Supplementing algorithm and device for circulating liquid solute concentration and portable artificial kidney

Abstract

The application discloses a supplement algorithm for the concentration of circulating liquid solute, a device and a portable artificial kidney. In the circulating liquid configuration stage, the supplement algorithm comprises solid solute and pure water mixing addition and liquid solute concentrate and pure water mixing addition, and corresponding high-precision supplement algorithms for the concentration of solubility are provided for the solid solute and pure water mixing addition and the liquid solute concentrate and pure water mixing addition. The supplement algorithm for the concentration of circulating liquid solute in the portable artificial kidney system is described in detail through the supplement description of the embodiments. The application provides an accurate and reliable calculation method for the configuration of the circulating liquid in the portable artificial kidney system, and guarantees the treatment effect and safety of patients.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of medical equipment, and particularly relates to a supplement algorithm for the concentration of dissolved substances in circulating liquid, a device and a portable artificial kidney. BACKGROUND

[0002] Peritoneal dialysis is one of the main treatment methods for patients with end-stage renal disease. It mainly uses the peritoneum of the human body as a semi-permeable membrane to remove excess water, metabolic products and toxins in the body, so as to achieve the purpose of blood purification and replacement of kidney function.

[0003] The currently widely used peritoneal dialysis treatment method has many advantages such as "home treatment, hospital management", saving medical resources, etc. However, patients usually need to be treated once a day in the morning, noon and evening, which severely limits the freedom of patients and makes them unable to return to society, resulting in heavy burden on the family. In addition, the specifications of peritoneal dialysis fluid used by patients are relatively single, which cannot meet the complex treatment needs of patients, and the prescription cannot be adjusted in real time, so that the sufficiency of dialysis treatment cannot be effectively guaranteed. In addition, a large amount of dialysis fluid is needed during treatment, and the cleanliness of the environment also has a higher requirement.

[0004] The portable artificial kidney combines the device with the human body, is not limited by time and place, is simple and easy to treat, can realize real-time adjustment of the prescription, and can better guarantee the treatment effect, so as to meet the daily needs of patients such as business trips and travel, greatly improve the physiological and psychological state of patients, and is the development direction of kidney replacement equipment.

[0005] Further, one of the important links in the portable artificial kidney system using the principle of peritoneal dialysis is to realize the recycling of dialysis liquid. The waste liquid drained from the abdominal cavity is removed of part of the toxins through a toxin removal device, and part of the dissolved substances that can be reused are retained to obtain an aqueous solution, and appropriate amounts of dissolved substances such as glucose, sodium chloride, calcium chloride and magnesium chloride are added to configure new dialysis liquid that can be injected into the abdominal cavity of the human body for dialysis. This process is called configuration of circulating liquid. If the concentration of dissolved substances in the configured circulating liquid is inaccurate, it will affect the dialysis treatment effect of the patient, and even cause certain harm to the patient.

[0006] Therefore, in the configuration process of the circulating liquid, by supplementing the dissolved substances in the circulating liquid with high precision, the concentration configuration accuracy of the circulating liquid is improved, which can effectively guarantee the treatment effect and safety of the patient, and has significant economic and social benefits. SUMMARY

[0007] The present application relates to the field of medical equipment, and particularly relates to a supplement algorithm for the concentration of dissolved substances in circulating liquid, a device and a portable artificial kidney.

[0008] The technical scheme for achieving the object of the present application is as follows:

[0009] An algorithm for supplementing the concentration of dissolved substances in circulating fluid, used in a portable artificial kidney circulation system, comprising the following steps in the preparation of the circulating fluid:

[0010] For the mixing of solid dissolved substances and pure water, the following steps are included:

[0011] Step 1: Read the required amount of circulating fluid V set , and the concentration of dissolved substances ω set ;

[0012] Step 2: Read the concentration of dissolved substances in the initial liquid measured by the dissolved substance microsensor, and after non-linear compensation, obtain the concentration value ω f ;

[0013] Step 3: Obtain the amount of initial liquid V1 entering the preparation device through a high-precision flow sensor;

[0014] Step 4: Calculate the amount of dissolved substances in the liquid M1 = ω f * V1;

[0015] Step 5: Calculate the amount of pure water to be supplemented V 水 = V set -V1;

[0016] Step 6: Supplement pure water, and obtain the actual amount of liquid V2 supplemented by the flow sensor;

[0017] Step 7: The total amount of liquid in the prepared circulating fluid V 总 = V1+V2;

[0018] Step 8: Calculate the total amount of dissolved substances M 总 = ω set * V 总 ;

[0019] Step 9: Calculate the amount of dissolved substances to be supplemented M 补 = M 总 -M1;

[0020] Step 10: Supplement dissolved substances, complete the preparation of circulating fluid, and measure the non-linear compensated concentration of dissolved substances ω New ;

[0021] Step 11: Calculate determine the acceptable error σ of the concentration of dissolved substances:

[0022] 1) If , then step 14;

[0023] 2) If Then step 12; then the solute concentration ω new Too high,

[0024] 3) If Then step 13; then the solute concentration ω new Too low,

[0025] Step 12: Solute concentration ω new Too high, dilute with pure water, calculate the amount of water added

[0026] Pure water is added, V 总 = V 总 + V 补 , proceed to step 10;

[0027] Step 13: Solute concentration ω new Too low, continue solute supplement operation, calculate the amount of solute supplement

[0028] M' 补 = (ω set - ω New ) * V 总 , proceed to step 10;

[0029] Step 14: The circulating liquid configuration is completed.

[0030] For the mixed addition of liquid solute concentrate and pure water, including the following steps:

[0031] Step 1: Read the circulating liquid configuration amount V set , circulating liquid solute concentration ω set ;

[0032] Step 2: Read the solute concentration measured by the solute microsensor in the initial liquid, and obtain the concentration value ω f after nonlinear compensation;

[0033] Step 3: Obtain the initial liquid amount V1 entering the configuration device through a high-precision flow sensor;

[0034] Step 4: Calculate the solute content in the liquid M1 = ω f * V1;

[0035] Step 5: Calculate the solute supplement amount M 补 = V set * ω set - M1;

[0036] Step 6: Liquid solute concentrate concentration ω con , calculate the required solute concentrate supplement amount

[0037] V con = M补 / ω con , liquid concentration liquid supplement is carried out, and the actual liquid amount V2 of the supplement of the solute concentrate is obtained through the flow sensor;

[0038] Step 7: the amount V of pure water to be supplemented is calculated 水 = V set -V1-V2;

[0039] Step 8: pure water supplement is carried out, and the actual amount V3 of the supplemented pure water is obtained through the flow sensor;

[0040] Step 9: the actual total supplement amount V is calculated 总 =V1+V2+V3;

[0041] Step 10: the mixing and addition of the liquid solute concentrate and the pure water are completed, and the solute concentration after the non-linear compensation is ω New ;

[0042] Step 11: the difference between ω and the acceptable solute concentration error σ is calculated ;

[0043] 1) if ω < σ, then step 14;

[0044] 2) if ω > σ, then step 11; then the solute concentration ω new is too high,

[0045] 3) if ω < σ, then step 13; then the solute concentration ω new is too low,

[0046] Step 12: the solute concentration ω new is too high, dilution with pure water is carried out, and the amount of water to be added is calculated

[0047] pure water supplement is carried out, V′ 总 = V 总 +V 补水 , and step 10 is carried out;

[0048] Step 13: the solute concentration ω new is too low, and solute supplement operation needs to be continued, and the amount of solute supplement is calculated

[0049] step 10 is carried out;

[0050] Step 14: the circulating liquid configuration is completed.

[0051] For the two methods described above, namely the mixed addition of solid solute and pure water, and the mixed addition of liquid solute concentrate and pure water, the acceptable solute concentration error σ is less than ±0.2%.

[0052] Accordingly, the present invention also provides a high-precision replenishment device for the solute concentration of circulating fluid for use in a portable artificial kidney circulation system, which includes the mixed addition of solid elements and pure water and the mixed addition of liquid concentrate and pure water during the circulating fluid preparation stage.

[0053] Accordingly, the present invention also provides a portable artificial kidney, which, in the circulating fluid preparation stage, includes the mixed addition of solid elements and pure water and the mixed addition of liquid concentrate and pure water, and further includes at least the aforementioned high-precision replenishment device for circulating fluid solute concentration.

[0054] Compared with the prior art, the present invention has the following significant advantages: The present invention realizes an algorithm, device and portable artificial kidney for supplementing the concentration of solutes in circulating fluid. In the circulating fluid preparation stage, it includes the mixed addition of solid solutes and pure water as well as the mixed addition of liquid solute concentrate and pure water, which has a better effect on supplementing the concentration of solutes in circulating fluid and improves the safety of treatment. Attached Figure Description

[0055] Figure 1 This is a schematic diagram of an embodiment of a portable artificial kidney provided by the present invention.

[0056] Figure 2 This is a schematic diagram of the high-precision replenishment device for the solute concentration of circulating liquid provided by the present invention.

[0057] Figure 3 This is a schematic diagram of an embodiment of the high-precision replenishment device for the solute concentration of circulating liquid provided by the present invention.

[0058] Figure 4 A flowchart of an embodiment of the algorithm for supplementing the concentration of solute in circulating liquid provided by the present invention.

[0059] Figure 5 A flowchart of another embodiment of the algorithm for supplementing the concentration of solute in the circulating liquid provided by the present invention. Detailed Implementation

[0060] The present invention will now be further described with reference to the accompanying drawings.

[0061] like Figure 1 The diagram shown is a schematic representation of an embodiment of a portable artificial kidney provided by the present invention. In this embodiment, the portable artificial kidney includes:

[0062] A portable artificial kidney 1, and a catheter 7, a catheter 8 for connecting with a patient 9, the artificial kidney draws dialysis waste liquid from the abdominal cavity of the patient through the catheter 7, and obtains fresh dialysis liquid (circulation liquid) after treatment, and injects the fresh dialysis liquid into the abdominal cavity of the patient through the catheter 8.

[0063] In this embodiment, the artificial kidney 1 mainly includes a main controller 2, a pump 3, a valve 4, a toxin removal device 5, and a high-precision supplement device 6 for solutes.

[0064] Specifically, the pump 3 is used for transporting fluid, mainly transporting dialysis waste liquid from the abdominal cavity of the patient through the catheter 7, and transporting fresh dialysis liquid after treatment to the abdominal cavity of the patient through the catheter 8.

[0065] The valve 4 is used for controlling the opening and closing of the fluid passage, and cooperates with the pump to control the opening and closing of the passage of the catheter 7 and the catheter 8 when transporting fluid.

[0066] The toxin removal device 5 is used for removing toxic and harmful substances in the dialysis waste liquid, while retaining part of the reusable solutes.

[0067] The high-precision supplement device 6 for solutes is used for supplementing the required solutes in the circulation liquid in an appropriate amount, and reconfiguring the circulation liquid.

[0068] The main controller 2 is used for controlling other components of the artificial kidney, and can realize the functions of draining dialysis waste liquid, supplementing solutes in circulation liquid, and injecting new circulation liquid.

[0069] As shown in Figure 3 FIG. 1 is a structural schematic diagram of an embodiment of a high-precision supplement device for solutes in circulation liquid provided by the present application, and in this embodiment, the supplement device includes:

[0070] The first motion executing mechanism 10, the second motion executing mechanism 11, the first injector 12, the second injector 13, the preparation bag 14, the pure water storage bag 15, the flow sensor 16, the two-way electromagnetic valve 17, the first branch pipeline 181, the second branch pipeline 182, the third branch pipeline 183 and the fourth branch pipeline 184; the first motion executing mechanism 10 comprises a first motor 19, a first coupling 20, a first bearing 21, a first screw rod 22, a first sliding block 23 and a first fixed seat 24, the first motor 19 is fixed on the first fixed seat 24, the first coupling 20 is fixed on the first fixed seat 24 and connected with the output shaft of the first motor 19 and the first screw rod 22, the outer ring of the first bearing 21 is fixed on the first fixed seat 24, the inner ring is fixed on the end of the first screw rod 22, the first sliding block 23 is connected on the first screw rod 22 through internal threads, and the outer part is connected with the first fixed seat 24, when the first motor 19 drives the first screw rod 22 to rotate, the first sliding block 23 is limited to move back and forth along the direction of the first screw rod 22 due to the contact connection of the first fixed seat 24; the second motion executing mechanism 11 comprises a second motor 25, a second coupling 26, a second bearing 27, a second screw rod 28, a second sliding block 29 and a second fixed seat 30, the second motor 25 is fixed on the second fixed seat 30, the second coupling 26 is fixed on the second fixed seat 30 and connected with the output shaft of the second motor 25 and the second screw rod 28, the outer ring of the second bearing 27 is fixed on the second fixed seat 30, the inner ring is fixed on the end of the second screw rod 28, the second sliding block 29 is connected on the second screw rod 28 through internal threads, and the outer part is connected with the second fixed seat 30, when the second motor 25 drives the second screw rod 28 to rotate, the second sliding block 29 is limited to move back and forth along the direction of the second screw rod 28 due to the contact connection of the second fixed seat 30; the first motion executing mechanism 10 and the second motion executing mechanism 11 are in a 90° direction, the first fixed seat 24 and the second sliding block 29 are fixedly connected, when the second motor 25 rotates, the second sliding block 29 drives the first fixed seat 24 to move up and down, thereby controlling the internal recess structure of the first sliding block 23 to select the connection with the tail push rod of the first injector 12 or the second injector 13; the first sliding block 23 is connected with the tail push rod of the first injector 12 and the second injector 13 through the internal recess structure, the first motion executing mechanism 10 drives the tail push rod of the first injector 12 and the second injector 13 by controlling the back and forth movement of the first sliding block 23, thereby controlling the injection of the substances in the first injector 12 and the second injector 13; the first injector 12 stores solid dissolving substances inside, and is connected with the preparation bag 14 through the first branch pipeline 181; the second injector 13 stores liquid dissolving substance concentrate inside, and is connected with the preparation bag 14 through the second branch pipeline 182; the first one-way valve 31 is fixed on the first branch pipeline 181 connected between the first injector 12 and the preparation bag 14, and the second one-way valve 32 is fixed on the second branch pipeline 182 connected between the second injector 13 and the preparation bag 14;The pure water storage bag 15 is connected with the preparation bag 14 through the third branch pipeline 183, and two-way electromagnetic valves 17 are fixed on the third branch pipeline 183 connecting the pure water storage bag 15 and the preparation bag 14; the fourth branch pipeline 184 is fixed with a flow sensor 16 at the connection with the preparation bag 14.

[0071] The supplement device obtains the amount of the solvent entering the preparation bag 14 through the flow sensor 16, and the artificial kidney system calculates the required amount of the solid dissolved substance or the liquid dissolved substance concentrate to be supplemented according to the concentration of the dissolved substance in the target solution, and the supplement device realizes the injection of the dissolved substance in the first injector 12 and the second injector 13 into the preparation bag 14 by controlling the movement of the first motor 19 and the second motor 20.

[0072] Figure 4 and Figure 5 are respectively the detailed flow charts of two embodiments of the high-precision supplement algorithm for the dissolved substance in the circulating liquid provided by the application.

[0073] For example:

[0074] For the mixed addition of the solid dissolved substance and the pure water, the first circulating liquid preparation stage:

[0075] 1) the circulating liquid of 2000ml is set to be prepared, and the concentration of the dissolved substance is 2.5%;

[0076] 2) the concentration of the beneficial dissolved substance remaining in the liquid after the toxin removal is 1.53%, and the concentration after the nonlinear compensation is 1.55%;

[0077] 3) the initial liquid amount entering the preparation device is obtained through the high-precision flow sensor, which is 1800ml;

[0078] 4) the residual dissolved substance amount in the liquid is calculated as 1.55%*1800=27.9;

[0079] 5) the amount of the pure water to be supplemented is calculated as 2000-1800=200ml;

[0080] 6) the pure water is supplemented, and the actual liquid amount of the pure water supplement is obtained through the flow sensor, which is 197ml;

[0081] 7) the total liquid amount in the circulating liquid preparation device is calculated as 1800+197=1997ml;

[0082] 8) the total amount of the dissolved substance to be contained in the circulating liquid is calculated as 1997*2.5%=49.925;

[0083] 9) the amount of the dissolved substance to be supplemented is calculated as 49.925-27.9=22.025;

[0084] 10) the dissolved substance supplement operation is performed in the circulating liquid, and the circulating liquid is prepared;

[0085] 11) The concentration of dissolved substances in the prepared circulation fluid is 2.55%, The requirements for the concentration error σ = ± 0.2% are met, and the circulation fluid is prepared.

[0086] For the addition of a mixture of solid dissolved substances and pure water, the second circulation fluid preparation phase:

[0087] 1) Set the circulation fluid to be prepared to 2000 ml, and the concentration of dissolved substances to be 2.5%;

[0088] 2) The concentration of beneficial dissolved substances remaining in the toxin-removed liquid is 1.61%, and the concentration after nonlinear compensation is 1.59%;

[0089] 3) The initial liquid volume entering the preparation device is 1750 ml, which is obtained by a high-precision flow sensor,

[0090] 4) Calculate the residual dissolved substance in the liquid as 1.59% * 1750 = 27.825;

[0091] 5) Calculate the amount of pure water to be supplemented: 2000-1750 = 250 ml;

[0092] 6) Supplement pure water, and the actual liquid volume supplemented by the pure water is 246 ml, which is obtained by a flow sensor;

[0093] 7) Calculate the total liquid volume in the circulation fluid preparation device: 1750 + 246 = 1996 ml;

[0094] 8) Calculate the total amount of dissolved substances required in the circulation fluid: 1996 * 2.5% = 49.9;

[0095] 9) Calculate the amount of dissolved substances to be supplemented: 49.9-27.825 = 22.075;

[0096] 10) Supplement dissolved substances to the circulation fluid, and prepare the circulation fluid;

[0097] 11) The concentration of dissolved substances in the prepared circulation fluid is 2.15%, Not within the acceptable concentration error σ = ± 0.2%, continue to prepare the circulation fluid;

[0098] 12) Continue to supplement dissolved substances, and the amount of supplementation is 6.986;

[0099] 13) The concentration of dissolved substances in the prepared circulation fluid is 2.52%, The requirements for the concentration error σ = ± 0.2% are met, and the circulation fluid is prepared.

[0100] For the mixed addition of liquid solute concentrate and pure water, the first cycle liquid configuration stage:

[0101] 1) Set the required configuration of the circulating liquid 2000ml, solute concentration of 2.5%;

[0102] 2) The beneficial solute concentration remaining in the liquid after toxin removal is 1.54%, and the concentration after nonlinear compensation is 1.55%;

[0103] 3) The initial liquid quantity entering the configuration device is obtained by a high-precision flow sensor, which is 1500ml;

[0104] 4) The residual solute quantity in the liquid is calculated as 1.55%*1500 = 23.25;

[0105] 5) The solute supplement quantity is calculated as 2000*2.5%-23.25 = 26.75;

[0106] 6) The liquid solute concentrate concentration is 80%, and the required solute concentrate supplement quantity is calculated as 26.75 / 80% = 33.4375, the liquid concentration is supplemented, and the actual liquid quantity of solute concentrate supplement is obtained by a flow sensor, which is 33.5;

[0107] 7) The pure water supplement quantity is calculated as 2000-1500-33.5 = 466.5;

[0108] 8) The actual pure water supplement quantity is obtained by a flow sensor, which is 466ml

[0109] 9) The actual total supplement quantity is calculated as 1500+33.5+466 = 1999.5;

[0110] 10) The liquid solute concentrate and pure water mixed addition is completed, and the solute concentration after nonlinear compensation is measured as 2.51%, which meets the requirements within the acceptable concentration error σ = ±0.2%, and the cycle liquid configuration is completed.

[0111] For the mixed addition of liquid solute concentrate and pure water, the second cycle liquid configuration stage:

[0112] 1) Set the required configuration of the circulating liquid 2000ml, solute concentration of 2.5%;

[0113] 2) The beneficial solute concentration remaining in the liquid after toxin removal is 1.61%, and the concentration after nonlinear compensation is 1.60%;

[0114] 3) The initial liquid quantity entering the configuration device is obtained by a high-precision flow sensor, which is 1500ml;

[0115] 4) Calculate the residual dissolved mass in the liquid as 1.6% * 1500 = 24;

[0116] 5) Calculate the amount of dissolved substance to be replenished as 2000 * 2.5% - 24 = 26;

[0117] 6) The concentration of the liquid dissolved substance concentrate is 80%, calculate the amount of dissolved substance concentrate to be replenished as 26 / 80% = 32.5, replenish the liquid, and obtain the actual liquid amount replenished by the flow sensor as 26;

[0118] 7) Calculate the amount of pure water to be replenished as 2000 - 1500 - 30 = 470;

[0119] 8) Replenish the pure water, and obtain the actual amount of pure water replenished by the flow sensor as 465ml

[0120] 9) Calculate the actual total replenishment amount as 1500 + 30 + 465 = 1995;

[0121] 10) The liquid dissolved substance concentrate and pure water are mixed and added, and the measured nonlinear-compensated dissolved substance concentration is 2.25%, The dissolved substance concentration is too low;

[0122] 11) The dissolved substance replenishment operation needs to be continued, calculate the amount of liquid dissolved substance concentrate to be replenished as

[0123] 11) The liquid dissolved substance concentrate replenishment is completed, and the measured nonlinear-compensated dissolved substance concentration is 2.48%, It meets the requirements within the acceptable concentration error σ = ± 0.2% range, and the circulating liquid configuration is completed.

Claims

1. A method for augmenting the concentration of a circulating fluid solute, comprising: In the circulating liquid configuration stage, the mixed addition of solid solute and pure water, the mixed addition of liquid solute concentrate and pure water; For the mixed addition of solid solute and pure water, the following steps are included: Step 1: read the required configuration amount V of circulating liquid set , circulating liquid solute concentration ω set ; Step 2: Read the initial concentration of the solute in the liquid measured by the solute microsensor and obtain the concentration value ω after non-linear compensation f ; Step 3: Obtain the initial liquid volume V1 entering the configuration device through the flow sensor; Step 4: Calculate the dissolved substance content M1= ω f * V1; Step 5: Calculate the amount of pure water V to be replenished 水 = V set - V1; Step 6: Pure water supplement, and obtain the actual liquid volume V2 of the pure water supplement through the flow sensor; Step 7: Actual configuration cycle liquid total liquid volume is V 总 = V1+V2; Step 8: Calculate the total amount of dissolved substance M in the circulating liquid to be configured 总 = ω set * V 总 ; Step 9: Calculate the amount of dissolved substance M to be replenished 补 = M 总 - M1; Step 10: Solutes are replenished, the cycle liquid is configured, and the solute concentration after non-linear compensation is measured as ω New ; Step 11: calculating the difference between the value of the non-linearly compensated solute concentration and the set target circulating fluid concentration value determining and the acceptable solute concentration error σ: 1) if then step 14 is performed; 2) if If step 12 is performed, the solute concentration ω new Too high; 3) if If step 13 is performed, the solute concentration ω new is too low; Step 12: Solubility concentration ω new Too high, dilute with pure water, calculate water addition Carry out pure water replenishment, V 总 = V 总 + V 补 , proceed to Step 10; Step 13: solute concentration ω new Too low, continue solute supplement operation, calculate solute supplement amount M' 补 = (ω set - ω New )* V 总 , step 10; Step 14: The circulating liquid configuration is completed; For the mixed addition of liquid solute concentrate and pure water, the following steps are included: Step 1: read the required configuration amount V of circulating liquid set , circulating liquid solute concentration ω set ; Step 2: Read the initial concentration of the solute in the liquid measured by the solute microsensor and obtain the concentration value ω after non-linear compensation f ; Step 3: Obtain the initial liquid volume V1 entering the configuration device through the high-precision flow sensor; Step 4: Calculate the dissolved substance content M1= ω f *V1; Step 5: Calculate the amount of dissolved substance M to be replenished 补 = V set * ω set - M1; Step 6: Set the concentration ω of the liquid solute concentrate con , calculate the required solute concentrate replenishment V con = M 补 / ω con , and the actual liquid volume V2 of the solute concentrate supplement is obtained by the flow sensor; Step 7: Calculate the amount of pure water to be replenished V 水 = V set - V1-V2; Step 8: Pure water supplement, and obtain the actual pure water supplement volume V3 through the flow sensor; Step 9: Calculate the actual total replenishment amount V 总 = V1+V2+V3; Step 10: The liquid dissolvent concentrate and pure water are mixed and added to complete the measurement of the non-linear compensated dissolvent concentration ω New ; Step 11: calculating the difference between the value of the non-linearly compensated solute concentration and the set target circulating fluid concentration value determining and the acceptable solute concentration error σ: 1) if then step 14 is performed; 2) if If step 11 is performed, the solute concentration ω new Too high; 3) if If step 13 is performed, the solute concentration ω new is too low; Step 12: Solubility concentration ω new Too high, dilute with pure water, calculate water addition Carry out pure water replenishment, V' 总 = V 总 + V 补水 , proceed to Step 10; Step 13: solute concentration ω new Too low, continue solute supplement operation, calculate solute supplement amount Step 10 is performed; Step 14: The circulating liquid configuration is completed.

2. The algorithm for augmenting the concentration of a circulating fluid solute of claim 1, wherein: The acceptable solute concentration error σ is less than ±0.2%.

3. A device for replenishing the concentration of solute in a circulating fluid, used in a portable artificial kidney circulation system, characterized in that: In the circulating liquid configuration stage, the mixed addition of solid solute and pure water, and the mixed addition of liquid concentrate and pure water; the device includes a first motion execution mechanism (10), a second motion execution mechanism (11), a first syringe (12), a second syringe (13), a preparation bag (14), a pure water storage bag (15), a flow sensor (16), a two-way electromagnetic valve (17), a first branch pipeline (181), a second branch pipeline (182), a third branch pipeline (183), and a fourth branch pipeline (184); The first motion execution mechanism (10) includes a first motor (19), a first coupling (20), a first bearing (21), a first screw rod (22), a first sliding block (23), and a first fixed seat (24); the first motor (19) is fixed on the first fixed seat (24), the first coupling (20) is fixed on the first fixed seat (24) and connected with the output shaft of the first motor (19) and the first screw rod (22), the outer ring of the first bearing (21) is fixed on the first fixed seat (24), the inner ring is fixed on the end of the first screw rod (22), the first sliding block (23) is connected on the first screw rod (22) through internal threads, and the outside is in contact with the first fixed seat (24); when the first motor (19) drives the first screw rod (22) to rotate, the first sliding block (23) is restricted from moving back and forth along the direction of the first screw rod (22) due to the contact connection of the first fixed seat (24); The second motion executing mechanism (11) comprises a second motor (25), a second coupling (26), a second bearing (27), a second screw rod (28), a second sliding block (29) and a second fixed base (30); the second motor (25) is fixed on the second fixed base (30), the second coupling (26) is fixed on the second fixed base (30) and connected with the output shaft of the second motor (25) and the second screw rod (28), the outer ring of the second bearing (27) is fixed on the second fixed base (30) and the inner ring is fixed on the end of the second screw rod (28), the second sliding block (29) is connected with the second screw rod (28) through internal threads and connected with the second fixed base (30) externally; when the second motor (25) drives the second screw rod (28) to rotate, the second sliding block (29) is restricted to move back and forth along the direction of the second screw rod (28) due to the contact connection of the second fixed base (30); The first motion executing mechanism (10) is in a 90° direction with the second motion executing mechanism (11), the first fixed base (24) is fixedly connected with the second sliding block (29), when the second motor (25) rotates, the second sliding block (29) drives the first fixed base (24) to move up and down, so as to control the tail push rod of the first injector (12) or the second injector (13) to be clamped into the internal recessed structure of the first sliding block (23); the tail push rod of the first injector (12) and the second injector (13) is clamped into the internal recessed structure of the first sliding block (23), the first motion executing mechanism (10) drives the tail push rod of the first injector (12) and the second injector (13) to move back and forth through the control of the first sliding block (23), so as to control the injection of the substances in the first injector (12) and the second injector (13); the first injector (12) stores solid dissolvent in the inside, is connected with the preparation bag (14) through the first branch pipeline (181); the second injector (13) stores liquid dissolvent concentrate in the inside, is connected with the preparation bag (14) through the second branch pipeline (182); the first one-way valve (31) is fixed on the first branch pipeline (181), the second one-way valve (32) is fixed on the second branch pipeline (182); the pure water storage bag (15) is connected with the preparation bag (14) through the third branch pipeline (183), two-way electromagnetic valves (17) are fixed on the third branch pipeline (183); the flow sensor (16) is fixed on the fourth branch pipeline (184) connected with the preparation bag (14).

4. The apparatus of claim 3 wherein the means for increasing the concentration of the dissolved substance in the circulating liquid is a heat exchanger. The device comprises the supplementing algorithm of the dissolvent concentration of claim 1-2.

5. A portable artificial kidney characterized by: In the circulating liquid configuration stage, the mixed addition of solid elements and pure water and the mixed addition of liquid concentrate and pure water are included; the artificial kidney comprises the supplementing device of the circulating liquid dissolvent concentration of claim 3-4.

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