Electrical field stimulation device in conjunction with magnetic field therapy for cancer

Abstract

The application discloses an electric field stimulation device for treating cancer with a magnetic field, wherein the input of a power module is connected with a mobile power supply, the output of the power module is connected with the input of a digital control module, the output of the digital control module is connected with a voltage boosting module, the output of a clock module is connected with the digital control module, the output of the voltage boosting module is connected with a switch network module, the output of a motor driving module and a magnetic field control module are both connected with a magnetic field unit; the electric field unit comprises n sensor modules, n positive electrodes and n negative electrodes, n is a natural number, and each of the sensor modules, the positive electrodes and the negative electrodes are connected in sequence; a feedback unit comprises a signal amplifier and a signal acquisition module connected with each other. The application can improve the electric field treatment effect and reduce the side effects of high temperature generated by electric discharge on patients by adjusting the electrode placement position and the electrode discharge mode.

Description

TECHNICAL FIELD

[0001] The present application belongs to the field of medical devices, in particular to an electric field stimulation device for treating cancer in cooperation with magnetic field. BACKGROUND

[0002] Electric field therapy for tumor is one of the latest cancer treatment methods. Because of its minimally invasive or non-invasive treatment method, it has attracted the attention of many researchers. Studies have shown that electric field can cause dielectrophoresis of some proteins in mitosis of cancer cells, thereby affecting mitosis of cancer cells, in addition, electric field can also interfere with DNA replication and repair of cancer cells. In particular, the electric field direction can only destroy cell division when it is parallel to the long axis of cell division. Therefore, electric field therapy can effectively kill cancer cells to inhibit the development of tumors in patients to prolong the survival time of cancer patients. However, the existing electric field therapy equipment has the problem of long daily treatment time and electrode heating, which will cause patients to have side effects such as folliculitis, dry skin, and pruritus after long-term use.

[0003] The existing technology mainly uses a single electrode to generate a sinusoidal signal electric field for treatment. Although the rotation of the stimulating electrode is changed, because the single electrode is always used for stimulation, in order to ensure that the field strength reaches the effective level at the affected area, the power released by the single electrode will be at a high level and will cause the temperature of the electrode to rise. In addition, because it is a sinusoidal signal, it cannot be guaranteed that the electrode adjustment will always output at the highest power, which will result in a longer treatment time. In addition, the existing technology is a single electric field treatment, and the daily treatment time is more than 15 hours. SUMMARY

[0004] Therefore, the purpose of the present application is to provide an electric field stimulation device for treating cancer in cooperation with magnetic field, which can improve the treatment effect of electric field and reduce the side effects caused by high temperature generated by discharge by adjusting the placement position of the electrode and the discharge mode of the electrode.

[0005] To achieve the above purpose, the present application provides an electric field stimulation device for treating cancer in cooperation with magnetic field, which comprises a mobile power supply, a control unit, an electric field unit and a feedback unit, the control unit is connected with the mobile power supply, the electric field unit and the feedback unit respectively, the output of the electric field unit is connected with the feedback unit, wherein,

[0006] The control unit comprises a power supply module, a digital control module, a clock module, a voltage boosting module and a switch network module, wherein the input of the power supply module is connected with the mobile power supply, the output of the power supply module is connected with the input of the digital control module, the output of the digital control module is connected with the voltage boosting module, the output of the clock module is connected with the digital control module, and the output of the voltage boosting module is connected with the switch network module.

[0007] The electric field unit comprises n sensor modules, n positive electrodes and n negative electrodes, n being a natural number, each of the sensor modules, the positive electrodes and the negative electrodes being connected in sequence;

[0008] The feedback unit comprises a signal amplifier and a signal acquisition module connected in sequence.

[0009] Preferably, the power module is connected with a mobile power supply to supply power to the electric field stimulation device, and the power module adjusts the power of the mobile power supply to supply power at different frequencies and different voltages according to the requirements of the digital control module.

[0010] Preferably, the clock module provides time information for the digital control module, so that the digital control module controls the power supply duration of the power module.

[0011] Preferably, the digital control module is responsible for controlling the electric field intensity and frequency of the entire electric field stimulation device, and receives and processes information from the feedback unit, so as to realize self-adaptive adjustment of the electric field; if the signal intensity fed back by the feedback unit is within the set working range, the current working parameters do not need to be adjusted; if the signal intensity fed back by the feedback unit exceeds the set working range, the intensity and frequency of the electric field are inhibited or strengthened, so that the output of the entire electric field stimulation device always maintains the set working intensity.

[0012] Preferably, the boost module processes the input voltage from the digital control module to make it meet the output voltage requirements of the electric field stimulation device.

[0013] Preferably, the switch network module accepts the output voltage from the boost module and controls the sequence of the output voltage flowing to different positive electrodes in the electric field unit, and the switch network module comprises m power supplies, 4m totem pole drivers and m current sources, m being a natural number, after the current enters the switch network module, it is controlled by the power supply and then passes through the totem pole driver to generate a square wave signal output, and each positive electrode is controlled by a current source to output current.

[0014] Preferably, the sensor module acquires temperature information of the electric field unit and the electric field size of the position where the electric field unit is located in real time, and converts the information into a signal to feed back to the signal amplifier.

[0015] Preferably, the positive electrode comprises at least 4, is a needle electrode or a plane electrode, and is connected with the sensor module and the negative electrode to receive current from the corresponding current source and generate an electric field.

[0016] The number of the negative electrode is consistent with that of the positive electrode, and the negative electrode is a needle electrode or a plane electrode and forms a current loop with the positive electrode to generate electric fields of different directions and / or different modes in the electric field unit through different placement positions of the negative electrode and control of the switch network module.

[0017] Preferably, the positive electrode and the negative electrode are arranged in four pairs, and are arranged in a circumferential shape, and are sequentially arranged in a clockwise direction as a first positive electrode, a second positive electrode, a third positive electrode, a fourth positive electrode, a first negative electrode, a second negative electrode, a third negative electrode, and a fourth negative electrode, and are sequentially arranged at an angle of 45 degrees; the first positive electrode and the first negative electrode form a first electrode pair, and the like; two groups of electrode pairs output current stimulation simultaneously during use, and the first electrode pair and the third electrode pair or the second electrode pair and the fourth electrode pair output current stimulation, and form a cross electric field.

[0018] Preferably, the signal amplifier collects signals from the sensor module, amplifies the signals, and transmits the signals to the signal acquisition module.

[0019] The signal acquisition module receives signals from the signal amplifier and transmits the signals to the digital control module.

[0020] The present application has at least the following beneficial effects:

[0021] 1. Compared with the prior art, the present application simultaneously stimulates two pairs of electrodes and more, reduces the stimulation power at a single electrode to reduce the temperature rise at the electrode;

[0022] 2. Square wave signals are used to ensure that the electrode is replaced after one cycle of stimulation, and the electrode can be stimulated at the highest power at all times;

[0023] 3. The present application cooperates with a magnetic field to treat cancer, which can greatly reduce the required treatment time per day, thereby reducing the frequency of electrode replacement;

[0024] 4. The two pairs of electrodes arranged in a cross shape are more likely to ensure that the generated electric field is parallel to the long axis of more cancer cell division.

[0025] Through the above arrangement, the patient can have a better quality of life and a lower economic burden. BRIEF DESCRIPTION OF DRAWINGS

[0026] In order to make the purpose, technical scheme and beneficial effects of the present application clearer, the present application provides the following drawings for illustration:

[0027] Figure 1 The structural block diagram of the electric field stimulation device for treating cancer in cooperation with a magnetic field in the embodiment of the present application;

[0028] Figure 2 The specific structural block diagram of the electric field stimulation device for treating cancer in cooperation with a magnetic field in the embodiment of the present application;

[0029] Figure 3The switching network module structure diagram of the electric field stimulation device for treating cancer in cooperation with a magnetic field according to an embodiment of the present application;

[0030] Figure 4 The positive electrode and negative electrode layout diagram of the electric field stimulation device for treating cancer in cooperation with a magnetic field according to an embodiment of the present application;

[0031] Figure 5 The electric field application diagram of the electrode pair of the electric field stimulation device for treating cancer in cooperation with a magnetic field according to an embodiment of the present application;

[0032] Figure 6 The electric field application diagram of the electrode pair of the electric field stimulation device for treating cancer in cooperation with a magnetic field according to another embodiment of the present application;

[0033] Figure 7 The electrode switching mode diagram of the electric field stimulation device for treating cancer in cooperation with a magnetic field according to an embodiment of the present application. DETAILED DESCRIPTION

[0034] In order to make the objectives, technical solutions and advantages of the present application clearer, the present application is further described in detail below with reference to specific embodiments and the accompanying drawings.

[0035] Reference is made to Figure 1 and Figure 2 The structural diagram of the electric field stimulation device for treating cancer in cooperation with a magnetic field according to an embodiment of the present application, which comprises a mobile power supply 61, a control unit 62, an electric field unit 63 and a feedback unit 64, wherein,

[0036] The control unit comprises a power supply module 621, a digital control module 622, a clock module 623, a voltage boosting module 624 and a switching network module 625; the electric field unit 63 comprises a sensor module 631, a positive electrode 632 and a negative electrode 633; the feedback unit 64 comprises a signal amplifier 641 and a signal acquisition module 642;

[0037] The power supply module 621 is connected with the mobile power supply 61, for providing external power supply for the whole system, and the power supply module 621 adjusts the electric energy of the mobile power supply 61, and supplies power with different frequencies and different voltages according to the requirements of the control unit by the digital control module 622;

[0038] The clock module 623 is connected with the digital control module 622, for providing time information to the digital control module 622 so as to control the power supply duration of the power supply module by the digital control module 622;

[0039] The digital control module 622 is responsible for controlling the electric field intensity and frequency of the whole system, and receives and processes information from the feedback unit 64, thereby playing a role in adaptive adjustment of the system electric field. If the various signal intensities fed back by the feedback unit are within the set working range, the current working parameters do not need to be adjusted; if the various signal intensities fed back by the feedback unit 64 are not within the set working range, the intensity and frequency of the electric field are adjusted in a manner of suppression or strengthening, so that the output of the system electric field always remains at the set working intensity.

[0040] The boost module 624 processes the input voltage from the digital control module 622 to raise it to meet the output voltage requirements of the system;

[0041] The switch network module 625 accepts the output voltage from the boost module 624 and controls the sequence of its flow to different positive electrodes 632 in the electric field unit 63;

[0042] The sensor module 631 is connected with the switch network module 625, and collects the temperature information of the electric field unit and the electric field intensity of the position where the electric field unit 63 is located in real time and converts them into signals to feed back to the signal amplifier 641;

[0043] The positive electrode 632 is at least 4 groups, which can be needle-shaped electrodes or planar electrodes, and is connected with the sensor module 631 and the negative electrode 633 to receive the current from the corresponding current source 141 and generate an electric field;

[0044] The negative electrode 633 is consistent with the number of positive electrodes 632 and is at least 4 groups, which can be needle-shaped electrodes or planar electrodes, and forms a current loop with the positive electrode 632, and by different placement positions of the negative electrode 633 and the control of the switch network module 625, different direction and mode electric fields can be generated in the electric field unit;

[0045] The signal amplifier 641 collects signals from the sensor module 151 and amplifies and transmits them to the signal acquisition module 642;

[0046] The signal acquisition module 642 receives signals from the signal amplifier 161 and transmits them to the digital control module 622.

[0047] Referring to Figure 3 , the switch network module 625 includes a power supply 501, a totem pole driver 502, and a current source 503. Each positive electrode 632 has an independent power supply 501 for power supply. After the current enters the switch network module 625, a square wave signal output is generated through the control of the totem pole driver 502, and each positive electrode 632 has an independent current source 503 for controlling the current.

[0048] Referring to Figures 4-6, including 4 pairs of electrodes, 4 pairs of electrodes are respectively first electrode pair 1 composed of first positive electrode 11 and first negative electrode 12, second electrode pair 2 composed of second positive electrode 21 and second negative electrode 22, third electrode pair 3 composed of third positive electrode 31 and third negative electrode 32, fourth electrode pair 4 composed of fourth positive electrode 41 and fourth negative electrode 42. First electrode pair 1, second electrode pair 2, third electrode pair 3, fourth electrode pair 4 form a circumferential shape and enclose the tumor T.

[0049] Referring to Figure 5 、 Figure 6 As shown in the figure, when the electric field treatment is carried out, two pairs of stimulating electrodes emit stimulation at the same time, wherein the first positive electrode 11 and the first negative electrode 12 and the third positive electrode 31 and the third negative electrode 32 form a group, and the second positive electrode 21 and the second negative electrode 22 and the fourth positive electrode 41 and the fourth negative electrode 42 form a group, and each group of electrodes forms a cross electric field to stimulate the tumor T.

[0050] Referring to Figure 7 , the upper figure is the release situation of the square wave signal of the first electrode pair 1 and the third electrode pair 3, and the lower figure is the release situation of the square wave signal of the second electrode pair 2 and the fourth electrode pair 4. The first electrode pair 1 and the third electrode pair 3, the second electrode pair 2 and the fourth electrode pair 4 alternately stimulate every time t, and the time t is the inverse of the stimulation frequency.

[0051] In the specific embodiment, the application is provided with 2a (a≥2) pairs of electrodes, each electrode has its own independent power supply and current source, and the number of electrodes stimulated at the same time is a pair, and the electric field formed by the electrodes stimulated at the same time needs to form a cross at the treatment site. The frequency of the transverse electric field formed is 100-300 kHz, and the stimulation time of the electrode per cycle is the inverse of the transverse electric field frequency. The constant current size passed by the current source 503 is 0-1mA, and the current signal is a square wave signal.

[0052] The electrode of the application has small temperature rise and is not easy to cause side effects to the patient; it does not need to be worn for a long time, and good tumor inhibition effect can be obtained after short-term use, and it will not cause skin-related side effects caused by long-term wearing; the electrode does not need to be replaced frequently, can better save the cost of the patient, and can form a cross electric field to more easily ensure that the generated electric field is parallel to the more cancer cell division long axis, thereby improving the treatment effect.

[0053] Finally, it should be pointed out that the above description is only a specific embodiment of the application, although the application has been described in detail through the above preferred embodiments, but those skilled in the art should understand that various changes can be made in form and details without departing from the scope defined by the claims of the application.

Claims

1. An electric field stimulation device for treating cancer in conjunction with a magnetic field, characterized in that, It includes a power bank, a control unit, an electric field unit, and a feedback unit. The control unit is connected to the power bank, the electric field unit, and the feedback unit respectively. The output of the electric field unit is connected to the feedback unit. The control unit includes a power module, a digital control module, a clock module, a boost module, and a switch network module. The input of the power module is connected to a power bank, the output of the power module is connected to the input of the digital control module, the output of the digital control module is connected to the boost module, the output of the clock module is connected to the digital control module, and the output of the boost module is connected to the switch network module. The electric field unit includes n sensor modules, n positive electrodes, and n negative electrodes, where n is a natural number. Each sensor module, positive electrode, and negative electrode are connected in sequence. The sensor modules collect the temperature information of the electric field unit and the magnitude of the electric field at the location of the electric field unit in real time, and convert them into signals to be fed back to the signal amplifier. The feedback unit includes a signal amplifier and a signal acquisition module connected together; The switching network module receives the output voltage from the boost module and controls the order in which it flows to different positive electrodes in the electric field unit. The switching network module includes m power supplies, 4m totem pole drivers, and m current sources, where m is a natural number. After the current enters the switching network module, it is controlled by the power supply and then by the totem pole drivers to generate a square wave signal output. Each positive electrode is controlled by a current source to control the current output to it.

2. The electric field stimulation device for cancer treatment in conjunction with a magnetic field according to claim 1, characterized in that, The power module is connected to a mobile power supply to power the electric field stimulation device. The power module adjusts the power of the mobile power supply and supplies power at different frequencies and voltages according to the needs of the digital control module.

3. The electric field stimulation device for cancer treatment in conjunction with a magnetic field according to claim 1, characterized in that, The clock module provides time information to the digital control module, thereby enabling the digital control module to control the power supply duration of the power module.

4. The electric field stimulation device for cancer treatment in conjunction with a magnetic field according to claim 1, characterized in that, The digital control module is responsible for controlling the electric field strength and frequency of the entire electric field stimulation device, and receiving and processing information from the feedback unit to achieve adaptive adjustment of the electric field. If the signal strength fed back by the feedback unit is within the set working range, there is no need to adjust the current working parameters. If the signal strength fed back by the feedback unit exceeds the set working range, the strength and frequency of the electric field are suppressed or enhanced so that the output of the electric field of the entire electric field stimulation device is always maintained at the set working strength.

5. The electric field stimulation device for cancer treatment in conjunction with a magnetic field according to claim 1, characterized in that, The boost module processes the input voltage from the digital control module and increases it to meet the output voltage requirements of the electric field stimulation device.

6. The electric field stimulation device for cancer treatment in conjunction with a magnetic field according to claim 1, characterized in that, The positive electrode includes at least four electrodes, which are needle-shaped electrodes or planar electrodes, connected to the sensor module and the negative electrode, receiving current from the corresponding current source and generating an electric field. The number of negative electrodes is the same as that of positive electrodes. They are needle-shaped electrodes or planar electrodes, forming a current loop with the positive electrodes. By different placement positions of the negative electrodes and the control of the switching network module, electric fields of different directions and / or different modes are generated in the electric field unit.

7. The electric field stimulation device for cancer treatment in conjunction with a magnetic field according to claim 1, characterized in that, The positive and negative electrodes are arranged in four pairs in a circular pattern, with the first positive electrode, second positive electrode, third positive electrode, fourth positive electrode, first negative electrode, second negative electrode, third negative electrode, and fourth negative electrode arranged in a clockwise direction, each at a 45° angle. The first positive electrode and the first negative electrode form the first electrode pair, and so on. In use, both sets of electrode pairs output current to stimulate each other simultaneously, either the first electrode pair and the third electrode pair or the second electrode pair and the fourth electrode pair, forming a cross electric field.

8. The electric field stimulation device for cancer treatment in conjunction with a magnetic field according to claim 1, characterized in that, The signal amplifier collects signals from the sensor module, amplifies them, and transmits them to the signal acquisition module. The signal acquisition module receives signals from the signal amplifier and transmits them to the digital control module.

Images