Image acquisition system for AI-based automatic intelligent pathological section diagnosis

Abstract

The application discloses an image acquisition system for automatic intelligent pathological section diagnosis based on AI, which is characterized in that a base is arranged on the basis of a two-dimensional automatic adjusting device, a longitudinal sliding seat is installed on the base through a guide structure, a longitudinal sliding driving mechanism for controlling the longitudinal sliding of the longitudinal sliding seat relative to the base is arranged, a transverse sliding seat is installed on the longitudinal sliding seat through a guide structure, a transverse sliding driving mechanism for controlling the transverse sliding of the transverse sliding seat relative to the longitudinal sliding seat is arranged, and a locking mechanism for fixing a glass slide is arranged on the transverse sliding seat. The application can realize the short-distance repeated movement of an electronic carrier platform suitable for X-axis and Y-axis without expanding errors, so that it is possible to obtain surrounding multiple collection points through the short-distance repeated movement of the X-axis and Y-axis, the multiple collection points can improve the collection efficiency, and the features of the collection points can be verified with each other to provide accurate position basis for subsequent point collection.

Description

Technical Field

[0001] This invention belongs to the field of pathological slide scanning diagnosis technology, specifically relating to a microscope electronic stage image acquisition system suitable for short-distance multi-point sampling along the X and Y axes. Background Technology

[0002] Patients undergoing pathological examinations at hospitals are particularly prone to tumor screening. However, direct testing often fails to rule out malignancy and a definitive diagnosis cannot be made without microscopic examination of the pathological specimens. This requires a doctor to examine the slides under a microscope for accurate diagnosis. The pathological slide examination for cancer refers to the process of preparing the slides in the pathology department. For example, before diagnosing esophageal cancer, a gastroscopy biopsy is required. During the gastroscopy, a tissue biopsy is taken for pathology. The tissue sample is placed in a vial and sent to the pathology department, where it is prepared into a paraffin block and then sectioned to form a pathological slide. Generally, pathological examination results are obtained relatively late; for example, in cases of severe cervical erosion, slide cancer examination results typically take two weeks. Sometimes, due to a large number of patients, slides may need to be sent to other institutions for pathological examination. Sometimes, doctors also need to issue a slide borrowing slip to view the slides in their original form, further prolonging the diagnostic time. In reality, apart from a few pathological slides that are difficult to diagnose directly and require joint consultation by doctors, most of the microscopic observation characteristics of various pathological specimens on slides are very obvious, and it is easy to make a diagnosis. However, due to the current need for human intervention and procedural limitations, slide tumor samples that should be diagnosed quickly cannot be diagnosed quickly, thus delaying the best treatment time for patients.

[0003] With the continuous development and maturation of artificial intelligence and image acquisition technologies, it has become possible to observe some routine pathological specimen slides that are easy to diagnose quickly based on obvious characteristics by combining image acquisition with artificial intelligence technologies, and to use visual measurement, detection, and diagnosis.

[0004] Currently, in the medical field, when automatically scanning pathological slides with a microscope for diagnostic reference, dynamic support for scanning is required from an electronic stage. Since the microscope needs to magnify the pathological slides by 100 times for sampling, the existing mechanical design of the electronic stage is generally insufficient in precision when applied to extremely small adjustments, resulting in larger errors. This leads to large errors or even erroneous results in the synthesis of acquired images. Therefore, the pathological diagnosis using automatic scanning of pathological slides with a microscope is only theoretically valid, and the diagnostic conclusions provided in practical applications are only for doctors' reference.

[0005] Based on the scanning principle of microscopes combined with electronic stages, one approach relies on the progress of unidirectional X-axis and Y-axis drives in the mechanical structure as the basis for image acquisition at each scanning point. Image synthesis is then performed by fusing the edge features of each acquired image. However, existing electronic stages are unsuitable for short-distance repeated movements along the X and Y axes because the structural gaps in the forward and reverse drives further amplify the error and accumulate the error. Therefore, existing electronic stages cannot acquire features at different points through short-distance forward and reverse movements to further verify the features of the previous scanning point. When the features of the previous point change, synthesis becomes difficult and distorted. Another approach requires subsequent scanning points to be continuously based on the features of the previous scanning point. This method can provide accurate sampled images for the final image synthesis when the features of the previous scanning point remain unchanged. However, when the features of the previous scanning point change or the scanning position becomes inconsistent due to errors, it cannot provide a reliable feature reference for the next scanning point, causing subsequent scanning points to change accordingly. This leads to error accumulation, ultimately resulting in inaccurate acquired images and further distortion of the synthesized image. Summary of the Invention

[0006] In view of the technical defects and related problems in the current AI diagnosis technology using artificial intelligence technology and image acquisition technology, which are due to poor accuracy and large error of the electronic stage, this invention provides a microscope electronic stage suitable for short-distance multi-point sampling along the X and Y axes.

[0007] The solution adopted by this invention to solve its technical problem is: an AI-based automatic intelligent pathological slide diagnosis image acquisition system, including a device installed on an electron microscope for image acquisition and a device with two-dimensional automatic adjustment function. A base is set on the two-dimensional automatic adjustment device, and a longitudinal slide is installed on the base through a guide structure. A longitudinal sliding drive mechanism is provided to control the longitudinal sliding of the longitudinal slide relative to the base. A transverse slide is installed on the longitudinal slide through a guide structure, and a transverse sliding drive mechanism is provided to control the transverse slide relative to the longitudinal slide. A locking mechanism for fixing the glass slide is provided on the transverse slide.

[0008] The lateral sliding drive mechanism includes a rocker arm hinged to the longitudinal sliding seat. The short arm end of the rocker arm is provided with an adjustment flat hole. A pin connected to the lateral sliding seat is fitted into the adjustment flat hole. The long arm end of the rocker arm is provided with an electric drive mechanism to enable the rocker arm to swing. The electric drive mechanism is controlled by a controller.

[0009] The longitudinal sliding drive mechanism includes a rocker arm hinged to the base. The short arm end of the rocker arm is provided with an adjustment flat hole. A pin connected to the longitudinal sliding seat is fitted into the adjustment flat hole. The long arm end of the rocker arm is provided with an electric drive mechanism to enable the rocker arm to swing. The electric drive mechanism is controlled by a controller.

[0010] The electric drive mechanism consists of an electromagnet fixed at the long arm end of the swing arm, a fixed magnet on one side of the electromagnet, and a movable magnet on the other side. When the coil of the electromagnet is energized by the controller, the electromagnet swings between the fixed magnet and the movable magnet. A component is provided to lock the movable magnet.

[0011] The component used to lock the movable magnet consists of a screw connecting the fixed magnet and the movable magnet. Specifically, a through hole is provided on the fixed magnet, and a screw hole is provided on the movable magnet. An adjusting screw passes through the through hole and is threaded into the screw hole. The distance between the fixed magnet and the movable magnet is changed by rotating the adjusting screw.

[0012] The bottom of the movable magnet and electromagnet is provided with a sliding track.

[0013] The two-dimensional automatic adjustment device includes a base, a longitudinal sliding plate, and a transverse sliding plate. A first hollow area is provided in the central region of the base, the longitudinal sliding plate is fitted into the hollow area, and a longitudinal movement device for driving the longitudinal sliding plate to slide longitudinally is installed in the hollow area. A second hollow area is provided in the central region of the longitudinal sliding plate, the transverse sliding plate is fitted into the hollow area, and a transverse movement device for driving the transverse sliding plate to slide laterally is installed in the hollow area.

[0014] Four sidewalls are formed around the edge of the first hollow area, and a longitudinal drive motor is installed on the sidewalls. A longitudinal threaded sleeve is fixed on the longitudinal slide plate. The two ends of the screw connected to the shaft of the longitudinal drive motor are installed on the corresponding sidewalls through bearings or bushings. After the screw and the longitudinal threaded sleeve are fitted together, the rotation of the drive screw can drive the threaded sleeve, i.e., the longitudinal slide plate, to move longitudinally. A support is also fixed on the longitudinal slide plate, and pulleys are installed at both ends of the support through shaft brackets and surrounded by toothed belts. A transverse drive motor is fixed on the support and drives one of the pulleys to rotate. Two transverse threaded rods, which are connected to the shafts of the two pulleys, are fixed to the sidewalls at both ends of the second hollow area through bearings or bushings. Multiple transverse threaded sleeves fixed on the transverse slide plate are threadedly connected to the transverse threaded rods. When the transverse drive motor rotates, thereby driving the transverse threaded rods to rotate, the transverse threaded sleeves and the transverse slide plate move laterally. Each motor is a linear motor, servo motor, or stepper motor.

[0015] The guide structure located between the base and the longitudinal slide is a longitudinal convex and concave structure or a track structure between the two to ensure that the longitudinal slide can always reciprocate longitudinally; the guide structure located between the longitudinal slide and the transverse slide is a transverse convex and concave structure or a track structure between the two to ensure that the transverse slide can always reciprocate transversely.

[0016] The beneficial effects of this invention are as follows: This scheme enables the electronic stage to move repeatedly over short distances along the X and Y axes without amplifying errors. It makes it possible to acquire multiple acquisition points by repeatedly moving these points along the X and Y axes. Multiple acquisition points not only improve acquisition efficiency but also allow for cross-verification of features between the acquisition points, providing precise locational information for subsequent acquisitions and accurate feature information for subsequent image synthesis. This scheme makes simultaneous multi-point acquisition possible. Using multi-point features as the basis for subsequent image acquisition avoids error accumulation, preventing acquisition failures or image synthesis distortion. This significantly improves the certainty of automated microscopic scanning of pathological slides for diagnostic purposes. Attached Figure Description

[0017] Figure 1 This is an external view of the electronic stage used in this system.

[0018] Figure 2 yes Figure 1 Cross-sectional view.

[0019] Figure 3 This is a top view of a two-dimensional automatic adjustment device.

[0020] Figure 4 This is a top view of a mechanism that moves repeatedly over short distances along the X and Y axes.

[0021] Figure 5 yes Figure 4 Internal structure diagram.

[0022] Figure 6 This is a schematic diagram of a longitudinal and transverse sliding drive mechanism.

[0023] Figure 7 This is a schematic diagram of the movement state of the longitudinal and transverse sliding drive mechanism.

[0024] Figure 8 This is a diagram showing the locking state of the locking mechanism.

[0025] Figure 9 This is a diagram showing the release state of the locking mechanism.

[0026] Figure 10 This is an external view of the locking component.

[0027] Figure 11 This is a cross-sectional view of the locking component.

[0028] Figure 12 yes Figure 11 AA cross-section view.

[0029] Figure 13 It is a control system block diagram.

[0030] Figure 14 This is a diagram of the image acquisition trajectory of an existing microscope's electronic stage.

[0031] Figure 15 This is one of the image acquisition trajectory diagrams of the microscope electronic stage of this invention.

[0032] Figure 16 This is the second image acquisition trajectory diagram of the microscope electronic stage of this invention.

[0033] Figure 17 yes Figure 15 Enlarged view of a portion of the image.

[0034] Figure 18 yes Figure 16 Enlarged view of a portion of the image.

[0035] Figure 19 This is a block diagram of an AI-based automated intelligent pathological slide diagnosis system. Detailed Implementation

[0036] The present invention will be further described below with reference to the accompanying drawings and embodiments.

[0037] Compared to the inefficiency of traditional methods that require manual observation of pathological slides according to procedures, this system provides a diagnostic system for observing and confirming diagnoses of routine pathological slides that are easily diagnosed based on obvious characteristics. Based on AI technology, this system uses image acquisition, visual measurement, detection, and diagnosis to achieve automated intelligent pathological slide diagnosis. The core of the detection system is based on a deep learning artificial intelligence engine (image enhancement and correction, image segmentation, feature extraction, image recognition and understanding, etc.): it automatically acquires modeling parameters, automatically compares the model with a standard model, and generates diagnostic results (reports).

[0038] Example 1 is an AI-based automated intelligent image acquisition system for pathological slide diagnosis, based on the microscope electron stage of Example 3. This system includes a device installed on the electron microscope for image acquisition and a device with two-dimensional automatic adjustment function. This two-dimensional automatic adjustment device can be a traditional two-dimensional adjustment device, or it can be... Figure 3 The two-dimensional adjustment device is shown. This system also relies on the progress of the X-axis and Y-axis unidirectional drives in the mechanical structure as the basis for image acquisition at each scanning point, and fuses the images based on the edge features of each acquired image during image synthesis.

[0039] Example 2 is based on the microscope electronic stage in Example 3. Another approach is that subsequent scanning points need to be based on the characteristics of the previous scanning point. This approach can provide accurate sampled images for the final image synthesis while ensuring that the characteristics of the previous scanning point do not change.

[0040] Example 3: A microscope electronic stage suitable for short-distance multi-point sampling along the X and Y axes. The slide is placed on a substrate with shallow grooves. This substrate can be moved along the Y-axis by a Y-axis stepper motor. The Y-axis movement mechanism is entirely placed on a base and moved along the X-axis by an X-axis stepper motor. Note that the substrate needs to be perpendicular to the microscope lens to replace the microscope stage.

[0041] Figure 1 This refers to the overall appearance of the electronic stage. Figure 2 Internal structure of the monitor Figure 3 It is a two-dimensional automatic adjustment device. Specifically, the two-dimensional automatic adjustment device includes a base 1, a longitudinal sliding plate 3, and a transverse sliding plate 5. A hollow area 2 is set in the central area of ​​the base 1. The longitudinal sliding plate 3 is fitted into the hollow area, and a longitudinal movement device that drives the longitudinal sliding plate 3 to slide longitudinally is installed in the hollow area. As can be seen from the figure, the width of the longitudinal sliding plate 3 is significantly smaller than the width of the hollow area 2, so that the longitudinal sliding plate 3 has sufficient longitudinal movement space.

[0042] A hollow area 4 is further provided in the center of the longitudinal sliding plate 3, and the transverse sliding plate 5 is fitted into this hollow area. A lateral movement device that drives the transverse sliding plate 5 to slide laterally is installed in this hollow area. As can be seen from the figure, the length of the transverse sliding plate 5 is significantly smaller than the length of the hollow area 4, so that the longitudinal sliding plate 3 has sufficient lateral movement space.

[0043] A two-dimensional automatic adjustment device is used to move the glass slide a sufficient distance along the X and Y axes, therefore it is driven by a linear motor or stepper motor. Figure 3 As can be seen, four side walls are set around the edge of the hollow area 2, and a longitudinal drive motor 9 is installed on the side walls. A longitudinal threaded sleeve 8 is fixed on the longitudinal slide plate 3. The two ends of the screw 7, which is connected to the rotating shaft of the longitudinal drive motor 9, are installed on the corresponding side walls through bearings or bushings. After the screw 7 and the longitudinal threaded sleeve 8 are fitted together, the rotation of the drive screw 7 can drive the threaded sleeve, i.e., the longitudinal slide plate 3, to move longitudinally. In the figure, 13 is a guide rod fixed to the two side walls, and 14 is a guide sleeve fixed to the longitudinal slide plate 3. A support 6 is fixed on the longitudinal slide plate 3, with pulleys mounted on both ends via shaft brackets and toothed belts 12 wrapped around them. A transverse drive motor 10 is fixed on the support and drives one of the pulleys to rotate. Two transverse screws 15, which are connected to the shafts of the two pulleys, are fixed to the side walls of the two ends of the hollow area 4 via bearings or bushings. Multiple transverse threaded sleeves 16 fixed on the transverse slide plate 5 are threadedly connected to the transverse screws 15. When the transverse drive motor 10 rotates, thereby driving each transverse screw 15 to rotate, each transverse threaded sleeve 16 and the transverse slide plate 5 move laterally. Each motor can be a linear motor (equipped with a 0.1-micron grating ruler), a servo motor (equipped with a 0.1-micron encoder), or a stepper motor.

[0044] As can be seen, the two-dimensional automatic adjustment device can drive the slide to move arbitrarily in a two-dimensional plane along the X and Y axes, with a maximum travel area of ​​150mm*100mm. It adopts a compact, integrated design and provides abundant interfaces above and below the stage for easy installation and use. The use of a DC motor ensures the product's rapid performance. However, this screw-driven movement process has poor precision. For electron microscope image acquisition at 100x magnification, travel errors can easily affect the accuracy of image acquisition. Moreover, this translational relationship based on the screw and sleeve is not suitable for repeated movement along a single axis. Repeated movement will further increase the amount of error and the error accumulation effect. Therefore, relying solely on the two-dimensional automatic adjustment device can only achieve... Figure 14 The image acquisition path shown cannot achieve the desired result. Figure 15 and Figure 16 The image acquisition path shown cannot achieve the function of multi-point image acquisition in the form of continuous areas.

[0045] Therefore, it is necessary to... Figure 3 Based on the two-dimensional automatic adjustment device shown, a further design is made, such as... Figure 4 and Figure 5 As shown, a base 17 is provided on the basis of the two-dimensional automatic adjustment device, and the base 17 can be directly fixed to... Figure 3 The middle part of the horizontal sliding plate 5 of the two-dimensional automatic adjustment device.

[0046] A longitudinal slide block 18 is mounted on the base 17 via a guide structure. The longitudinal guide structure can be a longitudinal convex-concave structure or a track structure set between the two to ensure that the longitudinal slide block 18 can always reciprocate longitudinally. A longitudinal sliding drive mechanism 23 is provided to control the longitudinal sliding of the longitudinal slide block 18 relative to the base 17.

[0047] A transverse slide 19 is mounted on the longitudinal slide 18 via a guide structure. The transverse guide structure can be a transverse convex-concave structure or a track structure set between the two to ensure that the transverse slide 19 can always reciprocate in the transverse direction. A transverse sliding drive mechanism 22 is provided to control the longitudinal sliding of the transverse slide 19 relative to the longitudinal slide 18.

[0048] The longitudinal slide 18 and the transverse slide 19 have very small reciprocating movements along the longitudinal direction and the transverse slide 19 have very small reciprocating movements along the transverse direction. Therefore, the area for designing their convex and concave structures or track structures is small and short, but accuracy must be guaranteed.

[0049] Both the horizontal sliding drive mechanism 22 and the vertical sliding drive mechanism 23 include a swing arm 24 hinged to the base (the lower part). An adjustment flat hole 26 is provided at the short arm end of the swing arm 24. A pin 27, connected to the moving body (the upper part), is fitted into the adjustment flat hole 26. An electric drive mechanism is provided at the long arm end of the swing arm 24 to enable the swing arm 24 to swing. The electric drive mechanism is controlled by a controller. It can be seen that the electric drive mechanism is intended to provide a short-distance reciprocating control drive. Therefore, this stage enables the electrification of the microscope XY stage, featuring fast response speed, good stability, high repeatability, high-speed scanning capability, and high positioning accuracy. This stage is an ideal choice for manually or automatically positioning large areas of specimens and samples in various types of microscopes or imaging techniques and applications.

[0050] Meanwhile, a locking mechanism for fixing the glass slide is provided on the horizontal slide 19.

[0051] like Figure 5 As shown, the locking mechanism includes a right-angle bracket 32 ​​for supporting the top corner of the slide. An adjusting rod 1 and an adjusting rod 2 are hinged to the rear side of the right-angle bracket 32 ​​by one or two pins. At the same time, a rotatable locking component 1 36 and a locking component 2 37 are vertically hinged at different positions on the upper side of the horizontal slide 19. The adjusting rod 1 and the adjusting rod 2 pass through the locking component 1 36 and the locking component 2 37 respectively and can be locked.

[0052] Specifically, such as Figures 10-12 As shown, each locking component includes a rotating body 38, the bottom of which is hinged to the horizontal slide 19 and can rotate. Each rotating body 38 contains a threaded cavity and is fitted with a set screw 39. A radial through-hole is provided at the lower part of each rotating body 38, through which two adjusting rods are fitted. A U-shaped pad 40 is fitted inside the threaded cavity of the rotating body 38 to secure the corresponding adjusting rod. The set screw 39, located in the threaded cavity, presses against the upper side of the U-shaped pad 40, thereby locking the adjusting rod. It can be seen that the set screw 39 and the U-shaped pad 40 can lock the corresponding adjusting rod, preventing it from sliding axially. Simultaneously locking adjusting rod one and adjusting rod two respectively prevents the rotating bodies 38 of the two locking components from rotating, thus ensuring that the right-angle holder 32 can be adjusted and locked in any position, adapting to the installation and use of slides of different sizes.

[0053] In addition, such as Figure 8As shown, when a slide 41 of the appropriate size is installed in the recessed area 20 in the middle of the horizontal slide 19, a chamfered baffle 21 is also provided at its apex. The two sides of the recessed area 20 can restrain the slide from rotating, and the chamfered baffle 21 can restrain the slide from leaving the recessed area. The right-angle bracket 32 ​​supports the other two sides of the slide from the other apex, preventing the slide from coming out. Thus, the locking mechanism can flexibly and firmly fix the slide in the designated position on the horizontal slide 19, thereby ensuring its stability during frequent lateral and longitudinal swinging.

[0054] During operation, the system utilizes a two-dimensional automatic adjustment device to achieve overall horizontal or vertical movement of the slide. Simultaneously, within each horizontal or vertical movement zone, the controller drives both the horizontal sliding mechanism 22 and the vertical sliding mechanism 23, causing the slide to simultaneously perform a circular movement within that zone. The circular movement includes scenarios such as... Figure 15 He Ru Figure 16 As shown, Figure 17 yes Figure 15 The exploded diagram of the circular movement shows that as the slide moves along the X-axis, steps ① through ④ are performed. Each step is considered a region. Within this region, steps ① and ③ represent the reciprocating movement of the slide along the X-axis by the transverse sliding drive mechanism 22, while steps ② and ④ represent the reciprocating movement of the slide along the Y-axis by the longitudinal sliding drive mechanism 23. Steps ① through ④ constitute one cycle of image acquisition for this region. At least four images can be acquired quickly within this cycle, which not only improves the acquisition speed but also provides more feature extraction vectors from multiple simultaneously acquired images. This ensures that the coordinates and features correspond during subsequent image acquisition, guaranteeing the accuracy and reliability of the final image acquisition. Figure 16 and Figure 18 This is a composite motion state that combines the longitudinal and transverse movements of the longitudinal slide block 18 and the transverse slide block 19 with the transverse axis movement of the two-dimensional automatic adjustment device. This state ensures that the transverse or longitudinal movement of the two-dimensional automatic adjustment device is at a uniform speed. Figure 19 As shown, by determining the coordinates of a single sample area and collecting sample image information, and through image saliency analysis and feature extraction within that area, a feature vector is formed and imported into the recognition algorithm. This results in a single-area image and its accurate coordinates. The single-area image features and accurate coordinates provide a reliable basis for subsequent sample collection, and the single-area image combined with its coordinates provides the foundation for the final sample image synthesis. During the diagnostic process, after feature extraction and classification training of training samples, the sample-trained classifier and the synthesized image are imported into the recognition algorithm to obtain the final recognition result.

[0055] Example 4: Based on Example 3, such as Figures 5-7As shown, the horizontal sliding drive mechanism 22 includes a rocker arm 24 hinged to the vertical sliding base 18 via a pivot 25. An adjustment flat hole 26 is provided at the short arm end of the rocker arm 24, and a pin 27 connected to the horizontal sliding base 19 is fitted into the adjustment flat hole 26. An electric drive mechanism is provided at the long arm end of the rocker arm 24 to enable the rocker arm 24 to swing. The electric drive mechanism is controlled by a controller. The vertical sliding drive mechanism 23 includes a rocker arm 24 hinged to the base 17. An adjustment flat hole 26 is provided at the short arm end of the rocker arm 24, and a pin 27 connected to the vertical sliding base 18 is fitted into the adjustment flat hole 26. An electric drive mechanism is provided at the long arm end of the rocker arm 24 to enable the rocker arm 24 to swing. The electric drive mechanism is controlled by a controller.

[0056] The electric drive mechanism consists of an electromagnet 28 fixed at the long arm end of the swing arm 24, a fixed magnet 29 on one side of the electromagnet 28, and a movable magnet 30 on the other side. When the coil of the electromagnet 28 is energized by the controller, the electromagnet 28 swings between the fixed magnet 29 and the movable magnet 30. A locking component is provided for the movable magnet 30. The locking component for the movable magnet 30 consists of a screw connecting the fixed magnet 29 and the movable magnet 30. Specifically, a through hole is provided in the fixed magnet 29, and a screw hole is provided in the movable magnet 30. An adjusting screw passes through the through hole and is threaded into the screw hole. Rotating the adjusting screw changes the distance between the fixed magnet 29 and the movable magnet 30. A sliding track 31 is provided at the bottom of the movable magnet 30 and the electromagnet 28.

[0057] It can be seen that the lever 24 is a lever structure with a long arm and a short arm. The electromagnet 28 is used to drive the long arm end. The ratio of the long arm to the short arm is 15-30:1, which is a large ratio. The short distance accuracy can reach 0.1 micrometers. Moreover, the range of variation of the long shaft end and the distance between the fixed magnet 29 and the movable magnet 30 can be adjusted, so that the short arm moves a small distance with high accuracy.

[0058] Example 5: Based on Example 3, an improvement is made to the two-dimensional automatic adjustment device. The substrate used to support the glass slide is small in size and light in weight, and its overall strength is not enough to support the bulky stepper motor. To integrate and simplify it, an X-axis screw drives the nut to achieve X-axis movement. The X-axis screw also drives a Y-axis driven bevel gear through an active bevel gear. The nut sleeve and the driven bevel gear sleeve are opened and closed by electromagnetic control, so that when X-axis movement is needed, the nut sleeve is locked and the driven bevel gear sleeve is released, and when Y-axis movement is needed, the nut sleeve is released and the driven bevel gear is locked.

Claims

1. An AI-based automated intelligent image acquisition system for pathological slide diagnosis, comprising an image acquisition device mounted on an electron microscope and a device with two-dimensional automatic adjustment function, characterized in that, A base (17) is set on the basis of the two-dimensional automatic adjustment device. The base is fixed to the middle of the horizontal sliding plate of the two-dimensional automatic adjustment device. The ratio of the length of the long arm to the short arm of the swing arm is 15-30:

1. A longitudinal sliding seat (18) is installed on the base (17) through a guide structure. A longitudinal sliding drive mechanism (23) is provided to control the longitudinal sliding seat (18) to slide longitudinally relative to the base (17). A horizontal sliding seat (19) is installed on the longitudinal sliding seat (18) through a guide structure. The slide is provided with a horizontal sliding drive mechanism (22) that controls the horizontal slide (19) to slide longitudinally relative to the vertical slide (18). The horizontal slide (19) is provided with a locking mechanism for fixing the glass slide. The horizontal sliding drive mechanism (22) includes a rocker arm (24) hinged to the vertical slide (18) via a pivot (25). The short arm end of the rocker arm (24) is provided with an adjusting flat hole (26). A pin (27) connected to the horizontal slide (19) is fitted into the adjusting flat hole (26). 6) Inside, the long arm end of the swing rod (24) is provided with an electric drive mechanism to enable the swing rod (24) to swing. The electric drive mechanism is controlled by the controller; the longitudinal sliding drive mechanism (23) includes a swing rod (24) hinged to the base (17). The short arm end of the swing rod (24) is provided with an adjustment flat hole (26). A pin (27) connected to the longitudinal sliding seat (18) is fitted into the adjustment flat hole (26). The long arm end of the swing rod (24) is provided with an electric drive mechanism to enable the swing rod (24) to swing. 24) It can swing, and the electric drive mechanism is controlled by the controller; the electric drive mechanism is an electromagnet (28) fixed at the long arm end of the swing rod (24), a fixed magnet (29) is provided on one side of the electromagnet (28), and a movable magnet (30) is provided on the other side. When the coil of the electromagnet (28) is energized by the controller, the electromagnet (28) swings between the fixed magnet (29) and the movable magnet (30). A component is provided to lock the movable magnet.

2. The image acquisition system according to claim 1, characterized in that, The component used to lock the movable magnet (30) is a screw connecting the fixed magnet (29) and the movable magnet (30). Specifically, a through hole is provided in the fixed magnet (29), and a screw hole is provided in the movable magnet (30). An adjusting screw passes through the through hole and is threaded into the screw hole. The distance between the fixed magnet (29) and the movable magnet (30) is changed by rotating the adjusting screw.

3. The image acquisition system according to claim 1 or 2, characterized in that, The bottom of the movable magnet (30) and the electromagnet (28) is provided with a sliding track (31).

4. The image acquisition system according to claim 1, characterized in that, The two-dimensional automatic adjustment device includes a base (1), a longitudinal slide plate (3), and a transverse slide plate (5). A hollow area 1 (2) is set in the central area of ​​the base. The longitudinal slide plate (3) is fitted into the hollow area, and a longitudinal movement device for driving the longitudinal slide plate (3) to slide longitudinally is installed in the hollow area. A hollow area 2 (4) is set in the central area of ​​the longitudinal slide plate (3). The transverse slide plate (5) is fitted into the hollow area, and a transverse movement device for driving the transverse slide plate (5) to slide laterally is installed in the hollow area.

5. The image acquisition system according to claim 4, characterized in that, Four side walls are set around the edge of the hollow area (2), and a longitudinal drive motor (9) is installed on the side walls. A longitudinal threaded sleeve (8) is fixed on the longitudinal slide plate (3). The two ends of the screw (7) connected to the shaft of the longitudinal drive motor (9) are installed on the corresponding side walls through bearings or bushings. After the screw (7) and the longitudinal threaded sleeve (8) are fitted together, the rotation of the drive screw (7) can drive the threaded sleeve, i.e. the longitudinal slide plate (3), to move longitudinally. A support (6) is also fixed on the longitudinal slide plate (3), and pulleys are installed at both ends of the support through the shaft frame. A toothed belt (12) is wrapped around the support. A transverse drive motor (10) is fixed on the support and drives one of the pulleys to rotate. Two transverse screws (15) that are connected to the shafts of the two pulleys are fixed to the side walls of the two ends of the hollow area (4) by bearings or bushings. Multiple transverse sleeves (16) fixed on the transverse slide plate (5) are threadedly connected to the transverse screws (15). When the transverse drive motor (10) rotates and drives each transverse screw (15) to rotate, each transverse sleeve (16) and the transverse slide plate (5) move laterally.

6. The image acquisition system according to claim 5, characterized in that, Each motor is a linear motor, servo motor, or stepper motor.

7. The image acquisition system according to claim 1, characterized in that, The guide structure located between the base (17) and the longitudinal slide (18) is a longitudinal convex and concave structure or a track structure between the two to ensure that the longitudinal slide (18) can always move back and forth in the longitudinal direction; the guide structure located between the longitudinal slide (18) and the transverse slide (19) is a transverse convex and concave structure or a track structure between the two to ensure that the transverse slide (19) can always move back and forth in the transverse direction.

Images