Packaging for holding and dispensing a delivery shaft assembly for delivery of an implant

Abstract

A package (100) is provided for holding and dispensing a delivery shaft assembly (200) for delivering an implant (230), the package (100) including a vial (400) and an insert (300) mounted within a vial holding space (410), wherein the insert (300) includes: - a force receiving body (308) configured to support an adapter (210) of the delivery shaft assembly (200) during engagement with an inserter tool (500); - a delivery shaft holding mechanism (310) configured to releasably hold the delivery shaft, wherein a force applied by the inserter tool (500) during engagement with the adapter (210) actuates the delivery shaft holding mechanism (310) to release the held delivery shaft (220) for retraction of the delivery shaft assembly (200) from the insert (300) and the vial (400).

Description

Technical Field

[0001] This article provides a package for holding and dispensing a delivery shaft assembly for delivering an implant for implantation in a subject. Background Technology

[0002] Implants are typically used to treat conditions where drug therapy is ineffective or unavailable. The techniques used to place implants generally rely on an inserter tool that temporarily holds the implant and provides the range of extension for placement at the implantation site and a mechanism for ejection. Implants can be very small; for example, implants for treating glaucoma typically have a length of 5 mm and a width of 1 mm. Examples of implants and inserters for treating glaucoma are also disclosed, for example, in WO 2017 / 108498.

[0003] A problem in this field is how to store implants in optimal condition prior to use. Small implants may be difficult to insert precisely just before use. Some implants need to be kept in a liquid reservoir without damage or exposure to cavitation. Summary of the Invention

[0004] This document describes a package (100) for holding and dispensing a delivery shaft assembly (200) for delivering an implant (230), wherein

[0005] - The delivery shaft assembly (200) includes a delivery shaft (220) and an adapter (210), the delivery shaft (220) having a lumen (222) for holding the implant (230), and the adapter (210) being configured for coupling to an inserter tool (500).

[0006] The inserter tool (500) is provided with a discharge shaft (510) configured to be received by the lumen (222) of the delivery shaft assembly, and with an adapter connector (520) configured to connect with an adapter (210), wherein the delivery shaft (220) and / or the discharge shaft (510) are movable to release the implant (230) from the lumen.

[0007] Package (100) includes:

[0008] - A vial (400) and an insert (300) installed within a vial holding space (410), wherein the insert (300) comprises:

[0009] - Force receiving body (308), the force receiving body (308) is configured to support the adapter (210) during connection to the inserter tool (500),

[0010] - A conveyor shaft holding mechanism (310) is configured to hold the conveyor shaft in a releasable manner.

[0011] During connection to the adapter (210), the force applied by the inserter tool (500) actuates the delivery shaft holding mechanism (310) to release the held delivery shaft (220) for retraction of the delivery shaft assembly (200) from the insert (300) and the vial (400).

[0012] The conveyor shaft holding mechanism (310) may include a first body (312) and a second body (314), the first body (312) and the second body (314) being configured to cooperate to clamp at least a portion of the conveyor shaft (220).

[0013] The first body (312) may be configured to be fixed to the force receiving body (308), and the second body (314) may be configured to move at least partially away from the first body (312) when the conveyor shaft holding mechanism (310) is actuated, thereby releasing the held conveyor shaft (220).

[0014] The conveyor shaft holding mechanism (310) may also include an actuating pin (316) and a moving guide (318), wherein a force applied by the inserter tool during engagement causes the pin (316) and the moving guide (318) to advance from the holding position to the release position, wherein the moving guide (318), which is slidably coupled to the second body (314), enables the movement of the second body (314) from the holding position to the release position.

[0015] The movable guide (318) may include at least one guide groove (320) having at least a portion of the cam path, and the second body (314) may include at least one protrusion (322) engaged in the guide groove (320). Movement of the movable guide (318) from a holding position to a releasing position can enable sliding of the guide groove (320) and movement of at least one protrusion (322) along the cam path, thereby separating at least a portion of the second body (314) from the first body (312).

[0016] The first body (312) and the second body (314) can be connected by a hinge, preferably by a movable hinge. The vial holding space (410) can be configured to hold liquid. The vial (400) can have an opening (412) that can be closed by a cap or a removable seal.

[0017] The first body (312) may be provided with a retainer (324) configured to restrict the movement of the implant (230) in the lumen (222) of the delivery shaft (220) along the direction of the distal end (40).

[0018] The retainer may include a protrusion configured to at least partially engage with the lumen (222) of the delivery shaft (220).

[0019] The first body (312) and the second body (314) cooperate to clamp at least a portion of the delivery shaft in the clamping region, such that the delivery shaft lumen (222) in the clamping region (312a, 314a) is at least partially narrowed, thereby restricting the movement of the implant (230) in the proximal (20) direction.

[0020] The insert (300) may also include one or more fluid displacement bodies (340) configured to displace the (aqueous) solution from the vial holding space (410) during insertion of the insert (300) into the vial holding space (410).

[0021] The insert (300) may also include an overflow outlet (342) configured to allow solution displaced from the vial to pass through. The package (100) may also include a delivery shaft assembly (200) as defined herein. Attached Figure Description

[0022] Figure 1 A view of the conveyor shaft assembly as described in this article.

[0023] Figure 2 This is a view of the package as described in this article.

[0024] Figure 3 Sections A through C are a series of views illustrating the actuation of the retaining shaft mechanism and the release of the conveyor shaft assembly.

[0025] Figure 4 The package as described herein is shown, highlighting the clamping portions of the first and second bodies that narrow the conveyor shaft, and a retainer is also shown.

[0026] Figure 5 A portion of the inserter tool as described in this article is shown.

[0027] Figure 6 Sections A through C show a series of views in which the inserter tool is engaged with the delivery shaft assembly, and the retaining shaft mechanism is actuated to release the delivery shaft assembly.

[0028] Figure 7 Parts A and B show the inserter tool in the preparation (part A) and deployment (part B) configurations.

[0029] Figure 8 A package further configured with multiple liquid transducers, as described herein, is depicted. Detailed Implementation

[0030] Before describing the systems and methods of the present invention, it should be understood that the invention is not limited to the specific systems, methods, or combinations described, as such systems, methods, and combinations can certainly be modified. It should also be understood that the terminology used herein is not intended to be limiting, as the scope of the invention will be limited only by the appended claims.

[0031] As used herein, the singular forms “a,” “an,” and “the” include both singular and plural indicators, unless the context clearly specifies otherwise.

[0032] As used herein, the terms “comprising,” “including,” and “consisting of” are synonymous with “containing,” “comprising,” or “containing,” and are inclusive or open-ended, and do not exclude additional, unlisted components, elements, or method steps. It should be understood that the terms “comprising,” “including,” and “consisting of” as used herein include the terms “composed of,” “consisting of,” and “containing.”

[0033] The range of values ​​referenced by an endpoint includes all numbers and fractions contained within the corresponding range, as well as the endpoints referenced.

[0034] As used herein, the terms “about” or “approximately” when referring to measurable values ​​such as parameters, quantities, durations, etc., are intended to include a specified value and variations relative to that specified value of + / -10% or less, preferably + / -5% or less, more preferably + / -1% or less, and even more preferably + / -0.1% or less, provided such variations are suitable for implementation in the disclosed invention. It should be understood that the values ​​referred to by the modifier “about” or “approximately” are themselves specific and preferably disclosed.

[0035] Although the terms “one or more” or “at least one”, such as one or more or at least one of a group of components, are self-explanatory, by further illustration, the terms particularly include reference to any one of the components or reference to any two or more of the components, such as, for example, any ≥3, ≥4, ≥5, ≥6 or ≥7 of the components, and up to all of the components.

[0036] All references cited in the text of this application are incorporated herein by reference in their entirety. In particular, the teachings of all references specifically mentioned herein are incorporated herein by reference.

[0037] Unless otherwise specified, all terms used in disclosing this invention, including technical and scientific terms, have the meaning commonly understood by one of ordinary skill in the art to which this invention pertains. Further guidance, including terminology definitions, is provided to better understand the teachings of this invention.

[0038] The various aspects of the invention are defined in more detail in the following paragraphs. Each aspect thus defined may be combined with any other one or more aspects unless otherwise expressly indicated. In particular, any feature indicated as preferred or advantageous may be combined with any other one or more features indicated as preferred or advantageous.

[0039] Throughout the text of this application, references to "one embodiment" or "implementation" mean that a particular feature, structure, or characteristic described in connection with that embodiment is included in at least one embodiment of the invention. Therefore, the phrases "in one embodiment" or "in an embodiment" appearing in various places throughout the text of this application do not necessarily refer to the same embodiment, but may refer to the same embodiment. Furthermore, in one or more embodiments, specific features, structures, or characteristics may be combined in any suitable manner, as will be apparent to those skilled in the art from this disclosure. Moreover, while some embodiments described herein include features of other embodiments but not others in other embodiments, combinations of features from different embodiments are intended to be within the scope of the invention and form different embodiments, as will be understood by those skilled in the art. For example, any embodiment of the claimed embodiments in the appended claims may be used in any combination.

[0040] In this specification of the invention, reference is made to the accompanying drawings, which form a part of the invention, and specific embodiments in which the invention can be practiced are shown only by way of illustration. The bracketed or bolded reference numerals attached to the various elements illustrate the elements by way of example only, and are not intended to limit the elements. It should be understood that other embodiments can be utilized and structural or logical changes can be made without departing from the scope of the invention. Therefore, the following detailed description should not be construed as limiting, and the scope of the invention is defined by the appended claims.

[0041] Throughout the text of the application documents, the terms “distal” or “away” and “proximal” or “near” are used, and these terms are generally understood in the art to refer to the user (practitioner) side toward (near) or away from (away from) the device. Therefore, “proximal” or “near” means toward the user side and thus away from the subject (patient) side. Conversely, “distal” or “away” means toward the subject side and thus away from the user side. The term “subject” refers to a person or animal receiving the implant. The term “user” refers to a person performing the implantation (e.g., surgeon, specialist, practitioner).

[0042] For example in Figure 1 and Figure 2As illustrated herein, this document provides a package (100) for holding and dispensing a delivery shaft assembly (200) for delivering an implant (230). The package (100) includes a vial (400) and an insert (300) mounted within a vial holding space (410). The vial holding space (410) is typically provided with liquid to hold the implant (230) in, for example, a hydrated state for implantation. The insert (300) includes a force-receiving body (308) configured to support an adapter (210) of the delivery shaft assembly (200) during engagement with an inserter tool (500). The insert (300) also includes a shaft retaining mechanism (310) configured to releasably retain the delivery shaft (220) of the delivery shaft assembly (200). The shaft holding mechanism (310) is configured such that the force applied by the inserter tool (500) during coupling to the adapter (210) actuates the shaft holding mechanism (310) to release the held delivery shaft (220) for retraction of the delivery shaft assembly (200) from the insert (300) and the vial (400).

[0043] Advantageously, the package (100) stabilizes the position of the delivery shaft assembly (200) within the vial (400) during transport and storage, thereby preventing accidental loss of the implant from the delivery shaft due to transport and handling agitation. The delivery shaft assembly (200) is held in the vial holding space (410) and allows liquid to rise until the moment of use by associating the release or holding state of the shaft holding mechanism (310) with a force applied by the inserter tool (500), and the delivery shaft assembly (200) is released from the inserter (300) upon engagement of the inserter tool therewith. The package (100) may or may not include the delivery shaft assembly (200). The package (100) may or may not include the inserter tool (500).

[0044] The delivery shaft assembly (200) includes an adapter (210) and a delivery shaft (220). The delivery shaft (220) is provided with a lumen (222) for holding an implant (230) and an adapter (210) configured for coupling to an inserter tool (500). The implant (230) is disposed at or toward the distal end (40) of the delivery shaft (220). The adapter (210) is disposed at the proximal end (20) of the delivery shaft (220). The adapter (210) has a body provided with a receiving space (212) for a portion of the inserter tool (500) and an orifice (214) for connecting the receiving space (212) to the lumen (222) of the delivery shaft (220). The lumen (222) is configured to allow a discharge shaft (510) of the inserter tool (500) to pass through it. The implant (230) can be ejected from the delivery shaft (220) by actuation of the inserter tool (500), thereby delivering the implant (230) to the target. An exemplary delivery shaft assembly (200) is disclosed in WO 2017 / 108498, which is incorporated herein by reference.

[0045] The inserter tool (500) is provided with a discharge shaft (510) configured to be received by the lumen (220) of the delivery shaft assembly. The discharge shaft (510) may be configured to be adjacent to the implant (230). Movement of the delivery shaft (220) and / or the discharge shaft (510) causes the implant (230) to be released from the lumen (222).

[0046] Advancement of the discharge shaft (510) in the distal (40) direction can apply force to the implant (230), thereby ejecting the implant (230) from the shaft assembly lumen (220). Alternatively or additionally, retraction of the delivery shaft (220) relative to the stationary discharge shaft (510) causes the implant (230) to eject from the shaft assembly lumen (220).

[0047] The inserter tool (500) is provided with an adapter connector (520) configured to connect with the adapter (210). The connection between the adapter connector (520) and the adapter (210) can be releasable or non-releasable. For example, a non-releasable connection can be achieved by providing a compliant member on one of the adapter connector (520) or the adapter (210) and a reciprocating stop member on the other, wherein the compliant member slides on the stop member in one direction during connection of the parts (520, 210) and engages with the stop member in another sliding direction to prevent release of the parts (520, 210). This mechanism is similar to the unidirectional movement of a ratchet mechanism.

[0048] When the implant is ejected by retracting the delivery shaft (220) relative to the fixed discharge shaft (510), the adapter connector (520) is slidable relative to the fixed discharge shaft (510). The slidable adapter connector (520) has ready and deployment positions. In the ready position, the slidable adapter connector (520) positions the adapter (210) and the delivery shaft lumen (222) at their furthest points. The fixed discharge shaft (510) may abut the implant (230) and the delivery shaft lumen (222) may cover the implant (230). In the deployment position, the slidable adapter connector (520) positions the adapter (210) and the delivery shaft lumen (222) at their closest points. The discharge shaft (510) abuts the implant (230) and the delivery shaft lumen (222) is retracted in the proximal (20) direction and the implant (230) is released. When the implant is ejected by the advance of the discharge shaft (510), the discharge shaft (510), which is slidable relative to the fixed adapter connector (520), applies an ejection force to the implant (230) in the distal direction, thereby ejecting the implant (230) from the lumen (222).

[0049] Figure 5 An example of a portion of the inserter tool (500) is provided, showing an inserter housing or chassis (550) (fixed) and a slidable adapter connector (520) configured to engage with an adapter (210) of the delivery shaft assembly (200). The discharge shaft (510) is configured to be fixed to the housing (550). When the adapter (210) is engaged in the adapter connector (520), the delivery shaft assembly (200) can be lifted from the package (100) while the movement guide (318) is in the released position. In this example, the adapter connector (520) is slidable relative to the housing (550) and is shown in a ready position; it should be understood that other configurations of the inserter tool (500) exist, for example, in which the adapter connector (520) is configured to be fixed to the inserter tool housing and the discharge shaft (510) is slidable.

[0050] Figure 7A portion of an inserter tool (500) is illustrated, showing the inserter housing or chassis (550) (fixed) and a slidable adapter connector (520) connected to an adapter (210) of the delivery shaft assembly (200). In section A, the inserter tool (500) is shown in a ready position; the adapter connector (520) is in a distal (40) position. In the ready position, the implant (230) is held in the delivery shaft lumen (222). In section B, the inserter tool (500) is shown in a deployment position; the adapter connector (520) is retracted to a proximal (20) position. In the deployment position, the delivery shaft is retracted, thereby releasing the implant (230) from the delivery shaft lumen (222).

[0051] An exemplary inserter tool (500) is disclosed in WO 2017 / 108498, which is incorporated herein by reference.

[0052] The shaft retaining mechanism (310) can have a retaining state (in which the conveyor shaft (222) and therefore the conveyor shaft assembly (200) are securely held by the shaft retaining mechanism (310)) and a released state (in which the conveyor shaft (222) and therefore the conveyor shaft assembly (200) are without the insert (300)). During coupling to the adapter (210), the movement from the retaining state to the released state is actuated by the force of the inserter tool (500). An exemplary shaft retaining mechanism (310) in Figure 2 , Figure 3 A to C Figure 4 As shown in the image.

[0053] The shaft retaining mechanism (310) may include a first body (312) and a second body (314), the first body (312) and the second body (314) being configured (in the retaining state) to cooperate in clamping at least a portion of the conveying shaft (222). The conveying shaft (222) may be clamped in a fixed relationship with the force receiving body.

[0054] The first body (312) and the second body (314) can cooperate in a held state to clamp at least a portion of the delivery shaft in clamping regions (312a, 314a), such that the delivery shaft lumen (222) in the clamping regions is at least partially narrowed, thereby restricting movement of the implant (230) in the proximal (20) direction. The exemplary clamping regions (312a, 314a) that narrow the delivery shaft lumen (222) are... Figure 4 As shown in the image.

[0055] The first body (312) may be configured to be fixed (non-movable) to the force receiving body (308). The second body (314) may be configured to move at least partially away from the first body (312) when the shaft holding mechanism (310) is actuated, thereby releasing the held conveyor shaft (220).

[0056] The first body (312) and the second body (314) can be longitudinal. The first body (312) and the second body (314) can be longitudinal in the proximal-distal direction. The first body (312) and the second body (314) can be connected by a hinge (e.g., a movable hinge).

[0057] The shaft retaining mechanism (310) may further include an actuating pin (316) and a moving guide (318). The actuating pin (316) may be fixedly attached to the moving guide (318). During engagement, a force applied by the inserter tool (500) advances the pin (316) and the moving guide (318) from the retaining position to the releasing position. The moving guide (318), which is slidably coupled to the second body (314), enables the movement of the second body (314) from the retaining position to the releasing position.

[0058] The movable guide (318) includes at least one or two or more (preferably two) guide slots (320) having at least a portion of a cam path. The cam path is a linear cam that converts linear motion along a first direction (e.g., a proximal-distal direction) into linear motion along a second direction (e.g., a direction perpendicular to the first direction).

[0059] The second body (314) may include a protrusion (322) engaging in a guide groove (320). Each guide groove (320) may have one protrusion (322). The protrusion (322) may be fixedly associated with the second body. The protrusion (322) may be a follower for a cam path.

[0060] The movement of the movable guide (318) from the holding position to the releasing position enables the sliding of the guide groove (320) (along the first direction) and the movement of the protrusion (322) along the cam path (along the second direction), thereby separating at least a portion of the second body (314) from the first body (312).

[0061] Figure 3Parts A through C illustrate a package (100) equipped with a conveyor shaft assembly (200) as described herein, illustrating the steps of activating the shaft retaining mechanism (310) to move it from a retained state (part A) to a released state (parts B and C). In part A, the shaft retaining mechanism (310), in the retained state, clamps the conveyor shaft (220) between a first body (312) and a second body (314). In part B, a downward force (proximal to distal) (317) applied to the actuating pin (316) causes the moving guide (318) to shift in a downward direction. Lateral (319) displacement of the protrusion (322) or follower (322) engaged in the guide groove (320) causes the second body to move in a lateral direction, thereby moving the shaft retaining mechanism (310) to the released state. The conveyor shaft assembly (200) is released, and the conveyor shaft assembly (200) can be withdrawn (205) from the insert (300) and thus from the package (100) (part C).

[0062] Figure 6 Sections A through C illustrate a package (100) equipped with a conveyor shaft assembly (200) as described herein, illustrating the steps of activating the shaft retaining mechanism (310) to move it from a retaining state (section A) to a released state (section B), engaging the adapter connector (520) with the adapter (210) (section B), and retracting the conveyor shaft assembly (200) from the package (100) (section C). In section A, the adapter connector (520) is in the ready position, and the discharge shaft (510) is inserted into the conveyor shaft cavity (222). In section B, the inserter housing (550) pushes down the actuating pin (316), thereby actuating the moving guide (318), causing the second body (314) to move to the released position. In section B, the inserter adapter connector (520) in the ready position is engaged with the conveyor shaft assembly adapter (210). The adapter (210) is supported at its distal end by a force-receiving surface (308), while the inserter adapter connector (520) presses downward (in the distal direction) against the adapter (210) to achieve engagement. In part C, with the inserter adapter connector (520) still in the ready position and the shaft retaining mechanism (310) in the released position, the delivery shaft assembly (200) can be withdrawn from the package (100) engaged with the inserter tool (500).

[0063] A first body (312) or a second body (314), preferably the first body (312), may be provided with a retainer (324). The retainer may be configured to be fixed (immovable) to the first body (312) or the second body (314), respectively. The retainer (324) is configured to cooperate with the distal tip of the delivery shaft (220) to restrict movement of the implant (230) in the direction of the distal end (40). The retainer (324) may include a protrusion (e.g., a tapered protrusion) configured to at least partially engage with the lumen (222) of the delivery shaft (220). The retainer (324) may be a solid body extending laterally (perpendicular to the proximal-distal direction). Figure 4 A retainer (324) is illustrated, which is attached to the distal end (40) of the first body (312). The retainer (324) covers the distal end (40) of the delivery shaft lumen (222) and retains the implant (230) by blocking the distal (40) channel of the implant (230). The retainer (324) restricts the movement of the implant in the distal direction (40).

[0064] The insert (300) may also include one or more fluid displacement bodies (340). The fluid displacement bodies (340) are configured to displace liquid from the vial holding space (410) during assembly of the package (100) and placement of the insert (300). This allows the vial holding space (410) to be filled with minimal air bubbles. The fluid displacement bodies (340) may have an annular appearance. The insert (300) may also include an overflow outlet (342) configured to allow liquid displaced from the vial to pass through. The overflow outlet (342) may extend as a channel in the proximal direction into one or more fluid displacement bodies (340). Figure 8 A plurality of liquid displacement bodies (340) and an overflow outlet (342) are shown disposed at the proximal end (20) of the insert (300), through which excess liquid is discharged from the holding space (410).

[0065] The vial (400) may be formed from a vial body (402) defining a vial holding space (410). The vial holding space (410) is configured to hold a liquid, such as an aqueous solution or an organic solvent. The vial (400) has an opening (412) located at a proximal end (20) configured to receive the distal portion of an inserter tool (500). The opening (412) may be closed by a cap or a removable seal. The vial (400) may be provided with one or more support members (420) configured to support the inserter (300). The support members (420) are configured to restrict movement of the inserter (300) in the distal end (40) direction. In particular, the support members (420) prevent movement and damage to the inserter (300) when the inserter tool (500) applies force to the force receiving surface (308). The support member (420) can be positioned as a ridge on the vial body (402) that engages with the force-receiving body (308). An exemplary vial... Figure 2 It is shown in detail in the text.

[0066] The implant (230) can be any implantable device that can be placed in the body of a subject (animal, human) using an inserter tool. In particular, the implant (230) can be an implant for the treatment of glaucoma. In particular, the implant (230) can be an intraocular shunt. The implant (230) can be implanted between the sclera and the choroid, i.e., implanted in the suprachoroidal space. The implant (230) is an implant as described in WO 2017 / 108498. In particular, the implant can be as described on page 13, line 1 to page 14, line 5 and / or on page 21, line 25 to page 22, line 21 of WO 2017 / 108498, which is incorporated herein by reference.

[0067] The inserter tool (500) may be an implantation device as described in WO 2017 / 108498. The delivery shaft assembly (200) may include a one-touch fitting connection element or adapter (210) as described in WO 2017 / 108498. For example, WO 2017 / 108498 describes an implantation device (500) and a delivery shaft assembly (200) on pages 26 to 33, which are incorporated herein by reference.

Claims

1. A package (100) for holding and dispensing a delivery shaft assembly (200) for delivering an implant (230), wherein - The delivery shaft assembly (200) includes a delivery shaft (220) and an adapter (210), the delivery shaft (220) having a lumen (222) for holding the implant (230) and the adapter (210) being configured for coupling to an inserter tool (500). - The inserter tool (500) is provided with a discharge shaft (510) configured to be received by the lumen (222) of the delivery shaft assembly, and is provided with an adapter connector (520) configured to be connected to the adapter (210), wherein, The delivery shaft (220) and / or the discharge shaft (510) are movable, allowing the implant (230) to be released from the lumen. The package (100) includes: - A vial (400) and an insert (300) installed within a vial holding space (410), wherein the insert (300) comprises: - Force receiving body (308) configured to support the adapter (210) during connection to the inserter tool (500). - A conveyor shaft holding mechanism (310) configured to releasably hold the conveyor shaft. During connection to the adapter (210), the force applied by the inserter tool (500) actuates the delivery shaft holding mechanism (310) to release the held delivery shaft (220) for retraction of the delivery shaft assembly (200) from the insert (300) and the vial (400). The conveyor shaft holding mechanism (310) includes a first body (312) and a second body (314), the first body (312) and the second body (314) being configured to cooperate in clamping at least a portion of the conveyor shaft (220), and The first body (312) is fixed to the force receiving body (308), and the second body (314) is configured to move at least partially away from the first body (312) when the conveyor shaft holding mechanism (310) is actuated, thereby releasing the held conveyor shaft (220).

2. The packaging (100) according to claim 1, wherein, The conveyor shaft holding mechanism (310) further includes an actuating pin (316) and a moving guide (318), wherein the force applied by the inserter tool during engagement causes the pin (316) and the moving guide (318) to advance from a holding position to a releasing position, wherein the moving guide (318), which is slidably coupled to the second body (314), enables the movement of the second body (314) from the holding position to the releasing position.

3. The packaging (100) according to claim 2, wherein - The moving guide (318) includes at least one guide groove (320) having at least a portion of the cam path. - The second body (314) includes at least one protrusion (322) that engages in the guide groove (320). - The movement of the movable guide (318) from the holding position to the releasing position enables the sliding of the guide groove (320) and the movement of the at least one protrusion (322) along the cam path, thereby separating at least a portion of the second body (314) from the first body (312).

4. The packaging (100) according to claim 1, wherein, The first body (312) and the second body (314) are connected by a hinge.

5. The packaging (100) according to claim 4, wherein, The hinge is a movable hinge.

6. The packaging (100) according to claim 1, wherein, The first body (312) is provided with a retainer (324) configured to restrict the movement of the implant (230) in the lumen (222) of the delivery shaft (220) along the direction of the distal end (40).

7. The packaging (100) according to claim 6, wherein, The retainer includes a protrusion configured to at least partially engage with a lumen (222) of the transport shaft (220).

8. The package (100) according to any one of claims 1 to 7, wherein, The first body (312) and the second body (314) cooperate to clamp at least a portion of the delivery shaft in the clamping region, such that the lumen (222) of the delivery shaft in the clamping region (312a, 314a) is at least partially narrowed, thereby restricting the movement of the implant (230) in the proximal (20) direction.

9. The package (100) according to any one of claims 1 to 7, wherein, The vial holding space (410) is configured to hold liquid.

10. The package (100) according to any one of claims 1 to 7, wherein, The vial (400) has an opening (412) that can be closed by a cap or a removable seal.

11. The package (100) according to any one of claims 1 to 7, wherein, The insert (300) also includes one or more fluid displacement bodies (340) configured to displace a solution from the vial holding space (410) during insertion of the insert (300) into the vial holding space (410).

12. The packaging (100) according to claim 11, wherein, The solution is an aqueous solution.

13. The packaging (100) according to claim 11, wherein, The insert (300) also includes an overflow outlet (342) configured to allow solution displaced from the vial to pass through.

14. The package (100) according to any one of claims 1 to 7, further comprising the conveyor shaft assembly (200) according to claim 1.

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