Medical systems and storage media

Abstract

The present application discloses a medical system and a storage medium, the medical system includes: a memory and a processor, the memory is used to store a computer program; the processor is used to execute the computer program and implement the following anticoagulation control method: when the user's operation indicating blood purification is detected, the blood circuit is controlled to transmit blood for blood purification; the actual flow rate of the blood in the blood circuit is detected, when the actual flow rate meets the first condition, the second flow rate of the anticoagulation branch is determined according to the actual flow rate, and a first control instruction is issued to the infusion pump, the first condition is: the difference between the actual flow rate and the first flow rate is greater than the preset error value; when the infusion pump receives the first control instruction, the infusion pump controls the anticoagulation branch according to the first control instruction to output the anticoagulant to the blood circuit at the second flow rate. The present application can automatically match the blood purification equipment and the infusion pump for linkage control to ensure the safety of the patient during the blood purification process.

Description

Technical Field

[0001] The present application relates to the technical field of blood purification, and in particular to a medical system and a storage medium. Background Art

[0002] During the blood purification treatment process, an infusion pump is needed to perform infusion to ensure the normal operation of the blood purification equipment; for example, when the patient's blood is drawn into the extracorporeal tubing, the contact between the blood and the inner wall of the tubing can trigger the body's coagulation mechanism. The blood is prone to coagulation in the extracorporeal tubing, which can cause thrombosis and endanger the patient's blood purification safety.

[0003] In order to solve the coagulation failure during blood purification treatment, the traditional technology will control the automatic output of anticoagulants through the infusion pump, and use the anticoagulant to exert the blood anticoagulation effect in the extracorporeal pipeline to ensure the anticoagulation safety during blood purification treatment. However, in the traditional technology, the blood purification equipment and the infusion pump cannot be linked and controlled, and the infusion pump parameter configuration accuracy is not high, which reduces the anticoagulation safety of the patient's blood purification control process and has a large random error. Summary of the invention

[0004] Based on this, the present application provides a medical system and storage medium that can automatically match and control the blood purification equipment and the infusion pump to ensure the safety of patients during the blood purification process.

[0005] In a first aspect, the present application provides a medical system, which includes: an infusion pump and a blood purification device; the infusion pump is communicatively connected to the blood purification device, the blood purification device includes: an anticoagulation branch, a blood circuit and a blood purifier, the blood circuit is used to transmit blood, the anticoagulation branch is connected to the blood circuit, the blood purifier is serially connected in the blood circuit, and the blood purifier is used to purify blood; the infusion pump is arranged on the anticoagulation branch, and the infusion pump is used to control the flow state of the anticoagulant in the anticoagulation branch; the medical system also includes: a memory and a processor, the memory is used to store a computer program; the processor is used to execute the computer program and when executing the computer program, implement the following anticoagulation control method for the medical system:

[0006] When a user's operation indicating blood purification is detected, controlling the blood circuit to transfer blood to purify the blood;

[0007] Detecting the actual flow rate of blood in the blood circuit, and when the actual flow rate meets a first condition, determining a second flow rate of the anticoagulation branch according to the actual flow rate, and controlling the blood purification device to issue a first control instruction to the infusion pump, wherein the first condition is that a difference between the actual flow rate and the first flow rate is greater than a preset error value, and the first flow rate is a preset blood flow rate of the blood circuit in a normal blood purification process under a currently selected blood purification treatment mode;

[0008] When the infusion pump receives the first control instruction, the infusion pump controls the anticoagulation branch to output the anticoagulant to the blood circuit at the second flow rate according to the first control instruction.

[0009] In a second aspect, the present application provides a computer-readable storage medium storing a computer program, which, when executed by a processor, enables the processor to implement the anticoagulation control method for the medical system as described above.

[0010] The embodiment of the present application provides a medical system and a storage medium, wherein communication can be achieved between an infusion pump and a blood purification device. When the blood purification device performs blood purification in the currently selected blood purification treatment mode according to the user's instructions, the difference between the actual flow rate of blood in the blood circuit and the first flow rate during normal blood purification is greater than a preset error value, the second flow rate of the anticoagulation branch is determined according to the actual flow rate, and a first control instruction is issued to the infusion pump, so that the infusion pump controls the anticoagulation branch to output the anticoagulant to the blood circuit at the second flow rate; since communication linkage control can be achieved between the infusion pump and the blood purification device, the infusion pump automatically sets the output rate of the anticoagulant according to the actual flow rate of blood in the blood circuit, so that the blood flow rate and the anticoagulant flow rate can be automatically and safely matched and controlled, which can ensure the safety of patients during the blood purification process and reduce the anticoagulation safety risk during the blood purification treatment process; the entire process does not require manual settings, which can simplify the anticoagulation control steps in the blood purification process, and bring great convenience to the clinical operations of medical staff.

[0011] It should be understood that the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the present application. BRIEF DESCRIPTION OF THE DRAWINGS

[0012] Figure 1 It is a schematic diagram of the overall structure of an embodiment of a blood purification device CRRT machine in the medical system of the present application;

[0013] Figure 2 It is a schematic diagram of the overall structure of an embodiment of an infusion pump in the medical system of the present application;

[0014] Figure 3 It is a flow chart of an embodiment of an anticoagulation control method of the medical system of the present application;

[0015] Figure 4 It is a schematic diagram of the principle of an embodiment of the medical system of the present application;

[0016] Figure 5 It is a schematic diagram of the specific principle of the citrate anticoagulation method in the medical system of the present application;

[0017] Figure 6 It is a schematic diagram of a fitting curve of a second flow rate and a third flow rate in an embodiment of an anticoagulation control method of a medical system of the present application;

[0018] Figure 7 It is a structural diagram of an embodiment of the medical system of the present application. DETAILED DESCRIPTION

[0019] The following will be combined with the drawings in the embodiments of the present application to clearly and completely describe the technical solutions in the embodiments of the present application. Obviously, the described embodiments are part of the embodiments of the present application, not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of this application.

[0020] The flowcharts shown in the accompanying drawings are only examples and do not necessarily include all the contents and operations / steps, nor must they be executed in the order described. For example, some operations / steps may also be decomposed, combined or partially merged, so the actual execution order may change according to actual conditions.

[0021] Before describing the embodiments of the present application in detail, the relevant technical contents are first introduced.

[0022] Blood purification is to draw the patient's blood out of the body and pass it through a purification device to remove certain pathogenic substances in it, so as to purify the blood and treat the disease. After years of clinical treatment, it has been proved that blood purification has played a key role in the rescue and treatment of various critically ill patients, and is one of the important organ support methods. Taking the continuous renal replacement therapy (CRRT, Continuous Renal Replacement Therapy) machine in the blood purification equipment as an example, technicians usually use CRRT machines to achieve blood purification functions. The main purpose of CRRT machines is to remove excess water, metabolic waste, and toxins in the body, correct water and electrolyte disorders, ensure nutritional support, promote renal function recovery, and remove various cytokines and inflammatory mediators; CRRT machines have been widely used in various acute and chronic renal failure with unstable cardiovascular function, high catabolism, or accompanied by cerebral edema, as well as multiple organ dysfunction syndrome, acute respiratory distress syndrome, crush syndrome, acute necrotizing pancreatitis, chronic heart failure, hepatic encephalopathy, drug and toxic poisoning, etc.; Among them Figure 1 The overall structure of the CRRT machine is shown.

[0023] Infusion pumps are a commonly used medical device that can realize automatic infusion control functions. For example, by manually configuring various parameters of the infusion pump, such as infusion volume, infusion time, infusion rate, etc., the infusion pump can infuse according to the pre-configured parameters, and there is no need to manually control the infusion process, which greatly facilitates the infusion control process of medical staff. Figure 2 The overall structure of the infusion pump is shown.

[0024] When using a CRRT machine for blood purification treatment, an infusion pump is also required to infuse fluids to ensure the normal operation of the CRRT machine; for example, when the patient's blood is drawn into the extracorporeal circuit, the contact between the blood and the inner wall of the circuit can trigger the body's coagulation mechanism, and blood is prone to coagulation in the extracorporeal circuit, which can cause thrombosis and endanger the patient's blood purification safety. In order to solve the coagulation failure during blood purification treatment, traditional technology will control the automatic output of anticoagulants through an infusion pump, and use the anticoagulant to exert the blood anticoagulation effect in the extracorporeal circuit to ensure the anticoagulation safety during blood purification treatment. However, in the current clinical application process, the CRRT machine and the infusion pump are two isolated and independent electronic components, and the two cannot communicate with each other. If a CRRT machine is used for blood purification, the user can only control the infusion pump alone to start the infusion pump and output the anticoagulant, and there is no linkage control between the CRRT machine and the infusion pump. This not only brings great inconvenience to the operation and control process of medical staff, but also the anticoagulation control process of the blood purification equipment is very complicated. In addition, medical staff also need to manually control the start and stop of the infusion pump, as well as the configuration of the infusion pump parameters, which leads to low control accuracy. If errors occur during the manual control of the infusion pump (for example, unreasonable configuration of the infusion pump parameters, etc.), this will seriously affect the anticoagulation safety of the patient's blood purification control process and has a large random error.

[0025] The embodiment of the present application provides a medical system and a storage medium, wherein communication can be achieved between an infusion pump and a blood purification device. When the blood purification device performs blood purification in the currently selected blood purification treatment mode according to the user's instructions, the difference between the actual flow rate of blood in the blood circuit and the first flow rate during normal blood purification is greater than a preset error value, the second flow rate of the anticoagulation branch is determined according to the actual flow rate, and a first control instruction is issued to the infusion pump, so that the infusion pump controls the anticoagulation branch to output the anticoagulant to the blood circuit at the second flow rate; since communication linkage control can be achieved between the infusion pump and the blood purification device, the infusion pump automatically sets the output rate of the anticoagulant according to the actual flow rate of blood in the blood circuit, so that the blood flow rate and the anticoagulant flow rate can be automatically and safely matched and controlled, which can ensure the safety of patients during the blood purification process and reduce the anticoagulation safety risk during the blood purification treatment process; the entire process does not require manual settings, which can simplify the anticoagulation control steps in the blood purification process, and bring great convenience to the clinical operations of medical staff.

[0026] For example, Figure 1 and Figure 2The overall structure schematics shown separately show that the CRRT machine is used to realize the blood purification function, and the infusion pump is used for the anticoagulant output control function; when the patient's blood is purified by the CRRT machine, the anticoagulant is output to the extracorporeal circuit through the infusion pump to realize the blood anticoagulation function; then on the CRRT machine, the user only needs to operate on the display screen of the CRRT machine to synchronously control the operating status of both the CRRT machine and the infusion pump, which brings great convenience to the user's operation.

[0027] See also Figure 3 , Figure 3 It is a flow chart of an embodiment of the anticoagulation control method of the medical system of the present application. It should be noted that the method of the embodiment of the present application is executed by a medical system. The medical system in the embodiment of the present application includes: an infusion pump and a blood purification device; the infusion pump is communicatively connected to the blood purification device, for example, the infusion pump and the blood purification device can be connected via Bluetooth, and the infusion pump and the blood purification device can realize two-way data transmission. Normally, most of the steps in the method of the embodiment of the present application can be executed by the blood purification device, and the remaining other steps can be executed by the infusion pump; how to execute the relevant steps by the blood purification device and the infusion pump can be determined according to the actual situation and is not limited here.

[0028] For details, please refer to Figure 4 , Figure 4 A schematic diagram of the principle of a medical system is shown, wherein the blood purification equipment comprises: an anticoagulation branch, a blood circuit and a blood purifier, wherein the blood circuit is used to transmit blood; wherein the blood circuit comprises: an arterial line and a venous line, wherein the anticoagulation branch is connected to the blood circuit, wherein the blood purifier is connected in series in the blood circuit, and wherein the blood purifier is used to purify blood; wherein the infusion pump is arranged on the anticoagulation branch, wherein the infusion pump is used to control the flow state of the anticoagulant in the anticoagulation branch; wherein the medical system further comprises: a liquid storage bag, wherein the liquid storage bag is used to store the anticoagulant, wherein the first end of the anticoagulation branch is connected to the liquid storage bag, and the second end of the anticoagulation branch is connected to the blood circuit, wherein when blood exists in the blood circuit, the flow state of the anticoagulant in the anticoagulation branch is controlled by the infusion pump, such as controlling the output rate of the anticoagulant in the anticoagulation branch by the infusion pump, and the anticoagulation branch outputs the anticoagulant to the blood circuit to prevent blood coagulation failure in the blood circuit, thereby realizing the anticoagulation control function.

[0029] The anticoagulation control method of the medical system includes: step S101, step S102 and step S103.

[0030] Step S101: when a user's operation indicating blood purification is detected, the blood circuit is controlled to transfer blood to purify the blood.

[0031] Before starting blood purification, it is necessary to select a blood purification treatment mode of the blood purification device according to the patient's clinical treatment symptoms.

[0032] Specifically, blood purification equipment can realize a variety of blood purification treatment modes, such as hemodialysis treatment mode, hemoperfusion treatment mode, etc., and each blood purification treatment mode can be applied to specific clinical treatment symptoms. For example, the hemodialysis treatment mode can be applied to clinical treatment symptoms such as renal failure and blood poisoning where the body cannot excrete toxic substances on its own; for example, the hemoperfusion treatment mode can be applied to clinical treatment symptoms such as rescue drugs and poison poisoning, infectious diseases, uremia, etc. Therefore, the blood purification treatment mode of the blood purification equipment is selected according to the patient's clinical treatment symptoms to achieve the best blood purification treatment effect for the patient.

[0033] Then, the first flow rate of the blood circuit is set according to the selected blood purification treatment mode.

[0034] Among them, the first flow rate can represent: the blood flow rate of the blood circuit during the normal blood purification process in the selected blood purification treatment mode. After the blood purification equipment is started, there will be a series of stages; for example, the blood purification equipment will go through: pre-flushing, blood extraction, blood purification process, and blood return in sequence; only when the blood purification equipment is in the blood purification process, it is necessary to output the anticoagulant into the blood circuit to achieve the effect of blood anticoagulation; when the blood purification is in other stages, no anticoagulation operation is required.

[0035] The first flow rate of the blood circuit is set according to the selected blood purification treatment mode, which can be specifically: presetting the corresponding relationship between each blood purification treatment mode and the flow rate of the blood circuit; finding the corresponding flow rate of the blood circuit in the corresponding relationship according to the selected blood purification treatment mode, and using the corresponding flow rate of the blood circuit as the first flow rate of the blood circuit. It should be noted that the "flow rate of the blood circuit" refers to the flow rate of the blood circuit during normal blood purification.

[0036] Among them, after selecting the blood purification treatment mode of the blood purification device, the first flow rate corresponding to the selected blood purification treatment mode will be obtained; for example, in the blood perfusion treatment mode, the flow rate of the blood circuit in the normal blood purification process is 100ml / min; for example, in the hemodialysis treatment mode, the flow rate of the blood circuit in the normal blood purification process is 120ml / min. According to the user's clinical operation experience, the correspondence between each blood purification treatment mode and the flow rate of the blood circuit in the normal blood purification process can be pre-set, and the correspondence can be presented in a table, as shown in Table 1 below:

[0037] Table 1

[0038]

[0039]

[0040] It should be noted that the data in Table 1 above are only used for examples and do not mean that the data in Table 1 above will be used in actual clinical applications; therefore, after the blood purification treatment mode of the blood purification device is selected, the corresponding blood circuit flow rate in the normal blood purification process, that is, the first flow rate, can be found according to the selected blood purification treatment mode according to the corresponding relationship in Table 1 above; the embodiment of the present application can obtain the first flow rate of the blood circuit according to the corresponding relationship pre-set in Table 1.

[0041] If the first flow rate of the blood circuit during normal blood purification in the currently selected blood purification treatment mode has been set in advance, setting the first flow rate of the blood circuit according to the selected blood purification treatment mode may be omitted.

[0042] The user's blood purification instruction operation represents: the user's start-up control demand for the blood purification device. When the user's blood purification instruction operation is detected, the blood purification device receives the blood purification instruction and controls the display screen of the blood purification device according to the blood purification instruction to formally start the blood purification device and start the blood purification process. For example, please refer to Figure 4 When the display screen of the blood purification device receives a blood purification instruction, the blood pump is controlled to operate according to the blood purification instruction. The operation of the blood pump provides driving force, and the blood is transmitted in the blood circuit. When the blood passes through the blood purifier, the blood is purified by the blood purifier to achieve the blood purification function.

[0043] Step S102: Detect the actual flow rate of blood in the blood circuit. When the actual flow rate meets a first condition, determine the second flow rate of the anticoagulation branch according to the actual flow rate, and control the blood purification equipment to issue a first control instruction to the infusion pump. The first condition is that the difference between the actual flow rate and the first flow rate is greater than a preset error value. The first flow rate is a pre-set blood flow rate of the blood circuit during normal blood purification in the currently selected blood purification treatment mode.

[0044] In the above first condition, the preset error value is a value set in advance.

[0045] Specifically, when the blood circuit is transmitting blood, the actual flow rate of the blood in the blood circuit can be detected by a flow rate detector (such as an ultrasonic detector). When the blood purification device is started, the actual flow rate of the blood in the blood circuit will change; for example, when the blood purification device is in the pre-flushing stage, the blood introduction stage and the blood return stage, the blood purification device will not purify the blood. For example, in the pre-flushing stage, the blood circuit is only flushed with the pre-flushing liquid; for example, in the blood introduction stage, the human body's blood is drawn into the blood circuit; for example, in the blood return stage, the residual blood in the blood circuit is returned to the human body; in these three stages, the liquid flow rate in the blood circuit of the blood purification device will be relatively low, which will be lower than: the blood flow rate (that is, the first flow rate) in the normal blood purification process; therefore, by judging whether the actual flow rate meets the first condition, it can be judged whether the blood purification device is in the normal blood purification process; only when the actual flow rate meets the first condition, it is judged that the blood purification device is in the normal blood purification process, and the second flow rate of the anticoagulation branch is determined according to the actual flow rate, and the blood purification device sends a first control instruction to the infusion pump, and the first control instruction is used to instruct the infusion pump to control the anticoagulation branch to output the anticoagulant to the blood circuit according to the second flow rate. When the actual flow rate does not meet the first condition, it is determined that the blood purification device is in the pre-flushing stage, the blood extraction stage, or the blood return stage. If the anticoagulation operation is not required in these three stages, the infusion pump does not need to be started, and the blood purification device will not send the first control instruction to the infusion pump. Therefore, the embodiment of the present application determines whether the blood purification device needs an anticoagulation operation based on the difference between the actual flow rate and the first flow rate, thereby achieving complete synchronization between the normal blood purification process of the blood purification device and the anticoagulation operation of the infusion pump.

[0046] Exemplarily, if the actual flow rate of blood in the blood circuit is detected to be 90ml / min, the blood perfusion treatment mode is selected according to the patient's clinical treatment symptoms. According to Table 1 above, the first flow rate is 100ml / min; wherein the preset error value represents the allowable fluctuation value of the blood flow rate in the blood circuit during normal blood purification. For example, the preset error value is -5ml / min, then in the above: 90ml / min-100ml / min=-10ml / min, wherein -10ml / min<-5ml / min, the above first condition is not met, then it is judged that: the blood purification equipment is not in a normal blood purification process, and the blood purification equipment will not send the first control instruction to the infusion pump.

[0047] Step S103: When the infusion pump receives the first control instruction, the infusion pump controls the anticoagulation branch to output the anticoagulant to the blood circuit at the second flow rate according to the first control instruction.

[0048] Specifically, when the infusion pump receives the first control instruction, the infusion pump starts the anticoagulation operation. Through the operation of the infusion pump, a driving force is provided to the anticoagulation branch. The anticoagulation branch outputs the anticoagulant into the blood circuit. The anticoagulant plays an anticoagulant role in the blood circuit, thereby ensuring that the blood in the blood circuit can maintain normal and safe flow during the normal blood purification process.

[0049] The second flow rate of the anticoagulation branch is determined according to the actual flow rate of the blood in the blood circuit, which can be performed according to the following formula:

[0050] The second flow rate of the anticoagulation branch = proportionality coefficient * actual flow rate (1)

[0051] In the above formula (1), the proportionality coefficient is a pre-set parameter (wherein, this proportionality coefficient is a fixed value that can be obtained by summarizing multiple experiments); for example, the proportionality coefficient is: 1 / 50. If the actual flow rate of blood in the blood circuit is detected to be: 100ml / min, according to the above formula (1), it is calculated that: the second flow rate is 120ml / h, then the infusion pump controls the anticoagulation branch to output the anticoagulant to the blood circuit at 120ml / h, so as to achieve that the flow rate of blood in the blood circuit and the flow rate of anticoagulant in the anticoagulation branch are matched, so that the flow rate of the anticoagulant will not be too fast or too slow, thereby ensuring the safety of the patient's blood purification treatment.

[0052] It should be noted that the above formula (1) is only one specific calculation method for the second flow rate. In the actual process, many other specific calculation formulas can be derived (as long as these specific calculation formulas are reasonable). Other specific calculation formulas will not be discussed in detail.

[0053] In an embodiment of the present application, the anticoagulation output rate of the anticoagulation branch can be calculated without the need for manual control and manual setting, which greatly reduces the anticoagulation control error in the blood purification process and reduces the complexity of manual operation; and the embodiment of the present application automatically determines whether it is necessary to start the infusion pump for anticoagulation operation based on the actual flow rate of blood in the blood circuit. The blood flow rate of the blood purification equipment during the blood purification process is completely matched with the anticoagulant output rate, and there is no need for manual judgment on when the blood circuit needs anticoagulation operation; the embodiment of the present application realizes the automatic anticoagulation control function of the blood purification equipment, and the blood purification equipment and the infusion pump can be jointly controlled, which simplifies the anticoagulation control steps of the blood in the blood circuit and improves the safety of the patient's blood purification treatment.

[0054] As an optional embodiment, the anticoagulant is heparin or citrate solution; when the anticoagulant is heparin, when the blood purification device is in the blood purification process, the anticoagulant branch outputs heparin into the blood circuit, and heparin has an anticoagulant effect in the blood circuit; the anticoagulant principle of heparin is as follows: in addition to binding with antithrombin III to enhance its activity, heparin can also bind to platelets, inhibiting platelet aggregation and the release of platelet factors, thereby achieving an anticoagulant effect on the blood, and the anticoagulant branch is controlled by the infusion pump to output heparin to the blood circuit at a second flow rate to meet the anticoagulant requirements during the blood purification process.

[0055] Optionally, when the anticoagulant is citric acid solution, when the blood purification equipment is in the blood purification process, the anticoagulation branch outputs the citric acid solution into the blood circuit, and the citric acid solution has an anticoagulant effect in the blood circuit; the anticoagulation principle of citric acid solution is: the blood coagulation process in the blood circuit requires the participation of free calcium, and there are citrate ions in the citric acid solution. The citrate ions and the calcium ions in the blood generate a difficult-to-dissociate soluble complex, calcium citrate. This complex is easily soluble in water and difficult to dissociate, and the coagulation process is inhibited, thereby preventing blood coagulation; the citric acid anticoagulation method will cause a large loss of calcium ions. If the calcium ions cannot be supplemented in time, the patient will develop hypocalcemia; therefore, in the citric acid anticoagulation method, it is also necessary to supplement an appropriate amount of calcium to ensure the normal progress of the anticoagulation process.

[0056] See also Figure 5 , Figure 5The specific principle of the citric acid anticoagulation method is shown. The blood circuit includes: an arterial line and a venous line. The blood purifier is connected between the arterial line and the venous line. The arterial line is used to output blood to the blood purifier, and the venous line is used to output the purified blood to the patient's vein; the infusion pump includes: a citric acid pump and a calcium pump. The anticoagulant includes: citric acid solution and calcium solution. The anticoagulation branch includes: a first output branch and a second output branch. The first output branch is connected to the arterial line, and the second output branch is connected to the venous line; the citric acid pump is arranged on the first output branch, and the citric acid pump is used to control the flow state of the citric acid solution in the first output branch; the calcium pump is arranged on the second output branch, and the calcium pump is used to control the flow state of the calcium solution in the second output branch. Among them, the first end of the first output branch is connected to the first liquid storage bag, the second end of the first output branch is connected to the arterial line, the first liquid storage bag is used to store citrate solution, and the first output branch outputs the citrate solution to the arterial line, thereby playing a blood anticoagulation effect in the blood circuit; the first end of the second output branch is connected to the second liquid storage bag, the second end of the second output branch is connected to the venous line, the second liquid storage bag is used to store calcium solution, and the second output branch outputs the calcium solution to the venous line to make up for the calcium ions lost during the anticoagulation process of the citrate solution; therefore, the embodiment of the present application combined with the citrate pump and the calcium pump can ensure the normal anticoagulation function of the blood in the blood circuit.

[0057] At this time, step S103, when the infusion pump receives the first control instruction, the infusion pump controls the anticoagulation branch according to the first control instruction to output the anticoagulant to the blood circuit at the second flow rate, which may include: sub-step S1031 and sub-step S1032.

[0058] Sub-step S1031: When the citrate pump receives the first control instruction, the citrate pump controls the first output branch to output the citrate solution to the arterial line at the second flow rate according to the first control instruction, and controls the citrate pump to send a second control instruction to the calcium pump.

[0059] In an embodiment of the present application, communication can be achieved between the citrate pump and the calcium pump. When the blood purification device is in the blood purification process, the blood purification device outputs a first control instruction to the citrate pump, and the citrate pump starts the citrate anticoagulation process according to the first control instruction, and the second flow rate and the actual flow rate of the blood in the blood circuit match each other to ensure the normal flow function of the blood in the blood circuit; and when the citrate pump is started and the first output branch outputs the citrate solution to the arterial line, the citrate pump outputs the second control instruction to the calcium pump, so that the calcium pump controls the second output branch to output the calcium solution to the venous line, to ensure the normal anticoagulation effect of the blood in the blood circuit.

[0060] Sub-step S1032: when the calcium pump receives a second control instruction, the calcium pump controls the second output branch to output the calcium solution to the venous line at a third flow rate according to the second control instruction, wherein the third flow rate is obtained according to the second flow rate.

[0061] The second control instruction is used to instruct the calcium pump to control the second output branch to output the calcium solution to the venous line at a third flow rate. The third flow rate is obtained based on the second flow rate. Among them, the third flow rate can be obtained based on the second flow rate and a preset control relationship. The preset control relationship can be obtained based on previous clinical technical experience or can also be obtained based on multiple clinical experiments. There is a completely matching relationship between the third flow rate and the second flow rate. When the calcium pump controls the second output branch to output the calcium solution to the venous line at the third flow rate, the calcium ions connected to the venous line can just make up for the calcium ion loss caused by citrate anticoagulation. When the blood is returned to the human vein through the venous line, the blood output from the venous line can reach the normal blood parameter level of the human body.

[0062] Exemplarily, the preset comparison relationship can be obtained by Figure 6 The fitting curve in is represented by Figure 6 The fitting curve in the figure shows that there is a one-to-one correspondence between the second flow rate and the third flow rate. After the second flow rate of the first output branch is obtained, the second flow rate can be calculated according to Figure 6 The third flow rate can be obtained by fitting the curve in the figure, which is easy to operate. For example, if the second flow rate is 150 ml / h, the third flow rate can be obtained by fitting the curve as: 175 ml / h.

[0063] Therefore, according to the preset control relationship, the embodiment of the present application can make the output rate of the citrate solution and the output rate of the calcium solution completely match each other, thereby avoiding the following adverse reactions that may exist in the citrate anticoagulation method: if the output rate of the calcium solution in the second output branch is too high, it will cause excessive calcium supplementation in the venous line, which will cause hypercalcemia in the patient; if the output rate of the calcium solution in the second output branch is too low, it will cause too little calcium supplementation in the venous line, which will cause hypocalcemia in the patient; the citrate anticoagulation method in the embodiment of the present application has higher safety and stability.

[0064] In one embodiment, the method further includes: step S104 and step S105.

[0065] Step S104: respectively detecting a first temperature of the citric acid solution in the first output branch, a second temperature of the calcium solution in the second output branch, and a safe temperature of the blood in the venous line.

[0066] Step S105: When the first temperature, the second temperature and the safety temperature do not meet the second condition, an alarm signal is issued, and the second condition is: the absolute value of the difference between the first temperature and the second temperature is less than the first preset temperature difference, the absolute value of the difference between the safety temperature and the first temperature is less than the second preset temperature difference, and the absolute value of the difference between the safety temperature and the second temperature is less than the third preset temperature difference.

[0067] Converted into mathematical expression, the second condition is:

[0068] |First temperature-second temperature|<first preset temperature difference, |safety temperature-first temperature|<second preset temperature difference, |safety temperature-second temperature|<third preset temperature difference; wherein, the first preset temperature difference, the second preset temperature difference and the third preset temperature difference are all pre-set values.

[0069] like Figure 5As shown, when the blood purification device selects the citrate anticoagulation mode, when the citrate solution is output to the arterial line through the citrate pump, the citrate solution is pre-stored in the first liquid storage bag. Since the first liquid storage bag is outside for a long time, the liquid stored in the first liquid storage bag will have an abnormal temperature drop; since in the blood purification process, the blood after blood purification needs to be returned to the patient's body, the citrate solution and calcium solution in the embodiment of the present application are "external liquids" relative to the blood in the blood circuit. If the citrate solution and calcium solution are introduced into the blood circuit, the temperature of the blood in the blood circuit drops rapidly, and the blood circuit returns the cooled blood to the patient's body. This low-temperature blood will cause great stimulation to the patient and increase the patient's pain. In order to prevent the patient from experiencing discomfort symptoms caused by this abnormal temperature drop, the embodiment of the present application detects the first temperature of the citrate solution, the second temperature of the calcium solution and the safe temperature of the blood in the venous line, and judges according to the second condition whether the anticoagulation process of the blood circuit has low temperature symptoms.

[0070] Among them, |first temperature-second temperature| represents: the absolute value of the difference between the first temperature and the second temperature, which is used to evaluate whether the difference between the first temperature of the citrate solution and the second temperature of the calcium solution is too large. Once the difference between the first temperature and the second temperature is too large, it will cause a large difference between the temperature of the blood in the arterial line and the temperature of the blood in the venous line. The temperature of the blood returned to the patient's body will fluctuate greatly, causing discomfort to the patient; |safety temperature-first temperature| represents: the absolute value of the difference between the safety temperature and the first temperature, which is used to evaluate whether the first temperature of the citrate solution is too large. Whether the difference between the first temperature of the citrate solution and the safe temperature of the blood in the venous line is too large; |safety temperature - second temperature| represents: the absolute value of the difference between the safety temperature and the second temperature, which is used to evaluate whether the difference between the second temperature of the calcium solution and the safe temperature of the blood in the venous line is too large; once the difference between the first temperature of the citrate solution and the safe temperature of the blood in the venous line is too large, or the difference between the second temperature of the calcium solution and the safe temperature of the blood in the venous line is too large, this will cause the temperature of the blood returned to the patient's body from the blood circuit to be abnormal, causing the patient to experience discomfort during the blood purification process.

[0071] When it is detected that the first temperature, the second temperature and the safety temperature meet the second condition, it means that the temperature of the liquid in each branch of the blood purification device is in a normal state, and there is no need to issue an alarm signal (such as an audible and visual alarm signal); when it is detected that the first temperature, the second temperature and the safety temperature do not meet the second condition, it means that the temperature of the liquid in at least one branch of the blood purification device is in a fault state, and an alarm signal is issued. Once the user receives the alarm signal, he can immediately deal with: the temperature failure of the liquid in the branch of the blood purification device. Therefore, the embodiment of the present application detects the temperature of various liquids in the pipeline, and comprehensively judges from all angles whether the temperature of the liquid in each branch of the blood purification device is in a fault state, thereby preventing the patient from experiencing discomfort symptoms due to the temperature failure of the liquid in the branch.

[0072] It should be noted that by detecting the safe temperature of the blood in the venous line and taking the safe temperature as a reference value, by comparing the difference between the first temperature of the citrate solution and the safe temperature of the blood in the venous line, and by comparing the difference between the second temperature of the calcium solution and the safe temperature of the blood in the venous line, it is possible to determine whether the temperature of the anticoagulant is faulty; once the temperature of the anticoagulant is faulty, this will directly lead to a temperature fault in the blood circuit. Among them, the embodiment of the present application takes the "safe temperature of the blood in the venous line" as a reference value, but does not take the "temperature of the blood in the arterial line" as a reference value. The reason for this can be seen in Figure 5 The blood in the arterial line is "blood that is drawn from the human body's arteries and has not been purified"; the blood in the venous line is "purified blood that needs to be returned to the human body's veins"; therefore, by detecting the temperature of the blood in the venous line, it is possible to more accurately determine whether the temperature of the blood returned to the human body's veins is in a faulty state.

[0073] Exemplarily, if the first temperature of the citric acid solution in the first output branch is detected to be 30°C, the second temperature of the calcium solution in the second output branch is detected to be 31°C, and the safety temperature of the blood in the venous line is detected to be 36°C, according to clinical technical experience, the first preset temperature difference is 3°C, the second preset temperature difference is 7°C, and the third preset temperature difference is 7°C; therefore: | first temperature - second temperature | = 1°C, 1°C < 3°C, | safety temperature - first temperature | = 6°C, 6°C < 7°C, | safety temperature - second temperature | = 5°C, 5°C < 7°C, if the second condition is met, it means that the temperature of the liquid in each branch of the blood purification device is in a normal state, and there is no need to send an alarm signal. Therefore, the embodiment of the present application can conveniently monitor whether the temperature of the liquid in each branch of the blood purification device is faulty.

[0074] In one embodiment, the method further includes: step S106 and step S107.

[0075] Step S106: Detecting the pH value of the blood in the venous line.

[0076] Step S107: When the pH value of the blood is greater than a preset pH value, it is determined that metabolic alkalosis occurs in the blood in the venous line.

[0077] Due to the use of citric acid anticoagulation, citric acid solution contains sodium citrate, and each 1mmol of sodium citrate contains 3mmol of sodium ions and COO- ions. A large amount of input into the body can lead to hypernatremia and metabolic alkalosis. Specifically, when the citric acid pump continuously outputs citric acid solution into the blood circuit, HCO3 in human blood will accumulate, causing the blood of the human body to be alkaline. The pH value of the blood in the blood circuit is greater than 7. When HCO3 accumulates continuously and exceeds the warning value, the patient will have metabolic alkalosis during the blood purification process. Its clinical symptoms are as follows: the patient's breathing becomes shallower and slower, the excitability of the nerve muscles increases, and even consciousness disorders occur. The embodiment of the present application detects the pH value of the blood in the venous line to determine whether the citric acid anticoagulation method causes metabolic alkalosis in the patient, and identifies whether the patient has metabolic alkalosis by quantitative detection and quantitative judgment, which is accurate and simple.

[0078] Exemplarily, based on clinical technical experience, the preset pH value is: 7.45; if the pH value of the blood in the venous line is detected to be 7.55, then 7.55>7.45, and it can be determined that metabolic alkalosis occurs in the blood in the venous line.

[0079] In one embodiment, the method further includes: step S108.

[0080] Step S108: receiving a fluid replenishment instruction.

[0081] At this time, in sub-step S1031, causing the citric acid pump to control the first output branch according to the first control instruction to output the citric acid solution to the arterial line at the second flow rate may include causing the citric acid pump to control the first output branch according to the first control instruction and the fluid infusion instruction to output the mixed solution obtained by mixing the citric acid solution and the replacement fluid to the arterial line at the second flow rate.

[0082] During the blood purification process, medical staff will add replacement fluid to the arterial line according to clinical treatment needs. The replacement fluid will be returned to the human body along with the purified blood. The replacement fluid can contain substances that the human body lacks, such as bicarbonate, or drugs that can cure the patient's disease. At this time, a fluid infusion instruction will be received.

[0083] Upon receiving the fluid infusion instruction, the citrate solution may be mixed with the replacement fluid to obtain a mixed solution, and the citrate pump controls the first output branch to output the mixed solution to the arterial line at the second flow rate according to the first control instruction and the fluid infusion instruction.

[0084] If the replacement fluid does not need to be supplemented, the fluid replenishment instruction will not be received, and the citrate pump controls the first output branch to output the citrate solution to the arterial line at the second flow rate according to the first control instruction.

[0085] For details, please refer to Figure 5 In the citrate anticoagulation mode, the citrate pump controls the output of citrate solution to the arterial line; during the blood purification process, medical staff will add replacement fluid to the arterial line according to clinical treatment needs, and the replacement fluid will be returned to the human body along with the purified blood, wherein the replacement fluid may contain substances lacking in the human body such as bicarbonate, and the replacement fluid may also contain drugs that can cure the patient's disease, etc. When receiving a fluid replenishment instruction, it means that the medical staff needs to output the replacement fluid to the blood in the arterial line to achieve a better blood purification treatment effect. The embodiment of the present application mixes the citrate solution with the replacement fluid, and then outputs the mixed solution to the arterial line through the first output branch, which can achieve the dual effects of replacement fluid replenishment and blood anticoagulation, simplifying the pipeline structure design of the blood purification equipment, and making replacement fluid replenishment simple; the user does not need to redesign a branch for the replacement fluid to specifically transmit the replacement fluid.

[0086] Specifically, the citric acid solution and the replacement fluid are mixed in a specific volume ratio (such as 1:3) to obtain a mixed solution, and the first liquid storage bag stores the mixed solution in advance, and the citric acid pump controls the first output branch to output the mixed solution to the arterial line according to the first control instruction and the fluid infusion instruction, and the mixed solution is returned to the human body along with the blood in the blood circuit. The first output branch in the implementation of the present application realizes functional reuse and improves the blood purification treatment effect of the patient.

[0087] It should be noted that "replenishing replacement fluid" is not a necessary step in the blood purification process, and "whether to replenish replacement fluid" still needs to be decided by medical staff based on the patient's clinical treatment needs. For example, when some patients need to add certain drugs to their blood during the blood purification process in order to achieve the best disease treatment effect, it is necessary to mix the citrate solution and the replacement fluid in advance, and output the citrate solution and the replacement fluid to the arterial line through the first output branch; for example, when some patients do not need to add any additional drugs or nutrients during the blood purification process, it is not necessary to output the replacement fluid to the arterial line through the first output branch; therefore, when the replacement fluid needs to be replenished, the medical staff will instruct, and the medical system will receive the rehydration instruction, otherwise, the rehydration instruction will not be received.

[0088] In one embodiment, when the replacement fluid needs to be supplemented, in sub-step S1032, causing the calcium pump to control the second output branch to output the calcium solution to the venous line at a third flow rate according to the second control instruction may include: causing the calcium pump to control the second output branch to output the calcium solution to the venous line at a calibrated third flow rate according to the second control instruction, wherein the calibrated third flow rate is obtained after calibrating the third flow rate, and the calibrated third flow rate is less than the third flow rate.

[0089] When the fluid replenishment instruction is received, the third flow rate is calibrated to obtain a calibrated third flow rate, and the calcium pump controls the second output branch according to the second control instruction to output the calcium solution to the venous line at the calibrated third flow rate; wherein the calibrated third flow rate is less than the third flow rate.

[0090] Specifically, after receiving the fluid infusion instruction, the first output branch outputs the mixed citrate solution and the replacement fluid to the arterial line at the second flow rate. Under this condition, the second output branch is still controlled to output the calcium solution to the venous line at the third flow rate, which will cause too many calcium ions to accumulate in the blood in the venous line, and the patient is prone to hypercalcemia. Therefore, the embodiment of the present application distinguishes whether the fluid infusion instruction is received. If the fluid infusion instruction is received, the rate at which the second output branch outputs the calcium solution will decrease, that is, the third flow rate after calibration is less than the third flow rate before calibration, then the rate at which the second output branch outputs the calcium solution and the rate at which the first output branch outputs the citrate solution always keep matching, ensuring that the calcium ions in the patient's blood are maintained in a balanced state, and improving the anticoagulation control safety of the blood purification equipment.

[0091] The calibrating the third flow rate to obtain the calibrated third flow rate may specifically be: obtaining the calibrated third flow rate according to the mixed volume ratio between the citric acid solution and the replacement fluid and the third flow rate.

[0092] Exemplarily, when a fluid infusion instruction is received, if the mixed volume ratio between the citrate solution and the replacement fluid is: 1:3 (for example, the first liquid storage bag stores a total of 4L of mixed liquid, including 1L of citrate solution and 3L of replacement fluid); the third flow rate is 175ml / h, then the calibrated third flow rate is: 175ml / h*(1 / 4)=43.75ml / h; then the calcium pump controls the second output branch according to the second control instruction to output calcium solution to the venous line at 43.75ml / h.

[0093] Therefore, under the condition that replacement fluid needs to be supplemented, the third flow rate is calibrated to obtain the calibrated third flow rate, so that the amount of citric acid and the amount of calcium introduced into the blood circuit are always matched, maintaining the balance of calcium ion concentration in the blood circuit, and the citric acid anticoagulation method has higher safety and stability.

[0094] In one embodiment, before step S108, receiving the fluid infusion instruction, the process may further include: step S109.

[0095] Step S109: When the flow rate adjustment operation of the user is detected, the actual flow rate of the blood in the blood circuit is adjusted.

[0096] Specifically, when the blood purification device is in the process of blood purification, the blood in the blood circuit will be transmitted at a specific flow rate; if the user needs to adjust the blood flow rate in the blood circuit, such as increasing or decreasing the blood flow rate in the blood circuit, the user outputs the flow rate adjustment operation, and after detecting the user's flow rate adjustment operation, the blood flow rate in the blood circuit is controlled to be adjusted according to the user's actual needs. In an embodiment of the present application, when the actual flow rate of the blood in the blood circuit changes, the rate at which the anticoagulant is output by the anticoagulant branch will also change, and the second flow rate will change with the change in the actual flow rate of the blood in the blood circuit. The actual flow rate of the blood in the blood circuit and the rate at which the anticoagulant is output by the anticoagulant branch maintain coordinated changes. When the user adjusts the blood flow rate in the blood circuit, the infusion pump controls the anticoagulant branch to output the anticoagulant to the blood circuit, which has a good anticoagulant effect on the blood in the blood circuit, and ensures the safety and flexibility of blood flow rate regulation in the blood circuit.

[0097] In one embodiment, the method further includes: step S110.

[0098] Step S110: When the fluid infusion instruction is received, the blood circuit is set to a state where the flow rate cannot be changed; when the fluid infusion instruction is not received, the blood circuit is set to a state where the flow rate can be changed.

[0099] Specifically, when the blood circuit is in a state where the flow rate cannot be changed, the actual flow rate of the blood in the blood circuit cannot be adjusted. Even if the flow rate adjustment operation input by the user is detected, the actual flow rate of the blood in the blood circuit cannot be adjusted according to the flow rate adjustment operation. When the blood circuit is in a state where the flow rate can be changed, the actual flow rate of the blood in the blood circuit can be adjusted, and the actual flow rate of the blood in the blood circuit can be adjusted according to the flow rate adjustment operation input by the user.

[0100] In an embodiment of the present application, when a fluid infusion instruction is received, the first output branch outputs the citrate solution and the replacement fluid to the arterial line together, and the blood circuit is set to a state where the flow rate cannot be changed. This is to prevent: the blood flow rate in the blood circuit changes, causing confusion in the control process of the citrate solution output rate of the first output branch. For example, when the blood flow rate in the blood circuit changes, the mixed liquid output rate of the first output branch will change, and the citrate solution output rate of the first output branch may not be able to match the blood flow rate in the blood circuit. Therefore, in an embodiment of the present application, the actual flow rate of the blood in the blood circuit can be adjusted according to the flow rate adjustment operation only when the fluid infusion instruction is not received. In this way, it can be ensured that the actual flow rate of the blood in the blood circuit and the rate at which the citrate solution is output by the first output branch maintain coordinated changes, thereby improving the safety of regulating the blood flow rate in the blood circuit.

[0101] In one embodiment, the method further includes: step S111 and step S112.

[0102] Step S111: acquiring a first cumulative time of continuous blood transmission in the blood circuit and a second cumulative time of anticoagulant output in the anticoagulation branch.

[0103] Specifically, the first accumulated time represents: the time that the blood purification equipment continuously performs blood purification during the blood purification process; the second accumulated time represents: the time that the infusion pump continuously performs anticoagulation during the blood purification process. Based on the first accumulated time, the time for continuous blood transmission in the blood circuit can be understood; based on the second accumulated time, the time for continuous output of anticoagulant by the anticoagulation branch can be understood.

[0104] Step S112: When the difference between the first cumulative time and the second cumulative time meets the following third condition, control the blood purification device to send an alarm signal, and the third condition is: the difference between the first cumulative time and the second cumulative time is greater than the preset cumulative time.

[0105] The third condition is: first cumulative time - second cumulative time > preset cumulative time; the preset cumulative time is a preset value.

[0106] Specifically, if it is necessary to prevent the blood in the blood circuit from coagulation, once the blood purification device enters the blood purification process, the anticoagulation branch needs to output the anticoagulant to the blood circuit to play an anticoagulant role in the blood circuit; that is, once the blood circuit transmits blood, the anticoagulation branch needs to output the anticoagulant to the blood circuit, and the two are synchronized in time, that is: the difference between the first cumulative time and the second cumulative time should not be too large; based on this, according to the difference between the first cumulative time and the second cumulative time, it is possible to judge whether the blood purification process and anticoagulation are carried out synchronously; if the first cumulative time-the second cumulative time>the preset cumulative time, it means that the duration of anticoagulation is significantly shorter than the time for the blood circuit to transmit blood, then the blood purification device performs blood purification without anticoagulation, and the blood in the blood circuit is very likely to have coagulation failure, and the blood purification device sends out an audible and visual alarm signal: prompting the user to promptly deal with the anticoagulation time failure of the infusion pump, and eliminate the alarm signal of the anticoagulation time failure of the infusion pump.

[0107] It should be noted that the preset cumulative time represents the allowable error. In clinical practice, the first cumulative time will be slightly larger than the second cumulative time; however, this error will be smaller than the preset cumulative time. Once the preset cumulative time is exceeded, it means that the anticoagulation time of the anticoagulation branch is inconsistent with the time when the blood purification device is in the blood purification process. The situation of "the duration of anticoagulation is significantly shorter than the time for the blood circuit to transmit blood" may be due to a physical failure of the infusion pump, such as abnormal power failure of the infusion pump and the blood purification device is still running, or it may be due to the user's lack of experience, resulting in the abnormal manual control stop of the anticoagulation process of the infusion pump. In the actual process, many factors will cause the blood circuit to continuously transmit blood for a long time without anticoagulation.

[0108] In one embodiment, the method further includes: step S113, step S114 and step S115.

[0109] Step S113: Detecting the patient's physiological treatment parameters.

[0110] Step S114: determining whether the patient has anticoagulation complications according to the physiological treatment parameters.

[0111] Step S115: If it is determined that the patient has anticoagulation complications, the blood circuit is controlled to stop flow.

[0112] Optionally, the physiological treatment parameters include but are not limited to: the patient's heart rate, blood pressure, body temperature, etc.; by real-time monitoring of the patient's physiological treatment parameters during the blood purification process, it can be determined whether the patient has anticoagulation complications; for example, in the citrate anticoagulation method, if the calcium ions connected to the venous line are too slow, the patient will have hypocalcemia, which will cause the patient's blood pressure to drop significantly; therefore, by monitoring the patient's blood pressure changes, it can be determined whether the patient has hypocalcemia. When the patient has severe hypotension during the blood purification process, the blood circuit is immediately controlled to stop flowing to prevent anticoagulation complications from interfering with the patient's blood purification safety. Therefore, the embodiment of the present application can prevent anticoagulation complications from causing damage to the patient's life safety by monitoring the patient's physiological treatment parameters.

[0113] See also Figure 7 , Figure 7 It is a structural diagram of an embodiment of the medical system of the present application, the medical system includes: an infusion pump 4 and a blood purification device; the infusion pump 4 is communicatively connected with the blood purification device, the blood purification device includes: an anticoagulation branch 3, a blood circuit 1 and a blood purifier 2, the blood circuit 1 is used to transmit blood, the anticoagulation branch 3 is connected to the blood circuit 1, the blood purifier 2 is serially connected in the blood circuit 1, and the blood purifier 2 is used to purify blood; the infusion pump 4 is arranged on the anticoagulation branch 3, the infusion pump 4 is used to control the flow state of the anticoagulant in the anticoagulation branch 3; the medical system also includes: a memory 400 and a processor 300, the memory 400 is used to store a computer program; the processor 300 is used to execute the computer program and implement any of the above anticoagulation control methods for the medical system when executing the computer program. For a detailed description of the relevant content, please refer to the relevant content of the anticoagulation control method of the above medical system, which will not be repeated here.

[0114] The blood purification device may further include a host 100 and a display device 200, and the blood circuit 1, the blood purifier 2, and the anticoagulation branch 3 may be installed on the host 100. The infusion pump 4 may be installed on the host 100 or independently. The display device 200, the memory 400, and the processor 300 are connected via a bus, and the memory 400 and the processor 300 may be arranged inside the host 100 or outside the host 100. The display device 200 may be a commonly used touch screen.

[0115] The processor 300 may be a micro control unit, a central processing unit or a digital signal processor, etc.

[0116] The memory 400 may be a Flash chip, a read-only memory, a magnetic disk, an optical disk, a U disk, or a mobile hard disk, etc.

[0117] The present application also provides a computer-readable storage medium, wherein the computer-readable storage medium stores a computer program, and when the computer program is executed by a processor, the processor implements any of the above-mentioned anticoagulation control methods for medical systems. For detailed descriptions of the relevant contents, please refer to the relevant contents of the above-mentioned anticoagulation control methods for medical systems, which will not be repeated here.

[0118] The computer-readable storage medium may be an internal storage unit of the medical system, such as a hard disk or a memory, or an external storage device, such as a plug-in hard disk, a smart memory card, a secure digital card, a flash memory card, etc.

[0119] It should be understood that the terms used in the specification of the present application are only for the purpose of describing specific embodiments and are not intended to limit the present application.

[0120] It should also be understood that the term “and / or” used in the specification and appended claims refers to any and all possible combinations of one or more of the associated listed items, and includes these combinations.

[0121] The above is only a specific embodiment of the present application, but the protection scope of the present application is not limited thereto. Any technician familiar with the technical field can easily think of various equivalent modifications or replacements within the technical scope disclosed in the present application, and these modifications or replacements should be included in the protection scope of the present application. Therefore, the protection scope of the present application should be based on the protection scope of the claims.

Claims

1. A medical system, characterized in that: The medical system comprises: an infusion pump and a blood purification device; the infusion pump is communicatively connected with the blood purification device, the blood purification device comprises: an anticoagulation branch, a blood circuit and a blood purifier, the blood circuit is used to transmit blood, the anticoagulation branch is connected with the blood circuit, the blood purifier is serially connected in the blood circuit, and the blood purifier is used to purify blood; the infusion pump is arranged on the anticoagulation branch, and the infusion pump is used to control the flow state of the anticoagulant in the anticoagulation branch; the medical system further comprises: a memory and a processor, the memory is used to store a computer program; the processor is used to execute the computer program and implement the following anticoagulation control method of the medical system when executing the computer program: When a user's operation indicating blood purification is detected, controlling the blood circuit to transfer blood to purify the blood; Detecting the actual flow rate of blood in the blood circuit, and when the actual flow rate meets a first condition, determining a second flow rate of the anticoagulation branch according to the actual flow rate, and controlling the blood purification device to issue a first control instruction to the infusion pump, wherein the first condition is that a difference between the actual flow rate and the first flow rate is greater than a preset error value, and the first flow rate is a preset blood flow rate of the blood circuit in a normal blood purification process under a currently selected blood purification treatment mode; When the infusion pump receives the first control instruction, the infusion pump controls the anticoagulation branch to output the anticoagulant to the blood circuit at the second flow rate according to the first control instruction; Wherein, the blood circuit includes an arterial line and a venous line, and the blood purifier is connected between the arterial line and the venous line; the infusion pump includes a citric acid pump and a calcium pump, the anticoagulant includes citric acid solution and calcium solution, and the anticoagulant branch includes: a first output branch and a second output branch, the first output branch is connected to the arterial line, and the second output branch is connected to the venous line; the citric acid pump is arranged on the first output branch, and the citric acid pump is used to control the flow state of the citric acid solution in the first output branch; the calcium pump is arranged on the second output branch, and the calcium pump is used to control the flow state of the calcium solution in the second output branch; The processor is used to execute the computer program and implement the following anticoagulation control method for a medical system when executing the computer program: When the citric acid pump receives the first control instruction, the citric acid pump controls the first output branch to output the citric acid solution to the arterial line at the second flow rate according to the first control instruction, and controls the citric acid pump to send a second control instruction to the calcium pump; When the calcium pump receives the second control instruction, the calcium pump controls the second output branch to output the calcium solution to the venous line at a third flow rate according to the second control instruction, wherein the third flow rate is obtained according to the second flow rate; The processor is used to execute the computer program and implement the following anticoagulation control method for a medical system when executing the computer program: Respectively detecting a first temperature of the citric acid solution in the first output branch, a second temperature of the calcium solution in the second output branch, and a safe temperature of the blood in the venous line; When the first temperature, the second temperature and the safety temperature do not meet the second condition, an alarm signal is issued, and the second condition is: the absolute value of the difference between the first temperature and the second temperature is less than the first preset temperature difference, the absolute value of the difference between the safety temperature and the first temperature is less than the second preset temperature difference, and the absolute value of the difference between the safety temperature and the second temperature is less than the third preset temperature difference.

2. The medical system according to claim 1, characterized in that The processor is used to execute the computer program and implement the following anticoagulation control method for a medical system when executing the computer program: detecting the pH value of the blood in the venous line; When the pH value of the blood is greater than a preset pH value, it is determined that metabolic alkalosis occurs in the blood in the venous line.

3. The medical system according to claim 1, characterized in that: The processor is used to execute the computer program and implement the following anticoagulation control method for a medical system when executing the computer program: receiving fluid refilling instructions; The citric acid pump controls the first output branch according to the first control instruction and the fluid infusion instruction to output the mixed solution obtained by mixing the citric acid solution and the replacement fluid to the arterial line at the second flow rate.

4. The medical system according to claim 3, characterized in that: The processor is used to execute the computer program and implement the following anticoagulation control method for a medical system when executing the computer program: The calcium pump controls the second output branch according to the second control instruction to output the calcium solution to the venous line at a calibrated third flow rate, wherein the calibrated third flow rate is obtained after calibration of the third flow rate, and the calibrated third flow rate is less than the third flow rate.

5. The medical system according to claim 3, characterized in that: The processor is used to execute the computer program and implement the following anticoagulation control method for a medical system when executing the computer program: When the flow rate adjustment operation by the user is detected, the actual flow rate of the blood in the blood circuit is adjusted.

6. The medical system according to claim 5, characterized in that: The processor is used to execute the computer program and implement the following anticoagulation control method for a medical system when executing the computer program: When receiving the fluid infusion instruction, setting the blood circuit to a state where the flow rate cannot be changed; When the fluid replenishment instruction is not received, the blood circuit is set to a flow rate changeable state.

7. The medical system according to claim 1, characterized in that: The processor is used to execute the computer program and implement the following anticoagulation control method for a medical system when executing the computer program: Acquire a first cumulative time of continuous blood transmission in the blood circuit and a second cumulative time of anticoagulant output in the anticoagulation branch; When the difference between the first cumulative time and the second cumulative time satisfies the following third condition, the blood purification device is controlled to send out an alarm signal, and the third condition is: the difference between the first cumulative time and the second cumulative time is greater than a preset cumulative time.

8. A computer-readable storage medium, characterized in that: The computer-readable storage medium stores a computer program, and when the computer program is executed by a processor, the processor implements the anticoagulation control method of the medical system as described in any one of claims 1-7.

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