Analysis method, analysis device and computer readable medium

Abstract

The analysis method of the present invention is an analysis method for performing an analysis related to the concentration of the first substance on a sample containing a first substance and a second substance that affects the analysis of the first substance, and comprises the following steps: performing an analysis related to the concentration of the first substance on the sample to obtain sample analysis data; and deriving an analysis result related to the concentration of the first substance based on the sample analysis data and adjustment information based on an influence setting.

Description

Technical Field

[0001] The present invention relates to an analysis method, an analysis device and a computer-readable medium. Background Art

[0002] When analyzing the concentration and mass of an analyte contained in a sample by gas chromatography (GC) or gas chromatography-mass spectrometer (GC-MS), the concentration or mass of the analyte contained in the sample may not be correctly analyzed because the sample contains substances different from the analyte.

[0003] For example, it is known that due to the ionization suppression effect of a substance contained as an impurity in a sample, the detection signal intensity related to the concentration and mass of the analyte becomes smaller than the signal intensity that should be detected (for example, refer to Non-Patent Document 1). On the other hand, in the case where the impurity has an ionization boosting effect, it is considered that the detection signal intensity of the analyte component becomes larger than the signal intensity that should be detected.

[0004] In addition, the detection signal intensity of the analyte contained in the sample is sometimes affected by the base material of the sample. For example, it is known that when the concentration and mass of bromine flame retardants (e.g., decabromodiphenylether (Deca-BDE)) contained in polyvinyl chloride resin (PVC) are analyzed using pyrolysis gas chromatography-mass spectrometry (Py-GC / MS), the signal intensity corresponding to Deca-BDE becomes smaller than when Deca-BDE is contained in a resin other than PVC (e.g., polystyrene). It is speculated that this is because a reaction occurs in which the bromine constituting Deca-BDE exchanges with the chlorine constituting PVC, and thus the signal intensity corresponding to Deca-BDE becomes smaller than the original intensity. (For example, refer to non-patent document 2).

[0005] In such a case, the following steps are adopted: preparing a plurality of reference samples containing the same substance as the sample to be analyzed but containing the component to be analyzed at different concentrations, obtaining a calibration curve based on a plurality of signal intensities corresponding to the component to be analyzed obtained by analyzing these reference samples, and applying the signal intensities obtained by analyzing the sample to be analyzed to the calibration curve, thereby more accurately analyzing the concentration and mass of the substance to be analyzed in the sample to be analyzed, etc. However, since such steps are complicated, they require effort and time, and thus there is a problem of increased analysis cost.

[0006] Prior art literature

[0007] Non-patent literature

[0008] Non-patent document 1: Antignac et al., "The ion suppression phenomenon in liquid chromatography-mass spectrometry and its consequences in the field of residue analysis", Analytica Chimica Acta Vol. 529 pp129-136, (2005)

[0009] Non-patent document 2: Thoma et al., "PVC-INDUCED CHLORINE-BROMINE EXCHANGE IN THE PYROLYSIS OF POLYBROMINATED DIPHENYL ETHERS, -BIPHENYLS, -DIBENZODIOXINS AND DIBENZOFURANS (PVC-induced chlorine-bromine exchange in the thermal decomposition of polybrominated diphenyl ethers, -biphenyl, -dibenzo-p-dioxins and dibenzofurans)", Chemosphere, Vol. 16, No. 1, pp 297-307, (1987) Summary of the invention

[0010] Technical problem to be solved by the invention

[0011] For a sample containing an influencing substance (second substance) that influences analysis of an analyte (first substance), analysis related to the concentration (content) and mass of the analyte (first substance) is accurately and efficiently performed.

[0012] Solutions for solving the above technical problems

[0013] The first scheme of the present invention relates to an analysis method for performing an analysis related to the concentration of the first substance on a sample containing a first substance and a second substance that influences the analysis of the first substance, the analysis method comprising: performing an analysis related to the concentration of the first substance on the sample to obtain sample analysis data; and deriving an analysis result related to the concentration of the first substance based on the sample analysis data and adjustment information set based on the influence.

[0014] A second embodiment of the present invention relates to an analysis device that performs analysis related to the concentration of the first substance on a sample containing a first substance and a second substance that influences the analysis of the first substance, the analysis device comprising a processing device that derives an analysis result related to the concentration of the first substance based on sample analysis data obtained by analyzing the sample related to the concentration of the first substance and adjustment information set based on the influence.

[0015] The third scheme of the present invention relates to a computer-readable medium (Non-transitory computerreadable medium), which stores a program for causing a processing device to perform an analytical processing related to the concentration of the first substance, wherein the analytical processing is performed on a sample containing the first substance and a second substance that affects the analysis of the first substance, and the program derives an analysis result related to the concentration of the first substance based on sample analysis data obtained by analyzing the sample related to the concentration of the first substance and adjustment information set based on the influence during the analytical processing.

[0016] Effects of the Invention

[0017] According to the present invention, analysis related to the concentration and mass of an analyte (first substance) can be accurately and efficiently performed on a sample containing an influencing substance (second substance) that influences analysis of the analyte (first substance). BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 This is a conceptual diagram showing the configuration of an analysis device according to one embodiment.

[0019] Figure 2 This is a graph showing a reference peak corresponding to Deca-BDE in a reference sample.

[0020] Figure 3 This is a graph showing a reference peak corresponding to Deca-BDE in a reference sample.

[0021] Figure 4 is a conceptual diagram showing a reference calibration curve and an adjustment calibration curve.

[0022] Figure 5 This is a table showing examples of threshold values ​​used in evaluation.

[0023] Figure 6 This is a table showing examples of threshold values ​​used in evaluation.

[0024] Figure 7 This is a flowchart showing the flow of an analysis method according to one embodiment.

[0025] Figure 8 This is a conceptual diagram for explaining provision of a program. DETAILED DESCRIPTION

[0026] In the following embodiments, a first substance to be analyzed contained in a sample is appropriately referred to as an analysis target substance, and a second substance that affects the analysis of the analysis target substance (first substance) is appropriately referred to as an influencing substance.

[0027] - Implementation Method -

[0028] <About the sample>

[0029] The sample containing both the analyte and the influencing substance is not particularly limited. For example, the sample may be composed of the influencing substance as its matrix, or may be composed of the influencing substance independently of the matrix. There is no particular limitation on the types of the analyte and the influencing substance. The sample may be any of solid, liquid and gas.

[0030] When the base material of the sample is unknown, the type of base material of the sample is determined by analysis. As the analysis method, various analysis methods described below can be used. For example, Figure 1 Alternatively, a Fourier transform infrared spectrophotometer (FTIR) may be used. In addition, when the type of the base material of the sample is known, the above analysis may be performed to determine whether the base material has been correctly identified.

[0031] Examples of the substances to be analyzed include polybrominated diphenyl ethers (PBDEs). ethers), such as Decabromodiphenylether (Deca-BDE), Pentabromodiphenylether, Hexabromodiphenylether, Octabromodiphenylether, etc.; or polybrominated biphenyls (PBBs), such as Decabromobiphenyl, Tetrabromobisphenol A (TBBPA), Hexabromocyclododecane (HBCD); phthalates, such as Di (2-ethylhexyl) phthalate (DEHP), Di-n-butyl phthalate (DBP), n-butyl benzyl phthalate (BBP), Diisononyl phthalate (DINP), Di-isodecyl phthalate (DIDP), Di-n-octyl phthalate (DNOP), etc.

[0032] Brominated compounds are used as flame retardants for resin materials, and phthalates are used as plasticizers for resin materials. However, due to their adverse effects on living organisms, there is a tendency for restrictions to be strengthened. Therefore, in order to manage products containing these substances, etc., the importance of efficient analysis and evaluation has increased.

[0033] Examples of the influencing substance (second substance) contained in the sample include compounds containing chlorine, such as polyvinyl chloride (PVC), etc. Hereinafter, chlorine and bromine refer to elements rather than molecules unless otherwise specified.

[0034] <About Analysis>

[0035] The sample is analyzed to obtain analytical data related to the concentration (content) of the analyte contained in the sample. As analytical data, it is preferred to detect the signal intensity (peak) corresponding to the analyte. In this specification, the analytical data obtained by analyzing the sample is referred to as sample analysis data. Sample analysis data is data obtained under the influence of an influencing substance. Based on the influence of the influencing substance on the sample analysis data, information for obtaining a correct analysis result is generated. This information is referred to as adjustment information in this specification. Based on the sample analysis data and the adjustment information, an analytical result related to the concentration of the analyte is derived. Thus, a correct analysis result related to the concentration of the analyte can be obtained.

[0036] The analysis method is not particularly limited as long as quantitative analysis can be performed. For example, at least one of gas chromatography, liquid chromatography, mass spectrometry (Mass Spectrometry; MS), gas chromatography-mass spectrometry (Gas Chromatography / Mass Spectrometry; hereinafter referred to as GC / MS), pyrolysis gas chromatography / mass spectrometry (Pyrolysis GC / MS; hereinafter referred to as Py-GC / MS), liquid chromatography / mass spectrometry (hereinafter referred to as LC / MS), Fourier transform infrared spectroscopy, and spectrophotometry using ultraviolet-visible light can be used.

[0037] <About Reference Sample>

[0038] The reference sample is a sample that contains the analyte and does not contain any influencing substance that affects the analysis of the analyte. The reference sample is not particularly limited as long as it can accurately and stably analyze the analyte.

[0039] <About calculation of concentration (content ratio)>

[0040] The concentration of the analyte is determined based on the signal intensity of the analyte obtained by analyzing the sample and the reference sample.

[0041] <About substance information related to the first substance and the second substance>

[0042] When the analysis data corresponding to the analyte (first substance) obtained by analyzing the sample is different from the analysis data that should have been obtained, the sample is deemed to contain an influencing substance (second substance) that affects the analysis of the analyte (first substance). For example, when the concentration of the first substance obtained by analyzing a sample whose concentration of the analyte is known is different from the known concentration, the sample is deemed to contain a second substance that affects the analysis of the first substance.

[0043] The influencing substance may or may not be determined. For example, when the analyte is brominated diphenyl ether (e.g., Deca-BDE), in the Py-GC / MS analysis, PVC is determined as the influencing substance that exerts an influence on the analysis of Deca-BDE. In this case, the first substance and the second substance are set. On the other hand, in the case of analyzing a certain analyte, although the influencing substance cannot be determined, when it is known that the analysis result is different from the result that should be obtained, only the analyte (the first substance) is set. On the contrary, in a sample having a certain base material, when it is known that the analysis result is different from the result that should be obtained regardless of the contained substances other than the base material, the influencing substance (the second substance) is set to the substance of the base material.

[0044] Information on the first substance and the second substance (referred to as substance information) may be input into the analyzer by an operator during analysis, or the substance information may be stored in a storage unit of the analyzer and automatically read out during analysis.

[0045] <About adjustment information>

[0046] The adjustment information is information used to adjust the analysis data and the threshold value used for evaluation to obtain a correct analysis result when at least one of the first substance and the second substance is set. The form and generation procedure of the adjustment information are not limited. For example, the adjustment information can be generated as follows. In addition, the adjustment information can be input into the analysis device by an operator, or it can be set to correspond to the information related to the combination of the first substance and the second substance, and stored in advance in the storage unit of the analysis device, and automatically read out.

[0047] 1. Analysis of reference samples

[0048] Prepare a reference sample in which the concentration of the analyte (first substance) is known and which contains an influencing substance (second substance). The composition of the reference sample is the same as that of the analyte except that the concentration of the substance other than the analyte is known. Analyze the reference sample to obtain a signal intensity (referred to as a reference peak) corresponding to the analyte. For example, when the concentration of Deca-BDE, which is the analyte contained in a PVC matrix material, which is an influencing substance, is set as the analyte, prepare PVC containing Deca-BDE at a known concentration as a reference sample. Analyze the reference sample to obtain a reference peak corresponding to the known concentration of Deca-BDE.

[0049] 2. Analysis of reference samples

[0050] A plurality of reference samples are prepared which contain the same type of analyte as the reference sample at the same concentration as the reference sample and do not contain the influencing substance. For example, polystyrene containing Deca-BDE at the same concentration as the reference sample is prepared as a reference sample. The reference sample is analyzed to obtain a signal intensity (referred to as a reference peak) corresponding to the analyte. In addition, the analysis conditions of the reference sample are set to the same conditions as the analysis conditions of the reference sample.

[0051] 3. Adjust the generation of information

[0052] When the reference sample is PVC containing Deca-BDE at a known concentration and the reference sample is polystyrene containing Deca-BDE at the same concentration as the reference sample, as described above, the size of the reference peak is smaller than the size of the reference peak. Adjustment information is generated based on the reference peak and the reference peak of different sizes. For example, the peak intensity ratio, i.e., the value of the reference peak intensity / reference peak intensity, can be set as adjustment information. Alternatively, the peak area ratio, i.e., the value of the reference peak area / reference peak area, can be set as adjustment information.

[0053] 4. Generation of reference calibration curve

[0054] Prepare a plurality of auxiliary reference samples which are composed of the same type of material as the reference sample except that the concentration of the analyte is different from that of the reference sample, and the concentrations of the analyte are different from each other. That is, the auxiliary reference samples are constituted so that the concentration of the analyte is different from that of the reference sample. These auxiliary reference samples are analyzed separately to obtain a plurality of signal intensities (referred to as auxiliary reference peaks) corresponding to the analyte. The analysis conditions of the auxiliary reference samples are set to be the same as those of the baseline sample and the reference sample. For example, prepare two auxiliary reference samples, namely, polystyrene containing Deca-BDE at a lower concentration than the reference sample, and polystyrene containing Deca-BDE at a higher concentration than the reference sample. Analyze these auxiliary reference samples to obtain two auxiliary reference peaks corresponding to Deca-BDE.

[0055] Based on the size (peak intensity or peak area) of the reference peak and the plurality of auxiliary reference peaks, a reference calibration curve is generated for the concentration of the analyte. For example, the peak area of ​​the signal intensity corresponding to the analyte is set as the horizontal axis, and the concentration of the analyte is set as the vertical axis. The reference calibration curve is generated by plotting the concentration of the analyte corresponding to the reference peak area and the plurality of auxiliary reference peak areas. In addition, the reference calibration curve can also be generated in advance and stored in the storage unit 43 in advance.

[0056] 5. Adjustment of the calibration curve generation

[0057] The reference calibration curve is adjusted based on the above adjustment information to generate an adjusted calibration curve. The adjustment steps are not particularly limited. For example, the calibration curve changed to a new slope is set as an adjusted calibration curve, and the new slope is obtained by multiplying the slope of the reference calibration curve obtained by the above steps by the value of the reference peak area / reference peak area, that is, the peak area ratio. In the case where the analyte is Deca-BDE, since the size of the reference peak is smaller than the size of the reference peak, the peak area ratio becomes a value less than 1. Thus, the slope of the adjusted calibration curve is smaller than the slope of the reference calibration curve. That is, when an arbitrary peak area value is applied to the adjusted calibration curve, a larger concentration is shown compared to the case where the same value is applied to the reference calibration curve. That is, by applying the adjusted calibration curve, the influence of the influencing substance on the analysis of the analyte is corrected.

[0058] 6. Analysis of samples

[0059] An analysis is performed on the sample to be analyzed, and a signal intensity (called an analysis peak) corresponding to the analysis target substance (the first substance) is obtained. The analysis conditions of the sample are set to the same conditions as the analysis conditions of the reference sample. The area of ​​the analysis peak, i.e., the analysis peak area, is obtained and applied to the above-mentioned adjustment calibration curve. The adjustment calibration curve is used to adjust the reference calibration curve based on the adjustment information. As described above, the adjustment information is information used to correct the influence of the influencing substance on the sample analysis data to obtain a correct analysis result. That is, by using the adjustment calibration curve, a correct analysis result that corrects the influence of the influencing substance on the sample analysis data can be obtained.

[0060] The adjustment calibration curve can be generated by storing the pre-generated data in the storage unit of the analysis device and reading it out for use. However, by analyzing the reference sample and the auxiliary reference sample under the same analysis conditions as the analysis conditions of the analysis target sample immediately before or after the analysis of the analysis target sample, and using the data for generation, it is expected that more accurate analysis results can be obtained.

[0061] <About the analysis device>

[0062] The analysis device according to the present embodiment will be described with reference to the drawings. Figure 1 1 is a conceptual diagram showing the structure of the analysis device of the present embodiment. The analysis device 1 is a pyrolysis gas chromatograph-mass spectrometer (hereinafter referred to as the device 1 or Py-GCMS), and includes a measurement unit 100 and an information processing unit 40. The measurement unit 100 includes a pyrolysis gas chromatograph 10 and a mass spectrometer 30.

[0063] In addition, the analytical device of the present embodiment is not particularly limited as long as it can perform quantitative analysis. As the analytical device, a gas chromatograph (GC), a liquid chromatograph (LC), a mass spectrometer, a gas chromatograph-mass spectrometer (GC-MS), a liquid chromatograph-mass spectrometer (LC-MS), a Fourier transform infrared spectrophotometer, and a UV-visible spectrophotometer can be used.

[0064] The pyrolysis gas chromatograph 10 includes a pyrolysis device 20, a carrier gas flow path 11, a sample introduction section 12 for introducing a sample, a standard sample, a reference sample, and an auxiliary reference sample (hereinafter collectively referred to as a sample, etc.) pyrolyzed by the pyrolysis device 20, a column temperature adjustment section 13, a separation column 14, and a sample gas introduction pipe 15. The mass spectrometer 30 includes a vacuum container 31, an exhaust port 32, an ionization section 33 for plasmatizing a sample to generate ions In, an ion adjustment section 34, a mass separation section 35, and a detection section 36.

[0065] The information processing unit 40 includes an input unit 41, a communication unit 42, a storage unit 43, an output unit 44, and a control unit 50. The control unit 50 includes a device control unit 51, a data processing unit 52, and an output control unit 53. The data processing unit 52 includes a concentration calculation unit 521 and an information generation unit 522. The output control unit 53 includes a notification unit 530. The information generation unit 522 includes a determination unit 523. The measurement unit 100 separates each component of a sample, etc., by analysis, and detects the sample, etc.

[0066] The pyrolysis gas chromatograph 10 pyrolyzes a sample etc. and separates the components contained in the sample etc. based on physical or chemical properties. When introduced into the separation column 14, the sample etc. becomes a gas or a gaseous state. This is referred to as a sample gas.

[0067] The carrier gas flow path 11 is a flow path for a carrier gas such as helium, and the carrier gas is introduced into the thermal decomposition device 20 (arrow A1) through the carrier gas flow path 11. The thermal decomposition device 20 thermally decomposes the sample and introduces it into the sample introduction part 12. The type of the thermal decomposition device 20 is not particularly limited, and it can be a heating furnace type, an induction heating type, or a heating wire type. The sample introduction part 12 has a part for introducing the sample and the like and a split vent, etc., and appropriately and selectively introduces the sample gas into the separation column 14.

[0068] The separation column 14 includes a column such as a capillary column. The separation column 14 is temperature-controlled to a temperature of several hundred degrees Celsius or less by a column temperature control unit 13 including a column oven or the like. The components of the sample gas are separated based on the distribution coefficient between the mobile phase and the stationary phase of the separation column 14, and the separated components of the sample gas elute from the separation column 14 with a time difference and are introduced into the ionization unit 33 of the mass spectrometer 30 through the sample gas introduction pipe 15.

[0069] The mass spectrometer 30 includes a mass analyzer, which plasmatizes the sample introduced into the ionization unit 33, performs mass separation and detection. The path of the ions In generated in the ionization unit 33 is schematically shown by arrow A2. The ions In can include ions formed by the sample and the like combined with electrons, atoms or atomic groups, or ions generated by decomposition of the sample and the like such as dissociation, etc., which are from the sample and the like.

[0070] In addition, as long as the ions In can be detected by mass analysis with desired accuracy, the type of mass analyzer constituting the mass spectrometry unit 30 is not particularly limited, and a device including one or more mass analyzers of any type can be used.

[0071] The vacuum container 31 of the mass spectrometer 30 has an exhaust port 32. The exhaust port 32 is connected to a pump including, for example, a turbomolecular pump and an auxiliary pump thereof, which can realize 10 -2 A vacuum exhaust system (not shown) with a high vacuum of less than Pa is connected. Figure 1 In FIG. 1 , the exhaust of the gas inside the vacuum container 31 is schematically shown by arrow A3 .

[0072] The ionization unit 33 of the mass spectrometer 30 includes an ion source, and the sample introduced into the ionization unit 33 is ionized by electron ionization. Since the sample is dissociated during electron ionization, the ions In include fragment ions obtained by the dissociation of the sample. The ions In generated in the ionization unit 33 are introduced into the ion adjustment unit 34.

[0073] The ionization method of the ionization unit 33 is not particularly limited as long as it can perform ionization with desired efficiency. In the case of GC / MS, chemical ionization or the like can be used. In the case of LC / MS, an electrospray method or the like can also be used as appropriate.

[0074] The ion adjustment unit 34 of the mass spectrometer 30 includes a lens electrode and an ion guide plasma transport system, and adjusts the flow of ions In by converging the flow of ions In through electromagnetic action, etc. The ions In emitted from the ion adjustment unit 34 are introduced into the mass separation unit 35 .

[0075] The mass separation unit 35 of the mass spectrometer 30 includes a quadrupole mass filter and performs mass separation on the introduced ions In. The mass separation unit 35 selectively passes the ions In according to the m / z value by applying a voltage to the quadrupole mass filter. The ions In mass-separated in the mass separation unit 35 are incident on the detection unit 36 ​​.

[0076] The detection unit 36 ​​of the mass spectrometer 30 includes an ion detector and detects the incident ions In. The detection unit 36 ​​performs A / D conversion on the detection signal obtained by detecting the incident ions In using an A / D converter (not shown), and outputs the digitized detection signal as measurement data to the information processing unit 40 (arrow A4).

[0077] The information processing unit 40 includes an information processing device such as an electronic computer, and in addition to being an interactive interface with the operator of the analysis device 1, it also performs communication, storage, calculation and other processing related to various data. In addition, part of the data used by the analysis device 1 may be stored in a remote server, etc., and part of the calculation processing performed by the analysis device 1 may also be performed by a remote server, etc.

[0078] The input unit 41 is configured to include an input device such as a mouse, a keyboard, various buttons or a touch panel. The input unit 41 receives information required for the control of the measurement unit 100 and the processing of the control unit 50 from the operator. In addition, information related to the m / z of the ion In used for detection is also input via the input unit 41. The communication unit 42 is configured to include a communication device capable of wireless or wired communication based on the Internet, etc., and appropriately sends and receives data related to the control of the measurement unit 100 and the processing of the control unit 50.

[0079] The storage unit 43 is composed of a non-volatile storage medium, and stores measurement data (e.g., signal strength), a program for the control unit 50 to execute processing, data required for processing by the data processing unit 52, and data obtained by the processing, etc. The storage unit 43 stores setting information on the first substance and the second substance, adjustment information, information related to the reference calibration curve and / or the adjustment calibration curve, information related to the threshold value, and information related to the concentration of the sample, etc.

[0080] The output unit 44 is configured to include a display device such as a liquid crystal display, a printer, etc. The output unit 44 outputs the data obtained by the processing of the data processing unit 52 to the display device and to the printer.

[0081] The control unit 50 includes a processor such as a CPU, and performs control of the operation of each unit of the measurement unit 100, processing of measurement data, etc. The device control unit 51 of the control unit 50 controls the operation of each unit of the measurement unit 100. For example, the device control unit 51 can detect ions In by a scanning mode that continuously changes the m / z of ions passing through the mass separation unit 35 and a SIM (Selective Ion Monitoring) mode that allows multiple ions with specific m / z to pass. In this case, the device control unit 51 changes the voltage of the mass separation unit 35 so that ions In with m / z set based on input from the input unit 41, etc. selectively pass through the mass separation unit 35. The data processing unit 52 of the control unit 50 processes and analyzes the measurement data.

[0082] The concentration calculation unit 521 calculates the signal intensity of the analysis object substance based on the measurement data. The concentration calculation unit 521 generates data corresponding to the mass chromatogram (referred to as "mass chromatogram data") based on the measurement data. The mass chromatogram is a chart showing the retention time on the horizontal axis and the signal intensity of the detected ions on the vertical axis, and the same is true in the following figures. The concentration calculation unit 521 calculates the peak intensity or peak area value of the peak of the signal intensity corresponding to the analysis object substance, and further, the calculated peak intensity or peak area is applied to the reference calibration curve or the adjustment calibration curve to calculate the concentration of the analysis object substance. In addition, as long as the magnitude of the signal intensity corresponding to the analysis object substance can be quantified based on the measurement data, it is not particularly limited to the peak intensity and peak area. In addition, the concentration of the detection object substance is not particularly limited to calculation based on the reference calibration curve and the adjustment calibration curve.

[0083] The information generating unit 522 generates adjustment information based on the concentration, peak intensity, or peak area of ​​the analyte calculated by the concentration calculating unit 521. In addition, the determining unit 523 of the information generating unit 522 determines the sample based on the concentration, peak intensity, or peak area of ​​the analyte calculated by the concentration calculating unit 521. Specifically, the determination target data such as the concentration, peak intensity, or peak area of ​​the analyte is compared with the threshold value for determination stored in the storage unit 43, and the magnitude of the determination target data relative to the threshold value is determined.

[0084] In addition to the above determination, the determination unit 523 may also determine whether the analyte contained in the sample and other contained substances correspond to the first substance and the second substance, respectively. That is, the determination unit 523 may also determine whether the combination of the analyte contained in the sample and other contained substances input by the operator corresponds to any one of the information related to the combination of the first substance and the second substance stored in the storage unit 43.

[0085] The information generation unit 522 generates information based on the determination result of the determination unit 523. The output control unit 53 generates an image including analysis information and the like based on the information generated by the information generation unit 522, and controls the output unit 44 to output the image.

[0086] The notification unit 530 of the output control unit 53 outputs at least part of the analysis information to the operator. The notification method of the notification unit 530 is not particularly limited, and the notification may be performed by displaying a pop-up message on the screen of the output unit 44 or by lighting a lighting device such as a lamp (not shown).

[0087] As the notification content, for example, when the calculated concentration, peak intensity or peak area of ​​the analyte in the sample exceeds a threshold value, it can be notified that the concentration of the analyte is higher than the specified value. In addition, it can be notified that the sample contains an influencing substance (second substance) that affects the analysis of the analyte (first substance). Furthermore, it can be notified that the content of the application adjustment information and the adjustment of the calibration curve.

[0088] Next, adjustment examples will be described with reference to the drawings.

[0089] <Adjustment Example 1>

[0090] In this adjustment example, a sample containing Deca-BDE and whose base material is PVC (polyvinyl chloride) is used as an example. The analyte in the sample is Deca-BDE. Figure 1 The analysis device 1 is shown.

[0091] 1. Input of substance information

[0092] The operator inputs the name or symbol of Deca-BDE as the substance to be analyzed, and inputs the name or symbol of PVC as a contained substance other than the substance to be analyzed, through the input unit 41 of the analyzer 1. In addition, the names or symbols of all contained substances other than the substance to be analyzed are input except for the base material. The determination unit 523 of the analyzer 1 determines whether the substance input by the operator matches the first substance and / or the second substance based on the information related to the combination of the first substance and the second substance stored in the storage unit 43 (also called a substance database). When the result of the determination is that it matches, the information generation unit 522 generates an image to that effect, and controls the output unit 44 to cause the notification unit 530 to output the image.

[0093] Furthermore, when it is known that the analysis of the analyte in the sample is affected by other contained substances, although not stored in the storage unit 43 , the operator can input information about these combinations through the input unit 41 and store it in the storage unit 43 as new substance information.

[0094] In the case where the substances contained in the sample are not known, first, the substances contained in the sample are determined, and then the names or symbols of these substances are input into the input unit 41. The substances can be determined using a qualitative analysis device such as a Fourier transform infrared spectrophotometer. In this case, the input of the name or symbol of the substance can be performed manually by an operator, or can be automatically input into the storage unit 43 from the qualitative analysis device.

[0095] 2. Analysis of reference samples

[0096] As a reference sample, a sample whose base material is PVC (polyvinyl chloride) and contains Deca-BDE as the analyte at a concentration of 2000 mg / kg is prepared. That is, the reference sample is composed of the same substance as the sample except that the concentration of Deca-BDE as the analyte is known.

[0097] The reference sample is analyzed by the analyzer 1 to generate a mass spectrum of the reference sample. The determination unit 523 selects a peak corresponding to Deca-BDE in the mass spectrum based on the information on the substance and the spectrum stored in the storage unit 43 .

[0098] Figure 2 The reference peak corresponding to Deca-BDE in the reference sample obtained by the above steps is shown. Figure 2 In the figure, the horizontal axis represents the holding time and the vertical axis represents the signal strength. Figure 2 The two peaks shown show signals corresponding to the fragment ions obtained by analyzing the two fragment ions. The peak area of ​​the peak corresponding to Deca-BDE, that is, the reference peak area, is calculated by the concentration calculation unit 521 and stored in the storage unit 43. The calculated reference peak area is 1102035 (counts).

[0099] 3. Analysis of reference samples

[0100] As a reference sample, a sample containing Deca-BDE at a concentration of 2000 mg / kg using polystyrene as a matrix was prepared. That is, the reference sample contained Deca-BDE as an analyte at the same concentration as the standard sample, and the matrix was composed of polystyrene which did not affect the analysis of Deca-BDE.

[0101] The reference sample is analyzed by the analyzer 1 to generate a mass spectrum of the reference sample. The determination unit 523 selects a peak corresponding to Deca-BDE in the mass spectrum based on the information on the substance and the spectrum stored in the storage unit 43 .

[0102] Figure 3 The reference peak corresponding to Deca-BDE in the reference sample obtained by the above steps is shown. Figure 3 In the figure, the horizontal axis represents the holding time and the vertical axis represents the signal strength. Figure 3 The two peaks shown show signals corresponding to the fragment ions obtained by analyzing the two fragment ions. These fragment ions are the same as those used in the analysis of the reference sample. The peak area, i.e., the reference peak area, of the peak corresponding to Deca-BDE is calculated by the concentration calculation unit 521 and stored in the storage unit 43. The calculated reference peak area is 1937409 (counts).

[0103] 4. Calculation of adjustment information

[0104] The information generating unit 522 calculates the value of the peak area ratio = the reference peak area / the reference peak area based on the reference peak area and the reference peak area calculated by the concentration generating unit 521, and stores it as the adjustment information in the storage unit 43. In this adjustment example, 0.57 is stored in the storage unit 43 as the adjustment information based on 1102035 / 1937409=0.57.

[0105] 5. Generation of reference calibration curve

[0106] Two auxiliary reference samples were prepared, each of which was made of polystyrene and contained Deca-BDE at two concentrations of 1000 mg / kg and 3000 mg / kg, respectively.

[0107] The auxiliary reference samples are analyzed by the analysis device 1 to generate a mass spectrum of the auxiliary reference sample. The determination unit 523 selects the peak corresponding to Deca-BDE in the mass spectrum based on the information related to the substance and the spectrum stored in the storage unit 43. The peak area of ​​the peak corresponding to Deca-BDE, that is, the two auxiliary reference peak areas, is calculated by the concentration calculation unit 521 and stored in the storage unit 43.

[0108] The data processing unit 52 generates a reference calibration curve for Deca-BDE concentration using the reference peak area and the two auxiliary reference peak areas, and displays it on the notification unit of the output control unit 53. Figure 4 The reference calibration curve generated by the above steps is shown by a dotted line in FIG.

[0109] 6. Adjustment of the calibration curve generation

[0110] The data processing unit 52 reads the adjustment information stored in the storage unit 43, adjusts the reference calibration curve using the adjustment information, and generates an adjustment calibration curve. For example, an adjustment calibration curve is generated by multiplying the slope (differential coefficient) of the reference calibration curve by 0.57 as the adjustment information as a new slope. Figure 4 The adjusted calibration curve generated by the above steps is shown by a solid line in FIG. The adjusted calibration curve is a calibration curve used for analysis of a sample.

[0111] 7. Analysis of samples

[0112] The sample is analyzed by the analyzer 1 to generate a mass spectrum of the sample. The determination unit 523 selects the peak corresponding to Deca-BDE in the mass spectrum based on the information related to the substance and the spectrum stored in the storage unit 43. The concentration calculation unit 521 calculates the peak area of ​​the peak corresponding to Deca-BDE, that is, the analysis peak area, and stores it in the storage unit 43. The concentration calculation unit 521 applies the calculated analysis peak area to the adjustment calibration curve, calculates the concentration of Deca-BDE in the sample, and stores it in the storage unit 43.

[0113] Figure 4 The process of calculating the concentration of a sample is shown. For example, when the peak area (sample peak area) corresponding to Deca-BDE calculated by analyzing the sample is 1500000, this value is applied to the calibration curve to calculate the concentration of Deca-BDE to be 2722 mg / kg. Figure 4 It can be seen that if the sample peak area is not used for the adjustment calibration curve but for the reference calibration curve, the concentration of Deca-BDE is calculated to be 1548 mg / kg. This is the result of the analysis of Deca-BDE being affected by PVC, and is a value far lower than the original concentration.

[0114] According to this adjustment example, as described above, by using an adjusted calibration curve generated by adjusting the reference calibration curve based on the adjustment information, analysis related to the concentration of the first substance can be accurately and efficiently performed in a sample containing a second substance that affects the analyte (first substance).

[0115] In this adjustment example, by using the auxiliary reference sample on the basis of the reference sample, the samples of multiple concentrations including the concentration of the analyte in the reference sample are analyzed, and a reference calibration curve is generated based on the results. However, the reference calibration curve can also be generated using only the reference sample without using the auxiliary reference sample. In this case, the peak area of ​​the reference peak obtained by the analysis of the reference sample and the points plotted according to the concentration of the analyte and the straight line of the origin are used as the reference calibration curve.

[0116] In addition, there are cases where the reference calibration curve does not pass through the origin. In this case, when the concentration is set as the x-axis (horizontal axis) and the peak area is set as the y-axis (vertical axis), the reference calibration curve can be expressed as x=(yb) / a. Here, a shows the slope of the reference calibration curve, and b shows the intercept of the reference calibration curve. In this case, the adjustment calibration curve can, for example, take the product of the adjustment information (0.57 in this adjustment example) and the slope a as a', and express it as x=(yb) / a'.

[0117] The meaning of generating the adjustment calibration curve by setting the slope a of the reference calibration curve to the slope a' after being changed based on the adjustment information is explained. However, the generation of the adjustment calibration curve is not limited to this, and it can be appropriately generated based on the content of the adjustment information. For example, the reference calibration curve can be moved upward or downward to form the adjustment calibration curve. In addition, the slope of the reference calibration curve can also be locally changed, for example, to form an adjustment calibration curve of a quadratic curve.

[0118] In this adjustment example, the adjustment information, the reference calibration curve, the adjustment calibration curve, etc. are generated based on the peak area. However, they may be generated based on the peak height instead of the peak area.

[0119] In this adjustment example, the reference sample, the reference sample, and the auxiliary reference sample are analyzed respectively, and the reference calibration curve is obtained based on the obtained signal intensity, and the adjustment information is calculated. Based on the calculated adjustment information, the adjustment calibration curve is generated, and the signal intensity obtained by analyzing the sample is applied to the adjustment calibration curve to derive the analysis result. However, the reference calibration curve, the adjustment information, the auxiliary reference sample, etc. can also be stored in advance in the storage unit 43 of the analysis device 1. For example, if the sample is analyzed to generate analysis data, the analysis data can also be applied to the adjustment calibration curve stored in the storage unit 43 to obtain the analysis result.

[0120] When the base material of the sample is unknown, analysis for determining the base material of the sample is performed before generating the above-mentioned analysis data. In this case, the information generating unit 522 may also automatically generate an adjustment calibration curve based on the information (material information) about the type of the determined base material using the adjustment information pre-stored in the storage unit 43 and the reference calibration curve, and apply the adjustment calibration curve to the above-mentioned analysis data to obtain the analysis result.

[0121] In this adjustment example, the order of analysis of the base sample, analysis of the reference sample, calculation of the adjustment information, generation of the reference calibration curve, generation of the adjustment calibration curve, and analysis of the sample is described, but this order is not limited. For example, after analyzing the sample, the base sample and the reference sample may be analyzed to obtain the adjustment information, and the adjustment calibration curve may be generated based on the adjustment information.

[0122] <Adjustment Example 2>

[0123] In Adjustment Example 1, the steps of correctly determining the concentration of the analyte in the sample are described. In this adjustment example, the steps of evaluating the sample by setting a threshold value based on adjustment information relative to the concentration or signal intensity obtained by analyzing the sample are described. In this adjustment example, the adjustment calibration curve is not used.

[0124] The analysis of the standard sample, the analysis of the reference sample, the calculation of the adjustment information, and the generation of the reference calibration curve performed by the analyzer 1 are based on the procedures performed in Adjustment Example 1.

[0125] 1. Input of substance information and evaluation thresholds

[0126] The input of the substance information is performed by the steps described in Adjustment Example 1. In addition, in this adjustment example, a threshold value (referred to as an evaluation threshold value) as an evaluation index of the analysis target substance is input from the input unit 41. The input evaluation threshold value is stored in the storage unit 43 together with the substance information. In addition, the evaluation threshold value may be set in advance and stored in the storage unit 43 in advance.

[0127] 2. Adjust the threshold generation

[0128] The data processing unit 52 generates an adjustment threshold value by adjusting the evaluation threshold value based on the adjustment information. The adjustment threshold value is a threshold value set in order to correct the influence of the influencing substance in the analysis of the analysis object substance so as to correctly evaluate the analysis object substance. For example, the evaluation threshold value used for evaluating the concentration of Deca-BDE is described. As described above, the signal intensity corresponding to Deca-BDE obtained by analyzing PVC containing Deca-BDE is smaller than the signal intensity that should be obtained. That is, the concentration of Deca-BDE is evaluated based on the adjustment threshold value generated in a manner that becomes a value smaller than the evaluation threshold value. The generated adjustment threshold value is stored in the storage unit 43 as information associated with the substance.

[0129] 3. Sample Analysis

[0130] The sample is analyzed by the analysis device 1 to generate a mass spectrum of the sample. The determination unit 523 selects the peak corresponding to Deca-BDE in the mass spectrum based on the information related to the substance and the spectrum stored in the storage unit 43. The concentration calculation unit 521 calculates the peak area of ​​the peak corresponding to Deca-BDE, that is, the analysis peak area, and stores it in the storage unit 43. In this adjustment example, the concentration calculation unit 521 applies the calculated analysis peak area to the reference calibration curve to calculate the concentration of Deca-BDE in the sample. The calculated concentration is affected by PVC and is a value lower than the original concentration. In this specification, this concentration is referred to as a hypothetical concentration.

[0131] 4. Evaluation of samples

[0132] The determination unit 523 evaluates the analyte in the sample (the concentration of Deca-BDE in this adjustment example) by comparing the assumed concentration with the adjustment threshold. As described above, in this adjustment example, even if there is an influence caused by PVC, the evaluation related to the concentration of Deca-BDE in the sample can be accurately performed.

[0133] In the above description, the steps of evaluating the concentration of the analyte are described by taking a sample whose base material is PVC (polyvinyl chloride) and contains Deca-BDE as an example. According to this step, in addition to the combination of the analyte and the influencing substance of the above sample, the adjustment threshold can be set based on the adjustment information for various combinations of the analyte and the influencing substance.

[0134] exist Figure 5 The table shown shows examples of adjustment thresholds for evaluating various combination samples of the analyte and the influencing substance. Figure 5 An example of two adjustment thresholds set for three samples containing analyte substances (compounds) A, B, C, and D, respectively, is shown. The three samples correspond to a sample that does not contain an influencing substance that affects the analysis of the analyte substance, a sample that contains an influencing substance I, and a sample that contains an influencing substance II. For example, the two adjustment thresholds are set when there are three methods for handling a sample and they are set as indicators for determining which handling method to apply. That is, it is assumed that the first handling method is applied when the analyte substance is lower than threshold 1, the second handling method is applied when it is between threshold 1 and threshold 2, and the third handling method is applied when it is higher than threshold 2, etc. In addition, the threshold applied to the sample that does not contain an influencing substance is an evaluation threshold, and no adjustment based on the adjustment information is performed.

[0135] For the sample containing the influencing substance I and the sample containing the influencing substance II, the threshold 1 and the threshold 2 adjusted using the adjustment information based on the substance information of the analyte and the influencing substance are set.

[0136] exist Figure 5 In the table shown, as described above, each threshold is set individually based on the adjustment information, but each threshold can also be set based on a formula that describes the relationship between the evaluation threshold and the adjustment threshold based on the adjustment information. For example, the threshold 1 (T11) for each analyte substance of the sample containing the influencing substance I can be set to a value that is α mg / kg smaller than the evaluation threshold (threshold 1 for the sample not containing the influencing substance: T1B). That is, it can be set to T11 = T1B + α. In addition, the threshold 2 (T12) for each analyte substance of the sample containing the influencing substance I can be set to a value that is β mg / kg larger than the evaluation threshold 2 (T2B). That is, it can be set to T12 = T2B + β. In addition, the threshold 1 (T21) and the threshold 2 (T22) for each analyte substance of the sample containing the influencing substance II can be set to T21 = T1B × γ and T22 = T2B × δ, respectively. Here, each value of the coefficients α, β, γ, and δ can be appropriately set based on adjustment information, the purpose of analysis, and the like.

[0137] Figure 6 An example of the adjustment threshold value for sample evaluation set in this way is shown. Figure 6 The threshold values ​​shown are adjustment threshold values ​​set to α=-300 (mg / kg), β=300 (mg / kg), γ=0.7, and δ=1.3.

[0138] In addition, in the above description, the evaluation of the sample is generally described by comparing the concentration (assumed concentration) of the analyte with the adjustment threshold. However, even if the concentration is not required, the signal intensity obtained by the analysis can be set to a threshold. For example, the peak area or peak intensity corresponding to the analyte in the signal intensity can be obtained, and the sample can be evaluated by comparing it with the adjustment threshold set for the peak area or peak intensity based on the adjustment information.

[0139] In this adjustment example, when the base material of the sample is unknown, analysis for determining the base material of the sample is performed before the generation of the above-mentioned analysis data. In this case, the information generation unit 522 can also automatically generate an adjustment threshold based on the information (material information) on the type of the determined base material, using the adjustment information and evaluation threshold pre-stored in the storage unit 43, and apply the adjustment threshold to the above-mentioned analysis data to obtain the analysis result.

[0140] Figure 7 1 is a flowchart showing the flow of the analysis method of the present embodiment. In step S1001, the determination unit 523 determines whether the substances contained in the sample to be analyzed contain the first substance and the second substance. That is, the substance information is determined. If the result of the determination is that the first substance and the second substance are contained, a positive determination is made, and the process proceeds to step S1003. On the other hand, if the result of the determination is that the first substance and the second substance are not contained, a negative determination is made, and the process proceeds to step S1007.

[0141] In step S1003, the data processing unit 52 reads the adjustment information from the storage unit 43, and the process proceeds to step S1005. In step S1005, the concentration calculation unit 521 analyzes the sample using the adjustment information to obtain the concentration of the analyte in the sample, and the process proceeds to step S1009.

[0142] In step S1007, the concentration calculation unit 521 calculates the concentration of the analyte in the sample and proceeds to step S1009. That is, in step S1007, the adjustment information is not applied to the analysis of the sample. This is because the sample does not contain any influencing substance that affects the analysis of the sample, so there is no need to adjust the analysis data.

[0143] In step S1009, the determination unit 523 derives the analysis result and proceeds to step S1011. The analysis result is the calculation of the concentration of the analyte in the sample or the evaluation of the sample based on the calculated concentration. In step S1011, the output unit 44 outputs the analysis result, and a series of processing ends.

[0144] The following modifications are also within the scope of the present invention and can be combined with the above-described embodiment. In the following modifications, parts and the like showing the same structure and function as those in the above-described embodiment are referred to with the same reference numerals, and description thereof is appropriately omitted.

[0145] <Modification 1>

[0146] In the above-mentioned adjustment example 2, the threshold is adjusted based on the adjustment information to generate the adjusted threshold, and the sample is evaluated based on the adjusted threshold. However, the sample may be evaluated by comparing the sample concentration obtained based on the adjustment calibration curve with the evaluation threshold.

[0147] <Modification 2>

[0148] It is also possible to record the program for realizing the information processing function of the analysis device 1 on a computer-readable recording medium, so that the computer system reads and executes the program recorded on the recording medium related to the control of the processing of the above-mentioned data processing unit 52 and the processing associated therewith. In addition, the "computer system" mentioned here is set to include the hardware of OS (Operating System: operating system) and peripheral devices. In addition, the "computer-readable recording medium" refers to a removable recording medium such as a floppy disk, a magneto-optical disk, an optical disk, a memory card, and a storage device such as a hard disk built into the computer system. Furthermore, the "computer-readable recording medium" may also include a medium that dynamically maintains the program in a short time, such as a communication line in the case of sending a program via a network such as the Internet or a communication line such as a telephone line, and a medium that maintains the program for a certain period of time, such as a volatile memory inside a computer system that becomes a server or client in this case. In addition, the above-mentioned program may be a program for realizing a part of the above-mentioned function, and further, it may be a program that realizes the above-mentioned function by combining with a program already recorded in the computer system.

[0149] When applied to a personal computer (hereinafter referred to as PC) or the like, the program related to the above-mentioned control can be provided via a recording medium such as a CD-ROM or DVD-ROM or a data signal such as the Internet. Figure 8950 is a conceptual diagram showing the situation. PC950 receives the program via CD-ROM953. In addition, PC950 has a connection function with communication line 951. Computer 952 is a server computer that provides the above-mentioned program, and stores the program in a recording medium such as a hard disk. Communication line 951 is a communication line such as the Internet, personal computer communication, or a dedicated communication line. Computer 952 uses a hard disk to read the program and sends the program to PC950 via communication line 951. That is, the program is transmitted as a data signal through a carrier wave and sent via communication line 951. In this way, the program can be provided as a computer program product that can be read by a computer in various forms such as a recording medium and a carrier wave.

[0150] <Solution>

[0151] Those skilled in the art will appreciate that the above-mentioned multiple embodiments are specific examples of the following schemes.

[0152] (Item 1) An analysis method of one embodiment is an analysis method for performing analysis related to the concentration of a sample containing a first substance and a second substance that affects the analysis of the first substance, and comprises the following steps: performing analysis related to the concentration of the first substance on the sample to obtain sample analysis data; and deriving an analysis result related to the concentration of the first substance based on the sample analysis data and adjustment information set based on the influence. Thus, even when analyzing a sample containing a substance that affects the analysis of the contained analyte, the concentration and mass of the analyte contained in the analyte sample can be accurately analyzed.

[0153] (Item 2) Another analytical method is, in the analytical method of the scheme described in Item 1, the adjustment information is set based on the reference analysis data of the reference sample containing the first substance with a known concentration and the second substance, and the reference analysis data of the reference sample containing the first substance with a known concentration and not containing the second substance. Thus, the influence of the analyte on the analysis can be reasonably obtained.

[0154] (Item 3) Another analytical method is, in the analytical method of the solution described in Item 2, the sample analysis data and the reference analysis data are respective analysis peaks and reference peaks corresponding to the first substance, and the adjustment information is set based on the relationship between the size of the analysis peak and the size of the reference peak. Thus, the influence of the analyte on the analysis can be efficiently obtained.

[0155] (Item 4) In another analysis method, in the analysis method of the solution described in Item 3, a threshold value of the analysis peak, i.e., an analysis peak threshold value, is set based on the adjustment information, and an evaluation related to the concentration of the first substance in the sample is performed based on a comparison between the analysis peak threshold value and the analysis peak. Thus, the sample can be accurately evaluated based on the concentration of the analyte.

[0156] (Item 5) Another analytical method is, in the analytical method of the scheme described in Item 3, generating a reference calibration curve for the first substance based on the reference peak, applying the sample analysis data to the reference calibration curve to obtain the analytical concentration of the first substance in the sample, setting a concentration threshold for evaluation related to the concentration of the first substance in the sample based on the analytical concentration and the adjustment information, and performing the evaluation based on a comparison between the concentration threshold and the analytical concentration. Thus, the sample can be accurately evaluated based on the concentration of the substance to be analyzed.

[0157] (Item 6) Another analytical method is, in the analytical method of the embodiment described in Item 5, the reference calibration curve is generated based on a plurality of reference peaks corresponding to the first substance obtained by analyzing a plurality of reference samples having different concentrations of the first substance. Thus, the sample can be evaluated more accurately based on the concentration of the analyte.

[0158] (Item 7) Another analytical method is, in the analytical method of the scheme described in Item 5 or Item 6, adjusting the reference calibration curve based on the adjustment information to generate an adjusted calibration curve, applying the sample analysis data to the adjusted calibration curve, and obtaining the analysis concentration of the first substance in the sample. Thus, the sample can be evaluated more accurately based on the concentration of the analyte.

[0159] (Item 8) Another analytical method is the analytical method of any one of Items 1 to 7, wherein the first substance is a bromine compound and the second substance is a chlorine compound. This allows for more accurate analysis of the concentration and mass of bromine compounds in a sample containing bromine compounds and chlorine compounds.

[0160] (Item 9) Another analytical method is that, in the analytical method of the method described in Item 8, the first substance is any one or more of polybrominated diphenyl ethers, polybrominated biphenyls, and other bromine-containing bromine-based flame retardants and additives, and the second substance is polyvinyl chloride and other chlorine-containing resins. Thus, the concentration and mass of the bromine-containing flame retardants or additives in a sample containing a compound of polybrominated diphenyl ethers, polybrominated biphenyls, other bromine-containing bromine-based flame retardants or additives and polyvinyl chloride (PVC) and / or other chlorine-containing resins can be analyzed more accurately.

[0161] (Item 10) Another analytical method is that, in the analytical method of the scheme described in Item 9, the other bromine-containing bromine-based flame retardant or additive is tetrabromobisphenol A and / or hexabromocyclododecane. Thus, the concentration and mass of the bromine-based flame retardant or additive in a sample containing a compound containing tetrabromobisphenol A and / or hexabromocyclododecane and polyvinyl chloride (PVC) and / or other chlorine-containing resins can be analyzed more accurately.

[0162] (Item 11) Another analytical method is the analytical method of any one of Items 1 to 10, wherein the analysis is performed by gas chromatography, liquid chromatography, mass spectrometry, gas chromatography / mass spectrometry, or liquid chromatography / mass spectrometry. Thus, the concentration and mass of the analyte contained in the analyte sample can be accurately analyzed by various analytical methods.

[0163] (Item 12) An analysis device of one embodiment is an analysis device that performs analysis related to the concentration of a sample containing a first substance and a second substance that affects the analysis of the first substance, and includes a processing device that derives an analysis result related to the concentration of the first substance based on sample analysis data obtained by analyzing the sample related to the concentration of the first substance and adjustment information based on the influence setting. Thus, the concentration and mass of the analysis target substance contained in the analysis target sample can be accurately analyzed.

[0164] (Item 13) Another embodiment of the analysis device is the analysis device of the embodiment described in Item 12, further comprising material information for setting at least one of the first material and the second material, wherein the adjustment information is generated based on the material information. Thus, the concentration and mass of the analysis target material contained in the analysis target sample can be analyzed accurately and efficiently.

[0165] (Item 14) Another embodiment of the analysis device is the analysis device of the embodiment described in Item 13, further comprising a display device, wherein the display device displays the relationship between the first substance and the second substance based on the substance information. Thus, the operator can easily recognize the relationship between the first substance and the second substance contained in the sample.

[0166] (Item 15) A computer readable medium (Non-transitory computer readable medium) of one embodiment is a computer readable medium storing a program for causing an analysis device to perform an analysis process, wherein the analysis process is an analysis process related to the concentration of the first substance performed on a sample containing a first substance and a second substance that exerts an influence on the analysis of the first substance, wherein the program derives an analysis result related to the concentration of the first substance based on sample analysis data obtained by analyzing the sample related to the concentration of the first substance and adjustment information set based on the influence. Thus, the analysis device can correctly perform an analysis of the concentration and mass of the analysis target substance contained in the analysis target sample.

[0167] The present invention is not limited to the contents of the above-mentioned embodiment, and other aspects that can be considered within the scope of the technical concept of the present invention are also included in the scope of the present invention.

[0168] Description of Reference Numerals

[0169] 1 Analysis device

[0170] 10 Thermal Decomposition Gas Chromatography

[0171] 14 Separation column

[0172] 20 Thermal decomposition device

[0173] 30 Quality Analysis Department

[0174] 33. Ionization unit

[0175] 35. Mass separation unit

[0176] 36. Inspection Department

[0177] 40 Information Processing Department

[0178] 44 Output

[0179] 50 Control Department

[0180] 52 Data Processing Department

[0181] 100 Measurement Department

[0182] 521 Concentration Calculation Unit

[0183] 522 Information Generation Department

[0184] 523 Judgment Department

[0185] 530 Notification Department

[0186] In ion.

Claims

1. An analysis method for performing analysis related to the concentration of the first substance on a sample containing a first substance and a second substance that affects the analysis of the first substance, characterized in that: The following steps are required: performing analysis on the sample related to the concentration of the first substance to obtain sample analysis data; deriving an analysis result related to the concentration of the first substance based on the sample analysis data and the adjustment information set based on the influence, The adjustment information is set based on reference analysis data of a reference sample containing the first substance at a known concentration and the second substance, and reference analysis data of a reference sample containing the first substance at a known concentration and not containing the second substance. The sample analysis data and the reference analysis data are analysis peaks and reference peaks corresponding to the first substance, respectively. setting the adjustment information based on the relationship between the size of the analysis peak and the size of the reference peak, The threshold of the analysis peak, i.e., the analysis peak threshold, is set based on the adjustment information. performing an evaluation related to the concentration of the first substance in the sample based on a comparison between the analytical peak threshold and the analytical peak, The analysis was performed by thermal decomposition gas chromatography-mass analysis.

2. An analysis method for performing analysis related to the concentration of the first substance on a sample containing a first substance and a second substance that affects the analysis of the first substance, characterized in that: The following steps are required: performing analysis on the sample related to the concentration of the first substance to obtain sample analysis data; deriving an analysis result related to the concentration of the first substance based on the sample analysis data and the adjustment information set based on the influence, The adjustment information is set based on reference analysis data of a reference sample containing the first substance at a known concentration and the second substance, and reference analysis data of a reference sample containing the first substance at a known concentration and not containing the second substance. The sample analysis data and the reference analysis data are analysis peaks and reference peaks corresponding to the first substance, respectively. setting the adjustment information based on the relationship between the size of the analysis peak and the size of the reference peak, generating a reference calibration curve for the first substance based on the reference peak, applying the sample analysis data to the reference calibration curve to obtain the analysis concentration of the first substance in the sample, setting a concentration threshold value for evaluation related to the concentration of the first substance in the sample based on the analysis concentration and the adjustment information, The evaluation is performed based on a comparison between the concentration threshold and the analysis concentration, The analysis was performed by thermal decomposition gas chromatography-mass analysis.

3. The analysis method according to claim 2, characterized in that The reference calibration curve is generated based on the plurality of reference peaks corresponding to the first substance obtained by analyzing the plurality of reference samples having different concentrations of the first substance.

4. The analysis method according to claim 2 or 3, characterized in that adjusting the reference calibration curve based on the adjustment information to generate an adjusted calibration curve, The sample analysis data is applied to the adjusted calibration curve to obtain the analysis concentration of the first substance in the sample.

5. The analysis method according to claim 1 or 2, characterized in that The first substance is a bromine compound, and the second substance is a chlorine compound.

6. The analysis method according to claim 5, characterized in that The first substance is any one or more of polybrominated diphenyl ethers, polybrominated biphenyls, and other bromine-containing bromine flame retardants and additives, and the second substance is polyvinyl chloride (PVC) and other chlorine-containing resins.

7. The analysis method according to claim 6, characterized in that The other bromine-containing bromine-based flame retardants and additives are tetrabromobisphenol A and / or hexabromocyclododecane.

8. An analysis device for performing analysis related to the concentration of a first substance on a sample containing a first substance and a second substance that affects analysis of the first substance, characterized in that: A processing device is provided, wherein the processing device derives an analysis result related to the concentration of the first substance based on sample analysis data obtained by analyzing the sample related to the concentration of the first substance and adjustment information based on the influence setting, The adjustment information is set based on reference analysis data of a reference sample containing the first substance at a known concentration and the second substance, and reference analysis data of a reference sample containing the first substance at a known concentration and not containing the second substance. The sample analysis data and the reference analysis data are analysis peaks and reference peaks corresponding to the first substance, respectively. setting the adjustment information based on the relationship between the size of the analysis peak and the size of the reference peak, The threshold of the analysis peak, i.e., the analysis peak threshold, is set based on the adjustment information. performing an evaluation related to the concentration of the first substance in the sample based on a comparison between the analytical peak threshold and the analytical peak, The analysis was performed by thermal decomposition gas chromatography-mass analysis.

9. An analysis device for performing analysis related to the concentration of a first substance on a sample containing a first substance and a second substance that affects analysis of the first substance, characterized in that: A processing device is provided, wherein the processing device derives an analysis result related to the concentration of the first substance based on sample analysis data obtained by analyzing the sample related to the concentration of the first substance and adjustment information based on the influence setting, The adjustment information is set based on reference analysis data of a reference sample containing the first substance at a known concentration and the second substance, and reference analysis data of a reference sample containing the first substance at a known concentration and not containing the second substance. The sample analysis data and the reference analysis data are analysis peaks and reference peaks corresponding to the first substance, respectively. setting the adjustment information based on the relationship between the size of the analysis peak and the size of the reference peak, generating a reference calibration curve for the first substance based on the reference peak, applying the sample analysis data to the reference calibration curve to obtain the analysis concentration of the first substance in the sample, setting a concentration threshold value for evaluation related to the concentration of the first substance in the sample based on the analysis concentration and the adjustment information, The evaluation is performed based on a comparison between the concentration threshold and the analysis concentration, The analysis was performed by thermal decomposition gas chromatography-mass analysis.

10. The analysis device according to claim 8 or 9, characterized in that further comprising material information setting at least one of the first material and the second material, The adjustment information is generated based on the substance information.

11. The analysis device according to claim 10, characterized in that A display device is further provided, the display device displaying the relationship between the first substance and the second substance based on the substance information.

12. A computer readable medium, i.e., a non-transitory computer readable medium, storing a program for causing an analysis device to perform an analysis process, wherein the analysis process is an analysis process related to the concentration of the first substance performed on a sample containing a first substance and a second substance that affects the analysis of the first substance, characterized in that: The program derives, in the analysis process, an analysis result related to the concentration of the first substance based on sample analysis data obtained by analyzing the sample related to the concentration of the first substance and adjustment information based on the influence setting, The adjustment information is set based on reference analysis data of a reference sample containing the first substance at a known concentration and the second substance, and reference analysis data of a reference sample containing the first substance at a known concentration and not containing the second substance. The sample analysis data and the reference analysis data are analysis peaks and reference peaks corresponding to the first substance, respectively. setting the adjustment information based on the relationship between the size of the analysis peak and the size of the reference peak, The threshold of the analysis peak, i.e., the analysis peak threshold, is set based on the adjustment information. performing an evaluation related to the concentration of the first substance in the sample based on a comparison between the analytical peak threshold and the analytical peak, The analysis was performed by thermal decomposition gas chromatography-mass analysis.

13. A computer readable medium, i.e., a non-transitory computer readable medium, storing a program for causing an analysis device to perform an analysis process, wherein the analysis process is an analysis process related to the concentration of the first substance performed on a sample containing a first substance and a second substance that affects the analysis of the first substance, characterized in that: The program derives, in the analysis process, an analysis result related to the concentration of the first substance based on sample analysis data obtained by analyzing the sample related to the concentration of the first substance and adjustment information based on the influence setting, The adjustment information is set based on reference analysis data of a reference sample containing the first substance at a known concentration and the second substance, and reference analysis data of a reference sample containing the first substance at a known concentration and not containing the second substance. The sample analysis data and the reference analysis data are analysis peaks and reference peaks corresponding to the first substance, respectively. setting the adjustment information based on the relationship between the size of the analysis peak and the size of the reference peak, generating a reference calibration curve for the first substance based on the reference peak, applying the sample analysis data to the reference calibration curve to obtain the analysis concentration of the first substance in the sample, setting a concentration threshold value for evaluation related to the concentration of the first substance in the sample based on the analysis concentration and the adjustment information, The evaluation is performed based on a comparison between the concentration threshold and the analysis concentration, The analysis was performed by thermal decomposition gas chromatography-mass analysis.

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