A collision reaction cell with no charge accumulation and mass spectrometer

Abstract

The application discloses a collision reaction cell without charge accumulation, and belongs to the field of mass spectrum analysis, which comprises a collision cell main body and two transition ends, the two transition ends are respectively installed at two ends of the collision cell main body, the collision cell main body comprises an insulating cylinder and a main quadrupole rod installed on the insulating cylinder, the insulating cylinder comprises a cylinder body and a conductive ring located at the end of the cylinder body, the inner side of the cylinder body is provided with a conductive plating layer, the conductive plating layer extends to the conductive ring, the transition end comprises a conductive end cover and a conductive sealing ring, the conductive end cover is connected with the insulating cylinder, and the conductive sealing ring is located between the conductive end cover and the conductive ring; the charge in the insulating cylinder is guided to the conductive end cover through the conductive plating layer, the conductive ring and the conductive sealing ring; the conductive end cover can be grounded to guide the charge out; through the above design, the charge escaping to the inner wall of the insulating cylinder is guided to the conductive end cover and guided out, so that the charge accumulation in the collision cell caused by the escaped ions is avoided, and the ion transmission efficiency is improved.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of mass spectrometry, in particular to a collision reaction cell without charge accumulation and a mass spectrometer comprising the same. BACKGROUND

[0002] Triple quadrupole mass spectrometer uses three-stage quadrupole rods in series to analyze ion structure, the first-stage quadrupole rod (Q1) selects the required parent ion according to the set voltage scanning. The second-stage quadrupole rod (Q2) is called a collision reaction cell, which introduces collision or reaction gas to make the parent ion stream collide with the collision gas to form fragment ions through collision fragmentation or chemical reaction. The third-stage quadrupole rod (Q3) judges the parent ion configuration according to the scanning results of the fragment ions. The collision reaction cell is an important technology for removing interference in mass spectrometers.

[0003] Because the two ends of the quadrupole rod electrode and other electrodes form an edge electric field distribution, this edge field reduces the ion introduction efficiency and mass resolution of the quadrupole rod electrode, so a pre-quadrupole rod is arranged as a transition before each quadrupole rod. The collision reaction cell is at the second stage of the triple quadrupole rod, and a set of pre-quadrupole rods and ion lenses are installed at the ion inlet end and outlet end of the collision reaction cell for focusing ions and differential vacuum.

[0004] The existing collision reaction cell uses part of the ions to oscillate in the quadrupole rod and fly out of the quadrupole field to hit the insulating sleeve, and the charge accumulates on the inner wall of the insulating sleeve to form a new electric field affecting the ion transmission efficiency. SUMMARY

[0005] In order to overcome the shortcomings of the prior art, one of the purposes of the present application is to provide a collision reaction cell which can avoid the influence of ion transmission efficiency caused by charge accumulation due to escaped ions.

[0006] In order to overcome the shortcomings of the prior art, the second purpose of the present application is to provide a mass spectrometer which can avoid the influence of ion transmission efficiency caused by charge accumulation due to escaped ions.

[0007] One of the purposes of the present application is achieved by adopting the following technical solutions:

[0008] The application discloses a collision reaction cell without charge accumulation, which comprises a collision cell main body and two transition ends, the two transition ends are respectively arranged at two ends of the collision cell main body, the collision cell main body comprises an insulating cylinder and a main quadrupole rod arranged on the insulating cylinder, the insulating cylinder comprises a cylinder body and a conductive ring arranged at an end of the cylinder body, an inner side of the cylinder body is provided with a conductive coating, the conductive coating extends to the conductive ring, the transition end comprises a conductive end cover and a conductive sealing ring, the conductive end cover is connected with the insulating cylinder, the conductive sealing ring is arranged between the conductive end cover and the conductive ring, and charges in the insulating cylinder are guided to the conductive end cover through the conductive coating, the conductive ring and the conductive sealing ring; and the conductive end cover can be grounded to guide the charges out.

[0009] Further, the transition end further comprises a support and a pre-quadrupole rod, the pre-quadrupole rod is arranged on the support, the support is made of an insulating material, and the support is provided with a hollow groove, so that the hollow groove reduces adhesion of escaped ions to the support.

[0010] Further, the support is provided with a first mounting hole, the transition end further comprises a first connecting column, the first connecting column is arranged in the first mounting hole and connected with the pre-quadrupole rod, so that the pre-quadrupole rod is arranged on the support.

[0011] Further, the support is arranged on the conductive end cover.

[0012] Further, the conductive end cover is provided with a mounting groove, the transition end further comprises an anti-rotation block, the anti-rotation block is fixed on the support, the anti-rotation block is arranged in the mounting groove, and the anti-rotation block prevents the support from rotating circumferentially relative to the conductive end cover.

[0013] Further, the conductive end cover is provided with a positioning groove, the support is provided with a fixing hole, the transition end further comprises a cylindrical pin, the cylindrical pin is arranged in the positioning groove and extends into the fixing hole, and the cylindrical pin prevents the support from moving axially relative to the conductive end cover.

[0014] Further, the positioning groove is in an L shape.

[0015] Further, the transition end further comprises a lens pole piece, the lens pole piece comprises a terminal, the lens pole piece is arranged between the support and the conductive end cover, and the terminal extends from the conductive end cover.

[0016] Further, the conductive end cover is provided with a threaded hole, the cylinder body is provided with a tapered hole, a fastener extends into the threaded hole and the tapered hole, so that the cylinder body and the conductive end cover are fixed.

[0017] The second purpose of the application is achieved by the following technical scheme.

[0018] A mass spectrometer comprising the charge-accumulation-free collision reaction cell of any of the preceding claims.

[0019] Compared with the prior art, the insulating cylinder of the charge-accumulation-free collision reaction cell of the application comprises a cylinder body and a conductive ring at the end of the cylinder body, the inner side of the cylinder body is provided with a conductive plating layer, the conductive plating layer extends to the conductive ring, the transition end comprises a conductive end cover and a conductive sealing ring, the conductive end cover is connected with the insulating cylinder, the conductive sealing ring is located between the conductive end cover and the conductive ring, the charge inside the insulating cylinder is guided to the conductive end cover through the conductive plating layer, the conductive ring and the conductive sealing ring, the conductive end cover can be grounded to guide the charge out, in addition, the support is provided with a hollow groove, the hollow groove reduces the adhesion of the escaped ions to the support, through the above design, the charge escaped to the inner wall of the insulating cylinder is guided to the conductive end cover and guided out, the accumulation of the charge in the collision cell caused by the escaped ions is avoided, and the ion transmission efficiency is improved. BRIEF DESCRIPTION OF DRAWINGS

[0020] Figure 1 It is a perspective view of the charge-accumulation-free collision reaction cell of the application;

[0021] Figure 2 It is Figure 1 an exploded view of the charge-accumulation-free collision reaction cell of the application;

[0022] Figure 3 It is Figure 2 a partial structure schematic view of the transition end of the charge-accumulation-free collision reaction cell of the application;

[0023] Figure 4 It is Figure 3 a perspective view of the support of the transition end of the application;

[0024] Figure 5 It is Figure 3 a perspective view of the conductive end cover of the transition end of the application;

[0025] Figure 6 It is Figure 2 a perspective view of the collision cell body of the charge-accumulation-free collision reaction cell of the application;

[0026] Figure 7 It is Figure 6 a perspective view of the insulating cylinder of the collision cell body of the application;

[0027] Figure 8 It is Figure 1 a partial structure perspective sectional view of the charge-accumulation-free collision reaction cell of the application.

[0028] In the figure: 10, transition end; 11, support; 110, hollow groove; 111, fixing hole; 112, first mounting hole; 113, mounting part; 12, lens pole piece; 120, terminal; 13, first sealing ring; 14, pre-quadrupole rod; 15, first connecting column; 16, anti-rotation block; 17, conductive end cover; 170, mounting groove; 171, positioning groove; 172, threaded hole; 18, cylindrical pin; 19, conductive sealing ring; 20, collision cell main body; 21, insulating cylinder; 210, cylinder body; 2101, conductive plating layer; 2102, conical hole; 2103, second mounting hole; 211, conductive ring; 22, main quadrupole rod; 23, second connecting column. DETAILED DESCRIPTION

[0029] The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only some of the embodiments of the present application, but not all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative work fall within the scope of protection of the present application.

[0030] It should be noted that when a component is referred to as being "fixed" to another component, it can be directly on the other component or can be fixed thereto through another intermediate component. When a component is referred to as being "connected" to another component, it can be directly connected to the other component or can be connected thereto through another intermediate component. When a component is referred to as being "disposed" on another component, it can be directly disposed on the other component or can be disposed thereon through another intermediate component. The terms "vertical", "horizontal", "left", "right", and similar expressions used herein are for illustrative purposes only.

[0031] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. The terminology used in the description of the application herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the application. As used herein, the term "and / or" includes any and all combinations of one or more of the associated listed items.

[0032] Figures 1 to 8 A schematic view of a collision reaction cell without charge accumulation, the collision reaction cell without charge accumulation comprising two transition ends 10 and a collision cell main body 20, the two transition ends 10 being respectively located at opposite ends of the collision cell main body 20. Axes of the two transition ends 10 and the collision cell main body 20 are located on the same straight line.

[0033] Each transition end 10 comprises a support 11, a lens pole 12, a first sealing ring 13, a pre-quadrupole 14, a first connecting column 15, an anti-rotation block 16, a conductive end cover 17, a cylindrical pin 18 and a conductive sealing ring 19.

[0034] The support 11 is made of insulating material. In the embodiment, the support 11 is made of plastic. The support 11 is provided with hollow grooves 110, fixing holes 111, first mounting holes 112 and mounting portions 113. The mounting portions 113 are located between the hollow grooves 110, and the hollow grooves 110 are used to reduce the circumferential area of the support 11. The hollow grooves 110 reduce the area of the support 11 on which the escaping ions adhere. The first mounting holes 112 are used to fix the pre-quadrupole 14, and the fixing holes 111 prevent the support 11 from moving axially relative to the conductive end cover 17.

[0035] The lens pole 12 is mounted at the end of the support 11, and the lens pole 12 is provided with terminals 120 connected to external circuits to apply an electrostatic field.

[0036] The first sealing ring 13 is mounted between the lens pole 12 and the conductive end cover 17 to seal the lens pole 12.

[0037] The pre-quadrupole 14 is mounted on the mounting portion 113 of the support 11. Specifically, the number of the pre-quadrupole 14 is four, and the four pre-quadrupoles 14 are all mounted on the support 11.

[0038] The first connecting column 15 is used to fix the pre-quadrupole 14. The first connecting column 15 extends into the first mounting hole 112 to connect with the pre-quadrupole 14, so that the pre-quadrupole 14 is fixed to the support 11.

[0039] The anti-rotation block 16 is mounted in the mounting groove 170 of the conductive end cover 17, and the anti-rotation block 16 is fixed to the support 11 by fasteners, which can prevent the support 11 from rotating circumferentially relative to the conductive end cover 17.

[0040] The conductive end cover 17 is provided with a mounting groove 170, a positioning groove 171 and a threaded hole 172. The conductive end cover 17 is made of stainless steel and can conduct electricity. The mounting groove 170 and the positioning groove 171 are located at one end of the conductive end cover 17, and the threaded hole 172 is located at the other end of the conductive end cover 17. The mounting groove 170 is used to mount the anti-rotation block 16 and make the terminals 120 of the lens pole 12 extend out. The positioning groove 171 is used to prevent the support 11 from moving axially relative to the conductive end cover 17. The positioning groove 171 is L-shaped. The threaded hole 172 is used to fix the conductive end cover 17 and the insulating cylinder 21.

[0041] The cylindrical pin 18 is located in the positioning groove 171 and is fixed to the fixing hole 111 of the support 11. When the support 11 moves axially relative to the conductive end cover 17, the cylindrical pin 18 abuts against the edge of the positioning groove 171.

[0042] The conductive sealing ring 19 is located between the conductive end cover 17 and the conductive ring 211 of the insulating cylinder 21. The conductive sealing ring 19 conducts the electric charge on the conductive ring 211 to the conductive end cover 17, and in addition, the conductive sealing ring 19 forms a seal between the conductive end cover 17 and the insulating cylinder 21, so that the pressure difference between the inside and outside of the collision cell is formed.

[0043] The collision cell body 20 comprises the insulating cylinder 21, the main quadrupole rod 22 and the second connecting column 23.

[0044] The insulating cylinder 21 comprises a cylinder body 210 and two conductive rings 211, and the two conductive rings 211 are respectively fixed to the two ends of the cylinder body 210. The cylinder body 210 is made of insulating material, and in this application, the cylinder body 210 is made of ceramic. The inside of the cylinder body 210 is provided with a conductive plating layer 2101, and the conductive plating layer 2101 extends from one end of the cylinder body 210 to the other end. The cylinder body 210 is provided with a tapered hole 2102 and a second mounting hole 2103, and the second mounting hole 2103 is used to mount the second connecting column 23. The tapered hole 2102 fixes the insulating cylinder 21 and the conductive end cover 17.

[0045] The main quadrupole rod 22 is installed inside the insulating cylinder 21. Specifically, the number of the main quadrupole rod 22 is four, and the four main quadrupole rods 22 are installed in parallel inside the insulating cylinder 21.

[0046] The number of the second connecting column 23 corresponds to or is a multiple of the number of the main quadrupole rod 22. Each second connecting column 23 extends into the second mounting hole 2103 and is connected with the main quadrupole rod 22, so that the main quadrupole rod 22 is installed inside the insulating cylinder 21.

[0047] When the collision reaction cell without charge accumulation is assembled, the outer edge of the lens pole piece 12 is clamped into the support 11, one side of the lens pole piece 12 is in contact with the insulating support 11, and the other side is in contact with the first sealing ring 13, and the sealing and insulation are completed at the same time. The terminal 120 is connected with the external circuit to apply the electrostatic field. The first connecting column 15 extends into the first mounting hole 112 and is connected with the pre-quadrupole rod 14, so that the pre-quadrupole rod 14 is fixed to the support 11. The anti-rotation block 16 is fixed to the support 11 by the fastener, which can prevent the support 11 from rotating relative to the conductive end cover 17. The cylindrical pin 18 is located in the positioning groove 171 and is fixed with the fixing hole 111 of the support 11. When the support 11 moves axially relative to the conductive end cover 17, the cylindrical pin 18 abuts against the edge of the positioning groove 171, preventing the support 11 from moving axially relative to the conductive end cover 17. The fastener passes through the threaded hole 172 and the tapered hole 2102 to fix the insulating cylinder 21 and the conductive end cover 17. The second connecting column 23 extends into the second mounting hole 2103 and is connected with the main quadrupole rod 22, so that the main quadrupole rod 22 is installed inside the insulating cylinder 21. The conductive sealing ring 19 is located between the conductive end cover 17 and the conductive ring 211 of the insulating cylinder 21. The conductive sealing ring 19 conducts the charge on the conductive ring 211 to the conductive end cover 17, and in addition, the conductive sealing ring 19 also forms a seal between the conductive end cover 17 and the insulating cylinder 21.

[0048] The present application reduces the circumferential area of the support 11 by providing the hollow groove 110 on the support 11, which reduces the area of the support 11 on which the escaped ions adhere. (Some ions directly escape from the hollow groove 110) The charge in the insulating cylinder 21 is guided to the conductive end cover 17 through the conductive plating layer 2101, the conductive ring 211 and the conductive sealing ring 19, and the conductive end cover 17 can be grounded to guide the charge out. Through the above design, the charge escaping to the inner wall of the insulating cylinder 21 is guided to the conductive end cover 17 and discharged, avoiding the accumulation of charge in the collision cell caused by the escaped ions, and improving the ion transmission efficiency.

[0049] The present application also relates to a mass spectrometer comprising the above-mentioned collision reaction cell without charge accumulation.

[0050] The above embodiments only express several embodiments of the present application, and the description is more specific and detailed, but it cannot be understood as a limitation on the scope of the patent. It should be noted that for ordinary skilled persons in the art, without departing from the concept of the present application, a number of modifications and improvements can be made, which are equivalent modifications and evolutions of the above embodiments according to the essential technology of the present application, and these all belong to the protection scope of the present application.

Claims

1. A collision reaction cell without charge accumulation, comprising a collision cell body and two transition ends, the two transition ends are respectively installed at both ends of the collision cell body, the collision cell body comprises an insulating cylinder and a main quadrupole rod installed on the insulating cylinder, characterized in that: The insulating cylinder comprises a cylinder body and a conductive ring at the end of the cylinder body, the inner side of the cylinder body is provided with a conductive plating layer, the conductive plating layer extends to the conductive ring, the transition end comprises a conductive end cover and a conductive sealing ring, the conductive end cover is connected with the insulating cylinder, the conductive sealing ring is located between the conductive end cover and the conductive ring, the electric charge inside the insulating cylinder is guided to the conductive end cover through the conductive plating layer, the conductive ring and the conductive sealing ring, the conductive end cover can be grounded to guide the electric charge out, the conductive sealing ring forms a seal between the conductive end cover and the insulating cylinder, the transition end further comprises a support and a pre-quadrupole rod, the pre-quadrupole rod is installed on the support, the support is made of insulating material, the support is provided with a hollow groove, the hollow groove reduces the adhesion of the escaped ions to the support.

2. The charge-accumulation-free collisional reaction cell of claim 1, wherein: The transition end further comprises a first connecting column, the support is provided with a first mounting hole, the first connecting column is installed in the first mounting hole and connected with the pre-quadrupole rod, so that the pre-quadrupole rod is installed on the support.

3. The charge accumulation free collisional reaction cell of claim 1, wherein: The support is installed on the conductive end cover.

4. The charge accumulation free collisional reaction cell of claim 3, wherein: The conductive end cover is provided with a mounting groove, the transition end further comprises an anti-rotation block, the anti-rotation block is fixed on the support, the anti-rotation block is located in the mounting groove, and the anti-rotation block prevents the support from rotating circumferentially relative to the conductive end cover.

5. The charge accumulation free collisional reaction cell of claim 3, wherein: The conductive end cover is provided with a positioning groove, the support is provided with a fixing hole, the transition end further comprises a cylindrical pin, the cylindrical pin is located in the positioning groove and extends into the fixing hole, and the cylindrical pin prevents the support from moving axially relative to the conductive end cover.

6. The charge accumulation free collisional reaction cell of claim 5, wherein: The positioning groove is L-shaped.

7. The charge accumulation free collisional reaction cell of claim 1, wherein: The transition end further comprises a lens pole piece, the lens pole piece comprises a terminal, the lens pole piece is installed between the support and the conductive end cover, and the terminal extends from the conductive end cover.

8. The charge accumulation free collisional reaction cell of claim 1, wherein: The conductive end cover is provided with a threaded hole, the cylinder body is provided with a conical hole, a fastener extends into the threaded hole and the conical hole, and the cylinder body and the conductive end cover are fixed.

9. A mass spectrometer, characterized by: The collision reaction cell without charge accumulation comprises the transition end as claimed in any one of claims 1-8. The collision reaction cell without charge accumulation comprises the transition end as claimed in any one of claims 1-8.

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