An isolated multi-channel electrical measurement system
By designing an isolated multi-channel electrocardiogram (ECG) measurement system, the problems of insufficient electrical signal acquisition and equipment safety in existing technologies have been solved. This system enables effective acquisition of ECG signals and ensures equipment safety, supporting a variety of experimental needs.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- SCOPE TECHNOLOGY LTD BEIJING
- Filing Date
- 2022-07-06
- Publication Date
- 2026-05-29
AI Technical Summary
Existing electrocardiogram (ECG) systems cannot adapt to the acquisition of large ECG amplitude signals and lack additional channels to simultaneously record additional information from cardiac experiments. The equipment is not safe enough, especially under the electrical stimulation function, there is an additional stimulation risk caused by different ground levels.
An isolated multi-channel electrometric measurement system was designed, including a cell host, a tissue/organ host, and an additional channel host. Analog and digital circuit isolation is achieved through SPI to LVDS conversion. A power isolation module and a high-voltage discharge module are set up. A voltage divider circuit is used to expand the signal acquisition range. Multiple electrode connections are achieved through a universal electrode connector. An additional channel host is added for additional signal acquisition.
It enables effective acquisition of electrocardiogram signals, expands the signal acquisition range, ensures equipment safety, protects experimental animals, supports long-term cell experiments, and meets various experimental needs.
Smart Images
Figure CN115054263B_ABST
Abstract
Description
Technical Field
[0001] This invention relates to the fields of electrophysiology and biomedical engineering technology, and in particular to an isolated multi-channel electrophysiological measurement system. Background Technology
[0002] Electrophysiology mapping is a powerful tool for studying electrophysiology, applicable to neuroscience and cardiology. It simultaneously records both temporal and spatial information of electrical activity, allowing for research at the cellular, tissue, and organ levels. Furthermore, it can record and analyze signals both in vivo and in vitro. Therefore, ensuring experimental safety while maintaining accurate electrical signal acquisition and control is crucial.
[0003] The electrophysiological mapping system is powered by mains electricity and has an electrical stimulation function, requiring electrical isolation to ensure safe operation. Electrical stimulation can effectively modulate electrical signals and is an indispensable tool for research. Although both neurological and cardiac research involve the acquisition of electrical signals, the amplitude and bandwidth of these signals differ. Cardiac research often requires the simultaneous recording of ECG and pressure signals. Therefore, the system must be able to adjust the acquisition range and bandwidth, and also have the ability to record signals from additional channels.
[0004] Most commercially available devices can only meet the requirements of neural data acquisition research and cannot handle the acquisition of large-amplitude electrocardiogram (ECG) signals. Furthermore, they lack additional channels for simultaneously recording extra information during cardiac experiments. Moreover, commercially available devices often only provide power isolation; since these products include electrical stimulation functions, the electrical stimulation itself needs to be isolated to prevent additional stimulation caused by differences in ground levels between the stimulator and the experimental animal, thus protecting the animal's safety. Therefore, an isolated multi-channel electrical mapping system is needed to address these issues. Summary of the Invention
[0005] The purpose of this invention is to address the shortcomings of existing technologies by proposing an isolated multi-channel electrical standard measurement system.
[0006] To achieve the above objectives, the present invention adopts the following technical solution:
[0007] An isolated multi-channel electrical standard measurement system, including
[0008] Cell host, used to record cell electrolabeling signals;
[0009] Organ and tissue host, used to record electrical measurement signals of organs and tissues;
[0010] An additional channel host is used to record common physiological signals such as ECG and stress.
[0011] The PC runs recording software that controls the cell host, tissue and organ host, and additional channel host to perform acquisition tasks, read and store the acquired data.
[0012] The cell host is electrically connected to the tissue / organ host, which powers the cell host. The cell host and the tissue / organ host communicate via SPI to LVDS. The additional channel host is electrically connected to the tissue / organ host for device connection identification. The tissue / organ host and the additional channel host acquire signals synchronously via a clock signal. The tissue / organ host and the additional channel host are connected to the PC via USB cables.
[0013] Preferably, the organ host and the additional channel host are each powered by an independent 12VDC power supply.
[0014] Preferably, the cell host includes an electrode connector, a heating module, and an analog-to-digital converter chip RHS2116. The electrode connector is electrically connected to electrodes for acquiring cell electrolabeling signals. The heating module is electrically connected to a temperature control device to ensure that the ambient temperature of the cells is stable during the recording process. The analog-to-digital converter chip RHS2116 is used to convert electrical signals into digital signals and output constant current electrical stimulation.
[0015] Preferably, the organ and tissue host includes a universal connector, a conditioning circuit, an RHS2116 analog-to-digital converter chip, a power isolation module, an FPGA core board, and a communication module. The universal connector electrically connects electrodes for acquiring organ and tissue electrical mapping signals. The conditioning circuit includes a high-voltage discharge module, ESD protection, and a range switching circuit for processing organ and tissue electrical signals before analog-to-digital conversion. The range switching circuit is implemented through a resistor voltage divider. The RHS2116 analog-to-digital converter chip performs organ and tissue electrical signal analog-to-digital conversion and outputs constant current electrical stimulation. The power isolation module isolates the 12VDC power supply. The FPGA core board processes data from the organ and tissue host and cell host, buffering the data in DDR memory. The communication module connects to a USB port and communicates with a PC.
[0016] Preferably, the additional channel host includes an external preamplifier box and an internal acquisition card, power isolation module, and communication module. The preamplifier box is used to amplify the signal, the acquisition card is used to acquire the amplified electrical signal, the power isolation module is used to isolate the 12VDC power supply, and the communication module is used to connect to USB and communicate with a PC.
[0017] The present invention has the following beneficial effects:
[0018] 1. Power isolation protects the safety of the equipment. Electromagnetic isolation is used in SPI to isolate analog and digital circuits. A high-voltage discharge module is also set in the conditioning circuit to effectively protect the system itself from ESD.
[0019] 2. The signal acquisition range was expanded by using a voltage divider circuit, and multiple electrode connections were achieved through a universal electrode connector. The cell host and tissue / organ host were set up to optimize for different experimental needs.
[0020] 3. Existing equipment can usually only collect electrode signals, but signals such as ECG and blood pressure are very valuable information in cardiac research. This system is designed with an additional channel host to collect various additional signals, making it more adaptable to various needs.
[0021] 4. With its built-in heating module, it can maintain cell viability during long-term cell recording, facilitating long-term experimental research. Attached Figure Description
[0022] Figure 1 This is a schematic diagram of the system block structure of an isolated multi-channel electrical standard measurement system proposed in this invention;
[0023] Figure 2 This is a schematic diagram of the system structure of the cell host proposed in this invention;
[0024] Figure 3 This is a schematic diagram of the system structure of the organ host proposed in this invention;
[0025] Figure 4 This is a schematic diagram of the system architecture of the additional channel host proposed in this invention. Detailed Implementation
[0026] The technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments.
[0027] Reference Figure 1-4 An isolated multi-channel electrolabeling system includes a cell host for recording cell electrolabeling signals;
[0028] Organ and tissue host, used to record electrical measurement signals of organs and tissues;
[0029] An additional channel host is used to record common physiological signals such as ECG and stress.
[0030] The PC runs recording software that controls the cell host, tissue / organ host, and additional channel host to perform acquisition tasks, read and store the acquired data.
[0031] The cell host is electrically connected to the tissue / organ host, which powers the cell host. The cell host and the tissue / organ host communicate via SPI to LVDS, and electromagnetic isolation is used in the SPI to isolate the analog and digital circuits. The additional channel host is electrically connected to the tissue / organ host for device connection identification, and the tissue / organ host and the additional channel host acquire signals synchronously by a clock signal. The tissue / organ host and the additional channel host are connected to the PC via USB cables.
[0032] The organ and tissue host and the additional channel host are each powered by an independent 12VDC power supply.
[0033] The cell host includes an electrode connector, a heating module, and an analog-to-digital converter chip RHS2116. The electrode connector is electrically connected to the electrodes for acquiring cell electrolabeling signals. The heating module is electrically connected to the temperature control device to ensure that the ambient temperature of the cells is stable during the recording process. The analog-to-digital converter chip RHS2116 is used to convert cell electrical signals into digital signals and output constant current electrical stimulation.
[0034] The cell host can simultaneously record electrical signals from 64 channels, with a sampling rate of up to 30kHz per channel and a range of ±5mV. It has a stimulation output function, capable of outputting constant current stimulation from 10nA to 2.55mA, and features stimulation artifact removal.
[0035] For the cell host, signals are acquired by electrodes connected to the electrode connector, converted into digital signals by the RHS2116 analog-to-digital converter chip, converted to LVDS via SPI, and transmitted to the FPGA core board inside the tissue / organ host after electromagnetic isolation. Simultaneously, the RHS2116 has a current stimulation output function, allowing direct stimulation of cells through electrode points.
[0036] The organ and tissue host includes a universal connector, conditioning circuitry, an RHS2116 analog-to-digital converter chip, a power isolation module, an FPGA core board, and a communication module. The universal connector electrically connects to pen electrodes, microelectrode arrays, flexible electrodes, etc., for acquiring organ and tissue electrical mapping signals. The conditioning circuitry includes a high-voltage discharge module, ESD protection, and a range switching circuit for processing organ and tissue electrical signals before analog-to-digital conversion. The range switching circuit is implemented through a resistor voltage divider. The RHS2116 analog-to-digital converter chip performs organ and tissue electrical signal analog-to-digital conversion and outputs constant current electrical stimulation. The power isolation module isolates the 12VDC power supply to protect the safety of the equipment. The FPGA core board processes data from the organ and tissue host and caches the data in DDR memory. The communication module connects to USB and communicates with a PC.
[0037] The organ and tissue main unit can acquire electrical signals from 128 channels, with switchable ranges of 5mV and 50mV, and a maximum sampling rate of 30kHz per channel. It can output constant current electrical stimulation from 10nA to 2.55mA and features stimulation artifact cancellation.
[0038] For the organ and tissue host, the electrodes connected by the universal connector collect electrical measurement signals. Before entering the analog-to-digital converter chip RHS2116, the signals are first processed by the conditioning circuit. The range switching circuit is implemented by the principle of resistor voltage division, scaling signals of different magnitudes to a range of ±5mV, thereby realizing range switching. After passing through the conditioning circuit, the RHS2116 performs analog-to-digital conversion on the signals and transmits them to the FPGA core board via SPI through electromagnetic isolation. The FPGA core board is responsible for processing the data of the organ and tissue host and the cell host, buffering the data in DDR, and communicating with the PC via USB.
[0039] The additional channel host includes an external preamplifier box and an internal acquisition card, power isolation module, and communication module. The preamplifier box is used to amplify the signal, the acquisition card is used to acquire the amplified electrical signal, the power isolation module is used to isolate the 12VDC power supply to protect the safety of the device, and the communication module is used to connect to USB and communicate with a PC.
[0040] The additional channel host can acquire electrical signals from 16 channels, with adjustable ranges from 100mV to 10V. The sampling rate for each channel is up to 30kHz, and it can receive external clock signals for synchronous acquisition.
[0041] Commercially available devices typically only provide power isolation, which still poses risks. This system protects device safety through power isolation and achieves isolation between analog and digital circuits using electromagnetic isolation in SPI. A high-voltage discharge module is also included in the conditioning circuit, effectively protecting the system from ESD.
[0042] Commercially available equipment is typically limited to neurological research; cardiac signals have a large amplitude that exceeds the acquisition range of these devices. Furthermore, the limited range of compatible electrodes prevents research at the tissue and organ levels. This system expands the signal acquisition range through a voltage divider circuit and enables various electrode connections via a universal electrode connector. It has been optimized for different experimental needs by setting up cell and tissue / organ control units.
[0043] Existing equipment can typically only acquire electrode signals, but signals such as ECG and blood pressure are very valuable information in cardiac research. This system, by setting up an additional channel host, is dedicated to acquiring various additional signals, making it more adaptable to various needs.
[0044] The above description is only a preferred embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any equivalent substitutions or modifications made by those skilled in the art within the scope of the technology disclosed in the present invention, based on the technical solution and inventive concept of the present invention, should be covered within the scope of protection of the present invention.
Claims
1. An isolated multi-channel electrical standard measurement system, characterized in that, include: Cell host, used to record cell electrolabeling signals; Organ and tissue host, used to record electrical measurement signals of organs and tissues; An additional channel host is used to record ECG and stress physiological signals; PC, the recording software running on the PC is used to control the cell host, tissue and organ host and additional channel host to perform acquisition tasks, read and store the acquired data; The cell host is electrically connected to the tissue / organ host, which powers the cell host. The cell host and the tissue / organ host communicate via SPI to LVDS. The additional channel host is electrically connected to the tissue / organ host for device connection identification. The tissue / organ host and the additional channel host acquire signals synchronously via a clock signal. The tissue / organ host and the additional channel host are connected to the PC via USB cables.
2. The isolated multi-channel electrical standard measurement system according to claim 1, characterized in that, The organ and tissue host and the additional channel host are each powered by an independent 12V DC power supply.
3. The isolated multi-channel electrical standard measurement system according to claim 1, characterized in that, The cell host includes an electrode connector, a heating module, and an analog-to-digital converter chip RHS2116. The electrode connector is electrically connected to electrodes for acquiring cell electrolabeling signals. The heating module is electrically connected to a temperature control device to ensure that the ambient temperature of the cells is stable during the recording process. The analog-to-digital converter chip RHS2116 is used to convert cell electrical signals into digital signals and output constant current electrical stimulation.
4. The isolated multi-channel electrical standard measurement system according to claim 1, characterized in that, The organ and tissue host includes a universal connector, conditioning circuitry, an RHS2116 analog-to-digital converter chip, a power isolation module, an FPGA core board, and a communication module. The universal connector electrically connects electrodes for acquiring organ and tissue electrical mapping signals. The conditioning circuitry includes a high-voltage discharge module, ESD protection, and a range switching circuit for processing organ and tissue electrical signals before analog-to-digital conversion. The range switching circuit is implemented through a resistor voltage divider. The RHS2116 analog-to-digital converter chip performs organ and tissue electrical signal analog-to-digital conversion and outputs constant current electrical stimulation. The power isolation module isolates the 12V DC power supply. The FPGA core board processes data from the organ and tissue host and cell host, buffering the data in DDR memory. The communication module connects to a USB port and communicates with a PC.
5. The isolated multi-channel electrical standard measurement system according to claim 1, characterized in that, The additional channel host includes an external preamplifier box and an internal acquisition card, power isolation module, and communication module. The preamplifier box is used to amplify the signal, the acquisition card is used to acquire the amplified electrical signal, the power isolation module is used to isolate the 12V DC power supply, and the communication module is used to connect to USB and communicate with a PC.