Compact implantable biosensor assembly and bioinformation monitoring device

Abstract

The present invention discloses a compact implantable biosensor component and a biological information monitoring device containing the component, comprising a shell, an implantable sensing electrode, a needle-assisting part and a barrier; the implantable sensing electrode comprises a first wide vertical section, a transverse connecting section and an implanted sensing section, and a lead-out electrode is arranged on the surface of the first wide vertical section; the needle-assisting part comprises a needle seat and an implantation needle; the lower parts of the implanted sensing section and the implantation needle are sealed in a closed space formed by the barrier, the lower part of the shell and the lower part of the needle-assisting part; the transverse connecting section of the implantable sensing electrode is embedded in the shell; the lead-out electrode leaks out of the surface of the shell, and the lead-out electrode is used to connect with a transmitter; or, the lead-out electrode leaks out on the bottom surface of a countersunk hole in the upper part of the shell, and the lead-out electrode is used to connect with the transmitter; the shell is provided with an assembly structure for clamping with the transmitter, and the implantable biosensor component is directly connected to the transmitter circuit board through the lead-out electrode, and the structure is compact.

Description

Technical Field

[0001] The present invention relates to the technical field of biological information monitoring, and in particular to a compact implantable biosensor component and a biological information monitoring device. Background Art

[0002] For the diabetic population, traditional fingertip blood glucose meters have shortcomings such as being invasive, having limited information, and being unable to reflect blood glucose fluctuations and provide warnings. They can no longer meet the needs of some people, especially type 1 diabetes patients who have real-time transmission requirements for blood glucose fluctuations and type 2 diabetes patients who require intensive insulin treatment.

[0003] Due to the need for continuous blood glucose monitoring, the integrated implant component and internal components of the implantable biosensor are required to implant the sensor into the subcutaneous tissue of the human body. Measuring the blood glucose concentration between tissue fluids is a continuous monitoring method that can be used in reality. Its single service life is one to two weeks, which greatly reduces the pain caused by the process of continuous fingertip blood sampling and venous blood sampling. Currently, such implant devices on the market have problems such as complex user operation, long implantation process, and easy mis-triggering of the push device, which leads to reduced user compliance (Patient compliance / Treatmentcompliance, also known as compliance, refers to the patient's behavior of taking treatment according to the doctor's prescription and consistent with the doctor's orders. It is usually called patient "cooperation"; otherwise it is called non-compliance) and experience.

[0004] In the prior art, the transmitter (a device for transmitting monitored biological signals) has a compact structure and volume, which helps to improve the wearing experience. In the current integrated products, the transmitter is in working or silent state when placed inside the transmitter. However, no matter which of the above methods is used, the transmitter and the sensor assembly have been electrically connected. In the smaller size of the transmitter, the battery size is limited, resulting in a small battery capacity. The hardware needs to have extremely low power consumption to meet the shelf life (shelf life, Shelf-life, also known as shelf life, or packaging validity period, it is a guarantee and commitment to the quality and efficacy of the product during the circulation period) requirements.

[0005] In the current integrated products, the transmitter and the implantable sensing electrode are integrated into one unit. After production, they need to be disinfected and sterilized before being implanted into the human body. Disinfection and sterilization require a relatively large packaging box, which takes up a large space and is costly.

[0006] Currently, there is no technical solution in the industry for the separate design of implantable sensing electrodes and transmitter circuit boards. Summary of the invention

[0007] In view of the above, the present invention provides a compact implantable biosensor assembly with a small disinfection and sterilization unit that consumes little or no electricity before implantation into the human body.

[0008] A compact implantable biosensor assembly includes a housing, an implantable sensing electrode, a needle aid, and a barrier;

[0009] The implantable sensing electrode comprises a first wide vertical section, a transverse connecting section and an implantation sensing section, the two sides of the transverse connecting section are respectively connected to the lower end of the first wide vertical section and the upper end of the implantation sensing section, and the surface of the first wide vertical section is provided with a lead-out electrode; the needle-assisting member comprises a needle seat and an implantation needle;

[0010] The implanted sensing section and the lower part of the implantation needle are sealed in a closed space formed by the barrier, the lower part of the housing and the lower part of the needle-assisting member; the transverse connecting section of the implanted sensing electrode is embedded in the housing;

[0011] The lead-out electrode leaks out of the surface of the shell, and the lead-out electrode is used to connect with the emitter; or, the lead-out electrode leaks out of the bottom surface of the upper countersunk hole of the shell, and the lead-out electrode is used to connect with the emitter;

[0012] The housing is provided with an assembly structure for snapping with the transmitter.

[0013] Preferably, the transverse connecting section comprises a first transverse flat section and an upwardly bent connecting portion connected to each other;

[0014] The left side of the first horizontal flat section is connected to the lower part of the right side surface of the first wide vertical section, and the upwardly bent connecting portion is connected to the left side of the implanted sensing section near the upper end.

[0015] Preferably, a convex point is provided at the upper right end of the implanted sensing section; or,

[0016] The upper right end of the implantation sensing section has no convex point, and the position where the implantation needle contacts the upper right end of the implantation sensing section is provided with a pressure contact convex point.

[0017] Preferably, the cross-section of the puncture portion of the implantation needle is C-shaped or concave-shaped, and after assembly, the implantation sensing section is contained in the inner side of the C-shaped or concave-shaped groove.

[0018] A convex point is provided on the upper right end of the implantation sensing segment, and the convex point presses on the inner wall of the implantation needle, so that the implantation sensing segment is deformed with the upward bent connection part as a fulcrum, and the lower end of the implantation sensing segment is contained in the C-shaped inner side or the concave groove of the implantation needle and will not protrude outward from the lower end of the implantation needle; or, the pressure-contact convex point presses on the upper right end of the implantation sensing segment, so that the implantation sensing segment is deformed with the upward bent connection part as a fulcrum, and the lower end of the implantation sensing segment is contained in the C-shaped inner side or the concave groove of the implantation needle and will not protrude outward from the lower end of the implantation needle.

[0019] Preferably, the housing comprises an upper housing and a lower housing, wherein the lower housing covers the lower portion of the upper housing;

[0020] The upper shell is provided with an auxiliary needle guide hole and an electrode guide groove, which are interconnected at the lower part of the upper shell, and the implantation needle passes through the upper part of the auxiliary needle guide hole and extends downward, and the auxiliary needle guide hole is provided beside the lower shell;

[0021] The electrode guide groove runs through the upper shell, wherein the lower section is narrower and the upper section is provided with a countersunk hole, which is a wider structure;

[0022] The transverse part of the implantable sensing electrode extends from the auxiliary needle guide hole, passes through the junction of the lower shell and the upper shell, and enters between the lower shell and the upper shell. The first wide vertical section extends upward from the lower part of the electrode guide groove through the electrode guide groove; the electrode guide groove is a structure with a narrow bottom and a wide top. The width of the narrow bottom part is 0.1~0.3mm larger than the thickness of the first wide vertical section, which is used for glue sealing; the upper wide part provides an escape zone for the bent part of the connector or the connecting piece, and the size is adapted to the connector or the connecting piece assembled on the transmitter. The lower part of the first wide vertical section of the implantable sensing electrode and the lower narrow section of the electrode guide groove are sealed with glue to form a sealing structure; the lower part of the first wide vertical section is provided with a through hole structure or a toothed edge structure for reliable bonding and sealing of glue.

[0023] The transverse part of the implantable sensing electrode is sealed by sealing glue at the junction of the lower shell and the upper shell. The first wide vertical section and the lower narrow structure part of the electrode guide groove are sealed by glue.

[0024] The functions of the electrode guide groove include electrode guiding, sterile airtight cavity sealing, upper countersunk holes avoiding connectors and shrapnel, etc.

[0025] Preferably, a concave stopper is provided at the lower part of the upper shell, a part of the concave stopper is provided with a deep glue-dispensing groove, and a convex stopper is provided at the upper part of the lower shell, and the convex stopper is provided with two adjacent clamping protrusions;

[0026] Sealing glue is set in the concave stopper and the glue dispensing groove, two protrusions are inserted into the glue dispensing groove, the lateral part of the implantable sensing electrode passes through between the two protrusions, and the convex stopper is inserted into the concave stopper. After the sealing glue is cured, the lateral part of the implantable sensing electrode is sealed by the sealing glue at the junction of the lower shell and the upper shell, and the lower shell and the upper shell are sealed.

[0027] Preferably, the needle-assisting guide hole is provided with three steps, the upper step is at the upper part of the upper shell body, the lower step is at the lower part of the upper shell body, the lower parts of the upper step and the middle step are circular holes respectively, the step surface on the circular hole at the middle step is provided with a first sealing ring, and the lower part of the lower step is a notched arc hole;

[0028] The lower part of the needle seat is provided with an open arc section adapted to the notched arc hole, the upper part of the open arc section is a sealing ring adapter part, the sealing ring adapter part is sleeved on the inside of the first sealing ring, the upper part of the sealing ring adapter part is a vertical guide part, the vertical guide part is adapted to the circular hole at the lower part of the upper step surface and has a clearance fit, the upper part of the vertical guide part is an upper boss, and the bottom surface of the upper boss is on the top surface of the upper step.

[0029] The invention also provides a biological information monitoring device.

[0030] A bio-information monitoring device, comprising a transmitter and a compact implantable biosensor assembly;

[0031] The transmitter is provided with a component via, and the compact implantable biosensor component can be detachably passed through the component via and snapped into place at the component via. The transmitter is provided with a main control circuit board, and the main control circuit board is provided with an electrode via. The upper part of the first wide vertical section passes through or approaches the electrode via, and the signal input and output ends of the main control circuit board are connected to the export electrode.

[0032] The structure of the compact implantable biosensor assembly is as described above, including a housing, an implantable sensing electrode, a needle aid, and a barrier;

[0033] The implantable sensing electrode comprises a first wide vertical section, a transverse connecting section and an implantation sensing section, the two sides of the transverse connecting section are respectively connected to the lower end of the first wide vertical section and the upper end of the implantation sensing section, and the surface of the first wide vertical section is provided with a lead-out electrode; the needle-assisting member comprises a needle seat and an implantation needle;

[0034] The implanted sensing section and the lower part of the implantation needle are sealed in a closed space formed by the barrier, the lower part of the housing and the lower part of the needle-assisting member; the transverse connecting section of the implanted sensing electrode is embedded in the housing;

[0035] The lead-out electrode leaks out of the surface of the shell, and the lead-out electrode is used to connect with the emitter; or, the lead-out electrode leaks out of the bottom surface of the upper countersunk hole of the shell, and the lead-out electrode is used to connect with the emitter;

[0036] The housing is provided with an assembly structure for snapping with the transmitter.

[0037] Preferably, the transverse connecting section comprises a first transverse flat section and an upwardly bent connecting portion connected to each other;

[0038] The left side of the first horizontal flat section is connected to the lower part of the right side surface of the first wide vertical section, and the upwardly bent connecting portion is connected to the left side of the implanted sensing section near the upper end.

[0039] Preferably, a convex point is provided at the upper right end of the implanted sensing section; or,

[0040] The upper right end of the implantation sensing section has no convex point, and the position where the implantation needle contacts the upper right end of the implantation sensing section is provided with a pressure contact convex point.

[0041] Preferably, the cross-section of the puncture portion of the implantation needle is C-shaped or concave-shaped, and after assembly, the implantation sensing section is contained in the inner side of the C-shaped or concave-shaped groove.

[0042] A convex point is provided on the upper right end of the implantation sensing segment, and the convex point presses on the inner wall of the implantation needle, so that the implantation sensing segment is deformed with the upward bent connection part as a fulcrum, and the lower end of the implantation sensing segment is contained in the C-shaped inner side or the concave groove of the implantation needle and will not protrude outward from the lower end of the implantation needle; or, the pressure-contact convex point presses on the upper right end of the implantation sensing segment, so that the implantation sensing segment is deformed with the upward bent connection part as a fulcrum, and the lower end of the implantation sensing segment is contained in the C-shaped inner side or the concave groove of the implantation needle and will not protrude outward from the lower end of the implantation needle.

[0043] Preferably, the housing comprises an upper housing and a lower housing, wherein the lower housing covers the lower portion of the upper housing;

[0044] The upper shell is provided with an auxiliary needle guide hole and an electrode guide groove, and the implantation needle passes through the upper part of the auxiliary needle guide hole and extends downward, and the auxiliary needle guide hole is provided beside the lower shell;

[0045] The electrode guide groove runs through the upper shell, wherein the lower section is narrower and the upper section is provided with a countersunk hole, which is a wider structure;

[0046] The transverse portion of the implantable sensing electrode extends from the auxiliary needle guide hole through the junction of the lower shell and the upper shell and enters between the lower shell and the upper shell, and the first wide vertical section passes through the lower part of the electrode guide groove and extends upward;

[0047] The transverse portion of the implantable sensing electrode is sealed by sealing glue at the junction of the lower shell and the upper shell; the first wide vertical section and the lower narrow structural portion of the electrode guide groove are sealed by glue;

[0048] The functions of the electrode guide groove include electrode guiding, sterile airtight cavity sealing, upper countersunk holes avoiding connectors and shrapnel, etc.

[0049] Preferably, a concave stopper is provided at the lower part of the upper shell, a part of the concave stopper is provided with a deep glue-dispensing groove, and a convex stopper is provided at the upper part of the lower shell, and the convex stopper is provided with two adjacent clamping protrusions;

[0050] Sealing glue is set in the concave stopper and the glue dispensing groove, two protrusions are inserted into the glue dispensing groove, the lateral part of the implantable sensing electrode passes through between the two protrusions, and the convex stopper is inserted into the concave stopper. After the sealing glue is cured, the lateral part of the implantable sensing electrode is sealed by the sealing glue at the junction of the lower shell and the upper shell, and the lower shell and the upper shell are sealed.

[0051] Preferably, the needle-assisting guide hole is provided with three steps, the lower parts of the upper step and the middle step are circular holes respectively, the step surface on the circular hole at the middle step is provided with a first sealing ring, and the lower part of the lower step is a notched arc hole;

[0052] The lower part of the needle seat is provided with an open arc section adapted to the notched arc hole, the upper part of the open arc section is a sealing ring adapter part, the sealing ring adapter part is sleeved on the inside of the first sealing ring, the upper part of the sealing ring adapter part is a vertical guide part, the vertical guide part is adapted to the circular hole at the lower part of the upper step surface and has a clearance fit, the upper part of the vertical guide part is an upper boss, and the bottom surface of the upper boss is on the top surface of the upper step.

[0053] Preferably, it also includes a connector, a part of the structure of the connector is connected to the main control circuit board; or, the connector is made of the main control circuit board through an FPC flexible board process or a rigid-flexible board process and other integrated processes.

[0054] The connector is provided with a plurality of first feelers, which are arranged on the left and right sides, the gap distance between the first feelers arranged on the two sides is smaller than the thickness of the first wide vertical section, and the first feelers are arranged on the electrode vias;

[0055] The first wide vertical section passes through the gap between the first antennae arranged on both sides, and the first antennae arranged on both sides squeeze the first wide vertical section from both sides, and at least part of the first antennae are squeezed at the lead-out electrode, and the lead-out electrode is electrically connected to the signal input and output terminal of the main control circuit board through the first antennae.

[0056] The first antennae will be squeezed and deformed, and the first wide vertical section will also be squeezed and slightly deformed, thereby achieving signal communication between the transmitter and the compact implantable biosensor assembly.

[0057] Preferably, the first antennae arranged on both sides are arranged symmetrically on both sides;

[0058] Alternatively, the first antennae arranged on both sides are staggered.

[0059] The first antennae arranged staggered on both sides can be longer than the first antennas arranged symmetrically, and the gap between the two sides is smaller. After the first wide vertical section is inserted into the gap, the bending of the first antennae is longer, and the contact between the first antennae and the contact surface (point contact, line contact or surface contact) of the lead-out electrode is more reliable.

[0060] Preferably, it also includes a connecting sheet;

[0061] The number of the connecting pieces is more than two, one end of the connecting piece is connected to the main control circuit board, and the other end of the connecting piece is pressed against the surface of the lead-out electrode.

[0062] The connecting piece has certain rigidity and elasticity. For example, it is made of copper sheet, stainless steel sheet, etc. and bent into a spring shape. The first wide vertical section extends from the gap between the connecting sheet on one side or both sides of the connecting piece. The connecting piece can effectively squeeze or clamp the lead-out electrode. The elasticity and rigidity of the connecting piece make the connection between the connecting piece and the lead-out electrode connection point more reliable.

[0063] To facilitate welding, the surface of the conductive part of the connecting piece or connector needs to be plated with a solderable coating, such as nickel, gold, etc.; to ensure welding consistency, the end welding end of the connecting piece will pass through the solder foot via hole of the main control circuit board for welding, and the plane welding end will be welded to the surface solder point of the main control circuit board.

[0064] Preferably, the compact implantable biosensor assembly is snapped into place behind the assembly through hole, and at the same time, a spring provided on the housing is inserted into the power switch hole of the transmitter;

[0065] In the initial state, the conductive material on the inner wall of the power switch hole is divided into a left semicircle and a right semicircle, and the left semicircle and the right semicircle are completely disconnected. After the spring is inserted into the power switch hole, the spring is compressed and reliably connects the left semicircle and the right semicircle, thereby realizing power-on of the entire system circuit.

[0066] The spring pins may also be other equivalent conductors.

[0067] Preferably, both side surfaces of the first wide vertical section are provided with lead-out electrodes, and the number of the lead-out electrodes is more than 3;

[0068] Working electrodes, reference electrodes and counter electrodes are arranged on both sides of the implanted sensing segment. The number of the lead-out electrodes is more than 3. The working electrode, reference electrode and counter electrode are respectively connected to different lead-out electrodes through the circuit of the implanted sensing electrode. The working electrode, reference electrode and counter electrode are respectively connected to the signal input and output terminals of the main control circuit board through the lead-out electrodes.

[0069] The beneficial effects of the present invention are as follows: the present invention discloses a compact implantable biosensor component and a biological information monitoring device containing the component, comprising a shell, an implantable sensing electrode, a needle aid and a barrier; the implantable sensing electrode comprises a first wide vertical section, a transverse connecting section and an implanted sensing section, and a lead-out electrode is arranged on the surface of the first wide vertical section; the needle aid comprises a needle seat and an implantation needle; the lower parts of the implanted sensing section and the implantation needle are sealed in a closed space formed by the barrier, the lower part of the shell and the lower part of the needle aid; the transverse connecting section of the implantable sensing electrode is embedded in the shell; the lead-out electrode leaks out of the surface of the shell, and the lead-out electrode is used to connect to the transmitter; or, the lead-out electrode leaks out on the bottom surface of the upper countersunk hole of the shell, and the lead-out electrode is used to connect to the transmitter; the shell is provided with an assembly structure for clamping with the transmitter, and the implantable biosensor component is directly connected to the transmitter circuit board through the lead-out electrode, and the structure is compact. BRIEF DESCRIPTION OF THE DRAWINGS

[0070] The compact implantable biosensor assembly of the present invention is further described below in conjunction with the accompanying drawings.

[0071] Figure 1 It is a schematic diagram of the structural decomposition of a biological information monitoring device of the present invention, including a barrier.

[0072] Figure 2 It is a schematic structural diagram of a biological information monitoring device of the present invention before use, including a barrier.

[0073] Figure 3 It is a schematic diagram of the bottom structure of a transmitter of a biological information monitoring device of the present invention.

[0074] Figure 4 It is a schematic structural diagram of a biological information monitoring device of the present invention from a bottom perspective before use, including a barrier.

[0075] Figure 5 It is an assembly diagram of a compact implantable biosensor assembly of the present invention, including a barrier.

[0076] Figure 6 The figure is a schematic diagram of the bottom structure of a circuit board of an embodiment of a biological information monitoring device of the present invention.

[0077] Figure 7 It is a schematic structural diagram of the cooperation between an implantable sensing electrode and a connector in one embodiment of a biological information monitoring device of the present invention.

[0078] Figure 8 It is a schematic structural diagram of a circuit board of another embodiment of a biological information monitoring device of the present invention, wherein the connecting piece is made of a metal sheet having rigidity and elasticity.

[0079] Fig. 9 It is a structural schematic diagram of a compact implantable biosensor assembly of the present invention from one perspective, without the implantation needle.

[0080] Fig.10 It is a schematic diagram of the exploded structure of part of a compact implantable biosensor assembly of the present invention, viewed from the bottom.

[0081] Fig.11 It is a partial structural exploded schematic diagram of a biological information monitoring device of the present invention, including a needle-assisting part, an upper shell and a spring needle.

[0082] Fig.12 It is a schematic structural diagram of the cooperation between the barrier and the upper shell of a compact implantable biosensor assembly of the present invention.

[0083] Fig.13It is a schematic structural diagram of a circuit board of another embodiment of a biological information monitoring device of the present invention, in which connecting pieces or first antennae are arranged in a staggered manner.

[0084] In the figure:

[0085] 1-housing; 11-upper housing; 110-assembly structure; 111-concave stopper; 1111-dispensing sub-groove; 116-ring-in card slot; 118-assist needle guide hole; 1183-notch arc hole; 119-electrode guide groove; 12-lower housing; 121-convex stopper; 1211-card convex; 15-spring pin; 3-implantable sensing electrode; 31-first wide vertical section; 311-export electrode; 32-lateral connecting section; 321-first horizontal flat section; 322-upward bending connecting portion; 33-implantation sensing section; 331-bump; 4-needle auxiliary piece; 40-needle seat; 401-open arc section; 402-sealing ring adapter; 403-vertical guide; 405-upper boss; 43-implantation needle; 431-pressure contact bump; 48-card gap; 6-barrier; 605-ring card convex; 606-inner card convex; 10-transmitter; 102-component via; 101-main control circuit board; 1011-electrode via; 103-power switch hole; 01-connector; 011-first feeler; 02-connecting piece; 031-first sealing ring. DETAILED DESCRIPTION

[0086] The following is combined with Figures 1 to 13 A compact implantable biosensor assembly of the present invention is further described.

[0087] A compact implantable biosensor assembly comprises a housing 1, an implantable sensing electrode 3, a needle-assisting member 4 and a barrier 6;

[0088] The implantable sensing electrode 3 includes a first wide vertical section 31, a transverse connecting section 32 and an implant sensing section 33. The two sides of the transverse connecting section 32 are respectively connected to the lower end of the first wide vertical section 31 and the upper end of the implant sensing section 33. The surface of the first wide vertical section 31 is provided with a lead-out electrode 311. The needle-assisting member 4 includes a needle seat 40 and an implantation needle 43.

[0089] The implanted sensing section 33 and the lower part of the implantation needle 43 are sealed in a closed space formed by the barrier 6, the lower part of the housing 1 and the lower part of the needle-assisting member 4; the transverse connecting section 32 of the implanted sensing electrode 3 is embedded in the housing 1;

[0090] The lead-out electrode 311 leaks out of the surface of the housing 1, and the lead-out electrode 311 is used to connect with the transmitter 10; or, the lead-out electrode 311 leaks out of the bottom surface of the upper countersunk hole of the housing 1, and the lead-out electrode 311 is used to connect with the transmitter 10;

[0091] The housing 1 is provided with an assembly structure 110 for snap-fitting with the transmitter 10 .

[0092] The transmitter 10 includes a main control circuit board 101, a main support structure 105 and an upper cover 106. The assembly structure 110 includes two assembly protrusions 1101. Two assembly pits 1021 are arranged in the component via 102 of the main support structure 105. The assembly protrusions 1101 are inserted into the assembly pits 1021 to achieve assembly.

[0093] In this embodiment, the transverse connecting section 32 includes a first transverse flat section 321 and an upwardly bent connecting portion 322 connected to each other;

[0094] The left side of the first horizontal flat section 321 is connected to the lower part of the right side surface of the first wide vertical section 31 , and the upwardly bent connecting portion 322 is connected to the left side of the implanted sensing section 33 near the upper end.

[0095] In this embodiment, a convex point 331 is provided at the upper right end of the implanted sensing section 33; or,

[0096] There is no bump 331 on the upper right side of the implantation sensing section 33 , and a pressure contact bump 431 is provided at the portion where the implantation needle 43 contacts the upper right side of the implantation sensing section 33 .

[0097] In this embodiment, the cross-section of the puncture portion of the implantation needle 43 is C-shaped or concave-shaped. After assembly, the implantation sensing section 33 is contained in the inner side of the C-shaped or concave-shaped groove.

[0098] A convex point 331 is provided at the upper right end of the implant sensing segment 33, and the convex point 331 presses on the inner wall of the implant needle 43, so that the implant sensing segment 33 is deformed with the upward bent connection part 322 as a fulcrum, and the lower end of the implant sensing segment 33 is contained in the C-shaped inner side or the concave groove of the implant needle 43 and will not protrude outward from the lower end of the implant needle 43; or, the pressing convex point 431 presses on the upper right end of the implant sensing segment 33, so that the implant sensing segment 33 is deformed with the upward bent connection part 322 as a fulcrum, and the lower end of the implant sensing segment 33 is contained in the C-shaped inner side or the concave groove of the implant needle 43 and will not protrude outward from the lower end of the implant needle 43.

[0099] In this embodiment, the housing 1 includes an upper housing 11 and a lower housing 12, wherein the lower housing 12 covers the lower portion of the upper housing 11;

[0100] The upper shell 11 is provided with an auxiliary needle guide hole 118 and an electrode guide groove 119, which are connected to each other at the lower part of the upper shell 11, and the implantation needle 43 passes through the upper part of the auxiliary needle guide hole 118 and extends downward, and the auxiliary needle guide hole 118 is provided beside the lower shell 12;

[0101] The electrode guide groove 119 is arranged at the upper part of the lower shell 12, wherein the lower part is narrower and the upper part is provided with a countersunk hole, which is a wider structure;

[0102] The lateral portion of the implantable sensing electrode 3 extends from the auxiliary needle guide hole 118, passes through the junction of the lower shell 12 and the upper shell 11, and enters between the lower shell 12 and the upper shell 11. The first wide vertical section 31 extends upward from the lower part of the electrode guide groove 119; the electrode guide groove 119 is a narrow bottom and wide top structure, and the width of the narrow lower part is 0.1~0.3mm larger than the thickness of the first wide vertical section 31, which is used for glue sealing; the wide upper part provides an avoidance interval for the bending part of the connector 01 or the connecting piece 02, and the size is adapted to the connector 01 or the connecting piece 02 assembled on the transmitter 10.

[0103] The lower part of the first wide vertical section 31 of the implantable sensing electrode 3 and the lower narrow section of the electrode guide groove 119 are sealed by glue to form a sealing structure; the lower part of the first wide vertical section 31 is provided with a through hole structure or a toothed edge structure for reliable bonding and sealing of the glue.

[0104] The lateral part of the implantable sensing electrode 3 is sealed by sealing glue at the junction of the lower shell 12 and the upper shell 11. The narrow part of the lower section of the electrode guide groove and the lower part of the first wide vertical section 31 of the electrode form a sealing structure by glue;

[0105] The functions of the electrode guide groove 119 include avoiding the upper countersunk hole, positioning the electrode of the lower narrow structure and glue sealing.

[0106] In this embodiment, a concave stopper 111 is provided at the lower part of the upper shell 11, and a deep glue-dispensing groove 1111 is partially provided at the concave stopper 111. A convex stopper 121 is provided at the upper part of the lower shell 12, and the convex stopper 121 is provided with two adjacent clamping protrusions 1211.

[0107] Sealing glue is set in the concave stopper 111 and the glue-dispensing groove 1111, two protrusions 1211 are inserted into the glue-dispensing groove 1111, and the transverse part of the implantable sensing electrode 3 passes between the two protrusions 1211. The protrusion stopper 121 is inserted into the concave stopper 111. After the sealing glue is cured, the transverse part of the implantable sensing electrode 3 is sealed by the sealing glue at the junction of the lower shell 12 and the upper shell 11, and the lower shell 12 and the upper shell 11 are sealed. The lower part of the first wide vertical section 31 of the implantable sensing electrode 3 and the lower narrow section of the guide groove 119 are sealed by glue to form a sealing structure; the lower part of the first wide vertical section 31 is provided with a through hole structure or / and a tooth edge structure for reliable bonding and sealing of the glue.

[0108] In this embodiment, the needle guide hole 118 is provided with three steps, the lower parts of the upper step and the middle step are circular holes, the step surface on the circular hole at the middle step is provided with a first sealing ring 031, and the lower part of the lower step is a notched arc hole 1183;

[0109] The lower part of the needle seat 40 is provided with an open arc section 401 adapted to the notched arc hole 1183, the upper part of the open arc section 401 is a sealing ring adapter part 402, the sealing ring adapter part 402 is sleeved on the inside of the first sealing ring 031, the upper part of the sealing ring adapter part 402 is a vertical guide part 403, the vertical guide part 403 is adapted to the circular hole at the lower part of the upper step surface and has a clearance fit, the upper part of the vertical guide part 403 is an upper boss 405, and the bottom surface of the upper boss 405 is on the top surface of the upper step.

[0110] The barrier 6 includes a rubber plug 603, a barrier main shell 602 and a barrier sealing ring 601. The barrier sealing ring 601 is arranged at the end of the barrier main shell 602 and is integrally formed by two-color injection molding. The lower part of the barrier main shell 602 cooperates with the rubber plug 603. The rubber plug 603 is made of soft rubber material. The rubber plug 603 is inserted into the lower part of the barrier main shell 602 and squeezed to form a seal.

[0111] The barrier 6 is in the shape of a hollow barrel as a whole. A symmetrical ring-entry convexity 605 is provided on the outer side of the upper part of the barrier 6, and an inner convexity 606 is provided on the inner side of the upper part of the barrier 6. The outer ring-entry convexity 605 of the barrier 6 is respectively engaged with the ring-entry groove 116 at the bottom of the shell 1, and the inner convexity of the barrier 6 is engaged with the notch 48 of the needle seat 40 of the needle-assisting part. The engagement of the barrier 6 with the shell 1 and the needle-assisting part 4 is detachable, and the engagement or release of the buckle can be achieved by rotating the barrier 6. A barrier sealing ring 601 is provided on the upper part of the barrier 6. The barrier sealing ring 601 and the barrier 6 are integrally formed by two-color injection molding. When the barrier 6 is engaged by rotating, the barrier sealing ring 601 squeezes between the lower part of the lower shell 12 and the upper part of the barrier 6 to form a seal.

[0112] The sealing ring 4 is placed on the first step from top to bottom, and the second step cooperates with the anti-fool surface of the auxiliary needle to effectively prevent the auxiliary needle from rotating.

[0113] The housing 1 comprises an upper housing 11 and a lower housing 12, wherein the lower housing 12 covers the lower part of the upper housing 11;

[0114] The upper housing 11 is provided with

[0115] The invention also provides a biological information monitoring device.

[0116] A biological information monitoring device includes a transmitter 10 and a compact implantable biosensor assembly;

[0117] The transmitter 10 is provided with a component via 102, and the compact implantable biosensor component can be detachably passed through the component via 102 and snapped into the component via 102. The transmitter 10 is provided with a main control circuit board 101, and the main control circuit board 101 is provided with an electrode via 1011. The upper part of the first wide vertical section 31 passes through or approaches the electrode via 1011, and the signal input and output ends of the main control circuit board 101 are connected to the export electrode 311.

[0118] The compact implantable biosensor assembly comprises a housing 1, an implantable sensing electrode 3, a needle aid 4 and a barrier 6;

[0119] The implantable sensing electrode 3 includes a first wide vertical section 31, a transverse connecting section 32 and an implant sensing section 33. The two sides of the transverse connecting section 32 are respectively connected to the lower end of the first wide vertical section 31 and the upper end of the implant sensing section 33. The surface of the first wide vertical section 31 is provided with a lead-out electrode 311. The needle-assisting member 4 includes a needle seat 40 and an implantation needle 43.

[0120] The implanted sensing section 33 and the lower part of the implantation needle 43 are sealed in a closed space formed by the barrier 6, the lower part of the housing 1 and the lower part of the needle-assisting member 4; the transverse connecting section 32 of the implanted sensing electrode 3 is embedded in the housing 1;

[0121] The lead-out electrode 311 leaks out of the surface of the housing 1, and the lead-out electrode 311 is used to connect with the transmitter 10; or, the lead-out electrode 311 leaks out of the bottom surface of the upper countersunk hole of the housing 1, and the lead-out electrode 311 is used to connect with the transmitter 10;

[0122] The housing 1 is provided with an assembly structure 110 for snap-fitting with the transmitter 10 .

[0123] In this embodiment, the transverse connecting section 32 includes a first transverse flat section 321 and an upwardly bent connecting portion 322 connected to each other;

[0124] The left side of the first horizontal flat section 321 is connected to the lower part of the right side surface of the first wide vertical section 31 , and the upwardly bent connecting portion 322 is connected to the left side of the implanted sensing section 33 near the upper end.

[0125] In this embodiment, a convex point 331 is provided at the upper right end of the implanted sensing section 33; or,

[0126] There is no bump 331 on the upper right side of the implantation sensing section 33 , and a pressure contact bump 431 is provided at the portion where the implantation needle 43 contacts the upper right side of the implantation sensing section 33 .

[0127] In this embodiment, the cross-section of the puncture portion of the implantation needle 43 is C-shaped or concave-shaped. After assembly, the implantation sensing section 33 is contained in the inner side of the C-shaped or concave-shaped groove.

[0128] A convex point 331 is provided at the upper right end of the implant sensing segment 33, and the convex point 331 presses on the inner wall of the implant needle 43, so that the implant sensing segment 33 is deformed with the upward bent connection part 322 as a fulcrum, and the lower end of the implant sensing segment 33 is contained in the C-shaped inner side or the concave groove of the implant needle 43 and will not protrude outward from the lower end of the implant needle 43; or, the pressing convex point 431 presses on the upper right end of the implant sensing segment 33, so that the implant sensing segment 33 is deformed with the upward bent connection part 322 as a fulcrum, and the lower end of the implant sensing segment 33 is contained in the C-shaped inner side or the concave groove of the implant needle 43 and will not protrude outward from the lower end of the implant needle 43.

[0129] In this embodiment, the housing 1 includes an upper housing 11 and a lower housing 12, wherein the lower housing 12 covers the lower portion of the upper housing 11;

[0130] The upper shell 11 is provided with an auxiliary needle guide hole 118 and an electrode guide groove 119. The implantation needle 43 passes through the upper part of the auxiliary needle guide hole 118 and extends downward. The auxiliary needle guide hole 118 is provided beside the lower shell 12.

[0131] The electrode guide groove 119 is provided at the upper portion of the lower housing 12;

[0132] The transverse portion of the implantable sensing electrode 3 extends from the auxiliary needle guide hole 118 through the junction of the lower shell 12 and the upper shell 11 and enters between the lower shell 12 and the upper shell 11, and the first wide vertical section 31 extends upward through the lower part of the electrode guide groove 119;

[0133] The lateral portion of the implantable sensing electrode 3 is sealed by sealing glue at the junction of the lower housing 12 and the upper housing 11 .

[0134] The function of the electrode guide groove 119 is the function of the upper countersunk hole.

[0135] In this embodiment, a concave stopper 111 is provided at the lower part of the upper shell 11, and a deep glue-dispensing groove 1111 is partially provided at the concave stopper 111. A convex stopper 121 is provided at the upper part of the lower shell 12, and the convex stopper 121 is provided with two adjacent clamping protrusions 1211.

[0136] Sealing glue is set in the concave stop 111 and the glue dispensing groove 1111, and the two protrusions 1211 are inserted into the glue dispensing groove 1111. The lateral part of the implantable sensing electrode 3 passes through between the two protrusions 1211, and the convex stop 121 is inserted into the concave stop 111. After the sealing glue is cured, the lateral part of the implantable sensing electrode 3 is sealed by the sealing glue at the junction of the lower shell 12 and the upper shell 11, and the lower shell 12 and the upper shell 11 are sealed.

[0137] In this embodiment, the needle guide hole 118 is provided with three steps, the upper step is at the upper part of the upper shell 11, the lower step is at the lower part of the upper shell 11, the lower parts of the upper step and the middle step are circular holes respectively, the step surface on the circular hole at the middle step is provided with a first sealing ring 031, and the lower part of the lower step is a notched arc hole 1183; the upper periphery of the upper shell 11 is provided with a second sealing ring 112, the edge of the upper step surface is provided with a third sealing ring 113, the second sealing ring 112 and the third sealing ring 113 are provided with,

[0138] The lower part of the needle seat 40 is provided with an open arc section 401 adapted to the notched arc hole 1183, the upper part of the open arc section 401 is a sealing ring adapter part 402, the sealing ring adapter part 402 is sleeved on the inside of the first sealing ring 031, the upper part of the sealing ring adapter part 402 is a vertical guide part 403, the vertical guide part 403 is adapted to the circular hole at the lower part of the upper step surface and has a clearance fit, the upper part of the vertical guide part 403 is an upper boss 405, and the bottom surface of the upper boss 405 is on the top surface of the upper step.

[0139] In this embodiment, a connector 01 is also included, and part of the structure of the connector 01 is connected to the main control circuit board 101; as an alternative, the connector 01 is integrally processed by the main control circuit 101 through an FPC flexible board process or a rigid-flexible board process.

[0140] The connector 01 is provided with a plurality of first antennae 011, which are arranged on the left and right sides, and the gap distance between the first antennae 011 arranged on the two sides is smaller than the thickness of the first wide vertical section 31, and the first antennae 011 are arranged on the electrode via 1011;

[0141] The first wide vertical section 31 passes through the gap between the first antennae 011 arranged on both sides. The first antennae 011 arranged on both sides squeeze the first wide vertical section 31 from both sides. At least part of the first antennae 011 are squeezed at the lead-out electrode 311. The lead-out electrode 311 is electrically connected to the signal input and output terminals of the main control circuit board 101 through the first antennae 011.

[0142] The first antenna 011 will be squeezed and deformed, and the first wide vertical section 31 will also be squeezed and slightly deformed, thereby achieving signal communication between the transmitter 10 and the compact implantable biosensor assembly.

[0143] In this embodiment, the first antennae 011 arranged on both sides are arranged symmetrically on both sides;

[0144] Alternatively, the first antennae 011 arranged on both sides are arranged staggered on both sides.

[0145] The first antenna 011 arranged staggered on both sides can be longer than the first antenna 011 arranged symmetrically, and the gap between the two sides is smaller. After the first wide vertical section 31 is inserted into the gap, the bending of the first antenna 011 is longer, and the contact surface (point contact, line contact or surface contact) between the first antenna 011 and the lead-out electrode 311 is more reliable.

[0146] In this embodiment, a connecting piece 02 is also included;

[0147] The number of the connecting pieces 02 is more than two. One end of the connecting piece 02 is connected to the main control circuit board 101 , and the other end of the connecting piece 02 is pressed against the surface of the lead-out electrode 311 .

[0148] The connecting piece 02 has certain rigidity and elasticity, for example, it is made of copper sheet, stainless steel sheet, etc. and bent into a spring shape. The first wide vertical section 31 extends from the gap of the connecting piece 02 on one side or both sides of the connecting piece 02. The connecting piece 02 can effectively squeeze or clamp the lead-out electrode 311. The elasticity and rigidity of the connecting piece 02 make the connection between the connecting piece 02 and the connecting point of the lead-out electrode 311 more reliable.

[0149] To facilitate welding, the surface of the conductive part of the connecting piece 02 or the connector 01 needs to be plated with a solderable coating, such as nickel, gold, etc.; for welding consistency, the end welding end of the connecting piece 02 will pass through the solder foot via hole of the main control circuit board 101 for welding, and the plane welding end and the surface solder point of the main control circuit board 101 will be welded.

[0150] In this embodiment, the compact implantable biosensor component is snapped into the component through hole 102, and at the same time, the spring pin 15 provided on the housing 1 is inserted into the power switch hole 103 of the transmitter 10;

[0151] In the initial state, the conductive material on the inner wall of the power switch hole 103 is divided into a left semicircle and a right semicircle, and the left semicircle and the right semicircle are completely disconnected. After the spring pin 15 is inserted into the power switch hole 103, the spring pin 15 is compressed and reliably connects the left semicircle and the right semicircle, thereby realizing power-on of the entire system circuit.

[0152] The spring pins may also be other equivalent conductors.

[0153] In this embodiment, both side surfaces of the first wide vertical section 31 are provided with lead-out electrodes 311 , and the number of lead-out electrodes 311 is more than 3;

[0154] Working electrodes, reference electrodes and counter electrodes are arranged on both sides of the implanted sensing segment 33. The number of the lead-out electrodes 311 is more than 3. The working electrode, reference electrode and counter electrode are respectively connected to different lead-out electrodes 311 through the circuit of the implanted sensing electrode 3. The working electrode, reference electrode and counter electrode are respectively connected to the signal input and output terminals of the main control circuit board 101 through the lead-out electrodes 311.

[0155] The implant sensing segment and the lower part of the implant needle are sealed in a confined space formed by the barrier, the lower part of the outer shell and the lower part of the needle aid; the sealed space constitutes a smaller disinfection and sterilization unit. The small size of the disinfection and sterilization unit can improve production efficiency and reduce production costs. Before being implanted into the human body, the transmitter does not need to consume electricity or consumes very little electricity, which can increase the shelf life of the transmitter.

[0156] The above description is only a preferred embodiment of the present invention. It should be pointed out that a person skilled in the art can make several improvements without departing from the principle of the present invention, and these improvements should also be regarded as within the protection scope of the present invention.

Claims

1. A compact implantable biosensor assembly comprising a housing (1), It is characterized in that It also includes an implantable sensing electrode (3), a needle aid (4) and a barrier (6); The implantable sensing electrode (3) comprises a first wide vertical section (31), a transverse connecting section (32) and an implant sensing section (33), the two sides of the transverse connecting section (32) respectively connecting the lower end of the first wide vertical section (31) and the upper end of the implant sensing section (33), and the surface of the first wide vertical section (31) is provided with a lead-out electrode (311); the needle-assisting member (4) comprises a needle seat (40) and an implantation needle (43); The lower part of the implantable sensing section (33) and the implantation needle (43) are sealed in a closed space formed by the barrier (6), the lower part of the housing (1) and the lower part of the needle assisting member (4); the transverse connecting section (32) of the implantable sensing electrode (3) is embedded in the housing (1); The lead-out electrode (311) leaks out of the surface of the housing (1), and the lead-out electrode (311) is used to connect to the transmitter (10); or, the lead-out electrode (311) leaks out of the bottom surface of the upper countersunk hole of the housing (1), and the lead-out electrode (311) is used to connect to the transmitter (10); The housing (1) is provided with an assembly structure (110) for being snap-connected with the transmitter (10); The housing (1) comprises an upper housing (11) and a lower housing (12), wherein the lower housing (12) covers the lower part of the upper housing (11); The upper shell (11) is provided with an auxiliary needle guide hole (118) and an electrode guide groove (119), the auxiliary needle guide hole (118) and the electrode guide groove (119) are connected to each other at the lower part of the upper shell (11), and the implantation needle (43) passes through the upper part of the auxiliary needle guide hole (118) and extends downward; The electrode guide groove (119) is arranged on the upper part of the lower shell (12); The transverse portion of the implantable sensing electrode (3) extends from the auxiliary needle guide hole (118) through the junction of the lower shell (12) and the upper shell (11) and enters between the lower shell (12) and the upper shell (11), and the first wide vertical section (31) extends upward from the lower part of the electrode guide groove (119) through the electrode guide groove (119); the transverse portion of the implantable sensing electrode (3) is sealed by sealing glue at the junction of the lower shell (12) and the upper shell (11); The barrier (6) is in the shape of a hollow barrel as a whole, and a symmetrical ring-entry convexity (605) is provided on the outer side of the upper part of the barrier (6), and an inner convexity (606) is provided on the inner side of the upper part of the barrier (6); The bottom of the upper shell (11) is provided with an annular groove (116), the lower part of the needle seat (40) is provided with a notch (48), the outer annular protrusions (605) of the barrier (6) are respectively engaged with the annular groove (116) at the bottom of the shell (1), and the inner protrusions (606) of the barrier (6) are engaged with the notch (48) of the needle seat (40).

2. The compact implantable biosensor assembly as claimed in claim 1, It is characterized in that The transverse connecting section (32) comprises a first transverse flat section (321) and an upwardly bent connecting portion (322) which are connected to each other; The left side of the first horizontal flat section (321) is connected to the lower part of the right side surface of the first wide vertical section (31), and the upwardly bent connecting portion (322) is connected to the left side of the implanted sensing section (33) close to the upper end.

3. The compact implantable biosensor assembly as claimed in claim 2, It is characterized in that A convex point (331) is provided at the upper right end of the implanted sensing section (33); or, The upper right end of the implant sensing section (33) has no convex point (331), and the portion where the implant needle (43) contacts the upper right end of the implant sensing section (33) is provided with a pressure contact convex point (431).

4. The compact implantable biosensor assembly as claimed in claim 3, It is characterized in that The cross section of the puncture portion of the implantation needle (43) is C-shaped or concave-shaped. After assembly, the implantation sensing section (33) is contained in the inner side of the C-shaped groove or the concave-shaped groove.

5. The compact implantable biosensor assembly as claimed in claim 1, It is characterized in that The electrode guide groove (119) is a structure that is narrow at the bottom and wide at the top. The width of the narrow portion at the bottom is 0.1 to 0.3 mm greater than the thickness of the first wide vertical section (31) and is used for glue sealing. The wide portion at the top provides an escape zone for the bent portion of the connector (01) or the connecting piece (02), and the size is adapted to fit the connector (01) or the connecting piece (02) mounted on the transmitter (10). The lower part of the first wide vertical section (31) of the implantable sensing electrode (3) and the lower narrow section of the electrode guide groove (119) are sealed with glue to form a sealing structure; the lower part of the first wide vertical section (31) is provided with a through hole structure or a toothed edge structure for reliable bonding and sealing of the glue.

6. The compact implantable biosensor assembly as claimed in claim 1, It is characterized in that A concave stopper (111) is provided at the lower part of the upper shell (11), a part of the concave stopper (111) is provided with a relatively deep glue-dispensing groove (1111), and a convex stopper (121) is provided at the upper part of the lower shell (12), and the convex stopper (121) is provided with two adjacent locking protrusions (1211); Sealing glue is provided in the concave stopper (111) and the glue dispensing groove (1111), the two clamping protrusions (1211) are inserted into the glue dispensing groove (1111), the lateral portion of the implantable sensing electrode (3) passes through between the two clamping protrusions (1211), and the convex stopper (121) is clamped into the concave stopper (111), and after the sealing glue is cured, the lateral portion of the implantable sensing electrode (3) and the junction between the lower shell (12) and the upper shell (11) are sealed by the sealing glue, and the lower shell (12) and the upper shell (11) are sealed; The lower part of the first wide vertical section (31) of the implantable sensing electrode (3) and the lower narrow section of the electrode guide groove (119) are sealed with glue to form a sealing structure; the lower part of the first wide vertical section (31) is provided with a through hole structure and / or a toothed edge structure for reliable bonding and sealing of the glue.

7. The compact implantable biosensor assembly as claimed in claim 1, It is characterized in that The auxiliary needle guide hole (118) is provided with three steps, the upper step is at the upper part of the upper shell (11), and the lower step is at the lower part of the upper shell (11); the lower parts of the upper step and the middle step are respectively circular holes, the step surface on the circular hole at the middle step is provided with a first sealing ring (031), and the lower part of the lower step is a notched arc hole (1183); The lower part of the needle seat (40) is provided with an open arc section (401) adapted to the notched arc hole (1183); the upper part of the open arc section (401) is a sealing ring adapter (402); the sealing ring adapter (402) is sleeved inside the first sealing ring (031); the upper part of the sealing ring adapter (402) is a vertical guide (403); the vertical guide (403) is adapted to the circular hole at the lower part of the upper step surface and has a clearance fit; the upper part of the vertical guide (403) is an upper boss (405); the bottom surface of the upper boss (405) is on the top surface of the upper step.

8. A biological information monitoring device, comprising a transmitter (10), It is characterized in that Also includes the compact implantable biosensor assembly according to any one of claims 1 to 7; The transmitter (10) is provided with a component via hole (102), the compact implantable biosensor component can be detachably passed through the component via hole (102) and snapped into place at the component via hole (102), the transmitter (10) is provided with a main control circuit board (101), the main control circuit board (101) is provided with an electrode via hole (1011), the upper portion of the first wide vertical section (31) passes through or is close to the electrode via hole (1011), and the signal input and output ends of the main control circuit board (101) are connected to the lead-out electrode (311).

9. The biological information monitoring device according to claim 8, It is characterized in that It also comprises a connector (01), a part of the structure of the connector (01) being connected to the main control circuit board (101), or the connector (01) being integrally processed by the main control circuit board (101) through an FPC flexible board process or a rigid-flexible board process; The connector (01) is provided with a plurality of first antennae (011), the plurality of first antennae (011) are arranged on the left and right sides, the gap distance between the first antennae (011) arranged on the two sides is smaller than the thickness of the first wide vertical section (31), and the first antennae (011) are arranged on the electrode via (1011); The first wide vertical segment (31) passes through the gap between the first antennae (011) arranged on both sides. The first antennae (011) arranged on both sides squeeze the first wide vertical segment (31) from both sides, and at least a part of the first antennae (011) is squeezed at the lead-out electrode (311). The lead-out electrode (311) is electrically connected to the signal input / output terminal of the main control circuit board (101) through the first antennae (011).

10. The biological information monitoring device according to claim 9, wherein, the first antennae (011) arranged on both sides are symmetrically arranged on both sides; or, the first antennae (011) arranged on both sides are staggeredly arranged on both sides.

11. The biological information monitoring device according to claim 8, wherein, it further includes a connecting piece (02); the number of the connecting pieces (02) is more than two. One end of the connecting piece (02) is connected to the main control circuit board (101), and the other end of the connecting piece (02) presses against the surface of the lead-out electrode (311).

12. The biological information monitoring device according to claim 8, wherein, after the compact implantable biosensor assembly is clamped in the assembly through-hole (102), at the same time, the spring pin (15) arranged on the housing (1) is inserted into the power switch hole (103) of the transmitter (10); In the initial state, the conductive material on the inner wall of the power switch hole (103) is divided into a left semi-circle and a right semi-circle, and there is a complete disconnection between the left semi-circle and the right semi-circle. After the spring pin (15) is inserted into the power switch hole (103), the spring pin (15) is compressed and reliably connects the left semi-circle and the right semi-circle to realize the power-on of the entire system circuit.

13. The biological information monitoring device according to claim 12, wherein, lead-out electrodes (311) are arranged on both side surfaces of the first wide vertical segment (31), and the number of the lead-out electrodes (311) is more than 3; working electrodes, reference electrodes and counter electrodes are arranged on both sides of the implantable sensing segment (33). The number of the lead-out electrodes (311) is more than 3. The working electrodes, reference electrodes and counter electrodes are respectively connected to different lead-out electrodes (311) through the lines of the implantable sensing electrodes (3), and the working electrodes, reference electrodes and counter electrodes are respectively connected to the signal input / output terminals of the main control circuit board (101) through the lead-out electrodes (311).

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