Syringe, syringe body and method of manufacturing a syringe body

Abstract

The invention relates to a syringe comprising a syringe body with a nozzle and a threaded joint. The syringe body comprises a side wall and an end wall, wherein the syringe body at least partially comprises a cyclic olefin as a first material. The first material forms the inner wall of the syringe body. The threaded joint at least partially comprises a material different from the cyclic olefin as a second material, wherein the first material and the second material are connected to each other in a material bond. The second material extends at least in sections onto the first material in the area of the end wall, so that the end wall comprises at least in sections a two-layer area. In the two-layer area, the first and the second material have structural parts which are nested into each other.

Description

Technical Field

[0001] The present invention relates to a syringe pre-filled with medical fluid, the syringe comprising a syringe body having a Luer-Lock-Anschluss connector and a method for manufacturing the syringe body. Background Technology

[0002] Pre-filled syringes, also known as disposable syringes, may include a plastic syringe body. For dispensing the medical fluid within, the end face of the syringe body has a nozzle. This nozzle, for example, can be used to connect a needle or tubing to a delivery system. Syringes with male Luer lock connectors are particularly widely used. Here, the standard tapered nozzle is surrounded by a sleeve with internal threads.

[0003] Especially in the case of pre-filled syringes, suitable plastic materials should meet different requirements.

[0004] The plastic material should be suitable for as many different medical fluids as possible. In particular, it is essential to minimize the diffusion of medical fluid components into the material, and to prevent the extraction of material components through the medical fluid during long-term storage. Furthermore, a suitable plastic material should also be autoclave-safe.

[0005] Cyclic olefin copolymers have been identified as particularly suitable materials. On the one hand, they are easily processed in injection molding. On the other hand, they possess high stiffness and hardness while maintaining a relatively low density. Furthermore, these materials are amorphous and highly transparent. They also exhibit low water absorption and low water vapor permeability.

[0006] However, these plastics can be relatively brittle. For example, cyclic olefin copolymers have a relatively low elongation at break compared to polypropylene or polyethylene. This can cause damage to the Luer lock threads of the syringe, for instance, when the connector in the delivery system is tightened incorrectly. Because of the material's brittleness, it cannot undergo significant plastic deformation, so this type of damage occurs suddenly. Therefore, the user receives almost no tactile feedback indicating that they have tightened the connector too much.

[0007] To mitigate this problem, published patent application DE 10 2017 112 823 A1 proposes using ribs to reinforce the threaded sleeve. This improves the mechanical stability of the threaded joint.

[0008] The published patent application EP 3 342 441 A1 proposes providing a threaded connector made of a different material than the syringe body. It specifically proposes that the connector, made of a softer material, is injection-molded onto the remainder of the syringe base. Summary of the Invention

[0009] Therefore, the object of the present invention is to at least reduce the problems mentioned in the prior art.

[0010] The objective of this invention is particularly to provide a pre-filled plastic syringe for medical use, comprising an inner wall made of a material having high chemical resistance and good barrier properties, and also providing a stable plastic threaded connector.

[0011] The object of the present invention is achieved by the syringe body, syringe, and method of manufacturing the syringe body according to the independent claims.

[0012] Preferred embodiments and further improvements of the invention can be obtained from the subject matter of the dependent claims, the description, and the drawings.

[0013] According to a first aspect, the present invention relates to a syringe body for a syringe, comprising a syringe base having sidewalls, an endwall, and a nozzle disposed on the front side of the endwall.

[0014] The syringe matrix at least partially comprises a cyclic olefin as a first material, which forms at least one inner wall of the syringe matrix.

[0015] The connector with a threaded joint is positioned at its rear end on the front side of the syringe body end wall. This connector, in particular, at least partially comprises a second material, i.e., a material different from the first material.

[0016] The syringe base and connectors are joined together by materials to form the syringe body.

[0017] Furthermore, the complementary structural parts on the front side of the syringe base end wall and the rear side of the connector are nested and joined together.

[0018] This invention specifically specifies that at least the inner wall, preferably the entire sidewall, of the syringe matrix comprises a cyclic olefin. In particular, the entire syringe matrix is ​​provided with a cyclic olefin.

[0019] The first material preferably consists of at least 50% (by weight) cyclic olefins, and particularly preferably at least 90% (by weight) cyclic olefins.

[0020] In this invention, cycloolefins are understood to be all cycloolefin copolymers obtained through catalytic copolymerization of cycloolefins. In the context of this invention, cycloolefins are also understood to be materials obtained through ring-opening salt metathesis. Strictly speaking, these materials are not called cycloolefin copolymers, but rather cycloolefin polymers. Cycloolefins can also be formed into a chrystal-clear polymer.

[0021] This material is amorphous and transparent, and compared to other plastics, it exhibits significantly lower interaction with filled medical fluids, particularly aqueous medical fluids or emulsions.

[0022] According to the present invention, the syringe body is composed of a syringe base and a connector, including a threaded connector formed of a material different from that of the syringe base.

[0023] To achieve a well-bonded connection, specifically through injection molding, the connector with threaded joint is formed such that a second material at least partially covers the first material at the end face. Therefore, the end face of the syringe body is at least partially formed with two layers.

[0024] In the region of the end wall of the two-layer structure, the first and second materials comprise structural parts (Strukturierung) that are nested and joined together with each other.

[0025] The structural section can be understood as a regular or irregular height profile of the first material with protrusions or depressions. For example, the second material injected during injection molding engages with the depression. This structure can also be viewed as a cross-section with peaks and valleys, where the valleys are filled with other materials. The surfaces made of the first and second materials, adjacent to each other in the boundary regions of the two layers, each include surface irregularities with a cross-sectional structure. The cross-sectional structure is filled with other materials.

[0026] It has been found that the tendency of two-layer materials to separate, especially under autoclaving and / or mechanical stress, can be significantly reduced.

[0027] For example, the strain caused by the different coefficients of thermal expansion of materials is not only distributed radially along a smooth surface due to peaks and valleys, but is also guided around in the axial direction in part.

[0028] The linear coefficient of thermal expansion (under standard conditions) of cyclic olefin copolymers is typically less than 60 x 10⁻⁶. 6 x K 1 In contrast, polypropylene has a significantly higher coefficient of thermal expansion, especially exceeding 150 x 10⁻⁶. 6 x K 1 .

[0029] Despite the strength and certain brittleness of cyclic olefin copolymers, the different thermal expansion of the two materials, especially during autoclaving, will not cause the bond between the materials to break.

[0030] Furthermore, the surface area of ​​the boundary region between the first and second materials is also enlarged by the structural section. This boundary region is preferably at least 20% larger than a design without a structural section.

[0031] Finally, through the structural section, when the connector is connected to the threaded joint, especially relative to the torque between the components, a form-fit connection can be provided between the first and second materials.

[0032] Therefore, improved mechanical connections can be provided in a very simple way.

[0033] Preferably, the injection molding coating of the nozzle with a second material can be omitted. Therefore, when used as intended, it is preferable to avoid any contact between the medical liquid and the second material.

[0034] Manufacturing such a syringe does not significantly increase costs. Therefore, the syringe base can be manufactured using an injection molding die that includes a negative profile of the syringe base's outline shape.

[0035] According to the present invention, the front side of the syringe base end wall and the rear side of the connector are connected to each other by material bonding.

[0036] In one embodiment of the invention, the connector is provided as a separate component mounted on the syringe base. The connector is attached to the syringe base, in particular, by adhesion and / or welding.

[0037] In another embodiment of the material bonding, the connector is injection molded onto the syringe base.

[0038] Protrusions can be regular or irregular. Depressions can be regular or irregular.

[0039] In one embodiment of the invention, the protrusions and / or recesses are formed as concentric rings. In this profile, the protrusions and recesses extend radially from the inside out. In particular, this results in a uniform shift of stress in the axial direction at various locations.

[0040] The protrusions or depressions can, in particular, have a basic triangular cross-section. In this embodiment, the cross-section is formed as a sawtooth shape. However, other structures, such as wavy, especially sinusoidal, or nodules that are nested together, are also possible.

[0041] In one embodiment of the invention, the structural elements of the first material are formed in a tapered shape. The structural elements, such as tabs or nodules, taper upwards. This facilitates the provision of a second layer of structural elements via injection molding of the second material. In particular, it reduces the tendency for air bubbles to form in areas adjacent to the structural elements.

[0042] In one embodiment of the invention, a structural portion on the front side of the syringe base end wall includes at least one tab and / or groove extending at least partially from the nozzle in the sidewall direction. Thus, a torsional brake is provided. Elements of this structural portion can also be formed as nodules and / or wedges.

[0043] In one embodiment, the structural portion of the syringe base end wall may have at least one, preferably multiple, radially extending tabs and / or grooves. The tabs or grooves may have any cross-section. However, they are preferably formed in a serrated shape.

[0044] Due to their radial arrangement, the tabs and grooves form a shape-fitting connection, acting as a torsional brake.

[0045] In particular, in a top view, the structural section can have a fan-shaped and / or star-shaped design. For example, the fan-shaped members are formed by radially extending tabs, while the covering is formed by a cross-section extending in a ring-like manner between the tabs. The fan extends around the threaded joint, thus occupying a 360° end face.

[0046] The structure may have 3 to 16, preferably 6 to 10, radially extending and circumferentially distributed tabs and / or grooves.

[0047] The form-fitting connection provided by the structural components is particularly helpful in increasing the strength of the connection under torque pressure, such as when screwing the joint in forcefully.

[0048] In a further improvement of the invention, the second material layer is formed in a thickened manner around the threaded joint compared to the radially adjacent region of the second material layer. Therefore, the second layer is reinforced in the transition region from the threaded joint to the end wall through a thickened portion, such as a toroidal surface (Wulst) or an inner bevel. This reduces the risk of the threaded joint breaking when overtightened.

[0049] Furthermore, especially when a soft second material is used, the deformation of the material in the end-wall region is reduced during the fastening process, which in turn reduces the tendency for the bonded connection in that region to loosen.

[0050] The second preferred material is plastic, especially transparent plastic, which can be processed during injection molding.

[0051] The second material preferably has a higher notched impact toughness than the first material. In particular, the notched impact toughness of the second material is at least 20% higher than that of the first material, and preferably at least 50% higher.

[0052] Notched impact toughness is a material property that defines the tendency of a material to crack under dynamic loading. This notched impact toughness is determined in a notched bending impact test. Fracture occurs due to dynamic bending caused by sudden stress application, typically without the material flow observed during slow stress application. In the context of this invention, all material property values, particularly the notched impact toughness and the following material property values, were determined under standard conditions, i.e., 20°C and 50% humidity.

[0053] The notched impact toughness in this invention is determined according to DIN ISO 179-1 (11 / 2010). Here, a notched test specimen, standardized in shape, is loaded by an impact pendulum. The impact pendulum creates a notch on the test specimen or penetrates it with a defined kinetic energy. The notch is then measured, or, in the case of penetration, the height of the pendulum's return swing is recorded. The impact energy (Schlagarbeit) used can be calculated based on the weight of the impact pendulum and the difference between the starting and ending positions of the pendulum, where the impact energy represents the product of the sample cross-section and the notched impact toughness.

[0054] The notched impact toughness of cycloolefins is typically around 3 kJ / m. 2 The following. Conversely, the second material should possess higher notched impact toughness, particularly exceeding 3.5 kJ / m. 2 Preferably, it exceeds 5kJ / m 2 .

[0055] In particular, polypropylene can be used as a secondary material. Specifically, partially crystalline polypropylene has good mechanical properties and is also transparent.

[0056] The second material can be softer than the first material. In particular, the Shore hardness D of the second material (according to DIN ISO 7619-1 (2 / 2012)) can be less than 75, especially less than 70. Conversely, in one embodiment of the invention, the cycloolefin has a Shore hardness D exceeding 80.

[0057] In one embodiment of the invention, the elastic modulus of the second material is lower than that of the first material. In particular, the elastic modulus of the second material (according to DIN ISO 527-1(2 / 2019)) is between 1000 and 1800 MPa. The elastic modulus of cycloolefins can be particularly between 1800 and 2200 MPa.

[0058] In particular, elongation at break is also an important characteristic parameter of the second material. According to one embodiment of the invention, the elongation at break of the second material is at least 1.5 times higher than that of the first material, preferably at least 5 times higher, and particularly preferably at least 10 times higher. The elongation at break is also determined according to DIN ISO 527-1. The elongation at break is expressed as a percentage (%).

[0059] The elongation at break of the cyclic olefins used can be less than 5%, while the elongation at break of, for example, polypropylene can reach 100% or higher.

[0060] For a threaded joint to break, the material must deform beyond its yield strength. Trained users will typically notice the subsequent deformation of materials with high elongation at break in the plastic region, recognizing that the joint's load-bearing capacity has now been exceeded.

[0061] In one embodiment of the invention, the structural portion on the front side of the syringe base end wall is specifically defined by a radially surrounding tab. This structural portion terminates within the end wall of the syringe base. This tab can be formed, in particular, from the front portion of the side wall of the syringe base. Therefore, the highly transparent appearance of the side wall is fully preserved.

[0062] Therefore, it is specifically stipulated that the structure ends when it reaches the inner sidewall. In this embodiment, the sidewall thus reaches the leading edge of the syringe body, and the structure ends directly on the sidewall. Therefore, on the one hand, the entire endwall can be used to provide the structure. On the other hand, since the material transition is located exactly at the inner edge of the sidewall, it is almost invisible in the top view.

[0063] According to one embodiment, the maximum structural depth of the structural portion of the first and / or second material exceeds 0.1 mm, preferably exceeds 0.25 mm, and / or is less than 1 mm, preferably less than 0.5 mm. The maximum structural depth can be understood as the vertical difference between the top of the protrusion and the bottom of the recess. Therefore, this structural portion is on the order of macroscopic scale, thereby effectively achieving the aforementioned force deflection.

[0064] The distance from one convex point to another, or from one concave point to another, the so-called structural width, in one embodiment of the invention, is greater than 0.2 mm, preferably greater than 0.5 mm, and / or less than 3 mm, preferably less than 1.5 mm.

[0065] According to one embodiment of the present invention, the ratio of the maximum structural depth to the structural width may also be greater than 0.1, preferably greater than 0.25 and / or less than 1, preferably less than 0.5.

[0066] In one embodiment of the invention, the wall thickness of the first material layer in the end-wall region is 0.3 to 3 times, preferably 0.5 to 1.5 times, the wall thickness of the second material layer. The total wall thickness, particularly in the end-wall region formed at least partially in a two-layer configuration, can be, for example, between 0.3 mm and 5 mm, preferably between 0.6 mm and 2.5 mm.

[0067] Syringes including the syringe body according to one of the above embodiments are also within the scope of the present invention, wherein the syringe has a stopper for sealing the nozzle, a plunger, and, in particular, a plunger rod for discharging medical fluid through the nozzle. The plunger rod may be pre-installed on the plunger or provided separately.

[0068] The syringe according to the invention is preferably filled with a medical liquid, particularly a liquid containing a drug. In this case, the syringe is a pre-filled syringe.

[0069] In particular, the syringe is housed in a preferably oxygen-impermeable outer packaging, such as a tearable aluminum foil package. The syringe, preferably a packaged syringe, is especially autoclaved. The syringe is autoclaved in the outer packaging, for example at a temperature above 110°C, preferably above 120°C, and is therefore completely sterile.

[0070] According to one embodiment, the medical fluid is an oxygen-sensitive medical fluid, such as a medical emulsion. According to one embodiment, the pharmaceutical solution is or includes propofol, particularly a propofol emulsion. The chemical name of propofol is 2,6-diisopropylphenol (IUAPC).

[0071] According to another aspect, the invention relates to a syringe comprising a syringe body having a nozzle and a threaded connector, wherein the syringe body includes sidewalls and endwalls, wherein the syringe body at least partially comprises a cyclic olefin, particularly a cyclic olefin copolymer or cyclic olefin polymer, as a first material forming the inner wall of the syringe body, and the threaded connector at least partially comprises a second material, i.e., a material different from the cyclic olefin, wherein the first material and the second material are connected to each other in a material bond manner, and wherein the second material extends at least partially onto the first material in the endwall region, thereby forming the endwall at least partially in a two-layer manner, wherein the nozzle is formed of the first material and at least partially in a single-layer manner.

[0072] The syringe can have any combination of the above features. Specifically, the two-layered regions of the end wall can be formed by a syringe base with structural portions, wherein complementary structural portions of the connector provide mutually nested engagement. Since the nozzle is at least partially not covered by the second material, contact between the second material and the medical fluid is avoided during intended use. It has been found that, despite this, a sufficient mechanical connection can still be achieved between the first and second materials, particularly through injection molding processes. This is especially ensured by the aforementioned structural portions.

[0073] The present invention further relates to a method for manufacturing a syringe body.

[0074] The method includes the following steps:

[0075] A syringe matrix is ​​injection molded using a cycloolefin as the first material, wherein a recessed structural portion is formed in the end wall of the syringe matrix.

[0076] A connector with a threaded joint, made of a second material, is injection molded onto the end wall of a syringe base. The recess of the structural portion is filled with the second material, so that the structural portion on the front side of the syringe base end wall and the complementary structural portion formed on the rear side of the connector are nested and joined together.

[0077] Here, an injection molding die is used, the injection molding die including a negative mold for the end wall structure of the syringe body, thereby forming a syringe base having a structured end wall.

[0078] Then, a connector with a threaded joint is injection molded onto the end wall using a second material. The connector forms a complementary structure in the structured end wall region of the syringe body, which, as described above, greatly improves the mechanical connection between the two materials. Attached Figure Description

[0079] The following will be based on Figures 1 to 10 Based on this, the subject matter of the present invention will be explained in more detail with reference to exemplary embodiments.

[0080] Figure 1 This is an axial sectional view of a syringe according to a first embodiment of the present invention.

[0081] Figure 2 An alternative embodiment of the syringe is shown.

[0082] Figure 3 It is a three-dimensional view of the head component of a syringe or syringe body.

[0083] Figure 4 It is a perspective view of the head component of the syringe base or syringe body without any attached connectors.

[0084] Figure 5 It is a 3D image where the connectors are shown as a transparent grid.

[0085] Figure 6 It is along Figure 5 A sectional view of line B.

[0086] Figure 7 It is along Figure 5 A sectional view of line C.

[0087] Figure 8 and Figure 9 This is a schematic diagram of an alternative structural component.

[0088] Figure 10 This is a flowchart of method steps according to an embodiment of the method of the present invention. Detailed Implementation

[0089] Figure 1 An embodiment of the syringe 1 according to the invention is shown in an axial sectional view, wherein only the syringe body 2 is shown in the view, and the plunger and plunger rod are not shown.

[0090] This invention is applicable to syringes of almost any volume, particularly syringes from 1 ml to 100 ml.

[0091] According to Figure 1 In one implementation, a relatively large syringe 1 is shown, particularly its internal volume 3, which is approximately 50 ml.

[0092] The syringe 1 includes a nozzle 101, which is preferably tapered. A threaded connector 201 with internal threads extends around the nozzle 101. In particular, the threaded connector is a male Luer lock connector.

[0093] As can be seen from this cross-sectional view, there is a two-layer structure of two materials in the end wall 4 region of the syringe body 2 (see also...). Figure 3 and 4 In the illustrated embodiment, the sidewalls of the syringe substrate are also formed in two layers and covered by a second material.

[0094] The syringe body 2 includes a syringe base 100, which includes a nozzle 101 and a connector 200. The connector includes a threaded joint 201.

[0095] The sidewalls 102 of the syringe matrix 100 are formed of a first material. The first material is provided by a cycloolefin. The second material is also transparent.

[0096] Figure 2This is an axial sectional view of another embodiment of syringe 1. This embodiment involves a relatively small syringe, specifically its internal volume 3 is approximately 5 ml. However, the basic structure of the syringe body 2 remains unchanged. The dimensions of the connector, consisting of nozzle 101 and threaded fitting 201, are consistent with... Figure 2 The embodiments are no different. Therefore, the diameter of the threaded connector 201 is significantly larger than the maximum diameter of the syringe body 2.

[0097] Figure 3 The head component of a syringe 1 according to another embodiment of the present invention is shown in a perspective view.

[0098] The syringe body 2 comprises a syringe base 100 and a connector 200, the connector preferably being injection molded onto the syringe body 100. The connector 200 is formed of a material different from the syringe base 100. The connector 200 is formed of a second material. The second material is a material different from the first material, such as polypropylene.

[0099] The connector 200 includes an end wall 202 that extends to the side wall 102 of the syringe body 100. A threaded connector 201 extends around a nozzle 101, which is part of the syringe body 100 and is therefore also formed of a first material, namely a cycloolefin.

[0100] Figure 4 Only the syringe matrix 100 made of cyclic olefins is shown in a corresponding perspective view. The end wall 103 of the syringe matrix 100 includes a structural portion 104, which is preferably provided by injection molding.

[0101] In this embodiment, the structural portion 104 of the end wall 103 includes a plurality of rings 105a-105n extending concentrically around the nozzle 101, which are formed as protrusions here.

[0102] These rings 105a-105n are interrupted by a plurality of radially extending grooves 106, which cooperate with the injection-molded connectors 200 to form a torsion brake.

[0103] Figure 5 It is a 3D view, in which connector 200 is now shown as a transparent mesh.

[0104] In this view, two layers of the end wall of the syringe body 2 are shown, which are formed by the cyclic olefin of the syringe matrix 100 and the layer of the connector 200, which is made of a second material (particularly polypropylene) disposed thereon.

[0105] The two-layer region has a structure that is nested and joined to each other, which is formed by a structure 104 of a first material and a structure 208 of a second material nested and joined to it.

[0106] Therefore, especially in Figure 6 along Figure 5 As shown in the detailed representation of section line B, the mutually nested and joined structural portions formed according to the present invention are formed by structural portion 104 of syringe base 100 and structural portion 208 of connector 200 that is nested and joined with structural portion 104.

[0107] In a radial sectional view, the structural portion 104 of the syringe body 100 includes a plurality of teeth 105a-105n. In this embodiment, the structural portion 104 is formed in a serrated shape in the axial section. Corresponding teeth formed from the second material of the connector 200 engage between the teeth 105a-105n.

[0108] The second material extends to the edge 109 of the syringe body 2, so that the entire sidewall 102 of the syringe body 2 is formed of cyclic olefins.

[0109] In this embodiment, the structural portions of the syringe base 100 and the connectors 104 / 208 are both formed as regular structural portions, wherein the distance between peaks or valleys is determined by the distance 'a' between two peaks or two valleys. The peaks and valleys are also referred to as protrusions or depressions.

[0110] Furthermore, structural section 104 / 208 has a maximum depth t, which is defined by the vertical distance between the top of the protrusion and the bottom of the recess.

[0111] The threaded connector 201, with internally threaded teeth 203, opposite to the nozzle 101, transitions to the end wall 202 of the connector 200 via an annular surface 205 in the second material region. This increases the mechanical strength of the region, thereby reducing the risk of breakage of the threaded connector 201.

[0112] Inside the threaded connector 201, the base 207 of the threaded connector 203 reaches an inner angle 107, at which the end wall 103 of the syringe base 100 transitions to the nozzle 101. Therefore, the nozzle 101 is not covered by a second material. Consequently, the material of the connector 200 will not come into contact with medical fluids during intended use.

[0113] Figure 7 It is along Figure 5The cross-sectional view is shown by line C. This cross-section now extends through a radial groove 106 in the syringe base 100. The groove 106 is formed such that the teeth or rings 105a-105m of the structural portion 104 are interrupted in a radially extending strip. A corresponding tab 209 made of a second material is constructed in the groove 106. This tab mates with the groove 106 to form a torsional brake.

[0114] In this embodiment, the ring 105n, which directly reaches the threaded joint 201, is not slotted by the groove 106. In the region of the tab 209, this ring also forms a deflection point, through which stress introduction into the region of the tab 209 can be reduced.

[0115] The syringe base 100 also has an annular surface 108 on its edge side. The upper side 206 of the connector 200 or the end wall 4 of the syringe base 2 is aligned with the upper edge 109 of the side wall 102.

[0116] Figure 8 and Figure 9 An alternative embodiment of the structure is shown in a schematic top view of the end wall 4 of the syringe body 2.

[0117] according to Figure 8 In the embodiment shown, the syringe base 100 includes a structural portion 104 composed of a plurality of protruding nodules evenly distributed in two layers. The structural portion 104 is filled with a second material of the connector 200, thus forming a form-fitting connection between the syringe base 100 and the connector 200. A complementary design with recesses is also possible. Here, these nodules would be formed from the second material of the connector 200.

[0118] according to Figure 9 In the illustrated embodiment, structural portion 104 includes triangles that act as protrusions or recesses, with their tips pointing radially toward the midpoint.

[0119] Figure 10 This is a flowchart of method steps according to an embodiment of the method of the present invention.

[0120] First, a syringe base 100 with a nozzle 101 is injection molded using a cycloolefin. An injection molding tool is used here, which is formed such that the end wall 103 of the syringe base 100 includes a structural portion 104.

[0121] Then, a connector 200 with a threaded joint 201 is injection molded onto the syringe matrix 100 using a second material (especially polypropylene).

[0122] The syringe body 2, now composed of two different materials, is characterized by high connection strength, wherein the entire inner wall of the syringe body 2 is formed of cyclic olefins.

[0123] List of reference numerals

[0124] 1. Syringe

[0125] 2. Syringe body

[0126] 3. Internal volume

[0127] 4 end wall

[0128] 100 Syringe Base

[0129] 101 Nozzle

[0130] 102 Sidewall

[0131] 103 end wall

[0132] 104 Structural components of the syringe base

[0133] 105a-105n ring / tooth

[0134] 106 radial grooves

[0135] 107 jiao

[0136] 108 Torus

[0137] 109 Edge

[0138] 200 connectors

[0139] 201 Threaded Connector

[0140] 202 end wall

[0141] 203 teeth

[0142] 205 Torus

[0143] 206 upper side

[0144] 207 Base

[0145] 208 Structural parts of the connector

[0146] 209 stitched images

Claims

1. A syringe body (2) for a syringe (1), the syringe body comprising a syringe base (100) having a sidewall (102), an endwall (103), and a nozzle (101) disposed on the front side of the endwall (103), in, The syringe matrix (100) at least partially comprises a cyclic olefin as a first material, which forms at least one inner wall of the syringe matrix (100). The connector (200) with a threaded joint is disposed on the rear side of the front side of the end wall (103) of the syringe base, and the connector (200) at least partially comprises a second material, which is a material different from the first material. The syringe base (100) and the connector (200) are connected by a material combination to form the syringe body (2). The invention is characterized in that the structural portion (104) on the front side of the end wall (103) of the syringe base (100) and the complementary structural portion (208) on the rear side of the connector (200) are nested together, wherein the structural portion (104) is formed as a height profile with a plurality of protrusions and recesses.

2. The syringe body (2) according to the preceding claim, characterized in that, The connector (200) is provided as a separate component that is mounted on the syringe base.

3. The syringe body (2) according to claim 1, characterized in that, The connector (200) is injection molded onto the syringe base (100).

4. The syringe body (2) according to any one of the preceding claims, characterized in that, The front side of the end wall (103) of the syringe base (100) and the rear side of the connector (200) are connected to each other in a material-bonded manner.

5. The syringe body (2) according to any one of claims 1 to 3, characterized in that, The cyclic olefin is at least one polymer selected from the group consisting of cyclic olefin copolymers, cyclic olefin polymers and highly transparent polymers.

6. The syringe body (2) according to any one of claims 1 to 3, characterized in that, The front part (104) of the end wall (103) of the syringe base (100) has at least one tab (209) and / or groove (106) extending at least partially from the nozzle (101) in the direction of the side wall (102).

7. The syringe body (2) according to any one of claims 1 to 3, characterized in that, The front part (104) of the end wall (103) of the syringe base (100) is at least partially shaped into a fan or star shape.

8. The syringe body (2) according to any one of claims 1 to 3, characterized in that, Compared to the radially adjacent region made of the second material layer, a layer made of the second material is formed in a thickened manner around the threaded joint.

9. The syringe body (2) according to any one of claims 1 to 3, characterized in that, The front part of the end wall (103) of the syringe base (100) is defined by a radially surrounding tab.

10. The syringe body (2) according to any one of claims 1 to 3, characterized in that, The second material is softer than the first material.

11. The syringe body (2) according to any one of claims 1 to 3, characterized in that, The ratio of structural depth to structural width exceeds 0.1 and / or is less than 1.

12. The syringe body (2) according to claim 11, characterized in that, The ratio of structural depth to structural width exceeds 0.25 and / or is less than 0.

5.

13. A syringe (1) comprising a syringe body (2) according to any one of the preceding claims, wherein, The syringe (1) has a stopper for sealing the nozzle (101), a plunger, and a plunger rod for discharging medical liquid through the nozzle (101).

14. The syringe according to claim 13, characterized in that, The syringe (1) is packaged in an oxygen-impermeable outer packaging.

15. The syringe according to claim 14, characterized in that, The syringe (1) is packaged together with the oxygen absorbent in an oxygen-impermeable outer packaging.

16. A method for manufacturing a syringe body (2) for a syringe (1) according to any one of claims 1 to 12, comprising the following steps: A syringe matrix (100) is injection molded from a cycloolefin as the first material, wherein a recessed structural portion (104) is formed on the end wall (103) of the syringe matrix (100). A connector (200) with a threaded joint (201) is injection molded on the end wall (103) by a second material, wherein the recess of the structure (104) is filled with the second material, so that the structure (104) on the front side of the end wall (103) of the syringe base (100) and the complementary structure (208) formed on the rear side of the connector (200) are nested together.

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