A gastrointestinal motility disorder detection system

Abstract

The present application discloses a gastrointestinal motility disorder detection system, comprising a measuring catheter, a measuring host, and an impedance detection device; the measuring catheter is provided with a pressure detection device and an impedance detection device; a wire bundle in the measuring catheter is connected to the measuring host, for transmitting the pressure signal and impedance signal detected by the pressure detection device and the impedance detection device to the measuring host via the wire bundle; the measuring host is used to record the pressure signal and the impedance signal. Compared to the current technology that only detects gastrointestinal pressure, the present technical solution adopts an impedance detection device, and when a food bolus passes through the impedance detection device, it causes a change in impedance. The position of the food bolus can be determined based on the position of the impedance change, thereby enabling the assessment of the movement and residual state of the food bolus after swallowing in the esophagus. The pressure signal is obtained by the pressure detection device to detect the esophageal contraction pressure.

Description

Technical Field

[0001] The present application relates to the field of medical devices, and in particular to a gastrointestinal motility disorder detection system. Background Art

[0002] Gastrointestinal motility disorders account for over 25% of outpatient visits to gastroenterology clinics. These disorders often lack clinical signs, with no structural changes or biochemical abnormalities in the early stages, and are therefore undetectable using traditional gastroscopy and gastrointestinal imaging techniques. Gastroesophageal reflux disease (GERD), the most common gastrointestinal motility disorder, has long plagued numerous patients, impacting their work and personal lives and requiring repeated visits to the doctor. In recent years, the incidence of GERD has been increasing year by year.

[0003] Current technology typically uses solid-state high-resolution pressure measurement systems. These systems employ densely distributed pressure sensors to synchronously collect pressure data across the entire esophagus. These data are then converted into three-dimensional images using computer software. This provides a method for studying the driving force that moves food and liquid from the pharynx to the stomach, and can also determine the risk of reflux events. However, this system only measures and evaluates esophageal contraction pressure. Pressure testing alone cannot fully assess the movement and residual content of the food bolus after swallowing, which impacts the accurate diagnosis of gastrointestinal motility disorders.

[0004] It can be seen that how to more accurately detect gastrointestinal motility disorders is an urgent problem to be solved by those skilled in the art. Summary of the Invention

[0005] The purpose of this application is to provide a gastrointestinal motility disorder detection system for more accurate detection of gastrointestinal motility disorders.

[0006] To solve the above technical problems, the present application provides a gastrointestinal motility disorder detection system, which includes:

[0007] Measuring catheter, measuring host, impedance detection device;

[0008] The measuring catheter is provided with a pressure detection device and the impedance detection device;

[0009] The wire bundle in the measuring conduit is connected to the measuring host, and is used to transmit the pressure signal and impedance signal detected by the pressure detection device and the impedance detection device to the measuring host through the wire bundle;

[0010] The measurement host is used to record the pressure signal and the impedance signal.

[0011] Preferably, the impedance detection device includes at least two impedance rings, and the impedance rings are arranged at intervals in the extension direction of the measuring catheter.

[0012] Preferably, the measuring catheter comprises multiple sections, and the pressure detection device comprises: a pressure sensor, a balloon, and a filler;

[0013] One of the pressure detection devices and the two impedance rings constitutes a connecting portion for connecting multiple sections of the measuring conduit, wherein the pressure detection device in the connecting portion is located between the two impedance rings;

[0014] The pressure sensor is connected to the wire bundle and placed inside the balloon, and the interior of the balloon is filled with the filler.

[0015] Preferably, there are 36 connecting parts in total, which evenly connect multiple sections of the measuring catheter.

[0016] Preferably, the connection portions are spaced 1 cm apart.

[0017] Preferably, the impedance signal detected by the impedance detection device is the impedance signal between the three connected connection parts.

[0018] Preferably, the pressure sensor is a silicon piezoresistive pressure sensor.

[0019] Preferably, the measuring host controls switching of the impedance detection channel and the pressure detection device through a multi-way analog switch to obtain the impedance signal and the pressure signal at different positions.

[0020] Preferably, the filler is liquid or colloid.

[0021] Preferably, it further comprises: a host computer connected to the measurement host, for evaluating gastrointestinal motility disorders based on the recorded pressure signal and the impedance signal and saving the evaluation results.

[0022] The gastrointestinal motility disorder detection system provided by the present application includes a measuring catheter, a measuring host, and an impedance detection device; the measuring catheter is provided with a pressure detection device and an impedance detection device; the wire bundle in the measuring catheter is connected to the measuring host, and is used to transmit the pressure signal and impedance signal detected by the pressure detection device and the impedance detection device to the measuring host through the wire bundle; the measuring host is used to record the pressure signal and the impedance signal. Compared with the current technology, which only detects the pressure of the stomach and intestine, the present technical solution uses an impedance detection device to add an impedance detection device. When the food bolus passes through the impedance detection device, it causes a change in impedance. The position of the food bolus can be determined based on the position of the impedance change, thereby realizing the evaluation of the movement and residual state of the food bolus after swallowing in the esophagus. In addition, the pressure signal is obtained by the pressure detection device to realize the detection of the esophageal contraction pressure. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] In order to more clearly illustrate the embodiments of the present application, the following is a brief introduction to the drawings required for use in the embodiments. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without any creative work.

[0024] Figure 1 A structural diagram of a gastrointestinal motility disorder detection system provided in an embodiment of the present application;

[0025] Figure 2 A structural diagram of a measurement catheter provided in an embodiment of the present application;

[0026] Figure 3 A structural diagram of a pressure monitoring device provided in an embodiment of the present application;

[0027] Figure 4 A flowchart of a method for a measuring host to obtain an impedance signal and a pressure signal provided in an embodiment of the present application;

[0028] The reference numerals are as follows: 1 is a measuring catheter, 2 is a measuring host, 3 is a host computer, 4 is an impedance loop, 5 is a pressure detection device, 6 is a wire bundle, 7 is a balloon, 8 is a filler, and 9 is a pressure sensor. DETAILED DESCRIPTION

[0029] The following will be combined with the accompanying drawings in the embodiments of this application to clearly and completely describe the technical solutions in the embodiments of this application. Obviously, the embodiments described are only part of the embodiments of this application, not all of them. Based on the embodiments in this application, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of this application.

[0030] The core of this application is to provide a gastrointestinal motility disorder detection system.

[0031] In order to enable those skilled in the art to better understand the present application, the present application is further described in detail below with reference to the accompanying drawings and specific implementation methods.

[0032] Figure 1 This is a structural diagram of a gastrointestinal motility disorder detection system provided in an embodiment of the present application, such as Figure 1 As shown, the system includes:

[0033] Measuring catheter 1, measuring host 2, impedance detection device;

[0034] The measuring catheter 1 is provided with a pressure detection device 5 and an impedance detection device;

[0035] The wire bundle 6 in the measuring catheter 1 is connected to the measuring host 2 and is used to transmit the pressure signal and impedance signal detected by the pressure detection device 5 and the impedance detection device to the measuring host 2 through the wire bundle 6;

[0036] The measuring host 2 is used to record pressure signals and impedance signals.

[0037] In this embodiment, the measuring catheter 1 plays the role of connection and fixation. In a specific implementation, the portion of the measuring catheter 1 provided with the pressure detection device 5 and the impedance detection device will be inserted into the esophagus to evaluate the gastrointestinal motility based on the obtained pressure and impedance. It is understandable that, in addition to the portion of the measuring catheter 1 inserted into the esophagus, there should also be a portion remaining outside the patient's body, which is not provided with the pressure detection device 5 and the impedance detection device, so as to facilitate the insertion and removal of the measuring catheter 1 in the esophagus. In a specific implementation, the wire bundle 6 in the measuring catheter 1 is connected to the measuring host 2 for data transmission. The wire bundle 6 can be partially placed in the measuring catheter 1 or all of it can be placed in the measuring catheter 1. As Figure 1 As shown, a measuring catheter 1 equipped with a pressure detection device 5 and an impedance detection device is inserted into the patient's esophagus. The measuring catheter 1 outside the patient's body is wrapped with a wire bundle 6 and connected to the measuring host 2, and interaction is achieved through the wire bundle 6. In addition, the measuring host 2 can send the recorded pressure signal and impedance signal to the host computer 3 for data evaluation, organization, presentation and storage. It should be noted that the measuring catheter 1 needs to be inserted into the patient's esophagus, so the pressure detection device 5 and the impedance detection device should not cause harm to the patient. In a specific implementation, in order to comprehensively and accurately evaluate gastrointestinal motility disorders, there should be multiple pressure detection devices 5 and impedance detection devices, and it should be ensured that the pressure and impedance in the esophagus can be evenly collected after being inserted into the esophagus.

[0038] The gastrointestinal motility disorder detection system provided by the present application includes a measuring catheter, a measuring host, and an impedance detection device; the measuring catheter is provided with a pressure detection device and an impedance detection device; the wire bundle in the measuring catheter is connected to the measuring host, and is used to transmit the pressure signal and impedance signal detected by the pressure detection device and the impedance detection device to the measuring host through the wire bundle; the measuring host is used to record the pressure signal and the impedance signal. Compared with the current technology, which only detects the pressure of the stomach and intestine, the present technical solution uses an impedance detection device to add an impedance detection device. When the food bolus passes through the impedance detection device, it causes a change in impedance. The position of the food bolus can be determined based on the position of the impedance change, thereby realizing the evaluation of the movement and residual state of the food bolus after swallowing in the esophagus. In addition, the pressure signal is obtained by the pressure detection device to realize the detection of the esophageal contraction pressure.

[0039] On the basis of the above embodiments, this embodiment provides a specific impedance detection device. In this embodiment, the impedance detection device includes at least two impedance rings 4 , and each impedance ring 4 is arranged at intervals in the extension direction of the measuring catheter 1 .

[0040] In this embodiment, two impedance loops 4 on the measuring catheter 1 are connected via a wire harness 6 to form an impedance detection channel. An excitation signal is applied to one impedance loop 4, while the signal is received by the other impedance loop 4. The impedance between the two impedance loops 4 forms an excitation signal loop. Within this loop, an impedance measurement signal is sampled at the output of the excitation signal, filtered, and amplified to form a DC signal. The DC signal voltage amplitude reflects the impedance between the two impedance loops 4.

[0041] It is understood that the measurement catheter 1 should have multiple impedance detection devices, which constitute multiple impedance detection channels. The measurement host 2 continuously detects the impedance of the multiple impedance detection channels. When a food bolus contacts the measurement catheter 1, the impedance of the impedance detection channel where the contacted measurement catheter 1 is located changes, thereby enabling the measurement host 2 to track the food bolus.

[0042] This embodiment provides a specific impedance detection device, which applies and receives excitation signals through two impedance loops, thereby realizing impedance detection.

[0043] In a specific implementation, the pressure detection device 5 needs to detect the contraction pressure of the esophagus and cannot cause harm to the patient. This embodiment provides a specific pressure detection device 5. In this embodiment, the measuring catheter 1 includes multiple sections, and the pressure detection device 5 includes: a pressure sensor 9, a balloon 7, and a filler 8;

[0044] A pressure detection device 5 and two impedance rings 4 form a connecting portion for connecting multiple sections of measuring catheters 1, wherein the pressure detection device 5 in the connecting portion is located between the two impedance rings 4;

[0045] The pressure sensor 9 is connected to the wire harness 6 and placed inside the balloon 7 , and the interior of the balloon 7 is filled with a filler 8 .

[0046] In a specific implementation, the pressure detection device 5 can be arranged on one side of the measuring tube 1, or can be formed by connecting multiple sections of the measuring tube 1. It is understandable that if the pressure detection device 5 is distributed on one side of the measuring tube 1, it is impossible to accurately detect the contraction pressure of the esophagus. Therefore, Figure 2 This is a structural diagram of a measuring catheter 1 provided in an embodiment of the present application, as shown in FIG. Figure 2 As shown, a pressure sensor 9 and two impedance loops 4 form a connecting portion, which sequentially connects multiple sections of measuring catheters 1. Figure 3This is a structural diagram of a pressure detection device 5 provided in an embodiment of the present application, as shown in FIG. Figure 3 As shown, the pressure sensor 9 in the pressure detection device 5 is connected to the wire harness 6. When the external balloon 7 is squeezed, the pressure is transmitted to the pressure sensor 9 through the filler 8 inside the balloon 7. The pressure sensor 9 then transmits the measured pressure to the measurement host 2 via the wire harness 6. It will be understood that to ensure the accuracy of pressure transmission, the filler 8 should fill the balloon 7 without leaving any gaps.

[0047] The gastrointestinal motility disorder detection system provided in this embodiment comprises a pressure detection device and two impedance loops forming a connecting portion, which connects to a multi-section measuring catheter, enabling the pressure detection device to comprehensively detect esophageal contraction pressure. Furthermore, this embodiment provides a specific structure for a pressure monitoring device, which incorporates a pressure sensor within a balloon to avoid harm to the patient and transmits pressure through a filler to achieve pressure detection.

[0048] In order to comprehensively detect the movement of the food bolus in the esophagus, in this embodiment, there are 36 connecting parts, which evenly connect multiple sections of the measuring catheter 1.

[0049] It should be noted that, in this embodiment, the evenly connected multi-section measuring catheter 1 refers to the measuring catheter 1 that needs to be inserted into the esophagus.

[0050] This embodiment uses 36 connecting parts to achieve comprehensive tracking and detection of the contraction pressure of different parts of the esophagus and the movement of the food bolus.

[0051] Based on the above embodiment, in this embodiment, the interval between each connecting portion is 1 cm.

[0052] According to the length of the esophagus, the 36 connecting parts are distributed at intervals of 1 cm, which can fully cover the esophagus and facilitate comprehensive detection of the movement of the food bolus.

[0053] When the food bolus contacts the measuring catheter 1, the deformation causes a change in impedance. The measuring device 2 continuously releases excitation signals to detect the impedance, thereby tracking the trajectory of the food bolus's movement. However, it is understandable that if the impedance detection channel is too long, the data obtained will be inaccurate, and only the general location of the food bolus can be measured, but the specific location of the food bolus cannot be determined. If the impedance detection channel is too long, a large number of excitation signals must be released, which will affect the efficiency of impedance detection and eliminate the need for excessive food bolus position data for subsequent analysis of motility disorders.

[0054] Therefore, in this embodiment, the impedance signal detected by the impedance detection device is the impedance signal between the three connected connection parts.

[0055] This embodiment uses three connecting parts as an impedance detection channel. When 36 connecting parts are evenly spaced 1 cm apart, the impedance detection channel between three connected connecting parts is 2 cm. This embodiment detects the impedance signal between three connected connecting parts, accurately determining the location of the food bolus while reducing the number of excitation signal transmissions and the amount of data processing.

[0056] This embodiment provides a specific selection type of pressure sensor 9. In this embodiment, the pressure sensor 9 is a silicon piezoresistive pressure sensor.

[0057] Silicon piezoresistive pressure sensors are made using the piezoresistive effect of single-crystal silicon. Using a single-crystal silicon wafer as the elastic element, a set of equal-value resistors are diffused in specific directions on the single-crystal silicon diaphragm using integrated circuit technology. These resistors are then connected to form a bridge circuit, and the single-crystal silicon wafer is placed within the sensor cavity. When pressure changes, the single-crystal silicon strains, causing the strained resistors directly diffused on it to change proportionally to the measured pressure. The bridge circuit then generates a corresponding voltage output signal. Due to their compact size, silicon piezoresistive pressure sensors are widely used in medical devices.

[0058] Figure 4 A flow chart of a method for a measuring host to obtain an impedance signal and a pressure signal provided in an embodiment of the present application is shown as follows: Figure 4 As shown, the measuring host 2 controls the switching of the impedance detection channel and the pressure detection device 5 through a multi-way analog switch to obtain impedance signals and pressure signals at different positions.

[0059] like Figure 4 As shown, when obtaining the pressure signal, the output signals of multiple pressure sensors 9 are connected to the filter amplifier in a time-sharing manner through the multi-way analog switch, and then connected to the first analog-to-digital conversion module AD1. The CPU in the measuring host 2 controls AD1 to collect data from the pressure sensor 9, and the CPU controls the multi-way analog switch to realize time-sharing collection of the multiple pressure sensors 9.

[0060] When acquiring the impedance signal, the CPU controls the digital-to-analog conversion module DA to generate the excitation sine wave required for measuring the impedance. After the sine wave is amplified, it is switched to different impedance loops 4 for measurement excitation through a multi-way analog switch in a time-sharing manner. At the same time, another multi-way analog switch connects the impedance loop 4 corresponding to the impedance channel through the action of the reference voltage, and an excitation signal loop is formed through the impedance between the two impedance loops 4. In this loop, the impedance measurement signal is sampled at the output end of the excitation signal amplifier, and then the sampled signal is filtered and amplified to form a DC signal. The DC signal voltage amplitude reflects the impedance size between the two impedance loops 4. The CPU controls the second analog-to-digital conversion module AD2 to perform data acquisition on the DC signal, thereby realizing the measurement of the impedance value of the channel. The CPU controls the multi-way analog switch to switch in a time-sharing manner to realize the impedance measurement of multiple impedance channels.

[0061] This embodiment uses a multi-channel analog switch to achieve time-sharing acquisition of impedance signals and pressure signals at different positions.

[0062] In order to ensure that the pressure of the balloon 7 can be accurately transmitted to the pressure sensor 9 after being squeezed, in this embodiment, the filler 8 is liquid or colloid.

[0063] It is understood that liquids or colloids can transmit pressure more accurately than solids.

[0064] On the basis of the above embodiment, this embodiment further includes: a host computer 3, which is connected to the measurement host 2 and is used to evaluate gastrointestinal motility disorders based on the recorded pressure signals and impedance signals and save the evaluation results.

[0065] The pressure signal and impedance signal obtained from the pressure detection device and the impedance detection device are sent to the host computer 3 by the measuring host 2. The host computer 3 evaluates the gastrointestinal motility disorder based on the recorded pressure signal and impedance signal, and can form an electronic diagnosis report based on the evaluation results. The report can be stored in the host computer 3 or output to the printer to form a paper diagnosis report.

[0066] The above is a detailed introduction to the gastrointestinal motility disorder detection system provided by the present application. The various embodiments in the specification are described in a progressive manner, and each embodiment focuses on the differences from other embodiments. The same and similar parts between the various embodiments can be referred to each other. For the device disclosed in the embodiment, since it corresponds to the method disclosed in the embodiment, the description is relatively simple, and the relevant parts can be referred to the method part description. It should be pointed out that for ordinary technicians in this technical field, without departing from the principles of this application, several improvements and modifications can be made to the present application, and these improvements and modifications also fall within the scope of protection of the claims of this application.

[0067] It should also be noted that, in this specification, relational terms such as first and second, etc., are used only to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "comprises," "comprising," or any other variants thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus comprising a series of elements includes not only those elements, but also other elements not explicitly listed, or elements inherent to such process, method, article, or apparatus. In the absence of further limitations, an element defined by the phrase "comprising a ..." does not exclude the presence of additional identical elements in the process, method, article, or apparatus comprising the element.

Claims

1. A gastrointestinal motility disorder detection system, characterized in that: include: Measuring catheter, measuring host, impedance detection device; The measuring catheter is provided with a pressure detection device and the impedance detection device; The impedance detection device comprises at least two impedance rings, each of which is arranged at intervals in the extension direction of the measuring catheter; the two impedance rings on the measuring catheter are connected by a wire bundle to form an impedance detection channel; One of the pressure detection devices and the two impedance rings constitutes a connecting portion for connecting multiple sections of the measuring conduit, wherein the pressure detection device in the connecting portion is located between the two impedance rings; The impedance detection channel and the connecting portion are spaced apart; The wire bundle in the measuring catheter is connected to the measuring host, and is used to transmit the pressure signal and impedance signal detected by the pressure detection device and the impedance detection device to the measuring host through the wire bundle; wherein the impedance signal detected by the impedance detection device is the impedance signal between the three connected connecting parts; The measurement host is used to record the pressure signal and the impedance signal.

2. The gastrointestinal motility disorder detection system according to claim 1, characterized in that: The measuring catheter comprises multiple sections, and the pressure detection device comprises: a pressure sensor, a balloon, and a filler; The pressure sensor is connected to the wire bundle and placed inside the balloon, and the interior of the balloon is filled with the filler.

3. The gastrointestinal motility disorder detection system according to claim 2, characterized in that: There are 36 connecting parts in total, which evenly connect multiple sections of the measuring catheter.

4. The gastrointestinal motility disorder detection system according to claim 3, characterized in that: The connection parts are spaced 1 cm apart.

5. The gastrointestinal motility disorder detection system according to claim 2, characterized in that: The pressure sensor is a silicon piezoresistive pressure sensor.

6. The gastrointestinal motility disorder detection system according to claim 5, characterized in that: The measuring host controls switching of the impedance detection channel and the pressure detection device through a multi-way analog switch to obtain the impedance signal and the pressure signal at different positions.

7. The gastrointestinal motility disorder detection system according to any one of claims 2 to 6, characterized in that: The filler is liquid or colloid.

8. The gastrointestinal motility disorder detection system according to claim 1, characterized in that: Also includes: A host computer is connected to the measurement host and is used to evaluate gastrointestinal motility disorders based on the recorded pressure signal and the impedance signal and save the evaluation results.

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