Optical detection slide and applicable detection processing method

Abstract

The present application discloses a light detection carrier and a detection and processing method applicable thereto. The light detection carrier comprises: a substrate layer, which transmits or reflects terahertz waves; a metal pattern layer located on the surface of the substrate layer, which forms a reference signal wave with polarization cancellation under the irradiation of the terahertz wave. The light detection carrier is used to carry the sample to be tested; the metal pattern layer comprises a plurality of resonator units, each of which is composed of a plurality of metal resonators of a non-closed shape, wherein the opening of the metal resonator rotates in a clockwise / counterclockwise direction to complete a cycle. During the irradiation of the terahertz wave, the light detection carrier carrying the sample transmits or reflects an absorption signal wave with polarization cancellation, and the absorption signal wave is formed after the terahertz wave passes through the sample and absorbs energy. The present application eliminates the polarization-related properties of the terahertz wave during the sample detection process. This feature effectively enhances the ease of detection during the sample detection process and reduces the volatility of the signal wave.

Description

Technical Field

[0001] The present application relates to the field of light detection technology, and in particular to a light detection slide and a detection and processing method applicable thereto. Background Art

[0002] During the distribution of drugs and their materials, including sales and scientific research, users must ensure the correctness of drug ingredients. To this end, qualitative component testing is required during the drug distribution process. For Traditional Chinese Medicine (TCM) drugs and their materials, due to the numerous and complex active ingredients naturally present in plants, testing requires the extraction of these ingredients, followed by testing of the extracted samples using testing equipment to confirm the active ingredients in the drug. This makes the component testing process in TCM very time-consuming. Summary of the Invention

[0003] In view of the shortcomings of the above-mentioned related technologies, the purpose of this application is to provide a light detection carrier to overcome the technical problems of the above-mentioned related technologies such as long drug detection operation process and complex detection operation.

[0004] To achieve the above-mentioned purpose and other related purposes, the first aspect disclosed in the present application provides a light detection carrier, which includes: a substrate layer, which transmits or reflects terahertz waves; a metal pattern layer located on the surface of the substrate layer, which forms a reference signal wave with polarization offset under the irradiation of the terahertz wave, wherein the metal pattern layer includes a plurality of resonator units, each resonator unit is composed of a plurality of metal resonators of a non-closed shape, wherein the opening of the metal resonator rotates in a clockwise / counterclockwise direction for one cycle; and a carrier for carrying a sample to be tested; wherein, during the irradiation of the terahertz wave, the light detection carrier carrying the sample transmits or reflects an absorption signal wave with polarization offset, and the absorption signal wave is formed after the terahertz wave passes through the sample and absorbs energy.

[0005] In certain embodiments of the first aspect, the metal pattern layer arranges at least one resonator unit; the resonator unit includes: a plurality of metal resonators; each metal resonator is obtained based on the periodic cyclic rotation of the same non-closed shape.

[0006] In certain embodiments of the first aspect, the non-enclosed shape comprises a basic geometric figure having an opening.

[0007] In certain embodiments of the first aspect, the size of the opening and the outer dimensions of the metal resonator are related to the frequency range of the terahertz wave.

[0008] In certain embodiments of the first aspect, the dimensions of the metal resonator are related to a frequency range of the terahertz wave.

[0009] In certain embodiments of the first aspect, the metal resonator is in the shape of a non-closed ring.

[0010] In certain embodiments of the first aspect, at least one of an outer ring diameter and an inner ring diameter of the metal resonator is related to a frequency band range of a terahertz wave.

[0011] In certain embodiments of the first aspect, the light detection carrier provides detection of samples arranged through multiple quantitative accumulations; wherein, during the terahertz wave detection of the samples corresponding to each quantitative accumulation, the light detection carrier carrying the corresponding accumulated samples transmits or reflects multiple absorption signal waves.

[0012] In summary, the present application utilizes a light detection carrier with a metal pattern layer to eliminate the polarization-related properties in the terahertz wave sample detection process. This feature effectively enhances the ease of detection during sample detection and reduces the volatility of the signal wave. In addition, since the sample is directly distributed on the light detection carrier, only a trace amount of sample powder is required for component detection, which is far less than the amount of sample required for detecting the sample using a tablet pressing method. Furthermore, by using terahertz waves to perform component detection on the sample, since the influence of polarized light is effectively reduced, more accurate spectral characteristics can be obtained, effectively improving the sensitivity of the terahertz wave detection equipment. In addition, by using multiple quantitative dripping and drying methods to evenly distribute the sample, the terahertz wave detection equipment can perform multi-signal detection on each absorption signal wave corresponding to the varying density, thereby obtaining more accurate component information; at the same time, the above operation avoids manual error and improves detection efficiency.

[0013] Those skilled in the art can easily discern other aspects and advantages of the present application from the detailed description below. In the detailed description below, only exemplary embodiments of the present application are shown and described. As will be appreciated by those skilled in the art, the content of this application enables those skilled in the art to modify the disclosed specific embodiments without departing from the spirit and scope of the invention to which this application relates. Accordingly, the descriptions in the drawings and specification of this application are merely exemplary and not restrictive. BRIEF DESCRIPTION OF THE DRAWINGS

[0014] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the following briefly introduces the drawings required for use in the embodiments. It should be understood that the following drawings only illustrate certain embodiments of the present invention and therefore should not be regarded as limiting the scope. For ordinary technicians in this field, other relevant drawings can be obtained based on these drawings without paying any creative work.

[0015] Figure 1 Shown is a schematic structural diagram of the light detection slide.

[0016] Figure 2Schematic diagram showing the structure of a resonator unit consisting of four metal resonators.

[0017] Figure 3 Shown is another structural schematic diagram of a resonator unit.

[0018] Figure 4 Shown is a schematic diagram of the structure of a terahertz wave detection device.

[0019] Figure 5 A flow chart showing a detection processing method executed by an electronic device is shown.

[0020] Figure 6 Schematic diagram of the waveform showing the peaks in the reference spectrum data and the peaks in the absorption spectrum data. DETAILED DESCRIPTION

[0021] The following describes the implementation of the present application through specific embodiments. People familiar with this technology can easily understand other advantages and effects of the present application from the contents disclosed in this specification.

[0022] In the following description, reference is made to the accompanying drawings, which describe several embodiments of the present application. It should be understood that other embodiments may also be used, and that changes in module or unit composition, electrical, and operational aspects may be made without departing from the spirit and scope of the present disclosure. The following detailed description should not be considered restrictive, and the scope of the embodiments of the present application is limited only by the claims of the published patents. The terms used herein are only for the purpose of describing specific embodiments and are not intended to limit the present application.

[0023] Although in some instances the terms first, second, etc. are used to describe various elements, information or parameters in this article, these elements or parameters should not be limited by these terms. These terms are only used to distinguish one element or parameter from another element or parameter. For example, the first variation rule can be referred to as the second variation rule, and similarly, the second variation rule can be referred to as the first variation rule, without departing from the scope of the various described embodiments. The first variation rule and the second variation rule are both describing a variation rule, but unless the context clearly indicates otherwise, they are not the same variation rule. Depending on the context, the word "if" such as used herein can be interpreted as "at the time of..." or "when...".

[0024] Furthermore, as used herein, the singular forms "a", "an", and "the" are intended to include the plural forms as well, unless the context indicates otherwise. It should be further understood that the terms "comprise", "include" indicate the presence of the described features, steps, operations, elements, components, items, kinds, and / or groups, but do not exclude the presence, occurrence, or addition of one or more other features, steps, operations, elements, components, items, kinds, and / or groups. The terms "or" and "and / or" used herein are interpreted as inclusive, or mean any one or any combination. Thus, "A, B, or C" or "A, B, and / or C" means "any of the following: A; B; C; A and B; A and C; B and C; A, B, and C". Exceptions to this definition occur only when the combination of elements, functions, steps, or operations is inherently mutually exclusive in some way.

[0025] The term "uniform" used in this article does not refer to the quantified density of a substance within a unit space; rather, it refers to the dispersed state achieved by dispersing, covering, or laying out the substance with the goal of determining its composition, under the premise that the experiment is feasible.

[0026] In addition, the boundary data of the test range mentioned in this article is not limited to integer levels, but should also include higher precision ranges determined based on tolerable errors, such as ±0.1, ±0.01, etc.

[0027] For traditional Chinese medicine, since its raw materials are taken from plants, and the appearances of different plants are similar, it is difficult to determine whether the ingredients of traditional Chinese medicine correspond to the predicted plants through a one-time test. For example, ginseng, American ginseng and Panax notoginseng, because they belong to the same plant attribute category, have similar plant characteristics, such as the shape, color, smell, etc. of leaves and stems, but have different medicinal ingredients (referred to as ingredients). Therefore, the ingredient information of its medicine cannot be determined based solely on plant characteristics. Among them, the ingredient information includes information on medicinal plants such as traditional Chinese medicine, and / or information on natural effective extracts as medicines in the medicinal plant information. Examples of natural effective extracts include ginsenosides in ginseng.

[0028] Taking traditional Chinese medicine samples as an example, the drug samples sent for inspection are usually in the physical form of powder, fragments, etc. In order to detect the component information in the drug samples sent for inspection, in some examples, technicians need to use the physical properties of possible components in the drug samples, such as density, polarity, solubility, etc., to separate them to extract a purified solution with a certain concentration, and perform microscopic imaging detection on the purified solution to identify the cells of biological macromolecules in the purified solution, so as to obtain the component information of the corresponding drug sample. When the composition of the drug sample being tested is uncertain, technicians need to perform multiple separations and spectral detections. This requires sufficient samples to obtain accurate conclusions, and the entire detection operation is highly complex, and the time for one inspection is about one week.

[0029] To improve the efficiency of component detection in drug samples, some researchers have used microscopic imaging to identify components by dropping multiple purified solutions onto separate optical detection slides (also called optical detection devices or detection chips) to increase detection throughput. However, this approach has not substantially reduced the complexity of the detection operation.

[0030] In order to effectively reduce the complexity of the detection operation and improve the detection efficiency, in some other examples, technicians mix the sample to be tested with the auxiliary material (such as polyethylene powder) according to a preset weight ratio, and press it into a tablet to be tested; clamp the tablet to be tested on the detection frame; use an optical detection instrument to perform spectral analysis on the sample in the tablet to determine the corresponding composition information. However, the sample in the tablet is detected within a preset terahertz frequency band. Due to the generation of random polarization waves during the propagation of light waves, the absorbed light transmitted or reflected by the tablet contains polarization light signals. As a result, the characteristic spectrum reflecting the composition information in the absorbed light is not obvious.

[0031] Based on the above-mentioned method for detecting powdered drug samples, this method can be extended to other trace detection methods, such as those for samples such as powdered hazardous materials and drug substances. To improve detection accuracy while simplifying the detection operation, this application provides a light detection carrier capable of detecting samples. The light detection carrier is used to carry the sample to be tested, which is evenly distributed on its surface, and is placed together with the sample in a terahertz wave detection device to suppress the interference of polarized waves in the effective frequency band of light on the absorption signal wave after it acts on the sample.

[0032] Here, since the signal wave in the terahertz band can act on the characteristics of most biological macromolecules in the medicine, the light detection carrier is a carrier used to offset the polarized light in the terahertz band, and transmit or reflect the absorption signal wave after the energy is absorbed by the medicine sample. Among them, the signal wave in the terahertz band is an electromagnetic wave with a frequency ranging from 0.1THz to 10THz and a wavelength ranging from 0.03 to 3mm. The components in different medicine samples have different responses to the frequency band of the terahertz wave. Therefore, the structure of the light detection carrier is related to the frequency band of the terahertz wave corresponding to the medicine sample to be tested. In order to use the light detection carrier of the same structure to detect the component information of multiple medicine samples, the light detection carrier is selected in advance according to the frequency band of the terahertz wave and at least one medicine sample that can be detected. Among them, the medicine samples that can be detected are determined according to the medicine range provided in the "Chinese Pharmacopoeia". For example, the same terahertz band can correspond to medicines such as ginseng, American ginseng and Panax notoginseng. When testing at least one of these three components in the drug sample to be tested, a light detection carrier can be selected and combined with the corresponding terahertz wave frequency band to detect at least one component.

[0033] See also Figure 1 , which is a schematic structural diagram of the light detection carrier. The light detection carrier comprises a substrate layer 10 and a metal pattern layer 11. The light detection carrier can be clamped on a detection frame or placed on a hollow structure detection table.

[0034] The substrate layer is made of a material that transmits or reflects terahertz waves. For example, it can be made of polyimide, silicon dioxide, or quartz, materials with good terahertz wave transmission or reflection capabilities. Materials with different dielectric constants and the thickness of the resulting substrate layers exhibit different responses at different terahertz wave frequencies. The terahertz wave band is designed to allow the sample to absorb energy in a specific band, causing the substrate layer to transmit or reflect the absorbed signal wave.

[0035] The metal pattern layer is located on the surface of the substrate layer and generates a polarization-offset reference signal wave under terahertz wave irradiation.

[0036] In some examples, the surface of the substrate layer is arranged with assembly grooves of a preset pattern, and a metal structure with a corresponding pattern matches the assembly grooves, so that the surface of the metal structure forms a metal pattern layer on the surface of the substrate layer.

[0037] In order to avoid liquid leakage caused by the sample dripping onto the light detection slide in the form of droplets, in other examples, the light detection slide is a slide made based on the chip preparation method. Specifically, the metal pattern layer is a metal film structure manufactured on the surface of the substrate using chip manufacturing technology. Examples of the metal material include copper, gold, etc. The pattern formed by the metal film structure makes the various signal waves transmitted or reflected by the terahertz wave through the metal pattern layer and the substrate layer polarization-independent. In particular, by using a metal film with a pattern on the metal pattern layer, each unit pattern of the metal pattern layer generates polarization under the action of the terahertz wave, and the directions are different. By using the overall design of the metal layer, the resonances in multiple directions cancel each other out. This makes the various signal waves transmitted or reflected polarization-independent. In particular, the polarization cancellation includes weakening the polarization or completely canceling the polarization.

[0038] The above-mentioned unit patterns can be inconsistent, so as to offset the polarization by utilizing the multi-directional resonance formed by the metal film with inconsistent patterns. The metal film of each unit pattern is also called a metal resonator. The metal pattern layer includes a plurality of resonator units, each of which is composed of a plurality of metal resonators of a non-closed shape, wherein the opening of the metal resonator rotates in a clockwise / counterclockwise direction to complete a cycle. For example, the shapes of the metal resonators are different, and under the irradiation of the terahertz wave, they form enhanced electric fields with different directions from each other; by utilizing the periodic relationship of the cyclic rotation of each opening, each enhanced electric field as a whole offsets the polarization effect in the terahertz wave, thereby achieving polarization independence of each signal wave transmitted or reflected by the substrate layer.

[0039] Examples of the non-closed shape of the metal resonator include basic geometric shapes with openings, wherein the basic geometric shapes include line segments, broken lines, arcs, etc.

[0040] The metal pattern layer is provided with at least one resonator unit. The resonator unit is a combination of at least two metal resonators that are made according to a preset pattern and are spaced apart from each other; the resonator unit acts as a device that can offset the polarization of the terahertz wave received by the resonator unit area. At least one resonator unit is arranged on the metal pattern layer so that the entire effective contact surface of the light detection carrier receiving the terahertz wave has polarization cancellation capability. Among them, each resonator unit presents characteristics distributed on the substrate layer based on the rotation and offset of a single resonator unit to form a metal pattern layer. To facilitate manufacturing, the shape of the metal resonator includes a pattern with an opening including a non-closed loop.

[0041] To enhance the polarization cancellation effect of the optical detection slide on terahertz waves, at least one of the size of the metal resonators in the metal pattern layer, the spacing range between adjacent metal resonators, the spacing range between resonator units, and the area ratio of the resonator units to the substrate layer are related to the terahertz wave band. The terahertz wave band is designed for the sample to absorb energy in a specific wavelength range, making the absorption signal wave transmitted or reflected after polarization cancellation by the metal pattern layer polarization-independent.

[0042] In some examples, the contour shape of each metal resonator in the resonator unit is obtained by rotating a non-closed shape. Examples of the non-closed shape include a line segment, a broken line, or a ring with an opening. Examples of the ring include any one of the following: a circular ring, an elliptical circular ring, or an N-sided ring, where N is greater than or equal to 3. For example, the contour shape of the metal resonator is a triangular ring with an opening on one side. For another example, the contour shape of the metal resonator is a right-angled broken line shape. In order to make the metal resonator produce enhanced resonance in a preset direction under the action of terahertz waves, the ring shape is a ring shape with an opening or an arc-shaped ring, such as a C-shaped shape.

[0043] In the metal resonator structure provided in the above example, the metal resonator uses a metal film of uniform width to form a corresponding non-enclosed shape. The width of the metal resonator and / or the size of the opening are related to the frequency band of the terahertz wave. For example, the size of the opening is related to the wavelength range of the terahertz wave band. For example, if the terahertz wave frequency range is between [1, 3] THz, the corresponding opening size is between [3, 4] μm.

[0044] The multiple metal resonators in the resonator unit as a whole offset the polarization of multiple main directions orthogonal and / or multiple main directions opposite. In a specific example, the metal resonators in the resonator unit are arranged according to a cyclic rotation rule, so that the direction of the resonance enhancement generated based on each opening direction offsets the polarization of the terahertz wave as a whole. The metal resonators in the resonator unit are rotated and arranged with the same or different angles with a cycle of 360 degrees, so that the rotated metal resonators as a whole offset the polarization properties of the terahertz wave.

[0045] See also Figure 2 , which shows a schematic diagram of the structure of a resonator unit composed of four metal resonators, each of which is a circular ring with an opening, and the metal resonators are arranged in a centrosymmetrical structure according to the clockwise rotation direction. The clockwise rotation direction is only an example.

[0046] In another specific example, the metal resonators in the resonator unit together form a non-closed, center-symmetrical ring structure, wherein the opening formed in the non-closed portion of the ring structure is center-symmetrical. Figure 3 , which shows another structural schematic diagram of the resonator unit. The metal resonator is in the shape of a broken line with an angle of 60°. The three metal resonators in the resonator unit are a centrally symmetrical non-closed equilateral triangular ring formed by rotation; the non-closed part formed by the interval between the two metal resonators is also centrally symmetrical.

[0047] It should be noted that the above examples are only examples, and the non-closed shapes based on central symmetry can also be exemplified by pentagonal rings, hexagonal rings, etc. The sizes of the metal resonators based on central symmetry can be selected according to the frequency range of the terahertz wave, including the opening size and / or the outer size. Figure 2 For example, the shape shown in the figure shows a metal resonator suitable for terahertz waves in the frequency range [1, 3] THz. Its aperture size is in the range [3, 4] μm, its inner diameter is in the range [9, 11] μm, its outer diameter is in the range [19, 21] μm, and its linewidth is in the range [4.5, 5.5] μm. The resulting resonator unit within this size range has the same equivalent inductance and capacitance at different powers and different terahertz polarizations.

[0048] When not carrying a sample, the metal pattern layer and substrate layer generate a polarization-canceled reference signal wave under terahertz wave irradiation. This reference signal wave reflects the signal wave generated by the material of the light detection carrier under the influence of the terahertz wave. To prevent the light detection carrier itself from affecting the absorption signal wave generated by the sample after terahertz wave absorption during sample detection, the reference signal wave serves as a reference signal for the absorption signal wave.

[0049] The metal pattern layer is used to carry the distributed samples to be tested. During the terahertz wave irradiation, the metal pattern layer and the substrate layer transmit or reflect the absorption signal wave with polarization offset, and the absorption signal wave is formed after the terahertz wave passes through the sample and absorbs energy.

[0050] The sample is an object consumed in appropriate quantities for optical detection; it can be a liquid sample. This includes a liquid sample, a sample dissolved in a solvent, or a sample suspended in a solution with a density similar to the sample. To reduce the frequency bands of light energy absorbed by the terahertz wave by the component to be detected and irrelevant components in the liquid sample, which can lead to large detection errors, the sample is a powdered sample.

[0051] Different samples absorb energy in different frequency bands of the terahertz wave, causing the corresponding frequency bands of the transmitted or reflected terahertz wave to change, generating signal characteristics (also known as absorption signatures). The signal waves transmitted through the optical detection slide and sample, carrying the absorption signature, can be detected by the corresponding terahertz detection equipment, and signal analysis can provide compositional information. Similar to the reference signal wave, due to the polarization cancellation operation of the metal pattern layer, the absorption signal wave is also polarization-independent with respect to the terahertz wave.

[0052] In some examples, the powdered sample can be pressed into a tablet as described above. In other examples, considering that the density of the powdered sample in the tablet is a fixed value, in order to detect multiple component information based on different densities, multiple tablets with different densities need to be made, which results in a large number of repetitive manual detection operations and is prone to errors. In order to be able to more conveniently adjust the density of the powdered sample so as to detect the absorption characteristics of different components, the powdered sample can be accumulated and evenly arranged on the metal pattern layer multiple times. In other words, the powdered sample is not mixed in the auxiliary material in the form of a tablet, but is evenly and dispersed on the surface of the metal pattern layer. In this way, the metal pattern layer and the powdered sample that has been accumulated and evenly arranged multiple times, when receiving terahertz waves, transmit or reflect multiple absorption signal waves. The absorption characteristics in each absorption signal wave are related to the density of the arranged powdered sample and the absorption characteristics caused by the gradually increasing density.

[0053] In some specific examples, the powdered sample is sprayed onto the light detection slide to form a uniformly distributed sample to be detected.

[0054] In other specific examples, the powdered sample is uniformly mixed with a solution. The solution is a substance that, based on physical properties such as density or physical compatibility, uniformly distributes the powdered sample to be tested. Examples of the uniform distribution include a state formed by dissolution through a physical reaction, or a suspended state formed due to the similar density of the solution and the powdered sample. The physical reaction refers to a process of molecular diffusion, energy equilibrium, or density equilibrium. The light detection slide carries a liquid mixed with the powdered sample. To prevent components in the solution from absorbing / releasing energy due to the terahertz wave, causing the absorption signal wave transmitted or reflected by the light detection slide to be mixed with characteristic information of the components in the solution, the solution must be removed before detection. In this case, the solution is a volatile liquid, such as ethanol or water. When the liquid mixed with the powdered sample is dropped onto the light detection slide, the powdered sample is evenly distributed on the light detection slide after the solution evaporates.

[0055] The use of a volatile solution can also help change the density of the powdered sample to be tested. For example, by repeatedly and quantitatively dropping a liquid containing a mixed powdered sample onto the same light detection slide, the density of the powdered sample to be tested can be gradually increased.

[0056] As the density of the powdered sample placed on the light detection slide increases, the resulting absorption characteristics also change. For example, as the density of the powdered sample placed on the light detection slide increases, the absorption characteristics in the absorption signal wave become stronger. In another example, as the density of the powdered sample placed on the light detection slide increases, the absorption characteristics in the absorption signal wave change from being undetectable to being detectable.

[0057] By utilizing the polarization offset of the metal pattern layer of the above-mentioned light detection carrier and the function of the substrate layer to transmit or reflect terahertz waves, the light detection carrier, in a terahertz wave environment, can achieve a polarization-independent effect for the transmitted or reflected signal waves regardless of whether the intensity of the terahertz wave changes.

[0058] The present application also provides a terahertz wave detection device, wherein the terahertz wave detection device utilizes the absorption of terahertz waves by the sample to be tested to detect the composition of the sample.

[0059] See also Figure 4 , which is a schematic diagram of the structure of the terahertz wave detection device provided by the present application. The terahertz wave detection device 2 includes a loading mechanism 21, a terahertz wave generator 22, and a detection processing device 23.

[0060] The object-carrying mechanism is used to assemble the light detection slide. Among them, the light detection slide is exemplified by the above Figure 1-Figure 3 The light detection carrier provided in each example thereof, or other light detection carrier whose composition information can be detected by the terahertz wave detection device.

[0061] In some examples, the carrier mechanism includes a clamping portion with at least one movable end. The clamping portion is used to clamp the edge of the light detection slide on which the sample is distributed. For example, the clamping portion includes a movable end and a fixed end, and the movable end and the fixed end form a hollow structure. The light detection slide passes through the elastic edge of the movable end, and the clamp is between the movable end and the fixed end to fix the evenly distributed sample in the hollow area. The clamping portion may also include two movable ends, and the two movable ends can move relative to each other, thereby facilitating the installation and removal of the light detection slide. The number of the clamping portions may be one or more. If the number of the clamping portions is multiple, the groove structure is arranged in a matrix.

[0062] In other examples, the loading mechanism includes a loading platform with a hollow structure. The loading platform includes at least one groove structure. The groove structures are multiple and arranged in a matrix. Each groove structure has a size equal to or larger than the optical detection slide. The bottom surface of each groove structure has a hollow region, and the samples evenly distributed on the optical detection slide correspond to the hollow region.

[0063] The terahertz wave generator emits terahertz waves toward the metal pattern layer of the light detection carrier.

[0064] The terahertz wave generator includes a light source and an optical system. The light source can be a broad-band illuminator that provides terahertz radiation, such as a mercury lamp. Alternatively, the light source can be an electromagnetic generator that generates terahertz radiation using lattice vibrations.

[0065] The optical system guides the terahertz waves emitted by the light source toward the light detection slide. The wavelength of the guided terahertz waves corresponds to the wavelength of the light detection slide. The optical system includes at least one of a light reflection component, a beam focusing component, a diffusion component, a spectroscopic component, and an optical filtering component in the direction of the light from the light source to change the direction of light propagation and / or the size of the light spot. Each component in the optical system can be designed based on at least one of optical lenses, electromagnetic circuits, or semiconductor integrated circuits.

[0066] The detection and processing device is disposed in the transmitted or reflected light path of the light detection carrier. The detection and processing device can be positioned adjacent to or attached to the other side of the object carrier to receive signal waves transmitted or reflected from the light detection carrier. Due to the metal pattern layer on the light detection carrier, the transmitted or reflected signal waves are polarization-independent.

[0067] To effectively prevent the material of the optical detection slide from interfering with component detection due to the influence of terahertz waves, the detection processing device must receive a signal wave reflecting the effect of the optical detection slide's own material on the terahertz waves. This signal wave is also called a reference signal wave. For example, before performing component detection, technicians first operate the terahertz wave detection equipment to perform the following operations: the terahertz wave generator emits terahertz waves; the detection processing device obtains the reference signal wave of the optical detection slide on which the sample is to be placed.

[0068] After the sample is evenly arranged on the light detection slide, the detection and processing device also receives absorption signal waves transmitted or reflected by the light detection slide itself and the sample. The absorption signal waves are generated when components in the sample absorb energy under the action of terahertz waves and are then transmitted or reflected by the light detection slide.

[0069] In some examples, to ensure that the detection and processing device receives both the reference and absorption signal waves, technicians must operate the terahertz wave detection equipment in a sequential manner. For example, they first place an empty optical detection slide on the loading mechanism and operate the terahertz wave detection equipment to ensure that the detection and processing device receives the reference signal wave. They then remove the optical detection slide and evenly arrange the samples, and then operate the terahertz wave equipment again to ensure that the detection and processing device receives the absorption signal wave. If the sample density required for the test requires adjustment, technicians must perform the evenly arranged sample operation on the optical detection slide multiple times and in a quantitative manner to ensure that the detection and processing device receives the corresponding absorption signal wave multiple times.

[0070] In other examples, to facilitate more efficient and accurate testing, the terahertz wave detection device also includes a sample collection mechanism for evenly distributing the sample to be tested on the optical detection slide. This allows technicians to simply place an empty optical detection slide into the detection device and perform component detection through automatic or manual operation.

[0071] Here, the sample collection structure includes: a sample container and a sample placement mechanism.

[0072] The sample container is used to store a powdered sample or a sample liquid. An example of the sample container is a test tube. The sample liquid is formed by mixing the powdered sample to be tested and a solution. The solution is a substance that makes the powdered sample to be tested uniformly distributed based on physical properties such as density or physical compatibility. Examples of the uniform distribution include a state formed by dissolution through a physical reaction, or a suspended state formed due to similar densities of the solution and the powdered sample. The physical reaction refers to a process of molecular diffusion, energy balance, or density balance.

[0073] The sample arranging mechanism is used to evenly arrange the sample in the sample container or the sample liquid on the light detection slide.

[0074] The sample placement mechanism for placing the sample may include, for example, a nozzle, a nozzle controller, and a nozzle movement mechanism. The nozzle controller is used to quantitatively aspirate the sample from the sample container and deliver it to the nozzle. Examples of the nozzle controller include a peristaltic pump. The nozzle is mounted on the nozzle movement mechanism. The nozzle movement mechanism is used to position the nozzle on the light detection slide and to move the nozzle away before the terahertz wave generator emits the terahertz wave.

[0075] The sample placement mechanism for placing the sample liquid includes, for example, a pipetting mechanism and a drying mechanism. The pipetting mechanism is used to drop the sample liquid formed by mixing the powdered sample in the solution onto the light detection slide.

[0076] Specifically, the pipetting mechanism is positioned at the sample container and the light detection slide, and moves between the two. The pipetting mechanism includes an extractor and a moving mechanism of the extractor. The extractor quantitatively absorbs the sample liquid and drops the absorbed sample liquid on the light detection slide. The extractor is assembled on the moving mechanism of the extractor, and is driven by the moving mechanism to move between the sample container and the light detection slide using positioning technology. When positioned at the sample container, the moving mechanism drives the extractor to extend into the sample container to quantitatively absorb the sample liquid. When positioned at the light detection slide, the moving mechanism drives the extractor to drop the quantitatively absorbed sample liquid onto the light detection slide. The volume of the quantitatively absorbed sample liquid is provided to cover at least one resonator unit on the light detection slide, so that the transmitted or reflected absorption signal wave contains polarization-independent absorption characteristics.

[0077] To prevent the components of the solution from absorbing or releasing energy due to the terahertz wave, which would contaminate the absorption signal waves transmitted or reflected by the light detection slide with characteristic information about the components in the solution, the solution must be removed before detection. The solution is a volatile liquid, such as ethanol or water. When the liquid mixed with the powdered sample is dropped onto the light detection slide, the powdered sample is evenly distributed on the slide after the solution evaporates.

[0078] The drying mechanism is used to remove the solution to form a powdered sample evenly distributed on the light detection slide. In some examples, the drying mechanism is a passive drying mechanism, such as a vent provided on the terahertz wave detection device, which is in air circulation with the carrier mechanism. The terahertz wave detection device presets a waiting time based on the volume of liquid quantitatively aspirated to allow the solution in the sample liquid to evaporate before emitting the terahertz wave. In other examples, the drying mechanism is an active drying mechanism, such as an air vent provided on the side of the carrier mechanism or in the detection chamber where the carrier mechanism is located, and a wind controller that creates air flow on the surface of the light detection slide. Examples of the wind controller include a ventilation fan and / or a heater. For example, after the pipetting mechanism drops the sample liquid on the light detection slide, the drying mechanism heats the carrier mechanism or the detection chamber where the carrier mechanism is located for a preset time to remove the volatile solution, so that the powdered sample in the sample liquid is evenly distributed on the light detection slide.

[0079] By using any of the above-mentioned layout methods, the detection and processing device can obtain the reference signal wave before the sample is laid out, and obtain the absorption signal wave after the sample is laid out.

[0080] The detection and processing device uses the reference signal wave to perform signal analysis on the absorption signal wave to obtain component information contained in the sample. The detection and processing device outputs a detection result of the sample's component information by executing a detection and processing method. The detection and processing device includes a terahertz wave detector and an electronic device.

[0081] The terahertz wave detector is used to convert the absorption signal wave and the reference signal wave into corresponding absorption electrical signals and reference electrical signals respectively.

[0082] Here, the terahertz wave detector converts optical signals into electrical signals using the principle of energy conversion between terahertz waves and electromagnetic waves. The terahertz wave detector can be a one-dimensional or two-dimensional detector. For example, the terahertz wave detector is an antenna for detecting terahertz waves, or a terahertz imaging device. The terahertz wave detector converts the strength of the sensed terahertz wave into a corresponding electrical signal. In this example, the terahertz wave detector receives the signal wave during the terahertz wave emission from the terahertz wave generator to obtain a reference signal wave and an absorption signal wave corresponding to at least one density during the terahertz wave action.

[0083] The terahertz wave detector converts the reference signal wave into a reference electrical signal and the absorption signal wave into an absorption electrical signal. The reference electrical signal and the absorption electrical signal may be analog signals. To facilitate data analysis by digital processing electronics, the reference electrical signal and the absorption electrical signal are digital signals obtained by sampling the analog signals.

[0084] The electronic device is a computing device capable of performing digital calculations and logical processing, examples of which include personal computers, servers, and devices containing embedded logic circuits. The electronic device can also function as the main device of a terahertz wave detection device, controlling the operation of the terahertz wave transmitter and terahertz wave detector within the terahertz wave detection device, and even controlling the sample acquisition device to ensure that the various hardware components execute in a timely manner. The electronic device includes at least a processor and memory, and may also include hardware such as an interface unit for various hardware components, a display unit, a network communication unit, and an input unit.

[0085] At least one memory is configured to store at least one program, which enables the at least one processor to execute the detection and processing method. The at least one memory also stores, for example, a reference electrical signal and an absorption electrical signal. The at least one program includes a program for a visual interface for technicians to operate, and a program for executing the detection and processing method when triggered by the visual interface.

[0086] Here, the at least one memory includes, but is not limited to, read-only memory (ROM), random access memory (RAM), and non-volatile RAM (NVRAM). For example, the at least one memory includes a flash memory device or other non-volatile solid-state storage device. In some embodiments, the at least one memory may also include a memory remote from one or more of the at least one processor, such as a network attached memory accessed via an RF circuit or an external port and a communication network, wherein the communication network may be the Internet, one or more intranets, local area networks, wide area networks, storage area networks, etc., or a suitable combination thereof. The memory controller may control access to the memory by other components of the device, such as the CPU and peripheral interfaces.

[0087] At least one interface unit, each interface unit being used to output a visual interface, receive human-computer interaction events generated by technicians' operations, and communicate data with the terahertz wave detector (and / or terahertz wave generator). For example, the interface device includes, but is not limited to, a serial interface such as an HDMI interface or a USB interface, or a parallel interface.

[0088] The network communication unit is hardware and software that uses a wired or wireless network for data transmission, and its examples include but are not limited to: an integrated circuit containing a network card, a local area network module such as a WiFi module or a Bluetooth module, a wide area network module such as a mobile network, etc.

[0089] The display unit is used to display a visual interface presented during operation of the data processing system, i.e., an operating interface. The display unit includes, for example, a display. When the display is integrated with a touch sensor, it can serve as a hardware device for displaying and generating input events. The display device can be connected to at least one processor via an interface unit (e.g., an HDMI interface) or a network communication device (e.g., a WiFi module) in an interface device.

[0090] The input unit is used for technicians to operate. The signals generated by the technicians' operations are processed by at least one processor to trigger the call of some programs to execute corresponding steps. Examples of the input device include a mouse, keyboard, input board, etc.

[0091] The at least one processor includes one or more general-purpose microprocessors, one or more application-specific processors (ASICs), one or more digital signal processors (DSPs), one or more field programmable gate arrays (FPGAs), or any combination thereof.

[0092] The at least one processor coordinates each hardware device to execute the detection processing method according to the at least one stored program. Figure 5 , which is a flow chart showing the electronic device executing the detection processing method.

[0093] In step S110 , a reference electrical signal reflecting a reference signal wave transmitted through or reflected by a terahertz wave through an unloaded light detection carrier is acquired.

[0094] The electronic device, in accordance with an operational sequence, controls the terahertz wave generator to emit terahertz waves during periods when the optical detection slide is idle, and controls the terahertz wave detector to receive the transmitted or reflected signal waves to generate a corresponding reference electrical signal. The electronic device stores this reference electrical signal in a memory for subsequent calculations. The reference electrical signal reflects the time domain signal during the period when the terahertz wave transmitted or reflected the idle optical detection slide.

[0095] In step S120, an absorption electrical signal reflecting the absorption signal wave of the terahertz wave transmitted or reflected by the light detection carrier carrying the uniformly distributed sample is obtained. Due to the polarization cancellation effect of the light detection carrier, the reference signal wave and the absorption signal wave are both polarization-cancelled signal waves.

[0096] The electronic device, in accordance with an operational sequence, controls the terahertz wave generator to emit terahertz waves after optical detection of at least one sample placement, and controls the terahertz wave detector to receive the transmitted or reflected signal wave, thereby obtaining at least one absorption electrical signal corresponding to the number of times. The electronic device stores each absorption electrical signal in a memory for execution of step S130. Each absorption electrical signal reflects the time domain signal during the optical detection period after the terahertz wave transmitted or reflected from the corresponding sample placement.

[0097] In step S130 , the reference electrical signal is used to perform spectrum analysis on the absorption electrical signal to obtain component information contained in the sample.

[0098] Here, the electronic device converts the obtained reference electrical signal and absorption electrical signal into reference spectrum data and absorption spectrum data in the frequency domain through time-domain to frequency-domain conversion. The sample's compositional information is detected by using the spectral changes in the absorption spectrum data relative to the reference spectrum data.

[0099] In some examples, electronic devices perform component detection based on the spectral changes between a single absorption signal and a reference signal. For samples containing multiple components (e.g., pharmaceutical samples), some components may be present at low concentrations, making it difficult for the terahertz wave detection equipment to extract a spectral description representing the absorption characteristics from the absorption signal. Therefore, by gradually increasing the density, the spectral changes between the absorption signal and the reference signal are detected at different densities, allowing analysis of multiple component information.

[0100] The electronic device executes step S131 to detect a first variation pattern of the spectrum of the absorption electrical signal relative to the spectrum of the reference electrical signal, and determines component information of the sample according to the first variation pattern.

[0101] The first variation pattern is obtained by pre-testing multiple known pharmaceutical ingredients using terahertz waves. The first variation pattern includes at least one of the following: a variation pattern based on a peak shift of a spectrum, a variation pattern based on an average width shift of a spectrum, and a variation pattern based on a peak shape of a spectrum.

[0102] In the first change law, there is a preset correspondence between the spectral feature interval describing the change law and the component information, or a correspondence between the spectral feature interval, the density interval of the sample, and the component information. Among them, the spectral feature is the various spectral data described in the first change law. The density interval is the volume of the sample covered by a unit area on the light detection slide. Here, based on the number of times the sample is arranged on the light detection slide and its quantitative information (such as solution concentration or powder spraying amount), the electronic device determines the density of the sample on the light detection slide. Any of the above correspondences is obtained in advance through experimental testing and can be stored in the electronic device in the form of a configuration table or the like.

[0103] In some embodiments, there is no overlap between the spectral feature intervals. For example, in the correspondence between the spectral feature intervals and the component information, there is no overlap between the spectral feature intervals. For another example, in the correspondence between the spectral feature intervals, the density intervals, and the component information, there is no overlap between the spectral feature intervals.

[0104] In other embodiments, the spectral feature intervals (or density intervals) corresponding to different component information may at most partially overlap. For example, in the correspondence between the spectral feature intervals, the density intervals, and the component information, the spectral feature intervals may partially overlap, and the density intervals may not overlap. For another example, in the correspondence between the spectral feature intervals, the density intervals, and the component information, the spectral feature intervals may not overlap, and the density intervals may partially overlap.

[0105] Taking the example of a first variation pattern including a variation pattern based on a peak offset of a spectrum, the electronic device extracts at least one peak from the received absorption spectrum data; using a single peak in the reference spectrum data or a peak within a preset frequency band as the reference peak, calculates the spectrum offset between each extracted peak and the reference peak; and determines the component information of the sample to be tested based on a predetermined correspondence between a spectrum offset range and the corresponding component information. An example of extracting the at least one peak includes determining relative peaks and relative valleys in the absorption spectrum data based on the amplitude variation within a unit frequency band, detecting the amplitude deviation between adjacent relative peaks and relative valleys, and determining as the peak in the absorption spectrum data the spectrum corresponding to the relative peak whose amplitude deviation exceeds a preset deviation threshold.

[0106] See also Figure 6 , which shows a waveform diagram of peaks in the baseline spectrum data and the absorption spectrum data. The electronic device detects the baseline spectrum data and absorption spectrum data, respectively. The dashed line represents the baseline spectrum data, and the solid line represents the absorption spectrum data. Based on any of the aforementioned correspondences, the electronic device detects the spectral deviation between the peaks of the baseline spectrum data and the absorption spectrum data to determine the corresponding component information.

[0107] Taking the first variation rule including the variation rule based on the average width offset of the spectrum as an example, the electronic device determines the spectrum range of the average width of the received reference spectrum data and the absorption spectrum data respectively, so as to represent the energy concentrated in the corresponding spectrum range of each spectrum data. The electronic device obtains the corresponding component information by detecting the offset of the spectrum range of the two types of spectrum data. Figure 6 The electronic device detects the offset between the respective spectrum ranges {a1, a2} and {a3, a4} of the reference spectrum data and the absorption spectrum data according to any of the above correspondences to determine the corresponding component information.

[0108] Taking the first change law including the change law based on the peak shape of the spectrum as an example, the electronic device determines the slopes between peaks and valleys in the received reference spectrum data and absorption spectrum data respectively; according to any of the above correspondences, the changes in the two slopes are detected to determine the corresponding component information.

[0109] As the density increases, the energy absorbed by the same component increases, and its corresponding absorption characteristics change. To this end, in another example, samples are quantitatively and repeatedly placed on a light detection slide, allowing the electronic device to repeatedly obtain absorption electrical signals at different densities. The detection processing method also includes step S132: detecting component information in the sample based on the sample accumulated on the light detection slide during each accumulation.

[0110] Here, component information in the sample is detected by analyzing spectrum deviations of a plurality of absorption spectrum data that change with density.

[0111] Specifically, the electronic device converts each acquired absorption electrical signal into corresponding absorption spectrum data and calculates the offsets of each absorption spectrum data relative to the reference spectrum data. In addition to detecting component information based on the first variation pattern mentioned in the previous example, the electronic device also determines the component information of the corresponding sample by detecting the second variation pattern formed by the changes in each offset.

[0112] Wherein, the second change rule is obtained by conducting terahertz wave tests on a plurality of known drug ingredients in advance. The second change rule includes the correspondence between various spectral feature intervals reflecting the gradual density increase obtained through pre-testing and the component information; or the correspondence between the rate of change of various spectral features relative to the density change and the component information. Wherein, the spectral features are various spectral data described in the corresponding second change rule. The density change interval is the change in the volume of the sample covered by a unit area on the light detection slide. The second change rule includes, for example, a rule determined based on at least one of the following for each spectrum obtained by multiple measurements: each offset of the spectral peak of each measurement, the frequency band of the characteristic peak in multiple measurements, and the average width offset of the spectrum in multiple measurements.

[0113] Taking the second change rule as an example, the rule includes the rule determined based on the various offsets of the spectrum peaks measured each time, the electronic device calculates the spectrum offset width of each offset, and / or the change of the spectrum offset width relative to the density change; and determines the corresponding component information based on the preset correspondence relationship.

[0114] Taking the second variation rule including the rule determined based on the frequency band of the characteristic peak in multiple measurements as an example, the electronic device counts the frequency spectrum position of the characteristic peak obtained in each measurement; and determines the corresponding component information based on the preset corresponding relationship.

[0115] Taking the second change rule as an example, the rule determined based on the average width offset of the spectrum in multiple measurements, the electronic device calculates the total offset of the average width offset obtained through multiple measurements, and / or the change of the average width offset relative to the density change; and determines the corresponding component information based on the corresponding relationship preset accordingly.

[0116] It should be noted that the electronic device can also determine the use of any one or more of the above-mentioned first change law and second change law based on a pre-known sample by detecting the spectrum of the absorbed electrical signal relative to the spectrum of the reference electrical signal, or by improving on at least one of the above-mentioned laws.

[0117] By using at least one of the above detection examples, multiple component information in the sample can also be detected. For example, by detecting that the component information in the sample includes active pharmaceutical ingredients such as ginsenosides and ammonium salicylate, it is determined that the sample to be tested contains ginseng. For another example, by detecting that the component information in the sample includes active pharmaceutical ingredients such as flavonoid glycosides and amino acids, it is determined that the sample to be tested contains Panax notoginseng. For another example, by detecting that the component information in the sample includes active pharmaceutical ingredients such as ginsenodiol monomer saponins, it is determined that the sample to be tested contains American ginseng. For another example, by detecting that the component information in the sample includes active pharmaceutical ingredients such as ginsenosides, ammonium salicylate, flavonoid glycosides, amino acids, etc., it is determined that the sample to be tested contains ginseng and Panax notoginseng.

[0118] The present application utilizes a light detection carrier with a metal pattern layer to eliminate the polarization of terahertz waves during transmission, so that the transmitted or reflected terahertz waves have polarization-independent characteristics. This characteristic effectively enhances the ease of detection of the absorption characteristics of the sample in the transmitted or reflected terahertz waves after absorbing the energy of the terahertz waves, and reduces the polarization properties of the signal waves. In addition, by using terahertz waves to detect the composition of the sample, since the influence of polarized light is effectively reduced, more accurate spectral characteristics can be obtained, effectively improving the sensitivity of the terahertz wave detection equipment. In addition, by using multiple quantitative dripping and drying methods to evenly distribute the samples, the terahertz wave detection equipment can perform multi-signal detection on the corresponding absorption signal waves of varying densities, thereby obtaining more accurate composition information. At the same time, the above operation avoids manual error and improves detection efficiency.

[0119] In addition, if the detection and processing method in the present application is implemented in the form of a software functional unit and sold or used as an independent product, it can be stored in a computer-readable storage medium. Based on this understanding, the technical solution of the present application, or the part that contributes to the prior art, or the part of the technical solution, can be embodied in the form of a software product, which is stored in a storage medium and includes a number of instructions for enabling a computer device (which can be a personal computer, server, or network device, etc.) to perform all or part of the steps of the method described in each embodiment of the present application.

[0120] In the embodiments provided herein, the computer readable and writable storage medium may include a read-only memory, a random access memory, an EEPROM, a CD-ROM or other optical disk storage device, a magnetic disk storage device or other magnetic storage device, a flash memory, a USB flash drive, a mobile hard disk, or any other medium that can be used to store desired program code in the form of instructions or data structures and can be accessed by a computer. In addition, any connection can be appropriately referred to as a computer readable medium. For example, if the instruction is sent from a website, a server or other remote source using a coaxial cable, a fiber optic cable, a twisted pair, a digital subscriber line (DSL) or wireless technologies such as infrared, radio and microwaves, the coaxial cable, fiber optic cable, twisted pair, DSL or wireless technologies such as infrared, radio and microwaves are included in the definition of the medium. However, it should be understood that computer readable and writable storage media and data storage media do not include connections, carriers, signals or other temporary media, but are intended to be non-temporary, tangible storage media. Disk and disc, as used in this application, includes compact disc (CD), laser disc, optical disc, digital versatile disc (DVD), floppy disk and Blu-ray disc where disks usually reproduce data magnetically, while discs reproduce data optically with lasers.

[0121] In one or more exemplary aspects, the functions described by the computer program of the method described herein can be implemented in hardware, software, firmware, or any combination thereof. When implemented in software, these functions can be stored or transmitted as one or more instructions or codes on a computer-readable medium. The steps of the method or algorithm disclosed in this application can be embodied in a processor-executable software module, wherein the processor-executable software module can be located on a tangible, non-transitory computer-readable and writable storage medium. The tangible, non-transitory computer-readable and writable storage medium can be any available medium that can be accessed by a computer.

[0122] The flowcharts and block diagrams in the accompanying drawings above of the present application illustrate the possible architecture, functions and operations of the systems, methods and computer program products according to various embodiments of the present application. Based on this, each box in the flowchart or block diagram can represent a module, program segment or a part of code, and the module, program segment or a part of code contains one or more executable instructions for realizing the specified logical function. It should also be noted that in some alternative implementations, the functions marked in the box can also occur in a different order than that marked in the accompanying drawings. For example, two boxes represented in succession can actually be executed substantially in parallel, and they can sometimes be executed in the opposite order, depending on the functions involved. It should also be noted that each box in the block diagram and / or flowchart, and the combination of the boxes in the block diagram and / or flowchart can be implemented by a dedicated hardware-based system that performs the specified function or operation, or can be implemented by a combination of dedicated hardware and computer instructions.

[0123] The above embodiments are merely illustrative of the principles and effects of this application and are not intended to limit this application. Anyone skilled in the art may modify or alter the above embodiments without departing from the spirit and scope of this application. Therefore, all equivalent modifications or alterations made by one of ordinary skill in the art without departing from the spirit and technical concepts disclosed in this application shall be covered by the claims of this application.

Claims

1. A light detection slide, characterized in that: include: a substrate layer that transmits or reflects terahertz waves; The metal pattern layer located on the surface of the substrate layer forms a polarization-cancelled reference signal wave under terahertz wave irradiation; and for carrying a sample to be tested; wherein the metal pattern layer comprises a plurality of resonator units, each resonator unit being composed of a plurality of metal resonators of a non-closed shape, wherein the opening of the metal resonator rotates in a clockwise / counterclockwise direction for one cycle to complete one cycle; During the terahertz wave irradiation, the light detection slide carrying the sample transmits or reflects an absorption signal wave with polarization offset, wherein the absorption signal wave is formed after the terahertz wave passes through the sample and absorbs energy; The substrate layer is made of polyimide, silicon dioxide, or quartz, which has good transmission or reflection capabilities for terahertz waves; The surface of the substrate layer is arranged with assembly grooves of a preset pattern, and a metal structure with a corresponding pattern matches the assembly grooves, so that the surface of the metal structure forms a metal pattern layer on the surface of the substrate layer; The plurality of metal resonators in the resonator unit as a whole offset polarizations with a plurality of orthogonal main directions and / or a plurality of opposite main directions; The metal resonator is in the shape of a broken line with a 60° angle. The three metal resonators in the resonator unit are in the shape of a centrally symmetrical non-closed equilateral triangular ring formed by rotation. The non-closed area formed by the interval between the two metal resonators is also centrally symmetrical. When the metal pattern layer and the substrate layer do not carry a sample, the metal pattern layer and the substrate layer generate a polarization-cancelled reference signal wave under the irradiation of the terahertz wave; The sample is a powdered sample, which is sprayed on the light detection slide to form a uniformly distributed sample to be detected; The detection processing method applicable to the light detection slide comprises the following steps: Step S110, obtaining a reference electrical signal reflecting a reference signal wave of a terahertz wave transmitted through or reflected from an unloaded light detection carrier; Step S120 , obtaining an absorption electrical signal reflecting an absorption signal wave of the terahertz wave transmitted through or reflected from the light detection carrier carrying the sample evenly distributed thereon; Step S130, using the reference electrical signal, performing spectrum analysis on the absorption electrical signal to obtain component information contained in the sample; Step S131, detecting a first variation pattern of the spectrum of the absorption electrical signal relative to the spectrum of the reference electrical signal, and determining component information of the sample according to the first variation pattern; Step S132: detecting component information of the sample on the optical detection slide based on each accumulation; Converting each previously acquired absorption electrical signal into corresponding absorption spectrum data; calculating the offsets of each absorption spectrum data relative to the reference spectrum data, and determining the component information in the corresponding sample by detecting the second variation pattern formed by the variation of each offset; The second variation rule includes a rule determined based on at least one of the following for each spectrum obtained from multiple measurements: each offset of the spectrum peak in each measurement, the frequency band of the characteristic peak in multiple measurements, and the average width offset of the spectrum in multiple measurements.

2. The light detection slide according to claim 1, wherein: Each metal resonator in the resonator unit is obtained by periodically rotating the same non-closed shape.

3. The light detection slide according to claim 2, characterized in that The non-closed shape includes a geometric figure having an opening.

4. The light detection slide according to claim 1 or 3, characterized in that: At least one of the size of the opening and the area of ​​the substrate layer covered by the metal resonator is related to the frequency range of the terahertz wave.

5. The light detection slide according to claim 1 or 3, characterized in that: The dimensions of the metal resonator are related to the frequency range of the terahertz wave.

6. The light detection slide according to claim 5, characterized in that The shape of the metal resonator includes a pattern with an opening including a non-closed loop.

7. The light detection slide according to claim 6, characterized in that At least one of the outer ring diameter and the inner ring diameter of the metal resonator is related to the frequency band range of the terahertz wave.

8. The light detection slide according to claim 1, wherein: The light detection carrier provides detection of samples arranged through multiple quantitative accumulations; wherein, during the terahertz wave detection period corresponding to each quantitatively accumulated sample, the light detection carrier carrying the corresponding accumulated sample transmits or reflects multiple absorption signal waves.

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