A tumor tissue sampling pen

Abstract

This invention discloses a tumor tissue sampling pen, relating to the field of medical devices. The tumor tissue sampling pen includes a tissue cutting assembly, a rotating assembly, and a push rod assembly. The tissue cutting assembly includes a blade holder and a blade assembly, with the blade assembly disposed at one end of the blade holder. The rotating assembly includes a pen body mechanism, a rotating mechanism, and a connecting rod. Both the rotating mechanism and the connecting rod are disposed within the pen body mechanism. The rotating mechanism further includes a pen cap, a guide sleeve, and a rotating column. The pen cap and the rotating column are connected via the guide sleeve, and the end of the rotating column away from the guide sleeve abuts against one end of the connecting rod. The push rod assembly includes a thumb pressing part, a push rod, an elastic limiting member, a first elastic member, and a push sleeve. The elastic limiting member is disposed on the push rod near the thumb pressing part, the first elastic member and the push rod abut against each other, and the end of the push rod away from the thumb pressing part is connected to the push sleeve. By replacing different tissue cutting assemblies and push sleeves, the size of the tumor tissue block to be cut can be adjusted.

Description

Technical Field

[0001] This invention relates to the field of medical devices, and more specifically, to a tumor tissue sampling pen. Background Technology

[0002] Because tumors are heterogeneous, different patients' tumors respond differently to different drugs. Three-dimensional culture can detect drug sensitivity in ex vivo tumor tissue, thereby developing individualized chemotherapy and adjuvant therapy plans, achieving individualized, precise, and targeted treatment, and improving patients' clinical prognosis.

[0003] One method for drug sensitivity testing using ex vivo tumor tissue involves partially removing the surgically separated tumor, cutting the removed tumor tissue into several parts using a scalpel or surgical scissors, inoculating them into culture dishes for in vitro culture, adding different drugs after a period of culture, and then testing the drug sensitivity of the tumor tissue.

[0004] After obtaining tumor tissue, a common method for dividing the tumor tissue is to use a double-blade cutting method to separate the tissue, and then use forceps to pick up the cut tissue blocks and place them in a culture dish for culture. The double-blade cutting method for separating tumors is cumbersome, and the tumor tissue obtained is irregular in size and shape, which can easily cause damage to the tumor tissue during the cutting process. After the cutting is completed, the tissue blocks still need to be inoculated into a culture dish with forceps.

[0005] CN215778264U discloses a biopsy needle for easy tissue cutting. The biopsy needle includes a needle hub and a needle body. The needle hub has an internal cavity with grooves on both sides. A lifting frame is slidably connected inside the cavity, and sliders are welded to both sides of the lifting frame. The needle body is connected to the bottom of the needle hub by screws. A sampling head is slidably connected to the bottom of the needle body. An annular groove is formed on the outer circumference of the sampling head, and an annular blade is welded to the outer side of the bottom surface inside the annular groove. A sliding rod is welded to the upper surface of the sampling head, and a rotating handle is threaded to the top of the sliding rod. Through the cooperation of the needle body and the sampling head, tissue can be easily and quickly cut and sampled. During tissue cutting, the rotating handle can be turned to rotate the sampling head, and the annular blade on the sampling head rotates synchronously, thus facilitating tissue cutting. However, this tissue biopsy instrument is not convenient to carry around, it is difficult to adjust the size of the tumor to be cut, and the instrument is usually quite long. Generally, one hand is needed to hold the instrument and the other hand to activate the cutting button to cut and obtain tissue samples. It is difficult to hold and cut the instrument with one hand. Summary of the Invention

[0006] The purpose of this invention is to provide a tumor tissue sampling pen, which is mainly used for sampling excised tumor tissue, and can also be used for biopsies of tumors on the skin or body surface. The sampled tumors are of uniform size, regular shape, and adjustable size.

[0007] The purpose of this invention is to provide a tumor tissue sampling pen that can reduce the workload in the drug sensitivity testing process and improve the accuracy of drug sensitivity testing, so that the test results can better reflect the patient's tumor response to different drugs, thereby enabling better individualized chemotherapy and adjuvant therapy plans for patients, and ultimately achieving individualized precision treatment and targeted therapy to improve the patient's clinical prognosis.

[0008] The embodiments of the present invention are implemented as follows:

[0009] This application provides a tumor tissue sampling pen, which includes: a tissue cutting component, a rotating component, and a push rod component.

[0010] The aforementioned tissue cutting assembly includes a blade holder and a blade assembly, with the blade assembly disposed at one end of the blade holder.

[0011] The aforementioned rotating assembly includes a pen body mechanism, a rotating mechanism, and a connecting rod; the rotating mechanism and the connecting rod are both disposed within the pen body mechanism; the rotating mechanism further includes a pen cap, a guide sleeve, and a rotating column; the pen cap and the rotating column are connected through the guide sleeve; and the end of the rotating column away from the guide sleeve abuts against one end of the connecting rod.

[0012] The aforementioned push rod assembly includes a thumb pressing portion, a push rod, an elastic limiting member, a first elastic member, and a push sleeve; the elastic limiting member is disposed on the push rod near the end of the thumb pressing portion, the first elastic member and the push rod abut against each other, and the end of the push rod away from the thumb pressing portion is connected to the push sleeve.

[0013] In some embodiments of the present invention, the pen body mechanism includes a pen body, a pen clip, and a first groove disposed along the axial direction of the pen body. The pen body is sequentially provided with a first stepped hole, a second stepped hole, a third stepped hole, and a fourth stepped hole coaxial with the pen body; the pen clip is disposed on the pen body at one end near the first stepped hole; and a second groove is also provided on the first groove near the pen clip.

[0014] In some embodiments of the present invention, the pen cap further includes a pressing part, a pen cap sleeve, a sheet-like protrusion, and protruding teeth; the outer diameter of the pen cap sleeve is the same as the diameter of the first stepped hole, and the pen cap sleeve is disposed in the first stepped hole; the protruding teeth are uniformly disposed circumferentially on the pen cap sleeve at the end away from the pressing part; the sheet-like protrusion is uniformly disposed circumferentially on the pen cap sleeve at the end near the protruding teeth.

[0015] In some embodiments of the present invention, the outer diameter of the guide sleeve is the same as the diameter of the second stepped hole, and the rotating column and the guide sleeve are disposed in the second stepped hole; the diameter of the connecting rod is the same as the diameter of the third stepped hole, the connecting rod is disposed in the third stepped hole, one end of the connecting rod abuts against the end of the rotating column away from the guide sleeve, and the end of the connecting rod away from the rotating column is threadedly connected to the end of the tool holder away from the blade assembly.

[0016] In some embodiments of the present invention, the diameter of the aforementioned tool holder is the same as the diameter of the aforementioned fourth stepped hole, and the aforementioned tool holder is disposed within the aforementioned fourth stepped hole. A second elastic member is also provided on the aforementioned tool holder, one end of which abuts against the end connecting the aforementioned tool holder and the aforementioned connecting rod, and the other end of which abuts against the stepped surface of the aforementioned third stepped hole.

[0017] In some embodiments of the present invention, a first protrusion is provided at one end of the pen clip, and a first square hole and a second square hole adapted to the first protrusion are provided near the pen clip end of the pen body; a second protrusion adapted to the first square hole and the second square hole is also provided on the elastic limiting member.

[0018] In some embodiments of the present invention, the push rod is disposed in the first groove, and the elastic limiting member is disposed on the push rod near the pen clip end; the push rod near the pen clip end is also provided with a third groove adapted to the second groove, and the first elastic member is disposed in the second groove and the third groove; the push rod away from the thumb pressing part is also provided with a third shaped hole.

[0019] In some embodiments of the present invention, a fifth stepped hole and a sixth stepped hole, coaxial with the push sleeve, are sequentially provided inside the push sleeve; the inner diameter of the fifth stepped hole is the same as the outer diameter of the end of the pen body with the fourth stepped hole, and the inner diameter of the sixth stepped hole is the same as the diameter of the knife rod. The push sleeve is fitted onto the end of the pen body with the fourth stepped hole. One end of the push sleeve is a conical surface, and the end of the push sleeve away from the conical surface is provided with a third protrusion and a fourth protrusion adapted to the third triangular hole. The third protrusion is provided with an inclined surface; the end of the push sleeve away from the conical surface is connected to the end of the push rod with the third triangular hole.

[0020] In some embodiments of the present invention, the guide sleeve is uniformly provided with a plurality of guide posts in the circumferential direction, the distance between two adjacent guide posts is the same as the width of the sheet-like protrusion, and the inner wall of the plurality of guide posts is provided with a fourth groove that matches the sheet-like protrusion; one end of the guide post is provided with a stepped tooth.

[0021] In some embodiments of the present invention, the rotating column includes a first rotating column, a second rotating column, and a plate-like body. The diameter of the first rotating column is the same as the inner diameter of the pen cap sleeve, the diameter of the second rotating column is the same as the diameter of the second stepped hole, and the plate-like body is uniformly arranged circumferentially along the stepped surface connecting the first rotating column and the second rotating column. The width of the plate-like body is the same as the distance between two adjacent guide columns. One end of the plate-like body is provided with an inclined surface that is adapted to both the protruding teeth and the stepped teeth.

[0022] Compared with the prior art, the embodiments of the present invention have at least the following advantages or beneficial effects:

[0023] This tumor tissue sampling pen is portable (slightly larger than a regular pen, about the size of a pipette), easy to operate, quick and convenient sampling, can be operated with one hand to cut tumor tissue, produces tumor tissue of uniform size and shape, and can increase the accuracy of drug sensitivity testing. The size of the tumor tissue sample can be adjusted by changing different tissue cutting components and the push sleeve. Attached Figure Description

[0024] To more clearly illustrate the technical solutions of the embodiments of the present invention, the accompanying drawings used in the embodiments will be briefly introduced below. It should be understood that the following drawings only show some embodiments of the present invention and should not be regarded as a limitation on the scope. For those skilled in the art, other related drawings can be obtained based on these drawings without creative effort.

[0025] The structures, proportions, sizes, etc. illustrated in this specification are only for the purpose of assisting those skilled in the art in understanding and reading the content disclosed herein, and are not intended to limit the conditions under which the present invention can be implemented. Therefore, they have no substantial technical significance. Any modifications to the structure, changes in the proportions, or adjustments to the size, without affecting the effects and objectives that the present invention can produce, should still fall within the scope of the technical content disclosed in the present invention.

[0026] Figure 1 This is a schematic diagram of the overall structure of the tumor tissue sampling pen provided in an embodiment of the present invention;

[0027] Figure 2 This is a cross-sectional view of the assembly of the tumor tissue sampling pen provided in an embodiment of the present invention;

[0028] Figure 3 This is a cross-sectional view of the pen body structure of the tumor tissue sampling pen provided in an embodiment of the present invention;

[0029] Figure 4 A schematic diagram of the pen cap structure of a tumor tissue sampling pen provided in an embodiment of the present invention;

[0030] Figure 5 A schematic diagram of the guide sleeve structure of the tumor tissue sampling pen provided in an embodiment of the present invention;

[0031] Figure 6 A schematic diagram of the rotating column structure of the tumor tissue sampling pen provided in an embodiment of the present invention;

[0032] Figure 7 This is a schematic diagram of the pen cap, guide sleeve, and rotating column assembly of a tumor tissue sampling pen provided in an embodiment of the present invention.

[0033] Figure 8 This is a cross-sectional view of the linkage structure of the tumor tissue sampling pen provided in an embodiment of the present invention;

[0034] Figure 9 A schematic diagram of the tissue cutting component structure of the tumor tissue sampling pen provided in an embodiment of the present invention;

[0035] Figure 10 A schematic diagram of the push rod structure of the tumor tissue sampling pen provided in an embodiment of the present invention;

[0036] Figure 11 This is a schematic diagram of the cross-sectional structure of the push sleeve of the tumor tissue sampling pen provided in an embodiment of the present invention.

[0037] Icons: 1-Tissue cutting assembly; 11-Blade holder; 111-Second elastic element; 12-Blade assembly; 2-Rotating assembly; 21-Pen body mechanism; 211-Pen body; 212-Pen clip; 2121-First protrusion; 213-First groove; 214-Second groove; 215-First stepped hole; 216-Second stepped hole; 217-Third stepped hole; 218-Fourth stepped hole; 219-First square hole; 2110-Second square hole; 22-Rotating mechanism; 221-Pen cap; 2211-Pressing part; 2212-Pen cap sleeve; 2213-Sheet-like protrusion; 22 14-Protruding tooth; 222-Guide sleeve; 2221-Guide post; 2222-Fourth groove; 2223-Stepped tooth; 223-Rotating post; 2231-First rotating post; 2232-Second rotating post; 2233-Sheet-like body; 23-Connecting rod; 3-Push rod assembly; 31-Thumb pressing part; 32-Push rod; 33-Elastic limiting rod; 331-Second protrusion; 34-First elastic element; 35-Third groove; 36-Third triangular hole; 37-Push sleeve; 371-Fifth stepped hole; 372-Sixth stepped hole; 373-Third protrusion; 374-Fourth protrusion. Detailed Implementation

[0038] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. The components of the embodiments of the present invention described and shown in the accompanying drawings can generally be arranged and designed in various different configurations.

[0039] Therefore, the following detailed description of the embodiments of the invention provided in the accompanying drawings is not intended to limit the scope of the claimed invention, but merely to illustrate selected embodiments of the invention. All other embodiments obtained by those skilled in the art based on the embodiments of the invention without inventive effort are within the scope of protection of the invention.

[0040] It should be noted that similar labels and letters in the following figures indicate similar items. Therefore, once an item is defined in one figure, it does not need to be further defined and explained in subsequent figures.

[0041] Example

[0042] Please refer to Figures 1-11 , Figure 1 This is a schematic diagram of the overall structure of the tumor tissue sampling pen provided in an embodiment of the present invention; Figure 2 This is a cross-sectional view of the assembly of the tumor tissue sampling pen provided in an embodiment of the present invention; Figure 3This is a cross-sectional view of the pen body structure of the tumor tissue sampling pen provided in an embodiment of the present invention; Figure 4 A schematic diagram of the pen cap structure of a tumor tissue sampling pen provided in an embodiment of the present invention; Figure 5 A schematic diagram of the guide sleeve structure of the tumor tissue sampling pen provided in an embodiment of the present invention; Figure 6 A schematic diagram of the rotating column structure of the tumor tissue sampling pen provided in an embodiment of the present invention; Figure 7 This is a schematic diagram of the pen cap, guide sleeve, and rotating column assembly of a tumor tissue sampling pen provided in an embodiment of the present invention. Figure 8 A schematic diagram of the connecting rod structure of the tumor tissue sampling pen provided in an embodiment of the present invention; Figure 9 A schematic diagram of the tissue cutting component structure of the tumor tissue sampling pen provided in an embodiment of the present invention; Figure 10 A schematic diagram of the push rod structure of the tumor tissue sampling pen provided in an embodiment of the present invention; Figure 11 This is a schematic diagram of the cross-sectional structure of the push sleeve of the tumor tissue sampling pen provided in an embodiment of the present invention.

[0043] This embodiment provides a tumor tissue sampling pen, which includes a tissue cutting component 1, a rotating component 2, and a push rod component 3.

[0044] The tissue cutting assembly 1 includes a blade holder 11 and a blade assembly 12, with the blade assembly 12 disposed at one end of the blade holder 11.

[0045] The rotating assembly 2 includes a pen body mechanism 21, a rotating mechanism 22, and a connecting rod 23. Both the rotating mechanism 22 and the connecting rod 23 are installed inside the pen body mechanism 21. The rotating mechanism 22 may also include a pen cap 221, a guide sleeve 222, and a rotating column 223. The pen cap 221 and the rotating column 223 are connected through the guide sleeve 222. The end of the rotating column 223 away from the guide sleeve 222 abuts against one end of the connecting rod 23.

[0046] In this embodiment, the pen body mechanism 21 may further include a pen body 211, a pen clip 212, a first groove 213, a second groove 214, a first stepped hole 215, a second stepped hole 216, a third stepped hole 217, a fourth stepped hole 218, a first square hole 219, and a second square hole 2110.

[0047] Understandably, the pen body has holes of different diameters along the axial direction to facilitate the installation of different parts.

[0048] The push rod assembly 3 includes a thumb pressing part 31, a push rod 32, an elastic limiting rod 33, a second elastic element 111, a third groove 35, a third triangular hole 36, and a push sleeve 37. The elastic limiting rod 33 is also provided with a second protrusion 331.

[0049] In this embodiment, the pen cap 221 also includes a spherical pressing part 2211, a pen cap sleeve 2212, eight sheet-like protrusions 2213 and protruding teeth 2214.

[0050] In this embodiment, the outer diameter of the pen cap sleeve 2212 is the same as the diameter of the first stepped hole 215. The pen cap sleeve 2212 is installed in the first stepped hole 215. The protruding teeth 2214 are evenly arranged on the pen cap sleeve 2212 around the end away from the pressing part 2211. The plate-shaped protrusions 2213 are evenly arranged on the pen cap sleeve 2212 around the end near the protruding teeth 2214.

[0051] In this embodiment, the guide sleeve 222 is uniformly designed with four guide posts 2221 around its circumference. The distance between two adjacent guide posts 2221 is the same as the width of the sheet-like protrusion 2213. The inner wall of each guide post 2221 is designed with a fourth groove 2222 that matches the sheet-like protrusion 2213. One end of the guide post 2221 is designed with stepped teeth 2223.

[0052] It should be noted that the inner diameter of the fourth groove 2222 is the same as the outer diameter of the sheet-like protrusion 2213.

[0053] In this embodiment, the rotating column 223 includes a first rotating column 2231, a second rotating column 2232, and four plate-like bodies 2233. The diameter of the first rotating column 2231 is the same as the inner diameter of the pen cap sleeve 2212, the diameter of the second rotating column 2232 is the same as the diameter of the second stepped hole 216, and the plate-like bodies 2233 are uniformly arranged circumferentially along the stepped surface connecting the first rotating column 2231 and the second rotating column 2232. The width of the plate-like bodies 2233 is the same as the distance between two adjacent guide columns 2221. One end of the plate-like bodies 2233 is designed with an inclined surface that is adapted to both the protruding teeth 2214 and the stepped teeth 2223.

[0054] It should be noted that after the tumor tissue sampling assembly is completed, the first rotating column 2231 is installed inside the pen cap sleeve 2212.

[0055] In this embodiment, the outer diameter of the guide sleeve 222 is the same as the diameter of the second stepped hole 216, and the rotating column 223 and the guide sleeve 222 are installed in the second stepped hole 216; the diameter of the connecting rod 23 is the same as the diameter of the third stepped hole 217, and the connecting rod 23 is installed in the third stepped hole 217, with one end of the connecting rod 23 abutting against the end of the rotating column 223 away from the guide sleeve 222.

[0056] It is understandable that the purpose of designing the rotating component 2 in this structure is to realize the function of rotating the rotating column 223.

[0057] In this embodiment, the end of the connecting rod 23 away from the rotating column 223 is machined with a threaded hole coaxial with the connecting rod 23, and the end of the tool holder 11 away from the blade assembly 12 is machined with an external thread that matches the threaded hole on the connecting rod 23. The end of the connecting rod 23 with the threaded hole and the end of the tool holder 11 with the external thread are connected by threads.

[0058] Understandably, the connection between the connecting rod 23 and the tool holder 11 uses a common threaded connection, which is convenient for manufacturing and assembly / disassembly.

[0059] In this embodiment, the diameter of the tool holder 11 is the same as the diameter of the fourth stepped hole 218, and the tool holder 11 is installed inside the fourth stepped hole 218. A second elastic element 111 is also sleeved on the tool holder 11. One end of the second elastic element 111 abuts against the end where the tool holder 11 is connected to the connecting rod 23, and the other end of the second elastic element 111 abuts against the stepped surface of the third stepped hole 217.

[0060] It should be noted that the diameter of the closed blade assembly 12 is the same as the diameter of the blade holder 11.

[0061] In this embodiment, the pen clip 212 is designed on one end of the pen body 211 near the first stepped hole 215; a second groove 214 is also designed on the first groove 213 near the pen clip 212.

[0062] In this embodiment, the pen clip 212 is also designed with a first protrusion 2121, and the pen body 211 is designed with a first square hole 219 and a second square hole 2110 that are adapted to the first protrusion 2121 at one end near the pen clip 212. The elastic limiting rod 33 is also designed with a second protrusion 331 that is adapted to the first square hole 219 and the second square hole 2110.

[0063] In this embodiment, the push rod 32 is installed in the first groove 213, and the elastic limiting rod 33 is designed on the end of the push rod 32 near the pen clip 212. The end of the push rod 32 near the pen clip 212 is also designed with a third groove 35 that matches the second groove 214. The first elastic member 34 is installed in the second groove 214 and the third groove 35. The end of the push rod 32 away from the thumb pressing part 31 is also machined with a third triangular hole 36. The end of the push rod 32 away from the thumb pressing part 31 is connected to the push sleeve 37.

[0064] In this embodiment, the push sleeve 37 is sequentially designed with a fifth stepped hole 371 and a sixth stepped hole 372 coaxial with itself. The inner diameter of the fifth stepped hole 371 is the same as the outer diameter of the end of the pen body 211 with the fourth stepped hole 218, and the inner diameter of the sixth stepped hole 372 is the same as the diameter of the blade 11. The push sleeve 37 is fitted onto the end of the pen body 211 with the fourth stepped hole 218. One end of the push sleeve 37 is conical, and the end of the push sleeve 37 away from the conical surface is designed with a third protrusion 373 and a fourth protrusion 374 that are adapted to the third triangular hole 36. The third protrusion 373 is designed with an inclined surface. The end of the push sleeve 37 away from the conical surface is connected to the end of the push rod 32 with the third triangular hole 36.

[0065] It should be noted that the connection between the push sleeve 37 and the push rod 32 is achieved by the third protrusion 373 being embedded in the third-shaped hole 36.

[0066] Understandably, the third protrusion 373 is designed with a bevel, the purpose of which is to facilitate the insertion of the third protrusion 373 into the third protrusion 373.

[0067] As a preferred implementation method, the working principle of the tumor tissue sampling pen is as follows:

[0068] Hold the pen body 211 with four fingers and place your thumb on the pressing part 2211. Press down, and the pen cap sleeve 2212 moves downward. The protruding tooth 2214 below the pen cap sleeve 2212 contacts the inclined surface on the plate 2233, pushing the rotating column 223 downward. When the plate 2233 on the rotating column 223 is completely pushed out from the guide rail formed by the two adjacent guide columns 2221 on the guide sleeve 222, the rotating column 223 is subjected to an upward force due to the compression of the second elastic element 111 below. When the inclined surface on the plate 2233 contacts the protruding tooth 2214, it rotates further.

[0069] When the pen cap 221 is released, the rotating column 223 moves further upward. After the plate 2233 contacts the stepped tooth 2223 on the guide sleeve 222, it rotates further and stops at the uppermost end of the stepped tooth 2223 near the fourth groove 2222.

[0070] For the tissue cutting assembly 1, when the pen cap 221 is pressed, the rotating column 223 and the connecting rod 23 move downward, pushing the blade bar 11, and the blade assembly 12 extends out from the sixth step hole 372 in the push sleeve 37, and the blade assembly 12 changes from the closed state to the open state.

[0071] Next, align the blade assembly 12 with the sampled tissue, insert the blade assembly 12 into the tissue, press the thumb pressing part 31 of the push rod assembly 3 with your thumb, and after the push rod assembly 3 is pressed, it pushes the push sleeve 37 downward. After the push sleeve 37 moves downward, the blade assembly 12 in the open state is converted into a closed state, thereby cutting the tissue and storing it in the closed blade assembly 12.

[0072] Meanwhile, as the push rod assembly 3 moves downward, the second protrusion 331 on the elastic limiting rod 33 moves from the first square hole 219 into the second square hole 2110, so that after the thumb is released, the push rod assembly 3 will not move upward under the action of the first elastic element 34.

[0073] Then move the tissue sampling pen onto the culture dish and press the pen clip 212, causing the first protrusion 2121 to squeeze the second protrusion 331 on the elastic limiting rod 33, causing it to move inward, causing the push rod assembly 3 to reset under the action of the first elastic element 34.

[0074] Then the blade assembly 12 changes from the closed state to the open state again, and the tissue block taken falls from the blade assembly 12 into the culture dish.

[0075] By repeatedly aligning the tissue sampling pen with the tissue, pressing the push rod assembly 3 to cut the tissue, and then moving it to the culture dish, pressing the pen clip 212 to allow the tissue to enter the culture dish, the tissue blocks can be cut in batches conveniently and quickly.

[0076] After use, press the pen cap 221 again. The protruding teeth 2214 below the pen cap 221 push the rotating column 223 downward. The rotating column 223 rotates further under the action of the spring force of the second elastic element 111. After releasing the pen cap 221, it returns to its original position.

[0077] Under the action of the spring force of the second elastic element 111, the blade assembly 12 moves upward and gradually enters the sixth step hole 372 inside the push sleeve 37, and then gradually changes from the open state to the closed state.

[0078] The above are merely preferred embodiments of the present invention and are not intended to limit the present invention. Various modifications and variations can be made to the present invention by those skilled in the art. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the scope of protection of the present invention.

Claims

1. A tumor tissue sampling pen, comprising: The utility model relates to a pen type tissue cutting device, including: Tissue cutting assembly, the tissue cutting assembly includes the sword pole and the blade group, the blade group sets up one end of the sword pole; Rotary assembly, the rotary assembly includes the pen body mechanism, the rotation mechanism and the connecting rod, the rotation mechanism and the connecting rod all set up in the pen body mechanism, the rotation mechanism still includes the pen cap, the guide sleeve and the rotation column, the pen cap is connected with the rotation column through the guide sleeve, the rotation column far from the guide sleeve one end with one end of the connecting rod abuts and connects; Push rod assembly, the push rod assembly includes the thumb press part, the push rod, the elastic limit piece, the first elastic piece and the push sleeve, the elastic limit piece sets up on the push rod near one end of the thumb press part, the first elastic piece and the push rod mutually abut, the push rod far from one end of the thumb press part with the push sleeve connects; The pen body mechanism includes the pen body, the pen clamp and sets up the first recess in the pen body axis direction, the pen body is sequentially provided with the first stepped hole, the second stepped hole, the third stepped hole and the fourth stepped hole with the pen body coaxial line, the pen clamp sets up on the pen body near one end of the first stepped hole, the first recess near one end of the pen clamp still is provided with the second recess; The guide sleeve is uniformly provided with a plurality of guide columns in the circumference, one end of the guide column is provided with a stepped tooth; The rotation column includes the first rotation column, the second rotation column and the sheet body, the sheet body is uniformly provided along the connecting stepped surface of the first rotation column and the second rotation column, one end of the sheet body is provided with the inclined surface that is adapted with the stepped tooth; One end of the pen clamp is also provided with the first convex, the pen body near one end of the pen clamp is provided with the first square hole and the second square hole that are adapted with the first convex, the elastic limit piece is also provided with the second convex that is adapted with the first square hole and the second square hole; The push rod is provided in the first recess, the elastic limit piece is provided on the push rod near one end of the pen clamp, one end of the push rod far from the thumb press part is also provided with the third square hole; One end of the push sleeve is a taper surface, the push sleeve far from one end of the taper surface is provided with the third convex and the fourth convex that are adapted with the third square hole, the third convex is provided with an inclined surface.

2. The tumor tissue sampling pen of claim 1, wherein, The pen cap also includes the press part, the pen cap sleeve, the sheet convex and the protruding tooth, the outer diameter of the pen cap sleeve is same with the diameter of the first stepped hole, the pen cap sleeve is provided in the first stepped hole, the protruding tooth is uniformly provided on the pen cap sleeve far from one end of the press part, the sheet convex is uniformly provided on the pen cap sleeve near one end of the protruding tooth.

3. The tumor tissue sampling pen of claim 1, wherein, The outer diameter of the guide sleeve is same with the diameter of the second stepped hole, the rotation column and the guide sleeve are all provided in the second stepped hole, the diameter of the connecting rod is same with the diameter of the third stepped hole, the connecting rod is provided in the third stepped hole, one end of the connecting rod is abutted with the end of the rotation column far from the guide sleeve, the end of the connecting rod far from the rotation column is threadedly connected with the end of the sword pole far from the blade group.

4. The tumor tissue sampling pen of claim 3, wherein, The diameter of the cutter bar is same as the diameter of the fourth stepped hole, the cutter bar is arranged in the fourth stepped hole; a second elastic member is further arranged on the cutter bar, one end of the second elastic member abuts against one end of the connecting rod connected with the cutter bar, and the other end of the second elastic member abuts against the stepped surface of the third stepped hole.

5. The tumor tissue sampling pen of claim 1, wherein, The push rod is further provided with a third groove matched with the second groove at one end close to the pen clamp, and the first elastic member is arranged in the second groove and the third groove.

6. The tumor tissue sampling pen of claim 5, wherein, The push sleeve is sequentially provided with a fifth stepped hole and a sixth stepped hole coaxial with the push sleeve; the inner diameter of the fifth stepped hole is same as the outer diameter of one end of the pen body provided with the fourth stepped hole, the inner diameter of the sixth stepped hole is same as the diameter of the cutter bar, and the push sleeve is sleeved on one end of the pen body provided with the fourth stepped hole; one end of the push sleeve away from the conical surface is connected with one end of the push rod provided with the third square hole.

7. The tumor tissue sampling pen of claim 2, wherein, The distance between two adjacent guide columns is same as the width of the sheet-shaped protrusion, and the inner wall of each guide column is provided with a fourth groove matched with the sheet-shaped protrusion.

8. The tumor tissue sampling pen of claim 6, wherein, The diameter of the first rotating column is same as the inner diameter of the pen cap sleeve, the diameter of the second rotating column is same as the diameter of the second stepped hole, and the width of the sheet-shaped body is same as the distance between two adjacent guide columns.

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