A zebrafish commercial feeding and breeding management system and a management method thereof

Abstract

The application discloses a zebrafish commercial feeding and breeding management system and a management method thereof, an exogenous parameter management module mainly comprises an environment parameter management module and a breeding parameter control module, and can ensure normal operation of equipment in a fish house and visually record equipment parameter indexes; a breeding and feeding part comprises a breeding module, a young fish breeding module, a adult fish breeding module, a special strain construction service module and a sperm freezing management module, and is used for recording a zebrafish feeding and breeding link process in detail. The application realizes effective management of a zebrafish commercial feeding and breeding process, each module can accurately analyze a zebrafish growth state in real time, and timely response can be made, the whole feeding and breeding process has high automation, process connection is smooth, and data traceability is good. The application meets the demand of zebrafish experimental breeding, breeding, selling process management.

Description

TECHNICAL FIELD

[0001] The application belongs to the technical field of experimental animal management, and particularly relates to a zebrafish commercial breeding management system and a management method thereof. BACKGROUND

[0002] Zebrafish is a small tropical freshwater fish originally from South Asia, and has a genetic homology of 87% with humans. Due to its easy feeding, strong reproductive capacity, fast development, transparent fertilized eggs and other characteristics, it has become a widely used vertebrate experimental animal in the world and is widely used in different fields such as disease model creation, gene function evaluation, drug screening, toxicity detection and environmental health risk assessment.

[0003] As an important model animal for researches in life science, health science and environmental science, the zebrafish strain commercial breeding and breeding industry chain is increasing, and the requirement for its management system is also increasing. At present, most of the zebrafish laboratories or commercial companies in China are through internal small databases or Excel, Word and other office software to organize and save fish strain data. In view of the complexity of zebrafish genetic information, the complexity of reproductive cycle and the time segment of breeding, the current management system is difficult to achieve the management goals of systematicness, comprehensiveness and information automation, and there is an urgent need for a zebrafish commercial breeding and breeding management system which can provide comprehensive information interaction with various zebrafish databases, automatic update of strain information in the system, convenient information input and query. SUMMARY

[0004] The purpose of the present application is to provide a management system and method for zebrafish commercial breeding and breeding, to improve the management efficiency and control ability of zebrafish in breeding, breeding and selling process, and to realize information management and data induction, so as to ensure the efficiency of zebrafish commercial breeding and sales. The main technical scheme of the present application is as follows:

[0005] A zebrafish commercial breeding management system, comprising a parameter control system, an environmental parameter management module, a breeding parameter management module, an information input module, an exogenous adult fish breeding system, a central breeding processing system, an adult fish / egg selling system, the exogenous adult fish breeding system, the central breeding processing system and the cloud database are in communication connection;

[0006] The parameter control system is used to send various set parameters to the system, receive information from the environmental parameter management module and the breeding parameter management module, and analyze and process the received feedback results. The ZIF EVE1 control system controls the system to complete the real-time monitoring function, ensures the normal operation of the equipment in the fish room and visualizes the recording and storage of equipment parameter indexes. When each environment exceeds the normal threshold, the ZIF EVE1 control system sends an early warning through the alarm system;

[0007] The environmental parameter management module is used for guaranteeing the breeding environment, and the module comprises a temperature sensing regulator, a pH value sensor, an O2 sensing and oxygenation device, a water quality monitoring regulator, and a ventilation barrier; the control of the exogenous adult fish breeding system and the central breeding processing system;

[0008] The breeding parameter control module is used for providing basic breeding conditions for zebrafish, and the module comprises a water purification and preparation device, a breeding water circulation system, and a fish food feeder.

[0009] The information input module is used for registering the new strain name, the strain source, inputting the strain characteristics and phenotype photos, and inputting the fish strain detailed information. After the information input module content is uploaded to the cloud database, the database management system takes the strain name as a record entry, and data is analyzed and classified according to each strain name. The newly registered zebrafish strain in the information input module is transferred to the exogenous adult fish breeding system or the central breeding processing system.

[0010] After the adult fish in the exogenous adult fish breeding system produces fry, the fertilized eggs are subjected to sterile treatment and then enter the central breeding processing system for breeding.

[0011] The central breeding processing system comprises five modules, i.e., breeding management, juvenile fish breeding, adult fish breeding, special strain construction, and sperm freezing management. Each record in the cloud database corresponds to only one zebrafish strain, and the data information of the same strain zebrafish among the modules is communicated through the central cloud database, and the modules can call each other.

[0012] Under the cloud database management, the central breeding processing system is also used for querying or manually updating the strain breeding state, and is also used for intelligently judging the time point at which each strain enters the breeding management, juvenile fish breeding and adult fish breeding modules and giving a prompt.

[0013] The central breeding processing system is also used for providing a "customer purchase demand information query" service for customers.

[0014] The application also provides a management method of the management system.

[0015] A zebrafish commercial breeding and breeding management method comprises exogenous parameter management and breeding management.

[0016] (1) the exogenous parameter management part

[0017] The exogenous parameter management part is completed by the environmental parameter management module, the breeding parameter management module and the parameter control system. The parameter control system is used for sending various set parameters to the system, receiving information from the environmental parameter management module and the breeding parameter management module, and analyzing and processing the received feedback results.

[0018] (a) The environmental parameter management module is used to protect the breeding environment. The exogenous adult fish breeding system and the central breeding processing system are controlled by two sets of environmental parameter management modules to avoid the invasion of exogenous pathogens and ensure low environmental risk.

[0019] The environmental parameter management module is controlled by the central computer parameter control system. The operating indicators of the environmental parameter management module are transmitted to the parameter control system in real time through the information transmission system. The real-time monitoring function is completed by the parameter control system to ensure the normal operation of the equipment in the fish room and the visual recording and storage of equipment parameter indicators. When the environment exceeds the normal threshold, the ZIF EVE1 control system will issue a warning through the alarm system to remind the experimenters to pay attention to the changes in environmental conditions in a timely manner.

[0020] (b) The breeding parameter control module is also completed under the command of the parameter control system. The breeding parameter control module provides the basic breeding conditions for zebrafish;

[0021] (2) Breeding management part

[0022] The breeding management part is composed of an information input module, an exogenous adult fish breeding system, a central breeding processing system, and an adult fish / egg selling system. The input and updated information of each part is integrated and processed by the cloud database. Based on data sharing, the newly input data is updated and improved to form an intelligent data management system.

[0023] (a) For the zebrafish strains introduced into the central breeding processing system from the exogenous adult fish breeding system, the staff is required to register the new strain name, strain source, input the strain characteristics, phenotype photos, and fish strain detailed information in the information input module. After uploading the information input module content to the cloud database, the database management system records the strain name as the entry, and analyzes and classifies the data based on the strain name.

[0024] (b) The newly registered zebrafish strains in the information input module will be transferred to the exogenous adult fish breeding system or the central breeding processing system. To avoid infection of exogenous pathogens, after the adult fish in the exogenous adult fish breeding system give birth to their offspring, the fertilized eggs need to be sterilized before entering the central breeding processing system for breeding. Due to the complexity of zebrafish genetic information and the characteristics of commercial sales, the central breeding processing system is divided into five modules: breeding management, juvenile fish breeding, adult fish breeding, special strain construction, and sperm freezing management. Each record in the cloud database corresponds to only one zebrafish strain. The data information of the same strain of zebrafish between modules can be communicated through the central cloud database, and the data between modules can be called;

[0025] (c) Under the management of the cloud database, the central breeding processing system queries or manually updates the breeding status of the strain;

[0026] After the staff completes a batch of passaging or tank arrangement, they need to manually enter information updates in the "Strain Breeding Status" administrator interface according to the prompts, and the entered information will be automatically uploaded to the cloud database related entries, integrated with the existing information of the strain, and automatically inherited the relevant information of the paternal and maternal lines.

[0027] (d) The central breeding processing system intelligently determines the time points when each strain enters the breeding management, juvenile fish breeding, and adult fish breeding modules and provides prompts under the management of the cloud database. First, the central breeding processor sets the relevant breeding information and common time nodes of zebrafish, automatically analyzes the appropriate passaging time of the relevant strain, the time when the embryos in the incubator need to be moved to the new juvenile fish breeding module, and the time when the juvenile fish breeding module needs to be moved to the new adult fish breeding module, and pops up an automatic prompt before the time node. When the breeding processor determines that a strain has grown and developed to maturity and is in good growth condition, and determines that the passaging or selling requirements are met, a "mating" interface will pop up. After the staff completes the mating steps, they click the "OK" button, and the processor automatically records the operation time point and uploads it to the cloud database.

[0028] The central breeding processing system conducts real-time statistics on the usage of the breeding tanks in the system to obtain idle tank information. When the processor determines that a new juvenile fish breeding module or a new adult fish breeding module is needed, it specifies some tank positions and defines them as new juvenile fish breeding tanks or new adult fish breeding tanks. After the staff moves them according to the specified positions and clicks the "OK" button, the new tank positions automatically inherit all the information under the strain entry and upload it to the cloud database after software analysis and processing for subsequent queries.

[0029] (e) The central breeding processing system provides "customer purchase demand information query" services for customers. Customers who have needs can enter the name or keywords of the zebrafish strain they need to query on the website. The breeding processing system retrieves the cloud database and analyzes and integrates the relevant information of the strain, including whether there are adult fish / eggs of the strain, the full name of the strain, the strain status, the gene name, the appearance phenotype photo of the strain, the fluorescence photo of the transgenic fish, the human homologous gene, the human homologous gene associated disease, the corresponding price, and the personal demand note box. After clicking the payment interface to complete the subsequent payment and address input steps, customers fill in special needs and note information in the "personal demand note" entry.

[0030] The present application has the following beneficial effects relative to the prior art: the environmental parameter management module and the breeding parameter control module are provided, and the two modules can cooperate to complete the environmental monitoring and feeding state monitoring of the breeding system, and the automation degree is high, which greatly saves manpower, material resources and time cost. In the breeding management system, the breeding module, the juvenile fish breeding module, the adult fish breeding module, the special strain construction service module and the sperm freezing management module are provided, and the remote information database is provided, the information mastered can be updated to the server in real time, and the breeding process various information has traceability. It can serve the whole zebrafish process and life cycle supervision and control. Adapt to modern commercial breeding environment, improve the efficiency and effect of fish room commercial management, realize all-round, efficient and informationized quality control management. BRIEF DESCRIPTION OF DRAWINGS

[0031] In order to more clearly illustrate the technical solutions of the embodiments of the present application, the following will briefly introduce the drawings needed to be used in the description of the embodiments of the present application. Obviously, the following description of the descriptive drawings of the present patent is provided for reference.

[0032] Figure 1 It is a schematic diagram of the principle structure of the present application;

[0033] Figure 2 It is a data processing flow chart of the "new strain information input" function of the management system of the present application;

[0034] Figure 3 It is a data processing flow chart of the "strain breeding state" function of the management system of the present application;

[0035] Figure 4 It is a data processing flow chart of the "breeding generation reminding" function of the management system of the present application;

[0036] Figure 5 It is a data processing flow chart of the "purchase information query" function of the management system of the present application. DETAILED DESCRIPTION

[0037] The embodiments of the present application will be further clearly and completely described below in combination with examples. The examples described herein are only used to explain the present application, and are not used to limit all embodiments.

[0038] As shown in Figure 1 A zebrafish commercial feeding and breeding management system, including a parameter regulation system ZIF EVE1, an environmental parameter management module 001, a breeding parameter management module 002, an information input module 101, an exogenous adult fish breeding system 102, a central breeding processing system 103, an adult fish / egg selling system 104, the exogenous adult fish breeding system 102, the central breeding processing system 103 and the cloud database are in communication connection;

[0039] Parameter control system ZIF EVE1 is used to send various set parameters to the system, receive information from environmental parameter management module 001 and breeding parameter management module 002, and analyze and process the received feedback results. The ZIF EVE1 control system completes the real-time monitoring function, ensures the normal operation of the equipment in the fish room, and visualizes the record storage device parameter indicators. When the environment exceeds the normal threshold, the ZIF EVE1 control system sends an early warning through the alarm system.

[0040] The environmental parameter management module 001 is used to protect the breeding environment, which includes temperature sensing regulator, pH sensor, 02 sensing and oxygenation device, water quality monitoring regulator, and ventilation barrier; control the exogenous fish breeding system 102 and the central breeding processing system 103.

[0041] The breeding parameter control module 002 is used to provide basic breeding conditions for zebrafish, including water purification and preparation device, breeding water circulation system, and fish food feeder.

[0042] The information input module 101 records the new strain name, strain source, strain characteristics, and phenotype photos in detail, and uploads the detailed information of the fish strain to the cloud database. The database management system records the strain name as an entry, and analyzes and classifies the data based on the strain name. The newly registered zebrafish strain in the information input module 101 is transferred to the exogenous fish breeding system 102 or the central breeding processing system 103.

[0043] After the adult fish in the exogenous fish breeding system 102 produces offspring, the fertilized eggs are subjected to sterile treatment and then enter the central breeding processing system 103 for breeding.

[0044] The central breeding processing system 103 includes breeding management, juvenile fish breeding, adult fish breeding, special strain construction, and sperm freezing management. Each record in the cloud database corresponds to only one zebrafish strain, and the data information of the same strain of zebrafish among the modules is communicated through the central cloud database, and the modules can call each other.

[0045] Under the management of the cloud database, the central breeding processing system 103 is also used to query or manually update the breeding status of the strain, and to intelligently determine the time point when each strain enters the breeding management, juvenile fish breeding, and adult fish breeding modules and provide prompts.

[0046] The central breeding processing system 103 is also used to provide "customer purchase demand information query" service for customers.

[0047] Based on the above management system, the embodiment also provides a zebrafish commercial breeding and management method, which includes exogenous parameter management and breeding management.

[0048] I. Exogenous parameter management part

[0049] The exogenous parameter management part is completed by the environmental parameter management module 001, the breeding parameter management module 002 and the parameter control system ZIF EVE1. The parameter control system ZIF EVE1 is used to send various set parameter indicators to the equipment, receive information from the two exogenous parameter modules, and analyze and process the received feedback results.

[0050] (a) The environmental parameter management module 001 is mainly used to protect the breeding environment. This module includes temperature sensing regulator, pH sensor, 02 sensing and oxygenation device, water quality monitoring regulator, ventilation barrier, exogenous fish breeding system 102 and central breeding processing system 103, which are respectively controlled by two sets of environmental parameter management modules to avoid exogenous pathogen invasion and ensure low risk of the environment. Each device is controlled by the central computer parameter control system ZIF EVE1 in the equipment room. The equipment operation indicators are transmitted to the parameter control system ZIF EVE1 in real time through the information transmission system, and the real-time monitoring function is completed by the parameter control system ZIF EVE1 control system to ensure the normal operation of the equipment in the fish room and the visual record storage of the equipment parameter indicators. When each environment exceeds the normal threshold, the ZIF EVE1 control system will issue a warning through the alarm system to remind the experimenters to pay attention to the change of environmental conditions in time.

[0051] (b) The breeding parameter control module 002 is also completed under the command of the parameter control system ZIF EVE1. The breeding parameter control module 002 provides the basic breeding conditions for zebrafish, including water purification and preparation device, breeding water circulation system and fish food feeder. The parameter control system ZIF EVE1 is used to send various set parameter indicators to the equipment, receive information from the two exogenous parameter modules, and analyze and process the received feedback results.

[0052] II. Breeding management part

[0053] The breeding management part is composed of information input module 101, exogenous fish breeding system 102, central breeding processing system 103 and fish / egg selling system 104. The input and updated information of each part is integrated and processed by the cloud database. On the basis of data sharing, the newly input data is updated and improved to form an intelligent data management system.

[0054] (a) In this embodiment, the zebrafish strain constructed in the exogenous fish breeding system 102 is introduced into the central breeding processing system 103, such as Figure 2As shown, the staff is required to register the new strain name, strain source (purchase origin, builder), enter the strain characteristics (genotype, gene mutation site), phenotype photos (fish and embryo stereoscope, transgenic fish fluorescence photos), and fish strain detailed information (purchase price, quantity, gender, health status, spawning situation) in the information input module 101. After the content of the information input module 101 is uploaded to the cloud database, the database management system takes the strain name as the record entry, and the data is analyzed and classified based on each strain name.

[0055] (b) The newly registered zebrafish strain in the information input module 101 will be transferred to the exogenous adult fish breeding system 102 or the central breeding processing system 103. To avoid infection of exogenous pathogens, after the adult fish in the exogenous adult fish breeding system 102 gives birth to offspring, the fertilized eggs need to be subjected to sterile treatment before entering the central breeding processing system 103 for breeding. Due to the complexity of zebrafish genetic information and the characteristics of commercial sale, the central breeding processing system 103 is divided into five modules: breeding management, juvenile fish breeding, adult fish breeding, special strain construction, and sperm freezing management. Each record in the cloud database corresponds to only one zebrafish strain, and the data information of the same strain zebrafish between modules can be communicated through the central cloud database, and the data can be called between modules to avoid repeated information input.

[0056] (c) Under the management of the cloud database, the central breeding processing system 103 can query or manually update the strain breeding status in time. As shown, Figure 3 If the staff needs to query the status of the zebrafish strain in the system, they can input the name or key word of the desired query strain in the "strain breeding status" interface, the system will retrieve the relevant information from the cloud database, analyze and integrate the data, and automatically output the breeding generation, tank position, number, status, age, gender, and breeding times of the strain. By clicking on the detailed information, the historical transaction information can be further displayed. After the staff completes a batch of transmission or tank arrangement, they need to manually input the information update (tank change, breeding date and status, and new fry birth date) in the "strain breeding status" administrator interface according to the prompts, and the input information will be automatically uploaded to the relevant entries in the cloud database, integrated with the existing information of the strain, automatically inherited the relevant information of the paternal and maternal strains, reducing the workload and avoiding repeated information input, and ensuring data standardization.

[0057] (d) Under the management of the cloud database, the central breeding processing system 103 intelligently determines the time point when each strain enters the breeding management, juvenile fish breeding, and adult fish breeding modules and provides prompts. As shown, Figure 4As shown, first set the zebrafish related breeding information and common time nodes in the central breeding processor, according to the information stored in the cloud data, automatically analyze the suitable generation time of the related strain, the time when the embryos in the incubator need to be moved into the new juvenile fish breeding module, and the time when the juvenile fish breeding module needs to be moved into the new adult fish breeding module, and pop up an automatic prompt before the time node. When the breeding processor determines that a strain has grown and developed to maturity and has a good growth state, the "mating" interface will pop up when the processor determines that the generation demand or the demand for sale is met. After the staff completes the mating steps, click the "OK" button, and the processor automatically records the operation time point and uploads it to the cloud database.

[0058] The breeding processor performs real-time statistics on the use of the breeding tank in the system to obtain idle slot information. When the processor determines that "new juvenile fish breeding module needs to be moved in" or "new adult fish breeding module needs to be moved in", it will specify part of the slots and define them as new juvenile fish breeding tanks or new adult fish breeding tanks. After the staff moves in according to the specified position and clicks the "OK" button, the new slot automatically inherits all information under the strain item and uploads it into the cloud database after software analysis and processing for subsequent query.

[0059] (e) The central breeding processing system 103 provides "customer purchase demand information query" service for customers, such as Figure 5 As shown, customers with needs enter the name or key words of the zebrafish strain they need to query on the website, and the breeding processing system 103 retrieves the cloud database and analyzes and integrates the related information of the strain, including whether the strain is provided (adult fish / eggs), strain full name, strain status, gene name (NCBI ID / MGI ID / Ensembl ID), gene mutation strain appearance phenotype photo or transgenic fish fluorescence photo, human homologous gene, human homologous gene associated disease, corresponding price and personal demand note box. Click the payment interface to complete the subsequent payment and address input steps. Customers can fill in special needs and note information in the "personal demand note" item to help staff analyze customer needs and provide more market-oriented zebrafish product services.

Claims

1. A method for managing a zebrafish commercial breeding management system, which adopts a zebrafish commercial breeding management system, comprising a parameter control system (ZIF EVE1), an environmental parameter management module (001), a breeding parameter management module (002), an information input module (101), an exogenous adult fish breeding system (102), a central breeding processing system (103), and an adult fish / egg selling system (104), wherein the exogenous adult fish breeding system (102) and the central breeding processing system (103) are in communication connection with a cloud database; the parameter control system (ZIF EVE1) is used to send various set parameters to the system, receive information from the environmental parameter management module (001) and the breeding parameter management module (002), and analyze and process the received feedback results; the parameter control system (ZIF EVE1) controls the system to complete real-time monitoring function, ensures normal operation of the equipment in the fish room and visual recording and storage of equipment parameter indexes, and sends early warning through an alarm system when each item of environment exceeds the normal threshold; the environmental parameter management module (001) is used to ensure the breeding environment, which comprises a temperature sensor regulator, a pH sensor, an O2 sensor and an oxygenation device, a water quality monitoring regulator, and a ventilation barrier; the exogenous adult fish breeding system (102) and the central breeding processing system (103) are controlled; the breeding parameter management module (002) is used to provide basic breeding conditions for zebrafish, including a water purification device, a breeding water circulation system, and a fish food feeder; the information input module (101) records the new strain name, strain source, strain characteristics, and phenotype photos in detail, and the fish strain detailed information; after the information input module (101) content is uploaded to the cloud database, the database management system takes the strain name as a record item, and analyzes and classifies data based on each strain name; the newly recorded zebrafish strain in the information input module (101) is transferred to the exogenous adult fish breeding system (102) or the central breeding processing system (103); after the adult fish in the exogenous adult fish breeding system (102) produces fry, the fertilized eggs are subjected to sterile treatment and then enter the central breeding processing system (103) for breeding; the central breeding processing system (103) comprises five modules, i.e., breeding management, juvenile fish breeding, adult fish breeding, special strain construction, and sperm freezing management; each record in the cloud database corresponds to only one zebrafish strain, and the data information of the same strain zebrafish among the modules is communicated through the central cloud database, and each module calls each other; under the management of the cloud database, the central breeding processing system (103) is also used to query or manually update the breeding state of the strain, intelligently judge the time point when each strain enters the breeding management, juvenile fish breeding, and adult fish breeding modules, and give a prompt; the central breeding processing system (103) is also used to provide a "customer purchase demand information query" service for customers; the method comprises exogenous parameter management and breeding management; characterized in that (I) exogenous parameter management part ​ The exogenous parameter management part is completed by the environmental parameter management module (001), the breeding parameter management module (002) and the parameter control system (ZIF EVE1); the parameter control system (ZIF EVE1) is used to send various set parameter indexes to the system, receive information from the environmental parameter management module (001) and the breeding parameter management module (002), and analyze and process the received feedback results; (a) The environmental parameter management module (001) is used to protect the breeding environment, and the exogenous adult fish breeding system (102) and the central breeding processing system (103) are respectively controlled by two sets of environmental parameter management modules to avoid exogenous pathogen invasion and ensure low environmental risk; The environmental parameter management module (001) is controlled by the central device computer parameter control system (ZIF EVE1), and the running index of the environmental parameter management module (001) is transmitted to the parameter control system (ZIF EVE1) in real time through the information transmission system, and the real-time monitoring function is completed by the parameter control system (ZIF EVE1) control system, which ensures the normal operation of the equipment in the fish room and visual record storage equipment parameter index, when each environment exceeds the normal threshold, ZIF EVE1 control system will send an early warning through the alarm system, reminding the experimenters to pay attention to the change of environmental conditions in time; (b) The breeding parameter management module (002) is also completed under the command of the parameter control system (ZIF EVE1); the breeding parameter management module (002) provides the basic breeding conditions of zebrafish; (II) Breeding management part The breeding management part is composed of information input module (101), exogenous adult fish breeding system (102), central breeding processing system (103) and adult fish / egg selling system (104), and the input and updated information of each part is integrated and processed by cloud database, and on the basis of data sharing, the newly input data is updated and improved to form an intelligent data management system; (a) For the zebrafish strain constructed in the central breeding processing system (103) introduced in the exogenous adult fish breeding system (102), the staff is required to register the new strain name, strain source in the information input module (101) in detail, input the characteristics, phenotype photos and fish strain detailed information of the strain, and after the information input module (101) content is uploaded to the cloud database, the database management system takes the strain name as the record item, and the data is analyzed and classified according to the strain name. (b) The zebrafish strain newly registered by the information input module (101) will be transferred to the exogenous adult fish breeding system (102) or the central breeding processing system (103); in order to avoid infection of exogenous pathogens, after the adult fish in the exogenous adult fish breeding system (102) gives birth to offspring, the fertilized eggs need to be subjected to sterile treatment before entering the central breeding processing system (103) for breeding; in view of the complexity of zebrafish genetic information and the characteristics of commercial sale, the central breeding processing system (103) is divided into five modules of breeding management, juvenile fish breeding, adult fish breeding, special strain construction and sperm freezing management; each record in the cloud database corresponds to only one zebrafish strain, and the data information of the same strain zebrafish between the modules is communicated through the central cloud database, and the data between the modules is called each other; (c) Under the management of the cloud database, the central breeding processing system (103) queries or manually updates the strain breeding state; After the staff completes a batch of subcultures or breeding tank arrangement, they need to manually input information update in the "strain breeding state" administrator interface according to the prompt, and the input information will be automatically uploaded to the relevant entries under the cloud database, integrated with the existing information of the strain, and automatically inherited the relevant information of the paternal and maternal lines; (d) Under the management of the cloud database, the central breeding processing system (103) intelligently judges the time points when each strain enters the breeding management, juvenile fish breeding and adult fish breeding modules and prompts; first, the central breeding processor sets the relevant breeding information and common time nodes of zebrafish, automatically analyzes the appropriate subculture time of the relevant strain, the time when the embryos in the incubator need to be moved to the new juvenile fish breeding module, and the time when the juvenile fish breeding module needs to be moved to the new adult fish breeding module, and pops up an automatic prompt before the time node; when the breeding processor judges that a strain has grown and developed to maturity and has a good growth state, a "mating" interface will pop up when the processor judges that the subculture demand or the sale demand is met, the staff completes the mating steps and clicks the "confirm" button, and the processor automatically records the operation time point and uploads it to the cloud database.

2. The management method of the zebrafish commercial breeding and propagation management system according to claim 1, characterized in that, The central breeding processing system (103) performs real-time statistics on the use of breeding tanks in the system to obtain idle tank information, and when the processor judges that "new juvenile fish breeding module is needed" or "new adult fish breeding module is needed", it specifies part of the tank positions and defines them as new juvenile fish breeding tanks or new adult fish breeding tanks, and after the staff moves them according to the specified positions and clicks the "confirm" button, the new tank positions automatically inherit all the information under the strain entry and upload them into the cloud database after software analysis and processing, for subsequent inquiry.

3. The management method of the zebrafish commercial breeding and propagation management system according to claim 1, characterized in that, The central breeding processing system (103) provides a "customer purchase demand information query" service for customers. Customers with demand input the name or key word of the desired zebrafish strain on the website. The breeding processing system (103) calls the cloud database and analyzes and integrates the information related to the strain, including whether the strain provides adult fish / eggs, the full name of the strain, the state of the strain, the gene name, the appearance phenotype photo of the mutant strain, the fluorescence photo of the transgenic fish, the human homologous gene, the human homologous gene associated disease, the corresponding price, and the personal demand note box. After clicking the payment interface, the customer completes the subsequent payment and address input step. The customer fills in the special demand and note information in the "personal demand note" item.

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