A two-way displacement fully sealed thermal cover system and driving method

Abstract

The present invention relates to a two-way displacement fully sealed hot cover system and a driving method, comprising a hot cover and a displacement driving module which are not fixedly connected to each other. The hot cover inside a cartridge is driven to perform required horizontal and vertical displacements through a separate external displacement driving module, so as to achieve required hot cover displacement activities and ensure that sufficient effective operating space is provided above a PCR tube for operation of other functional components such as a pipette after the hot cover is opened. The hot cover which is separately arranged in the cartridge can simply use elastic sealing materials to ensure the sealing of the cartridge during the displacement process, and the manufacturing is simple and low in cost, so the hot cover is an ideal solution for heating the hot cover in the library preparation process.

Description

Technical Field

[0001] The present invention relates to the technical field of gene detection, and in particular to a two-way displacement fully sealed thermal cover system and a driving method. Background Art

[0002] During the library preparation PCR process, the reaction well will be heated to a predetermined temperature. To prevent the water in the main reaction well sample from evaporating and condensing on the PCR tube cover, the PCR tube cover usually needs to be heated. Compared with the method of adding paraffin oil to prevent evaporation, using a hot cover for heating avoids the problem of difficult removal of paraffin oil after the reaction is completed, and has become a commonly used solution.

[0003] Most of the hot covers used in the prior art come from the thermal cycler structure, corresponding to the fixed structure of the 96-well plate or PCR strip tube. When heating is required, the motor drives the active structure to compress the PCR tube cover and use the hot cover (such as PI heating film) to heat the PCR tube cover. The hot cover structure used in the prior art can well realize the heating of the PCR tube cover, but it cannot be directly applied in the library preparation process. Compared with the simple PCR thermal cycle process, the library preparation process is more complicated. In addition to heating, it is also necessary to use components such as pipettes for operations such as sample addition and pipetting. It is obviously necessary to control the opening and closing of the hot cover according to the operating steps and provide available operating space for other functional components (such as pipettes), and the heating effect of the hot cover cannot be considered alone; on the other hand, in order to ensure the reliability of the prepared library, the entire library preparation process needs to be kept in a sealed state and completely isolated from the external environment to ensure that the sample will not be contaminated. Therefore, it is required that the opening and closing actions of the hot cover cannot destroy the sealing of the entire cassette.

[0004] It can be seen that the biggest difficulty encountered in applying the hot cover technology in the library preparation process is the need to achieve a large range of movable displacement of the hot cover to provide sufficient operating space, and at the same time, it is necessary to ensure that the displacement of the hot cover does not destroy the sealing integrity of the cartridge at any stage. Furthermore, for disposable cartridges, excessively high production costs are unacceptable, so the hot cover structure also needs to ensure low production costs and processing difficulty. Summary of the invention

[0005] In order to solve the deficiencies of the prior art, the present invention proposes a two-way displacement fully sealed hot cover system and a driving method, which drives the hot cover inside the cartridge to perform the required horizontal and vertical displacements through a separate external displacement driving structure, thereby achieving the required hot cover displacement activity and ensuring that there is sufficient effective operating space above the PCR tube for the operation of other functional components such as a pipette after the hot cover is opened; the hot cover separately arranged in the cartridge can simply use elastic sealing materials to ensure the sealing of the cartridge during the displacement process, and is simple to manufacture and low in cost, and is an ideal hot cover heating solution for the library preparation process.

[0006] To achieve the above objectives, the technical solutions adopted by the present invention include:

[0007] A two-way displacement fully sealed thermal cover system, characterized by comprising a thermal cover and a displacement drive module which are not fixedly connected to each other;

[0008] The heat cover is sealed and arranged on the wall of the cartridge by an elastic seal member so as to be able to move in and out horizontally and / or move up and down vertically, and the heat cover is kept horizontal and faces the reaction hole to be heated;

[0009] The displacement driving module is arranged outside the card box, and drives the thermal cover to perform one or more displacements of horizontal entry, horizontal exit, vertical ascent, and vertical descent.

[0010] Furthermore, the thermal cover stays in the thermal cover open position by the elasticity of the elastic sealing member when not subjected to external force, and the thermal cover open position is the position where the thermal cover horizontally withdraws to the limit position and vertically rises to the natural position without external force; the displacement driving module provides external force to drive the thermal cover to move and stay in the thermal cover closed position, and the thermal cover closed position is the position where the thermal cover horizontally enters to the limit position and vertically descends to the limit position and covers and closes the reaction hole.

[0011] Furthermore, the elastic seal comprises an elastic member of an accordion cover structure that can be retracted and deformed, and the elastic seal maintains a contracted state when not acted upon by an external force and provides a force tending to return to the contracted state when stretched by an external force.

[0012] Furthermore, the elastic sealing element includes a silicone film or a soft rubber film.

[0013] Furthermore, the displacement driving module at least drives the thermal cover to move horizontally, vertically upward, and vertically downward.

[0014] Furthermore, the thermal cover comprises a heating seat and a cover body assembly arranged on the bottom surface of the heating seat, and the heating seat is sealed and connected to the wall surface of the card box through the elastic sealing member so as to be horizontally movable in and out and / or vertically movable up and down; the heating seat is provided with a driving groove opening toward the external environment, and the driving groove has at least a horizontal upper surface, a horizontal lower surface formed by the upper surface of the cover body assembly, and a vertical surface.

[0015] Furthermore, the displacement driving module includes a driving arm, the size of which corresponds to the driving slot, and the driving arm drives the cover body assembly to move vertically upward, vertically downward or horizontally by being inserted into the driving slot and pushing against the horizontal upper surface, horizontal lower surface or vertical surface in the driving slot; a heating assembly is provided at one end of the driving arm inserted into the driving slot.

[0016] Furthermore, the displacement driving module further comprises a fixing seat fixedly arranged relative to the card box, and a driving motor and a driving guide structure installed on the fixing seat;

[0017] The driving motor rotates forward and reversely according to the control instruction to provide power for driving the driving arm to move;

[0018] The driving guide structure includes a lead screw driven to rotate by the driving motor and a linear guide shaft parallel to the lead screw, and a driving block installed on the lead screw and the linear guide shaft and horizontally entering and exiting displacements with the positive and reverse rotations of the lead screw; the driving block is connected to the driving arm through a connecting rod; a guide groove is also provided on the fixed seat, and the driving arm is also fixedly connected to a cam follower, which is installed in the guide groove on the fixed seat and limits the displacement of the driving arm along the guide groove; the guide groove includes a connected horizontal section and a vertical section, and the cam follower is horizontally displaced through the horizontal section and then vertically displaced downward through the vertical section.

[0019] Furthermore, two parallel connecting rods are respectively provided on both sides of the driving block to connect the driving arms.

[0020] Furthermore, a guide protrusion is provided at the connection position between the horizontal section and the vertical section of the guide groove, and the cam follower is vertically displaced upward via the guide protrusion.

[0021] Furthermore, the driving guide structure also includes a sliding block slidably mounted on the lead screw and the linear guide shaft, and the sliding block includes a horizontal slide and a vertical guide rail fixedly connected to each other; the sliding block and the end of the driving arm away from the thermal cover are connected through a vertical guide rail and limit the sliding block and the driving arm to only be able to perform relative displacement in the vertical up and down directions.

[0022] Furthermore, the horizontal slide is fixedly provided with a guide rod penetrating the driving arm, and the sliding block and the driving arm are connected through a vertical guide rail and the guide rod limits the relative displacement between them only in the vertical up-and-down direction;

[0023] A pre-compression spring is sleeved on the guide rod. The pre-compression spring is located between the horizontal slide and the driving arm and provides a force to drive the horizontal slide and the driving arm to move vertically away from each other.

[0024] Furthermore, the heating component includes a PI heating film, a ceramic heating plate, a Peltier, a silicone heating plate or a mica heating plate.

[0025] Furthermore, the heating component is also provided with a temperature sensor.

[0026] The present invention also relates to a two-way displacement fully sealed heat cover driving method, which is characterized in that a single driving motor is used to drive the heat cover to perform horizontal displacement and vertical displacement in sequence to complete the heat cover closing displacement operation or the heat cover opening displacement operation.

[0027] Furthermore, the thermal cover closing displacement operation includes driving the motor to rotate forward to drive the thermal cover to move horizontally to the top of the reaction hole, and then move vertically downward to cover and compact the reaction hole; the thermal cover opening displacement operation includes driving the motor to rotate backward to drive the thermal cover to move vertically upward to release the reaction hole, and then the force of the elastic sealing member tending to return to the contracted state drives the thermal cover to move horizontally out of the reaction hole to make room for the space directly above the reaction hole.

[0028] Furthermore, the thermal cover closing displacement operation includes the following steps: the driving motor rotates forward to drive the driving arm to push the thermal cover horizontally to the top of the reaction hole, and then continues to push the thermal cover vertically downward to cover and compact the reaction hole; the thermal cover opening displacement operation includes the driving motor rotates reversely to drive the driving arm to push the thermal cover vertically upward to release the reaction hole, and then exits horizontally to break away from contact with the thermal cover.

[0029] The beneficial effects of the present invention are:

[0030] The two-way displacement fully sealed thermal cover system and driving method of the present invention are used to cover and heat the reaction wells in the library preparation process, which can ensure the integrity of the sealing of the cartridge while realizing the horizontal and vertical displacement of the thermal cover structure according to the operation needs, without affecting the operation of the reaction wells by other functional components in the cartridge, thereby avoiding external contamination of the sample due to the displacement of the thermal cover; at the same time, there is no rigid connection between the displacement driving module and the thermal cover, and the relatively high-cost displacement driving module can be easily and independently arranged outside the cartridge, thereby greatly reducing the manufacturing cost and difficulty of the cartridge, and being more suitable for making disposable cartridges. A higher-precision driving component can also be used as needed to improve the efficiency and accuracy of the library preparation experiment. BRIEF DESCRIPTION OF THE DRAWINGS

[0031] Figure 1 It is a three-dimensional schematic diagram of a preferred embodiment of the two-way displacement fully sealed thermal cover system of the present invention.

[0032] Figure 2 This is a schematic diagram of the opening position of the hot cover in a preferred embodiment of the present invention.

[0033] Figure 3 This is a schematic diagram of the closed position of the thermal cover in a preferred embodiment of the present invention.

[0034] Figure 4 It is a schematic side view of a thermal cover according to a preferred embodiment of the present invention.

[0035] Figure 5 It is a three-dimensional schematic diagram of a thermal cover according to a preferred embodiment of the present invention.

[0036] Figure 6 Schematic diagram of a driving arm according to a preferred embodiment of the present invention.

[0037] Figure 7 It is a schematic diagram of a fixing seat according to a preferred embodiment of the present invention.

[0038] Explanation of the accompanying figures: 11-heating seat, 12-cover assembly, 13-elastic seal, 21-driving arm, 211-connecting rod, 212-cam follower, 213-heating assembly, 214-temperature sensor, 22-fixed seat, 221-guide groove, 23-driving motor, 241-screw, 242-linear guide shaft, 243-driving block, 244-sliding block, 2441-horizontal slide, 2442-vertical guide rail, 2443-guide rod, 2444-pre-compression spring, 3-reaction hole, 4-card box. DETAILED DESCRIPTION

[0039] In order to more clearly understand the content of the present invention, it will be described in detail with reference to the drawings and embodiments.

[0040] When using a hot cover system to heat the reaction wells during library preparation, it is necessary to ensure that the sealing of the library preparation cartridge is intact and that the operability of other functional components is not affected. In essence, the hot cover (cover assembly) is not only required to perform a single-dimensional vertical displacement to normally close and open the hot cover, but also to provide an appropriate displacement method to ensure that the hot cover is opened to allow the operating space directly above the reaction well for other functional components in the cartridge (such as a pipette) to operate the reaction well. More complex displacement requirements not only cause problems for the cartridge sealing, but also directly lead to a more complex and more expensive hot cover structure, which is not well suited for disposable cartridges.

[0041] In order to solve the relative contradiction between the complex displacement, sealing and low cost of the thermal cover system, the present invention adopts a solution in which the thermal cover and the displacement drive module are separately arranged. The thermal cover is directly arranged on the cartridge by an elastic seal, forming a whole with the cartridge (the wall of the cartridge), ensuring the sealing of the cartridge, and using an external displacement drive module to drive the thermal cover to perform the required displacement to realize the thermal cover function. While solving the complex displacement and sealing problems, the external displacement drive module can be reused, reducing the cost of the cartridge part (disposable part), and breaking away from the premise of cost constraints also facilitates the use of more efficient drive components as needed, which helps to improve the efficiency and accuracy of library preparation.

[0042] Figure 1 , Figure 2 and Figure 3 A preferred embodiment of the two-way displacement fully sealed thermal cover system of the present invention is provided, which mainly comprises a thermal cover and a displacement drive module. The thermal cover part comprises a heating seat 11, a cover assembly 12 and an elastic seal 13, such as Figure 4 and Figure 5 The structure diagram of the heat cover part is shown. The heating seat 11 is sealed and connected with the wall of the cartridge 4 by the elastic seal 13 to form a whole. At the same time, the elastic seal 13 can support the heating seat 11 to move horizontally in and out and / or vertically up and down relative to the cartridge 4. Preferably, the heating seat 11 and the elastic seal 13 are made of the same elastic material and are integrally formed to achieve a more reliable sealing effect; the bottom surface of the heating seat 11 is fixedly provided with a cover assembly 12, the size of the cover assembly 12 matches the reaction hole 3, and can cover the closed reaction hole 3; the upper surface of the cover assembly 12 and the surface of the heating seat 11 concave into the cartridge 4 constitute a driving groove with a horizontal upper surface, a horizontal lower surface and a vertical surface. Preferably, in the case of no additional external force, the heating seat 11 and the cover assembly 12 are kept in the open position of the heat cover by the elasticity of the elastic seal 13 itself, and the elasticity of the elastic seal 13 can provide a force tending to return to the open position of the heat cover when it is displaced by an external force. According to the requirements, the elastic seal 13 can be an accordion cover structure elastic member made of materials such as silicone film or soft rubber film. Since the card box 4 is disposable, the elastic seal 13 does not particularly need to consider the durability of use. In fact, in order to better control the cost, the elastic seal 13 can choose a component with relatively low performance but low cost under the premise of meeting the use requirements. In the preferred embodiment, the heating function is not integrated in the heat cover part, and in order to better control the cost of the card box 4, the heating function is integrated in the external component to achieve reuse and avoid waste; of course, those skilled in the art should be able to understand without any obstacles that integrating the heating function in the heat cover part, such as directly integrating it in the cover assembly 12, is conceivable and easy to implement, and will not affect the main technical solution of the present invention.

[0043] The above-mentioned heat cover part can solve the sealing problem of the card box 4, and the manufacturing cost of the card box 4 can also be well controlled. On this basis, the external displacement drive module does not have strict cost restrictions, so a suitable drive structure can be selected according to needs. In the preferred embodiment, a structure in which a single motor drives the drive arm 21 to regularly move horizontally and vertically is adopted, and then the displacement of the heat cover is achieved by pushing the drive arm 21 against the heat cover (the drive slot in the heating seat 11). The displacement drive module in the preferred embodiment includes a drive arm 21 (such as Figure 6 As shown), a fixing seat 22 fixedly arranged relative to the card box 4 (as shown Figure 7 As shown in the figure, as well as the driving motor 23 and the driving guide structure installed on the fixing seat 22, since only a single driving motor 23 is used to realize the horizontal and vertical displacement of the driving arm 21, it is necessary to use the driving guide structure to further realize the displacement of the driving arm 21 along the set path while using the screw rod 241, the linear guide shaft 242 and the driving block 243 to convert the rotational motion of the driving motor 23 into horizontal linear motion. Specifically, the driving guide structure also includes a connecting rod 211 connecting the driving block 243 and the driving arm 21 and a guide groove 221 provided on the fixing seat 22. The driving arm 21 is limited to be displaced only along the guide groove 221 by the fixedly connected cam follower 212. The connecting rod 211 can directly transmit the horizontal displacement of the driving block 243 to the driving arm 21, and can also realize the conversion of the horizontal displacement of the driving block 243 into the vertical displacement of the driving arm 21. Preferably, the guide groove 221 includes a horizontal section and a vertical section connected to each other. When the cam follower 212 runs in the horizontal section, the vertical distance between the connection points of the driving arm 21 connected at both ends of the connecting rod 211 and the connection points of the driving block 243 does not change, and the driving arm 21 synchronously executes horizontal entry and horizontal exit displacements with the driving block 243; when the cam follower 212 runs in the vertical section, the vertical distance between the connection points of the driving arm 21 connected at both ends of the connecting rod 211 and the connection points of the driving block 243 changes, thereby changing the driving action direction, and the driving arm 21 executes vertical downward and vertical upward displacements with the horizontal entry and horizontal exit displacements of the driving block 243, so that the driving arm 21 forms a 90° zigzag travel route as a whole. Further preferably, a guide protrusion is provided at the connection position between the horizontal section and the vertical section of the guide groove 221. When the cam follower 212 runs to the guide protrusion, the driving arm 21 will perform a vertical upward displacement, so that the driving arm 21 moves to a position higher than the vertical height when the cam follower 212 runs in the horizontal section. This can more fully enable the driving arm 21 to push against the horizontal upper surface in the driving groove, thereby assisting the cover body assembly 12 and the reaction hole 3 to separate from each other.

[0044] Through the displacement drive module of the above structure, the driving arm 21 can be horizontally and vertically displaced according to the required path. At the same time, the heating component 213 arranged at one end of the driving arm 21 can align with the cover component 12 when the driving arm 21 is vertically displaced downward, and then combined into a complete hot cover with heating ability, so as to realize the closed heating operation of the reaction hole 3; preferably, a temperature sensor 214 is arranged at a position close to the heat source on the heating component 213, and the heating component 213 can be controlled according to the real-time temperature detected by the temperature sensor 214, so as to flexibly adjust the heating temperature of the hot cover (reaction hole 3). As mentioned above, the main purpose of arranging the heating component 213 on the driving arm 21 is to further reduce the cost and structural complexity of the cartridge 4, and to realize the reusability of more functional components as much as possible. According to actual needs, the design of integrating the heating component 213 on the cover component 12 (integrated into the cartridge 4) can also be adopted.

[0045] Since the cam follower 212 uses a clearance fit in the guide groove 221 and cannot provide sufficient limiting capability, deflection may occur when the driving arm 21 is vertically displaced, resulting in the heating component 213 and the cover component 12 being unable to maintain parallel alignment. The additional force generated will further affect the horizontal state of the cover component 12 and further affect the closure of the cover component 12 and the reaction hole 3, resulting in a loose closure and affecting the reaction. Therefore, in order to improve the stability of the driving arm 21 in the displacement state, the displacement driving module further preferably includes a sliding block 244, and the sliding block 244 includes a horizontal slide 2441 and a vertical guide rail 2442 that are integrally formed or fixedly connected to each other. The horizontal slide 2441 is installed on the screw rod 241 and the linear guide shaft 242 and can slide freely horizontally along the screw rod 241 and the linear guide shaft 242. The end of the driving arm 21 away from the heat cover is connected to the vertical guide rail 2442, which limits the driving arm 21 to only be able to perform vertical displacement relative to the sliding block 244. In this way, a limiting structure is added to the displacement activity of the driving arm 21 outside the cam follower 212 to limit the driving arm 21 from undesirable deflection displacement. Optionally, a pre-compression spring 2444 can be set between the horizontal slide 2441 and the driving arm 21 to apply additional force to the end of the driving arm 21 (the end away from the heat cover) to help maintain the horizontal state of the driving arm 21. The pre-compression spring 2444 is preferably mounted on a guide rod 2443 to avoid misalignment during compression and extension.

[0046] When the hot cover system as shown in the preferred embodiment is used, the hot cover (heating seat 11) is normally in the hot cover open position. According to the control instruction, the driving motor 23 rotates in the positive direction to drive the driving block 243 to enter horizontally. At this time, the cam follower 212 moves in the horizontal section of the guide groove 221, and the driving arm 21 synchronously performs horizontal entry displacement with the driving block 243. The end of the heating component 213 is extended into the driving groove and pushes against the vertical surface in the driving groove to drive the hot cover (heating seat 11) to enter horizontally. Displacement; when the driving arm 21 drives the hot cover to the preset position, so that the cover assembly is vertically aligned with the reaction hole, the cam follower 212 enters the vertical section of the guide groove 221, and the driving arm 21 performs vertical downward displacement with the driving block 243. At the same time, it pushes against the horizontal lower surface in the driving groove (the upper surface of the cover assembly) to drive the hot cover (heating seat 11) to move vertically downward until the cover assembly 12 completely closes the reaction hole 3, so that the hot cover is kept in the hot cover closed position. When the heating process is finished, according to the control instruction, the driving motor 23 rotates in the opposite direction to drive the driving block 243 to withdraw horizontally. At this time, the cam follower 212 moves in the vertical section of the guide groove 221, and the driving arm 21 performs vertical upward displacement with the horizontal withdrawal displacement of the driving block 243, and at the same time pushes against the horizontal upper surface in the driving groove to drive the heat cover (heating seat 11) to move vertically upward until the cover body assembly 12 is completely separated from the reaction hole 3; when the cam follower 212 enters the horizontal section of the guide groove 221, the driving arm 21 performs horizontal withdrawal displacement synchronously with the driving block 243, and at the same time, the heat cover returns to the heat cover opening position driven by the reset force of the elastic sealing member 13.

[0047] Through the above preferred embodiment, it is possible to use a single motor to drive the heat cover to move horizontally and vertically. Figures 1 to 7 The specific structure shown is only a schematic structure for technicians to understand the technical solution of the present invention. When applying the present invention, those skilled in the art can select any suitable driving structure to achieve horizontal and vertical displacement of the heat cover according to needs.

[0048] The above is only a preferred specific embodiment of the present invention, but the protection scope of the present invention is not limited thereto. Any changes or substitutions that can be easily thought of by a person skilled in the art within the technical scope disclosed by the present invention should be included in the protection scope of the present invention. Therefore, the protection scope of the present invention should be based on the protection scope of the claims.

Claims

1. A two-way displacement fully sealed thermal cover system, characterized in that: It includes a thermal cover and a displacement drive module that are not fixedly connected to each other; The heat cover is sealed and arranged on the wall of the cartridge by an elastic seal member so as to be able to move in and out horizontally and / or move up and down vertically, and the heat cover is kept horizontal and faces the reaction hole to be heated; The displacement driving module is arranged outside the card box, and the displacement driving module at least drives the thermal cover to move horizontally, vertically ascend, and vertically descend; The thermal cover stays at the thermal cover open position by the elasticity of the elastic sealing member when not subjected to external force, and the thermal cover open position is a position where the thermal cover is horizontally withdrawn to a limit position and vertically ascended to a natural position without external force; the displacement driving module provides external force to drive the thermal cover to move and stay at the thermal cover closed position, and the thermal cover closed position is a position where the thermal cover is horizontally entered to a limit position and vertically descended to the limit position and covers and closes the reaction hole.

2. The system according to claim 1, characterized in that The elastic sealing member comprises an elastic member of an accordion cover structure that can be retracted and deformed, and the elastic sealing member maintains a contracted state when not acted upon by an external force and provides a force tending to return to the contracted state when stretched by an external force.

3. The system according to claim 2, characterized in that The elastic sealing element includes a silicone film or a soft rubber film.

4. The system according to claim 1, characterized in that The thermal cover comprises a heating seat and a cover assembly arranged on the bottom surface of the heating seat, and the heating seat is sealed and connected to the wall surface of the card box through the elastic sealing member so as to be horizontally movable in and out and / or vertically movable up and down; the heating seat is provided with a driving groove opening toward the external environment, and the driving groove has at least a horizontal upper surface, a horizontal lower surface formed by the upper surface of the cover assembly, and a vertical surface.

5. The system according to claim 4, characterized in that The displacement driving module includes a driving arm, the size of which corresponds to the driving slot, and the driving arm is inserted into the driving slot and pushes against the horizontal upper surface, horizontal lower surface or vertical surface in the driving slot to drive the cover body assembly to move vertically upward, vertically downward or horizontally; a heating assembly is provided at one end of the driving arm inserted into the driving slot.

6. The system according to claim 5, characterized in that The displacement driving module also includes a fixing seat fixedly arranged relative to the card box, a driving motor installed on the fixing seat, and a driving guide structure; The driving motor rotates forward and reversely according to the control instruction to provide power for driving the driving arm to move; The driving guide structure includes a lead screw driven to rotate by the driving motor and a linear guide shaft parallel to the lead screw, and a driving block installed on the lead screw and the linear guide shaft and horizontally entering and exiting displacements with the positive and reverse rotations of the lead screw; the driving block is connected to the driving arm through a connecting rod; a guide groove is also provided on the fixed seat, and the driving arm is also fixedly connected to a cam follower, which is installed in the guide groove on the fixed seat and limits the displacement of the driving arm along the guide groove; the guide groove includes a connected horizontal section and a vertical section, and the cam follower is horizontally displaced through the horizontal section and then vertically displaced downward through the vertical section.

7. The system according to claim 6, characterized in that Two parallel connecting rods are respectively arranged on both sides of the driving block to connect the driving arms.

8. The system according to claim 6, characterized in that A guide protrusion is provided at the connection position between the horizontal section and the vertical section of the guide groove, and the cam follower is displaced vertically upward via the guide protrusion.

9. The system according to claim 6, characterized in that The driving guide structure also includes a sliding block slidably mounted on the lead screw and the linear guide shaft, and the sliding block includes a horizontal slide seat and a vertical guide rail fixedly connected to each other; the sliding block and the end of the driving arm away from the thermal cover are connected through the vertical guide rail and limit the sliding block and the driving arm to only be able to perform relative displacement in the vertical up and down directions.

10. The system according to claim 9, characterized in that The horizontal slide is fixedly provided with a guide rod penetrating the driving arm, and the sliding block and the driving arm are connected through a vertical guide rail and the guide rod limits the relative displacement between them in the vertical up-and-down direction only; A pre-compression spring is sleeved on the guide rod. The pre-compression spring is located between the horizontal slide and the driving arm and provides a force to drive the horizontal slide and the driving arm to move vertically away from each other.

11. The system according to any one of claims 5 to 10, characterized in that: The heating component includes a PI heating film, a ceramic heating sheet, a Peltier, a silica gel heating sheet or a mica heating sheet.

12. The system according to any one of claims 5 to 10, characterized in that The heating component is also provided with a temperature sensor.

13. A two-way displacement fully sealed heat cover driving method, characterized in that: A single drive motor is used to drive the heat cover to perform horizontal displacement and vertical displacement in sequence to complete the heat cover closing displacement operation or the heat cover opening displacement operation. The method is used to implement the system described in any one of claims 1 to 12.

14. The method according to claim 13, characterized in that The heat cover closing displacement operation includes driving the motor to rotate forward to drive the heat cover to move horizontally to the top of the reaction hole, and then move vertically downward to cover and press the reaction hole; the heat cover opening displacement operation includes driving the motor to rotate backward to drive the heat cover to move vertically upward to release the reaction hole, and then the force of the elastic sealing member tending to return to the contracted state drives the heat cover to move horizontally out of the space above the reaction hole.

15. The method according to claim 14, characterized in that The heat cover closing displacement operation includes the following steps: the driving motor rotates forward to drive the driving arm to push the heat cover horizontally to move to the top of the reaction hole, and then continue to push the heat cover vertically downward to cover and compact the reaction hole; the heat cover opening displacement operation includes the driving motor rotates reversely to drive the driving arm to push the heat cover vertically upward to release the reaction hole, and then exit horizontally to disengage from the contact with the heat cover.

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