. In some embodiments, the sealant is configured to be resealed after the source material has been used. In some embodiments, the source material segments are arranged to be unsealed in a sequential manner. In some embodiments, the source material segments include an amount of source material that is sufficient to deliver a single dose of the active substance when evaporated. In some embodiments, the source material includes tobacco..

[0015] In accordance with aspects of some embodiments of the present invention, there is provided a method for delivering, by inhalation, at least one active substance released from a source material by evaporation of the source material, the method comprising: providing a source material sealed by an air-impermeable sealant; opening at least one opening in the sealant by at least one of heating the sealant and applying a mechanical force to the sealant to allow air to pass through the source material; directing an air flow through the source material and simultaneously heating the source material; and delivering, by inhalation, a vapor of the active substance to a user. In some embodiments, the method further comprises aligning an actuator with the sealant and the air flow, the actuator being configured to open at least one opening in the sealant. In some embodiments, at least one of opening, directing the air flow, and heating is initiated in response to inhalation by the user. In some embodiments, directing comprises dynamically moving an element configured to direct the air flow across the source material.

[0016] In accordance with aspects of some embodiments of the present invention, there is provided a source material cartridge for use with an evaporation device, the cartridge comprising:

[0017] a cartridge comprising one or more source material segments;

[0018] a mouthpiece component; and

[0019] a conduit configured to conduct a vapor flow, the conduit extending between the cartridge and the mouthpiece component.

[0020] In accordance with aspects of some embodiments of the present invention, there is provided a source material cartridge for use with an evaporation device, the cartridge comprising: a cartridge comprising one or more source material segments; and a conduit configured to conduct a vapor flow, the conduit being configured to extend between the cartridge and the mouthpiece of the device when used with the evaporation device.

[0021] In accordance with aspects of some embodiments of the present invention, there is provided a device configured to deliver, by inhalation, at least one active substance released by evaporation from a source material, the device comprising: a receptacle configured to receive at least one cartridge comprising a plurality of source material segments; a heating element configured to individually heat each of the source material segments; and a flow arrangement configured to move along the cartridge to selectively direct an air flow through one or more of the source material segments when the segments are heated to deliver, by inhalation, air entraining the active substance to a user.

[0022] According to aspects of some embodiments, a method of delivering at least one substance released from a source material to a user is provided. The method includes: selecting at least one source material segment from a plurality of source material segments; creating an air flow path between the selected source material segment and an output to the user such that each source material segment is associated with at least one air flow path. In some embodiments, creating the air flow path includes modifying the state of at least one air flow path associated with at least one selected source material segment from a state that does not allow air flow through the path to a state that allows at least some air flow through the path. In some embodiments, creating the air flow path includes removing an obstruction from at least one air flow path. In some embodiments, modifying the state of the air flow path is reversible. In some embodiments, the method further includes: releasing at least one substance from the source material via the air flow; and delivering the air flow to the user's mouth after the air flow has entrained the substance. In some embodiments, releasing at least one substance includes electrically coupling a heating element associated with at least one source material segment to heat the source material within the segment. In some embodiments, the timing of the electrical coupling is selected based on the timing of creating the air flow path. In some embodiments, a subset of at least two source material segments is selected from the plurality of source material segments.

[0023] According to aspects of some embodiments of the present invention, a source material cartridge configured to be used with an inhaler device is provided. The cartridge includes: one or more segments including a source material, the segments being separated from each other by at least one of a thermal insulator and an electrical insulator, the source material including at least one active substance capable of being released by evaporation; the source material being arranged to allow air flow therethrough; and wherein, in each segment, the source material is protected by an air-impermeable sealant including mechanically sensitive and / or temperature-sensitive control regions to open at least one opening through the sealant during use of the inhaler device to allow air to flow through the source material of one or more selected segments to deliver at least one active substance to the user. In some embodiments, the sealant is configured to open at least one opening due to being heated. In some embodiments, the sealant is configured to heat the source material. In some embodiments, the sealant is a foil including a resistive substance, the foil being configured to heat the source material when an electric current is applied to the foil. In some embodiments, the sealant includes a shape memory material. In some embodiments, the sealant includes stainless steel. In some embodiments, the sealant is configured to reseal after the source material has been used.

[0024] In some embodiments, the segments of the source material are arranged to be unsealed in a sequential manner. In some embodiments, the source material includes a bioactive plant. In some embodiments, the source material includes tobacco.

[0025] In accordance with aspects of some embodiments of the present invention, there is provided a method for delivering at least one active substance released from a source material by inhalation, the method comprising: providing a source material sealed by an air-impermeable sealant; opening at least one opening in the sealant by at least one of heating the sealant and applying a mechanical force to the sealant to allow air to pass through the source material; directing an air stream through the source material and heating the source material simultaneously; and delivering a vapor of the active substance to a user by inhalation. In some embodiments, the method further comprises: aligning an actuator with the sealant and the air stream, the actuator being configured to open at least one opening in the sealant. In some embodiments, at least one of opening, directing the air stream, and heating is initiated in response to inhalation by the user. In some embodiments, directing comprises: dynamically moving an element configured to direct the air stream to the source material across the source material.

[0026] In accordance with aspects of some embodiments of the present invention, there is provided an apparatus configured to deliver at least one substance released from a source material to a user, the apparatus comprising: at least one source material section at least partially sealed by a fluid that changes its viscosity in response to a temperature change; an air flow path associated with at least one of the source material sections; a heating element configured to heat the fluid; and one or more chambers that allow the fluid to flow into the chambers when the viscosity of the fluid decreases in response to heating, thereby exposing at least a portion of the source material to the air flow. In some embodiments, the fluid comprises silicone oil.

[0027] In accordance with aspects of some embodiments of the present invention, there is provided an apparatus configured to deliver at least one active substance released from a source material by inhalation, the apparatus comprising: a plurality of receptacles configured to receive a plurality of cartridges respectively, each cartridge comprising one or more source material sections; a flow arrangement configured to direct an air stream through one or more of the sections and to a user of the apparatus when the cartridge is received within the receptacle; and an actuator configured to selectively access one or more of the source material sections based on the contents of the source material sections. In some embodiments, the cartridge selected from the plurality of cartridges comprises source material sections that differ in at least one of: the amount of active substance, the type of active substance, the type of source material, or the type of source material composition. In some embodiments, the plurality of cartridges differ from each other in at least one of: the amount of active substance, the type of active substance, the type of source material, or the type of source material composition. In some embodiments, the apparatus comprises a plurality of source material sections.

[0028] According to aspects of some embodiments of the present invention, there is provided an apparatus configured to deliver, by inhalation, at least one active substance released from a source material by evaporation. The apparatus includes: a receptacle configured to receive at least one cartridge including a plurality of source material segments; a heating element configured to individually heat each of the source material segments; and a flow arrangement configured to move along the cartridge to selectively direct an air flow through one or more of the source material segments when the segments are heated, to deliver, by inhalation, air entraining the active substance to a user.

[0029] Unless otherwise defined, all technical and / or scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terms "example", "exemplary" and "for example" are used herein to mean "serving as an example, instance, or illustration". Any embodiment described as "example" or "exemplary" is not necessarily to be construed as preferred or advantageous over other embodiments and / or to exclude combinations of features from other embodiments. Although methods and materials similar or equivalent to those described herein can be used in the practice or testing of embodiments of the present invention, exemplary methods and / or materials are described below. In case of conflict, the present patent application document (including definitions) shall prevail. In addition, the materials, methods, and examples are illustrative only and not intended to be necessarily limiting. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] Some embodiments of the present invention are described herein by way of example only with reference to the drawings. Now, with particular reference to the drawings in detail, it should be emphasized that the details shown are by way of example and for the purpose of illustrative discussion of embodiments of the present invention. In this regard, the description taken in conjunction with the drawings makes it apparent to those skilled in the art how embodiments of the present invention may be practiced.

[0031] In the drawings:

[0032] Figure 1A is a flow chart of a general method of operation of an apparatus configured to deliver at least one active substance to a user by inhalation according to some embodiments of the present invention;

[0033] Figure 1B is a schematic view of an apparatus configured to provide at least one active substance by inhalation according to some embodiments of the present invention;

[0034] FIGS. 2A - C illustrate three configurations of the connection between the source material and the heating element according to some embodiments of the present invention;

[0035] Figure 3 illustrates a configuration according to some embodiments of the present invention, in which the heating element is movable relative to the source material;

[0036] Figure 4A -C shows a method and / or structure for dynamically changing the air permeability of a heating element and / or a sealant of a source material according to some embodiments of the present invention;

[0037] Figure 5A -B shows two flow patterns according to some embodiments of the present invention, in which an air flow is directed through a source material for transporting air entraining an active substance to a user;

[0038] Figure 6A -C shows a mechanism for moving an air flow element along a source material according to some embodiments of the present invention;

[0039] Figure 7 Schematically shows a dynamic air flow element according to some embodiments of the present invention, which is configured to direct air through a selected section of a source material;

[0040] Figure 8A -B shows the operation of a device including a plurality of air flow elements according to some embodiments of the present invention;

[0041] Figure 9 Schematically shows a heating element and / or a sealant according to some embodiments, which is configured to allow an air flow through a currently heated section of a source material and block the flow through an unheated section of the source material;

[0042] Figure 10A -F shows a cigarette device including a cylindrical configuration according to some embodiments of the present invention;

[0043] Figure 11A -C shows various disposable and / or replaceable components of a device according to some embodiments of the present invention;

[0044] Figure 12A -E are various views of a flat rectangular device according to some embodiments of the present invention;

[0045] Figure 13A -B shows a device including a usage progress indicator according to some embodiments of the present invention, such as the device shown in Figure 12A -E;

[0046] Figure 14 is a flowchart of a general method for delivering at least one substance released from a source material to a user according to some embodiments of the present invention;

[0047] Figure 15A -B schematically shows selectively removing a blockage of an air flow path associated with a selected section of a source material according to some embodiments of the present invention;

[0048] Figure 16A -B shows an arrangement of source material segments configured to provide individual access to each of a plurality of source material segments, according to some embodiments of the present invention;

[0049] Figure 17A -B shows a slidable actuator, according to some embodiments of the present invention, configured to unblock at least one air flow path associated with at least one source material segment and / or activate a heating element associated with at least one source material segment;

[0050] Figure 18A -D shows various structural features of an actuator, according to some embodiments of the present invention, such as that described in Figure 17A -B;

[0051] Figure 19A -B shows a camshaft mechanism for selectively accessing source material segments in a sequential manner, according to some embodiments of the present invention;

[0052] Figure 20 shows a deformable access area for selectively accessing one or more source material segments, according to some embodiments of the present invention;

[0053] Figure 21A -C shows, according to some embodiments of the present invention: a mouthpiece ( Figure 21A and 21B ) and a frame ( Figure 21C ) for use with an array of source material segments;

[0054] Figure 22 is a cross-sectional view of an arrangement of a plurality of source material segments and dedicated air flow ducts, according to some embodiments of the present invention;

[0055] Figure 23 is an external view of an arrangement, according to some embodiments of the present invention, such as that shown in Figure 22 ;

[0056] Figure 24A -B is an example of a rotatable actuator for use with an arrangement, according to some embodiments of the present invention, such as that shown in Figure 22 ;

[0057] Figure 25A -C shows a device, according to some embodiments of the present invention, including an arrangement such as that shown in Figure 22 ;

[0058] Figure 26 shows an alternative arrangement of a plurality of source material segments and dedicated air flow ducts, according to some embodiments of the present invention;

[0059] Figure 27A -C shows the use of a shape-changing element to move a source material cover according to some embodiments of the present invention;

[0060] Figure 28 is an isometric view of an inhaler device according to some embodiments, which includes a linear arrangement of source material segments that can be accessed independently;

[0061] Figures 29A - B are schematic top views of an arrangement according to some embodiments, in which a fluid with varying viscosity is used to seal the source material;

[0062] Figure 30A -B schematically shows an inhaler device configured to receive a plurality of source material cartridges according to some embodiments; and

[0063] Figure 31A -B schematically shows an air flow scheme through a device including a plurality of source material segments according to some embodiments. Detailed Description

[0064] Some embodiments of the present invention relate to the delivery of at least one active substance by inhalation, and more specifically but not exclusively to the delivery of at least one active substance through a plurality of delivery events, wherein a controlled portion of the source material is heated independently of other portions of the source material.

[0065] Aspects of some embodiments relate to a device configured to heat at least one source material segment selected from a plurality of source material segments independently of unselected active substance segments. In some embodiments, the device is configured to heat the source material segments simultaneously and to allow an air flow through the source material segments in order to evaporate the active substance by heating.

[0066] In some embodiments, the source material is arranged in a plurality of segments. Optionally, the segments are thermally and / or electrically isolated from each other. Alternatively, the source material is arranged in a continuous single segment.

[0067] Optionally, only a portion of the continuous segment is heated at a given time. Optionally, a plurality of segments are heated simultaneously to deliver a combination of active substances.

[0068] In some embodiments, the source material is protected by a sealant. In some embodiments, the sealant is a structure impermeable to air and / or materials. In an example, the sealant is a foil, such as a stainless - steel foil. In some embodiments, the sealant includes a control region through which one or more openings can be formed to allow air to flow through the sealant and through the source material.

[0069] Optionally, the openings are formed during use.

[0070] In some embodiments, the control region of the sealant includes a mechanically sensitive region, and at least one opening can be formed in the sealant by applying a force. In an example, a force in the form of air pressure generated by the user's inhalation is applied to the control region. In another example, a knife or a punching machine is used to penetrate the sealant. Additionally or alternatively, the control region of the sealant includes a temperature-sensitive region, and at least one opening can be formed in the sealant by heating the sealant. Additionally or alternatively, an electric current is applied to the sealant to form at least one opening through the sealant.

[0071] Additionally or alternatively, the control region of the sealant includes a chemically sensitive region.

[0072] In some embodiments, the sealant is configured to heat a source material to evaporate at least one active substance. For example, when the sealant is resistive, the sealant can heat the source material when an electric current is applied thereto. Optionally, the sealant includes a shape memory material that is configured to deform when heated to allow air to pass through the sealant.

[0073] In some embodiments, additional components are used to perform the heating of the sealant, such as: magnetic induction of the sealant or other components; heat radiation transfer to the sealant or to other components; convection of heat from a heat source; and / or other mechanisms suitable for heating the sealant. Optionally, the sealant includes a thermosensitive material that dissolves when heated to allow an air flow through.

[0074] In some embodiments, the heating element includes an electrode and / or is connected to an electrode, and an electric current is applied through the electrode to heat a temperature-sensitive region, such as a region of the sealant. In some embodiments, the heating element includes a heatable plate, a hot air source (e.g., a generator), a heat emitter, and / or any other suitable heat source.

[0075] In some embodiments, the opening formed in the sealant allows an air flow in a single direction, thereby preventing the backflow of the active substance. In some embodiments, for example after the source material has been used, the opening in the sealant is resealed.

[0076] Alternatively, the source material is enclosed within and / or otherwise in contact with an element that is initially air-permeable, such as a mesh or a perforated foil.

[0077] In some embodiments, the device includes an air flow element that is configured to direct an air flow through a source material section. Optionally, the air flow element moves dynamically (e.g., by sliding, being dragged, rolling) across the source material. In some embodiments, the air flow element includes a set of electrodes that are used to apply an electric current to the heating element and / or to the sealant of a target source material section to heat the source material and / or to perforate the sealant.

[0078] In some embodiments, the air stream is heated before being conveyed through the source material. Optionally, in embodiments where the source material is enclosed within and / or covered by an air-impermeable sealant, the heated air stream forms at least one opening through the sealant to allow air to be conveyed through at least a portion of the source material.

[0079] In some embodiments, air that is drawn into the device in response to suction generated by a user's inhalation is directed to be conveyed through a section of the source material. In some embodiments, the air is conveyed through the thickness of the source material, e.g., entering through a first surface of the material and exiting through an optionally opposite second surface of the source material. Additionally or alternatively, the air enters and exits the source material on the same side.

[0080] In some embodiments, heating is applied to extract and / or otherwise release at least one active substance from the source material and / or to unseal the sealant, while simultaneously enabling air to be conveyed through. Then, the air entraining the active substance that exits the source material section is delivered to the user by inhalation.

[0081] In some embodiments, the heating element and / or the air stream element and / or the power application element (e.g., an electrode) are aligned relative to each other and relative to one or more selected sections of the source material. Optionally, when aligned relative to a control region of the sealant, one or more of the heating element and / or the air stream element and / or the power application element act as an actuator for opening one or more openings (e.g., holes, perforations, slits) through the sealant, which allow air to flow therethrough. In some embodiments, the alignment is temporary. In some embodiments, the alignment of two or more of the heating element and / or the air stream element and / or the power application element relative to each other is controlled by pre-setting via software. Optionally, the controller of the inhaler device is configured to control the activation and / or position of the heating element and / or the air stream element and / or the power application element in order to effect the alignment.

[0082] Optionally, the alignment is obtained before and / or during use of the selected section. Optionally, the alignment is maintained until the source material of the selected section is consumed, and / or until another source material section is loaded.

[0083] In some embodiments, the amount of source material in each segment comprises a single dose of the active substance. In an embodiment, the device comprises a single source material segment. Optionally, the amount of source material in a single segment comprises a single dose of the active substance. In some embodiments, the amount of source material in a single segment is sufficient for a plurality of delivery events, which may include multiple inhalations by the user. Optionally, the device is configured such that a lesser amount of the active substance is delivered to the user in each delivery event as compared to the amount delivered in a previous delivery event.

[0084] In some embodiments, the device comprises a loading mechanism (e.g., where an air flow element advances from a used source material segment to an unused segment). Optionally, the loading mechanism is user-controlled, allowing the user to control the device to advance to an unused source material segment as desired. Potential advantages of a user-controlled loading mechanism may include a psychological effect for the user, where the user expects to maximize the efficacy of the newly loaded dose.

[0085] Additionally or alternatively, the loading mechanism is operated automatically.

[0086] In some embodiments, the source material comprises tobacco or consists of tobacco.

[0087] Additionally or alternatively, the source material comprises other plants or consists of other plants.

[0088] In some embodiments, the source material is the sole material supply used by the device or comprises at least 90% or at least 95% by weight of the material supply used by the device. Optionally, the entrained air flow delivered by the device to the user comprises only one or more active substances extracted solely from the source material. Optionally, any active substances in the entrained air flow delivered by the device to the user are limited to flavor and / or aroma molecules.

[0089] As used herein, the term "active substance" means a thermally evaporable substance that includes a compound having at least one medicinal and / or somatic effect. Optionally, the compound includes one or more alkaloids, such as nicotine. In some embodiments, the thermally evaporable substance evaporates at a temperature that requires a substantially exogenous heat input to reach a temperature above ambient temperature. For example, the substance evaporates at a temperature in the range from 80°C - 250°C, or at a temperature in another range having the same, higher, lower, intermediate, and / or intermediate boundaries, such as between 160 - 230ºC. In some embodiments, the substance evaporates at a temperature above 80°C, 100°C, 150°C, 200°C, 230°C, or another higher, lower, or intermediate temperature. In some embodiments, the time to reach the volatilization temperature is, for example, in the range between about 100 milliseconds and 5 seconds, between 100 and 750 milliseconds, between 150 and 300 milliseconds, or in another range having the same, greater, smaller, and / or intermediate boundaries. Specifically, the time is, for example, 250 milliseconds, 500 milliseconds, 1000 milliseconds, or another greater, smaller, or intermediate value.

[0090] In some embodiments, the sealant covers all of the source material such that all of the material is protected by the sealant and no material is free.

[0091] In some embodiments, the device is substantially shaped like a conventional cigarette, e.g., including a cylindrical configuration. Alternatively, the device is shaped as a substantially flat strip and / or includes any other configuration suitable for delivering at least one active substance by inhalation.

[0092] Aspects of some embodiments relate to creating an air flow path between one or more selected source material segments and the output to the user. In some embodiments, creating the air flow path includes modifying the state of an air flow path (e.g., a conduit) associated with one or more selected source material segments from a state that does not allow air flow through to a state that allows air flow through. In some embodiments, a blocking element is removed, displaced, removed, and / or otherwise moved out of the path to allow air flow through. When the path is unblocked, air is allowed to flow to and optionally through the source material of the one or more selected segments. In some embodiments, the source material is heated concomitantly (simultaneously and / or shortly before and / or shortly after) with creating the air flow path to extract at least one active substance from the source material and deliver the active substance to the user via the air flow. In some embodiments, the heating is triggered by sensing a parameter of the air flow (e.g., pressure).

[0093] In some embodiments, the source material segments are held fixed relative to each other. In some embodiments, the source material segments are held fixed relative to one or more of the following: a heating element associated with the segment and configured to heat the source material; a conduit associated with the segment and extending between the segment and the output to the user; the housing of the source material cartridge.

[0094] Some embodiments include an actuator configured to create an air flow path. For example, in some embodiments, the actuator is configured to move a blocking element (e.g., open a cover of the source material segment), align an opening of the conduit with an air flow outlet, and / or otherwise modify the path such that air is allowed to flow to the source material. In some embodiments, the actuator is configured to activate heating of the source material, for example by closing a circuit such that a heating element associated with the selected source material segment is activated. In some embodiments, once the circuit is closed, heating is triggered or increased in response to sensing an air flow, e.g., in response to the user's inhalation.

[0095] In some embodiments, the actuator is manually operated. Additionally or alternatively, the actuator is automatically operated, e.g., controlled by a controller of the device.

[0096] In some embodiments, operations such as selecting one or more source material segments and / or activating heating of the source material and / or modifying (e.g., opening) the air flow path are mechanically actuated. Additionally or alternatively, operations such as those described are electronically controlled and / or actuated, e.g., by using solid-state switches such as transistors.

[0097] Aspects of some embodiments relate to using a fluid with a viscosity change as a sealant for the source material. In some embodiments, a fluid that changes its viscosity in response to a temperature change covers at least a portion of the source material, the fluid being, for example, silicone oil. Optionally, the fluid is disposed on a mesh or other framework containing the source material. In some embodiments, when heat is applied to the mesh, the viscosity of the fluid decreases and the fluid flows away (in the example, the fluid flows away from the mesh and is then collected in one or more side chambers), thereby exposing at least a portion of the source material to the air flow. Optionally, when the heating terminates, the fluid cools down and spontaneously returns to cover the exposed area again. In some embodiments, a change in surface tension and / or wetting properties of the fluid causes movement of the fluid, e.g., causes the fluid to flow back to its initial position. Optionally, capillary action of the fluid enables it to flow through small-diameter channels extending to and / or from the mesh.

[0098] Aspects of some embodiments relate to an apparatus configured to receive a plurality of cartridges, each cartridge including one or more source material segments, the apparatus optionally being configured to use the segments based on the contents of the segments. In some embodiments, the plurality of source material segments are selected for use according to a predetermined scheme and / or are selected for use as needed based on the contents and / or location of the segments. In some embodiments, the cartridges and / or the source material segments of different cartridges differ from each other in at least one of the following: type of source material; type of active substance; amount of source material; and amount of active substance.

[0099] According to some embodiments, the term "substrate" as used herein may include a rod, a solid structure, a surface having a thickness, and / or other elements including holes or grooves in which source material may be contained.

[0100] According to some embodiments, the term "frame" as used herein may include a structure, a housing, a cage, and / or any other element that defines a dimensionable empty space, a space or segment in which source material may be contained.

[0101] Both of the two terms "substrate" and "frame" as used herein are intended to encompass structures suitable for containing source material in one or more defined spaces.

[0102] It should be noted that at least one active substance delivered to the user is not limited to the form of vapor, and it may additionally or alternatively be provided as a spray.

[0103] Before explaining in detail at least one embodiment of the present invention, it is to be understood that the present invention is not necessarily limited in its application to the details of the construction and / or the arrangement of components and / or methods set forth in the following description and / or illustrated in the drawings and / or examples. The present invention is capable of other embodiments or of being practiced or carried out in various ways.

[0104] Now referring to the drawings, Figure 1A is a flowchart of a method of operating an evaporation device configured to deliver at least one active substance to a user by inhalation according to some embodiments.

[0105] In some embodiments, the apparatus includes or in some embodiments the apparatus is configured to receive a cartridge (120) including a plurality of discrete source material segments. In some embodiments, the apparatus includes a single source material segment.

[0106] In some embodiments, the source material is covered by a sealant, such as a sealant that contacts one or more surfaces of the source material. Optionally, the sealant is an artificially manufactured sealant, such as a resistive material optionally in the form of a foil, such as a metal foil.

[0107] In some embodiments, the sealant prevents air and / or moisture from entering the source material. Optionally, the sealant prevents evaporation and / or oxidation and / or degradation of the source material and / or the active substance. In some embodiments, the sealant is formed of a material that is suitable for heating the source material, for example, when an electric current and / or a warm air flow and / or radiation (e.g., infrared heating) and / or other heating methods are applied to the sealant.

[0108] In some embodiments, at least one source material segment is unsealed (122).

[0109] Optionally, all of the inhalable active substance in the device or at least 90% or at least 95% by weight of the inhalable substance in the device is enclosed within the sealant, and its inhalation depends on such unsealing. Optionally, at least a portion of the sealant becomes air-permeable, thereby allowing air to be delivered to and through the source material. In some embodiments, unsealing is performed by applying a mechanical force to the sealant (e.g., by opening one or more openings through the sealant). In some embodiments, the mechanical force can be applied by an air flow and / or by adjusting the position of the air flow conducting arrangement. Optionally, this is performed by the device as a necessary step for inhaling any active substance through the device. Additionally or alternatively, the sealant includes one or more temperature-sensitive control regions, optionally including thermosensitive materials and / or structures, and unsealing is performed by heating the sealant. Optionally, the temperature-sensitive control region includes a shape memory material, such as nitinol.

[0110] In some embodiments, the source material is contained within and / or otherwise in contact with an element that is initially air-permeable, such as a mesh or a perforated foil.

[0111] In some embodiments, the device is configured to simultaneously direct an air flow to and through the source material of one or more selected segments, and to heat the source material in at least one of the selected segments to release the active substance (124) by evaporation through the source material.

[0112] In some embodiments, the device is configured to deliver more than one active substance simultaneously.

[0113] In some embodiments, the device includes an air flow element configured to direct a flow through the source material segments. Optionally, air entering the device due to suction, for example, caused by inhalation by a user through the device, is conducted by the air flow element to the source material. In some embodiments, the air flow element is configured to move across the source material, such as from one segment to another.

[0114] In some embodiments, the device is configured to heat a source material. In some embodiments, heating is applied to a heating element (e.g., a mesh) and / or a sealant (e.g., a foil) that is in contact with the source material, for example by applying electricity. In some embodiments, the air flow element includes an electrode configured to conduct an electric current to the sealant and / or the heating element. Additionally or alternatively, the air flow element is configured to direct a flow and heat a section of the source material, for example by including a heating element (e.g., a mesh).

[0115] Additionally or alternatively, heating is applied to the source material by preheating an air flow that is directed to pass through the source material.

[0116] In some embodiments, the user's inhalation through the device initiates the advancement of the air flow element to a section of the source material that has not yet been used. In some embodiments, the user's inhalation through the device initiates the heating of the source material. In some embodiments, the user's inhalation through the device initiates the unsealing of the sealant of the source material.

[0117] In some embodiments, the air leaving the heated source material includes vapor of at least one active substance released from the source material, and it is delivered to the user (126) by inhalation.

[0118] In some embodiments, steps 122 - 126 (128) are repeated on one or more different sections of the source material. Optionally, the process is repeated during the user's next inhalation. In some embodiments, subsequent sections of the source material are automatically unsealed. In some embodiments, the air flow element is automatically moved to a subsequent section of the source material. Additionally or alternatively, the air flow element is manually moved to a subsequent section of the source material. In some embodiments, the sealant of a previously heated section is resealed, for example to prevent or reduce air flow through the already heated source material.

[0119] Figure 1B is a schematic view of a device configured to provide at least one active substance by inhalation according to some embodiments of the present invention.

[0120] In some embodiments, the device is intended for therapeutic use. Additionally or alternatively, the device is intended for recreational use, such as for vaporizing tobacco.

[0121] In some embodiments, device 100 includes: a housing 102; a mouthpiece 104; a cartridge containing one or more source materials, such as 106 and / or 107; a power source 108 configured to apply electricity 109 to the cartridge to vaporize an active substance by heating the source material; and / or an air conduction arrangement 110 to direct an air flow through a section of the heated source material and through the mouthpiece for inhalation by the user. Optionally, the device includes a controller 112.

[0122] In some embodiments, a cartridge such as 107 includes discrete, separate segments of source material 114. Alternatively, a cartridge such as 106 includes a single continuous source material spanning one or more segments of source material. In some embodiments, the source material is configured within or otherwise in contact with an element 111 that is configured to heat the source material (e.g., when an electric current is applied thereto) and / or provide structural support to the source material, such as being shaped as a frame that contains the source material. In some embodiments, the frame merely houses the source material. Optionally, the source material is housed within separate segments, such as segments defined by walls. Optionally, the separation between segments is configured to thermally isolate and / or electrically isolate the source material segments from each other. Optionally, the separation between segments prevents these segments from being in the same path of an air flow. Alternatively, the source material is formed as a single solid block contained within the frame.

[0123] In some embodiments, element 111 includes a mesh or foil. Optionally, the foil is air permeable. Alternatively, the foil is air impermeable and is configured to become air permeable during use, such as described below.

[0124] In some embodiments, a discrete cartridge such as 107 includes electrical and / or thermal isolation portions 116 configured between segments of source material. In some embodiments, isolation portion 116 comprises or consists of one or more of the following materials: liquid crystal polymer (LCP), Ultem (polyetherimide), Teflon (polytetrafluoroethylene), Torlon (polyamideimide), Amodel (polyphthalamide), Ryton (polyphenylene sulfide), Forton, Xydear, Radel (polyphenylsulfone), Udel (polysulfone), polypropylene, Propylux, polysulfone, polyethersulfone, acrylic, ABS, nylon, PLA, polybenzimidazole, polycarbonate, polyetherimide, polyethylene, polyphenylene ether, polyphenylene sulfide, polystyrene, polyvinyl chloride, another thermoplastic, polyimide (PI), polyaryletherketone (PAEK), such as polyetheretherketone (PEEK), polyetherketone (PEK), or polyetherketoneetherketoneketone (PEKEKK), or a fluoropolymer, such as polytetrafluoroethylene (PTFE), polyvinylidene fluoride (PVDF), ethylene tetrafluoroethylene (ETFE), PVDFELS, or fluorinated ethylene propylene (FEP), and / or another polymeric material. In some embodiments, portion 116 includes a conductive material (e.g., aluminum). Optionally, portion 116 includes an electrically insulating layer, such as an anodized coating.

[0125] The potential advantage of LCP and / or PEEK lies in their good tolerance to temperatures higher than the temperature required to evaporate the source material contained in the cartridge (e.g., an evaporation temperature of 230 °C).

[0126] In some embodiments, heating is applied only to a selected source material section (in cartridge 106 or 107), e.g., by applying electrical power. In some embodiments, air is directed to flow only through or mainly through the selected source material section.

[0127] In some embodiments, each source material section is heated independently of the other sections, e.g., by applying current to different resistive heating elements in contact with the source material of that section. In some embodiments, heating is performed when air is directed to flow through the source material section to be conveyed to the user via the air conduction arrangement 110.

[0128] In some embodiments, control of the heated section is provided by controlling the air flow through the device and / or controlling the heating. In some embodiments, the air flow is controlled to pass through certain source material sections or portions thereof. Additionally or alternatively, heating is controlled to evaporate certain source material sections or portions thereof, e.g., by heating only a portion of heating element 111. In some embodiments, heating of source material sections other than the target section is avoided. Optionally, the non-target sections include: sections that have been heated; and / or sections that have not been heated and are different from the target section.

[0129] In some embodiments, the air conduction arrangement 110 is configured to allow air flow within a limited volume of the device. In some embodiments, the air flow is optionally directed via one or more conduits to pass through certain target source material sections. Additionally or alternatively, a certain degree of resistance, obstruction, and / or flow resistance is imposed on the inhalation flow drawn by the user through the device to limit the flow.

[0130] In some embodiments, the device includes a controller 112. In some embodiments, the controller 112 is used to control the amount of active substance delivered by the device, e.g., by adjusting one or more of the following: heating parameters (e.g., temperature, duration); flow parameters; the amount of source material heated; and / or other parameters.

[0131] In some embodiments, the source material includes plant material, such as tobacco and / or other vegetable materials. In some embodiments, the released active substance includes a complex having at least one medicinal and / or somatic effect. Optionally, the complex includes nicotine. In some embodiments, the source material is a volatile substance distributed throughout a tray including a carrier material. Optionally, the carrier material includes at least one vegetable substance, such as tobacco and / or other plant substances. Additionally or alternatively, the carrier material includes: a porous and air-permeable absorbent matrix; for example, foam, sponge, felt, and / or another fibrous matrix that absorbs the active substance to hold it in place. In some embodiments, the absorbent matrix is substantially non-friable, thereby providing sufficient strength, for example, to allow other cartridge components, such as a heating element, to be directly attached to or attached within the absorbent matrix without additional mechanical supports to maintain the integrity of the absorbent matrix surface and / or structure. In some embodiments, the tray is friable; for example, it includes particles, fibers, or another fine structure that is compressed to form the tray.

[0132] In some embodiments, the source material includes one or more isolating materials, essential oils, extraction materials, and / or synthetic complexes.

[0133] In some embodiments, the source material includes different plants, different varieties, different blends, different additives, and / or different concentrations of one or more substances.

[0134] In some embodiments, the source material evaporates at a temperature that requires a substantially exogenous heat input to reach a temperature above ambient temperature. For example, the substance evaporates at a temperature in the range from 80°C - 250°C, or at a temperature in another range having the same, higher, lower, intermediate, and / or intermediate boundaries, for example, between 160 - 230ºC. In some embodiments, the substance evaporates at a temperature above 80°C, 100°C, 150°C, 200°C, 230°C, or another higher, lower, or intermediate temperature. In some embodiments, the time to reach the evaporation temperature is, for example, in the range of approximately 100 milliseconds to 5 seconds, between 100 and 750 milliseconds, between 150 and 300 milliseconds, or in another range having the same, greater, smaller, and / or intermediate boundaries. Specifically, the time is, for example, 250 milliseconds, 500 milliseconds, 1000 milliseconds, or another greater, smaller, or intermediate value. In an example, nicotine is extracted at a boiling point of approximately 247 degrees Celsius in a period of approximately 3 seconds or less. In some embodiments, element 111 is resistive. Optionally, element 111 includes or is composed of a metal, such as nichrome, FeCrAl, cupronickel, titanium, and / or stainless steel.

[0135] In some embodiments, element 111 is packaged in thermal contact with the source material to heat the source material. Thermal contact includes, for example, direct contact or contact across a heat transfer layer that permits a high rate of heat transfer (e.g., includes a high thermal conductivity material such as red copper, aluminum, brass, or stainless steel; and / or has a thin wall structure with a thickness less than about 10 µm, 20 µm, 25 µm, 50 µm, or another larger, smaller, or intermediate thickness). In some embodiments, thermal contact includes juxtaposing the tray and element 111 sufficiently closely such that the tray substantially faces the entire thermal radiation angle of the portion of the element that covers the tray; e.g., greater than 90%, 95%, 99%, or another larger, smaller, or intermediate value. In some embodiments, the peak current applied to the electrodes is in the range of about 1–10 amperes, e.g., is about 1 ampere, 2 amperes, 4 amperes, 6 amperes, or another higher, lower, or intermediate current.

[0136] In some embodiments, thermal contact includes element 111 extending across and contacting one or more surfaces of the tray, such as one side of the tray, or two opposite sides of the largest surface area. In some embodiments, thermal contact includes element 111 being at least partially embedded within the tray.

[0137] In some embodiments, element 111 is permeable to the conveyance of air. In some embodiments, the tray is permeable to the conveyance of air. Permeability occurs, for example, under conditions where air at ambient temperature is conveyed through element 111 and the heated assembly of the tray under a suction pressure and / or a positive pressure, where the suction pressure is, for example, a suction pressure generated by inhalation, and the positive pressure is generated from the side that is away from the inhalation side of the cartridge. In some embodiments, the applied pressure is in the range of 5–20 mmHg, 10–25 mmHg, 5–30 mmHg, 25–40 mmHg, 30–50 mmHg, or in another range having the same, higher, lower, and / or intermediate boundaries. According to some embodiments, the tray has an air-permeable structure that permits a flow of at least 0.5 liters of gas per minute, or even at least 0.75 liters of gas per minute, or 1 liter of gas per minute under a pulling vacuum of at least 1–5 kPa (-1-(-5)kPa). In some embodiments, the tray has this permeability in its packaged form. In some embodiments, this permeability is achieved during heating of the tray, e.g., due to volatilization, drying, melting, and / or combustion of the tray components.

[0138] In some embodiments, power supply 108 is configured to supply sufficient power to heat a selected number of source material segments 114. Optionally, power supply 108 is configured to supply sufficient power to heat all of the source material contained within the device. In some embodiments, the power supply is a battery. Optionally, the battery is rechargeable. Optionally, the battery is chargeable from outside the device.

[0139] Figures 2A - C illustrate three configurations of the connection between the source material and the resistive heating element according to some embodiments of the present invention.

[0140] In some embodiments, the source material 200 is connected to a resistive heating element 202, such as a mesh or foil.

[0141] In some embodiments, the connection between the source material and the heating element is configured to provide uniform heating of the source material.

[0142] Optionally, the source material is formed before or during insertion such that it follows the optionally flat shape of the heating element. Accommodating the source material in a flat form is potentially advantageous because the larger surface area and / or more uniform thickness potentially allow for faster and / or even more uniformly distributed heating and / or air flow during dose evaporation and delivery. In some embodiments, the thickness of the source material, as measured in the direction in which air flows through the source material, is in the range between 0.5 - 5 mm, or between 0.5 - 2 mm, or between 0.5 - 1.5 mm, for example 1 mm, 2.5 mm, 4 mm or intermediate, higher or lower thicknesses.

[0143] In the example shown in Figure 2A, the source material is sandwiched between two heating elements. The potential advantage of enclosing both sides of the source material used in some embodiments is that the rate and / or uniformity of evaporation increases when current is applied to the heating element.

[0144] In the example shown in Figure 2B, the bottom surface of the source material contacts the heating element. Alternatively, the top surface of the source material may form contact with the heating element.

[0145] In Figure 2C the example shown, the heating element is embedded within the source material.

[0146] In some embodiments, the source material 200 and / or the heating element 202 are arranged to provide an air flow 204 to flow through. Optionally, the heating element 202 is a mesh and / or other air - permeable structure. Optionally, the source material 200 consists of or is contained within a porous matrix, and / or is otherwise arranged to allow air flow through.

[0147] Alternatively, the heating element is air-impermeable. Optionally, the heating element is configured to become permeable during use.

[0148] In some embodiments, the heating element includes an infrared heater.

[0149] Figure 3 A configuration according to some embodiments of the present invention is shown, in which the heating element 300 is movable relative to the source material 302.

[0150] In some embodiments, optionally during use, the heating element 300 moves to a position where it contacts the source material or a portion of the source material. Optionally, the heating element is configured to advance over the source material to heat different portions of the source material. Optionally, the heating element is sized to contact a portion of the source material that includes a certain amount of active substance, which provides a single predetermined dose when vaporized. In some embodiments, the source material includes a support structure (not shown). Optionally, the support structure is air-permeable. Optionally, the support structure is heat-resistant. In some embodiments, the movable heating element is configured to be attached to the support structure. In some embodiments, the movable heating element is configured as part of and / or includes an air flow element, for example, as further described herein, the air flow element guides an air flow 304 through the heated active substance section.

[0151] Figure 4A -C shows a method and / or structure for dynamically changing the air permeability of the sealant of the heating element and / or the source material according to some embodiments of the present invention. In some embodiments, the sealant is configured to heat the source material and thus serves as a heating element.

[0152] In some embodiments, the heating element or at least a portion of the heating element is initially air-permeable. Alternatively, the heating element is sealed and unsealed during use to allow air to be transmitted through the source material. Figure 4A -C shows various methods and structures for dynamically changing the air permeability of the sealant of the heating element and / or the source material.

[0153] In some embodiments, for example, as Figure 4A shown, the heating element is a foil 400 that includes one or more force-sensitive control regions 402. When a force (e.g., pressure, stretch, twist, and / or bending force) is applied to the foil, its force-sensitive regions or portions deform to allow air flow to pass through. Optionally, the flow is an air flow caused by the user inhaling through the device.

[0154] Optionally, the force-sensitive control regions are etched into the foil.

[0155] Additionally or alternatively, the foil is perforated. Additionally or alternatively, the foil is folded onto itself to form a scaly arrangement.

[0156] In some embodiments, the heating element includes a temperature-sensitive control region. Optionally, the temperature-sensitive region includes a shape memory material. Optionally, during heating, its region or part deforms to allow air flow through. In some embodiments, when the heating element cools down, the temperature-sensitive region returns to a closed state. Potential advantages of using the temperature-sensitive region may include an inherent air flow arrangement, such that the air flow can only pass through the heated part and ensure that the flow through the non-heated part is blocked. Optionally, the direction of deformation will cause a greater surface contact between the heating element and the substance.

[0157] In Figure 4A the example of, the foil 400 includes 316L stainless steel foil, or optionally a shape memory conductive material, such as nitinol and / or Cu-Al-Ni alloy and / or Fe-Mn-Si-Cr-Ni alloy and / or Cu50Zr50. In some embodiments, the scaly pattern is etched onto the foil. Optionally, when a force is applied and / or when the foil is heated, the foil deforms (e.g., expands or twists) and at least some of the regions change shape to allow air to be conveyed through, such as through the opening 404. In some embodiments, applying a force in the opposite direction and / or cooling the foil causes the regions to deform back to their initial configuration, and the openings through which air is conveyed close.

[0158] In some embodiments, for example as Figure 4B shown, the sealant 414 is configured to operate as a one-way valve. Optionally, when suction and / or air pressure is applied (e.g., during inhalation by the user through the device), one or more valves 406 constructed in the sealant 414 move to allow air to be conveyed through the source material 408. Optionally, the valve is formed as an integral section of the sealant. In some embodiments, when suction stops (e.g., when inhalation stops), the valve moves to a closed position. In the configuration as described, it may be advantageous to use a sealant in the form of a foil (e.g., stainless steel foil) or a flexible sealant (e.g., made of silicone).

[0159] In some embodiments, the heating element 416 is configured to be between the sealant 414 and the source material 408.

[0160] In some embodiments, as also in Figure 4BAs shown in the example of, the air flow element 410 is used. Optionally, the air flow element can move (e.g., by sliding) on the sealant 414 and / or on the heating element 416 and / or directly on the source material and / or via a support structure. In some embodiments, the air flow element is positioned on a portion of the sealant such that valves constructed only within that portion open, for example, when suction and / or air pressure is induced via the air flow element to allow air transfer therethrough.

[0161] In some embodiments, such as as Figure 4C shown in, the heating element 418 includes a shape memory material, such as nitinol. Optionally during heating, one or more vanes 412 formed in the foil deform (e.g., are lifted away from the source material) to allow air flow through. In some embodiments, when power is stopped and the heating element cools down, the vanes deform back to their closed configuration. Additionally or alternatively, mechanical force is applied to reseal the vanes, for example, using a hammer or a roller.

[0162] Additionally or alternatively, the heating element is air permeable and coated with a sealant layer that is unsealed during use to expose the heating element.

[0163] Additionally or alternatively, a mechanical element configured to perforate the heating element is used, such as in the form of a rotary cutter or a punching machine.

[0164] Optionally, in embodiments where the heating element is air permeable and includes a seal or coating as described above, a mechanical element shaped and / or sized to tear and / or perforate and / or remove a portion of the seal is used.

[0165] Additionally or alternatively, the seal or coating of the heating element is manually removed by the user and / or mechanically removed, for example, when the cartridge is inserted into the device.

[0166] In some embodiments, the sealant of the source material comprises a silicone film. Optionally, the source material is enclosed within a mesh or foil, and the silicone film is a coating on the mesh of the foil. Optionally, the thickness of the silicone film is between 100 - 500 microns, such as 200 microns, 300 microns, 400 microns. In some embodiments, the silicone film includes slits that open in response to pressure to allow air to pass through, such as the air pressure applied when an air stream is directed to a section of the source material (e.g., the air pressure induced by inhalation). Additionally or alternatively, the sealant includes a thin layer of a perfluoroalkoxy (PFA) film having a thickness, for example, between 10 - 50 microns, such as 15 microns, 25 microns, 40 microns. Optionally, the film includes slits as described above. Optionally, the material is sufficiently elastic such that the slits close back to the sealed position when the pressure, such as air pressure, ceases.

[0167] In some embodiments, the sealant encloses a material that is configured to occupy a larger volume when heat is applied thereto, such as an inert non-toxic gas with a low boiling point (e.g., helium), a solid and / or a liquid configured to sublime. Optionally, the application of heat will cause the material to expand and cause the sealant to rupture.

[0168] Figure 5A -B shows two flow patterns according to some embodiments of the present invention, in which an air stream is directed through the source material for delivering air entraining an active substance to a user.

[0169] In some embodiments, the device 514 includes an air flow element 500 that includes one or more conduits and / or valves or other structures suitable for directing an air stream through the source material or a selected portion of the source material. In some embodiments, the air flow element 500 defines a conduit 502 through which suction is induced during inhalation, thereby directing the air stream entering the device through at least a portion 504 of the source material 506.

[0170] In some embodiments, the air flow element 500 includes one or more electrical contacts (not shown) for conducting an electric current to at least a portion of the heating element 508 that contacts the source material. In some embodiments, the electrical contacts are shaped to conduct the electric current to a limited area of the heating element that at least partially corresponds to the portion 504. Optionally, the electrical contacts are configured at the edge of the air flow element, thereby spanning the source material on opposite sides.

[0171] In some embodiments, the air flow element 500 is configured to move across the source material, such as by sliding, rolling, being dragged across the source material, and / or otherwise moving along the source material. In some embodiments, the movement of the air flow element 500 is manual, such as by using a manual slider. Optionally, the slider can be moved by a user using one hand while also holding the inhaler device, which is achieved, for example, by thumb actuation. Additionally or alternatively, the movement of the air flow element 500 is automated. In embodiments where the device includes a controller, the controller can be configured to activate, modify, and / or stop the movement of the air flow element.

[0172] In some embodiments, the air flow element is moved between successive delivery events (i.e., events in which the active substance vapor is delivered to the user by inhalation), heating different portions of the source material in each event.

[0173] Optionally, the delivery event includes a single inhalation. Alternatively, the delivery event includes multiple inhalations. In some embodiments, the air flow element only moves to a different portion of the source material after a plurality of delivery events. Optionally, the number of delivery events is predetermined.

[0174] Additionally or alternatively, the air flow element is configured to move to a different portion of the source material when a predetermined amount of the currently heated portion or, conversely, all of the source material has been consumed.

[0175] In some embodiments, the air flow element is shaped to direct the flow through more than one source material segment. Optionally, the plurality of source material segments are heated when the air flow element moves to a position suitable for providing an air flow to the plurality of source material segments and applying power. Optionally, the plurality of segments are heated simultaneously. Alternatively, the plurality of active substance segments are heated one after another. Optionally, the heating element is positioned at one location for multiple inhalations, with each inhalation being associated with heating a different portion or segment of the source material located within portion 504.

[0176] In Figure 5A a cross-sectional view, the air flow in conduit 502 entering the air flow element 500 is directed to pass through the source material portion 504 and continue flowing as air entraining the active substance towards the mouthpiece 510 to be delivered to the user.

[0177] In Figure 5B a cross-sectional view, the flow entering the device through opening 512 is forced to pass through the source material 506. In this example, the air flow element 500 is positioned above the source material. Optionally, the air entraining the active substance is delivered to the user via conduit 508 extending to the mouthpiece 510.

[0178] Figure 6A-C shows a mechanism for moving an air flow element along a source material according to some embodiments.

[0179] Figure 6A The movement of the air flow element along the source material 600 is schematically shown, for example, including movement achieved by rolling, sliding, being dragged along the source material, and / or other means. Optionally, the air flow element is positioned above the source material. Additionally or alternatively, the air flow element is positioned below the source material.

[0180] In Figure 6B according to some embodiments, the air flow element 602 includes a roller 604 configured to roll on the surface of the source material 600.

[0181] Optionally, the roller 604 is coupled to a rod 606 configured to pull and / or push the roller across the source material 600. In some embodiments, the roller 604 includes a mesh and / or foil and / or other perforated surface configured to heat when an electric current is applied to heat the source material in contact with the roller.

[0182] Optionally, the roller is partially surrounded by a sealed area that guides the air flow in a desired direction.

[0183] In some embodiments, the surface of the roller is studded. Optionally, according to some embodiments, the studded surface is not perforated but is configured to perforate holes in the sealant covering the source material.

[0184] In Figure 6C according to some embodiments, the cassette 620 includes a source material 600 that is contained within and / or sandwiched between layers of an air-permeable heating element 618. Optionally, the air flow element 610 includes two opposing surfaces 612 positioned such that the source material 600 is sandwiched between them. Ducts 614 extend from these surfaces to an orifice 616 to allow air to be conveyed through.

[0185] Note that an example of the source material is shown herein as a flat strip, but other configurations are also contemplated, such as a tubular arrangement (e.g., having a circular or polygonal cross-sectional profile) and / or any other shape.

[0186] Figure 7 A dynamic air flow element according to some embodiments of the present invention is schematically shown, which is configured to direct air through a selected section of the source material. In this example, the source materials are stacked in layers 702, with each layer contained within a frame 700 and defining a section of the source material. In the example shown herein, each layer includes a flat (optionally, square-shaped) block of the source material. Note that other layer configurations and / or source material layout configurations are also contemplated.

[0187] In some embodiments, a resistive element 712, such as a foil or mesh configured as a heating source, contacts the source material, for example, covering at least one surface of the source material and / or spanning the source material from both sides of an opening in the frame.

[0188] In some embodiments, the air flow element 706 includes a movable blocking member 704 configured to direct air to flow only through certain segments of the source material. In the example shown herein, the air flow 708 passes through the conduit of the air flow element 706, is directed by the blocking member 704 into the intermediate segment 710, passes through the source material 700, and then flows back into the conduit of the air flow element 706 to be delivered to the user.

[0189] Figure 8A -B shows the operation of a device including a plurality of air flow elements according to some embodiments of the present invention.

[0190] In some embodiments, a plurality of air flow elements are positioned to direct flow to a plurality of corresponding segments of the source material associated with the air flow elements and / or apply current to the plurality of corresponding segments of the source material. In some embodiments, the air flow is selectively directed through one or more of the air flow elements and not through other air flow elements. In Figure 8A , the air flow is directed to pass through the first air flow element 800, pass through the first portion 802 of the source material, and continue flowing towards the mouthpiece 808 to be delivered to the user. In Figure 8B , the air flow is directed to pass through the second air flow element 804, pass through the second portion 806 of the source material, and continue flowing towards the mouthpiece 808, pass through the first portion of the source material 802, and continue flowing towards the mouthpiece 808 to be delivered to the user. Optionally, after the first active material segment 802 is used, the first air flow element 800 is blocked to eliminate the flow through the first active material segment 802. In some embodiments, the portion of the source material that allows air to pass through (e.g., portion 802) includes a single dose of the active substance. Alternatively, portion 802 includes a plurality of dose segments, and each dose segment can be heated separately, for example, for each delivery event. Optionally, this portion is delivered to the user in a single delivery event (e.g., a single activation of the device, optionally including one or more successive inhalations by the user through the device).

[0191] Figure 9Schematically illustrated is a heating element 900 according to some embodiments, which is configured to allow an air flow through a currently heated section 902 of the source material and block the air flow through currently unused sections. In some embodiments, the heating element 900, such as in the form of a foil containing the source material, includes one or more portions 904 that are configured to become air permeable during use to allow air flow through the heated section of the source material. Optionally, when heating stops, the permeable foil portions are resealed.

[0192] Optionally, during the next conveyance event and / or the next inhalation, for example, different foil portions become air permeable, thereby allowing flow through different source material portions.

[0193] In some embodiments, a foil portion such as portion 904 is coupled to an electrode set, and current is applied to the foil through the electrode set. Optionally, multiple foil portions are coupled to multiple corresponding electrode sets. Optionally, the electrode sets are individually activated to target different source material sections. In some embodiments, for example, in the device shown in this figure, the device includes a controller, and the controller is configured to control the individual heating of different sections of the source material.

[0194] Figure 10A -F shows a cigarette-shaped device according to some embodiments of the present invention, which includes a cylindrical configuration.

[0195] Figure 10A An isometric view of the device 1000 is shown. Figure 10B A cross-sectional view of the device 1000 is shown. Figure 10C and Figure 10D Different partial exploded views of the device 1000 are shown.

[0196] In some embodiments, as Figure 10B shown, the source material 1002 includes an annular cross-sectional profile. In some embodiments, the source material is enclosed between an inner foil layer and an outer foil layer 1004, and the foil layers are configured to heat the source material, for example, by applying electricity to the foil. In some embodiments, electricity is applied via a pair of electrodes 1006, and the pair of electrodes is configured to contact the foil 1004. In some embodiments, the outer foil is surrounded by a housing 1010.

[0197] Optionally, the housing 1010 comprises a durable inert material. In some embodiments, the durable inert material comprises or consists of one or more of the following materials: liquid crystal polymer (LCP), polyetheretherketone (PEEK), Ultem (polyetherimide), Teflon (polytetrafluoroethylene), Torlon (polyamideimide), Amodel (polyphthalamide), Ryton (polyphenylene sulfide), Forton, Xydear, Radel (polyphenylsulfone), Udel (polysulfone), polypropylene, Propylux, polysulfone, polyethersulfone, acrylic, ABS, nylon, PLA, polybenzimidazole, polycarbonate, polyetherimide, polyethylene, polyphenylene ether, polyphenylene sulfide, polystyrene, polyvinyl chloride, other thermoplastics, and / or another polymeric material.

[0198] In some embodiments, a cylindrical chamber 1008 is present between the outer foil 1004 and the housing 1010 through which air can flow. In some embodiments, a sleeve 1012 extends between the proximal end 1014 and the distal end 1016 (see Figure 10A ) of the device. Optionally, the sleeve serves as a conduit for air entraining the active substance to flow in the proximal direction for delivery to the user.

[0199] In some embodiments, the distal end 1016 includes a sealed portion 1018 and an open portion 1020 configured radially outwardly relative to the seal (shown more clearly in Figure 10D ) that allows an air stream 1021 to enter the device around the seal, flow into the chamber 1008 and flow circumferentially around the outer foil 1004.

[0200] In some embodiments, the air stream flows in a radially inward direction from the chamber 1008 through the outer foil, through the currently heated section of the source material, through the inner foil, and into the sleeve 1012, and the air stream continues from the sleeve towards an orifice 1022 located at the proximal end 1014 of the device. The air stream entering the orifice 1022 includes at least one active substance, for example in the form of a vapor extracted from the heated section of the source material. In some embodiments, the orifice 1022 is configured to prevent air flow at the periphery (e.g., air flow within the chamber 1008) from entering the user's mouth. Optionally, only axial flow is allowed to pass through. In some embodiments, reverse air flow (i.e., air flowing from the user to the source material or in a similar direction) is prevented, which is achieved for example by using one or more check valves and / or other elements suitable for preventing reverse air flow.

[0201] In some embodiments, the electrode 1006 is configured to advance along the cartridge to heat different sections of the source material. Additionally or alternatively, a plurality of electrodes are arranged along the length of the cartridge and are then activated to conduct current to heat the respective foil sections.

[0202] Figure 10E and 10F An electronic cigarette including a first portion 1030 and a second portion 1032 is shown. Optionally, the first and second portions are axially coupled to each other to produce an elongated cylindrical configuration, such as seen in Figure 10F as shown.

[0203] In some embodiments, the first portion 1030 houses the battery 1034 and / or the controller 1036. Optionally, a light indicating device 1038 (e.g., an LED) is configured on the exterior of the first portion for indicating the power level of the battery and / or other operational indications.

[0204] In some embodiments, the second portion 1032 includes a cartridge 1040 of the source material. In some embodiments, the second portion 1032 includes a mouthpiece 1042 configured at the proximal end of the portion. In some embodiments, the second portion 1032 includes a device 1000 such as shown in Figure 10A - 10D as illustrated.

[0205] In some embodiments, the portions 1030 and 1032 are mechanically and / or electrically coupled to each other, such as via a connector 1044 that extends proximally from the first portion 1030 to be received within the portion 1032. Optionally, the connector 1044 consists of or includes an electrical connector for applying power to the cartridge 1040 to heat the source material contained within the cartridge.

[0206] Additionally or alternatively, other connectors may be used to connect the portions.

[0207] In some embodiments, an air flow 1046 enters the portion 1032 through a circumferential opening at the distal end of the portion 1032, such as shown in Figure 10F and Figure 10A as illustrated. In some embodiments, the source material contained within the cartridge is protected by a sealant configured to be unsealed during use, as described above, to allow the air flow 1046 to pass through. In some embodiments, the portion 1032 is disposable and the portion 1030 is configured for at least multiple uses. Optionally, the battery 1034 is rechargeable.

[0208] In some embodiments, portion 1032 includes a chip (not shown herein), which is encoded with a delivery arrangement and / or a dosing regimen and / or personal user data. Optionally, the couplings between these portions are configured to transfer data (e.g., via a USB connection), such that the controller 1036 controls delivery in accordance with the data encoded in portion 1032.

[0209] Figure 11A -C shows various disposable and / or replaceable components of a device according to some embodiments of the present invention.

[0210] In some embodiments, the entire device is configured for single use.

[0211] Alternatively, one or more components are disposable, such components being, for example, cartridge 1100 ( Figure 11A shown therein) and / or battery 1102 ( Figure 11A shown therein) and / or air flow element 1104 ( Figure 11B shown therein) and / or conduit 1106 ( Figure 11B and 11C shown therein) and / or mouthpiece component 1108 ( Figure 11B and 11C shown therein), through which air is conveyed. The mouthpiece component can be a mouthpiece configured to allow air flow from the device to the user and / or a liner for a mouthpiece included in the device.

[0212] In an example, as Figure 11C shown, cartridge 1100, conduit 1106, and mouthpiece component 1108 form a single replaceable unit.

[0213] In some embodiments, one or more of the above components are provided and optionally replaced between delivery events. Additionally or alternatively, one or more of the above components are provided and optionally replaced between different users. Additionally or alternatively, one or more of the above components are provided and optionally replaced after a predetermined period of time. Additionally or alternatively, one or more of the above components are provided and optionally replaced once all of the source material has been consumed.

[0214] Potential advantages of using disposable components for some or all of the components through which an air stream carrying an active substance is conveyed can include preventing, for example, excessive accumulation of residual condensed active substances resulting from the use of multiple cartridges, which in turn can reduce the risk of malodor during use.

[0215] Figure 12A -E is various views of a generally flat rectangular evaporation device according to some embodiments of the present invention.

[0216] Note that the flat rectangular device is merely a construction provided as an example, and the device may include other forms, optionally non-flat forms, such as a tubular construction, a disc-shaped construction, a triangular construction, and the like.

[0217] Figure 12A is an isometric view of the device 1200. In Figure 12B it, the outer housing 1202 of the device (shown in Figure 12A is not shown in order to expose the underlying structure. In Figure 12C it, the top layer 1206 of the device is not shown in order to expose the cartridge 1204. Figure 12D is a bottom view of the device. Figure 12E An example of a loading mechanism of the device according to some embodiments is shown.

[0218] In some embodiments, Figure 12B the top layer 1206 shown in includes longitudinal slits 1208, which optionally extend between the proximal end 1210 and the distal end 1212 of the device. In some embodiments, the layer 12026 is made of a flexible material, such as, for example, silicone and / or rubber.

[0219] In some embodiments, elements are provided that are configured to direct an air flow to the cartridge and / or apply electricity to the cartridge. In some embodiments, for example as shown herein, the element is configured as a movable cart 1214 that is configured to be at least partially disposed within the slit 1208. Optionally, the movable cart includes a nozzle 1216 that extends through the slit to the housing 1204 (shown in Figure 12C for directing an air flow to a corresponding portion of the cartridge. In some embodiments, the nozzle 1216 fits snugly within the layer 1206 such that the material of the layer 1206 seals the area near the nozzle, thereby ensuring that most (e.g., 80%, 90%, 95% of the flow) or all of the flow is transmitted through the nozzle.

[0220] In some embodiments, for example as shown in Figure 12C the pusher block 1214 includes electrodes 1224 and 1226 that are configured to apply an electric current to the cartridge.

[0221] Optionally, the electrodes are configured along the side edges of the pusher block 1214.

[0222] In some embodiments, for example as shown in Figure 12E the pusher block 1214 is manually moved, for example, by sliding the outer cover of the device. Additionally or alternatively, the pusher block 1214 moves automatically along the cartridge.

[0223] In some embodiments, such as those shown herein, the cartridge 1204 includes source material 1218 (e.g., tobacco) in contact with a lid that serves as a heating element and / or sealant for the source material. In this example, the source material is held within a perforated foil 1220. In some embodiments, such as those shown herein, the cartridge 1204 is shaped as an elongate strip.

[0224] Alternatively, the cartridge 1204 may include other configurations, such as a cylindrical configuration.

[0225] In some embodiments, the cartridge 1204 includes an insulating element, which is in the form of, for example, a longitudinally extending bracket 1222, as shown in Figure 12C shown herein.

[0226] Optionally, the insulating element is configured to separate electrodes 1224 and 1226 such that current can be applied to a cartridge section that is currently positioned in contact with the pusher.

[0227] In some embodiments, the cartridge 1204 includes a ratchet mechanism 1228 for advancing the pusher in a single direction (e.g., from a distal to a proximal direction).

[0228] In some embodiments, in use, air 1232 flows through the distal end 1212 into the device (e.g., upon inhalation by the user triggering suction), as shown in Figure 12D shown herein. The air flow is directed through the nozzle 1216 and to and through the source material enclosed within a cartridge section heated by the pusher. The air 1234 entraining the active substance exiting the cartridge flows along the bottom side of the cartridge and thus advances to the mouthpiece sheath 1230 to be delivered to the user.

[0229] In some embodiments, the wall opposite the bottom wall of the cartridge (not shown herein. Optionally, it is the inner surface of the housing) includes a covering or seal, such as including a non-perforated foil, for preventing the air entraining the active substance from escaping.

[0230] In some embodiments, the mouthpiece sheath 1230 includes a foil. In some embodiments, the mouthpiece sheath includes a heat-resistant and / or electrically insulating liner.

[0231] In some embodiments, the mouthpiece component 1230 (in this example, in the form of a sheath) and / or the cartridge 1204 and / or the battery and / or the flow conduit (e.g., between the bottom of the cartridge and the inner wall of the housing) are disposable and replaceable.

[0232] In some embodiments, the device may be configured to provide a smoke effect during use, for example, by allowing vapor to escape from the device. Optionally, the vapor is derived from a heated source material and / or from added substances such as propylene glycol (PG) and / or vegetable glycerin (VG).

[0233] In some embodiments, to provide an electronic cigarette equivalent to a conventional cigarette, the following may be used:

[0234] For each delivery event, approximately 20 mg of tobacco may be heated. Optionally, the source material may be sufficient in total for 10 to 15 delivery events, each delivery event including, for example, a single inhalation. Optionally, the source material is formed into a 0.5 mm thick strip and / or other structures. Optionally, the source material is covered by a perforated foil that contacts the top and bottom surfaces of the strip.

[0235] In some embodiments, a power source in the form of a battery or a hybrid of a supercapacitor and a battery is used to apply power to each 20 mg segment of the source material. Optionally, the power source is configured to supply sufficient energy for a single electronic cigarette. Alternatively, the power source is configured to supply sufficient energy for multiple electronic cigarettes. In an example, for each milligram of tobacco heated, the battery is configured to provide at least 4 watts, at least 3 watts, at least 6 watts, or intermediate, higher, or lower power. Optionally, the battery is rechargeable. Optionally, the battery is disposable. Examples of commercially available batteries suitable for use in a device such as described herein may include:

[0236] LiPo - lithium polymer; a battery pack having two batteries in a row may be used. A suitable battery is, for example, the SLPB503435H4 manufactured by KoKam;

[0237] The nano-phosphate high-power LiOn battery ANR26650 manufactured by A123; and

[0238] A hybrid of a supercapacitor and a lithium-ion battery. The supercapacitor provides energy to the cartridge in a burst mode, while the battery charges the capacitor between multiple uses. An example of a suitable supercapacitor is the BCAP10350 from Maxwell Corporation.

[0239] In some embodiments, a single dose consists of ground plant material weighing between 10 mg and 50 mg. Optionally, the dose is flattened to be between 0.5 and 1.5 mm perpendicular to the width of the heating element. Some non-limiting examples include 20 - 40 mg of tobacco and a mixture of 15 mg of tobacco and 25 mg of cinnamon, each of which may evaporate, for example, at 265 ºC.

[0240] In some embodiments, the amount of active substance delivered from the source material of a single segment to the user is equivalent to the amount of active substance inhaled in a single puff when smoking a conventional cigarette, which includes, for example, between 50 and 150 milligrams of nicotine. Optionally, this amount varies according to the concentration of the active substance in the source material and the extraction efficiency of the device (which is calculated based on the amount of source material and the amount of active substance delivered), and the extraction efficiency can be, for example, between 10% and 85%, or between 30% and 80%, or between 40% and 75%, such as 40%, 60%, 75% or intermediate, higher or lower efficiencies. For example, at an extraction efficiency of 50%, each segment can accommodate between 100 and 300 milligrams of nicotine. In embodiments where the device corresponds to a conventional cigarette that can be puffed approximately 10 to 12 times, the device can accommodate a total of between 1 and 3.6 milligrams of nicotine. As the nicotine content may vary between different tobacco strains, the amount of tobacco may also vary. In a first example, for each gram of tobacco, the tobacco accommodates approximately 25 mg of nicotine. In a second example, for each gram of tobacco, the tobacco accommodates approximately 15 mg of nicotine.

[0241] In some embodiments, the amount of source material is equivalent to one or more conventional cigarettes. In an example, a single cartridge includes sufficient source material for between 50 and 120 delivery events (delivered by 50 to 120 puffs or a greater number of puffs), which corresponds to approximately 5 to 10 cigarettes depending on the nicotine content. For example, for tobacco with the aforementioned lower nicotine content, the total amount of source material can include between 1.25 and 2.5 grams of tobacco. For tobacco with a higher nicotine content, the total amount of source material can include between 125 and 250 milligrams of tobacco. Optionally, when using tobacco with a relatively high nicotine content, the total amount in the cartridge can correspond to a greater number of cigarettes.

[0242] In some embodiments, the source material includes approximately 1-10%, 3-7%, 5-8%, 10-20% or intermediate, greater or smaller ranges of nicotine.

[0243] In some embodiments, each source material segment includes at least 5, 10-20, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 30, 40, 50 mg or intermediate, greater or smaller amounts of tobacco.

[0244] In an example, each source material segment includes 15 mg of organic material, such as tobacco. Optionally in this case, a cartridge including 10 source material segments includes a total of 150 mg of organic material.

[0245] Note that materials other than tobacco can be used, and the amounts described herein may be applicable to other plant materials. Alternatively, when using synthetic and / or extracted and / or purified substances, even higher concentrations of active substances can be provided, whereby each individual source material cartridge may provide more delivery events.

[0246] Figure 13A -B shows a device 1308 according to some embodiments, such as shown in Figure 12A -E, which includes a usage progress indicator.

[0247] In some embodiments, the device includes a usage progress indicator configured to indicate one or more of the following: the amount of source material being used; the amount of source material remaining; all source material has been consumed or is about to be consumed; and / or other indications.

[0248] As used herein, a source material (or amount of source material) is considered to have been consumed when the device has used the source material (e.g., by heating the source material and / or by allowing an air flow to pass through it); and / or when the device is configured not to use the source material (even if no active substance is inhaled from it). Optionally, the signal indicates that a given portion of the source material has been consumed. For example, if the device is loaded with a source material comprising tobacco or nicotine intended to replace multiple cigarettes, an indication can be provided separately to indicate that the amount of source material associated with a single cigarette has been consumed, thereby allowing the user to regulate the usage rate.

[0249] In some embodiments, the indicator is configured to provide a visual and / or audible and / or tactile and / or perceptible indication to the user. In an example, the indicator includes a fragrance in the source material that is released only during the last delivery event and / or during the last 2 - 3 inhalations. In another example, the indicator includes a lamp tube. Optionally, heat causes the tube material to deform such that the light guide changes (e.g., a transparent plastic becomes milky due to heat), thereby indicating the usage progress to the user. In some embodiments, the indicator is configured to indicate (e.g., via a color change and / or a light intensity change) the current dose being provided and / or the remaining amount of active substance in the currently used source material segment. In an example, when the user is handling a given source material segment, the indicator lamp turns on. When the user inhales (by one or more inhalations), the indicator lamp dims or flashes to indicate the estimated amount of active substance remaining in the segment. In an example, a high concentration and / or large remaining amount of active substance is associated with one or more of the following: a high light intensity that disappears during use; a high flash rate that slows down during use; a gradual color change of the indicator (e.g., from red to black). Optionally, when loading the next dose, the indicator returns to its pre - inhalation state, e.g., the lamp travels along the indicator, thereby returning the light state to full brightness.

[0250] In some embodiments, the amount of active substance remaining in a segment is calculated based on one or more of the following: the amount and / or concentration of the active substance in the segment; the amount of source material in the segment; the inhalation amount of the user who extracts the active substance from the segment; the inhalation flow rate; the suction force generated by inhalation; the time period during which the segment is heated; the temperature to which the source material is heated; and / or the rate of the air flow passing through the segment.

[0251] In some embodiments, the indicator light is initially turned on at a low brightness and / or a given color, and the brightness increases and / or the color changes when inhalation continues and / or in response to the suction force generated by inhalation. Optionally, the light returns to its low-intensity state and / or returns to the baseline color when inhalation terminates.

[0252] In some embodiments, as shown, for example, in Figure 13A -B, the indicator 1300 includes a light and / or a color marker. Optionally, the indicator 1300 is configured to move in concert with the loading mechanism of the device, such as moving with the pusher block, as shown, for example, in Figure 12A -E (1214). Optionally, the indicator moves from the distal end 1302 of the device towards the proximal end 1304 where the mouthpiece 1306 is located. Optionally, the device housing includes information markings (not shown) corresponding to one or more positions of the indicator 1300. In some embodiments, the physical position of the indicator indicates the remaining source material segment and / or the used source material segment.

[0253] Figure 14 is a flowchart of a general method of delivering at least one substance released from a source material to a user according to some embodiments of the present invention.

[0254] In some embodiments, one or more source material segments are selected for use from a plurality of source material segments (1400). Optionally, the one or more segments are automatically selected by a controller of the inhaler device. Additionally or alternatively, the one or more segments are selected by the user, for example, using a mechanical actuator and / or an electrical actuator (such as a turntable, a slider, a switch, and / or others). Optionally, the segments are sequentially selected in an order determined by their spatial arrangement within the device.

[0255] In some embodiments, different source material segments include different types of materials. Optionally, different types of plant materials are used, such as including tobacco and / or other plant materials listed above.

[0256] In some embodiments, different source material segments include different substance compositions.

[0257] In some embodiments, different source material segments include different amounts of active substances, such as nicotine and / or other active substances.

[0258] In some embodiments, the source material segments are spatially arranged in the cartridge according to their content. For example, a series of source material segments, each including a different amount of active substance, are arranged in such a way that the amount of active substance varies along the cartridge (e.g., decreases and / or increases along the cartridge). Optionally, the variation is related to the composition of the active substance, such as related to the amount of an active substance added to impart flavor and / or aroma in addition to a fixed or variable amount of another active substance (e.g., nicotine). Alternatively, the amount of active substance in each of the plurality of source material segments is constant.

[0259] In some embodiments, the timing and / or sequence of delivery of different materials and / or different amounts of active substances to the user is controlled by the spatial arrangement of the different source material segments relative to each other. Optionally, the segments are used according to their spatial arrangement. Alternatively, the segments are used in an order that does not depend on the spatial arrangement of the segments. Optionally, the segments are used in an order determined by the user. Optionally, the controller sets the order of using the segments based on an input provided by and / or obtained from the user. Alternatively, the segments are used in a predetermined order.

[0260] In some embodiments, a single segment is divided into a plurality of sub-segments, such as 2, 3, 5, 10 sub-segments. Optionally, only a portion of these sub-segments are selected for use.

[0261] In some embodiments, a subset of the plurality of source materials is selected. Optionally, different subsets of the segments are selected for use each time an inhalation is made and / or during each use of the device (e.g., a use process including multiple inhalations).

[0262] In some embodiments, an air flow path (1402) is created between one or more selected source material segments and the output to the user. In some embodiments, creating the air flow path includes: modifying the state of an existing path leading to the selected segment from a state that does not allow air flow through the path to a state that allows at least some air flow through the path. In some embodiments, the modification includes: forming a fluid connection between the selected source material segment and the user, such as by removing an obstruction in the path, aligning misaligned portions of the path, switching valves, and / or other actions suitable for providing air flow to and through the source material of the selected segment, into the path, and to the user.

[0263] In some embodiments, once air flow is allowed through the source material, at least one active substance is released from the source material (1404). Optionally, the active substance is released by evaporation of the source material. In some embodiments, a heating element associated with a section of the source material is activated to heat the selected section of the source material, for example by electrically coupling the heating element to a power source.

[0264] In some embodiments, the heating of the source material and the generation of the air flow path are coordinated. Optionally, heating is initiated before allowing air flow, for example, up to 2 minutes, 1 minute, 30 seconds, 25 seconds, 20 seconds, 15 seconds, 10 seconds, 5 seconds, 2 seconds and / or intermediate, longer or shorter time periods before allowing air flow. Optionally, heating is terminated before generating the air flow path.

[0265] Alternatively, heating is initiated after generating the air flow path, for example 1 millisecond, 10 milliseconds, 500 milliseconds, 1 second, 5 seconds, 10 seconds or less after defining the air flow path.

[0266] Optionally, heating is initiated before generating the air flow path and increased after generating the air flow path.

[0267] Additionally or alternatively, heating is initiated or increased in response to a user action, such as in response to inhalation through the device.

[0268] In some embodiments, the controller of the inhaler device coordinates the timing of the generation of the air flow path (e.g., by removing an obstruction to the air flow path) with the heating of the source material. Optionally, the controller is programmed using one or more protocols defined according to one or more of the following: the type of source material used; the type of active substance extracted; user profiles and requirements and / or others.

[0269] In some embodiments, the timing of heating is determined based on sensing of the air flow, for example in response to indications received from a flow rate sensor, a pressure sensor and / or other flow-related indications. Optionally, heating is automatically initiated or increased in response to flow-related indications received from one or more sensors. Additionally or alternatively, heating is initiated or increased by manual operation of the device by the user.

[0270] In some embodiments, the released (e.g., evaporated) substance is then delivered to the user (1406). Optionally, air that is drawn into the inhaler, optionally in response to the user's inhalation, is passed through the source material of the selected section and into the formed air flow path and reaches the user, for example via the mouthpiece. In some embodiments, the air flow reaching the user includes ambient air that is drawn into the inhaler and entrained with the vapor of the released active substance. Optionally, the air flow path is isolated such that once the air has passed through the section, it can only leave the device via the mouthpiece. Optionally, as long as the user performs inhalation, the air flow containing the substance can only leave the device.

[0271] In some embodiments, after using one or more source material sections, their associated air flow paths are then closed. Alternatively, the air passing through the used source material section (e.g., via the air flow path of the currently used source material section) can contact the used source material.

[0272] In some embodiments, a cartridge is provided that includes a plurality of source material sections and optionally at least a portion of their associated air flow paths, the cartridge being configured to be received within an inhaler device and / or otherwise operatively coupled to the inhaler device. In some embodiments, the cartridge includes an output to the user, for example in the form of a mouthpiece or a mouth. In an example, a tubular mouth is used, which optionally tapers in the direction of the user to facilitate suction. In some embodiments, the cartridge includes an actuator that is configured to unblock the corresponding air flow paths of one or more selected source material sections and / or is configured to activate the heating of the source material of one or more selected sections.

[0273] Figure 15A -B schematically shows the unblocking of the air flow path associated with the selected source material section according to some embodiments.

[0274] In some embodiments, for example as Figure 15A shown, a plurality of source material sections 1500, 1502, 1504 are provided. Optionally, each source material section is associated with a corresponding air flow path 1506, 1508, 1510 that extends between the source material section and the output 1512 to the user 1514. Optionally, the plurality of air flow paths are combined to form a single air flow path before reaching the output 1512. Figure 15A The plurality of air flow paths in are shown in a blocked state that does not allow flow through.

[0275] In some embodiments, during use, for example as Figure 15BAs shown, at least one air flow path, such as 1506, is modified to allow air flow 1516 to pass through. Optionally, the modification includes removing an obstruction from the air flow path, for example by moving a blocking element 1518 to a position where it does not completely block the path. In some embodiments, for example after using a source material section, the air flow path 1506 can be blocked again, for example by moving the blocking element 1518 to a blocking position.

[0276] In some embodiments, each source material section is associated with a heating element configured to heat at least a portion of the source material within the section. In some embodiments, the heating element is in contact with and / or sufficiently close to the source material such that the source material is heated to a temperature sufficient to vaporize at least one active substance from the source material. In an example, the heating element includes a mesh that at least partially contacts the material. Optionally, the mesh defines at least one wall 1520 of the source material section. Optionally, the mesh includes openings through which air is allowed to flow to the openings and / or flow through the source material. A heating element such as described above can be used in addition to or in place of the mesh.

[0277] For example, in some embodiments, the heating element can be constructed of or include one or more of the following resistive materials: for example, doped ceramic semiconductors, "conductive" ceramics (such as molybdenum disilicide), carbon, graphite, metals, metal alloys, and composite materials made of ceramic materials and metal materials. Such composite materials can include doped or undoped ceramics. Examples of suitable doped ceramics include doped silicon carbide. Examples of suitable metals include titanium, zirconium, tantalum, and metals from the platinum group. Examples of suitable metal alloys include stainless steel, nickel-containing alloys, cobalt-containing alloys, chromium-containing alloys, aluminum-titanium-zirconium-containing alloys, hafnium-containing alloys, niobium-containing alloys, molybdenum-containing alloys, tantalum-containing alloys, tungsten-containing alloys, tin-containing alloys, gallium-containing alloys, manganese-containing alloys, and iron-containing alloys, as well as superalloys based on nickel, iron, cobalt, stainless steel, Timetal®, and iron-manganese-aluminum-based alloys. Other materials can include silver, platinum, copper, nickel, and palladium.

[0278] In some embodiments, multiple source material sections are separated from each other by an airtight barrier (e.g., including wall 1522). Optionally, the airtight barrier can be removed or displaced, for example to enable access to two source material sections together.

[0279] In some embodiments, a source material section, such as 1500, is fixed relative to the housing 1524 of the device. Optionally, there is no relative movement between the source material section and the heating element 1520; there is no relative movement between the source material section and its associated air flow path 1506; and / or there is no relative movement between the source material section and one or more structural elements of the device, such as the output 1512 (e.g., the mouthpiece component).

[0280] In some embodiments, the source material layer contained within each section is no more than 1 mm thick, no more than 0.5 mm thick, no more than 2 mm thick, no more than 5 mm thick, or no more than an intermediate, higher, or lower thickness. For example, along the path of air flow through the material, the layer can be between 0.5 - 5 mm, or between 0.5 - 2 mm, or between 0.5 - 1.5 mm.

[0281] Figure 16A -B is an isometric view (16A) and a side view (16B) of an arrangement of source material sections according to some embodiments, the arrangement being configured to provide individual access to each of a plurality of source material sections.

[0282] In some embodiments, the arrangement 1600 includes an array of source material sections 1602. Optionally, the sections are linearly aligned relative to each other, such as as shown herein. It is noted that other arrangements and / or spatial distributions of the plurality of sections are also contemplated. In some embodiments, each section 1602 can be accessed by lifting, shifting, and / or otherwise moving a cover 1604 that blocks the conveyance of air to and through the source material of the section. In some embodiments, the movement of the cover 1604 is magnetically actuated, manually actuated, and / or electrically actuated. In some embodiments, the cover 1604 is pivotally coupled to a hinge.

[0283] In some embodiments, air flowing into an open source material section is conveyed through the source material and into a conduit (whose opening is shown at 1606) for delivery to a user. Optionally, the conduit is a common conduit for a plurality of source material sections.

[0284] Figure 17A -B shows a slidable actuator 1700 according to some embodiments of the present invention, which is configured to unblock at least one air flow path associated with at least one source material section and / or activate a heating element associated with at least one source material section.

[0285] In some embodiments, actuator 1700 moves along housing 1702, e.g., slides along the long axis of the housing, e.g., in the direction shown by arrow 1704, to provide access to one or more selected source material sections beneath housing 1702. In some embodiments, actuator 1700 is configured to displace a cover (e.g., cover 1604 as described above) of the underlying source material section.

[0286] In some embodiments, actuator 1700 is configured to activate a heating element associated with a source material segment, such as by electrically coupling the heating element (eg, a conductive mesh) to a power source such as a battery.

[0287] Additionally or alternatively, in some embodiments, the electrical coupling is actuated in response to inhalation.

[0288] Optionally, the circuit is closed in response to sensing of a flow-related parameter (e.g., pressure or pressure change). Additionally or alternatively, the circuit is closed by movement of a flap, valve, and / or other mechanical element that is displaced in response to air flow. In some embodiments, inhalation causes electrical connection and heating to begin by changing the position of a mechanical element, such as a blade or spring that closes the circuit when moved by sufficient air flow. Other examples of such mechanical elements include bimetallic switches that respond to air flow, electromechanical generators that generate power due to flow, and / or other suitable devices.

[0289] In some embodiments, inhalation is used as a trigger for physical and / or electronic sensors, proximity sensors, and / or light sensors, such as, but not limited to, conductivity of the lips, temperature of the lips, pressure changes due to inhalation, characteristic acceleration caused by movement relative to the earth's gravity. In some embodiments, the sensing of inhalation is performed by a mechanical element such as a blade or spring that changes position to close a circuit when moved by sufficient air flow. Optionally, mechanical sensing of air flow is performed in conjunction with electrical elements and / or electromechanical elements (e.g., conductivity sensors and / or bend sensors). Other examples include bimetallic switches that respond to air flow, electromechanical generators that generate power due to flow, and / or other suitable devices and / or sensors.

[0290] In some embodiments, an actuator is used to connect circuitry to perform the aforementioned coupling, such as via pogo-pins, blade connections, direct current connections, and / or others.

[0291] In some embodiments, for example as described in WO2013060784, which is incorporated herein by reference, an electric heater is actuated based on determining a change in air flow. For example, any sensor capable of detecting air flow can be used. The sensor can be an electromechanical device. Alternatively, the sensor can be any of the following: a mechanical device; an optical device; an opto-mechanical device; a microelectromechanical systems (MEMS)-based sensor; and an acoustic sensor. The sensor can be a thermal conductivity flow sensor, a pressure sensor, and an anemometer. Optionally, the sensor can not only detect air flow but also measure air flow. The sensor can be configured to deliver an analog electrical signal or digital information representative of the magnitude of the air flow.

[0292] In some embodiments, the movement of actuator 1700 is manually performed (e.g., by a user). In some embodiments, the user advances actuator 1700 before and / or during use of the device. Potential advantages of a user-controlled actuator can include allowing the user to control the rate and / or duration and / or amount or active substance being delivered.

[0293] Alternatively, the movement of actuator 1700 is automatically performed, for example according to a predetermined protocol.

[0294] Figure 17A The first side of the device across which actuator 1700 advances is shown; Figure 17B The opposite second side of the device is shown, which includes a plurality of slots 1706 through which air enters the device. The air entering the device can enter the source material section after unblocking an associated air flow path (not shown in this example).

[0295] Figure 18A -D are various structural features of the actuator according to some embodiments, such as as described in Figure 17A -B.

[0296] In some embodiments, the actuator is configured to use magnetic attraction to displace a cover of the source material section. Optionally, as shown for example in Figure 18A the actuator includes one or more magnets 1800 sized, positioned, and having sufficient magnetic force to displace the magnetically attracted cover of the source material section. Figure 18B An actuator structure without magnets is shown.

[0297] In some embodiments, such as Figure 18CAs shown, the actuator includes an electrical connector 1802 configured to close or become part of the circuit of the source material section when the actuator is in place. In some embodiments, closing the circuit activates a heating element to heat the source material of the selected section. In some embodiments, the circuit can only be closed when the cover of the selected source material section is displaced. In some embodiments, the circuit can only be closed when the air flow starts or is greater than a given threshold.

[0298] In some embodiments, the actuator is shaped and / or sized to be positioned on and optionally span a housing that encloses the source material section. In the example shown herein, the actuator includes a rectangular profile sized to span the housing. It should be noted that the actuator can include any other form that is suitable for engaging a blocking element of the source material section during the advancement and / or other movement of the actuator to unblock the element.

[0299] In some embodiments, such as Figure 18D as shown, the actuator includes one or more structural elements, such as ribs 1804, shaped to facilitate manual grasping of the actuator.

[0300] Figure 19A -B shows a camshaft mechanism for using multiple source material sections in a sequential manner according to some embodiments of the present invention. In some embodiments, the camshaft 1900 extends along at least a portion of an array of source material sections 1902 at a position suitable for displacing a cover (not shown) of the source material section. In some embodiments, the lobes 1906 of the camshaft extend to engage the cover such that as the camshaft rotates, the cover is lifted one by one by the lobes, allowing air to flow into and through the source material of the open section.

[0301] Figure 20 shows a deformable access area for selectively accessing one or more source material sections according to some embodiments. In some embodiments, a plate 2000 covers an array of source material sections (not shown). In some embodiments, the plate includes a plurality of access areas 2002 at corresponding positions of the source material sections. In the example, the access areas 2002 are positioned directly above the source material sections. In some embodiments, the access areas 2002 include areas that are not as rigid as the surrounding plate material such that they can be peeled, penetrated, and / or otherwise deformed to allow air to pass through. In some embodiments, the access areas include perforations and / or etched layers.

[0302] In some embodiments, the access area is formed of and / or includes magnetic material so that it can be peeled in response to the pulling of a magnet, the pulling of the magnet being achieved, for example, by advancing a magnet actuator as described above. Optionally, when the magnetic force is no longer applied (e.g., when the actuator advances further), the access area returns to its original closed position.

[0303] In some embodiments, the access area includes one or more of the following: magnetic material; stainless steel; iron sheet; nickel; iron foil and / or others.

[0304] Figure 21A -C shows a mouthpiece for use with an array of source material segments according to some embodiments. In some embodiments, the mouthpiece 2100 (shown in a front view in Figure 21A and in a rear view in Figure 21B is configured to be attached to a frame 2102 (shown in Figure 21C ) of an array of source material segments (not shown here). Optionally, the mouthpiece 2100 is removably attached to the frame 2102, e.g., the mouthpiece can be cleaned and put back. Additionally or alternatively, the mouthpiece 2100 is disposable.

[0305] In some embodiments, a seal, such as in the form of an O-ring (not shown), is provided at the mouthpiece-frame attachment to ensure fluid communication.

[0306] Figure 22 is a cross-sectional view of an arrangement of a plurality of source material segments and dedicated air flow ducts according to some embodiments.

[0307] In some embodiments, the source material is contained within a plurality of slots 2200 defined in a substrate 2202. In some embodiments, one or more air flow paths, such as ducts 2204, extend distally from the slots 2200 to a central air flow outlet 2206.

[0308] In some embodiments, an actuator, such as in the form of a rotary switch further described below, is positioned at the air flow outlet 2206. Optionally, by aligning the opening of the rotary switch with the distal opening of the duct 2204, the duct 2204 is unblocked to allow air flow through the duct and to and through the source material of the selected slot.

[0309] In some embodiments, the switch concomitantly closes the circuit of the selected source material slot to activate heating of the source material. Additionally or alternatively, in some embodiments, the electrical connection is actuated in response to inhalation. Optionally, the circuit closes in response to sensing of flow-related parameters (e.g., pressure, such as pressure or pressure change sensed in response to the user's inhalation through the device). Optionally, closing of the circuit initiates heating. Optionally, the circuit closes due to the mechanical action of the air flow.

[0310] In some embodiments, heating causes the source material to evaporate, and air entraining at least one active substance flows through the air flow outlet 2206 to be delivered to the user (e.g., via one or more additional conduits and a mouthpiece not shown herein).

[0311] In some embodiments, the substrate 2202 is a PCB including an embedded circuit associated with the source material slot. Optionally, the PCB is a flexible PCB. In some embodiments, the substrate 2202 may include a slat and / or not use an adhesive (dead bug configuration). In some embodiments, the substrate 2202 includes materials such as heat-resistant materials and / or inert materials, and the inert materials are, for example, Kapton (polyimide), all-polyimide, mica foil, and / or others.

[0312] Figure 23 is an external view of an arrangement according to some embodiments such as as Figure 22 shown therein.

[0313] This figure shows a housing 2300 containing an arrangement such as as Figure 22 described therein. For illustrative purposes, an empty source material slot 2302 is shown on the right side of the housing, and a slot 2304 covered by a mesh (optionally, already loaded with source material) is shown on the left side of the housing 2300.

[0314] Figure 24A -B is an example of a rotatable actuator for use with an arrangement such as as Figure 22 shown therein according to some embodiments.

[0315] In some embodiments, the rotatable actuator 2400 includes an orifice 2402 through which air can flow. Optionally, after rotation of the actuator, the orifice 2402 is aligned with the distal opening of the air flow conduit leading to the source material section (e.g., the source material slot as described above).

[0316] In some embodiments, the actuator includes an electrical connection positioned to close a circuit with the selected source material section. Optionally, the electrical connection includes spring pins and / or other spring-loaded contacts suitable for establishing a temporary electrical connection with the circuit of the selected source material slot.

[0317] Figure 25A -C shows an apparatus including an arrangement similar to the arrangement shown in Figure 22 .

[0318] In Figure 25C 's cross-sectional view, the substrate 2500 (e.g., a PCB) can be observed, which includes a plurality of source material slots 2502 and their associated conduits 2504. In this example, the slots 2502 are arranged in a geometric pattern different from that of Figure 22 . A central air flow outlet 2506 including a distal opening 2508 of the conduit is shown according to some embodiments without a rotatable actuator. Figure 25B A gripping portion 2510 of a rotatable actuator protruding outward relative to the substrate 2500 is shown, and the actuator is positioned at the air flow outlet 2506. According to some embodiments, a cover 2512 is laminated above the substrate 2500 to block the openings of the slots 2502 from at least one direction. In some embodiments, the distal opening 2508 is blocked and selectively opened by an actuator, such as the rotatable actuator 2400, as shown in Figure 24A -B.

[0319] Figure 25A A fully assembled apparatus is shown according to some embodiments. In some embodiments, the outer housing 2514 includes one or more markings 2516 for indicating the position of the rotatable actuator 2510 to the user.

[0320] Figure 26 An alternative arrangement of a plurality of source material segments and dedicated air flow conduits is shown according to some embodiments. In this example, all the source material slots 2600 defined in the substrate 2602 are linearly aligned with each other. In some embodiments, for example as shown herein, the air flow outlet 2604 is positioned at the proximal end and / or the distal end of the substrate. The air flow conduit 2604 is shown extending from its associated source material slot to the air flow outlet 2604.

[0321] Some embodiments may include more than one main air flow outlet, such as 2, 3, 5 air flow outlets.

[0322] Figure 27A -C shows the use of a shape-changing element to move a source material cover according to some embodiments of the present invention.

[0323] In some embodiments, the shape-changing element includes one or more shape memory materials that deform in response to temperature changes.

[0324] In some embodiments, a shape-changing element, such as deformable body 2700, is positioned to shift, lift, and / or otherwise move cover 2702 of the source material segment to allow air flow therethrough. In some embodiments, deformable body 2700 is configured to deform in response to a change in temperature, such as expanding, bending, and / or straightening in response to an increase in temperature. In some embodiments, deformable body 2700 is configured to return to its initial shape in response to cooling. In some embodiments, deformable body 2700 is positioned adjacent to and / or in contact with or in a position designed to interact with heating element 2704 of the source material segment at that location. Optionally, when heating element 2704 is activated, such as by closing a circuit, deformable body 2700 expands in one or more directions to thereby push cover 2702 into a position that allows air flow through the location where the source material is located, such as as Figure 27B shown. In this example, deformable body 2700 extends longitudinally (i.e., along an axis that is substantially perpendicular to cover 2702 when cover 2702 is closed) in response to heating, thereby lifting at least a portion of cover 2702.

[0325] In some embodiments, the shape-changing element is configured to move, bend, perforate, shift, and / or otherwise affect at least a portion of the cover of the source material segment. In some embodiments, the shape-changing element includes polyurethane foam, shape memory polyurethane, polymers, silicone, thermally responsive materials with associated melting points (e.g., wax), and / or other materials that change their state and / or shape in response to a change in temperature.

[0326] In some embodiments, air flow through the device (e.g., in response to inhalation) causes a temperature change that affects the shape-changing element.

[0327] In some embodiments, in addition to or in place of the shape-changing element for opening the cover, one or more mechanical elements, such as springs, vanes, pins, and / or others, are used.

[0328] In some embodiments, the same shape-changing element (e.g., by using a two-way shape memory material) is used to effect closure of the cover (e.g., after using the source material contained therein). For example, cooling of the deformable body 2700 causes it to return to its initial shape and / or deform again to a shape that allows the cover to return to its initial position. Additionally or alternatively, different shape-changing elements are used, such as a second deformable body positioned adjacent to the cover, to effect closure of the cover. Optionally, the opposing second deformable body expands or contracts in a delayed manner relative to the first deformable body 2700 (e.g., after 0.5 seconds, 1 second, 3 seconds, 4 seconds, or an intermediate, longer, or shorter time period) to close the cover after use of the segment. Optionally, the delay is achieved by using a thermal insulation material and / or by using a fuse, the thermal insulation material slowing the transfer of heat to the second deformable body and the fuse being melted when heat is applied.

[0329] Additionally or alternatively, closure is effected by one or more mechanical elements, such as a spring shaped, sized, and positioned to oppose the expansion of the deformable body.

[0330] In some embodiments, the deformable body includes one or more shape memory materials, such as shape memory polymers (e.g., foams), thermally expanding components, components configured to evaporate thereby causing another component to expand, and others.

[0331] In some embodiments, the cover 2702 includes a silicone foil.

[0332] Figure 28 is an isometric view of an inhaler device 2800 according to some embodiments, the inhaler device 2800 including a linear arrangement of source material segments that are independently accessible.

[0333] In some embodiments, each source material segment includes a cover 2802 configured to open independently relative to one or more other covers. Optionally, the cover 2802 is opened by a shape memory mechanism. In some embodiments, the cover 2802 itself includes a shape memory material that deforms, moves, and / or otherwise changes its shape or position, thereby enabling an air flow to reach and optionally flow through at least a portion of the source material protected by the cover 2802.

[0334] Figures 29A - B are schematic top views of an arrangement 2900 according to some embodiments, in which a fluid having a varying viscosity is used to seal the source material.

[0335] In some embodiments, a fluid (e.g., silicone oil) that varies its viscosity in response to a temperature change provides a seal for the source material that prevents air flow through. Optionally, the fluid with a varying viscosity (indicated by the dark surface in the figures) is disposed across a mesh or other framework 2902 layer that contains the source material. FIG. 29A shows a non-heated (cooled) state according to some embodiments, where the fluid exhibits a high enough viscosity to seal the source material beneath it. Figure 29B A heated state is shown, where the viscosity is reduced, resulting in the fluid flowing via capillary channels 2904 and into one or more side chambers 2906. In some embodiments, the flow of the fluid away from the mesh or framework of the source material exposes the source material to the air flow.

[0336] In some embodiments, the temperature change results in a change in the surface tension of the fluid. Optionally, the change in surface tension and viscosity causes capillary movement of the fluid, which exposes at least a portion of the source material to the air.

[0337] In some embodiments, when heating terminates and the fluid cools down, the fluid spontaneously moves back to cover the exposed area. Optionally, the fluid flows (e.g., through capillary channels) due to a change in the surface tension and / or wetting properties of the fluid.

[0338] Figure 30A -B schematically shows an inhaler device configured to receive a plurality of source material cartridges according to some embodiments.

[0339] In some embodiments, the inhaler device 3000 includes a plurality of recesses, slots, seats, connectors, and / or other structures, each configured to receive one or more source material cartridges. In the example shown, the device 3000 includes an empty seat 3004 and three source material cartridges 3006, 3008, 3010 received in three corresponding seats. Examples of such cartridges may include, for example, the cartridges and / or devices described herein, such as in Figure 8A - 8B 、9、10A - 10F、11B、12C - 12D、16A - 16B、22、23、26、28 and Figure 31A - 31B the cartridges and / or devices in.

[0340] In some embodiments, each cartridge includes a plurality of source material segments 3012. In some embodiments, for example, as shown in cartridge 3006, the plurality of source material segments include the same contents, such as including the same plant or plant components and / or the same active substance or components of the active substance. Alternatively, for example, as shown in cartridge 3010, different source material segments include different contents, such as different plants or plant components and / or different active substances or components of the active substance.

[0341] In some embodiments, a particular cartridge and / or a particular section of source material within the cartridge is processed according to a predetermined scenario. Additionally or alternatively, a particular cartridge and / or a particular section of source material within the cartridge is processed according to a demand, such as being selected by a user according to their needs and / or desires. In this example, Figure 30A shows the selection of a section of source material from cartridge 3006; Figure 30B shows the selection of a section of source material from cartridge 3010.

[0342] In some embodiments, during use, the source material in one or more of the selected sections is heated (e.g., using a heating element such as those described above), and air 3014 that is drawn into the device and / or otherwise enters the device (e.g., via passage 3018) is allowed and / or directed to flow through the material of the selected section. Then, air 3015 entraining the released active substance is delivered to the user via the output 3016 of the device (e.g., including a mouthpiece). In some embodiments, the air entraining the active substance exits the inhaler in response to the user's inhalation. Additionally or alternatively, the device includes a fan or a pressurized air source (not shown) that can augment and / or replace the user's inhalation force.

[0343] In some embodiments, the selected sections differ in their contents such that different active substances or components of active substances are released from each section for delivery to the user. For example, in Figure 30A air 3015 entraining the active substance released from source material section 3012 exits the inhaler device for delivery to the user; in Figure 30B air 3030 entrains a different active substance and / or different components of the active substance (compared to the active substance or components of the active substance released from section 3012 in Figure 30A ) released from source material section 3032.

[0344] In some embodiments, device 3000 includes a controller 3022 that is configured to control the selection of and / or access to one or more particular source material sections and / or access to the selected cartridges. Optionally, two or more sections are accessed simultaneously to obtain a selected amount of active substance, a selected component of the active substance, and / or a selected effect for the patient. Optionally, for each of the multiple sections accessed simultaneously, a different air flow and / or heating scenario is used, thereby affecting the composition or proportion of the active substance in the air flow toward the user.

[0345] Optionally, the controller selects sections that are the same in terms of their contents. Alternatively, the controller selects sections that are different in terms of their contents. Optionally, the controller selects sections from the same cartridge. Alternatively, the controller selects sections from different cartridges.

[0346] In some embodiments, the controller 3022 is configured to select source material segments for use according to a predetermined order (e.g., according to a scenario).

[0347] In addition to or in place of the controller, the device 3000 includes a manual control (e.g., an actuator such as a slider) configured to select the selected segment and / or enable heating of the selected segment and / or enable air flow to the selected segment.

[0348] In some embodiments, the controller and / or the manual control is configured to allow "mixing and matching" of different source material segments based on the contents of the different source material segments.

[0349] In some embodiments, multiple source material segments having different contents from each other are selected for treating a certain medical condition. Examples of active substance components and medical conditions that can potentially be treated with the active substance may include: active agents that provide a synergistic effect; active agents that provide the same effect but each have different advantages or disadvantages; active agents that enhance or weaken another or other active agents (e.g., changing each other's effective treatment window or therapeutic index); active agents that provide contradictory effects, such as THC neutralizing with CBD; and active agents that have a neutralizing but desired effect and need to be spaced apart from each other.

[0350] According to embodiments of the present disclosure, some combinations of active agents that can be effectively delivered using the devices provided herein include, but are not limited to: nicotine and THC, caffeine and THC, and CBD and THC. Some combinations are intended for recreational use and may include combining or varying between: different tobacco blends, tobacco with different added active substances, different plant materials for other plants, and any combination thereof.

[0351] In some embodiments, the selection of multiple source material segments is performed to precisely control the amount of active substance provided, e.g., by using different source material segments that include different amounts of the active substance. For example, a first source material segment including 5 mg of the active substance can be delivered together with a second source material segment including only 1 mg of the active substance to achieve an exact total amount of 6 mg of the active substance.

[0352] In some embodiments, the device 3000 includes a communication module 3024. Optionally, the communication module is configured to send data to and / or receive data from one or more of the following: a user input device; a database; a memory; an online data source; a doctor and / or others. Optionally, the selection of the source material segments for use is performed according to instructions received via the communication module. In some embodiments, the data received from the user input device includes feedback on the effect of the treatment. Optionally, the feedback is collected by one or more sensors of the user input device. In some embodiments, the treatment is controlled according to the received feedback data (e.g., adjusted from a predetermined protocol).

[0353] Figure 31A -B schematically shows an air flow scheme through a device including a plurality of source material segments according to some embodiments.

[0354] In some embodiments, the device 3100 includes one or more inlet conduits 3102, and the incoming air flow 3112 entering the device flows through the inlet conduits to and through the open source material segments 3104. As shown, the flow 3130 of the active substance entrained from the source material flows from the segment 3104 through the carrier conduit 3103 extending to the mouthpiece member 3106 for delivery to the user. In some embodiments, the device includes a bypass conduit 3108 that joins the carrier conduit 3013 without passing through the source material, e.g., at the junction 3105. Alternatively, in some embodiments, the bypass conduit 3108 extends directly to the mouthpiece member 3106 separately from the carrier conduit 3103.

[0355] In some embodiments, a valve 3110 is positioned at the opening of the bypass conduit to regulate the incoming flow into the bypass conduit. In use, the flow into the bypass conduit is regulated in response to the carrier air flow through the device (e.g., through the selected source material segments). Optionally, as Figure 31A shown, the valve 3110 remains closed when the rate of the incoming air flow 3112 is within a predetermined range. In the case where the rate of the incoming air flow is higher than the threshold, as Figure 31B shown, the valve 3110 opens to divert at least a portion 3132 of the incoming air flow 3112 to the bypass conduit. In some embodiments, the rate, velocity, volume, and / or pressure of the incoming air flow are determined by a sensor 3114.

[0356] In some embodiments, an inhalation below the threshold will not trigger the heating of the source material. Optionally, in such a case, an indication (e.g., a visible and / or audible and / or perceptible indication) is provided to the user to increase the inhalation force.

[0357] In some embodiments, device 3110 is a stand-alone device. Alternatively, device 3110 forms a cartridge that is received within an inhaler device. Optionally, in the latter case (when device 3110 serves as a cartridge), bypass conduit 3108 (with or without valve 3110 and / or sensor 3114) forms part of the inhaler device rather than part of the cartridge. Alternatively, bypass conduit 3108 is part of the cartridge.

[0358] In some embodiments, valve 3110 is automatically operated, e.g., by a controller. Optionally, the position of valve 3110 is set based on a flow-related indication received from sensor 3114. Additionally or alternatively, valve 3110 mechanically opens at a given flow rate.

[0359] The terms "comprises", "comprising", "includes", "including", "has" and variations thereof mean "including but not limited to".

[0360] The term "consisting of" means "including and limited to".

[0361] The term "consisting essentially of" means that the composition, method or structure may include additional components, steps and / or parts, but only if the additional components, steps and / or parts do not materially alter the basic and novel characteristics of the claimed composition, method or structure.

[0362] As used herein, the singular forms "a", "an" and "the" include plural references unless the context clearly dictates otherwise. For example, the term "a complex" or "at least one complex" may include multiple complexes, including mixtures thereof.

[0363] Throughout this application, various embodiments of the invention may be presented in range format. It should be understood that the description in range format is merely for convenience and brevity and should not be construed as imposing a fixed limitation on the scope of the invention. Thus, the description of a range should be considered to have specifically disclosed all the possible sub-ranges and individual numerical values within that range. For example, a description of a range such as from 1 to 6 should be considered to have specifically disclosed sub-ranges such as from 1 to 3, from 1 to 4, from 1 to 5, from 2 to 4, from 2 to 6, from 3 to 6, etc., and individual numerical values within that range, e.g., 1, 2, 3, 4, 5, and 6. This applies regardless of the width of the range.

[0364] Whenever a numerical range is indicated herein, it is intended to include any recited numerical value (fractional or integral) within the indicated range. The phrases “range between” a first recited value and a second recited value and “range from” a first recited value “to” a second recited value are used interchangeably herein, and are intended to include the first and second recited values and all fractional and integral numerical values therebetween.

[0365] As used herein, the term “method” refers to a way, means, technique and procedure for accomplishing a given task, which includes but is not limited to those ways, means, techniques and procedures known to those skilled in the fields of chemistry, pharmacology, biology, biochemistry and medicine, or those that are readily developed from those ways, means, techniques and procedures known to those skilled in these fields.

[0366] As used herein, the term “treatment” includes eliminating, substantially inhibiting, slowing down or reversing the development of a disorder, significantly improving the clinical or aesthetic symptoms of a disorder or substantially preventing the appearance of the clinical or aesthetic symptoms of a disorder.

[0367] It is to be understood that certain features of the invention that are described in the context of separate embodiments may also be provided in combination in a single embodiment. Conversely, various features of the invention that are described in the context of a single embodiment may also be provided separately or in any suitable sub-combination or in any other described embodiment of the invention in a suitable manner. Certain features described in the context of various embodiments should not be considered essential features of those embodiments unless the embodiment cannot operate without these elements.

Claims

1. A source material cartridge, the source material cartridge comprising: one or more sealed segments, each segment comprising a source material capable of releasing at least one active substance from the source material by evaporation, wherein the one or more sealed segments are associated with dedicated heating elements configured to heat the source material, and wherein each of the one or more sealed segments comprises a temperature-sensitive sealant, and the heating element is configured to heat the sealant to unseal the source material within the sealed segment; a carrier conduit for conducting an air stream through the source material of the source material segment when at least one source material segment is unsealed; and a bypass conduit that does not pass through the source material segment; wherein the flow through the bypass conduit is regulated in response to the flow through the carrier conduit.

2. The source material cartridge according to claim 1, wherein, the flow through the bypass conduit is regulated in response to the rate of flow of the source material through the at least one unsealed source material segment.

3. The source material cartridge according to claim 1, wherein, the bypass conduit joins the carrier conduit at a junction located outside the location of the one or more sealed segments.

4. The source material cartridge according to claim 1, wherein, the sealed segments are separated from each other by an airtight barrier.

5. The source material cartridge according to claim 1, wherein, the sealed segments are linearly arranged along a long axis, and the cartridge is shaped as an elongated strip.

6. The source material cartridge according to claim 1, the source material cartridge comprising a housing that encloses the one or more sealed segments, the carrier conduit, and the bypass conduit.

7. The source material cartridge according to any one of claims 1 to 6, the source material cartridge comprising a housing including a valve positioned at an opening of the bypass conduit, the valve regulating the incoming flow into the bypass conduit.

8. The source material cartridge according to claim 7, wherein, when the rate of the incoming air flow is higher than a threshold, the valve opens to shunt at least a portion of the incoming air flow to the bypass conduit.

9. The source material cartridge according to any one of claims 1-6, the source material cartridge further comprising a mouthpiece, wherein, the carrier conduit extends to the mouthpiece.

10. The source material cartridge according to claim 9, wherein, the one or more sealed segments comprise a plurality of source material segments, and wherein the carrier conduit comprises dedicated air flow conduits, each of which is associated with at least one of the plurality of source material segments.

11. The source material cartridge according to claim 9, wherein, the bypass conduit extends directly to the mouthpiece.

12. The source material cartridge according to claim 9, wherein, in response to inhalation by a user through the mouthpiece, an air flow is drawn into the cartridge.

13. The source material cartridge according to any one of claims 1 to 6, the source material cartridge comprising a sensor configured to measure a flow-related indication, wherein, Adjust the flow through the bypass conduit in response to the flow-related indication.

14. The source material cartridge according to claim 1, wherein, the heating element includes a mesh or perforated foil in thermal contact with the source material.

15. The source material cartridge according to claim 1, wherein, the heating element is electrically connectable to a power source.

16. The source material cartridge according to any one of claims 1 to 6, wherein, the source material layer within each sealed section includes an air-permeable solid tray that includes a single mass of particulate matter.

17. The source material cartridge according to claim 16, wherein, the tray is no more than 1 mm thick.

18. The source material cartridge according to any one of claims 1 to 6, wherein, the source material includes plant material.

19. The source material cartridge according to claim 18, wherein, the plant material in at least one of the sealed sections includes nicotine.

20. The source material cartridge according to any one of claims 1 to 6, the source material cartridge includes an actuator that is movable relative to the one or more sealed sections, the actuator being configured to open the sealant of the one or more sealed sections to allow air flow through.

21. A device configured to deliver at least one active substance released from a source material by inhalation, the device comprising: one or more source material sections in which the source material is protected by an air-impermeable sealant that includes a control area for opening at least one opening through the sealant, wherein the control area of the sealant is temperature-sensitive; a flow arrangement configured to direct an air flow through one or more of the sections to a user of the device; and an actuator aligned with the control area of the sealant and with the flow arrangement to selectively open the at least one opening through the sealant at the section to allow air to flow through the source material, wherein the actuator includes a heating element configured to heat the sealant to open the at least one opening.

22. The device according to claim 21, the device further comprising a power source.

23. The device according to claim 21, wherein, the source material section is contained in a cartridge that is received within the device.

24. The device according to any one of claims 21 to 23, wherein, the actuator includes an air flow element configured to apply the pressure generated by inhalation to the control area of the sealant to open the at least one opening.

25. The device according to any one of claims 21 to 23, wherein, the actuator includes an electrode group configured to apply electricity to the control area of the sealant to open the at least one opening.

26. The device according to any one of claims 21 to 23, wherein, the actuator is movable relative to the one or more source material sections.

27. The device according to claim 26, wherein, the actuator is configured to slide, roll, and / or be dragged relative to the source material section.

28. The device according to any one of claims 21 to 23, the device comprising a progress indicator configured to indicate one or more of: the amount of source material section used; the amount of source material section remaining; the amount of source material remaining in the section; all source material sections have been consumed; and a given portion of the source material section has been used.

29. The device according to claim 28, wherein, the device has an elongated configuration, and wherein the progress indicator is configured to move along at least a portion of the length of the device.

30. The device according to claim 28, wherein, the progress indicator is configured to move when a new source material section is loaded, the loading being performed automatically and / or manually by a user.

31. The device according to claim 28, wherein, the progress indicator includes one or more of a light indicating device and a color indicating device.

32. A source material cartridge configured for use with an inhaler device, the cartridge comprising: one or more sections comprising a source material; the source material comprising at least one active substance capable of being released by evaporation; the source material being arranged to allow an air flow to pass therethrough; wherein the source material is protected by an air-impermeable sealant comprising a control region that is temperature-sensitive so as to open at least one opening through the sealant during use of the inhaler device to allow air flow through the source material of one or more selected sections to deliver the at least one active substance to a user.

33. The cartridge according to claim 32, wherein, when the cartridge includes one or more ducts, air entraining the drug flows through the ducts to be delivered to the user such that when the cartridge is received within the inhaler, the air entraining the drug only flows through the cartridge, thereby eliminating residues in the inhaler.

34. The cartridge according to any one of claims 32 to 33, wherein, the sealant is configured to open the at least one opening due to being heated.

35. The cartridge according to any one of claims 32 to 33, wherein, the sealant is configured to heat the source material.

36. The cartridge according to any one of claims 32 to 33, wherein, the cartridge includes only one source material section formed as an elongated tray, and wherein the amount of active substance released from at least a portion of the tray is set by controlling the air flow to at least a portion of the tray.

37. The cartridge according to any one of claims 32 to 33, wherein, the cartridge includes a plurality of source material sections separated from each other by at least one of a thermal insulator and an electrical insulator.

38. The cartridge according to any one of claims 32 to 33, wherein, the temperature-sensitive material includes a shape memory material.

39. The cartridge according to claim 38, wherein, the shape memory material comprises one or more of the following: nitinol, Cu-Al-Ni alloy, Fe-Mn-Si-Cr-Ni alloy, Cu50Zr50.

40. The cartridge according to claim 38, wherein, the shape memory material has a bi-directional shape memory effect such that the sealant in the control region deforms in response to a second temperature change to reseal the at least one opening.

41. The cartridge according to any one of claims 32 to 33, wherein, the control region includes an etched scaly pattern, wherein the scales deform to allow air to pass through.

42. The cartridge according to any one of claims 32 to 33, wherein, the control region is configured to expand or contract in response to a temperature change, bend or straighten in response to a temperature change, and / or shift in response to a temperature change.

43. An apparatus configured to deliver at least one substance released from a source material to a user, the apparatus comprising: a frame including one or more source material segments of the source material cartridge according to any one of claims 1-20; a mouthpiece component; and a conduit configured to conduct the substance through at least one of the segments to the user, the conduit extending between at least one of the source material segments and the mouthpiece component.

44. The apparatus according to claim 43, wherein, the frame is shaped and sized to engage an inhaler device.

45. The apparatus according to claim 43 or 44, wherein, the at least one source material segment and the conduit are sealed such that only an air flow is permitted to flow through the at least one segment and the conduit.

46. The apparatus according to claim 43 or 44, the apparatus including an air flow element adapted to direct an air flow through the source material or a selected portion of the source material in the one or more source material segments.

47. The apparatus according to claim 46, wherein, the air flow element includes one or more conduits and / or valves.

48. The apparatus according to claim 43 or 44, wherein, the frame includes the conduit, and wherein the mouthpiece component is configured to be removably attached to the frame.

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