System of fully automatic sampling tube cap screwing and pipetting workstation and operation method thereof

The fully automated sampling tube capping and pipetting workstation system automates the collection and transfer of liquids from multiple sampling tubes, solving the problems of cumbersome operation and low efficiency in existing technologies, and improving the efficiency and accuracy of laboratory testing.

CN114720709BActive Publication Date: 2025-10-17GUOKE RONGZHI (SHENZHEN) BIOENGINEERING TECH CO LTD
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Patent Information

Application Number
CN202210339771.8
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2022-04-01
Publication Date
2025-10-17
Estimated Expiration
2042-04-01

AI Technical Summary

Technical Problem

Existing pipetting devices are cumbersome and inefficient when testing liquid samples from multiple sampling tubes, and require significant manual labor from laboratory personnel.

Method used

A fully automated sampling tube capping and liquid transfer workstation system was designed, including an execution module and a control module. Through a stage, a beam mechanism and an operating body, it realizes automated sampling of sample liquid from multiple sampling tubes and placement into a nucleic acid extraction reagent plate. It is equipped with a capping device and a liquid extraction device, which automatically opens or tightens the caps and transfers the liquid to the reagent plate through the liquid extraction device.

Benefits of technology

It has enabled automated operation of liquid samples from multiple sampling tubes, improving work efficiency, reducing manual labor intensity, and simplifying operation.

✦ Generated by Eureka AI based on patent content.

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Abstract

The application relates to a full-automatic sampling tube cap screwing and liquid transferring workstation system, which comprises an execution module and a control module used for controlling the execution module, the execution module comprises a carrier table, a cross beam mechanism installed on the carrier table and an operation main body arranged on the cross beam mechanism and capable of sliding along the cross beam mechanism, the control module controls the carrier table and the operation main body in the execution module to correspond to each other, so that the operation main body can correspondingly sample sample liquid in a plurality of sampling tubes on the carrier table and correspondingly place the sampled sample liquid into a nucleic acid extraction reagent plate, and a running method of the full-automatic sampling tube cap screwing and liquid transferring workstation system is disclosed. The full-automatic sampling tube cap screwing and liquid transferring workstation system controls the execution module through the control module, so that the operation main body can sample sample liquid in a plurality of sampling tubes on the carrier table, automation operation is realized, and work efficiency is improved.
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Description

TECHNICAL FIELD

[0001] The present application relates to a medical biological field sample liquid collection pipetting device, in particular to a full-automatic sampling tube cap rotating pipetting workstation system and its operation method. BACKGROUND

[0002] In the detection work in the medical, biochemical and other fields, the sample liquid collected into the sampling tube needs to be pumped by the pipetting device before detection and processing. The current pipetting device is mostly single tube collection structure, that is, a certain volume of liquid in the sampling tube is pumped into the pipetting suction head by a single pipetting suction head, so as to analyze and test the liquid in the pipetting suction head. When multiple sampling tubes need to be tested and detected respectively, the workload is large, the manual operation efficiency of the tester is low, and the operation is complicated. Therefore, it is necessary to improve the sample liquid collection technology. SUMMARY

[0003] The present application aims to provide a full-automatic sampling tube cap rotating pipetting workstation system and its operation method, so as to realize automatic operation, improve work efficiency and reduce manual work intensity.

[0004] In order to achieve the above-mentioned purpose, the technical scheme of the present application is as follows: a full-automatic sampling tube cap rotating pipetting workstation system, comprising an execution module and a control module for controlling the execution module, the execution module comprising a worktable, a crossbeam mechanism installed on the worktable, and an operation main body arranged on the crossbeam mechanism and slidable along the crossbeam mechanism, the control module controls the positions of the worktable and the operation main body in the execution module to correspond to each other, so as to correspondingly sample the sample liquid in multiple sampling tubes on the worktable by the operation main body, and correspondingly place the sampled sample liquid into a nucleic acid extraction reagent plate.

[0005] As a further improvement, the operation main body comprises a cap rotating device and a liquid pumping device, the cap rotating device comprising a main driver installed on a main body plate of the operation main body, a lifting mechanism driven by the main driver to slide along the main body plate, a cap rotating mechanism connected to the lifting mechanism, and a cap holder tray mechanism installed at the lower part of the main body plate, the liquid pumping device comprising a first driver installed on the main body plate, a liquid pumping lifting mechanism connected to the first driver, a liquid pumping mechanism arranged on the liquid pumping lifting mechanism, a liquid drop prevention tray mechanism arranged at the lower part of the main body plate, and a telescopic mechanism arranged at the side of the liquid pumping mechanism to drive the liquid pumping mechanism to extend and retract.

[0006] As a further improvement, the lifting mechanism comprises a track, a lifting assembly arranged on the track, and a slave driver for driving the lifting assembly to slide along the track, the track is two and vertically arranged on the main plate, the lifting assembly comprises a lifting plate, a push plate arranged on the lifting plate, and a connecting plate, the lifting plate is slidably arranged on the two tracks, the push plate is connected with the driving screw, and the connecting plate is provided with a through hole for the driving screw to pass through and be connected with the push plate.

[0007] As a further improvement, the motor of the first driver is arranged on the main plate, one end of the screw of the first driver is connected with the rotating shaft of the motor, and the other end of the screw of the first driver is connected with the liquid pumping lifting mechanism, the liquid pumping lifting mechanism comprises two slides vertically arranged on the main plate, a liquid pumping lifting plate slidably arranged on the two slides, and a liquid pumping connecting plate arranged on the liquid pumping lifting plate, and the screw of the first driver is connected with the liquid pumping connecting plate.

[0008] As a further improvement, the slave driver comprises a driven motor and a driven screw connected with the rotating shaft of the driven motor, the driven motor is arranged on the connecting plate, the lifting plate is provided with a driven driving block, the driven driving block is connected with the driven screw of the slave driver, the driven motor drives the driven screw to rotate, so as to drive the driven driving block to move, and then drive the lifting plate and the cap screwing mechanism to slide, so as to simultaneously automatically open or screw the caps of the sample tubes by the cap screwing mechanism and the plurality of cap chuck assemblies on the cap screwing mechanism.

[0009] As a further improvement, the liquid pumping mechanism comprises a liquid pumping driver, a liquid pumping sliding assembly connected with the liquid pumping driver, and a liquid pumping device connected with the liquid pumping sliding assembly, and the telescopic mechanism is arranged on the side of the lower end of the frame of the liquid pumping mechanism, so as to drive the liquid pumping device to relatively contract.

[0010] As a further improvement, the cross beam mechanism comprises support arms connected with the two ends of the object table and a cross beam body arranged on the two support arms, the operation main body further comprises a main plate and a sliding assembly arranged on one side of the main plate, and the sliding assembly of the operation main body is connected with the cross beam body, so as to control the operation main body to slide along the cross beam body by the control module.

[0011] As a further improvement, the object table comprises a bottom plate, an object carrier arranged on the bottom plate and movable along the bottom plate, and a driving mechanism for driving the object carrier to move along the bottom plate, the object carrier is used to carry the devices of the sampling liquid, and the driving mechanism is controlled by the control module to drive the object carrier to slide along the bottom plate.

[0012] The application also discloses a running method of the system of the full-automatic sampling tube cap screwing and liquid pumping workstation.

[0013] S1. The used instruments for sampling liquid are placed on the carrier racks of the carrier table respectively, and the control module controls the carrier table and the operation body of the execution module to work, and adjusts the positions of the carrier racks and the operation body to correspondingly match;

[0014] S2. The control module controls the operation body of the execution module to slide along the beam mechanism to above the pipette tip carrier, and controls the pipetting mechanism of the pipetting device to clamp a plurality of pipette tips from the carrier rack and then slide to a preset position;

[0015] S3. The control module controls the operation body of the execution module to slide along the beam mechanism to above the sampling tube carrier, and controls the cap opening mechanism of the cap opening device to simultaneously open the caps of a plurality of sampling tubes, and the cap tray mechanism moves to the lower part of the cap opening mechanism;

[0016] S4. The control module controls the operation body of the execution module to slide along the beam mechanism to above the pipette tip carrier, and controls the pipetting mechanism of the pipetting device to slide upward to a preset position after completing pipetting in the sampling tube, and the anti-dripping tray mechanism moves to the lower part of the pipetting mechanism; S5. The control module controls the operation body of the execution module to slide along the beam mechanism to above the sampling tube carrier, and controls the cap tray mechanism of the cap opening device to return to the original position, and the cap opening mechanism simultaneously caps the caps of a plurality of sampling tubes;

[0017] S6. The control module controls the operation body of the execution module to slide along the beam mechanism to above the pipette tip carrier, and controls the telescopic mechanism of the pipetting device to drive the pipetting mechanism to clamp the pipette tips to relatively move and adjust the spacing between the clamped pipette tips, so that each pipette tip corresponds to a cavity of the nucleic acid extraction reagent plate;

[0018] S7. The control module controls the anti-dripping tray mechanism of the pipetting device to return to the original position, and controls the pipetting mechanism to drive the liquid in the pipette tip to spray into the cavity of the reagent box;

[0019] S8. The control module controls the anti-dripping tray mechanism to move to the lower part of the pipetting mechanism, and the telescopic mechanism drives the pipetting mechanism to clamp the pipette tips to relatively move and adjust the spacing between the pipette tips, so that each pipette tip corresponds to another pipette tip carrier, the anti-dripping tray mechanism returns to the original position, and the pipetting mechanism drives the pipette tips to fall into the pipette tip carrier, to complete a fully automatic sampling process of the sample liquid.

[0020] As a further improvement, the instruments used for sampling liquid in S1 include a sampling tube carrier loaded with a plurality of sampling tubes, two pipette tip carriers, and a plurality of nucleic acid extraction reagent plates, each sampling tube is loaded with liquid to be tested, one of the pipette tip carriers is built-in and loaded with a plurality of unused pipette tips, the other pipette tip carrier is loaded with pipette tips after use, and the nucleic acid extraction reagent plate is used to store the liquid to be tested.

[0021] The above technical scheme of the present application has the following beneficial effects: the system of the full-automatic sampling tube cap screwing and liquid transferring workstation of the present application controls the execution module by the control module to adjust the position of the carrier rack in the carrier table to correspond to the operation body, and drives the operation body to slide along the cross beam mechanism, the operation body samples the sample liquid in the plurality of sampling tubes, realizes automatic operation, improves work efficiency, and reduces the labor intensity. BRIEF DESCRIPTION OF DRAWINGS

[0022] Figure 1 It is a system module schematic diagram of the full-automatic sampling tube cap screwing and liquid transferring workstation of the present application;

[0023] Figure 2 It is a whole structure schematic diagram of the full-automatic sampling tube cap screwing and liquid transferring workstation of the present application;

[0024] Figure 3 It is Figure 2 It is another perspective structure schematic diagram of the opening cover 43;

[0025] Figure 4 It is an internal structure schematic diagram of the full-automatic sampling tube cap screwing and liquid transferring workstation of the present application;

[0026] Figure 5 It is Figure 4 It is another perspective structure schematic diagram of the opening cover 43;

[0027] Figure 6 It is Figure 5 It is another perspective structure schematic diagram of the opening cover 43;

[0028] Figure 7 It is Figure 5 It is another perspective structure schematic diagram of the opening cover 43;

[0029] Figure 8 It is a structure schematic diagram of the clamping device 24 in the carrier table 20 of the present application;

[0030] Figure 9 It is a structure enlarged schematic diagram of the operation body 40 of the present application;

[0031] Figure 10 It is Figure 9 It is another perspective structure schematic diagram of the opening cover 43;

[0032] Figure 11 It is Figure 9 It is another perspective structure schematic diagram of the opening cover 43;

[0033] Figure 12 It is an internal structure schematic diagram of the gear box assembly 532 of the cap screwing device 50 in the operation body 40 of the present application. DETAILED DESCRIPTION

[0034] The embodiments of the present application will be described in detail below with reference to the accompanying drawings and examples.

[0035] Please refer to Figures 1 to 12 As shown in the drawings, a full-automatic sampling tube cap screwing pipetting workstation system is provided to automatically unscrew multiple sampling tubes and aspirate the liquid in the sampling tubes for analysis and testing, so as to realize full-automatic operation, improve work efficiency and testing accuracy.

[0036] Please refer to Figures 1 to 4 As shown in the drawings, the workstation system comprises an execution module 200 arranged in a machine body 10 and a control module 100 arranged outside the machine body 10. The execution module 200 comprises a worktable 20, a crossbeam mechanism 30 mounted on the worktable 20, and an operation body 40 arranged on the crossbeam mechanism 30 and slidable along the crossbeam mechanism 30. The operation body 40 comprises a cap screwing device 50 and a liquid aspirating device 60. The worktable 20 is provided with a sampling tube carrier 201, two pipetting tip carriers 202, and a plurality of nucleic acid extraction reagent plates 203. The sampling tube carrier 201 is internally provided with a plurality of sampling tubes 2011, each of which contains liquid to be tested. One of the pipetting tip carriers 202 is internally provided with a plurality of unused disposable pipetting tips 2021, and the other pipetting tip carrier 202 is arranged to place used disposable pipetting tips 2021. The nucleic acid extraction reagent plates 203 are used to store the liquid to be tested for testing. The operation body 40 slides along the crossbeam mechanism 30, the liquid aspirating device 60 clamps the corresponding unused disposable pipetting tip 2021 from the pipetting tip carrier 202, the cap screwing device 50 automatically opens the cap on the opening of the sampling tube 2011, the liquid aspirating device 60 drives the unused disposable pipetting tip 2021 to be inserted into the sampling tube 2011 to aspirate a certain volume of liquid, and then the disposable pipetting tip 2021 is removed from the sampling tube 2011. The cap screwing device 50 screws the cap on the opening of the sampling tube 2011. The operation body 40 slides along the crossbeam mechanism 30, so that the liquid aspirating device 60 aspirates the liquid in the pipetting tip 2021 above the nucleic acid extraction reagent plate 203, and then the liquid to be tested in the pipetting tip 2021 is placed into the nucleic acid extraction reagent plate 203. The liquid aspirating device 60 drops the used disposable pipetting tip 2021 into the other pipetting tip carrier 202, so as to complete the full-automatic sampling process of the sample liquid.

[0037] Please refer to Figure 3 As shown in the drawings, the machine body 10 is externally provided with a power connection end 13 and a control module 100. The power connection end 13 is connected with a power supply, and the control module 100 controls the work of the worktable 20 and the operation body 40 in the execution module 200. The machine body 10 comprises a machine shell 11 and a door plate 12 mounted on the machine shell 11 and slidable relative to the machine shell 11. The machine shell 11 forms a working area of the workstation.

[0038] Referring to Figures 4 to 8 As shown in the figure, the object carrier 20 is arranged in the body 10, the object carrier 20 comprises a bottom plate 21, an object rack 22 arranged on the bottom plate 21 and movable along the bottom plate 21, a driving mechanism 23 for driving the object rack 22 to move along the bottom plate 21, and a clamping device 24 arranged on the object rack 22 for positioning the pipette tip carrier 202.

[0039] Referring to Figure 7 As shown in the figure, the bottom plate 21 is arranged in the body 10 and placed in the working area formed by the shell 11. In this embodiment, shock-absorbing rubber blocks 211 are installed at the lower four corners of the bottom plate 21 to reduce the vibration of the workstation during operation. The object rack 22 is movably arranged on the bottom plate 21 to carry the sample tube carrier 201, the pipette tip carrier 202, and several nucleic acid extraction reagent plates 203. The object rack 22 comprises an object plate 221, guide slides 222 formed at both ends of the object plate 221, and guide wheels 223 arranged at the lower part of the object plate 221.

[0040] The object plate 221 is provided with a first accommodating groove, a second accommodating groove, and a third accommodating groove. The first accommodating groove is used to carry the sample tube carrier 201, the second accommodating groove is used to carry the pipette tip carrier 202, and the third accommodating groove is used to carry the nucleic acid extraction reagent plate 203. An activity hole 2211 is formed at the end of the second accommodating groove on the object plate 221, and guide holes are arranged at the four corners of the second accommodating groove for cooperating with the clamping device 24.

[0041] The two guide slides 222 are correspondingly connected at both ends of the object plate 221 to move on the bottom plate 21 by the driving mechanism 23 driving the guide slides 222 cooperating with the guide wheels 223 at the lower part of the object plate 221.

[0042] The driving mechanism 23 is arranged on the bottom plate 21 to drive the object rack 22 to move along the bottom plate 21, thereby adjusting the position of the object rack 22 to accurately cooperate with the operation body 40. The driving mechanism 23 comprises two parallel arranged guide assemblies 231, a motor 232, a lead screw 233 connected with the motor shaft, mounting seats 234 arranged at both ends of the lead screw 233, and guide slides 235 connected on the lead screw 233.

[0043] Each guide assembly 231 comprises a mounting plate 2311 and two linear guides 2312 arranged inside the mounting plate 2311, the two linear guides 2312 are oppositely arranged to correspondingly match the two guide slides 222, the guide slide 235 is engaged with the lead screw 233, one end of the guide slide 235 is connected with one of the guide slides 222, the motor 232 is mounted on the bottom plate 21, two mounting seats 234 are arranged on the bottom plate 21, the lead screw 233 is driven to rotate by the motor 232, so that the guide slide 235 moves along the lead screw 233, and then the guide slide 235 drives the guide slide 222 to move along the linear guide 2312, so as to adjust the position of the object carrier 22 on the bottom plate 21. In the embodiment, the motor 232 is a forward and reverse motor, and the guide slide 235 is a nut seat.

[0044] Please refer to Figure 4 and Figure 8 As shown in the figure, the clamping device 24 is arranged at the lower part of the object carrier plate 221 of the object carrier 22 to position the pipette tip carrier 202 and prevent the pipette tip carrier 202 from shaking. Specifically, the clamping device 24 comprises two groups of guide rails 241, sliding mechanisms 242 arranged on each group of guide rails 241 and capable of relatively moving along the guide rails 241, and adjusting mechanisms 243 for driving the two groups of sliding mechanisms 242 to relatively move along the guide rails 241. Each group of guide rails 241 is arranged in parallel with each other, and the two groups of guide rails 241 are oppositely arranged at the lower part of the object carrier plate 221.

[0045] Each group of sliding mechanisms 242 comprises a connecting plate 2421, guide slides 2422 arranged at both ends of the connecting plate 2421, guide columns 2423 arranged inside each guide slide 2422, and a guide sleeve 2424 and a mounting seat 2425 formed in the middle of the connecting plate 2421. Each guide slide 2422 is provided with a guide groove, and the guide groove is correspondingly provided with a guide rail 241, and the guide slide 2422 can slide along the guide rail 241. Each guide column 2423 passes through the guide hole at the four corners of the second accommodating groove correspondingly, and the working surface of each guide column 2423 is correspondingly formed with a positioning protrusion 2426. The guide sleeve 2424 and the mounting seat 2425 in the middle of the connecting plate 2421 are used to connect the adjusting mechanism 243.

[0046] The inner circumferential surface of one of the guide sleeves 2424 in the two groups of sliding mechanisms 242 is provided with a positive screw thread, and the inner circumferential surface of the other guide sleeve 2424 is provided with a reverse screw thread, so as to drive the two groups of sliding mechanisms 242 to relatively move along the guide rails 241 by the adjusting mechanism 243, and the positioning protrusions 2426 on the two groups of guide columns 2423 are used to position or release the pipette tip carrier 202.

[0047] The adjusting mechanism 243 includes a rotating rod 2431 and a rocker 2432 that drives the rotating rod 2431 to rotate. The rotating rod 2431 passes through the guide sleeve 2424 and the mounting seat 2425 of each set of sliding mechanisms 242, and the rotating rod 2431 can rotate relative to the mounting seat 2425 and the guide sleeve 2424. The rotating rod 2431 is provided with a positive thread and a reverse thread at the position corresponding to the two guide sleeves 2424. The outer periphery of the rotating rod 2431 at the positive thread position is provided with a guide sleeve 2424 with a reverse screw buckle on the inner periphery. The outer periphery of the rotating rod 2431 at the reverse thread position is provided with a guide sleeve 2424 with a positive screw buckle on the inner periphery. One end of the rotating rod 2431 is connected to a rocker 2432, which passes through the movable hole 2211 on the loading plate 221 and is placed on the upper part of the loading plate 221. A gripping portion 2433 is provided at the end of the rocker 2432 to drive the rotating rod 2431 to rotate by swinging the rocker 2432, so that the guide sleeves 2424 in the two sets of sliding mechanisms 242 move relative to each other on the rotating rod 2431, thereby driving the guide sliders 2422 at both ends of each connecting plate 2421 to move relative to each other along the guide rail 241, and the positioning protrusions 2426 of the guide columns 2423 on the two sets of connecting plates 2421 position or release the pipette tip carrier 202.

[0048] Please refer to the Figures 4 to 7 As shown, the beam mechanism 30 is installed on the work platform 20 to carry the operating body 40 and drive the operating body 40 to move along the beam mechanism 30. The beam mechanism 30 includes two support arms 31 and a beam body 32 arranged on the two support arms 31. The two support arms 31 are correspondingly connected to the two ends of the bottom plate 21 of the work platform 20. The beam body 32 includes a beam 323, beam guide rails 321 arranged in parallel at the upper and lower ends of a circumference of the beam 323, a beam screw assembly 322 placed between the two beam guide rails 321, a drive motor 324, a support plate 325 arranged on the other circumference of the beam 323, and a tank chain 326 arranged on the support plate 325 and retractable along the support plate 325.

[0049] The crossbeam guide rail 321 is cooperatively connected with the operating body 40 so that the operating body 40 can slide back and forth on the crossbeam guide rail 321 .

[0050] The crossbeam screw rod assembly 322 comprises two support bases 3221 and a crossbeam screw rod 3222 arranged between the two support bases 3221 and rotatable relative to the support bases 3221, the two support bases 3221 are installed at the two ends of the crossbeam 323 between the two crossbeam guide rails 321, the support base 3221 comprises a strip-shaped plate and seat bodies formed at the two ends of the strip-shaped plate, the seat bodies of the support base 3221 are correspondingly provided with through holes for the crossbeam screw rod 3222 to pass through and rotate in the through holes, the crossbeam screw rod 3222 is connected with the operation main body 40, one end of the crossbeam screw rod 3222 is connected with the rotating shaft of the driving motor 324, the driving motor 324 drives the crossbeam screw rod 3222 to rotate on the two seat bodies of the support base 3221, thereby enabling the operation main body 40 to slide back and forth along the crossbeam guide rail 321.

[0051] The operation main body 40 comprises a main body plate 41, a sliding assembly arranged on one side of the main body plate 41, a cap rotating device 50 and a liquid pumping device 60 arranged on the other side of the main body plate 41, and a machine cover 43 arranged on the outer periphery of the cap rotating device 50 and the liquid pumping device 60, the main body plate 41 is provided with a connecting piece 411 connected with one end of the tank chain 326 on the other peripheral surface of the crossbeam 323, the sliding assembly comprises two crossbeam sliding blocks 42 and a crossbeam sliding sleeve (not shown in the figure) arranged between the two crossbeam sliding blocks 42, each crossbeam sliding block 42 is matched with a crossbeam guide rail 321, the crossbeam sliding sleeve is arranged on the crossbeam screw rod 3222 of the crossbeam screw rod assembly 322, and the inner peripheral surface of the crossbeam sliding sleeve is provided with a screw thread engaged with the crossbeam screw rod 3222, the driving motor 324 drives the crossbeam screw rod 3222 to rotate, so that the crossbeam sliding sleeve of the sliding assembly moves back and forth along the crossbeam screw rod 3222, and drives the two crossbeam sliding blocks 42 to slide along the crossbeam guide rail 321, and in addition, drives the tank chain 326 on the other peripheral surface of the crossbeam 323 to contract and move along the supporting plate 325.

[0052] The main body plate 41 is provided with a fixing structure 412 for installing the cap rotating device 50 and the liquid pumping device 60, the fixing structure 412 comprises a plate body 4121 and a rib plate 4122 for supporting the plate body 4121, the cap rotating device 50 comprises a main driver 51, a lifting mechanism 52, a cap rotating mechanism 53 and a cap tray mechanism 54.

[0053] Please refer to Figures 9 to 11 The main driver 51 is installed on the plate body 4121 and drives the lifting mechanism 52 to slide up and down along the main body plate 41, the main driver 51 comprises a main motor 511 and a driving screw rod 512 connected with the main shaft of the main motor 511, the driving screw rod 512 is connected with the lifting mechanism 52, the main motor 511 is a reversible motor, which drives the driving screw rod 512 to rotate through the main motor 511, drives the lifting mechanism 52 to quickly slide up and down along the main body plate 41, so that the cap rotating mechanism 53 is quickly positioned or homed.

[0054] The lifting mechanism 52 comprises two rails installed on the main plate 41 in vertical structure and parallel to each other, a lifting assembly 521 arranged on the rails, and a driving device 522 for driving the lifting assembly 521 to slide along the rails. The lifting assembly 521 comprises a lifting plate 5211, a push plate 5212 arranged on the lifting plate 5211, and a connecting plate 5213. The lifting plate 5211 is slidably installed on the two rails. The push plate 5212 is connected with the driving screw 512. The connecting plate 5213 is provided with a through hole for the driving screw 512 to pass through and be connected with the push plate 5212. The driving screw 512 is rotated to drive the push plate 5212 to move, so that the lifting mechanism 52 is lifted and slides, and the cap is removed after the cap of the sampling tube 2011 is screwed by the cap screwing mechanism 53.

[0055] The driving device 522 comprises a driven motor and a driven screw connected to the rotating shaft of the driven motor. The driven motor is arranged on the connecting plate 5213. The lifting plate 5211 is provided with a driven driving block. The driven driving block is connected with the driven screw of the driving device 522. The driven motor is a reversible motor and drives the driven screw to rotate, so as to drive the driven driving block to move, and further drive the lifting plate 5211 and the cap screwing mechanism 53 to slowly slide, so as to automatically open or screw the caps of the sampling tubes 2011 at the same time.

[0056] The cap screwing mechanism 53 is connected to the lifting plate 5211 of the lifting mechanism 52, and is used for automatically opening or screwing the caps of the plurality of sampling tubes 2011 arranged in the sampling tube carrier 201 at the same time. Specifically, the cap screwing mechanism 53 comprises a cap screwing driver 531, a gear box assembly 532 matched with the cap screwing driver 531, a cap screwing mounting box 533 arranged at the lower part of the gear box assembly 532, a cap screwing chuck assembly 534 arranged in the cap screwing mounting box 533, and an unloading cap rod 535 arranged in the cap screwing chuck assembly 534.

[0057] Please refer to Figure 12 As shown in the figure, the gear box assembly 532 comprises a gear box body 5321 and a plurality of sets of gear assemblies 5322 arranged uniformly and meshed with each other in the gear box body 5321. The gear box body 5321 is installed on the lifting plate 5211. Each set of gear assemblies 5322 comprises a driving gear 5323 and a driven gear 5324 meshed with the driving gear 5323. The driven gear 5324 of one of the gear assemblies 5322 of each adjacent two sets of gear assemblies is meshed with the driving gear 5323 of the other gear assembly 5322. In the embodiment, there are six sets of gear assemblies 5322 arranged uniformly in two rows in the gear box body 5321, so as to automatically open or screw the caps of the six sampling tubes 2011 at the same time.

[0058] The cap driving device 531 is arranged on the gear box 5321 to drive the gear assembly 5322 to rotate, and the cap driving device 531 comprises a cap motor and a driving gear 5312 arranged on the main shaft of the cap motor. The body of the cap motor is arranged outside the gear box 5321, the main shaft of the cap motor penetrates into the inside of the gear box 5321 and is connected with the driving gear 5312. The driving gear 5312 is engaged with two driven gears 5324 in the two groups of gear assemblies 5322 at the end. The cap motor is a forward and reverse motor, and the driving gear 5312 is driven to rotate by the cap motor, so that the driving gears 5323 in the six groups of gear assemblies 5322 rotate clockwise or counterclockwise in the same direction.

[0059] The cap mounting box 533 is connected to the lifting plate 5211 and arranged below the gear box assembly 532 in the gear box 5321 to mount the cap chuck assembly 534. The cap chuck assembly 534 is six groups, and each group of cap chuck assembly 534 is matched with the driving gear 5323 in the gear assembly 5322. Specifically, each group of cap chuck assembly 534 comprises a cap chuck and a rod arranged on the cap chuck. The rod penetrates through the bottom wall of the cap mounting box 533 and is connected to the center of the driving gear 5323. The cap chuck is used to open or cap the cap of the sampling tube 2011. The driving gears 5323 in the six groups of gear assemblies 5322 rotate in the same direction, thereby driving the six groups of cap chuck assemblies 534 to rotate clockwise or counterclockwise in the same direction. The lifting plate 5211 and the cap mechanism 53 are driven by the driver 522 to slide, so that the cap mechanism 53 automatically opens or caps the caps of the six sampling tubes 2011 at the same time. In the embodiment, counterclockwise is to open the cap, and clockwise is to cap the cap. The cap unloading rod 535 is six, and each cap unloading rod 535 is arranged in the cap chuck of the cap chuck assembly 534 and penetrates through the cap mounting box 533 and the gear box assembly 532. After the one end of the cap unloading rod 535 is pushed by the push plate 5212 of the lifting mechanism 52, the cap unloading rod 535 moves along the cap chuck assembly 534. The other end of the cap unloading rod 535 is pushed after the cap mechanism 53 caps the cap of the sampling tube 2011, so that the cap is unloaded along the cap chuck.

[0060] Please refer to Figure 11As shown, the cap tray mechanism 54 is installed at the lower part of the main plate 41, and is used to prevent the cap from falling into other sample tubes and causing cross infection after the cap of the sample tube 2011 is opened by the cap rotating mechanism 53. The cap tray mechanism 54 comprises a tray box 541, a tray driving mechanism 542 arranged in the tray box 541, and a cap tray 543 connected with the tray driving mechanism 542. The tray box 541 is installed at the lower part of the main plate 41, and a through slot is formed at one end of the tray box 541 for the cap tray 543 to pass through. The tray driving mechanism 542 comprises a first motor 5421, a first lead screw 5422 connected with the rotating shaft of the first motor 5421, and a first driving assembly matched with the first lead screw 5422. The first motor 5421 is arranged on the tray box 541 and opposite to the through slot. The first driving assembly comprises two parallel first guide rails 5423 arranged in the tray box 541, and a first sliding block 5424 matched and connected with the two first guide rails 5423. The first sliding block 5424 is matched and connected with the first lead screw 5422, and two first sliding protrusions are formed on the first sliding block 5424. The first sliding protrusions are provided with sliding grooves matched with the first guide rails 5423. The cap tray 543 is connected with the lower end of the first sliding block 5424. The first motor 5421 is a reversible motor, which drives the first lead screw 5422 to rotate, drives the first sliding block 5424 to slide along the first guide rails 5423, and then drives the cap tray 543 to extend and retract, and passes through the through slot at one end of the tray box 541, so that the cap tray 543 is placed at the lower part of the cap rotating mechanism 53, and prevents the cap from falling into other sample tubes and causing cross infection after the cap of the sample tube 2011 is opened by the cap rotating mechanism 53.

[0061] Please refer to Figures 9 to 11 As shown, the liquid pumping device 60 is arranged on the main plate 41, and is used to pump the to-be-tested liquid along the sample tube 2011 after the cap of the sample tube 2011 is opened by the cap rotating device 50, and spray the to-be-tested liquid into the nucleic acid extraction reagent plate 203. The liquid pumping device 60 comprises a first driver 61, a liquid pumping lifting mechanism 62 matched and connected with the first driver 61, a liquid pumping mechanism 63 arranged on the liquid pumping lifting mechanism 62, a liquid drop prevention tray mechanism 64 arranged at the lower part of the main plate 41, and a telescopic mechanism 65 arranged at the side of the liquid pumping mechanism 63 and used to drive the liquid pumping mechanism 63 to extend and retract.

[0062] Please refer to Figure 10As shown, the motor of the first driver 61 is mounted on the plate body 4121, one end of the lead screw of the first driver 61 is connected with the rotating shaft of the motor, and the other end is connected with the liquid pumping lifting mechanism 62, the liquid pumping lifting mechanism 62 includes two slides 621 vertically arranged on the main plate 41, a liquid pumping lifting plate 622 slidably arranged on the two slides 621, and a liquid pumping connecting plate 623 arranged on the liquid pumping lifting plate 622, the lead screw of the first driver 61 is connected with the liquid pumping connecting plate 623, and the liquid pumping connecting plate 623 drives the liquid pumping lifting plate 622 to slide up and down along the two slides 621 on the main plate 41 by rotating the lead screw driven by the forward and reverse motor in the first driver 61, so that the liquid pumping mechanism 63 is quickly positioned or homed.

[0063] Please refer to Figure 9 As shown, the liquid pumping mechanism 63 is used to clamp the unused disposable pipette tip 2021 built in the pipette tip carrier 202, and make the pipette tip 2021 suck the liquid to be tested along the sampling tube 2011 with the cap opened by the cap opening device 50, spray the liquid to be tested in the pipette tip 2021 into the nucleic acid extraction reagent plate 203, and then drop the used pipette tip 2021 into another pipette tip carrier 202, the liquid pumping mechanism 63 includes a liquid pumping driver 631, a liquid pumping sliding assembly 632 connected with the liquid pumping driver 631, and a liquid pumping device 633 connected with the liquid pumping sliding assembly 632.

[0064] The liquid pumping driver 631 includes a liquid pumping motor capable of forward and reverse rotation, and a transmission lead screw connected with the rotating shaft of the liquid pumping motor, the liquid pumping motor is arranged on the liquid pumping connecting plate 623, and the rotating shaft of the liquid pumping motor passes through the liquid pumping connecting plate 623 and is connected with the transmission lead screw of the liquid pumping driver 631; the liquid pumping sliding assembly 632 is connected with the transmission lead screw of the liquid pumping driver 631, and the liquid pumping sliding assembly 632 is driven by the liquid pumping driver 631 to slide along the track installed on the liquid pumping lifting plate 622, the liquid pumping sliding assembly 632 includes a liquid pumping slide plate and a driving block arranged on the liquid pumping slide plate, the liquid pumping slide plate is slidably connected with the track on the liquid pumping lifting plate 622, and the driving block is connected with the transmission lead screw of the liquid pumping driver 631, so that the transmission lead screw is driven to rotate by the liquid pumping driver 631, and then the driving block drives the liquid pumping slide plate to slide along the track on the liquid pumping lifting plate 622, so that the liquid pumping device 633 completes the process of pumping or spraying liquid, when the liquid pumping motor rotates forward, the liquid pumping sliding assembly 632 slides upward along the track on the liquid pumping lifting plate 622, and the liquid pumping device 633 sucks liquid, when the liquid pumping motor reverses, the liquid pumping sliding assembly 632 slides downward along the track on the liquid pumping lifting plate 622, and the liquid pumping device 633 sprays liquid.

[0065] The liquid pumping device 633 is connected to the pumping slide plate of the pumping slide assembly 632, and the liquid pumping device 633 comprises a frame body 6331, a falling plate 63311 arranged at the lower part of the frame body 6331, two light shafts 6332 arranged at the upper end of the frame body, upper piston members 6333 arranged on the two light shafts 6332 correspondingly, lower piston members 6334 arranged at the lower end of the frame body, support rods 6330 arranged at the four corners between the upper piston members 6333 and the lower piston members 6334 correspondingly, and a plurality of piston rods 6335 arranged between the upper piston members 6333 and the lower piston members 6334 correspondingly.

[0066] The upper piston members 6333 comprise upper piston sliding blocks 6336 arranged at both ends of the light shafts 6332 and capable of relatively sliding along the light shafts 6332, and an upper piston mounting plate 6337 arranged on the frame body and located between the two upper piston sliding blocks 6336, and the lower piston members 6334 comprise lower piston sliding blocks 6338 arranged at both sides of the lower end of the frame body and capable of relatively moving, and a lower piston mounting plate 6339 arranged at the lower end of the frame body and located between the two lower piston sliding blocks 6338.

[0067] The four support rods 6330 are correspondingly connected at the four corners of the two upper piston sliders 6336 and the two lower piston sliders 6338, so that the two upper piston sliders 6336 and the two lower piston sliders 6338 simultaneously extend and retract. The one ends of the piston rods 6335 are correspondingly arranged on the two upper piston sliders 6336 and the upper piston mounting plate 6337 of the upper piston piece 6333, the one ends of the piston rods 6335 correspondingly pass through the two lower piston sliders 6338 and the lower piston mounting plate 6339 of the lower piston piece 6334, and the lower piston sliders 6338 and the lower piston mounting plate 6339 correspondingly pass through the end face parts of the piston rods 6335 to form a ring of pipe body clamping grooves. Each pipe body clamping groove cooperates with a piston rod 6335 to clamp the pipette tip 2021 and draw liquid in the sample tube 2011. In the embodiment, there are six piston rods 6335, which are evenly arranged in front and back two rows between the upper piston piece 6333 and the lower piston piece 6334, so as to simultaneously draw liquid in the six sample tubes 2011. The lower material falling plate 63311 of the frame body 6331 is provided with two rows of material holes corresponding to the piston rods 6335. Each material falling plate 63311 is provided with a material hole. The material holes on the two sides of the material falling plate 63311 are strip-shaped holes, and the material hole in the middle is a circular hole, so that the pipette tip 2021 can move along the corresponding strip-shaped hole on the material falling plate 63311, thereby adjusting the distance between the pipette tips 2021. Specifically, when the pipe body clamping groove cooperates with the piston rod 6335 to clamp the pipette tip 2021 with a liquid passing hole at the front end of the pipe body from the pipette tip carrier 202, the pipette tip 2021 enters the liquid in the sample tube 2011. When the liquid drawing motor rotates forward, the liquid drawing sliding assembly 632 slides upward along the rail of the liquid drawing lifting plate 622, the piston rods 6335 in the liquid drawing device 633 move upward and generate upward suction force, so as to draw the liquid in the sample tube 2011 into the pipette tip 2021. When the liquid drawing motor reverses, the liquid drawing sliding assembly 632 slides downward along the rail of the liquid drawing lifting plate 622, the piston rods 6335 in the liquid drawing device 633 move downward and generate downward thrust, so as to spray the liquid in the sample tube 2011 into the nucleic acid extraction reagent plate 203. When the liquid drawing motor rotates forward again, the liquid drawing sliding assembly 632 slides upward along the rail of the liquid drawing lifting plate 622, the piston rods 6335 in the liquid drawing device 633 move upward, so that the piston rods 6335 and the pipette tip 2021 pipe wall are separated, and the pipette tip 2021 falls into another pipette tip carrier 202 along the material falling plate 63311.

[0068] Please refer to Figure 11As shown, the drip-proof tray mechanism 64 is installed at the lower part of the main body plate 41, and is used to prevent the liquid at the end of the pipette tip 2021 from falling into other sample tubes or nucleic acid extraction reagent plates and causing cross infection after the liquid suction device 633 of the liquid suction mechanism 60 sucks the liquid. The drip-proof tray mechanism 64 comprises a main box body 641, a drip-proof tray driving mechanism 642 arranged in the main box body 641, and a drip-proof tray 643 connected with the drip-proof tray driving mechanism 642. The main box body 641 is installed at the lower part of the main body plate 41, and a notch is formed at one end of the main box body 641 to allow the drip-proof tray 643 to pass through. The drip-proof tray driving mechanism 642 comprises a second motor 6421, a second lead screw 6422 connected with the rotating shaft of the second motor 6421, and a second driving assembly matched with the second lead screw 6422. The second motor 6421 is arranged at the opposite end of the main box body 641 with the notch. The second driving assembly comprises two parallel second guide rails 6423 arranged in the main box body 641, and a second sliding block 6424 matched and connected with the two second guide rails 6423. The second sliding block 6424 is matched and connected with the second lead screw 6422. Two second sliding protrusions are formed on the second sliding block 6424, and sliding grooves matched with the second guide rails 6423 are arranged on the second sliding protrusions. The drip-proof tray 643 is connected with the lower end of the second sliding block 6424. The second motor 6421 is a reversible motor, which drives the second lead screw 6422 to rotate through the second motor 6421, drives the second sliding block 6424 to slide along the second guide rail 6423, drives the drip-proof tray 643 to extend and retract, and passes through the notch at one end of the main box body 641, so that the drip-proof tray 643 is placed at the lower part of the liquid suction mechanism 63. After the liquid suction device 633 of the liquid suction mechanism 63 sucks the liquid, the drip-proof tray 643 prevents the liquid from falling into other sample tubes or reagent boxes and causing cross infection.

[0069] Please refer to Figure 10 As shown, the telescopic mechanism 65 is arranged at the lower end side of the frame 6331 of the liquid suction mechanism 63, and drives the piston rods 6335 on both sides of the liquid suction mechanism 63 to relatively extend and retract, so as to adjust the distance between the clamped pipette tips 2021, accurately clamp the pipette tips 2021, suck liquid through the pipette tips 2021, spray liquid into the nucleic acid extraction reagent plate 203, and drop liquid from the pipette tips 2021. Specifically, the telescopic mechanism 65 comprises a telescopic driving motor 651 and a positive and negative toothed lead screw 652 connected with the rotating shaft of the telescopic driving motor 651. The telescopic driving motor 651 is installed at the lower end side of the frame 6331. The rotating shaft of the telescopic driving motor 651 passes through the frame 6331 and is connected with the positive and negative toothed lead screw 652. Two lower piston sliding blocks 6338 are matched and connected with the positive and negative toothed lead screw 652. The telescopic driving motor 651 drives the positive and negative toothed lead screw 652 to rotate, so that the two lower piston sliding blocks 6338 move relatively along the positive and negative toothed lead screw 652, and then drive the piston rods 6335 on both sides to relatively extend and retract with respect to the piston rod 6335 in the middle.

[0070] In operation, a plurality of sample tubes 2011 containing the test liquid to be detected are placed in the sample tube carrier 201, a plurality of unused disposable pipette tips 2021 are placed in one of the pipette tip carriers 202, another disposable pipette tip 2021 to be used is placed in another pipette tip carrier 202, and a plurality of nucleic acid extraction reagent plates 203 are placed on the carrier 22 of the stage 20 of the execution module 200, and the stage 20 of the execution module 200 and the operation body 40 are controlled by the control module 100 to adjust the position of the carrier 22 to correspond to the operation body 40.

[0071] The operation body 40 slides along the beam mechanism 30, the first driver 61 of the liquid suction device 60 drives the liquid suction lifting mechanism 62 to drive the liquid suction mechanism 63 to slide downward, the liquid suction mechanism 63 holds the corresponding six unused disposable pipette tips 2021 in one of the pipette tip carriers 202, the first driver 61 drives the liquid suction lifting mechanism 62 to drive the liquid suction mechanism 63 to slide upward to a preset position, the sliding assembly 42 of the operation body 40 slides along the beam body 32 of the beam mechanism 30, so that the cap screwing mechanism 53 of the cap screwing device 50 is opposite to the plurality of sample tubes 2011 in the sample tube carrier 201, the lifting mechanism 52 drives the cap screwing mechanism 53 to move downward, the cap screwing chuck of the six cap screwing chuck assemblies 534 is simultaneously inserted into the corresponding cap of the sample tube 2011, the cap screwing driver 531 drives the six cap screwing chuck assemblies 534 to rotate in the counterclockwise direction, and the lifting plate 5211 and the cap screwing mechanism 53 are driven by the driver 522 to slide upward, thereby automatically opening the caps of the six sample tubes 2011, the cap tray 543 of the cap tray mechanism 54 passes through the through slot at one end of the tray box body 541 and moves to the lower part of the cap screwing mechanism 53, thereby preventing the caps from falling into other sample tubes and causing cross infection;

[0072] The sliding assembly 42 of the operation body 40 slides along the beam body 32, so that the six disposable pipette tips 2021 held by the liquid suction mechanism 63 of the liquid suction device 60 are opposite to the opened caps of the sample tubes 2011, the liquid suction lifting mechanism 62 drives the liquid suction mechanism 63 to slide downward, the pipette tip 2021 is inserted into the corresponding sample tube 2011, and the pipette tip 2021 completes the liquid suction process in the sample tube 2011 by the liquid suction device 633, the liquid suction lifting mechanism 62 drives the liquid suction mechanism 63 to slide upward, the anti-dripping tray 643 of the anti-dripping tray mechanism 64 passes through the slot at one end of the main box body 641 and moves to the lower part of the liquid suction mechanism 63, thereby preventing the liquid in the pipette tip 2021 from falling into other sample tubes and causing cross infection;

[0073] The sliding assembly 42 of the operation body 40 slides along the beam body 32, so that the cap screwing mechanism 53 of the cap screwing device 50 corresponds to the open caps of the sample tubes 2011 in the sample tube carrier 201. The cap tray 543 of the cap tray mechanism 54 moves into the tray box 541 through the slot at one end of the tray box 541 and is restored to the original state. The lifting mechanism 52 drives the cap screwing mechanism 53 to move downward. The cap screwing chuck assemblies 534 of the six groups of cap screwing chuck assemblies 534 are simultaneously placed in the corresponding cap of the sample tube 2011. The cap screwing driver 531 drives the six groups of cap screwing chuck assemblies 534 to rotate in the clockwise direction, simultaneously seals the caps of the six sample tubes 2011, and pushes the unloading rod 535 through the push plate 5212 to correspondingly unload the caps from the cap screwing chuck.

[0074] The sliding assembly 42 of the operation body 40 slides along the beam body 32, so that the cap screwing mechanism 53 of the cap screwing device 50 corresponds to the open caps of the sample tubes 2011 in the sample tube carrier 201. The cap tray 543 of the cap tray mechanism 54 moves into the tray box 541 through the slot at one end of the tray box 541 and is restored to the original state. The lifting mechanism 52 drives the cap screwing mechanism 53 to move downward. The cap screwing chuck assemblies 534 of the six groups of cap screwing chuck assemblies 534 are simultaneously placed in the corresponding cap of the sample tube 2011. The cap screwing driver 531 drives the six groups of cap screwing chuck assemblies 534 to rotate in the clockwise direction, simultaneously seals the caps of the six sample tubes 2011, and pushes the unloading rod 535 through the push plate 5212 to correspondingly unload the caps from the cap screwing chuck.

[0075] The liquid suction lifting mechanism 62 drives the liquid suction mechanism 63 to slide upward, the sliding assembly 42 of the operation main body 40 slides along the cross beam main body 32, the drip-proof tray 643 of the drip-proof tray mechanism 64 passes through the slot at one end of the main box body 641, moves to the lower part of the liquid suction mechanism 63, prevents the liquid in the nozzle of the pipette tip 2021 from falling into other nucleic acid extraction reagent plates 203 to cause cross infection, adjusts the position of the carrier 22, the telescopic mechanism 65 drives the piston rods 6335 on both sides of the liquid suction mechanism 63 to extend and retract relatively, so as to adjust the distance between the clamped pipette tips 2021, so that each pipette tip 2021 is placed above another pipette tip carrier 202, the drip-proof tray 643 of the drip-proof tray mechanism 64 moves into the main box body 641 along the slot of the main box body 641, the liquid suction lifting mechanism 62 drives the liquid suction mechanism 63 to slide downward, the pipette tip 2021 is placed into the corresponding pipette tip carrier 202, the piston rod 6335 in the liquid suction device 633 moves upward, so that the piston rod 6335 is separated from the wall of the pipette tip 2021, the pipette tip 2021 falls into the pipette tip carrier 202 along the falling plate 63311, so as to complete a full-automatic sampling process of the sample liquid. By controlling the carrier 20 and the operation main body 40 by the control module, the sample liquid can be collected cyclically.

[0076] In summary, the system of the full-automatic sampling tube cap screwing and pipetting workstation of the application adjusts the position of the carrier 22 in the carrier 20 to correspond to the operation main body 40 by the control module, drives the operation main body 40 to slide along the cross beam mechanism 30, so as to realize automatic operation, and the cap screwing device 50 and the liquid suction device 60 work cooperatively and simultaneously sample the sample liquid in multiple sampling tubes, improve work efficiency, and reduce labor intensity.

[0077] The above-described embodiments are only preferred embodiments of the application and do not limit the scope of the application. Without departing from the design spirit of the application, various modifications and improvements of the technical solutions of the application made by those skilled in the art shall fall within the protection scope of the claims of the application.

Claims

1. A fully automatic sampling tube capping and pipetting workstation system, characterized by: The invention comprises an execution module (200) and a control module (100) for controlling the execution module (200), wherein the execution module (200) comprises a stage (20), a beam mechanism (30) mounted on the stage (20), and an operating body (40) disposed on the beam mechanism (30) and capable of sliding along the beam mechanism (30), wherein the control module (100) controls the positions of the stage (20) and the operating body (40) in the execution module (200) to correspond to each other, so that the operating body (40) can sample sample liquids in a plurality of sampling tubes on the stage (20) and place the sampled liquids into a nucleic acid extraction reagent plate. The operating body (40) includes a capping device (50) and a liquid pumping device (60), wherein the capping device (50) includes a main driver (51) mounted on a main body plate (41) of the operating body (40), a lifting mechanism (52) driven by the main driver (51) to slide along the main body plate (41), a capping mechanism (53) connected to the lifting mechanism (52), and a cap tray mechanism (54) mounted at the lower portion of the main body plate (41), and the liquid pumping device (60) includes a first driver (61) mounted on the main body plate (41), a liquid pumping lifting mechanism (62) connected to the first driver (61), a liquid pumping mechanism (63) mounted on the liquid pumping lifting mechanism (62), an anti-drip tray mechanism (64) mounted at the lower portion of the main body plate (41), and a telescopic mechanism (65) mounted on the side of the liquid pumping mechanism (63) to drive the liquid pumping mechanism (63) to telescope. The lifting mechanism (52) includes a track, a lifting assembly (521) arranged on the track, and a slave driver (522) for driving the lifting assembly (521) to slide along the track. The track is two and is vertically structured and parallel to each other and is installed on the main body plate (41). The lifting assembly (521) includes a lifting plate (5211), a push plate (5212) arranged on the lifting plate (5211), and a connecting plate (5213). The lifting plate (5211) is slidably installed on the two tracks. The push plate (5212) is connected to the driving screw (512). The connecting plate (5213) is provided with a through hole for the driving screw (512) to pass through and then connect to the push plate (5212). The motor of the first driver (61) is mounted on the main body plate (41), one end of the lead screw of the first driver (61) is connected to the motor shaft, and the other end of the lead screw of the first driver (61) is cooperatively connected to the liquid pumping lifting mechanism (62). The liquid pumping lifting mechanism (62) includes two slideways (621) vertically arranged on the main body plate (41), a liquid pumping lifting plate (622) slidably arranged on the two slideways (621), and a liquid pumping connecting plate (623) arranged on the liquid pumping lifting plate (622). The lead screw of the first driver (61) is cooperatively connected to the liquid pumping connecting plate (623).

2. The system of the fully automatic sampling tube capping and liquid transfer workstation according to claim 1, characterized in that: The slave driver (522) includes a slave motor and a slave screw connected to the shaft of the slave motor. The slave motor is arranged on the connecting plate (5213). The lifting plate (5211) is provided with a slave drive block. The slave drive block is connected to the slave screw of the slave driver (522). The slave motor drives the slave screw to rotate to drive the slave drive block to move, thereby driving the lifting plate (5211) and the capping mechanism (53) to slide, so as to cooperate with a plurality of capping chuck assemblies (534) on the capping mechanism (53) to automatically open or cap the caps of the sampling tubes at the same time.

3. The system of the fully automatic sampling tube capping and liquid transfer workstation according to claim 1, characterized in that: The liquid pumping mechanism (63) includes a liquid pumping driver (631), a liquid pumping sliding assembly (632) connected to the liquid pumping driver (631), and a liquid pumping device (633) connected to the liquid pumping sliding assembly (632). The telescopic mechanism (65) is arranged on the lower side of the frame (6331) of the liquid pumping mechanism (63) to drive the liquid pumping device (633) to retract relatively.

4. The system of the fully automatic sampling tube capping and liquid transfer workstation according to claim 1, characterized in that: The crossbeam mechanism (30) includes support arms (31) connected to both ends of the loading platform (20) and a crossbeam body (32) arranged on the two support arms (31). The operating body (40) also includes the main body plate (41) and a sliding component arranged on one side of the main body plate (41). The sliding component of the operating body (40) is cooperatively connected to the crossbeam body (32) so that the operating body (40) can be controlled by the control module (100) to slide along the crossbeam body (32).

5. The system of the fully automatic sampling tube capping and liquid transfer workstation according to claim 1, characterized in that: The sample carrier (20) includes a base plate (21), a sample carrier (22) disposed on the base plate (21) and movable along the base plate (21), and a driving mechanism (23) for driving the sample carrier (22) to move along the base plate (21). The sample carrier (22) is used to carry an instrument for sampling liquid, and the driving mechanism (23) is controlled by a control module (100) to drive the sample carrier (22) to slide along the base plate (21).

6. A method for operating a system of a fully automatic sampling tube capping and liquid transfer workstation according to any one of claims 1 to 5, characterized in that: The following steps are involved: S1. The apparatus for sampling the liquid is placed on the carrier of the stage (20) in a corresponding manner, and the control module (100) controls the stage (20) and the operating body (40) of the execution module (200) to operate, and adjusts the positions of the carrier (22) and the operating body (40) to correspond to each other; S2. The control module (100) controls the operating body (40) of the execution module (200) to slide along the crossbeam mechanism (30) to the top of the pipette tip carrier, and controls the liquid extraction mechanism (63) of the liquid extraction device (60) to pick up a plurality of pipette tips from the carrier (22) and slide them to a preset position; S3. The control module (100) controls the operating body (40) of the execution module (200) to slide along the crossbeam mechanism (30) to the top of the sampling tube carrier, and controls the capping mechanism (53) of the capping device (50) to open the caps of several sampling tubes at the same time, and the cap tray mechanism (54) moves to the bottom of the capping mechanism (53); S4. The control module (100) controls the operating body (40) of the execution module (200) to slide along the crossbeam mechanism (30) to the top of the pipette tip carrier, and controls the pipette tip held by the extraction mechanism (63) of the extraction device (60) to slide upward to a preset position after completing extraction in the sampling tube, and the anti-drip tray mechanism (64) moves to the bottom of the extraction mechanism (63); S5. The control module (100) controls the operating body (40) of the execution module (200) to slide along the crossbeam mechanism (30) to the top of the sampling tube carrier, and controls the cap tray mechanism (54) of the capping device (50) to return to its original position, and the capping mechanism (53) simultaneously caps the caps of several sampling tubes; S6. The control module (100) controls the operating body (40) of the execution module (200) to slide along the crossbeam mechanism (30) to above the pipette tip carrier, and controls the telescopic mechanism (65) of the liquid extraction device (60) to drive the pipette tips clamped by the liquid extraction mechanism (63) to relatively telescope, and adjust the spacing between the clamped pipette tips so that each pipette tip corresponds to a cavity of the nucleic acid extraction reagent plate one by one; S7. The control module (100) controls the anti-drip tray mechanism (64) of the liquid extraction device (60) to return to its original position, and controls the liquid extraction mechanism (63) to drive the liquid in the pipette tip to be ejected into the chamber of the reagent chamber; S8. The control module (100) controls the anti-drip tray mechanism (64) to move to the lower part of the liquid extraction mechanism (63), and the telescopic mechanism (65) drives the pipette tips clamped by the liquid extraction mechanism (63) to move relative to each other, adjusts the distance between the pipette tips, so that each pipette tip corresponds to another pipette tip carrier, and the anti-drip tray mechanism (64) returns to its original position, and the liquid extraction mechanism (63) drives the pipette tips to fall into the pipette tip carrier, thereby completing a fully automated sampling process of the sample liquid.

7. The method for operating the fully automatic sampling tube capping and liquid transfer workstation according to claim 6, characterized in that: The apparatus used for sampling the test liquid in S1 includes a sampling tube carrier rack equipped with several sampling tubes, two pipette tip carrier racks and several nucleic acid extraction reagent plates. Each sampling tube contains the liquid to be tested. One of the pipette tip carrier racks contains several unused pipette tips, and the other pipette tip carrier rack contains used pipette tips. The nucleic acid extraction reagent plates are used to store the liquid to be tested.

Citation Information

Patent Citations

  • Full-automatic biological sample sub-packaging device

    CN113203599A

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    CN216144817U