A sample detection apparatus and method

Abstract

The embodiment of the present application discloses a sample detection device, comprising: a card cartridge for accommodating a detection card containing a sample and a reagent; a colorimetric detection device comprising a colorimetric detection module and a first detection area; an impedance detection device comprising an impedance detection module and a second detection area; a turbidimetric detection device comprising a turbidimetric detection module and a third detection area; a luminescence detection device comprising a luminescence detection module and a fourth detection area; a horizontal guide rail assembly for driving the card cartridge to slide to the first detection area, the second detection area, the third detection area and the fourth detection area in time sequence; and a vertical guide rail assembly for sequentially pushing a piston of the detection card to slide. The embodiment of the present application also discloses a sample detection method. The embodiment of the present application solves the technical problem of how to implement combined detection of multiple methodologies on a single sample on a single device.

Description

TECHNICAL FIELD

[0001] Embodiments of the present application relate to the technical field of in-vitro detection. More specifically, embodiments of the present application relate to a sample detection device and method. BACKGROUND

[0002] Traditional sample detection devices generally only have a single function, that is, a sample detection device generally can only detect a single category of items of a sample, which can use one or two detection methods. For example, a detection device for blood cell analysis can use impedance method and colorimetric method to jointly detect and realize blood routine analysis. With the advancement of technology, after adding the turbidimetric method, C-reactive protein (a specific protein) can be detected. If more items of a sample need to be detected (requiring the use of impedance method, colorimetric method, turbidimetric method, chemiluminescence immunoassay, etc.), at least two or more devices need to be configured for impedance / colorimetric (or / and turbidimetric) test, separate turbidimetric test, and chemiluminescence test. For primary medical institutions, configuring multiple test devices has different difficulties in cost, space, benefit, etc., which leads to poor test work. SUMMARY

[0003] Embodiments of the present application provide a sample detection device and method, which solve the technical problem of how to implement joint detection of multiple methodologies on a single device for a single sample. Embodiments of the present application are mainly realized through the following technical solutions:

[0004] <Embodiments of the present application first aspect>

[0005] The first aspect of the embodiments of the present application provides a sample detection device, comprising:

[0006] A card slot for accommodating a detection card containing a sample and reagents;

[0007] A colorimetric detection device comprising a colorimetric detection module and a first detection area, wherein the colorimetric detection module is used to detect the detection card in the first detection area;

[0008] An impedance detection device comprising an impedance detection module and a second detection area, wherein the impedance detection module is used to detect the detection card in the second detection area;

[0009] A turbidimetric detection device comprising a turbidimetric detection module and a third detection area, wherein the turbidimetric detection module is used to detect the detection card in the third detection area;

[0010] A luminescence detection device comprising a luminescence detection module and a fourth detection area, wherein the luminescence detection module is used to detect the detection card in the fourth detection area;

[0011] A horizontal guide rail assembly, the card slot is in sliding connection with the horizontal guide rail assembly, and the card slot slides on the horizontal guide rail assembly to the first detection area, the second detection area, the third detection area and the fourth detection area in sequence;

[0012] A vertical guide rail assembly, the vertical guide rail assembly pushes the piston of the detection card to slide in sequence;

[0013] When the card slot slides to the first detection area, the vertical guide rail assembly pushes the piston to slide to a first predetermined area of the detection card, so that the mixed solution of the sample and the reagent enters a colorimetric detection area of the detection card, and the colorimetric detection module performs colorimetric detection on the mixed solution;

[0014] When the card slot slides to the second detection area, the vertical guide rail assembly pushes the piston to slide to a second predetermined area of the detection card, so that the mixed solution enters an impedance detection area of the detection card, and the impedance detection module performs impedance detection on the mixed solution;

[0015] When the card slot slides to the third detection area, the vertical guide rail assembly pushes the piston to slide to a third predetermined area of the detection card, so that the mixed solution enters a turbidimetric detection area of the detection card, and the turbidimetric detection module performs turbidimetric detection on the mixed solution;

[0016] When the card slot slides to the fourth detection area, the vertical guide rail assembly pushes the piston to slide to a fourth predetermined area of the detection card, so that the mixed solution enters a luminescence detection area of the detection card, and the luminescence detection module performs luminescence detection on the mixed solution.

[0017] Further, the first detection area is located at a first detection port of the colorimetric detection module; the second detection area is located at a second detection port of the impedance detection module; the third detection area is located at a third detection port of the turbidimetric detection module; and the fourth detection area is located at a fourth detection port of the luminescence detection module.

[0018] Further, the sample detection device further comprises a control module, which is used to send a detection signal to the impedance detection module, the colorimetric detection module, the turbidimetric detection module and the luminescence detection module.

[0019] Further, the horizontal guide rail assembly comprises a horizontal guide rail member and a first sliding block, the first sliding block is in sliding connection with the horizontal guide rail member, and the card slot is arranged on the first sliding block.

[0020] Further, the vertical guide rail assembly comprises a vertical guide rail member and a second sliding block, the second sliding block is in sliding connection with the vertical guide rail member, the second sliding block is provided with a push rod, and the push rod is used for pushing the piston.

[0021] Further, the sample detection device further comprises a driving module, and the first sliding block and the second sliding block are connected with the driving module respectively.

[0022] Further, the driving module is electrically connected with a control module, and the control module is further used for sending a control signal to the driving module.

[0023] Further, the sample detection device further comprises a light shielding member and an incubation member, and the light shielding member and the incubation member are electrically connected with the control module.

[0024] Further, the driving module comprises a first driving member, a second driving member, a third driving member, a fourth driving member, a first transmission member, a second transmission member, a third transmission member and a fourth transmission member, the first driving member is connected with the first transmission member, the first transmission member is connected with the first sliding block, the second driving member is connected with the second transmission member, the second transmission member is connected with the second sliding block, the third driving member is connected with the third transmission member, the third transmission member is connected with the light shielding member, the fourth driving member is connected with the fourth transmission member, and the fourth transmission member is connected with the mixing member.

[0025] Further, the sample detection device further comprises a base, a light shielding cover and a support bracket, one end of the support bracket is connected with the vertical guide rail assembly, and the other end is connected with the base; the light shielding cover is connected with the base to form a containing cavity, and the containing cavity is used for containing the cartridge, the horizontal guide rail assembly, the vertical guide rail assembly, the mixing member, the light shielding member and the incubation member.

[0026] Further, the sample detection device further comprises a display module, the display module is electrically connected with the control module, and the display module is used for realizing interaction between the sample detection device and a user.

[0027] Further, the sample detection device further comprises a printing module, the printing module is electrically connected with the control module, and the printing module is used for printing a detection result.

[0028] <Embodiment of the present application second aspect>

[0029] The second aspect of the embodiment of the present application provides a sample detection method, applied to the sample detection device provided by the first aspect of the embodiment of the present application, and the sample detection method comprises the following steps.

[0030] The colorimetric detection module receives the first detection signal and performs colorimetric detection;

[0031] The impedance detection module receives the second detection signal and performs impedance detection;

[0032] The turbidimetric detection module receives the third detection signal and performs turbidimetric detection;

[0033] The luminescence detection module receives the fourth detection signal and performs luminescence detection.

[0034] The beneficial effects of the embodiments of the present application include:

[0035] In the prior art, the traditional sample detection equipment can only realize single-method detection of samples. If multiple-method detection is required, multiple detection equipment is needed. Unlike this, the colorimetric detection device, impedance detection device, turbidimetric detection device and luminescence detection device are integrated in one equipment in the embodiments of the present application. The card slot is slid to the first detection area of the colorimetric detection device, the second detection area of the impedance detection device, the third detection area of the turbidimetric detection device and the fourth detection area of the luminescence detection device in time sequence by setting the horizontal guide rail assembly. In the corresponding detection area, the vertical guide rail assembly pushes the piston of the detection card to slide in time sequence, so that the sample enters the detection space of the detection card corresponding to the detection area, thereby realizing corresponding item detection. Based on this, the embodiments of the present application can realize joint detection of multiple items (methods) on a single sample on a single equipment.

[0036] The embodiments of the present application integrate multiple sample detection devices for detecting samples in one equipment, which can realize one equipment with multiple uses and reduce the use cost of users.

[0037] Since the detection card of the embodiments of the present application has self-contained reagents, the problem of opening the bottle and the expiration date of the reagent bottle of the traditional equipment can be effectively avoided.

[0038] The colorimetric detection device, impedance detection device, turbidimetric detection device and luminescence detection device in the embodiments of the present application can be one or more, and can be combined as needed, which is not limited herein.

[0039] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which the embodiments of the present application belong.

[0040] The various features and implementations of the embodiments of the present application mentioned in the above aspects can be applied to other aspects as appropriate with appropriate modifications. Therefore, specific features in one aspect can be appropriately combined with specific features in other aspects.

[0041] Other advantages, objects, and features of the embodiments of the application will be apparent from the following specification, and will be understood by persons skilled in the art. BRIEF DESCRIPTION OF DRAWINGS

[0042] In order to more clearly illustrate the technical solutions of the embodiments of the application, the following will briefly introduce the drawings needed to be used in the description of the embodiments of the application. Obviously, the drawings in the following description are only some embodiments of the application, and for those skilled in the art, other drawings can also be obtained from these drawings without creative labor.

[0043] Figure 1 Structure block diagram of the sample detection device in some embodiments of the embodiments of the application;

[0044] Figure 2 Structure block diagram of the driving module, horizontal guide rail assembly, vertical guide rail assembly, light shielding member and mixing member in some embodiments of the embodiments of the application;

[0045] Figure 3 Structure schematic diagram of the sample detection device in some embodiments of the embodiments of the application;

[0046] Figure 4 Structure schematic diagram of the sample detection device in some embodiments of the embodiments of the application;

[0047] Figure 5 Structure schematic diagram of the sample detection device in some embodiments of the embodiments of the application;

[0048] Figure 6 Structure schematic diagram of the sample detection device in some embodiments of the embodiments of the application;

[0049] Figure 7 Structure schematic diagram of the card slot, first driving member, first transmission member, incubation member, card slot support and horizontal guide rail assembly in some embodiments of the embodiments of the application;

[0050] Figure 8 Structure schematic diagram of the vertical guide rail assembly, second driving member, second transmission member and detection card in some embodiments of the embodiments of the application;

[0051] Figure 9 Structure schematic diagram of the light shielding member, third driving member and third transmission member in some embodiments of the embodiments of the application;

[0052] Figure 10 Structure schematic diagram of the mixing member, fourth driving member and fourth transmission member in some embodiments of the embodiments of the application;

[0053] Figure 11 Structure diagram of the light shield in some embodiments of the sample detection device of the present application;

[0054] Figure 12 Flow chart of the sample detection method in some embodiments of the present application;

[0055] Explanation of reference signs:

[0056] 1, sample detection device; 10, card slot; 11, detection card; 111, piston; 20, colorimetric detection device; 30, impedance detection device; 40, turbidimetric detection device; 50, luminescence detection device; 60, horizontal guide rail assembly; 61, horizontal guide rail member; 62, first sliding block; 70, vertical guide rail assembly; 71, vertical guide rail member; 72, second sliding block; 80, control module; 90, display module; 100, printing module; 110, driving module; 120, mixing member; 130, light shielding member; 140, incubation member; 150, base; 160, light shield; 170, support bracket; 180, card slot bracket; 190, shell; A1, first driving member; B1, second driving member; C1, third driving member; D1, fourth driving member; A2, first transmission member; B2, second transmission member; C2, third transmission member; D2, fourth transmission member; E1, first detection area; E2, second detection area; E3, third detection area; E4, fourth detection area. DETAILED DESCRIPTION

[0057] In order to make the objectives, technical solutions and advantages of the present application clearer, the technical solutions in the embodiments of the present application will be described clearly and completely below with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are some but not all of the embodiments of the present application. Based on the embodiments in the present application, all other embodiments obtained by those of ordinary skill in the art without creative work fall within the scope of protection of the embodiments of the present application.

[0058] The terms “first”, “second”, “third” and “fourth” and the like in the specification of the embodiments of the present application are used to distinguish different objects, rather than to describe a specific order of the objects. For example, the first detection area, the second detection area, the third detection area and the fourth detection area are used to distinguish different detection areas, rather than to describe a specific order of the detection areas.

[0059] In the embodiments of this application, the terms "exemplary" or "for example" are used to indicate that something is an example, illustration, or description. Any embodiment or design that is described as "exemplary" or "for example" in the embodiments of this application should not be construed as being more preferred or advantageous than other embodiments or design. Specifically, the use of the terms "exemplary" or "for example" is intended to present the relevant concepts in a specific manner.

[0060] It should be noted that, in this document, the terms “comprising,” “including,” or any other variations thereof are intended to cover non-exclusive inclusion, for example, a process, method, system, product, or device that includes a series of steps or units is not necessarily limited to those steps or units that are explicitly listed, but may include other steps or units that are not explicitly listed or that are inherent to such process, method, product, or device.

[0061] This sample testing equipment is used for in vitro diagnostics. The detection methods employed include impedance spectroscopy, colorimetry, turbidimetry, and chemiluminescence immunoassay. Impedance spectroscopy and colorimetry are commonly used in blood cell analysis to analyze the number, morphology, and certain components of blood cells; colorimetry is commonly used in biochemical analysis; turbidimetry is commonly used in the analysis of specific proteins; and chemiluminescence immunoassay is commonly used in the immunoassay of proteins, peptides, and small molecules.

[0062] The specific implementation methods of the embodiments of this application will be further described below with reference to the accompanying drawings.

[0063] like Figures 1-6 The diagram shown is a structural block diagram of the sample detection device 1 provided in an embodiment of this application. Figure 1 In this context, the sample detection device 1 includes:

[0064] Card compartment 10, used to hold test cards 11 containing samples and reagents;

[0065] The colorimetric detection device 20 includes a colorimetric detection module and a first detection area E1, wherein the colorimetric detection module is used to detect the detection card 11 located in the first detection area E1;

[0066] The impedance detection device 30 includes an impedance detection module and a second detection area E2, wherein the impedance detection module is used to detect the detection card 11 located in the second detection area E2;

[0067] The turbidimetric detection device 40 includes a turbidimetric detection module and a third detection area E3, wherein the turbidimetric detection module is used to detect the detection card 11 located in the third detection area E3;

[0068] The light emission detection device 50 includes a light emission detection module and a fourth detection area E4, wherein the light emission detection module is used to detect the detection card 11 located in the fourth detection area E4;

[0069] horizontal guide rail assembly 60, the card cartridge 10 is slidingly connected with the horizontal guide rail assembly 60, and the card cartridge 10 slides on the horizontal guide rail assembly 60 to the first detection area E1, the second detection area E2, the third detection area E3 and the fourth detection area E4 in sequence;

[0070] vertical guide rail assembly 70, the vertical guide rail assembly 70 slidingly pushes the piston 111 of the detection card 11 in sequence;

[0071] When the card cartridge 10 slides to the first detection area E1, the vertical guide rail assembly 70 slidingly pushes the piston 111 to a first predetermined area of the detection card 11, so that the mixed solution of sample and reagent enters a colorimetric detection area of the detection card 11, and a colorimetric detection module performs colorimetric detection on the mixed solution;

[0072] When the card cartridge 10 slides to the second detection area E2, the vertical guide rail assembly 70 slidingly pushes the piston 111 to a second predetermined area of the detection card 11, so that the mixed solution enters an impedance detection area of the detection card 11, and an impedance detection module performs impedance detection on the mixed solution;

[0073] When the card cartridge 10 slides to the third detection area E3, the vertical guide rail assembly 70 slidingly pushes the piston 111 to a third predetermined area of the detection card 11, so that the mixed solution enters a turbidimetric detection area of the detection card 11, and a turbidimetric detection module performs turbidimetric detection on the mixed solution;

[0074] When the card cartridge 10 slides to the fourth detection area E4, the vertical guide rail assembly 70 slidingly pushes the piston 111 to a fourth predetermined area of the detection card 11, so that the mixed solution of sample enters a luminescence detection area of the detection card 11, and a luminescence detection module performs luminescence detection on the mixed solution.

[0075] It should be noted that the impedance detection module includes a signal generator, a first detector, a discriminator, a threshold control unit, a counting unit, an automatic compensation unit and a first control interface. The impedance detection module is used for white blood cell differential count, red blood cell count and platelet count.

[0076] The colorimetric detection module comprises a first light source unit, a first lens, a first filter, a second detector and a second control interface. The colorimetric detection module is used for hemoglobin concentration detection. The light of the light source unit is green light (the wavelength is preferably 525 nm); the lens is used for adjusting the size of the light spot, so that the size of the light spot can be adapted to the detection port area of the detector; the detector can adopt a photoelectric sensor. Further, the light source can be a tungsten lamp and a corresponding filter member. According to the detection needs, the filter member is set to obtain light of a corresponding wavelength.

[0077] The turbidimetric detection module comprises a second light source unit, a second lens, a second filter, a third detector and a third control interface. The turbidimetric detection module is used for specific protein concentration detection or biochemical detection. It should be noted that when the turbidimetric detection module is used for specific protein concentration detection, the second light source unit can select red light (the wavelength is preferably 630 nm to 670 nm); when the turbidimetric detection module is used for biochemical detection, the second light source unit can use a combination of white light and a filter member. By setting the filter member, light of a specified wavelength suitable for a specific detection item is generated. The second lens is used to adjust the size of the light spot, so that the size of the light spot is adapted to the detection port area of the detector. The third detector is a photoelectric sensor.

[0078] The luminescence detection module comprises a photon detector, a photon counter and a fourth control interface. The photon detector adopts a photomultiplier tube or a silicon photomultiplier tube. The photon detector is used to collect photon signals, and the collected photon signals are counted by the photon counter to obtain the number of photons.

[0079] It should be understood that the impedance detection module, the colorimetric detection module, the turbidimetric detection module and the luminescence detection module are not limited to the above examples, and can be set by those skilled in the art according to actual needs.

[0080] It should be further noted that, Figure 1 The dashed line part (i.e. the detection card 11 and the piston 111) is only the detection object of the sample detection device 1 and does not belong to the sample detection device 1.

[0081] In other embodiments, when the sample detection device 1 performs colorimetric detection, the vertical guide rail assembly 70 can first push the piston 111 to slide to a first predetermined area of the detection card 11, so that the mixed liquid enters the colorimetric detection space of the detection card 11, and then the card cartridge 10 slides to the first detection area E1, and the colorimetric detection module performs colorimetric detection on the mixed liquid. Similarly, when the sample detection device 1 performs impedance detection, turbidimetric detection and luminescence detection, the detection can also be performed in the above manner.

[0082] In some embodiments, the colorimetric detection device 20 and the turbidimetric detection device 40 can be integrated on the same circuit board.

[0083] The sample detection apparatus 1 further comprises a control module 80, which is configured to send detection signals to the impedance detection module, the colorimetric detection module, the turbidimetric detection module, and the luminescence detection module.

[0084] The control module 80 is electrically connected to the impedance detection module through the first control interface, electrically connected to the colorimetric detection module through the second control interface, electrically connected to the turbidimetric detection module through the third control interface, and electrically connected to the luminescence detection module through the fourth control interface.

[0085] The detection signal sent by the control module 80 to the impedance detection module is a detection signal for starting impedance detection.

[0086] The detection signal sent by the control module 80 to the colorimetric detection module is a detection signal for starting colorimetric detection.

[0087] The detection signal sent by the control module 80 to the turbidimetric detection module is a detection signal for starting turbidimetric detection.

[0088] The detection signal sent by the control module 80 to the luminescence detection module is a detection signal for starting luminescence detection.

[0089] The sample detection apparatus 1 further comprises a display module 90, which is electrically connected to the control module 80, and is configured to realize the interaction between the sample detection apparatus 1 and a user.

[0090] The display module 90 comprises a display screen, an input / output interface, a core device component, and a fifth control interface.

[0091] The input / output interface can adopt one or more of the following modes: touch, printing, keyboard, mouse, network port, USB, etc.

[0092] The core device component adopts a computer (containing Windows, MacOS, Linux device, etc.), a mobile phone (Android, iOS, etc.), or a tablet computer (Android, iOS, etc.).

[0093] The display module 90 is electrically connected to the control module 80 through the fifth control interface.

[0094] The sample detection apparatus 1 comprises a printing module 100, which is electrically connected to the control module 80, and is configured to print the detection results.

[0095] As shown in Figure 2 , the horizontal guide rail assembly 60 comprises a horizontal guide rail member 61 and a first slider 62, the first slider 62 is in sliding connection with the horizontal guide rail member 61, and the cartridge 10 is arranged on the first slider 62. In other embodiments, the cartridge 10 can be connected with the first slider 62 through a cartridge support 180.

[0096] The vertical guide rail assembly 70 comprises a vertical guide rail member 71 and a second slider 72, the second slider 72 is in sliding connection with the vertical guide rail member 71, and the second slider 72 is provided with a push rod 721 for pushing the piston 111.

[0097] The sample detection device 1 further comprises a driving module 110, and the first slider 62 and the second slider 72 are respectively connected with the driving module 110. The driving module 110 drives the first slider 62 to slide on the horizontal guide rail member 61, and the driving module 110 drives the second slider 72 to slide on the vertical guide rail member 71 to push the piston 111, so that the reagent and the sample are mixed.

[0098] The driving module 110 is electrically connected with a control module 80, and the control module 80 is further used for sending a control signal to the driving module 110.

[0099] The control signal is a signal for starting or closing the driving module 110.

[0100] The first detection area E1 is located at a first detection port of the colorimetric detection module; the second detection area E2 is located at a second detection port of the impedance detection module; the third detection area E3 is located at a third detection port of the turbidimetric detection module; and the fourth detection area E4 is located at a fourth detection port of the luminescence detection module.

[0101] The sample detection device 1 further comprises a mixing member 120, a light shielding member 130 and an incubation member 140, and the mixing member 120, the light shielding member 130 and the incubation member 140 are electrically connected with the control module 80.

[0102] As shown in Figure 2 , Figure 7 , Figure 8 , Figure 9 and Figure 10 , the driving module 110 comprises a first driving member A1, a second driving member B1, a third driving member C1, a fourth driving member D1, a first transmission member A2, a second transmission member B2, a third transmission member C2 and a fourth transmission member D2.

[0103] The second driving member B1 is connected with the second transmission member B2 to drive the second transmission member B2 to rotate; the first transmission member A2 is connected with the first sliding block 62 to drive the first sliding block 62 to slide on the horizontal guide rail assembly 60.

[0104] The second driving member B1 is connected with the second transmission member B2 to drive the second transmission member B2 to rotate; the second transmission member B2 is connected with the second sliding block 72 to drive the second sliding block 72 to slide on the vertical guide rail assembly 70 to push the piston 111, drive the movement (flow) of the sample and the reagent, and mix the reagent and the sample.

[0105] The third driving member C1 is connected with the third transmission member C2 to drive the third transmission member C2 to rotate; the third transmission member C2 is connected with the light shielding member 130 to open or close the light shielding member 130.

[0106] The fourth driving member D1 is connected with the fourth transmission member D2 to drive the fourth transmission member D2 to rotate; the fourth transmission member D2 is connected with the mixing member 120 to start or close the mixing member 120.

[0107] The first driving member A1, the second driving member B1, the third driving member C1 and the fourth driving member D1 are motors; the first transmission member A2, the second transmission member B2 and the fourth transmission member D2 are screw rods; and the third transmission member C2 is a gear. In other embodiments, the first transmission member A2, the second transmission member B2, the third transmission member C2 and the fourth transmission member D2 can be other members with transmission function, which can be set according to actual needs by those skilled in the art, and the embodiments of the present application do not make further limitation.

[0108] The second driving member B1 drives the movement (flow) of the sample and the reagent, which means that the mixing and / or dilution of the sample and the reagent in the detection card 11 are completed in the detection card 11, and the sample detection device 1 does not have a complex liquid path control, thereby simplifying the device and eliminating cross contamination in detection.

[0109] As Figure 4 , 5As shown in Figure 11, the sample detection device 1 further includes a base 150, a light shield 160, and a support bracket 170. One end of the support bracket 170 is connected to the vertical guide rail assembly 70, and the other end is connected to the base 150. The light shield 160 is connected to the base 150 to form a receiving cavity, which is used to receive the card compartment 10, the horizontal guide rail assembly 60, the vertical guide rail assembly 70, the mixing component 120, the light shielding component 130, and the incubation component 140.

[0110] like Figure 3 As shown, the sample detection device 1 also includes a housing 190, which is connected to the base 150, specifically, by a threaded connection or a snap-fit ​​connection. The connection method between the housing 190 and the base 150 can be set by those skilled in the art according to actual needs.

[0111] The impedance detection module, the colorimetric detection module, the turbidimetric detection module, and the luminescence detection module can be implemented as plug-ins.

[0112] In practical applications, the sample detection device 1 can be implemented through the following example:

[0113] The user inputs the items to be tested through the display module 90, such as colorimetric testing, impedance testing, and turbidimetric testing. The control module 80 sends a start signal to the first driving component A1 based on the input item. At this time, the first driving component A1 drives the first slider 62, causing the card holder 10 to slide on the horizontal guide rail component 61 to the first detection area E1. The control module 80 then sends a start signal to the second driving component B1, causing the second driving component B1 to drive the second slider 72 to slide on the vertical guide rail component 71, pushing the piston 111 to slide to the first predetermined area of ​​the detection card 11. Next, the control module 80 sends a detection signal to the colorimetric testing module, and the colorimetric testing module begins testing. After the test is completed, the first driving component A1 drives the first slider 62, causing the card holder 10 to slide on the horizontal guide rail component 61 to the second detection area E2. The second driving component B1 drives the second slider 72 to slide on the vertical guide rail component 71, pushing the piston 111 to slide to the second predetermined area of ​​the detection card 11. Then, the control module 80 sends a detection signal to the impedance testing module, and the impedance testing module begins testing. After the test is completed, the first driving component A1 drives the first slider 62, causing the card slot 10 to slide on the horizontal guide rail component 61 to the third detection area E3. The second driving component B1 drives the second slider 72 to slide on the vertical guide rail component 71, pushing the piston 111 to slide to the third predetermined area of ​​the detection card 11. Then, the control module 80 sends a detection signal to the turbidity detection module, and the turbidity detection module starts the test. After the test is completed, the printing module 100 prints the test results.

[0114] <Sample Detection Methods>

[0115] like Figure 12 As shown, a second aspect of this application provides a sample detection method, applied to the sample detection device provided in the first aspect of this application. The sample detection method includes:

[0116] S101, The colorimetric detection module receives the first detection signal and performs colorimetric detection.

[0117] S102, The impedance detection module receives the second detection signal and performs impedance detection.

[0118] S103. The turbidimetric detection module receives the third detection signal and performs turbidimetric detection.

[0119] S104. The light emission detection module receives the fourth detection signal and performs light emission detection.

[0120] In a specific embodiment, the sample detection method can be implemented using the following steps:

[0121] First, the detection card 11 loaded with sample and reagent is put into the card slot 10;

[0122] Second, the display module 90 sends the received detection instruction sequence to the control module 80, and the control module 80 temporarily stores the instruction sequence for standby;

[0123] Third, the control module 80 instructs the driving module 110 to drive the horizontal guide rail assembly 60 to operate according to the predetermined instruction, and the card slot 10 is driven by the first sliding block 62 to run horizontally until the piston 111 is aligned with the push rod 721, and then the first sliding block 62 stops running;

[0124] Fourth, the control module 80 instructs the driving module 110 to drive the vertical guide rail assembly 70 to operate according to the predetermined instruction, and the second sliding block 72 drives the push rod 721 to run downward to push the piston 111 to slide to the first predetermined area of the detection card 11, so that the mixed solution of sample and reagent enters the colorimetric detection area of the detection card 11;

[0125] Fifth, the control module 80 instructs the driving module 110 to drive the vertical guide rail assembly 70 to operate according to the predetermined instruction, and the second sliding block 72 drives the push rod 721 to run upward to the initial position;

[0126] Sixth, the control module 80 instructs the driving module 110 to drive the horizontal guide rail assembly 60 to operate according to the predetermined instruction, and the card slot 10 is driven by the first sliding block 62 to run horizontally until the first detection port;

[0127] Seventh, the control module 80 instructs the colorimetric detection device 20 to start colorimetric detection according to the predetermined instruction;

[0128] Eighth, after the colorimetric detection is completed, the control module 80 instructs the driving module 110 to drive the horizontal guide rail assembly 60 to operate according to the predetermined instruction, and the card slot 10 is driven by the first sliding block 62 to run horizontally until the piston 111 is aligned with the push rod 721, and then the first sliding block 62 stops running, at this time, the detection card 11 is at the second detection port;

[0129] Ninth, the control module 80 instructs the driving module 110 to drive the vertical guide rail assembly 70 to operate according to the predetermined instruction, and the second sliding block 72 drives the push rod 721 to run downward to push the piston 111 to slide to the second predetermined area of the detection card 11, so that the mixed solution enters the impedance detection area of the detection card 11;

[0130] Tenth, the control module 80 instructs the impedance detection device 30 to start impedance detection according to the predetermined instruction, and at the same time, the control module 80 instructs the driving module 110 to drive the vertical guide rail assembly 70 to operate according to the predetermined instruction, so that the second sliding block 72 drives the push rod 721 to run downward to push the piston 111 to make the mixed solution flow;

[0131] Eleventh, after the completion of impedance detection, the control module 80 instructs the drive module 110 to drive the vertical guide rail assembly 70 to operate according to the predetermined instructions, the second sliding block 72 drives the push rod 721 to run downward, and the push rod 721 pushes the piston 111 to slide to the third predetermined area of the detection card 11, so that the mixed liquid enters the turbidimetry detection area of the detection card 11;

[0132] Twelfth, the control module 80 instructs the drive module 110 to drive the vertical guide rail assembly 70 to operate according to the predetermined instructions, the second sliding block 72 drives the push rod 721 to run upward to the initial position;

[0133] Thirteenth, the control module 80 instructs the drive module 110 to drive the horizontal guide rail assembly 60 to operate according to the predetermined instructions, the card bin 10 is driven by the first sliding block 62 to run horizontally to the third detection port;

[0134] Fourteenth, if necessary, the control module 80 instructs the drive module 110 to drive the mixing member 120 to mix the mixed liquid according to the predetermined instructions;

[0135] Fifteenth, if necessary, the control module 80 instructs the drive module 110 to drive the incubation member 140 to incubate the mixed liquid according to the predetermined instructions;

[0136] Sixteenth, the control module 80 instructs the turbidimetry detection device 40 to start turbidimetry detection according to the predetermined instructions;

[0137] Seventeenth, after the completion of turbidimetry detection, the control module 80 instructs the drive module 110 to drive the horizontal guide rail assembly 60 to operate according to the predetermined instructions, the card bin 10 is driven by the first sliding block 62 to run horizontally, and when the piston 111 is aligned with the push rod 721, the first sliding block 62 stops running;

[0138] Eighteenth, the control module 80 instructs the drive module 110 to drive the vertical guide rail assembly 70 to operate according to the predetermined instructions, the second sliding block 72 drives the push rod 721 to run downward, and the push rod 721 pushes the piston 111 to slide to the fourth predetermined area of the detection card 11, so that the mixed liquid enters the luminescence detection area of the detection card 11;

[0139] Nineteenth, the control module 80 instructs the drive module 110 to drive the vertical guide rail assembly 70 to operate according to the predetermined instructions, the second sliding block 72 drives the push rod 721 to run upward to the initial position;

[0140] Twentieth, the control module 80 instructs the drive module 110 to drive the horizontal guide rail assembly 60 to operate according to the predetermined instructions, the card bin 10 is driven by the first sliding block 62 to run horizontally to the fourth detection port;

[0141] Twenty-first, if necessary, the control module 80 instructs the drive module 110 to drive the light shielding member 130 to shield the ambient light according to the predetermined instruction;

[0142] Twenty-second, if necessary, the control module 80 instructs the drive module 110 to drive the incubation member 140 to incubate the mixed solution according to the predetermined instruction;

[0143] Twenty-third, the control module 80 instructs the light emission detection device 50 to start light emission detection according to the predetermined instruction;

[0144] Twenty-fourth, after the detection of multiple items is completed, the control module 80 instructs the drive module 110 to drive the horizontal guide rail assembly 60 to operate, and the cartridge 10 is horizontally moved to the outside of the machine under the drive of the first sliding block 62.

[0145] The above describes the embodiments of the present application and the implementation manners thereof, which is not restrictive, and the embodiments of the present application shown in the drawings are only one of the implementation manners, and the actual structure is not limited thereto. In summary, if a person skilled in the art is inspired by the above, without departing from the creative purpose of the embodiments of the present application, similar structural manners and embodiments are not creatively designed, which should belong to the protection scope of the embodiments of the present application.

Claims

1. A sample detection apparatus, characterized by, The sample detection device comprises: a card slot for accommodating a detection card containing a sample and reagents; a colorimetric detection device comprising a colorimetric detection module and a first detection area, wherein the colorimetric detection module is used for detecting the detection card in the first detection area; an impedance detection device comprising an impedance detection module and a second detection area, wherein the impedance detection module is used for detecting the detection card in the second detection area; a turbidimetric detection device comprising a turbidimetric detection module and a third detection area, wherein the turbidimetric detection module is used for detecting the detection card in the third detection area; a luminescence detection device comprising a luminescence detection module and a fourth detection area, wherein the luminescence detection module is used for detecting the detection card in the fourth detection area; a horizontal guide rail assembly, the card slot is slidably connected to the horizontal guide rail assembly, and the card slot slides on the horizontal guide rail assembly to the first detection area, the second detection area, the third detection area and the fourth detection area in sequence; a vertical guide rail assembly, the vertical guide rail assembly pushes a piston of the detection card to slide in sequence; when the card slot slides to the first detection area, the vertical guide rail assembly pushes the piston to slide to a first predetermined area of the detection card, so that a mixed solution of the sample and the reagents enters a colorimetric detection area of the detection card, and the colorimetric detection module performs colorimetric detection on the mixed solution; when the card slot slides to the second detection area, the vertical guide rail assembly pushes the piston to slide to a second predetermined area of the detection card, so that the mixed solution enters an impedance detection area of the detection card, and the impedance detection module performs impedance detection on the mixed solution; when the card slot slides to the third detection area, the vertical guide rail assembly pushes the piston to slide to a third predetermined area of the detection card, so that the mixed solution enters a turbidimetric detection area of the detection card, and the turbidimetric detection module performs turbidimetric detection on the mixed solution; when the card slot slides to the fourth detection area, the vertical guide rail assembly pushes the piston to slide to a fourth predetermined area of the detection card, so that the mixed solution enters a luminescence detection area of the detection card, and the luminescence detection module performs luminescence detection on the mixed solution, the horizontal guide rail assembly comprises a horizontal guide rail member and a first sliding block, the first sliding block is slidably connected to the horizontal guide rail member, and the card slot is arranged on the first sliding block, the vertical guide rail assembly comprises a vertical guide rail member and a second sliding block, the second sliding block is slidably connected to the vertical guide rail member, and the second sliding block is provided with a push rod for pushing the piston.

2. The sample testing device of claim 1, wherein, The sample detection device further comprises a control module for sending detection signals to the impedance detection module, the colorimetric detection module, the turbidimetric detection module and the luminescence detection module.

3. The sample testing device of claim 2, wherein, The sample detection device further comprises a display module and a printing module, the display module is electrically connected to the control module, the printing module is electrically connected to the control module, the display module is used for realizing the interaction between the sample detection device and the user, and the printing module is used for printing the detection result.

4. The sample testing device of claim 3, wherein, The sample detection device further comprises a driving module, and the first slider and the second slider are connected to the driving module respectively. The driving module is electrically connected to a control module, and the control module is configured to send a control signal to the driving module.

5. The sample testing device of claim 4, wherein, The sample detection device further comprises a mixing member, and the mixing member is electrically connected to the driving module.

6. The sample testing device of claim 5, wherein, The first detection area is located at a first detection port of the colorimetric detection module; the second detection area is located at a second detection port of the impedance detection module; the third detection area is located at a third detection port of the turbidimetric detection module; and the fourth detection area is located at a fourth detection port of the luminescence detection module.

7. The sample testing device of claim 6, wherein, The sample detection device further comprises a light shielding member and an incubation member, and the light shielding member and the incubation member are electrically connected to the driving module.

8. A sample detection method applied to the sample detection device according to any one of claims 1-7, characterized in that, The sample detection device comprises: The colorimetric detection module receives a first detection signal and performs colorimetric detection; The impedance detection module receives a second detection signal and performs impedance detection; The turbidimetric detection module receives a third detection signal and performs turbidimetric detection; The luminescence detection module receives a fourth detection signal and performs luminescence detection.

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