Clogging detection method and device

Abstract

The application relates to the field of blockage detection, and provides a blockage detection method and device. The method comprises the following steps: detecting the pressure in a pipeline between a first container and a peristaltic pump to obtain a first pressure; detecting the pressure in the pipeline between a second container and the peristaltic pump to obtain a second pressure; determining the flow direction of liquid in the pipeline according to the first pressure and the second pressure; and determining a blockage position according to the change trend of the first pressure, the change trend of the second pressure and the flow direction of the liquid in the pipeline. The blockage detection method provided by the embodiment of the application can determine the flow direction of the liquid in the pipeline by detecting the pressure at both ends of the peristaltic pump and the change trend thereof, and then determine the specific blockage position, that is, determine whether the first container is blocked, whether the second container is blocked or whether both the first container and the second container are blocked, so that targeted cleaning can be performed, the adverse influence of container blockage on cell separation work can be avoided, and the safety of separated samples can be ensured.

Description

Technical Field

[0001] The present application relates to the technical field of blockage detection, and in particular to a blockage detection method and device. Background Art

[0002] At present, cell therapy has become an emerging treatment method, among which cell separation methods play an important role in cell therapy. This method usually uses a centrifuge cup to separate mononuclear cells. During the separation process, the blood sample needs to be injected into the centrifuge cup, and the unnecessary liquid components need to be discharged from the centrifuge cup to the waste liquid bag, and the cleaning fluid in the cleaning bag needs to be discharged to the waste liquid bag to clean the circulation pipeline.

[0003] The flow of liquid is often achieved through a peristaltic pump. However, due to the different cell activities in the blood, blood clots or cell aggregation may occur. The products of cell aggregation or blood clots can cause blockage of the centrifuge cup or the blood sample bag, as well as the waste liquid bag. Impurities in the pipeline may also cause blockage of the cleaning bag. For operators, the blockage of the centrifuge cup will cause the safety risk of the cup exploding, rendering the entire centrifuge cup unusable; for pharmaceutical companies, the cup exploding will cause expensive blood samples to be unsalvageable; for patients, the cup exploding will lose their only hope of curing their lives; the blockage of the blood sample bag will cause the entire machine to idle and unable to operate normally; the blockage of the waste liquid bag will make it impossible to discharge unnecessary liquid components and the next step of the operation cannot be carried out; the blockage of the cleaning bag will result in insufficient cleaning of the pipeline, thereby increasing the risk of pipeline blockage. All of the above problems will greatly affect cell separation operations and sample safety. Summary of the Invention

[0004] The embodiments of the present application provide a blockage detection method and device to solve the technical problem that container blockage adversely affects cell separation work and sample safety.

[0005] In a first aspect, an embodiment of the present application provides a blockage detection method, comprising:

[0006] detecting the pressure in the pipeline between the first container and the peristaltic pump to obtain a first pressure;

[0007] detecting the pressure in the pipeline between the second container and the peristaltic pump to obtain a second pressure;

[0008] determining a flow direction of the liquid in the pipeline according to the first pressure and the second pressure;

[0009] The blockage position is determined according to the changing trend of the first pressure, the changing trend of the second pressure, and the flow direction of the liquid in the pipeline.

[0010] In one embodiment, determining the flow direction of the liquid in the pipeline according to the first pressure and the second pressure includes:

[0011] If the first pressure is negative, the second pressure is positive, and the absolute value of the difference between the first pressure and the second pressure is greater than a first difference threshold, it is confirmed that the first container is a sample bag, the second container is a centrifuge cup, and the liquid in the pipeline flows from the sample bag to the peristaltic pump, and then to the centrifuge cup.

[0012] In one embodiment, determining the blockage location based on the changing trend of the first pressure, the changing trend of the second pressure, and the flow direction of the liquid in the pipeline includes:

[0013] When the first container is a sample bag, the second container is a centrifuge cup, and the liquid in the pipeline flows from the sample bag to the peristaltic pump and then to the centrifuge cup:

[0014] If the change trend of the first pressure is a negative pressure decrease, the change trend of the second pressure is a negative pressure decrease, and the first pressure is less than or equal to a first negative pressure threshold, it is determined that the sample bag is blocked;

[0015] If the change trend of the first pressure is a positive pressure increase, the change trend of the second pressure is a positive pressure increase, and the second pressure is greater than or equal to a first positive pressure threshold, it is determined that the centrifuge cup is blocked;

[0016] If the changing trend of the first pressure is a negative pressure decrease, the changing trend of the second pressure is a positive pressure increase, and the first pressure is less than or equal to the first negative pressure threshold, or if the changing trend of the first pressure is a negative pressure decrease, the changing trend of the second pressure is a positive pressure increase, and the second pressure is greater than or equal to the first positive pressure threshold, it is confirmed that the sample bag and the centrifuge cup are blocked at the same time.

[0017] In one embodiment, determining the flow direction of the liquid in the pipeline according to the first pressure and the second pressure further includes:

[0018] If the first pressure is positive, the second pressure is negative, and the absolute value of the difference between the first pressure and the second pressure is less than a second difference threshold, it is confirmed that the first container is a waste liquid bag, the second container is a centrifuge cup, and the liquid in the pipeline flows from the centrifuge cup to the peristaltic pump and then to the waste liquid bag; the second difference threshold is less than the first difference threshold.

[0019] In one embodiment, determining the blockage location based on the changing trend of the first pressure, the changing trend of the second pressure, and the flow direction of the liquid in the pipeline includes:

[0020] When the first container is a waste liquid bag, the second container is a centrifuge cup, and the liquid in the pipeline flows from the centrifuge cup to the peristaltic pump and then to the waste liquid bag:

[0021] If the change trend of the first pressure is a negative pressure decrease, the change trend of the second pressure is a negative pressure decrease, and the second pressure is less than or equal to a second negative pressure threshold, it is determined that the centrifuge cup is blocked;

[0022] If the change trend of the first pressure is a positive pressure increase, the change trend of the second pressure is a positive pressure increase, and the first pressure is greater than or equal to a second positive pressure threshold, it is determined that the waste liquid bag is clogged;

[0023] If the changing trend of the first pressure is a positive pressure increase, the changing trend of the second pressure is a negative pressure decrease, and the first pressure is greater than or equal to the second positive pressure threshold, or if the changing trend of the first pressure is a positive pressure increase, the changing trend of the second pressure is a negative pressure decrease, and the second pressure is less than or equal to the second negative pressure threshold, it is confirmed that the waste liquid bag and the centrifuge cup are blocked at the same time.

[0024] In one embodiment, determining the flow direction of the liquid in the pipeline according to the first pressure and the second pressure further includes:

[0025] If the first pressure is positive pressure, the second pressure is negative pressure, the absolute value of the difference between the first pressure and the second pressure is greater than or equal to the second difference threshold, and the absolute value of the difference between the first pressure and the second pressure is less than or equal to the first difference threshold, then it is confirmed that the first container is a waste liquid bag, the second container is a cleaning bag, and the liquid in the pipeline flows from the cleaning bag to the peristaltic pump, and then flows to the waste liquid bag.

[0026] In one embodiment, determining the blockage location based on the changing trend of the first pressure, the changing trend of the second pressure, and the flow direction of the liquid in the pipeline includes:

[0027] When the first container is a waste liquid bag, the second container is a cleaning bag, and the liquid in the pipeline flows from the cleaning bag to the peristaltic pump and then to the waste liquid bag:

[0028] If the change trend of the first pressure is a negative pressure decrease, the change trend of the second pressure is a negative pressure decrease, and the second pressure is less than or equal to a third negative pressure threshold, it is determined that the cleaning bag is clogged;

[0029] If the change trend of the first pressure is a positive pressure increase, the change trend of the second pressure is a positive pressure increase, and the first pressure is greater than or equal to a third positive pressure threshold, it is determined that the waste liquid bag is clogged;

[0030] If the changing trend of the first pressure is a positive pressure increase, the changing trend of the second pressure is a negative pressure decrease, and the first pressure is greater than or equal to the third positive pressure threshold, or if the changing trend of the first pressure is a positive pressure increase, the changing trend of the second pressure is a negative pressure decrease, and the second pressure is less than or equal to the third negative pressure threshold, it is confirmed that the cleaning bag and the waste liquid bag are blocked at the same time.

[0031] In one embodiment, after determining the blockage location, the method includes:

[0032] The peristaltic pump is rotated in the reverse direction to backflush the pipeline.

[0033] In a second aspect, an embodiment of the present application provides a blockage detection device, comprising:

[0034] A first pressure detection module is used to detect the pressure in the pipeline between the first container and the peristaltic pump to obtain a first pressure;

[0035] A second pressure detection module is used to detect the pressure in the pipeline between the second container and the peristaltic pump to obtain a second pressure;

[0036] a liquid flow direction determination module, configured to determine the flow direction of the liquid in the pipeline according to the first pressure and the second pressure;

[0037] The blockage position determination module is used to determine the blockage position according to the change trend of the first pressure, the change trend of the second pressure and the flow direction of the liquid in the pipeline.

[0038] In a third aspect, an embodiment of the present application provides an electronic device, comprising a processor and a memory storing a computer program, wherein when the processor executes the program, the steps of the congestion detection method described in the first aspect are implemented.

[0039] The blockage detection method and device provided in the embodiment of the present application detects the pressure in the pipeline between the first container and the peristaltic pump to obtain a first pressure, detects the pressure in the pipeline between the second container and the peristaltic pump to obtain a second pressure, determines the flow direction of the liquid in the pipeline based on the first pressure and the second pressure, and determines the blockage location based on the changing trend of the first pressure, the changing trend of the second pressure, and the flow direction of the liquid in the pipeline. The present application first determines the flow direction of the liquid in the pipeline by detecting the pressure and its changing trend at both ends of the peristaltic pump, and then determines the specific blockage location, that is, whether it is the first container or the second container that is blocked, or both, and then can perform targeted cleaning to avoid the adverse effects of container blockage on cell separation work and ensure the safety of the separated samples. BRIEF DESCRIPTION OF THE DRAWINGS

[0040] In order to more clearly illustrate the technical solutions in the present application or the prior art, a brief introduction will be given below to the drawings required for use in the embodiments or the description of the prior art. Obviously, the drawings described below are some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without any creative work.

[0041] Figure 1 This is one of the flow charts of the blockage detection method provided in the embodiment of the present application;

[0042] Figure 2 This is a schematic diagram of a blood sample cell separation pipeline provided in an embodiment of the present application;

[0043] Figure 3 This is the second flow chart of the blockage detection method provided in the embodiment of the present application;

[0044] Figure 4 This is the third flow chart of the blockage detection method provided in the embodiment of the present application;

[0045] Figure 5 This is the fourth flow chart of the blockage detection method provided in the embodiment of the present application;

[0046] Figure 6 A schematic structural diagram of a blockage detection device provided in an embodiment of the present application;

[0047] Figure 7 It is a structural diagram of an electronic device provided in an embodiment of the present application. DETAILED DESCRIPTION

[0048] To make the objectives, technical solutions, and advantages of this application more clear, the technical solutions in this application will be clearly and completely described below in conjunction with the accompanying drawings in the embodiments of this application. Obviously, the described embodiments are only part of the embodiments of this application, not all of them. Based on the embodiments in this application, all other embodiments obtained by ordinary technicians in this field without making any creative efforts are within the scope of protection of this application.

[0049] Figure 1 This is one of the flow charts of the blockage detection method provided in the embodiment of the present application. Figure 1 , an embodiment of the present application provides a congestion detection method, which may include:

[0050] 101. Detecting the pressure in the pipeline between the first container and the peristaltic pump to obtain a first pressure;

[0051] In this step, the detection of the first pressure value is performed in real time.

[0052] 102. Detect the pressure in the pipeline between the second container and the peristaltic pump to obtain a second pressure;

[0053] In this step, the detection of the second pressure value is performed in real time.

[0054] 103. Determine the flow direction of the liquid in the pipeline according to the first pressure and the second pressure;

[0055] 104. Determine the blockage location based on the changing trend of the first pressure, the changing trend of the second pressure, and the flow direction of the liquid in the pipeline.

[0056] Pressure sensors can be set at both ends of the peristaltic pump. The pressure sensors can measure the pressure analog signal at the corresponding point in the pipeline. Through analog-to-digital conversion, the pressure analog signal is converted into a voltage digital value and transmitted to the control unit, which then determines whether the pressure in the pipe is abnormal.

[0057] The blockage detection method provided in this embodiment detects the pressure in the pipeline between a first container and a peristaltic pump to obtain a first pressure, and detects the pressure in the pipeline between a second container and the peristaltic pump to obtain a second pressure. Based on the first and second pressures, the flow direction of the liquid in the pipeline is determined, and the location of the blockage is determined based on the changing trends of the first and second pressures, the changing trends of the second pressure, and the flow direction of the liquid in the pipeline. This embodiment detects the pressure at both ends of the peristaltic pump and their changing trends to first determine the flow direction of the liquid in the pipeline, and then determines the specific location of the blockage, namely, whether it is the first container, the second container, or both that is blocked. This allows for targeted cleaning, avoiding the adverse effects of container blockage on cell separation and ensuring the safety of the separated samples.

[0058] It should be noted that the blood sample cell separation working state involved in this application is limited to:

[0059] 1. Separation working state, at this time the blood sample liquid flows from the sample bag to the separation cup;

[0060] 2. Waste liquid extraction working state, at this time the waste liquid flows from the centrifuge cup to the waste liquid bag;

[0061] 3. Pipeline cleaning state, at this time the cleaning liquid flows from the cleaning bag to the waste liquid bag.

[0062] The three states are switched by various valves provided in the pipeline, and therefore, flow routes other than these three liquid flow routes are not involved.

[0063] Figure 2 This is a schematic diagram of a blood sample cell separation pipeline provided in an embodiment of the present application, wherein pressure sensor 1 is used to detect a first pressure, and pressure sensor 2 is used to detect a second pressure.

[0064] Figure 3This is the second flow chart of the blockage detection method provided in the embodiment of the present application;

[0065] Reference Figure 2-3 In one embodiment, determining the flow direction of the liquid in the pipeline based on the first pressure and the second pressure, and determining the blockage location based on the changing trend of the first pressure, the changing trend of the second pressure, and the flow direction of the liquid in the pipeline may include:

[0066] 301. If the first pressure is negative, the second pressure is positive, and the absolute value of the difference between the first pressure and the second pressure is greater than a first difference threshold, then it is determined that the first container is a sample bag, the second container is a centrifuge cup, and the liquid in the pipeline flows from the sample bag to the peristaltic pump, and then to the centrifuge cup;

[0067] Among them, negative pressure refers to a gas pressure state lower than normal pressure (commonly known as one atmospheric pressure), and positive pressure refers to a gas pressure state higher than normal pressure (commonly known as one atmospheric pressure).

[0068] When the first pressure is negative and the second pressure is positive, it indicates that the peristaltic pump is extracting liquid from the first container, that is, the flow direction is from the first container to the second container. The absolute value of the difference between the first pressure and the second pressure is greater than the first difference threshold, indicating that the pressure difference between the first pressure and the second pressure is large. Since the pressure difference required to extract liquid from the bag to the cup is large, it can be determined that the first container is a sample bag and the second container is a centrifuge cup. The liquid in the pipeline flows from the sample bag to the peristaltic pump and then to the centrifuge cup.

[0069] 302. If the changing trend of the first pressure is a negative pressure decrease, the changing trend of the second pressure is a negative pressure decrease, and the first pressure is less than or equal to the first negative pressure threshold, it is determined that the sample bag is blocked;

[0070] When the blood in the blood sample bag is not shaken evenly, blood clots appear, and the liquid outlet of the blood sample bag is blocked, the internal pressure of the pipeline will gradually decrease due to the absence of liquid flow. If, within a preset time period, the first pressure is detected by pressure sensor 1 to continue to drop under negative pressure, and the second pressure is detected by pressure sensor 2 to drop from positive pressure to negative pressure, and continue to drop under negative pressure, so that the first pressure and the second pressure eventually show a trend of decreasing negative pressure, it can be preliminarily determined that there is a pipeline abnormality. Until the first pressure is less than or equal to the first negative pressure threshold, it is confirmed that the sample bag is blocked, and a prompt "abnormal internal pressure of the tube: negative pressure exceeds the standard" or "blood sample bag is blocked" may be displayed.

[0071] 303. If the change trend of the first pressure is a positive pressure increase, the change trend of the second pressure is a positive pressure increase, and the second pressure is greater than or equal to the first positive pressure threshold, it is determined that the centrifuge cup is blocked;

[0072] When the blood in the blood sample bag flows into the centrifuge cup or the centrifuge cup is injected with cell separation liquid during the centrifugation process, the liquid inlet channel of the centrifuge cup is blocked or the liquid inlet of the centrifuge cup is blocked, the blood sample continues to enter the pipeline but cannot flow into the centrifuge cup, which will cause the internal pressure of the pipeline to gradually increase. If, within a preset time period, the pressure sensor 1 detects that the first pressure rises from negative pressure to positive pressure and continues to rise under the positive pressure state, and the pressure sensor 2 detects that the second pressure continues to rise under the positive pressure state, so that the first pressure and the second pressure eventually show a positive pressure rising trend, it can be preliminarily judged that there is a pipeline abnormality. Until the second pressure is greater than or equal to the first positive pressure threshold, it is confirmed that the centrifuge cup is blocked, and a prompt "abnormal internal pressure of the tube: positive pressure exceeds the standard" or "liquid inlet of the centrifuge cup is blocked" may be displayed.

[0073] 304. If the changing trend of the first pressure is a negative pressure decrease, the changing trend of the second pressure is a positive pressure increase, and the first pressure is less than or equal to the first negative pressure threshold, or if the changing trend of the first pressure is a negative pressure decrease, the changing trend of the second pressure is a positive pressure increase, and the second pressure is greater than or equal to the first positive pressure threshold, it is confirmed that the sample bag and the centrifuge cup are blocked at the same time.

[0074] When both the blood sample bag and the centrifuge cup are blocked during the process of flowing into the centrifuge cup, the pressure in the pipe between the blood sample bag and the peristaltic pump gradually decreases, and the pressure in the pipe between the centrifuge cup and the peristaltic pump gradually increases. If, within a preset time period, the pressure sensor 1 detects that the first pressure continues to decrease under negative pressure, and the pressure sensor 2 detects that the second pressure continues to increase under positive pressure, it can be preliminarily determined that there is a pipeline abnormality. Until the first pressure is less than or equal to the first negative pressure threshold or the second pressure is greater than or equal to the first positive pressure threshold, it is confirmed that the sample bag and the centrifuge cup are blocked at the same time, and a prompt "Abnormal pressure in the pipe: positive / negative pressure exceeds the standard" or "The blood sample bag and the centrifuge cup are blocked at the same time" may be displayed.

[0075] This embodiment uses the first pressure and the second pressure to confirm that the liquid in the pipeline flows from the sample bag to the peristaltic pump and then to the centrifuge cup. It then confirms whether the blockage occurs in the sample bag, the centrifuge cup, or both based on the changing trends of the first pressure and the second pressure. It can identify the current working state as the separation working state and the type of blockage, which helps to subsequently perform targeted cleaning of blockages at different locations and improve the efficiency of the separation work.

[0076] Figure 4 This is the third flow chart of the blockage detection method provided in the embodiment of the present application;

[0077] Reference Figure 2 and 4In one embodiment, the flow direction of the liquid in the pipeline is determined based on the first pressure and the second pressure, and the blockage location is determined based on the change trend of the first pressure, the change trend of the second pressure, and the flow direction of the liquid in the pipeline. The method may also include:

[0078] 401. If the first pressure is positive, the second pressure is negative, and the absolute value of the difference between the first pressure and the second pressure is less than a second difference threshold, then it is determined that the first container is a waste liquid bag, the second container is a centrifuge cup, and the liquid in the pipeline flows from the centrifuge cup to the peristaltic pump, and then to the waste liquid bag;

[0079] The second difference threshold is smaller than the first difference threshold.

[0080] When the first pressure is positive and the second pressure is negative, it indicates that the peristaltic pump is extracting liquid from the second container, that is, the flow direction is from the second container to the first container. The absolute value of the difference between the first pressure and the second pressure is less than the second difference threshold and the second difference threshold is less than the first difference threshold, indicating that the pressure difference between the first pressure and the second pressure is small. Since the pressure difference required to extract liquid from the cup into the bag is small, it can be determined that the first container is a waste liquid bag and the second container is a centrifugal cup. The liquid in the pipeline flows from the centrifugal cup to the peristaltic pump and then to the waste liquid bag.

[0081] 402. If the changing trend of the first pressure is a negative pressure decrease, the changing trend of the second pressure is a negative pressure decrease, and the second pressure is less than or equal to a second negative pressure threshold, it is determined that the centrifuge cup is blocked;

[0082] When the liquid outlet of the centrifugal cup is blocked and the unnecessary liquid components (waste liquid) cannot be extracted, the internal pressure of the pipeline will gradually decrease due to the absence of liquid flow. If, within a preset time period, the first pressure is detected by pressure sensor 1 to drop from positive pressure to negative pressure and continues to drop under the negative pressure state, and the second pressure is detected by pressure sensor 2 to continue to drop under the negative pressure state, so that the first pressure and the second pressure eventually show a negative pressure drop trend, it can be preliminarily judged that there is a pipeline abnormality. Until the second pressure is less than or equal to the second negative pressure threshold, it is confirmed that the centrifugal cup is blocked, and a prompt "abnormal internal pressure of the tube: negative pressure exceeds the standard" or "liquid outlet of the centrifugal cup" may be prompted.

[0083] 403. If the change trend of the first pressure is a positive pressure increase, the change trend of the second pressure is a positive pressure increase, and the first pressure is greater than or equal to the second positive pressure threshold, it is determined that the waste liquid bag is clogged;

[0084] When the waste liquid bag is blocked or the switch of the waste liquid bag is not turned on, the unnecessary liquid component (waste liquid) cannot flow into the waste liquid bag. Since the waste liquid continues to enter the pipeline but cannot flow into the waste liquid bag, the internal pressure of the pipeline will gradually increase. If, within a preset time period, the first pressure is detected by pressure sensor 1 to continue to rise under positive pressure, and the second pressure is detected by pressure sensor 2 to rise from negative pressure to positive pressure and continue to rise under positive pressure, so that the first pressure and the second pressure finally show a trend of rising positive pressure, it can be preliminarily judged that there is a pipeline abnormality. Until the first pressure is greater than or equal to the second positive pressure threshold, it is confirmed that the waste liquid bag is blocked, and a prompt of "abnormal internal pressure of the pipeline: positive pressure exceeds the standard" or "waste liquid bag is blocked" is displayed.

[0085] 404. If the changing trend of the first pressure is a positive pressure increase, the changing trend of the second pressure is a negative pressure decrease, and the first pressure is greater than or equal to the second positive pressure threshold, or if the changing trend of the first pressure is a positive pressure increase, the changing trend of the second pressure is a negative pressure decrease, and the second pressure is less than or equal to the second negative pressure threshold, it is confirmed that the waste liquid bag and the centrifuge cup are blocked at the same time.

[0086] When the centrifuge cup and the waste liquid bag are blocked at the same time, the pressure in the pipe between the waste liquid bag and the peristaltic pump gradually increases, and the pressure in the pipe between the centrifuge cup and the peristaltic pump gradually decreases. If, within a preset time period, the pressure sensor 1 detects that the first pressure continues to rise under positive pressure, and the pressure sensor 2 detects that the second pressure continues to decrease under negative pressure, it can be preliminarily determined that there is a pipeline abnormality. Until the first pressure is greater than or equal to the second positive pressure threshold or the second pressure is less than or equal to the second negative pressure threshold, it is confirmed that the waste liquid bag and the centrifuge cup are blocked at the same time, and a prompt is given: "Abnormal pressure in the pipe: positive / negative pressure exceeds the standard" or "The centrifuge cup and the waste liquid bag are blocked at the same time."

[0087] This embodiment uses the first pressure and the second pressure to confirm that the liquid in the pipeline flows from the centrifuge cup to the peristaltic pump and then flows to the waste liquid bag. Then, based on the changing trends of the first pressure and the second pressure, it is confirmed whether the blockage occurs in the waste liquid bag, the centrifuge cup, or both. While identifying the current working state as the waste liquid extraction working state, it can also identify the type of blockage, which helps to subsequently perform targeted cleaning of blockages at different locations and improve the efficiency of waste liquid separation.

[0088] Figure 5 This is the fourth flow chart of the blockage detection method provided in the embodiment of the present application;

[0089] Reference Figure 2 and 5 In one embodiment, the flow direction of the liquid in the pipeline is determined based on the first pressure and the second pressure, and the blockage location is determined based on the change trend of the first pressure, the change trend of the second pressure, and the flow direction of the liquid in the pipeline. The method may also include:

[0090] 501. If the first pressure is positive, the second pressure is negative, the absolute value of the difference between the first pressure and the second pressure is greater than or equal to the second difference threshold, and the absolute value of the difference between the first pressure and the second pressure is less than or equal to the first difference threshold, then it is determined that the first container is a waste liquid bag and the second container is a cleaning bag, and the liquid in the pipeline flows from the cleaning bag to the peristaltic pump and then to the waste liquid bag;

[0091] When the first pressure is positive and the second pressure is negative, it indicates that the peristaltic pump is extracting liquid from the second container, that is, the flow direction is from the second container to the first container. The absolute value of the difference between the first pressure and the second pressure is greater than or equal to the second difference threshold, and the absolute value of the difference between the first pressure and the second pressure is less than or equal to the first difference threshold, indicating that the pressure difference between the first pressure and the second pressure is moderate. Since the pressure difference required to extract liquid from the bag into the bag is relatively moderate, it can be determined that the first container is a waste liquid bag and the second container is a cleaning bag. The liquid in the pipeline flows from the cleaning bag to the peristaltic pump and then to the waste liquid bag.

[0092] 502. If the change trend of the first pressure is a negative pressure decrease, the change trend of the second pressure is a negative pressure decrease, and the second pressure is less than or equal to the third negative pressure threshold, it is determined that the cleaning bag is clogged;

[0093] When the cleaning bag is clogged and the cleaning liquid cannot be extracted, the internal pressure of the pipeline will gradually decrease due to the lack of liquid flow. If, within a preset time period, the pressure sensor 1 detects that the first pressure drops from positive pressure to negative pressure and continues to drop under the negative pressure state, and the pressure sensor 2 detects that the second pressure continues to drop under the negative pressure state, so that the first pressure and the second pressure eventually show a trend of decreasing negative pressure, it can be preliminarily determined that there is a pipeline abnormality. Until the second pressure is less than or equal to the third negative pressure threshold, it is confirmed that the cleaning bag is clogged, and a prompt "Abnormal internal pressure of the pipeline: negative pressure exceeds the standard" or "Liquid outlet of the cleaning bag is blocked" may be displayed.

[0094] 503. If the change trend of the first pressure is a positive pressure increase, the change trend of the second pressure is a positive pressure increase, and the first pressure is greater than or equal to the third positive pressure threshold, it is determined that the waste liquid bag is clogged;

[0095] When the waste liquid bag is blocked or the switch of the waste liquid bag is not turned on, the unnecessary liquid component (waste liquid) cannot flow into the waste liquid bag. Since the waste liquid continues to enter the pipeline but cannot flow into the waste liquid bag, the internal pressure of the pipeline will gradually increase. If, within a preset time period, the first pressure is detected by pressure sensor 1 to continue to rise under positive pressure, and the second pressure is detected by pressure sensor 2 to rise from negative pressure to positive pressure and continue to rise under positive pressure, so that the first pressure and the second pressure finally show a trend of rising positive pressure, it can be preliminarily judged that there is a pipeline abnormality. Until the first pressure is greater than or equal to the third positive pressure threshold, it is confirmed that the waste liquid bag is blocked, and a prompt of "abnormal internal pressure of the pipeline: positive pressure exceeds the standard" or "waste liquid bag is blocked" is displayed.

[0096] 504. If the changing trend of the first pressure is a positive pressure increase, the changing trend of the second pressure is a negative pressure decrease, and the first pressure is greater than or equal to the third positive pressure threshold, or if the changing trend of the first pressure is a positive pressure increase, the changing trend of the second pressure is a negative pressure decrease, and the second pressure is less than or equal to the third negative pressure threshold, it is confirmed that the cleaning bag and the waste liquid bag are blocked at the same time.

[0097] When the cleaning bag and the waste liquid bag are blocked at the same time, the pressure in the pipeline between the waste liquid bag and the peristaltic pump gradually increases, and the pressure in the pipeline between the cleaning bag and the peristaltic pump gradually decreases. If, within a preset time period, the first pressure is detected by the pressure sensor 1 to continue to rise in a positive pressure state, and the second pressure is detected by the pressure sensor 2 to continue to decrease in a negative pressure state, it can be preliminarily determined that there is a pipeline abnormality. Until the first pressure is greater than or equal to the third positive pressure threshold or the second pressure is less than or equal to the third negative pressure threshold, it is confirmed that the waste liquid bag and the cleaning bag are blocked at the same time, and a prompt is given: "Abnormal pressure in the pipeline: positive / negative pressure exceeds the standard" or "The cleaning bag and the waste liquid bag are blocked at the same time."

[0098] This embodiment uses the first pressure and the second pressure to confirm that the liquid in the pipeline flows from the cleaning bag to the peristaltic pump and then flows to the waste liquid bag. It then confirms whether the blockage occurs in the waste liquid bag, the cleaning bag, or both based on the changing trends of the first pressure and the second pressure. It can identify the current working state as the pipeline cleaning working state and the type of blockage, which helps to subsequently carry out targeted cleaning of blockages in different locations and improve the efficiency of pipeline cleaning work.

[0099] In one embodiment, after determining the blockage location, the following steps may be performed:

[0100] Rotate the peristaltic pump in the reverse direction to backflush the pipeline. That is, if the peristaltic pump is currently in the forward state, adjust it to the reverse state to backflush the pipeline. If the peristaltic pump is currently in the reverse state, adjust it to the forward state to backflush the pipeline. The rotation direction can be adjusted repeatedly to improve the backflush effect.

[0101] This embodiment backflushes the pipeline by rotating the peristaltic pump in the reverse direction, which can apply an impact force to the blockage location and help clear the blockage.

[0102] The following describes a blockage detection device provided in an embodiment of the present application. The blockage detection device described below and the blockage detection method described above can refer to each other.

[0103] Figure 6 This is a schematic diagram of the structure of the blockage detection device provided in the embodiment of the present application. Figure 6 , an embodiment of the present application provides a blockage detection device, which may include:

[0104] A first pressure detection module 601 is configured to detect the pressure in the pipeline between the first container and the peristaltic pump to obtain a first pressure;

[0105] A second pressure detection module 602 is configured to detect the pressure in the pipeline between the second container and the peristaltic pump to obtain a second pressure;

[0106] a liquid flow direction determination module 603, configured to determine the flow direction of the liquid in the pipeline according to the first pressure and the second pressure;

[0107] The blockage position determination module 604 is configured to determine a blockage position according to a change trend of the first pressure, a change trend of the second pressure, and a flow direction of the liquid in the pipeline.

[0108] The blockage detection device provided in this embodiment detects the pressure in the pipeline between the first container and the peristaltic pump to obtain a first pressure, and detects the pressure in the pipeline between the second container and the peristaltic pump to obtain a second pressure. Based on the first and second pressures, the flow direction of the liquid in the pipeline is determined, and the location of the blockage is determined based on the changing trend of the first and second pressures, the changing trend of the second pressure, and the flow direction of the liquid in the pipeline. This embodiment detects the pressure at both ends of the peristaltic pump and its changing trend to first determine the flow direction of the liquid in the pipeline, and then determines the specific location of the blockage, that is, whether it is the first container, the second container, or both that is blocked. This allows for targeted cleaning, avoiding the adverse effects of container blockage on cell separation and ensuring the safety of the separated samples.

[0109] In one embodiment, the liquid flow direction determination module 603 is specifically configured to:

[0110] If the first pressure is negative, the second pressure is positive, and the absolute value of the difference between the first pressure and the second pressure is greater than a first difference threshold, it is confirmed that the first container is a sample bag, the second container is a centrifuge cup, and the liquid in the pipeline flows from the sample bag to the peristaltic pump, and then to the centrifuge cup.

[0111] In one embodiment, the blockage location determination module 604 is specifically configured to:

[0112] When the first container is a sample bag, the second container is a centrifuge cup, and the liquid in the pipeline flows from the sample bag to the peristaltic pump and then to the centrifuge cup:

[0113] If the change trend of the first pressure is a negative pressure decrease, the change trend of the second pressure is a negative pressure decrease, and the first pressure is less than or equal to a first negative pressure threshold, it is determined that the sample bag is blocked;

[0114] If the change trend of the first pressure is a positive pressure increase, the change trend of the second pressure is a positive pressure increase, and the second pressure is greater than or equal to a first positive pressure threshold, it is determined that the centrifuge cup is blocked;

[0115] If the changing trend of the first pressure is a negative pressure decrease, the changing trend of the second pressure is a positive pressure increase, and the first pressure is less than or equal to the first negative pressure threshold, or if the changing trend of the first pressure is a negative pressure decrease, the changing trend of the second pressure is a positive pressure increase, and the second pressure is greater than or equal to the first positive pressure threshold, it is confirmed that the sample bag and the centrifuge cup are blocked at the same time.

[0116] In one embodiment, the liquid flow direction determination module 603 is specifically configured to:

[0117] If the first pressure is positive, the second pressure is negative, and the absolute value of the difference between the first pressure and the second pressure is less than a second difference threshold, it is confirmed that the first container is a waste liquid bag, the second container is a centrifuge cup, and the liquid in the pipeline flows from the centrifuge cup to the peristaltic pump and then to the waste liquid bag; the second difference threshold is less than the first difference threshold.

[0118] In one embodiment, the blockage location determination module 604 is specifically configured to:

[0119] When the first container is a waste liquid bag, the second container is a centrifuge cup, and the liquid in the pipeline flows from the centrifuge cup to the peristaltic pump and then to the waste liquid bag:

[0120] If the change trend of the first pressure is a negative pressure decrease, the change trend of the second pressure is a negative pressure decrease, and the second pressure is less than or equal to a second negative pressure threshold, it is determined that the centrifuge cup is blocked;

[0121] If the change trend of the first pressure is a positive pressure increase, the change trend of the second pressure is a positive pressure increase, and the first pressure is greater than or equal to a second positive pressure threshold, it is determined that the waste liquid bag is clogged;

[0122] If the changing trend of the first pressure is a positive pressure increase, the changing trend of the second pressure is a negative pressure decrease, and the first pressure is greater than or equal to the second positive pressure threshold, or if the changing trend of the first pressure is a positive pressure increase, the changing trend of the second pressure is a negative pressure decrease, and the second pressure is less than or equal to the second negative pressure threshold, it is confirmed that the waste liquid bag and the centrifuge cup are blocked at the same time.

[0123] In one embodiment, the liquid flow direction determination module 603 is specifically configured to:

[0124] If the first pressure is positive pressure, the second pressure is negative pressure, and the absolute value of the difference between the first pressure and the second pressure is greater than or equal to the second difference threshold and less than or equal to the first difference threshold, it is confirmed that the first container is a waste liquid bag, the second container is a cleaning bag, and the liquid in the pipeline flows from the cleaning bag to the peristaltic pump, and then flows to the waste liquid bag.

[0125] In one embodiment, the blockage location determination module 604 is specifically configured to:

[0126] When the first container is a waste liquid bag, the second container is a cleaning bag, and the liquid in the pipeline flows from the cleaning bag to the peristaltic pump and then to the waste liquid bag:

[0127] If the change trend of the first pressure is a negative pressure decrease, the change trend of the second pressure is a negative pressure decrease, and the second pressure is less than or equal to a third negative pressure threshold, it is determined that the cleaning bag is clogged;

[0128] If the change trend of the first pressure is a positive pressure increase, the change trend of the second pressure is a positive pressure increase, and the first pressure is greater than or equal to a third positive pressure threshold, it is determined that the waste liquid bag is clogged;

[0129] If the changing trend of the first pressure is a positive pressure increase, the changing trend of the second pressure is a negative pressure decrease, and the first pressure is greater than or equal to the third positive pressure threshold, or if the changing trend of the first pressure is a positive pressure increase, the changing trend of the second pressure is a negative pressure decrease, and the second pressure is less than or equal to the third negative pressure threshold, it is confirmed that the cleaning bag and the waste liquid bag are blocked at the same time.

[0130] In one embodiment, a pipeline backflushing module (not shown) is further included, which is used to:

[0131] The peristaltic pump is rotated in the reverse direction to backflush the pipeline.

[0132] Figure 7 An example of a physical structure diagram of an electronic device is shown below. Figure 7As shown, the electronic device may include: a processor 710, a communication interface 720, a memory 730, and a communication bus 740, wherein the processor 710, the communication interface 720, and the memory 730 communicate with each other via the communication bus 740. The processor 710 may call a computer program in the memory 730 to execute the steps of the congestion detection method, for example, including:

[0133] detecting the pressure in the pipeline between the first container and the peristaltic pump to obtain a first pressure;

[0134] detecting the pressure in the pipeline between the second container and the peristaltic pump to obtain a second pressure;

[0135] determining a flow direction of the liquid in the pipeline according to the first pressure and the second pressure;

[0136] The blockage position is determined according to the changing trend of the first pressure, the changing trend of the second pressure, and the flow direction of the liquid in the pipeline.

[0137] In addition, the logic instructions in the above-mentioned memory 730 can be implemented in the form of a software functional unit and can be stored in a computer-readable storage medium when sold or used as an independent product. Based on this understanding, the technical solution of the present application is essentially or the part that contributes to the prior art or the part of the technical solution can be embodied in the form of a software product, and the computer software product is stored in a storage medium, including a number of instructions for enabling a computer device (which can be a personal computer, a server, or a network device, etc.) to execute all or part of the steps of the method described in each embodiment of the present application. The aforementioned storage medium includes: various media that can store program codes, such as a USB flash drive, a mobile hard disk, a read-only memory (ROM), a random access memory (RAM), a magnetic disk or an optical disk.

[0138] On the other hand, embodiments of the present application further provide a computer program product, comprising a computer program. The computer program may be stored on a non-transitory computer-readable storage medium. When the computer program is executed by a processor, the computer can perform the steps of the congestion detection method provided in the above embodiments, for example, including:

[0139] detecting the pressure in the pipeline between the first container and the peristaltic pump to obtain a first pressure;

[0140] detecting the pressure in the pipeline between the second container and the peristaltic pump to obtain a second pressure;

[0141] determining a flow direction of the liquid in the pipeline according to the first pressure and the second pressure;

[0142] The blockage position is determined according to the changing trend of the first pressure, the changing trend of the second pressure, and the flow direction of the liquid in the pipeline.

[0143] On the other hand, an embodiment of the present application further provides a processor-readable storage medium, wherein the processor-readable storage medium stores a computer program, wherein the computer program is configured to cause a processor to execute the steps of the methods provided in the above embodiments, for example, including:

[0144] detecting the pressure in the pipeline between the first container and the peristaltic pump to obtain a first pressure;

[0145] detecting the pressure in the pipeline between the second container and the peristaltic pump to obtain a second pressure;

[0146] determining a flow direction of the liquid in the pipeline according to the first pressure and the second pressure;

[0147] The blockage position is determined according to the changing trend of the first pressure, the changing trend of the second pressure, and the flow direction of the liquid in the pipeline.

[0148] The processor-readable storage medium can be any available medium or data storage device that can be accessed by the processor, including but not limited to magnetic storage (such as floppy disks, hard disks, magnetic tapes, magneto-optical disks (MO)), optical storage (such as CDs, DVDs, BDs, HVDs, etc.), and semiconductor storage (such as ROMs, EPROMs, EEPROMs, non-volatile memories (NANDFLASH), solid-state drives (SSDs)), etc.

[0149] The device embodiments described above are merely illustrative. The units described as separate components may or may not be physically separate, and the components shown as units may or may not be physical units, i.e., they may be located in one location or distributed across multiple network units. Some or all of the modules may be selected based on actual needs to achieve the objectives of the present embodiment. Persons of ordinary skill in the art will be able to understand and implement the present invention without inventive effort.

[0150] Through the description of the above embodiments, those skilled in the art can clearly understand that each embodiment can be implemented by means of software plus a necessary general hardware platform, or of course, by hardware. Based on this understanding, the essence of the above technical solution or the part that contributes to the existing technology can be embodied in the form of a software product. The computer software product can be stored in a computer-readable storage medium, such as ROM / RAM, a magnetic disk, an optical disk, etc., and includes a number of instructions for enabling a computer device (which can be a personal computer, a server, or a network device, etc.) to execute the methods described in each embodiment or certain parts of the embodiments.

[0151] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present application, rather than to limit them. Although the present application has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or make equivalent replacements for some of the technical features therein. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the embodiments of the present application.

Claims

1. A blockage detection method, characterized in that: include: detecting the pressure in the pipeline between the first container and the peristaltic pump to obtain a first pressure; detecting the pressure in the pipeline between the second container and the peristaltic pump to obtain a second pressure; Determining a flow direction of the liquid in the pipeline according to the first pressure and the second pressure includes: If the first pressure is negative, the second pressure is positive, and the absolute value of the difference between the first pressure and the second pressure is greater than a first difference threshold, it is determined that the first container is a sample bag, the second container is a centrifuge cup, and the liquid in the pipeline flows from the sample bag to the peristaltic pump and then to the centrifuge cup; If the first pressure is positive, the second pressure is negative, and the absolute value of the difference between the first pressure and the second pressure is less than a second difference threshold, it is determined that the first container is a waste liquid bag, the second container is a centrifuge cup, and the liquid in the pipeline flows from the centrifuge cup to the peristaltic pump and then to the waste liquid bag; and the second difference threshold is less than the first difference threshold; If the first pressure is positive, the second pressure is negative, the absolute value of the difference between the first pressure and the second pressure is greater than or equal to the second difference threshold, and the absolute value of the difference between the first pressure and the second pressure is less than or equal to the first difference threshold, then it is determined that the first container is a waste liquid bag, the second container is a cleaning bag, and the liquid in the pipeline flows from the cleaning bag to the peristaltic pump, and then flows to the waste liquid bag; The blockage position is determined according to the changing trend of the first pressure, the changing trend of the second pressure, and the flow direction of the liquid in the pipeline.

2. The congestion detection method according to claim 1, characterized in that: The determining of the blockage location according to the changing trend of the first pressure, the changing trend of the second pressure, and the flow direction of the liquid in the pipeline includes: When the first container is a sample bag, the second container is a centrifuge cup, and the liquid in the pipeline flows from the sample bag to the peristaltic pump and then to the centrifuge cup: If the change trend of the first pressure is a negative pressure decrease, the change trend of the second pressure is a negative pressure decrease, and the first pressure is less than or equal to a first negative pressure threshold, it is determined that the sample bag is blocked; If the change trend of the first pressure is a positive pressure increase, the change trend of the second pressure is a positive pressure increase, and the second pressure is greater than or equal to a first positive pressure threshold, it is determined that the centrifuge cup is blocked; If the changing trend of the first pressure is a negative pressure decrease, the changing trend of the second pressure is a positive pressure increase, and the first pressure is less than or equal to the first negative pressure threshold, or if the changing trend of the first pressure is a negative pressure decrease, the changing trend of the second pressure is a positive pressure increase, and the second pressure is greater than or equal to the first positive pressure threshold, it is confirmed that the sample bag and the centrifuge cup are blocked at the same time.

3. The blockage detection method according to claim 1, wherein: The determining of the blockage location according to the changing trend of the first pressure, the changing trend of the second pressure, and the flow direction of the liquid in the pipeline includes: When the first container is a waste liquid bag, the second container is a centrifuge cup, and the liquid in the pipeline flows from the centrifuge cup to the peristaltic pump and then to the waste liquid bag: If the change trend of the first pressure is a negative pressure decrease, the change trend of the second pressure is a negative pressure decrease, and the second pressure is less than or equal to a second negative pressure threshold, it is determined that the centrifuge cup is blocked; If the change trend of the first pressure is a positive pressure increase, the change trend of the second pressure is a positive pressure increase, and the first pressure is greater than or equal to a second positive pressure threshold, it is determined that the waste liquid bag is clogged; If the changing trend of the first pressure is a positive pressure increase, the changing trend of the second pressure is a negative pressure decrease, and the first pressure is greater than or equal to the second positive pressure threshold, or if the changing trend of the first pressure is a positive pressure increase, the changing trend of the second pressure is a negative pressure decrease, and the second pressure is less than or equal to the second negative pressure threshold, it is confirmed that the waste liquid bag and the centrifuge cup are blocked at the same time.

4. The blockage detection method according to claim 1, wherein: The determining of the blockage location according to the changing trend of the first pressure, the changing trend of the second pressure, and the flow direction of the liquid in the pipeline includes: When the first container is a waste liquid bag, the second container is a cleaning bag, and the liquid in the pipeline flows from the cleaning bag to the peristaltic pump and then to the waste liquid bag: If the change trend of the first pressure is a negative pressure decrease, the change trend of the second pressure is a negative pressure decrease, and the second pressure is less than or equal to a third negative pressure threshold, it is determined that the cleaning bag is clogged; If the change trend of the first pressure is a positive pressure increase, the change trend of the second pressure is a positive pressure increase, and the first pressure is greater than or equal to a third positive pressure threshold, it is determined that the waste liquid bag is clogged; If the changing trend of the first pressure is a positive pressure increase, the changing trend of the second pressure is a negative pressure decrease, and the first pressure is greater than or equal to the third positive pressure threshold, or if the changing trend of the first pressure is a positive pressure increase, the changing trend of the second pressure is a negative pressure decrease, and the second pressure is less than or equal to the third negative pressure threshold, it is confirmed that the cleaning bag and the waste liquid bag are blocked at the same time.

5. The blockage detection method according to claim 1, wherein: After determining the blockage location, the method includes: The peristaltic pump is rotated in the reverse direction to backflush the pipeline.

6. A blockage detection device, characterized in that: The method for performing the blockage detection method according to claim 1 comprises: A first pressure detection module is used to detect the pressure in the pipeline between the first container and the peristaltic pump to obtain a first pressure; A second pressure detection module is used to detect the pressure in the pipeline between the second container and the peristaltic pump to obtain a second pressure; a liquid flow direction determination module, configured to determine the flow direction of the liquid in the pipeline according to the first pressure and the second pressure; The blockage position determination module is used to determine the blockage position according to the change trend of the first pressure, the change trend of the second pressure and the flow direction of the liquid in the pipeline.

7. An electronic device comprising a processor and a memory storing a computer program, characterized in that: When the processor executes the computer program, the steps of the congestion detection method according to any one of claims 1 to 5 are implemented.

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