Personal lubricant composition

Abstract

The present invention provides a personal lubricant composition comprising a humectant and a thixotropic agent, wherein the thixotropic agent comprises a combination of i) one or more celluloses and ii) one or more alkali metal carboxyalkyl celluloses. The composition can be sprayable and provided in a pump spray device or squeeze-type spray bottle. The present invention also provides a method of providing personal lubrication comprising dispensing the composition to a target area, and use of the composition to provide lubrication during sexual activity.

Description

Technical Field

[0001] This invention relates to a personal lubricant composition. In a preferred embodiment, the invention relates to a sprayable personal lubricant that has a lower osmolality compared to existing sprayable personal lubricants, while maintaining lubricity and good texture, skin feel, and other desired properties. Background Technology

[0002] Personal lubricants are well-known for achieving close contact. They are typically sold in liquid, gel, suppository, or liquid form. Examples of such products include KY. ® gelatin, Astroglide ® KY ® Liquid, KY ® Ultragel TM Recently, KY ® Heating fluid has entered the market. KY ® The heating fluid is a water-soluble anhydrous composition that heats the body upon contact with it while also providing lubrication.

[0003] Most commercially available personal lubricants are applied by first applying them to the user's hands or fingers and then to the genital area. This can be undesirable and messy. Additionally, some people are reluctant to apply personal lubricant directly to the genital area.

[0004] One method of delivering lubricant without using hands is by spraying, for example, dispensing the lubricant from a sprayer or pressurized container. However, not all lubricants are suitable for spraying. In particular, personal lubricants often have high viscosity, which prevents them from being sprayed. Reducing the viscosity of such personal lubricant compositions by diluting them in a liquid facilitates spraying but results in a loss of lubricity.

[0005] US 2007 / 0059250 and US 2007 / 059266 describe personal lubricant compositions capable of being sprayed onto a target area while maintaining lubrication. However, the compositions in specific examples of these documents rely on high levels of humectants (≥30% by weight), particularly glycerin and / or propylene glycol, to provide the desired sprayability and lubrication. This results in a weight molar osmolality concentration of the compositions higher than the World Health Organization recommended level of less than 1200 mOsm / kg (see "Use and availability of supplemental lubricants for male and female condoms: WHO / UNFPA / FHI360 Advisory Note, WHO Advisory Note, 2012:1-8"). Furthermore, it has been found that the compositions described in US 2007 / 0059250 and US 2007 / 059266 tend to be sprayed as a jet or a series of large, polydisperse droplets from a typical atomizer or pressurized container, rather than a gentle, clean mist.

[0006] WO 2018 / 200014 discloses a method of contraception using a thixotropic Bingham plastic fluid for application into the vaginal fornix. It may contain a mixture of microcrystalline cellulose and sodium carboxymethyl cellulose, but not other elements such as propylene glycol or glycerin. Embodiments of this composition are allegedly also suitable for use as a personal lubricant. However, when used as a lubricant for sexual activity rather than contraception, the actual properties of the composition in this document, such as texture, skin feel, "adhesion," and level of lubrication, fall far short of consumer needs. Summary of the Invention

[0007] It is desirable to provide a personal lubricant composition that is both aerosolizable and lubricating, while having a low weight molar osmotic pressure concentration and desired sensory properties.

[0008] Alternatively or additionally, it is desirable to provide a personal lubricant composition that can be dispensed as a fine mist.

[0009] According to a first aspect of the invention, a personal lubricant composition comprising a humectant and a thixotropic agent is provided, wherein the thixotropic agent comprises i) one or more celluloses and ii) one or more carboxyalkyl cellulose alkali metals. As used herein, "cellulose" does not include cellulose ethers or cellulose esters, but the one or more celluloses may have any molecular weight and may be microcrystalline cellulose.

[0010] The inventors have discovered that including this specific thixotropic agent allows the composition to be sprayed as a gentle mist without requiring the use of high levels of humectant as illustrated in the compositions of US 2007 / 0059250 and US 2007 / 059266. Surprisingly, the lubricating properties of the composition are maintained even with low levels of humectant. Advantageously, in one embodiment, low levels of humectant can be used, resulting in a composition with a low molality osmotic pressure concentration. Therefore, a sprayable personal lubricant composition exhibiting low molality osmotic pressure concentration and good lubricity is described herein. The composition can be non-adhesive and leaves no perceptible residue.

[0011] Surprisingly, it was also found that the specific thixotropic agents disclosed herein can produce compositions that provide consistent lubricity before and after spraying across a wide range of shear rates. This means that the personal lubricant compositions can be designed to provide good lubricity regardless of the speed of sexual activity, even after spraying.

[0012] The invention will now be described further. In the following paragraphs, different aspects / implementations of the invention are defined in more detail. Each aspect / implementation thus defined may be combined with any other one or more aspects / implementations unless explicitly indicated to the contrary. In particular, any feature indicated as preferred or advantageous may be combined with any other one or more features indicated as preferred or advantageous.

[0013] As used herein, the phrase "personal lubricant composition" refers to those types of compositions that provide lubrication during personal or sexual relations / activities, preferably during sexual activity. The personal lubricant composition of the present invention can be applied to the vagina, vaginal area, perineum, anal area, penis, or mouth. Preferably, it is suitable for lubricating at least the vagina, vaginal area, perineum, anal area, or penis, and more preferably suitable for lubricating at least the vagina, vaginal area, or penis. The composition can also be applied to devices such as medical devices, gloves, or sexually related devices (e.g., vibrators, sexual aids, etc.). For example, it can be used for lubricating medical devices or gloves used during gynecological examinations.

[0014] The personal lubricant compositions disclosed herein are preferably atomizable. “Atomizable” means that the composition can be presented as a mist of particles from a pump-type spray device or a squeeze-type spray bottle. As used herein, the term “mist” refers to a spray pattern without a well-defined outer boundary.

[0015] In one embodiment, the pump-type spray device includes a spray pump actuator assembly. In another embodiment, the pump-type spray device includes a vortex chamber. In this embodiment, the composition is typically drawn into the chamber through a suction tube. Once inside the vortex chamber, the composition is broken down into tiny particles or a fine spray, which is then discharged.

[0016] Once the spray pump is started, the composition is delivered to the defined target area in a predetermined amount. In one embodiment, the pump may require at least two strokes to start. In another embodiment, the pump may require at least three strokes to start. During startup, the composition is drawn upward into the vortex chamber through the actuator along the suction tube and is eventually discharged. In one embodiment, each single-stroke spray pump delivers 120 to 160 μL of the composition to the defined target area.

[0017] For it to be atomizable in the preferred embodiment, the composition of the present invention should be able to be atomized into particles having the following size distribution, given with respect to the 10th, 50th, and 90th percentiles:

[0018]

[0019] Preferably, the particle size at 25 cm should be at most about 60 μm at the 10th percentile, at most about 100 μm at the 50th percentile, and at most about 200 μm at the 90th percentile. Preferably, a Malvern Spraytec laser diffractometer is used to measure the particle size.

[0020] Preferably, the compositions disclosed herein can be sprayed from a pump-type spray device or a squeeze-type spray bottle, and more preferably, the compositions are atomized upon spraying into particles having a size distribution defined as D[v, 0.1] of up to about 60 μm, D[v, 0.5] of up to about 100 μm, and D[v, 0.9] of up to about 200 μm. The particle size distribution is preferably determined at a distance of 25 cm from the spray source and / or using a Malvern Spraytec laser diffractometer.

[0021] In one embodiment, the spray pump can be a two-way pump, that is, the composition contained in the pump can be dispensed from either an upright or inverted configuration, allowing the user to spray "upside down".

[0022] Preferably, the compositions and methods of the present invention enable the composition to be dispensed with minimal dispersion from a location far from the target area to an unwanted area. For example, the composition can be sprayed onto the target area with reasonable accuracy from a distance of at least about 8 cm, preferably at least about 30 cm.

[0023] The compositions of the present invention comprise a thixotropic agent comprising: i) one or more celluloses; and ii) one or more carboxyalkyl cellulose alkali metals. In one embodiment, the thixotropic agent consists of a cellulose and a carboxyalkyl cellulose alkali metal. The inclusion of a thixotropic agent means that the composition is preferably a non-Newtonian thixotropic fluid, exhibiting a reduced apparent viscosity under shear stress but a high apparent viscosity at rest; this property allows for immediate application by spraying with readily available pump-type sprayers or squeeze-type spray bottles after the application of shear stress (e.g., shear stress generated by vigorous shaking of the product container), but keeps the sprayed material relatively fixed, at least temporarily, on mucous membranes or skin. As described above, the inventors have found that including the specific thixotropic agent described herein, particularly a combination of one or more celluloses and one or more carboxyalkyl cellulose alkali metals, enables the composition to be sprayed in a mild mist form while maintaining lubricity, without the need for the high levels of humectants (e.g., glycerin and / or propylene glycol) used in prior art compositions. Preferably, the alkyl group in the one or more carboxyalkyl cellulose alkali metals is selected from methyl, ethyl, propyl, and butyl, more preferably methyl or ethyl, and most preferably methyl. Preferably, the alkali metal in the one or more carboxyalkyl cellulose alkali metals is selected from lithium, sodium, and potassium, and more preferably sodium.

[0024] As mentioned above, it is also surprising to find that the specific thixotropic agents disclosed herein ideally produce compositions that provide consistent lubricity before and after spraying across a wide range of shear rates. This means that the personal lubricant compositions will achieve their purpose regardless of the speed of sexual activity, even after spraying.

[0025] Preferably, the composition exhibits a very rapid viscosity recovery rate after the shear force is removed.

[0026] Preferably, the thixotropic agent comprises a combination of microcrystalline cellulose and a carboxyalkyl cellulose alkali metal (more preferably sodium carboxymethyl cellulose) as described above. In one embodiment, the thixotropic agent comprises 85 to 95 wt% (preferably 86 to 92 wt%) of one or more celluloses and 5 to 15 wt% (preferably 8 to 14 wt%) of one or more carboxyalkyl cellulose alkali metals, or the like. Typically, the thixotropic agent comprises 85 to 95 wt% microcrystalline cellulose and 5 to 15 wt% sodium carboxymethyl cellulose, or the like. More typically, the thixotropic agent comprises 86 to 92 wt% microcrystalline cellulose and 8 to 14 wt% sodium carboxymethyl cellulose, or the like. The inventors have found that such thixotropic agents can provide an excellent balance between sprayability and lubricity, avoiding the need for significant amounts of humectants. Preferably, the thixotropic agent is composed of a combination of one or more celluloses and one or more carboxyalkyl cellulose alkali metals, or more preferably, a combination of microcrystalline cellulose and sodium carboxymethyl cellulose.

[0027] Preferably, the thixotropic agent is present in the composition in the following amounts: i) at least 1% by weight, at least 2% by weight, at least 3% by weight, at least 3.1% by weight, at least 3.2% by weight, at least 3.3% by weight, at least 3.4% by weight, at least 3.5% by weight, at least 3.6% by weight, at least 3.7% by weight, or at least 3.8% by weight; and / or ii) at most 10% by weight, at most 9% by weight, at most 8% by weight, at most 7% by weight, at most 6% by weight, at most 5% by weight, at most 4% by weight, at most 3.9% by weight, at most 3.8% by weight, at most 3.7% by weight, at most 3.6% by weight, at most 3.5% by weight, at most 3.4% by weight, or at most 3.3% by weight. In one embodiment, it accounts for 1 to 10% by weight of the composition, more preferably 2 to 5% by weight, and most preferably 2 to 4% by weight. The upper limit of 10% by weight avoids the formation of high viscosity, which hinders spraying with conventional equipment.

[0028] The compositions of the present invention further comprise a humectant. Preferably, the composition comprises less than 25% by weight of a humectant, more preferably less than 20% by weight, or up to 15%, 10%, or 9% by weight of a humectant. It should be understood that in these embodiments, when two or more humectants are present, the total amount of the humectant is less than the amounts described above. Most preferably, the composition comprises at least 2% by weight of a humectant, more preferably at least 3%, at least 4%, at least 5%, at least 6%, or at least 7% by weight of a humectant. In one embodiment, it comprises 5 to 15% by weight of a humectant, or 7 to 9% by weight of a humectant. Preferably, the humectant is selected from glycerin, propylene glycol (1,2-propanediol), 1,3-propanediol, polyethylene glycol, and combinations thereof, and more preferably from glycerin, propylene glycol, and combinations thereof.

[0029] The compositions illustrated in US 2007 / 0059250 and US 2007 / 059266 use high levels of humectants, particularly glycerin and / or propylene glycol, to ensure good sprayability and lubricity. In this invention, a combination of one or more celluloses and one or more carboxyalkyl cellulose alkali metals is included, which allows for good sprayability and lubricity while still containing humectants, but at a lower level. This, in turn, provides the opportunity to produce compositions with low stoichiometric concentrations in accordance with the aforementioned WHO guidelines.

[0030] Preferably, the moisturizer is a combination of glycerin and propylene glycol (1,2-propanediol), more preferably, wherein glycerin and propylene glycol are present in a weight ratio of 2:3 to 3:2. The inventors have discovered that this ratio of glycerin to propylene glycol provides an excellent skin feel to the lubricant. Most preferably, glycerin and propylene glycol are present in a weight ratio of about 1:1.

[0031] The preferred weight ratio of humectant to thixotropic agent is less than 4:1, more preferably 2:1 to 3:1. In these embodiments, the humectant is preferably a combination of glycerin and propylene glycol.

[0032] Preferably, the weight molality of the composition is less than 1200 mOsm / kg, more preferably 1000 to 1100 mOsm / kg. Preferably, the weight molality is determined using the methods described in United States Pharmacopeia (USP) Reference Standard 785, particularly USP 43-NF38 (the contents of which are incorporated herein by reference).

[0033] Preferably, the composition is subjected to a temperature of 25°C and a time of 10 seconds. -1 The viscosity at the shear rate is at least 800 mPa·s, more preferably 1000 to 1500 mPa·s. Preferably, the composition is at a temperature of 25°C and a viscosity of 1000 s. -1 The viscosity at the shear rate is 100 to 600 mPa·s, more preferably 200 to 500 mPa·s. It should be understood that these values ​​refer to the viscosity of the composition before spraying.

[0034] Preferably, the composition is subjected to a temperature of 25°C and 10 s after spraying. -1 The viscosity at the shear rate is at least 400 mPa·s, more preferably 500 to 800 mPa·s. Preferably, the composition is subjected to a temperature of 25°C and 1000 s after spraying. -1 The viscosity at the shear rate is 100 to 600 mPa·s, more preferably 200 to 500 mPa·s. Preferably, the spraying is carried out under the conditions described herein.

[0035] It has been found that combinations comprising one or more cellulose molecules and one or more carboxyalkyl cellulose alkali metals can provide compositions that exhibit high thixotropic properties at low shear rates (e.g., 10 s⁻¹). -1 The viscosity measured at the specified conditions was lower after spraying than before spraying, but remained lower at higher shear rates (e.g., 1000 s⁻¹). -1 The viscosity measured at 25°C is maintained after spraying. Therefore, in some embodiments, the viscosity of the composition disclosed herein after spraying is at most 80%, preferably at most 60%, of the viscosity before spraying, wherein the viscosity after spraying and the viscosity before spraying are measured at 25°C and 10 s. -1 The viscosity was measured at a shear rate of [missing value]. Furthermore, in some embodiments, the viscosity of the composition disclosed herein after spraying is at least 90%, preferably 90 to 100%, of the viscosity before spraying, wherein the viscosity after spraying and the viscosity before spraying are measured at a temperature of 25°C and 1000 s [missing value]. -1The measurements were taken at the shear rate. Preferably, the spraying was carried out under the conditions described herein.

[0036] Preferably, the viscosity values ​​described herein are measured using a Discovery Series Hybrid rheometer (DHR2, TA Instruments) equipped with a 40 mm 1° cone measuring system.

[0037] Advantageously, the compositions of the present invention can have relatively high resting viscosity (i.e., before and after spraying), meaning that once applied to the target area, the composition forms a non-drip, non-soiling layer that does not migrate or spread. Despite the high resting viscosity, the composition is sprayable because the thixotropic agent causes the composition to exhibit a significantly reduced apparent viscosity when subjected to shear forces. In other words, the composition has low viscosity under high shear conditions.

[0038] Lubricity can be quantified using the coefficient of friction value determined by tribological measurements. The coefficient of friction is inversely proportional to the lubricity of a product and is referred to as "relative lubricity." Relative lubricity can be calculated from the coefficient of friction data by dividing the number 1 by the corresponding coefficient of friction value. Preferably, when measured using the tribological testing method described in the examples, the composition of the present invention provides a coefficient of friction of at least 0.05, more preferably 0.06 to 0.15 at a sliding speed of 10,000 μm / s. It should be understood that these values ​​refer to the lubricity of the composition before spraying. Preferably, when measured using the tribological testing method described in the examples, the composition after spraying provides a coefficient of friction of 0.05 to 0.15, more preferably 0.06 to 0.15 at a sliding speed of 10,000 μm / s. Preferably, the coefficient of friction after spraying is within 20%, more preferably within 10%, of the coefficient of friction before spraying. Therefore, the composition of the present invention maintains high lubricity even after spraying. Preferably, the spraying is performed under the conditions described herein.

[0039] Preferably, the composition is aqueous. Preferably, the composition contains at least 60% by weight of water, more preferably at least 65% by weight, and more preferably 70 to 95% by weight of water.

[0040] Preferably, the pH of the composition is 3.0 to 5.0, more preferably 3.5 to 4.5, more preferably 4.0 to 4.3, and most preferably about 4.2. This pH is suitable for the vaginal area. Furthermore, the inventors have discovered that in embodiments where the thixotropic agent is a combination of microcrystalline cellulose and sodium carboxymethyl cellulose, the resting viscosity of the composition is at its maximum at a given thixotropic agent concentration when the pH is within this range. The composition may contain a pH adjuster, such as sodium hydroxide, to bring the pH within the desired range.

[0041] In some embodiments, the composition contains a buffer. Suitable buffers for this invention include, for example, lactic acid / sodium lactate. However, preferably, the composition does not contain a buffer. This means less impact on skin pH.

[0042] Preferably, the composition comprises a preservative, preferably selected from benzoic acid, p-hydroxybenzoic acid, potassium sorbate, sodium benzoate, phenoxyethanol, and combinations of two or more thereof. Preferably, the preservative is present in an amount of 0.05 to 5% by weight of the composition, more preferably 0.1 to 1% by weight.

[0043] Preferably, the composition does not contain any pharmaceutically active ingredient. Preferably, the composition does not contain any nonsteroidal anti-inflammatory drugs (NSAIDs), such as flurbiprofen, ketoprofen, or diclofenac, or pharmaceutically acceptable salts thereof. Preferably, the composition does not contain any pharmaceutically active ingredients of resorcinol, benzocaine, dextromethorphan, menthol lidocaine, pentyl-m-cresol, or 2,4-dichlorobenzyl alcohol, or pharmaceutically acceptable salts thereof.

[0044] In a particularly preferred embodiment, a personal lubricant composition is provided, comprising 2 to 5% by weight of a thixotropic agent and 5 to 15% by weight of a humectant.

[0045] The thixotropic agent is a combination of one or more cellulose molecules and one or more carboxyalkyl cellulose alkali metals.

[0046] The moisturizer is a combination of glycerin and propylene glycol.

[0047] The glycerol and propylene glycol are present in a weight ratio of 3:2 to 2:3, and

[0048] The composition has a weight molar osmotic pressure concentration of less than 1200 mOsm / kg and a pH of 4.0 to 5.0.

[0049] According to a second aspect of the invention, a pump-type spray device or a squeeze-type spray bottle is provided, which contains the personal lubricant composition described in the first aspect of the invention.

[0050] According to a third aspect of the invention, a method for providing personal lubricant is provided, the method comprising dispensing a personal lubricant composition of the first aspect of the invention to a target area, preferably from a pump-type spray device or a squeeze-type spray bottle. In one embodiment, the method is a method for providing lubrication during sexual activity. In one embodiment, the target area is on the human body, preferably the genital or anal region, preferably the vagina, vaginal area, or penis. Preferably, the target area does not include the cervix.

[0051] According to a fourth aspect, the use of the personal lubricant composition of the first aspect of the invention for providing lubrication during sexual activity is provided. Attached Figure Description

[0052] Embodiments of the invention will now be described in conjunction with the following non-limiting drawings, in which:

[0053] Figure 1 This is a graph showing the viscosity of the personal lubricant of the present invention as a function of shear rate, according to Examples 1 and 2. The y-axis represents viscosity in Pa·s, and the x-axis represents viscosity in s·s. -1 Shear rate in units of 1. Solid lines represent the viscosity of the lubricant before spraying (hollow and solid circles represent the first and second measurements, respectively). Dashed lines represent the viscosity of the lubricant after spraying (hollow and solid diamonds represent the first and second measurements, respectively).

[0054] Figure 2 This is a graph showing the measured coefficient of friction of the personal lubricant of the present invention as a function of sliding speed, according to Examples 1 and 3. The y-axis represents the coefficient of friction, and the x-axis represents the sliding speed in μm. Dashed lines represent the coefficient of friction of the lubricant before spraying (solid circles, squares, and rhombuses represent the first, second, and third measurements, respectively). Solid lines represent the coefficient of friction of the lubricant after spraying (hollow circles, squares, and rhombuses represent the first, second, and third measurements, respectively). Detailed Implementation

[0055] The invention will now be described in conjunction with the following non-limiting embodiments.

[0056] Example 1

[0057] Prepare a personal lubricant with the following composition:

[0058]

[0059] The composition was prepared by dispersing the thickener in deionized water under low shear. High shear was then applied to activate the thickener (colloid mill, maximum rpm, 3 to 10 minutes; homogenizer minimum 150 bar). After activation, the mixture was allowed to stand for 15 minutes. Propylene glycol, glycerol, and preservative were then dissolved in the liquid phase and mixed under moderate stirring. Finally, sodium hydroxide was added and the pH was measured.

[0060] The pH is 4.2, and the weight molality osmolality, measured according to reference standard 785 of USP43-NF38, is 1045.9 mOsm / kg. This product has the desired texture and feel against the skin, is non-sticky, and provides a very pleasant sensation during sexual activity.

[0061] Example 2

[0062] The viscosity of the composition in Example 1 was measured at 25°C before and after spraying using a research rheometer (DHR2, TA Instruments) equipped with a 40 mm 1° cone measuring system. A solvent trap cap was used to minimize drying of the sample at the exposed edges. After equilibration at 25°C for 30 s, the sample was exposed to a pre-shear for 30 s, followed by 10 s of... -1 Shear rate scan, 10 s -1 Up to 15000 s -1 Logarithmic scale, 8 points for every ten times the shear rate, shear applied for 30 s at each rate, and viscosity calculated in the last 5 seconds of each step.

[0063] The results are shown in Figure 1 The following table summarizes the key points:

[0064] Table 1: Viscosity Measurement

[0065]

[0066] Example 3

[0067] The tribological properties of the composition of Example 1 were determined before and after spraying using the same rheometer (DHR-2, TA Instruments) as used in Example 2, equipped with a custom-designed 3-sphere plate measurement system. Specifically, the tribological properties of the composition of Example 1 were determined as follows. A tribological assembly comprising the geometry of three glass hemispheres was used, sliding relative to a silicone substrate on which the sample had been laid, under a limited load of 1 N. The rotational angular velocity was increased from 0.05 rad / s to 20 rad / s at 8 points every tenfold, each point held for 20 s, and the coefficient of friction was averaged in the last 15 s. The substrate below was maintained at 32°C throughout. The test was performed in triplicate.

[0068] The results are shown in Figure 2 The following table summarizes the key points:

[0069]

[0070] Surprisingly, the inclusion of the thixotropic thickener described herein allows the composition to maintain its lubricity over a wide range of sliding speeds before and after spraying. This cannot be simply explained by viscosity, as the viscosity of the composition was already shown to decrease after spraying in Example 2 when measured at low shear rates.

[0071] Example 4

[0072] The tribological properties of the composition of Example 1 were compared with those of two existing commercial products (KY liquid and KY gel). The coefficient of friction was determined at 10000 μm / s without spraying, using the method described in Example 3. The results are listed in the table below:

[0073]

[0074] The composition of Example 1 has lubricity comparable to that of existing commercial personal lubricants, but it can be sprayed into a fine mist.

[0075] The above detailed description is provided by way of explanation and illustration and is not intended to limit the scope of the appended claims. Many variations of the presently preferred embodiments shown herein will be apparent to those skilled in the art and remain within the scope of the appended claims and their equivalents.

Claims

1. A sprayable personal lubricant composition comprising less than 25% by weight of a humectant and 1% to 10% by weight of a thixotropic agent, wherein, The thixotropic agent comprises i) a combination of one or more celluloses and ii) a combination of one or more carboxyalkyl cellulose alkali metals; The cellulose comprises microcrystalline cellulose but does not include cellulose ethers or cellulose esters; The composition is subjected to a temperature of 25°C and a spray time of 10 seconds before spraying. -1 The viscosity at the shear rate is 800 mPa·s to 1500 mPa·s; Wherein, the weight molar osmotic pressure concentration of the composition is less than 1200 mOsm / kg; The moisturizer is selected from the group consisting of glycerin, 1,2-propanediol, 1,3-propanediol and polyethylene glycol; Wherein, the alkyl group in the one or more carboxyalkyl cellulose alkali metals is selected from methyl, ethyl, propyl and butyl, and the alkali metal in the one or more carboxyalkyl cellulose alkali metals is selected from lithium, sodium and potassium.

2. The personal lubricant composition of claim 1, wherein, The humectant is 1,2-propanediol, glycerin, or a combination thereof.

3. The personal lubricant composition as claimed in claim 1 or 2, wherein, The composition was subjected to a temperature of 25°C and a spraying time of 1000 s before spraying. -1 The viscosity at the shear rate is 100 mPa·s to 600 mPa·s.

4. The personal lubricant composition of claim 1 or 2, wherein the weight molar osmotic pressure concentration of the composition is 1000 to 1100 mOsm / kg.

5. The personal lubricant composition as claimed in claim 1 or 2, wherein, The thixotropic agent comprises a combination of microcrystalline cellulose and sodium carboxymethyl cellulose.

6. The personal lubricant composition as claimed in claim 1 or 2, wherein, The thixotropic agent is present in an amount of 2% to 5% by weight of the composition.

7. The personal lubricant composition of claim 1 or 2, wherein the composition comprises a humectant in an amount of 5% to 15% by weight of the composition.

8. The personal lubricant composition of claim 2, wherein, The moisturizer is a combination of glycerin and 1,2-propanediol.

9. The personal lubricant composition of claim 8, wherein, The glycerol and 1,2-propanediol are present in a weight ratio of 3:2 to 2:

3.

10. The personal lubricant composition of claim 1 or 2, wherein the composition is heated to 25°C and cooled to a temperature of 10 s before spraying. -1 The viscosity at the shear rate is 1000 mPa·s to 1500 mPa·s.

11. The personal lubricant composition of claim 1 or 2, wherein the pH of the composition is 4.0 to 5.

0.

12. A sprayable personal lubricant composition comprising: i) a total amount of 5% to 15% by weight of glycerol and 1,2-propanediol; and ii) One or more cellulose and one or more carboxyalkyl cellulose alkali metals, in a total amount of 2% to 5% by weight; wherein, The cellulose comprises microcrystalline cellulose but does not include cellulose ether or cellulose ester; the alkyl group in the one or more carboxyalkyl cellulose alkali metals is selected from methyl, ethyl, propyl and butyl, and the alkali metal in the one or more carboxyalkyl cellulose alkali metals is selected from lithium, sodium and potassium; The glycerol and 1,2-propanediol are present in a weight ratio of 3:2 to 2:

3. The composition has a weight molar osmotic pressure concentration of less than 1200 mOsm / kg and a pH of 4.0 to 5.

0. The composition is subjected to a temperature of 25°C and a spray time of 10 seconds before spraying. -1 The viscosity at the shear rate is 800 mPa·s to 1500 mPa·s.

13. A pump-type spray device comprising the personal lubricant composition according to any one of claims 1 to 12.

14. A non-therapeutic method for providing personal lubrication, the method comprising dispensing a personal lubricant composition according to any one of claims 1 to 12 to a target area.

15. The non-therapeutic method of claim 14, wherein the method comprises dispensing the personal lubricant composition from a pump-type spray device or a squeeze-type spray bottle to a target area.

16. A squeeze spray bottle comprising the personal lubricant composition according to any one of claims 1 to 12.

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