A medical specimen fixing device and an integrated micro-imaging system

Abstract

The application discloses a medical specimen fixing device, which comprises a storage bin, a sample box, a specimen fixing plate and a cover glass. The lower end of the sample box is matched with the storage bin, so that liquid can be in the cavity and the liquid storage cavity at the same time. The upper end of the sample box is provided with a groove. The specimen fixing plate is accommodated in the groove. The cover glass is arranged on the specimen fixing plate and matched with the specimen fixing plate to fix the specimen. The application further discloses an integrated micro-imaging system.

Description

Technical Field

[0001] This invention relates to the field of medical testing technology, and in particular to a medical specimen fixation device and an integrated microscopic imaging system. Background Technology

[0002] In recent years, the incidence of malignant diseases such as gastrointestinal cancer and pancreatic cancer has shown a significant upward trend. In the current clinical diagnosis, in order to clarify the nature of the lesion, clinicians need to obtain the patient's lesion tissue through surgical biopsy and combine it with pathological examination to obtain the final diagnosis. However, the process of fixing, observing, dehydrating, sectioning and HE staining of the puncture specimen is complicated and generally takes several days. The patient's psychological pressure is extremely high during this waiting process, and the accuracy of the puncture during the operation cannot be guaranteed. If cancerous tissue is not obtained in the first operation, it may be necessary to perform another operation to obtain a sample for confirmation. Patient compliance and acceptance are low. Through in-depth communication and collaboration with experts from the Department of Gastroenterology and Department of Pathology of the hospital, the first intraoperative bedside monitoring instrument was developed. It can realize label-free real-time microscopic imaging, thereby enabling real-time dynamic observation of the pathological structure and biochemical information of puncture specimen tissue cells. It can observe puncture tissue at the cellular level, with a lateral optical resolution of 1.5μm and an imaging depth of more than 250μm. It can be applied to the imaging diagnosis of malignant cancer diseases, providing favorable evidence for the determination of the nature of the lesion. This method can obtain diagnostic results at the bedside and can quickly obtain multiple samples during the operation when cancer cells are not obtained by puncture, which is convenient and fast.

[0003] In actual testing, the size of the puncture specimen is determined by the diameter of the biopsy needle, usually around 1 mm. Traditional grooved slides have a fixed groove depth. After adding formalin solution and covering with a coverslip, there is a lack of restraint on smaller specimens, which are prone to movement during observation, making it impossible to obtain clear and stable imaging of the specimen tissue. For larger specimens, compression can easily cause irregular deformation of the tissue, resulting in distortion and aberration of the image under confocal imaging. Furthermore, it can easily damage the specimen, thus affecting the pathological section examination results. The obtained confocal image does not correspond to the HE staining image, failing to achieve the verification effect. Summary of the Invention

[0004] This invention aims to overcome the shortcomings of existing technologies, and adopts the following technical solution:

[0005] On one hand, the present invention provides a medical specimen fixation device. This medical specimen fixation device includes: a storage compartment, a sample box, a specimen fixation plate, and a coverslip;

[0006] The storage compartment is equipped with a liquid storage chamber for storing liquid;

[0007] The lower end of the sample box is provided with a cavity, and the lower end of the sample box cooperates with the storage chamber to allow liquid to be in the cavity and the liquid storage chamber at the same time. The upper end of the sample box is provided with a groove, and the groove is provided with a liquid inlet hole that communicates with the cavity.

[0008] The specimen fixing plate is housed within the groove and is used to place the specimen.

[0009] The cover glass is placed on the specimen fixing plate and works with the specimen fixing plate to fix the specimen.

[0010] In some embodiments, there is a small gap between the specimen fixing plate and the inner wall of the groove, and the specimen fixing plate and the inner wall of the groove are in clearance fit.

[0011] In some embodiments, the upper end of the sample box is provided with an injection hole and an exhaust hole, the injection hole being sealed by a rubber stopper and the exhaust hole being sealed by an exhaust stopper.

[0012] In some embodiments, the specimen fixing plate and the groove are guided and positioned vertically by a guide positioning pin, which is fixedly disposed on the groove.

[0013] In some embodiments, the upper section of the inner wall of the storage compartment is larger than the lower section.

[0014] In some embodiments, the sample box is housed within the liquid storage chamber of the storage compartment.

[0015] In some embodiments, the height of the sample box is less than or equal to the depth of the storage cavity.

[0016] In some embodiments, the sample box is clearance-fitted with the inner wall of the storage compartment.

[0017] In some embodiments, the lower end of the storage compartment is provided with a drain hole, and a drain plug is used to cooperate with the drain hole.

[0018] On the other hand, the present invention also provides an integrated microscopic imaging system, which includes: a scanning head, a two-dimensional motion platform, and a medical specimen fixation device as described above.

[0019] The medical specimen fixation device is mounted on the two-dimensional motion platform;

[0020] The scanning head is positioned above the medical specimen fixation device and can scan the specimen on the medical specimen fixation device.

[0021] Technical effects of the present invention: The medical specimen fixation device and integrated microscopic imaging system disclosed in this invention fix the medical specimen by means of the cooperation of the storage chamber, sample box, specimen fixation plate and coverslip. The specimen fixation plate and coverslip are used to fix the specimen, and a solution cavity is formed between the storage chamber and the sample box. The specimen fixation plate set in the groove of the sample box is gently pressed against the coverslip by the buoyancy of the solution, so as to fix the specimen and prevent it from moving and deforming due to excessive pressure. Attached Figure Description

[0022] To more clearly illustrate the technical solutions in the embodiments of this application, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0023] Figure 1 This is a schematic diagram of a medical specimen fixation device according to an embodiment of the present invention;

[0024] Figure 2 This is a cross-sectional structural diagram of a medical specimen fixation device according to an embodiment of the present invention;

[0025] Figure 3 This is a flowchart illustrating an integrated microscopic imaging system according to an embodiment of the present invention.

[0026] In the picture:

[0027] 1. Scanning head; 2. Specimen fixation device; 3. Two-dimensional motion platform; 4. Storage compartment; 5. Specimen fixation plate;

[0028] 6. Cover glass slide; 7. Sample box; 8. Rubber stopper; 9. Vent plug; 10. Slide holder; 11. Guide positioning pin;

[0029] 12. Drain plug; 13. Solution; 14. Specimen; 15. Groove; 16. Liquid storage chamber; 17. Cavity;

[0030] Integrated microscopic imaging system 100. Detailed Implementation

[0031] To make the objectives, technical solutions, and advantages of this invention clearer, the invention will be further described in detail below with reference to the accompanying drawings and specific embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and do not constitute a limitation thereof.

[0032] In the following description, specific details such as particular system architectures and techniques are set forth for illustrative purposes and not for limitation, in order to provide a thorough understanding of the embodiments of this application. However, those skilled in the art will understand that this application may also be implemented in other embodiments without these specific details. In other instances, detailed descriptions of well-known systems, apparatuses, circuits, and methods have been omitted so as not to obscure the description of this application with unnecessary detail.

[0033] It should be understood that, when used in this application specification and the appended claims, the term "comprising" indicates the presence of the described features, integrals, steps, operations, elements and / or components, but does not exclude the presence or addition of one or more other features, integrals, steps, operations, elements, components and / or a collection thereof.

[0034] It should also be understood that the term “and / or” as used in this application specification and the appended claims means any combination of one or more of the associated listed items and all possible combinations, and includes such combinations.

[0035] As used in this application specification and the appended claims, the term "if" may be interpreted, depending on the context, as "when," "once," "in response to determination," or "in response to detection." Similarly, the phrase "if determined" or "if detected [the described condition or event]" may be interpreted, depending on the context, as meaning "once determined," "in response to determination," "once detected [the described condition or event]," or "in response to detection [the described condition or event]."

[0036] Furthermore, in the description of this application and the appended claims, the terms "first," "second," "third," etc., are used only to distinguish descriptions and should not be construed as indicating or implying relative importance.

[0037] References to "one embodiment" or "some embodiments" as described in this specification mean that one or more embodiments of this application include a specific feature, structure, or characteristic described in connection with that embodiment. Therefore, the phrases "in one embodiment," "in some embodiments," "in other embodiments," "in still other embodiments," etc., appearing in different parts of this specification do not necessarily refer to the same embodiment, but rather mean "one or more, but not all, embodiments," unless otherwise specifically emphasized. The terms "comprising," "including," "having," and variations thereof mean "including but not limited to," unless otherwise specifically emphasized.

[0038] refer to Figure 1 and Figure 2As shown, an embodiment of the present invention provides a medical specimen fixation device 2. The medical specimen fixation device 2 includes:

[0039] Storage compartment 4, sample box 7, specimen fixation plate 5, and coverslip 6;

[0040] The storage compartment 4 is provided with a liquid storage chamber 16 for storing liquid;

[0041] The lower end of the sample box 7 is provided with a cavity 17. The lower end of the sample box 7 cooperates with the storage chamber 4 to allow liquid to be simultaneously in the cavity 17 and the liquid storage chamber 16. The upper end of the sample box 7 is provided with a groove 15. The groove 15 is provided with a liquid inlet hole that communicates with the cavity 17.

[0042] The specimen fixing plate 5 is housed in the groove 15 and is used to place the specimen 14;

[0043] The cover glass 6 is placed on the specimen fixing plate 5 and cooperates with the specimen fixing plate 5 to fix the specimen 14.

[0044] In this embodiment of the invention, "upper end" and "lower end" are understood in the usual sense, and are determined according to the normal position of the medical specimen fixation device 2 during normal actual use.

[0045] In this embodiment of the invention, "inner" and "outer" are used in a common sense, and are determined according to the normal position of the medical specimen fixation device 2 during normal actual use. In some embodiments, the coverslip 6 is fixed with a slide clip 10, which gently presses against the top of the coverslip 6 to prevent it from moving or falling off. The slide clip 10 is rotatably mounted on the upper end of the sample box 7. Preferably, there can be two or more slide clips 10, which can be flexibly arranged according to the position of the coverslip 6 and the direction to be fixed. For example, they can be arranged at even intervals or concentrated in the required fixed positions.

[0046] In some embodiments, the coverslip 6 can be a standard 0.17mm thick coverslip 6. It is understood that, according to the scheme of this embodiment, there are no special requirements for the size and thickness of the coverslip, and it can be adapted to different coverslip sizes.

[0047] In some embodiments, there is a small gap between the specimen fixing plate 5 and the inner wall of the groove 15, and the specimen fixing plate 5 and the inner wall of the groove 15 are in clearance fit.

[0048] In some embodiments, the upper end of the sample box 7 is provided with an injection hole and an exhaust hole, the injection hole is sealed by a rubber stopper 8, and the exhaust hole is sealed by an exhaust stopper 9.

[0049] In some embodiments, the specimen fixing plate 5 and the groove 15 are guided and positioned vertically by a guide positioning pin 11, which is fixedly disposed on the groove 15.

[0050] Furthermore, the guide positioning pin 11 is fixedly disposed on the bottom end of the groove 15.

[0051] Preferably, there are four guide positioning pins 11, and the specimen fixing plate 5 is provided with mating holes, which can be set around the perimeter of the specimen fixing plate 5 to allow more space for placing the specimen 14. The specimen fixing plate 5 can be made of lightweight acrylic material to facilitate floating in the solution 13. The specimen fixing plate 5 is provided with mating holes, and the specimen fixing plate 5 is constrained by the four guide positioning pins 11 when moving up and down. As the solution 13 continues to seep in, the buoyancy gradually increases. When the buoyancy exceeds the weight of the specimen fixing plate 5, it slowly pushes the specimen fixing plate 5 upward along the four guide positioning pins 11. In this way, the specimen 14 also moves upward slowly with the fixing plate.

[0052] It is understood that there may be two or more guide positioning pins 11. The solution 13 set in the storage chamber 4 can communicate with the groove 15 on the sample box 7. Since the specimen fixing plate 5 is set in the groove 15 of the sample box 7, it cooperates with the cover glass 6 under the buoyancy of the solution 13 to fix the specimen 14 set on the specimen fixing plate.

[0053] In this process, the specimen is first constrained by the force of the solution through the sample fixation plate and coverslip, preventing deformation. The specimen does not move during observation, allowing for clear and stable imaging. Even large specimens are not easily deformed by compression, ensuring that the images obtained under confocal imaging are not distorted or warped. Furthermore, the specimen does not need to be removed from the solution during testing, eliminating the risk of damage or contamination and thus not affecting the pathological section examination results. The obtained confocal images correspond to the HE staining images, achieving the desired verification effect. Even if the solution is corrosive, this procedure also protects medical personnel because there is no direct contact with the solution.

[0054] In some embodiments, to facilitate cross-validation with subsequent pathological section examination and analysis, the specimen 14 must not be damaged or contaminated during imaging observation. An ultrasound coupling agent can be applied between the scanning head 1 of the integrated microscopic imaging system 100 and the coverslip 6. Furthermore, the specimen 14 is stored entirely in solution 13 within the medical specimen fixation device 2, wherein solution 13 is medical formalin fixative. The medical formalin fixative can be a 10% neutral formalin solution.

[0055] In some embodiments, the upper section of the inner wall of the storage chamber 4 is larger than the lower section. The purpose of enlarging the upper section of the inner wall of the storage chamber 4 is to temporarily retain excess solution 13 when too much solution 13 is injected, preventing overflow and contamination. The excess solution 13 can then be removed using a pipette. This larger upper section size can be achieved by thinning the inner wall of the storage chamber 4, making the upper section larger than the lower section. The upper section size can be gradually reduced or reduced by a fixed amount.

[0056] In some embodiments, the sample box 7 is housed within the liquid storage chamber 16 of the storage compartment 4.

[0057] In some embodiments, the height of the sample box 7 is less than or equal to the depth of the storage cavity.

[0058] In some embodiments, the sample box 7 is clearance-fitted with the inner wall of the storage compartment 4. This allows the sample box 7 to move vertically relative to the inner wall of the storage compartment 4. Preferably, the outer wall of the sample box 7 is clearance-fitted with the inner wall of the storage compartment 4.

[0059] As can be seen from the embodiments of the present invention, the sample box 7 and the storage chamber 4 are separable, which makes it more convenient to clean them separately when cleaning is required.

[0060] In some embodiments, the lower end of the storage chamber 4 is provided with a drain hole, which is engaged with a drain plug 12. When it is necessary to drain the solution 13, the drain plug 12 can be opened; when not needed, the drain plug 12 can be tightly engaged with the drain hole to prevent the solution 13 from flowing out.

[0061] refer to Figure 3 As shown, this embodiment of the invention also provides an integrated microscopic imaging system 100, which includes: a scanning head 1, a two-dimensional motion platform 3, and a medical specimen fixation device 2 as described above.

[0062] The medical specimen fixation device 2 is mounted on the two-dimensional motion platform 3;

[0063] The scanning head 1 is positioned above the medical specimen fixation device 2 and can scan the specimen 14 on the medical specimen fixation device 2.

[0064] Technical effects of the present invention: The medical specimen fixation device and integrated microscopic imaging system disclosed in this invention fix the medical specimen by means of the cooperation of the storage chamber, sample box, specimen fixation plate and coverslip. The specimen fixation plate and coverslip are used to fix the specimen, and a solution cavity is formed between the storage chamber and the sample box. The specimen fixation plate set in the groove of the sample box is gently pressed against the coverslip by the buoyancy of the solution, so as to fix the specimen and prevent it from moving and deforming due to excessive pressure.

[0065] The embodiments of the present invention improve the grooved glass slides with fixed groove depth by redesigning them. While meeting the observation requirements of the confocal microscopy imaging system, the specimens are preserved in formalin fixative throughout the process. The specimens will not produce irregular deformation or move, and can be compared with pathological test results.

[0066] This patent, while ensuring stable scanning imaging of puncture specimens, solves the problem that traditional grooved glass slides cannot adapt to specimens of different sizes through the aforementioned device. It is suitable for microscope systems to observe the pathological structure and biochemical information of tissue cells in puncture specimens in real time, without damage, and with accuracy, providing timely and favorable evidence for judging the nature of the patient's lesion, assisting doctors in diagnosis, and improving the efficiency of clinical diagnosis.

[0067] The present invention will now be described in detail with reference to the embodiments shown in the accompanying drawings. However, these embodiments do not limit the present invention, and any structural, methodological, or functional modifications made by those skilled in the art based on these embodiments are included within the scope of protection of the present invention.

[0068] Example 1

[0069] like Figure 2 The diagram illustrates the operation of a medical specimen fixation device 2 according to a specific embodiment of the present invention:

[0070] The medical specimen fixation device 2 includes a storage chamber 4, a specimen fixation plate 5, a coverslip 6 (a standard 0.17mm thick coverslip 6), and a sample box 7. The specimen 14 is a biopsy specimen obtained during surgery. It is placed on the specimen fixation plate 5, covered with the coverslip 6, and gently held in place by the slide clip 10 to prevent movement or dislodgement. Then, the rubber stopper 8 and the vent plug 9 are removed, and 10% neutral formalin solution 13 is injected into the cavity formed by the storage chamber 4 and the sample box 7. The solution 13 is slowly injected into the cavity, and air is expelled through the vent plug 9. When the solution 13 rises to the same height as the specimen fixation plate 5, the solution 13 is released. The solution 13 seeps into the groove 15 containing the specimen 14 through the inlet hole below the specimen fixation plate 5. The specimen fixation plate 5 is made of lightweight acrylic material with holes at its four tops. It is restrained by four guide pins 11 as it moves up and down. As the solution 13 continuously seeps in, the buoyancy gradually increases, exceeding the weight of the specimen fixation plate 5 itself. This slowly pushes the specimen fixation plate 5 upwards along the four guide pins 11, and the punctured tissue specimen 14 also slowly moves upwards with the specimen fixation plate 5. In the design, the height of the interior of the specimen 14 chamber is slightly higher than the horizontal height of the coverslip 6. Therefore, as the solution 13 is continuously injected, the punctured tissue specimen 14 is eventually gently pressed against the lower surface of the coverslip 6 by the specimen fixation plate 5, cleverly fixing the specimen 14 and preventing it from moving or being excessively deformed. Simultaneously, due to the tiny gap between the specimen fixation plate 5 and the inner wall of the groove 15, the solution 13 will permeate the punctured tissue specimen 14, perfectly meeting the requirements of confocal microscopy imaging. The upper section of the inner wall of the storage chamber 4 is enlarged to temporarily retain excess 10% neutral formalin solution 13, preventing it from overflowing and contaminating the two-dimensional motion platform 3. Excess solution 13 can then be removed using a pipette. The bottom of the storage chamber 4 has a drain hole and a drain plug 12. After testing, remove the drain plug 12, pour out the 10% neutral formalin solution 13, and repeatedly rinse the medical specimen fixation device 2 with deionized water injected through the water inlet of the rubber stopper 8. This also allows for the separation of the sample box 7 from the storage chamber 4 for separate cleaning. The operation is simple and the device is reusable.

[0071] Example 2

[0072] like Figure 3 The diagram illustrates the operation of an integrated microscopic imaging system 100 according to a specific embodiment of the present invention:

[0073] The integrated microscopic imaging system 100 is specifically composed of a scanning head 1, a medical specimen fixation device 2, and a two-dimensional motion platform 3.

[0074] The medical specimen fixation device 2 is mounted on a precision two-dimensional motion platform 3, forming an integrated microscopic imaging system 100 suitable for bedside point-of-care diagnosis with the liftable confocal scanning head 1. It uses a combination of a two-dimensional stage knob and motor drive to detect and rapidly scan different parts of the specimen tissue, obtaining confocal images of the tissue. During imaging observation, the specimen 14 must not be damaged or contaminated. An ultrasound coupling agent can be applied between the scanning head 1 of the integrated microscopic imaging system 100 and the coverslip 6.

[0075] The steps of the methods or algorithms described in conjunction with the embodiments disclosed herein can be implemented in hardware, a software module executed by a processor, or a combination of both. The software module can be located in random access memory (RAM), main memory, read-only memory (ROM), electrically programmable ROM, electrically erasable programmable ROM, registers, hard disk, removable disk, CD-ROM, or any other form of storage medium known in the art.

[0076] In the description of this invention, it should be understood that the symbols such as parameters, variables, and program names mentioned in the embodiments of this invention can be replaced with any other code name that will not cause confusion.

[0077] In the description of this invention, it should be understood that the terms "center," "longitudinal," "lateral," "length," "width," "thickness," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "clockwise," "counterclockwise," "axial," "radial," and "circumferential" indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are used only for the convenience of describing this invention and simplifying the description, and are not intended to indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this invention.

[0078] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Thus, a feature defined with "first" or "second" may explicitly or implicitly include at least one of that feature.

[0079] In this invention, unless otherwise explicitly specified and limited, the terms "installation," "connection," "linking," and "fixing," etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components, unless otherwise explicitly limited. Those skilled in the art can understand the specific meaning of the above terms in this invention according to the specific circumstances.

[0080] In this invention, unless otherwise explicitly specified and limited, "above" or "below" the second feature can mean that the first feature is in direct contact with the second feature, or that the first feature is in indirect contact with the second feature through an intermediate medium. Furthermore, "above," "over," and "on top" of the second feature can mean that the first feature is directly above or diagonally above the second feature, or simply that the first feature is at a higher horizontal level than the second feature. "Below," "below," and "under" the second feature can mean that the first feature is directly below or diagonally below the second feature, or simply that the first feature is at a lower horizontal level than the second feature.

[0081] In the description of this specification, the references to terms such as "one embodiment," "some embodiments," "example," "specific example," or "some examples," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the present invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples. Moreover, without contradiction, those skilled in the art can combine and integrate the different embodiments or examples described in this specification, as well as the features of different embodiments or examples.

[0082] Although embodiments of the present invention have been shown and described above, it is understood that the above embodiments are exemplary and should not be construed as limiting the present invention. Those skilled in the art can make changes, modifications, substitutions and variations to the above embodiments within the scope of the present invention.

[0083] The specific embodiments of the present invention described above do not constitute a limitation on the scope of protection of the present invention. Any other corresponding changes and modifications made in accordance with the technical concept of the present invention should be included within the scope of protection of the claims of the present invention.

Claims

1. A medical specimen fixation device, characterized by, The application relates to a medical specimen fixing device. The device comprises a storage bin provided with a liquid storage cavity for storing liquid; A sample box is provided with a cavity at the lower end, and the lower end of the sample box is matched with the storage bin to make the liquid in the cavity and the liquid storage cavity at the same time; a groove is arranged at the upper end of the sample box, and the groove is provided with a liquid inlet hole communicated with the cavity; A specimen fixing plate is arranged in the groove and used for placing a specimen; a cover glass is arranged on the specimen fixing plate and used for fixing the specimen. The buoyancy of the solution infiltrated into the liquid storage cavity is greater than the gravity of the specimen fixing plate.

2. The medical specimen fixation device of claim 1, wherein A small gap exists between the specimen fixing plate and the inner wall of the groove, and the specimen fixing plate and the inner wall of the groove are matched in a gap mode.

3. The medical specimen fixation device of claim 1, wherein, The upper end of the sample box is respectively provided with a liquid injection hole and an exhaust hole, the liquid injection hole is sealed by a rubber plug, and the exhaust hole is sealed by an exhaust plug.

4. The medical specimen fixation device of claim 1, wherein, The specimen fixing plate and the groove are guided and positioned in the up-down direction by a guide positioning pin fixed on the groove.

5. The medical specimen fixation device of claim 1, wherein, The size of the upper section of the inner wall of the storage bin is greater than that of the lower section.

6. The medical specimen fixation device of claim 1, wherein, The sample box is arranged in the liquid storage cavity of the storage bin.

7. A medical specimen fixation device according to claim 6, wherein The height of the sample box is less than or equal to the depth of the storage cavity.

8. The medical specimen fixation device of claim 6, wherein, The sample box and the inner wall of the storage bin are matched in a gap mode.

9. The medical specimen fixation device of claim 1, wherein, The lower end of the storage bin is provided with a liquid discharge hole, and a drain plug is matched with the liquid discharge hole.

10. An integrated microscopy system, comprising: The device comprises a scanning head, a two-dimensional motion platform and the medical specimen fixing device according to any one of claims 1-9. The medical specimen fixing device is arranged on the two-dimensional motion platform. The scanning head is arranged above the medical specimen fixing device and can scan the specimen on the medical specimen fixing device.

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