Small multi-stage emulsification device

Abstract

The present application relates to a kind of small multi-stage emulsification device, comprising: at least three circulating devices and at least two emulsification membranes, circulating device includes circulating body and valve, circulating body is provided with flow channel, operating interface, cover end and base end, the opposite ends of flow channel are communicated with cover end and base end respectively, valve and operating interface are between cover end and base end, and valve and operating interface are communicated with flow channel, valve can control the opening and closing of flow channel flow, operating interface can be connected with injection device, the cover end of one circulating device can be connected with the base end of another circulating device and form cavity, multiple micropores are provided on emulsification membrane, emulsification membrane is arranged in cavity, and the raw material in the flow channel of one circulating device can flow into the flow channel of another circulating device through the micropore of emulsification membrane.This small multi-stage emulsification device can form multiple emulsification operations, realize successive stage sufficient emulsification.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of emulsifying devices, in particular to a small multi-stage emulsifying device. BACKGROUND

[0002] According to the needs of industry or life, two or more mutually insoluble liquid substances are usually emulsified, and the raw material components of the liquid substances can be prepared in advance according to a formula, or can be chemical products, natural liquid substances or natural biological materials, and the final emulsion product is obtained by mixing device emulsification.

[0003] Traditional emulsification methods mainly include grinding method, syringe injection method and ultrasonic oscillation method. These emulsification methods usually require a long time, and in the emulsification process, the antigen structure is easily damaged or the biological material is denatured, and only single-stage emulsification can be achieved, that is, after completing single emulsification, the product after initial emulsification cannot be emulsified with other liquid raw materials. SUMMARY

[0004] Therefore, it is necessary to provide a small multi-stage emulsifying device capable of forming multi-stage emulsification operation and realizing emulsification step by step to solve the problem that the current emulsifying device cannot realize multi-stage emulsification.

[0005] A small multi-stage emulsifying device comprises at least three circulating devices and at least two emulsifying membranes. The circulating device comprises a circulating body and a valve. The circulating body is provided with a flow channel, an operation interface, a cover end and a base end. The opposite ends of the flow channel are in communication with the cover end and the base end, respectively. The valve and the operation interface are located between the cover end and the base end, and are in communication with the flow channel. The valve can control the opening and closing of the flow channel. The operation interface can be externally connected to an injection device. The cover end of one circulating device can be connected to the base end of another circulating device to form a cavity. The emulsifying membrane is provided with a plurality of micropores. The emulsifying membrane is arranged in the cavity, and the raw material in the flow channel of one circulating device can flow into the flow channel of another circulating device through the micropores of the emulsifying membrane.

[0006] The small multi-stage emulsification device can inject various liquid raw materials into the flow channels of the circulating bodies through the operation interfaces of the injection devices. When first-stage emulsification is needed, the valve between the first operation interface and the second operation interface is opened, the injected liquid raw materials flow into the adjacent flow channels through the emulsification membranes of the respective flow channels, and the liquid raw materials injected by the two operation interfaces are repeatedly mixed and emulsified through the repeated push-pull of the injection devices. When the emulsion has no stratification phenomenon, the emulsified emulsion is pushed into the injection device of the second operation interface, and the first-stage emulsification is completed. When second-stage emulsification is needed, the valve between the first operation interface and the second operation interface is closed, and the valve between the second operation interface and the third operation interface is opened. The above operation is repeated to complete the second-stage emulsification. According to the needs, multiple circulating devices can be arranged to complete more than two stages of emulsification operation, which is fast and convenient, and the liquid raw materials are emulsified through the emulsification membranes with micropores, so that the antigen structure or protein structure in the liquid raw materials is not damaged.

[0007] In one of the embodiments, the valve comprises a valve body and a valve rod. The valve body is hollow inside and communicates with the flow channel. The valve rod is in sliding or threaded connection with the valve body and can extend into the flow channel to block the flow channel or can withdraw from the flow channel to make the flow channel flow. According to the needs of emulsification stages, the opening and closing of the flow channel can be quickly and effectively realized.

[0008] In one of the embodiments, the circulating bodies are in arc shape, and the circulating devices are connected in a ring shape.

[0009] In one of the embodiments, the pore size of each emulsification membrane gradually decreases in the clockwise direction or the counterclockwise direction. This arrangement can make the mixing more and more sufficient during the successive stages of emulsification, and the emulsion diameter of the final product can be as small as 100 nm. Therefore, the pore size of the emulsification membrane can be selected according to the requirements of the emulsion droplet diameter of the final product.

[0010] In one of the embodiments, the base end is recessed to form an accommodation cavity, and the cover end is inserted into the accommodation cavity.

[0011] In one of the embodiments, a first matching cavity is recessed in the inner bottom wall of the accommodation cavity, a second matching cavity is recessed in the end face of the cover end, the first matching cavity and the second matching cavity communicate to form the cavity, and the emulsification membranes abut against the inner bottom wall of the accommodation cavity and the end face of the cover end, respectively.

[0012] In one of the embodiments, the first matching cavity is provided with a first flange, the second matching cavity is provided with a second flange, and the first flange and the second flange are respectively in abutment with two side surfaces of the emulsification film. The emulsification film is usually made of a high polymer material, and the first flange and the second flange support the emulsification film to prevent the emulsification film from deforming and affecting the emulsification effect during the emulsification process.

[0013] In one of the embodiments, the base end, the cover end and the emulsification film are circular, the first flange and the second flange are circular ridges and are provided with a plurality of ridges, the plurality of first flanges are spaced along the radial direction of the base end, and the plurality of second flanges are spaced along the radial direction of the cover end. The liquid raw material can pass through the emulsification film well, and stable support can be formed on each position of the emulsification film.

[0014] In one of the embodiments, the position of the first flange is opposite to the position of the second flange; and / or

[0015] The first matching cavity is provided with a first groove body extending along the radial direction of the base end, and each of the first flanges is cut into two segments, and the second matching cavity is provided with a second groove body extending along the radial direction of the cover end, and each of the second flanges is cut into two segments.

[0016] In one of the embodiments, the middle part of the base end is provided with a first hole in communication with the flow channel, the middle part of the cover end is provided with a second hole in communication with the flow channel; and / or after the connection of each of the circulating devices, the valve is provided between the two operation interfaces. BRIEF DESCRIPTION OF DRAWINGS

[0017] Figure 1 FIG. 1 is a structural schematic diagram of one embodiment of a small multi-stage emulsification device according to the present application;

[0018] Figure 2 FIG. 2 is an exploded structural schematic diagram of the small multi-stage emulsification device shown in FIG. 1; Figure 1

[0019] Figure 3 FIG. 3 is a sectional view of the small multi-stage emulsification device shown in FIG. 1; Figure 1

[0020] Figure 4 FIG. 4 is a matching structural schematic diagram between two circulating devices according to the present application;

[0021] In the drawings, the components represented by each reference numeral are listed as follows:

[0022] ​​100, Small multi-stage emulsification device; 1, Circulation device; 11, Circulation body; 111, Flow channel; 112, Operation interface; 113, Cover end; 1131, Second matching cavity; 1132, Second flange; 1133, Second groove; 1134, Second hole; 114, Base end; 1141, Containing cavity; 1142, First matching cavity; 1143, First flange; 1144, First groove; 1145, First hole; 12, Valve; 121, Valve body; 122, Valve rod; 2, Emulsification film. DETAILED DESCRIPTION

[0023] In order to make the above objectives, features and advantages of the present application more apparent, clear and complete, the specific embodiments of the present application will be described below with reference to the accompanying drawings. Obviously, the specific details of the following description are only some embodiments of the present application, and the present application can be implemented in many other embodiments different from those described herein. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor are within the scope of protection of the present application.

[0024] It should be noted that when an element is referred to as being "fixed" to another element, it can be directly on the other element or there can be an intervening element. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or there can be an intervening element. The terms "vertical", "horizontal", "left", "right" and similar expressions used herein are for illustrative purposes only and are not intended to be the only implementation.

[0025] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. The terminology used in the description herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the application.

[0026] Please refer to Figure 1 , Figure 2 and Figure 3In an embodiment, a small multi-stage emulsification device 100 comprises at least three circulation devices 1 and at least two emulsification membranes 2. The circulation device 1 comprises a circulation body 11 and a valve 12 arranged on the circulation body 11. The circulation body 11 is provided with a flow channel 111, an operation interface 112, a cover end 113 and a base end 114, the opposite ends of the flow channel 111 are communicated with the cover end 113 and the base end 114 respectively, the valve 12 and the operation interface 112 are located between the cover end 113 and the base end 114, and the valve 12 and the operation interface 112 are communicated with the flow channel 111. The valve 12 can control the opening and closing of the flow channel 111, and the operation interface 112 can be externally connected to an injection device. The cover end 113 of one circulation device 1 can be connected with the base end 114 of another circulation device 1 to form a cavity, the emulsification membrane 2 is provided with a plurality of micro-holes penetrating through the emulsification membrane 2, the emulsification membrane 2 is arranged in the cavity, and the raw material in the flow channel 111 of one circulation device 1 can flow into the flow channel 111 of another circulation device 1 through the micro-holes of the emulsification membrane 2.

[0027] The small multi-stage emulsification device 100 can inject various liquid raw materials into the flow channel 111 of each circulation body 11 through the operation interface 112 of the injection device. When first-stage emulsification is needed, the valve 12 between the first operation interface 112 and the second operation interface 112 is opened, the injected liquid raw materials flow into the adjacent flow channel 111 through the emulsification membrane 2 from the respective flow channel 111, and the liquid raw materials injected by the two operation interfaces 112 are repeatedly mixed and emulsified by repeatedly pushing and pulling the injection device. When the emulsion has no stratification phenomenon, the emulsified emulsion is pushed into the injection device of the second operation interface 112 to complete the first-stage emulsification. When second-stage emulsification is needed, the valve 12 between the first operation interface 112 and the second operation interface 112 is closed, the valve 12 between the second operation interface 112 and the third operation interface 112 is opened, and the above operation is repeated to complete the second-stage emulsification. Multiple circulation devices 1 can be arranged according to needs to complete more than two stages of emulsification operation, which is fast and convenient, and the liquid raw materials are emulsified through the emulsification membrane 2 with micro-holes, so that the antigen structure or protein structure in the liquid raw materials is not damaged.

[0028] Please refer to Figure 1 and Figure 2 In an embodiment, the valve 12 comprises a valve body 121 and a valve rod 122, the valve body 121 is hollow inside, and one end of the valve body 121 is communicated with the flow channel 111. The valve rod 122 is slidably or threadedly connected with the valve body 121, the valve rod 122 can be slid into or screwed into the flow channel 111 to block the flow channel 111, and the valve rod 122 can be slid out of or screwed out of the flow channel 111 to make the flow channel 111 flow. According to the needs of emulsification stages, the opening and closing of the flow channel 111 can be quickly and effectively realized.

[0029] In another embodiment, the circulation body 11 is arc-shaped, and each circulation device 1 is connected in a ring shape, so that multi-stage emulsification can be conveniently performed. Further, the pore size of each emulsification film 2 gradually decreases in the clockwise direction or the counterclockwise direction, so that the mixing becomes more and more sufficient during the successive stages of emulsification, and the emulsion diameter of the final product can be as small as 100 nm. Therefore, the pore size of the emulsification film 2 can be selected according to the requirement of the emulsion droplet diameter of the final product.

[0030] Referring to Figure 2 and Figure 3 In an embodiment of the cooperation structure of the base end 114 and the cover end 113, the base end 114 is concave to form a receiving cavity 1141, and the cover end 113 is inserted into the receiving cavity 1141 to form an inclusive connection structure, so that the liquid raw material is less likely to leak.

[0031] Referring to Figure 2 Further, the inner side bottom wall of the receiving cavity 1141 is concave to form a first cooperation cavity 1142, and the end face of the cover end 113 is concave to form a second cooperation cavity 1131. The first cooperation cavity 1142 and the second cooperation cavity 1131 communicate to form a cavity, and the emulsification film 2 abuts against the inner side bottom wall of the receiving cavity 1141 and the end face of the cover end 113, respectively.

[0032] Referring to Figure 3 and Figure 4 In consideration of the stability of the emulsification film 2, the inner side bottom wall of the first cooperation cavity 1142 is protruded to form a first flange 1143, and the inner side bottom wall of the second cooperation cavity 1131 is protruded to form a second flange 1132. The first flange 1143 and the second flange 1132 abut against the two side faces of the emulsification film 2, respectively. The emulsification film 2 is usually made of a high polymer material, and the first flange 1143 and the second flange 1132 support the emulsification film 2 to prevent the deformation of the emulsification film 2 during the emulsification process, thereby affecting the emulsification effect.

[0033] In other embodiments, the base end 114, the cover end 113 and the emulsification film 2 are circular, the first flange 1143 and the second flange 1132 are circular and are provided in multiple strips, the multiple first flanges 1143 are spaced along the radial direction of the base end 114, and the multiple second flanges 1132 are spaced along the radial direction of the cover end 113. The liquid raw material can pass through the emulsification film 2 well, and the emulsification film 2 can be stably supported at different positions.

[0034] The position of the first flange 1143 and the position of the second flange 1132 can be opposite, so that the first flange 1143 and the second flange 1132 can stably abut against the emulsification film 2, thereby further preventing the deformation and collapse of the emulsification film 2.

[0035] Referring to Figure 4In another embodiment, the first fitting cavity 1142 is provided with a first groove 1144 extending along the radial direction of the base end 114 and cutting each first flange 1143 into two segments. The second fitting cavity 1131 is provided with a second groove 1133 extending along the radial direction of the cover end 113 and cutting each second flange 1132 into two segments, so as to form more emulsification flow spaces. When the liquid raw material flows into the base end 114 and the cover end 113 from the flow channel 111, the liquid raw material can be dispersed between each first flange 1143, between each second flange 1132, and in the first groove 1144 and the second groove 1133, and then uniformly pass through the emulsification film 2, so as to effectively improve the emulsification rate and the uniformity of emulsification mixing.

[0036] The communication between the base end 114, the cover end 113 and the flow channel 111 can be that the middle part of the base end 114 is provided with a first hole 1145 in communication with the flow channel 111, and the middle part of the cover end 113 is provided with a second hole 1134 in communication with the flow channel 111.

[0037] After the connection of each circulation device 1, a valve 12 is arranged between the two operation interfaces 112, so as to effectively control the emulsification communication and block of the flow channel 111 according to the need, and quickly realize multiple-stage emulsification. The operation interface 112 can be a luer interface.

[0038] Any combination of the technical features of the above-described embodiments can be made. In order to make the description simple, all possible combinations of the technical features in the above-described embodiments are not described, however, as long as the combination of the technical features does not exist contradictory, it should be considered that it is within the scope of the present disclosure.

[0039] The above-described embodiments only express several embodiments of the present application, and the description is more specific and detailed, but it should not be understood as a limitation on the scope of the patent. It should be noted that for ordinary skilled in the art, without departing from the concept of the present application, a number of modifications, substitutions and improvements can be made, which should be covered within the scope of protection of the present application. Therefore, the scope of protection of the present application should be subject to the claims.

Claims

1. A compact multi-stage emulsification device, characterized by, The application relates to a circulating device and an emulsification membrane. The circulating device comprises at least three circulating devices and at least two emulsification membranes, the circulating device comprises a circulating body and a valve, the circulating body is provided with a flow channel, an operation interface, a cover end and a base end, opposite ends of the flow channel are communicated with the cover end and the base end respectively, the valve and the operation interface are located between the cover end and the base end, and the valve and the operation interface are communicated with the flow channel, the valve can control the opening and closing of the flow channel, the operation interface can be externally connected with an injection device, the cover end of one of the circulating devices can be connected with the base end of another of the circulating devices to form a cavity, a plurality of micropores are arranged through the emulsification membrane, the emulsification membrane is arranged in the cavity, and raw materials in the flow channel of one of the circulating devices can flow into the flow channel of another of the circulating devices through the micropores of the emulsification membrane. The base end is concave to form a containing cavity, and the cover end is inserted into the containing cavity. The inner side bottom wall of the containing cavity is concave to form a first matching cavity, the end face of the cover end is concave to form a second matching cavity, the first matching cavity is communicated with the second matching cavity to form the cavity, and the emulsification membrane is abutted with the inner side bottom wall of the containing cavity and the end face of the cover end respectively. The first matching cavity is provided with a first flange, the second matching cavity is provided with a second flange, and the first flange and the second flange are abutted with the two side faces of the emulsification membrane respectively. The base end, the cover end and the emulsification membrane are circular, the first flange and the second flange are circular and are provided with a plurality of circular ridges, the first flanges are spaced along the radial direction of the base end, and the second flanges are spaced along the radial direction of the cover end. The first matching cavity is provided with a first groove body, the first groove body extends along the radial direction of the base end, and each first flange is cut into two segments, the second matching cavity is provided with a second groove body, the second groove body extends along the radial direction of the cover end, and each second flange is cut into two segments. The circulating body is arc-shaped, and the connecting of the circulating devices is annular; the pore diameter of each emulsification membrane gradually decreases in the clockwise direction or the counterclockwise direction.

2. The compact multi-stage emulsification device according to claim 1, wherein The valve comprises a valve body and a valve rod, the valve body is hollow, and the valve body is communicated with the flow channel; the valve rod is slidably or threadedly connected with the valve body, and the valve rod can be extended into the flow channel to block the flow channel or withdrawn from the flow channel to make the flow channel flow.

3. The compact multi-stage emulsification device of claim 1, wherein, The position of the first flange is opposite to the position of the second flange.

4. The compact multistage emulsification device according to any one of claims 1 to 3, characterized in that The middle part of the base end is provided with a first hole communicated with the flow channel, the middle part of the cover end is provided with a second hole communicated with the flow channel; and / or the two operation interfaces have one valve after the connecting of the circulating devices.

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