Medical syringe cover and package thereof

Abstract

Provided is a medical injector sheath and a package thereof, which can ensure sufficient operation stroke, prevent rattling, or facilitate extraction when a small-volume syringe of a luer lock type is transported while being held in a nest plate. The medical injector sheath includes a cylindrical barrel portion for housing an internal fluid inside, a cylindrical injection nozzle portion formed at one end of the barrel portion, and a flange portion protruding outward in a radial direction provided at an opening portion at the other end of the barrel portion. The barrel portion includes an intermediate barrel portion having an outer diameter smaller than an outer diameter of the injection nozzle portion, and a large-diameter barrel portion having an outer diameter identical to the outer diameter of the injection nozzle portion and formed between the flange portion and the intermediate barrel portion.

Description

TECHNICAL FIELD

[0001] The present application relates to a syringe jacket constituting a medical syringe and a package for transporting the syringe jacket. BACKGROUND

[0002] Generally, a medical syringe is composed of a syringe jacket having a syringe needle attached to the front end and a syringe plunger inserted into an opening at the other end of the syringe jacket to move a piston in the axial direction. A flange is provided to the opening at the other end of the syringe jacket to project to the outside in the radial direction. As a form of the front end of the syringe jacket to which the syringe needle is attached, there are a luer slip joint type, a luer lock joint type, and the like. From the viewpoint of preventing medical accidents, the configuration for fixing the syringe needle is determined by ISO standards. The luer lock joint type has a locking function at the front end of the syringe, and is a form suitable for cases where it is desired to firmly connect the syringe needle.

[0003] The outer diameter of the front end of the syringe jacket, i.e., the luer lock joint portion, is determined in accordance with ISO standards. In a small-volume syringe, in order to ensure a prescribed stroke for use convenience at the time of injection, it is necessary to reduce the inner diameter of the barrel portion filled with an internal solution. In the case of manufacturing a syringe jacket in which the outer diameter of the barrel portion is equal to the outer diameter of the luer lock joint portion by injection molding of a thermoplastic resin, molding defects occur in the barrel portion of the jacket having a large wall thickness. Therefore, as described in Patent Document 1, a syringe barrel is proposed in which the outer diameter of the jacket barrel portion is made smaller than the outer diameter of the luer lock joint portion to ensure an adequate stroke. In Patent Document 2, a configuration of a syringe jacket is disclosed in which a large-diameter portion having a larger inner diameter than the inner diameter of the intermediate portion is provided at the distal end side.

[0004] Furthermore, in order to simplify the management of medicines, prevent infection, prevent mistakes at the time of adjustment, rapid injection, and the like, a pre-filled syringe in which an accurate injection amount is filled in advance is used. Generally, the assembled components of the syringe, such as the syringe jacket, the piston, and the plunger, are transported to a pharmaceutical company, filled with an internal solution, and assembled into a syringe. Therefore, it is necessary to transport the syringe while maintaining a sterilized state, and as shown in Patent Documents 3 and 4, a container composed of a nest plate and a box is proposed.

[0005] Patent Document 1: Japanese Patent Application Publication No. 2013-116289

[0006] Patent Document 2: Japanese Utility Model Registration No. 1468280

[0007] Patent Document 3: International Patent Publication No. WO2014 / 109011A1

[0008] Patent Document 4: Japanese Patent No. 6040025 SUMMARY

[0009] Technical problem to be solved by the invention

[0010] If the syringe outer case disclosed in Patent Documents 1 and 2 is housed in the nest plate shown in Patent Documents 3 and 4 for transportation to a pharmaceutical company or the like that assembles the syringe together with other components such as a piston, a plunger rod, and the like as a pre-filled syringe, shaking at the nest plate occurs at the time of carrying. This shaking becomes a cause of damage of the components by contact with each other during the carrying, and there is also a possibility of hindrance at the time of extraction from the nest plate.

[0011] Therefore, it is sought to provide a syringe outer case and a package thereof that can prevent undesired contact of components with each other at the time of carrying using a nest plate and at the time of extraction from the nest plate, and that can achieve an easy extraction operation.

[0012] Technical solution for solving the technical problem

[0013] (1) The medical syringe outer case of the present invention includes a cylindrical barrel portion for housing an internal liquid in the inside, a cylindrical nozzle portion formed at one end of the barrel portion, and a flange portion protruding to the radial direction outside provided at the opening portion of the other end of the barrel portion.

[0014] The barrel portion includes an intermediate barrel portion having an outer diameter smaller than that of the nozzle portion, and a large-diameter barrel portion formed between the flange portion and the intermediate barrel portion and having the same outer diameter as that of the nozzle portion.

[0015] At the time of fitting the medical syringe outer case configured in this way into the cylindrical component of the nest plate from above with the nozzle portion downward, the nozzle portion having an outer diameter slightly smaller than the inner diameter of the cylindrical component of the nest plate is passed through the cylindrical component, and the intermediate barrel portion and the large-diameter barrel portion are sequentially entered into the cylindrical component, and the syringe outer case is housed in the cylindrical component by the contact of the upper end of the cylindrical component with the flange portion.

[0016] By providing the large-diameter barrel portion having the same outer diameter as that of the nozzle portion, the shaking of the syringe outer case in the cylindrical component at the time of housing in the nest plate for transportation can be suppressed. Also, the center axis of the cylindrical component coincides with the center axis of the syringe outer case, and misalignment is difficult to occur. In addition, the extraction of the syringe outer case directly from the cylindrical component becomes easy.

[0017] (2) In the present invention, on the basis of the medical syringe outer case of (1), the axial length of the large-diameter barrel portion is set to be 1 / 3 or less of the axial length of the barrel portion.

[0018] Thus, by making the large-outer-diameter barrel portion an appropriate length, the swaying of the syringe outer case within the cylindrical member, misalignment, and easy extraction of the syringe outer case from the cylindrical member can be more effectively suppressed. On the other hand, if the large-outer-diameter barrel portion is too long, the distance from the opening of the flange portion of the syringe outer case to the prescribed position of the piston (the prescribed content amount filling position) becomes long when the piston is vacuum-tipped. Therefore, the axial length of the large-outer-diameter barrel portion is preferably set to be 1 / 3 or less of the axial length of the barrel portion.

[0019] (3) The medical syringe outer case packaging body of the present application holds at least one syringe outer case in a nest plate having at least a flat plate-shaped member provided with an opening, and a cylindrical member formed with one end joined to the opening and the other end formed as a protruding end protruding upward.

[0020] The syringe outer case held in the nest plate has a cylindrical barrel portion for housing an internal use liquid inside, a cylindrical nozzle portion formed at one end of the barrel portion, and a flange portion provided at the opening of the other end of the barrel portion and protruding outward in the radial direction, the barrel portion including an intermediate barrel portion having an outer diameter smaller than that of the nozzle portion, and a large-outer-diameter barrel portion formed between the flange portion and the intermediate barrel portion and having an outer diameter the same as that of the nozzle portion.

[0021] The inner diameter of the cylindrical member is set to be larger than the outer diameter of the large-outer-diameter barrel portion and smaller than the outer diameter of the flange portion, the flange portion abuts against the protruding end of the cylindrical member, and at least a portion of the barrel portion is held within the cylindrical member.

[0022] In the medical syringe outer case packaging body configured in this way, when the cylindrical member of the nest plate is loaded from above with the nozzle portion downward, the nozzle portion having an outer diameter slightly smaller than the inner diameter of the cylindrical member of the nest plate passes through the cylindrical member, enters the cylindrical member in the order of the intermediate barrel portion and the large-outer-diameter barrel portion, and the syringe outer case is housed in the cylindrical member by the flange portion contacting the upper end of the cylindrical member.

[0023] By providing the syringe outer case with the large-outer-diameter barrel portion having the same outer diameter as that of the nozzle portion, the swaying of the syringe outer case within the cylindrical member can be suppressed when such a packaging body is transported. Also, the center axis of the cylindrical member coincides with the center axis of the syringe outer case, making misalignment difficult. In addition, the syringe outer case can be easily extracted directly from the cylindrical member.

[0024] In the present application of (4), the axial length of the large-outer-diameter barrel portion is set to be 1 / 3 or less of the axial length of the barrel portion, based on the medical syringe outer case packaging body of (3).

[0025] Thus, by making the large-outer-diameter barrel portion an appropriate length, the swaying of the syringe outer sleeve within the cylindrical member, misalignment, and extraction of the syringe outer sleeve from the cylindrical member can be more effectively suppressed. On the other hand, if the large-outer-diameter barrel portion is too long, the distance from the opening of the flange portion of the syringe outer sleeve to the prescribed position of the piston (the prescribed content amount filling position) becomes long when the piston is vacuum-tapped. Therefore, the axial length of the large-outer-diameter barrel portion is preferably set to be 1 / 3 or less of the axial length of the barrel portion.

[0026] Effects of the Invention

[0027] The medical syringe outer sleeve and the package thereof according to the present application can ensure sufficient operation stroke in a small-volume syringe of the Luer lock type, prevent swaying when transported while held in a nest plate, and make the extraction action easy. BRIEF DESCRIPTION OF DRAWINGS

[0028] Figure 1 (A) is a perspective view showing one configuration example of a medical syringe in which a syringe outer sleeve of one embodiment of the present application is filled with an internal solution and assembled with a piston, a plunger rod, and a finger rest, and (B) is a perspective view of the medical syringe shown in (A) viewed from another angle.

[0029] Figure 2 (A) is an axial sectional view of a syringe outer sleeve of one embodiment of the present application, and (B) is a side view viewed from an arrow B in (A).

[0030] Figure 3 is a perspective view showing the outline configuration of a container used for a package of a medical syringe outer sleeve of one embodiment of the present application.

[0031] Figure 4 is a partial sectional view of a package of a medical syringe outer sleeve of one embodiment of the present application.

[0032] Figure 5 is a perspective view showing the appearance of a container used for a package of a medical syringe outer sleeve of one embodiment of the present application.

[0033] Figure 6 is a view showing one example of use of the tip end of an arm for operating a syringe outer sleeve in a package of a medical syringe outer sleeve of one embodiment of the present application. DETAILED DESCRIPTION

[0034] Hereinafter, the configuration of a medical syringe outer sleeve of one embodiment of the present application will be described with reference to the drawings. Figure 1This is a perspective view illustrating an example of the configuration of a medical syringe assembled with a piston, plunger, and finger rest, according to one embodiment of the present invention, wherein the syringe jacket is filled with an internal fluid. This medical syringe is, for example, a small-capacity pre-filled syringe for ophthalmic use, and is assumed to be a single-use, disposable syringe.

[0035] exist Figure 1 In this assembly, syringe 10 is an assembly of syringe jacket 20, finger support 30, syringe plunger 40, and piston 50. Internal liquid 60 is housed in the hollow portion of the cylindrical syringe jacket 20. The internal liquid 60 is expelled from the front end of the syringe jacket 20 by pressing the piston 50 with the tip of the syringe plunger 40. Figure 1 As shown, the syringe jacket 20 is a transparent cylindrical body, such as a molded glass or polyolefin resin, through which the internal liquid 60, piston 50, and part of the syringe rod 40 inside the hollow part can be seen.

[0036] Figure 2 This is an axial cross-sectional view showing the structure of a syringe jacket 20 according to one embodiment of the present invention. The syringe jacket 20 is a molded article obtained by injection molding of a synthetic resin such as a polyolefin resin, and consists of a cylindrical body 21 for containing internal liquid, an injection nozzle 22 on which an injection needle, for example, is formed at one end of the body 21, and a flange 23 protruding radially outward from an opening at the other end of the body 21. This syringe jacket 20 is used, for example, in very small-capacity syringes such as those for ophthalmic use (0.25 mL).

[0037] exist Figure 2 In (A), the nozzle 22 is a Luer-locking connector type, conforming to ISO 80369-7 standard. The cylindrical nozzle has a tapered surface that gradually tapers towards the front end on its outer periphery. The outer side of this cylindrical nozzle engages with a threaded cylinder with external threads on its inner wall. This construction ensures a tight fit with the injection needle, reliably preventing the installed injection needle from loosening or dislodging from the nozzle during use in medical settings. It should be noted that this syringe jacket 20 is used for mixing intravenous fluids or as a syringe for mixing two medications.

[0038] The nozzle 22 conforms to the international standard ISO 80369-7 for preventing misconnection; therefore, its shape and other features are determined according to the standard. Figure 2 In this case, the axial length C of the threaded cylindrical portion of the injection nozzle 22 is more than 70% of its outer diameter D22. For example... Figure 2 As shown in (B), for the syringe sheath 20, when from Figure 2The flange 23 has a shape in which two circular arcs are connected by a straight line, as viewed in the direction of the arrow B in (A). Also, the inner wall 22N of the nozzle barrel portion inside the nozzle portion 22, the inner wall 21N of the middle barrel portion 21M, and the inner wall 25N of the large-diameter barrel portion 24 are arranged in concentric circles.

[0039] In the case of an extremely small volume syringe for ophthalmic use of 0.25 mL or less, it is necessary to have a prescribed stroke for the purpose of use convenience at the time of injection, and therefore the inner diameter of the barrel portion (middle barrel portion 21M) filled with the internal solution is reduced (the diameter of the inner wall 21N is reduced).

[0040] However, in the case of a general syringe outer sleeve in which the outer diameter of the nozzle portion to the end of the barrel portion (the vicinity of the flange portion) is equal, if the inner diameter of the middle barrel portion is reduced, the wall of the outer sleeve barrel portion becomes thick, and a molding defect called a sink mark is generated. In the present embodiment, since the syringe outer sleeve 20 is an injection-molded product of synthetic resin, in order to prevent a molding defect such as a sink mark due to injection molding, the outer diameter D21 of the middle barrel portion 21M is reduced without making the wall thickness of the middle barrel portion 21M large. Between the flange portion 23 and the middle barrel portion 21M, a large-diameter barrel portion 24 having a larger outer diameter than the middle barrel portion 21M is provided. The wall thickness of this large-diameter barrel portion 24 is set to be equal to the wall thickness of the middle barrel portion 21M, and the inner diameter (the diameter of the inner wall 24N) of the large-diameter barrel portion 24 is set to be large.

[0041] The outer diameter D24 of the large-diameter barrel portion 24 is set to be equal to the outer diameter D22 of the threaded barrel portion of the nozzle portion 22. It is preferable that the outer diameter D21 of the middle barrel portion 21M be 50% or more of the outer diameter D22 of the nozzle portion 22 or the outer diameter D24 of the large-diameter barrel portion 24. Note that the flange portion 23 and the large-diameter barrel portion 24 are connected continuously with a circular arc. The large-diameter barrel portion 24 and the middle barrel portion 21M are connected by a portion having a taper.

[0042] The axial length d of the portion of the large-diameter barrel portion 24 in which the outer diameter D22 of the nozzle portion 22 is equal is determined in consideration of the length of the middle barrel portion 21M required for an extremely small volume syringe, and the length of the middle barrel portion 21M required for vacuum unblocking of the piston. If the axial length d of the portion of the large-diameter barrel portion 24 in which the outer diameter D22 of the nozzle portion 22 is equal is too long, there is a problem in that the distance to the opening to a prescribed position of the piston (a prescribed content amount filling position) becomes long at the time of vacuum unblocking of the piston. Note that the prescribed position of the piston is not set in the portion in which the inner diameter is larger than the inner diameter of the middle barrel portion 21M for receiving the internal solution.

[0043] From such a viewpoint, the axial length d of the portion of the large-diameter barrel portion 24 that is equal in outer diameter to the discharge nozzle portion 22 is set to be in the range of L / 3 ≥ d > 0 in relation to the length L of the barrel portion 21 of the syringe sheath 20.

[0044] In the case where the syringe sheath 20 configured in this manner is transported to a pharmaceutical company or the like, the Figure 3 The medical instrument container 300 shown in FIG. 1 is configured by a nest plate and a box. The container 300 is configured by a nest plate 310, a box 320, and a film 330. The nest plate 310 is provided with a plurality of cylindrical members 312 that project upward from a flat plate member 311. The flat plate member 311 is provided with a plurality of openings, each of which is combined with one end of the cylindrical member 312 and the other end becomes a projecting end that projects upward. The inner diameter of each opening is equal to the inner diameter of each cylindrical member 312, and is disposed so that the centers thereof coincide with each other.

[0045] Each cylindrical member 312 functions as a holder that holds the syringe sheath 20. As shown in FIG. 2, the inner diameter a of the cylindrical member 312 is set to be larger than the outer diameter D24 of the large-diameter barrel portion 24, and the shortest outer diameter b of the flange portion 23 is set to be larger than the inner diameter a of the cylindrical member 312. The flange portion 23 abuts against the projecting end of the cylindrical member 312, and a portion of the barrel portion 21 is held inside the cylindrical member 312. Figure 4

[0046] In this embodiment, if the axial length d of the portion of the large-diameter barrel portion 24 that is equal in outer diameter to the discharge nozzle portion 22 is added to the length of the thickness of the flange portion 23 as Lb, and the axial length of the cylindrical member 312 is added to the length of the thickness of the flat plate member 211 as La, it is preferable that the length Lb be 40% to 60% of the length La. Note that the length La is determined in accordance with the ISO standard.

[0047] As shown in FIG. 3, in the box 320, the nest plate 310 that holds a plurality of syringe sheaths 20 in a plurality of cylindrical members 312 is housed, and is sealed by the gas-impermeable film 330 to configure Figure 3 Figure 5 The medical instrument container 300 shown in FIG. 1 is configured by a nest plate and a box. The container 300 is configured by a nest plate 310, a box 320, and a film 330. The nest plate 310 is provided with a plurality of cylindrical members 312 that project upward from a flat plate member 311. The flat plate member 311 is provided with a plurality of openings, each of which is combined with one end of the cylindrical member 312 and the other end becomes a projecting end that projects upward. The inner diameter of each opening is equal to the inner diameter of each cylindrical member 312, and is disposed so that the centers thereof coincide with each other.

[0048] Note that, in addition to the sealing of the opening portion by the gas-impermeable film described above, as another packaging method, there is

[0049] (1) A method in which, after the box opening portion is sealed by a gas-permeable film, the entire box is reduced-pressure packaged,​​

[0050] (2) a method of sealing the opening portion with a gas-impermeable film from above the gas-permeable film under reduced pressure after sealing the opening portion with the gas-permeable film,

[0051] (3) a packaging method other than the above, which enables packaging and transportation while maintaining the cleanliness inside the case at an appropriate management value

[0052] and the like, any one of the packaging methods or other publicly known packaging methods can be employed in the present embodiment.

[0053] Next, the function of the medical syringe sheath and the packaging body of the present embodiment will be described. The syringe sheath 20 in the shape shown in Figure 2 is manufactured by injection molding of synthetic resin, and is loaded in the order of the injection nozzle portion 22, the intermediate barrel portion 21, and the large-diameter barrel portion 24 from above the tubular member 312 by an automated process, as shown in Figure 6 , with the injection nozzle portion 22 on the lower side and the flange portion 23 supported by the tip 600 of the arm. The flange portion 23 is supported by the protruding end of the tubular member 312, and thus a portion of the syringe sheath 20 is held to the tubular member 312.

[0054] Since the outer diameter D22 of the injection nozzle portion 22 is set to be equal to the outer diameter D24 of the large-diameter barrel portion 24, and the inner diameter a of the tubular member 312 is slightly larger than the outer diameters D22 and D24 of the two portions, the syringe sheath 20 can be prevented from shaking inside the tubular member 312. In a state where the syringe sheath 20 is housed in the container 300 shown in Figure 5 , it is shipped to a pharmaceutical company, and when the pharmaceutical company fills the inner liquid, the container 300 is opened, and the syringe sheath 20 is pulled out by the tip 600 of the arm, as shown in Figure 6

[0055] At this time, since the outer diameter D22 of the injection nozzle portion 22 is equal to the outer diameter D24 of the large-diameter barrel portion 24, the syringe sheath 20 is pulled out in a state where the center axis of the syringe sheath 20 and the center axis of the tubular member 312 are substantially aligned. Thus, the syringe sheath 20 can be directly pulled out of the tubular member 312. Therefore, the pulling-out operation of the syringe sheath 20 is stable, and the syringe sheath 20 can be prevented from colliding with the inner wall of the tubular member 312 or the like.

[0056] ​According to the above-described embodiment, it is possible to provide a medical injector outer case and a package thereof in which sufficient operation stroke can be ensured, in which shaking during transportation while being held by a cylindrical member of a nest plate is prevented or extraction is facilitated, in a small volume injector of a luer lock type. Also, the medical injector outer case and the package thereof according to the embodiment are applicable to a pre-filled injector in which a medical liquid is filled in the injector outer case in advance and assembled.

[0057] BRIEF DESCRIPTION OF DRAWINGS

[0058] 10 injector;

[0059] 20 injector outer case;

[0060] 21 barrel portion;

[0061] 21M middle barrel portion;

[0062] 22 injection nozzle portion;

[0063] 23 flange portion;

[0064] 24 large outer diameter barrel portion;

[0065] 30 finger rest;

[0066] 40 injector core rod;

[0067] 50 piston;

[0068] 60 medical liquid;

[0069] 300 container;

[0070] 310 nest plate;

[0071] 311 flat plate-shaped member;

[0072] 312 cylindrical member;

[0073] 320 box;

[0074] 330 film;

[0075] 600 tip of arm.

Claims

1. A medical syringe sheath comprising a cylindrical barrel portion for housing an internal fluid in the interior thereof, a cylindrical nozzle portion formed at one end of the barrel portion, and a flange portion protruding to the radial direction outside provided at the opening portion of the other end of the barrel portion, characterized in that the barrel portion comprises an intermediate barrel portion having an outer diameter smaller than that of the nozzle portion, and a large-diameter barrel portion having the same outer diameter as that of the nozzle portion and formed between the flange portion and the intermediate barrel portion, the wall thickness of the large-diameter barrel portion is set to be equal to that of the intermediate barrel portion, the inner diameter of the large-diameter barrel portion is set to be larger than that of the intermediate barrel portion, and the nozzle portion is integrally formed with the barrel portion.

2. The medical syringe sheath according to claim 1, characterized in that the axial length of the large-diameter barrel portion is set to be 1 / 3 or less of the axial length of the barrel portion.

3. A medical syringe sheath package in which at least one syringe sheath is held in a nest plate having a flat plate-like member provided with at least one opening, and a cylindrical member formed with one end combined with the opening and the other end formed as a protruding end protruding upward, characterized in that the syringe sheath held in the nest plate comprises a cylindrical barrel portion for housing an internal fluid in the interior thereof, a cylindrical nozzle portion formed at one end of the barrel portion, and a flange portion protruding to the radial direction outside provided at the opening portion of the other end of the barrel portion, the barrel portion comprises an intermediate barrel portion having an outer diameter smaller than that of the nozzle portion, and a large-diameter barrel portion having the same outer diameter as that of the nozzle portion and formed between the flange portion and the intermediate barrel portion, the wall thickness of the large-diameter barrel portion is set to be equal to that of the intermediate barrel portion, the inner diameter of the large-diameter barrel portion is set to be larger than that of the intermediate barrel portion, the nozzle portion is integrally formed with the barrel portion, the inner diameter of the cylindrical member is set to be larger than the outer diameter of the large-diameter barrel portion and smaller than the outer diameter of the flange portion, the flange portion abuts against the protruding end of the cylindrical member, and at least a portion of the barrel portion is held in the cylindrical member.

4. The medical syringe sheath package according to claim 3, characterized in that the axial length of the large-diameter barrel portion is set to be 1 / 3 or less of the axial length of the barrel portion. ​ ​ ​ ​ ​ ​ ​ ​ ​

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