Blood cooling device and cooling method thereof

Abstract

The blood cooling device and method provided by the application comprise a constant-temperature module and a blood delivery pipeline arranged in the constant-temperature module. The constant-temperature module comprises a first constant-temperature block, a second constant-temperature block and a third constant-temperature block arranged in sequence. The temperature of the first constant-temperature block is controlled at 22-25 DEG C, the temperature of the second constant-temperature block is controlled at 10-15 DEG C, and the temperature of the third constant-temperature block is controlled at 0-4 DEG C. Blood is cooled by the first constant-temperature block, the second constant-temperature block and the third constant-temperature block from the inlet of the blood delivery pipeline and then flows out from the outlet of the blood delivery pipeline. The blood cooling device provided by the application can realize long-time treatment by controlling the blood heat exchange temperature difference in a reasonable range, thereby avoiding the problem of blood cell damage, and can be developed for the scene of first aid for acute ischemic stroke (AIS) patients and fully meet the clinical requirements.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of medical devices, in particular to a blood cooling device and a cooling method thereof. BACKGROUND

[0002] Brain ischemia caused by stroke (commonly known as stroke) is a major killer of human life and health safety worldwide. Stroke refers to a series of brain diseases caused by blood circulation disorders in the brain due to rupture or blockage of cerebral blood vessels. Stroke often occurs in the elderly population, and as the degree of population aging continues to increase, the incidence and mortality rates have increased significantly. In addition to high incidence and mortality, the disability rate of stroke is also high. Even if there is no death, the patients are likely to suffer from various serious sequelae, including paralysis, language disorders and behavior disorders, which greatly reduces the quality of life of patients.

[0003] Acute ischemic stroke (AIS) has a high mortality and disability rate, and reperfusion injury occurs after intravenous thrombolysis or mechanical thrombectomy treatment. There is no effective neuroprotective drug, and the clinical prognosis is poor. Clinical studies have shown that mild hypothermia therapy is the most promising neuroprotective method. Timely brain cooling measures in the early stage of the disease can save patients' lives and significantly improve patients' prognosis. At the same time, due to the characteristics of acute onset, severe onset, and rapid change, the response speed of emergency equipment often becomes a key factor affecting the treatment effect.

[0004] At present, 4-10℃ low temperature is the preferred temperature for perfusion in many vascular surgery operations, but local low temperature solution perfusion can easily lead to low hemolysis and increased intracranial pressure, which can easily induce heart failure and brain edema, and it is difficult to accurately control the temperature for a long time. The autologous blood transfusion technology based on targeted hypothermia has become the best treatment plan due to its significant effect and small side effects.

[0005] To achieve the above-mentioned goal, it is necessary to have a device that can safely and quickly cool blood. However, there is no device in the field of brain nerve treatment that meets the technical specifications. In the commercialized medical devices, the closest one is the blood heat exchange module in extracorporeal membrane oxygenation (ECMO), but its original design is not intended for rapid blood cooling, and it cannot meet the first aid requirements of acute ischemic stroke (AIS) patients. SUMMARY

[0006] In view of this, it is necessary to provide a blood cooling device and a cooling method thereof that can meet the first aid requirements of acute ischemic stroke (AIS) patients in view of the defects in the prior art.

[0007] To solve the above problems, the technical scheme adopted by the present application is as follows:

[0008] The application provides a blood cooling device, comprising a constant temperature module and a blood delivery pipeline arranged in the constant temperature module, wherein the constant temperature module comprises a first constant temperature block, a second constant temperature block and a third constant temperature block arranged in sequence, the temperature of the first constant temperature block is controlled at 22-25 DEG C, the temperature of the second constant temperature block is controlled at 10-15 DEG C, and the temperature of the third constant temperature block is controlled at 0-4 DEG C; blood is cooled by the first constant temperature block, the second constant temperature block and the third constant temperature block from the inlet of the blood delivery pipeline and then flows out from the outlet of the blood delivery pipeline.

[0009] In some embodiments, the outer side of any of the constant temperature blocks is a plane, and the inner side is provided with a spiral groove, and the blood delivery pipeline is in the form of a spiral coil embedded in the groove.

[0010] In some embodiments, any of the constant temperature blocks is a hexagonal column.

[0011] In some embodiments, the blood delivery pipeline is made of medical grade 316L stainless steel.

[0012] In some embodiments, the outer side of any of the constant temperature blocks is attached with a semiconductor refrigeration sheet.

[0013] In some embodiments, the outer side of the semiconductor refrigeration sheet is provided with a heat dissipation fin.

[0014] In some embodiments, the application further comprises a shell, and the constant temperature module, the blood delivery pipeline, the semiconductor refrigeration sheet and the heat dissipation fin are all accommodated in the shell, and the shell and the heat dissipation fin form a heat dissipation channel.

[0015] In some embodiments, the application further comprises a fan arranged in the shell, and the fan can extract hot air in the shell.

[0016] In some embodiments, any of the constant temperature blocks is further provided with a temperature measuring device.

[0017] In addition, the application further provides a cooling method of the blood cooling device, which comprises the following steps.

[0018] Blood is cooled by the first constant temperature block, the second constant temperature block and the third constant temperature block from the inlet of the blood delivery pipeline and then flows out from the outlet of the blood delivery pipeline.

[0019] The application has the following beneficial effects.

[0020] The blood cooling device and method provided by the application comprises a constant temperature module and a blood delivery pipeline arranged in the constant temperature module, the constant temperature module comprises a first constant temperature block, a second constant temperature block and a third constant temperature block arranged in sequence, the temperature of the first constant temperature block is controlled at 22-25 DEG C, the temperature of the second constant temperature block is controlled at 10-15 DEG C, and the temperature of the third constant temperature block is controlled at 0-4 DEG C, blood is cooled by the first constant temperature block, the second constant temperature block and the third constant temperature block from the inlet of the blood delivery pipeline and then flows out from the outlet of the blood delivery pipeline, the blood cooling device provided by the application controls the heat exchange temperature difference of blood within a reasonable range through the segmented and step-by-step cooling mode, so as to avoid the problem of blood cell damage, thereby realizing long-time treatment (low-temperature physiological saline perfusion for a long time is easy to cause heart failure and brain edema, as long as the blood safety is ensured, the self-blood perfusion does not have this problem), and the blood cooling device can be developed for the scene of first aid for acute ischemic stroke (AIS) patients and fully meet the clinical requirements. BRIEF DESCRIPTION OF DRAWINGS

[0021] In order to more clearly illustrate the technical solutions of the embodiments of the application, the following will briefly introduce the drawings needed to be used in the description of the embodiments of the application or the prior art. Obviously, the drawings described below are only some embodiments of the application, and other drawings can be obtained by those skilled in the art without creative effort on the basis of these drawings.

[0022] Figure 1 The structural principle diagram of the blood cooling device provided by the application.

[0023] Figure 2 The structural schematic diagram of the blood cooling device provided by the application. DETAILED DESCRIPTION

[0024] The embodiments of the application will be described in detail below, and examples of the embodiments are shown in the drawings, wherein the same or similar reference signs represent the same or similar elements or elements having the same or similar functions throughout. The embodiments described below by referring to the drawings are exemplary and are intended to explain the application, and cannot be understood as a limitation of the application.

[0025] In the description of the application, it should be understood that the terms "upper", "lower", "horizontal", "inner", "outer" and the like indicate the orientation or positional relationship shown in the drawings, and are only for the purpose of facilitating the description of the application and simplifying the description, and do not indicate or imply that the devices or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, therefore cannot be understood as a limitation of the application.

[0026] In addition, the terms "first", "second", etc. are used only for descriptive purposes and are not to be construed as indicating or implying relative importance or an indicated number of technical features. Thus, features defined with "first", "second" can explicitly or implicitly include one or more of the features. In the description of the present application, the meaning of "a plurality of" is two or more, unless otherwise explicitly and specifically limited.

[0027] In order to make the purpose, technical solutions and advantages of the present application more clear, the present application is further described in detail below in combination with the drawings and examples.

[0028] Please refer to Figure 1 and Figure 2 A blood cooling device provided for the present embodiment includes a constant temperature module 10, a blood delivery pipeline 20, a semiconductor refrigeration sheet 30, a heat dissipation sheet 40, a shell 50 and a fan 60. The specific implementation scheme of each specific component is described in detail below.

[0029] The constant temperature module 10 includes a first constant temperature block 11, a second constant temperature block 12 and a third constant temperature block 13 arranged in sequence, the temperature of the first constant temperature block is controlled at 22-25℃, the temperature of the second constant temperature block is controlled at 10-15℃, and the temperature of the third constant temperature block is controlled at 0-4℃.

[0030] It can be understood that too fast cooling speed is easy to cause cell damage, in order to ensure the safety of blood, the heat exchange temperature difference of the heat exchange surface must be controlled within a certain value, usually 10-20℃, therefore, the design of multi-stage heat exchange is adopted, the constant temperature blocks are arranged according to a certain temperature gradient, and the constant temperature blocks are adiabatically treated to avoid mutual influence; at the same time, because the temperature of human blood is basically constant, considering 37℃, then the ideal temperature gradient of the constant temperature blocks is 22℃-7℃-0℃, and the blood temperature gradient is 37℃-25℃-10℃-4℃, therefore, the above temperature ranges are set to ensure the safety of blood.

[0031] In the present embodiment, any one of the constant temperature blocks (11, 12 and 13) is selected from materials with as small heat capacity as possible and high thermal conductivity, so as to reduce the overall heat capacity of the system and reduce the temperature control lag problem, such as aluminum or copper.

[0032] The blood delivery pipeline 20 is arranged in the constant temperature module. The blood flows out from the outlet of the blood delivery pipeline after being cooled by the first constant temperature block 11, the second constant temperature block 12 and the third constant temperature block 13 through the inlet of the blood delivery pipeline 20.

[0033] In the present embodiment, any one of the constant temperature blocks (11, 12 and 13) is in a cylindrical structure, the outer side is a plane, and the inner side is provided with a spiral groove, and the blood delivery pipeline 20 is in a spiral coil shape and is embedded in the groove.

[0034] It can be understood that the blood delivery pipeline 20 adopts a single seamless stainless steel spiral pipe structure and is made of medical-grade 316L stainless steel with an EP-grade finish, so that the material in direct contact with the blood has good biocompatibility, the blood flowing through the channel is as smooth as possible and has no dead corners, dead zones or welds, thereby reducing the risk of blood clotting.

[0035] In this embodiment, the outer side of any of the constant temperature blocks is attached with a semiconductor refrigeration sheet 30.

[0036] Further, the semiconductor refrigeration sheet 30 can be selected from models such as 12706, 12708, 12710 and 12712, depending on the blood flow and target temperature.

[0037] It can be understood that the semiconductor refrigeration sheet 30 is usually in the form of a sheet, and in order to effectively transfer the cold to the spiral pipe, the outer side of any of the constant temperature blocks is flat so as to have good thermal contact with the semiconductor refrigeration sheet, and the inner side is provided with a spiral groove so as to have good thermal contact with the blood delivery pipeline 20.

[0038] Further, the refrigeration capacity of a single semiconductor refrigeration sheet is limited, and in practice, a multi-piece combination process can also be used to obtain a cold capacity of more than 100 W (under the condition of temperature difference).

[0039] It can be understood that the semiconductor refrigeration sheet 30 is used for refrigeration in the present application, and due to the fast start-up characteristic of semiconductor refrigeration, each constant temperature block can reach the target temperature within 1 min after power-on, and the start-up time of the whole machine is not more than 3 min; sometimes it is necessary to heat the blood during the treatment process in order to quickly restore the body temperature, and due to the characteristics of semiconductor refrigeration, the cold and hot ends of the refrigeration sheet can be switched by simply changing the current direction; and the semiconductor refrigeration can control the cold capacity through precise electrical signal control, thereby realizing precise temperature control.

[0040] Further, any of the constant temperature blocks is a hexagonal column. It can be understood that in practice, it is not limited to a hexagonal column, and only needs to satisfy that the outer side is flat so as to have good thermal contact with the semiconductor refrigeration sheet 30, thereby achieving a better effect.

[0041] It can be understood that the blood delivery pipeline 20 is arranged in the present application in the form of a stainless steel spiral coil embedded in the spiral groove, forming good contact, and through this ingenious design, the cold capacity generated by the cold end of the semiconductor refrigeration sheet 30 is transmitted to the blood through the constant temperature module 10 and the blood delivery pipeline 20.

[0042] In this embodiment, the outer side of the semiconductor refrigeration sheet 30 is mounted with a heat sink 40.

[0043] It can be understood that the semiconductor refrigeration sheet 30 and the heat dissipation sheet 40 jointly constitute a refrigeration device 41, further improving the heat dissipation effect.

[0044] In the embodiment, the constant temperature module 10, the blood delivery pipeline 20, the semiconductor refrigeration sheet 30 and the heat dissipation sheet 40 are all accommodated in the shell 50, and the shell 50 and the heat dissipation sheet 40 constitute a heat dissipation channel, further improving the heat dissipation effect.

[0045] In the embodiment, the fan 60 is arranged at the bottom of the shell 50 and draws air from inside to outside, so as to take away the heat generated by the hot end of the refrigeration sheet.

[0046] In the embodiment, the constant temperature block is further provided with a temperature measuring device, so that real-time temperature data can be fed back to control and adjust the power of the refrigeration device.

[0047] The blood cooling device and the blood cooling method provided by the application can control the blood heat exchange temperature difference within a reasonable range through the segmented and step-by-step cooling mode, so as to avoid the problem of blood cell damage, and thus long-time treatment can be realized (low-temperature physiological saline perfusion for a long time is easy to cause heart failure and brain edema, as long as the blood safety is ensured, autologous blood perfusion does not have this problem), and the application can be developed for the scene of first aid for acute ischemic stroke (AIS) patients, and fully meets the clinical needs.

[0048] The above technical solutions of the application will be described in detail in combination with specific embodiments.

[0049] Embodiment 1

[0050] The blood cooling device provided by the above embodiment of the application is designed with a blood flow of 100 mL / min, and blood is sent into the cooling device through the blood inlet A of the blood delivery pipeline 20, exchanges heat with the first constant temperature block 11, the second constant temperature block 12 and the third constant temperature block 13, and finally the temperature is reduced to 4-10℃ after three-stage cooling, and then the blood is sent out of the device from the blood outlet B.

[0051] The blood inlet temperature of the first constant temperature block 11 is 37℃, the temperature of the first constant temperature block 11 is controlled at 22℃, the temperature difference between the two is controlled at 15℃, and the blood outlet temperature is about 25℃.

[0052] The blood inlet temperature of the second constant temperature block 12 is 25℃, the temperature of the second constant temperature block 12 is controlled at 12℃, the temperature difference between the two is controlled at 13℃, and the blood outlet temperature is about 15℃.

[0053] The blood inlet temperature of the third constant temperature block 13 is 15℃, the temperature of the third constant temperature block 13 is controlled at 2℃, the temperature difference between the two is controlled at 13℃, and the blood outlet temperature is about 4-5℃.

[0054] The speed of the fan is controlled by the temperature of the air exiting the outlet, and heat is removed in time.

[0055] The above merely describes the preferred embodiments of the present application, and only the technical principles of the present application are described in detail. These descriptions are only intended to explain the principles of the present application, and cannot be interpreted in any way as a limitation on the protection scope of the present application. Based on the explanations herein, any modifications, equivalent replacements and improvements made within the spirit and principles of the present application, and other specific embodiments of the present application that can be conceived by those skilled in the art without creative labor, should be included in the protection scope of the present application.

Claims

1. A blood cooling device, characterized by, The constant temperature module and the blood delivery pipeline arranged in the constant temperature module, the constant temperature module comprises a first constant temperature block, a second constant temperature block and a third constant temperature block arranged in sequence, the temperature of the first constant temperature block is controlled at 22-25 DEG C, the temperature of the second constant temperature block is controlled at 10-15 DEG C, the temperature of the third constant temperature block is controlled at 0-4 DEG C, blood is cooled by the first constant temperature block, the second constant temperature block and the third constant temperature block from the inlet of the blood delivery pipeline and then flows out from the outlet of the blood delivery pipeline; The outer side of any constant temperature block is a plane, and the inner side is provided with a spiral groove, and the blood delivery pipeline is embedded in the groove in a spiral coil shape; Any constant temperature block is a hexagonal column; The outer side of any constant temperature block is provided with a semiconductor refrigeration sheet, and the outer side of the semiconductor refrigeration sheet is provided with a cooling fin; The constant temperature module, the blood delivery pipeline, the semiconductor refrigeration sheet and the cooling fin are all accommodated in the shell, and the shell and the cooling fin form a cooling channel; The fan is arranged in the shell, and the fan can extract hot air in the shell.

2. The blood cooling device of claim 1, wherein The blood delivery pipeline is made of medical grade 316L stainless steel.

3. The blood cooling device of claim 1, wherein Any constant temperature block is further provided with a temperature measuring device.

4. A method of cooling according to any one of claims 1 to 3, wherein, The method comprises the following steps: Blood is cooled by the first constant temperature block, the second constant temperature block and the third constant temperature block from the inlet of the blood delivery pipeline and then flows out from the outlet of the blood delivery pipeline.

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