Reagent test card and its sample loading assembly

Abstract

This application relates to a reagent test card and its sample loading assembly. The sample loading assembly of the reagent test card includes a sample loading structure. The sample loading structure has a first end and a second end opposite to each other. The first end is used to connect to or abut against the detection part of the reagent test card. The sample loading structure forms a hollow channel extending from the first end to the second end. The inner wall material of the hollow channel is hydrophilically modified and the inner wall is smooth. And / or, the sample loading structure has a slit extending from the first end to the second end. The wall material of the slit is hydrophilically modified and the wall is smooth. On the one hand, the sample solution flows more uniformly and smoothly inside the hollow channel of the sample loading structure, and direct sample loading can be achieved while maintaining the original structure of the detection part. The sample loading operation is more convenient and reliable, and can realize the diversification of application scenarios and user groups. On the other hand, it can achieve uniform and residue-free sample loading, and the detection sensitivity and detection accuracy of the detection part are guaranteed.

Description

Technical Field

[0001] This application relates to the field of medical device technology, and in particular to a reagent test card and its sample loading assembly. Background Technology

[0002] In vitro diagnostic reagents primarily utilize biotechnology and are used in conjunction with in vitro diagnostic medical devices. They can be used alone or in combination with other equipment, instruments, and hardware, playing a crucial role in early disease assessment and prediction, disease prevention, diagnosis, and treatment monitoring. The samples tested are mainly different human bodily fluids, including serum, plasma, whole blood, urine, and saliva. Different types of products need to be designed to meet the specific needs of different applications. Immunodiagnostics constitutes the largest segment of the in vitro diagnostics market, with immunochromatography playing a vital role in product applications. Immunochromatography is characterized by its ease of operation, high practicality, and wide range of applications. It allows for the design of customized products to meet the specific needs of various applications, such as different departments in hospitals, health service centers, disaster medical rescue sites, food safety monitoring sites, customs quarantine, rapid screening for prohibited drugs, bioterrorism, forensic testing, and home use, ensuring the smooth operation of these various tasks.

[0003] For these product designs, the adaptability of the sampling and dispensing module is particularly crucial. The traditional main methods are direct dispensing with a pipette or using disposable sampling accessories that come with the product, such as blood collection tubes, droppers, pipettes, lancets, etc. Different dispensing methods are adopted depending on the applicable scenario and sample type. For example, quantitative detection products have high requirements for sample volume accuracy; after sampling, accessories that can quantitatively dispense liquid are used to draw a certain volume of sample to complete the dispensing. Or some qualitative or semi-quantitative projects do not have high requirements for sample volume accuracy, and reagent strips are directly inserted into the sample in the receiving container according to the instructions to complete the sample loading and detection.

[0004] The sampling and loading modules described above mainly fall into two categories, each with its own drawbacks: 1. Products equipped with sampling accessories, such as droppers, which makes operation cumbersome for users. The accuracy of reagent test results may be affected by user habits, and some users may resist "contact," leading to a poor experience. 2. Insertion-based loading: The sample pad of the reagent strip or the absorbent stick attached to the sample pad is directly inserted into the sample container for loading. The sample is guided to the labeling pad by capillary force through the sample pad or absorbent stick, allowing the analyte in the sample to bind with the labeled antibody on the labeling pad. Finally, the conjugate is chromatographically reacted on the nitrocellulose membrane along with the sample, generating a corresponding detection signal, from which the concentration of the analyte in the sample can be calculated. However, this detection method is affected by gravity during the low-to-high-layer chromatography process, and the release effect and uniformity of the analyte are also limited by the material and size of the absorbent stick. These factors may ultimately lead to problems such as low detection sensitivity and insufficient precision. At the same time, the limitation of the absorbent stick in controlling the sample volume greatly restricts its application in many project scenarios. Summary of the Invention

[0005] Therefore, it is necessary to overcome the shortcomings of the existing technology and provide a reagent test card and its sample loading component that is easy to use, can meet the requirements of sample loading uniformity and homogeneity, ensure detection sensitivity, and ensure detection precision.

[0006] The technical solution is as follows: a sample loading component for a reagent test card, the sample loading component for the reagent test card comprising:

[0007] The sample loading structure has a first end and a second end opposite to each other, the first end being used to connect to or abut against the detection part of the reagent detection card;

[0008] The sample loading structure has a hollow channel extending from the first end to the second end, and the inner wall material of the hollow channel is hydrophilically modified and has a smooth inner wall; and / or, the sample loading structure has a slit extending from the first end to the second end, and the wall material of the slit is hydrophilically modified and has a smooth wall.

[0009] In one embodiment, the aperture of the hollow channel or the size of the gap is 0.1mm-2mm; the length of the hollow channel or the length of the gap is 0.5cm-4cm.

[0010] In one embodiment, the sample loading assembly of the reagent test card further includes a first mounting shell; the sample loading structure portion passes through the interior of the first mounting shell, and the second end extends to the exterior of the first mounting shell.

[0011] In one embodiment, the central axis of the sample-mounting structure is set at an angle to the bottom surface of the first mounting shell, and the distance between the second end and the bottom surface is greater than the distance between the first end and the bottom surface.

[0012] In one embodiment, the angle between the central axis of the sample-mounting structure and the bottom surface of the first mounting shell is defined as α, where α is between 1° and 90°.

[0013] In one embodiment, at least one support protrusion is provided on the inner wall of the first mounting shell. The support protrusion abuts against the bottom surface of the sample loading structure. The distance from the part of the sample loading structure that abuts against the support protrusion to the bottom surface is a first distance. The distance from the part of the sample loading structure that abuts against the detection part to the bottom surface is a second distance. The first distance is greater than the second distance.

[0014] In one embodiment, the first end of the sample loading structure is provided with a beveled surface that is angled to its central axis, and the beveled surface is connected to or abuts against the detection part.

[0015] In one embodiment, a first positioning component is provided on the inner wall of the first mounting shell, the first positioning component being used to lock and position the sample structure.

[0016] In one embodiment, the sample loading structure includes at least two drainage elements arranged in a row, the outer wall of the drainage elements being hydrophilically modified, and adjacent drainage elements being spaced apart to form the gap; or, the sample loading structure includes at least one drainage element, and the gap is formed on the outer wall of the drainage element.

[0017] In one embodiment, the sample loading structure has at least two hollow channels arranged in a row; or, the sample loading structure has a capillary or at least two capillary tubes arranged in a row, wherein the capillary tube has the hollow channel.

[0018] A reagent test card, the reagent test card includes a sample loading component and a detection unit, wherein a first end is connected to or abuts against the detection unit.

[0019] In one embodiment, the reagent test card further includes a second mounting shell connected to the first mounting shell, and the detection unit is mounted on the second mounting shell.

[0020] In one embodiment, a second positioning component is provided on the inner wall of the second mounting housing, the second positioning component being used to lock and position the detection part.

[0021] The aforementioned reagent test card and its sample loading assembly, on the one hand, allow for more uniform and smoother flow of the sample solution within the hollow channels and / or gaps of the sample loading structure, enabling direct sample loading while maintaining the original structure of the detection unit. This makes the sample loading operation more convenient and reliable, and can accommodate diverse application scenarios and user groups. On the other hand, it enables residue-free sample loading, ensuring the detection sensitivity and accuracy of the detection unit. Attached Figure Description

[0022] The accompanying drawings, which form part of this application, are used to provide a further understanding of this application. The illustrative embodiments of this application and their descriptions are used to explain this application and do not constitute an undue limitation of this application.

[0023] To more clearly illustrate the technical solutions in the embodiments of this application, the accompanying drawings used in the description of the embodiments will be briefly introduced below. Obviously, the accompanying drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0024] Figure 1 This is an exploded view of the reagent test card according to an embodiment of the present invention;

[0025] Figure 2 for Figure 1 A magnified structural diagram at point A;

[0026] Figure 3 This is a schematic diagram of the sample loading structure according to an embodiment of the present invention.

[0027] Figure 4 This is a schematic diagram of the sample loading assembly of a reagent test card according to an embodiment of the present invention, after one of the first split shells is hidden.

[0028] Figure 5 This is a schematic diagram of the sample loading assembly of the reagent test card according to an embodiment of the present invention, after the other first split shell is hidden.

[0029] 10. Sample loading structure; 11. First end; 111. Beveled surface; 12. Second end; 13. Hollow channel; 14. First mounting shell; 141. First split shell; 142. Bayonet; 143. Support protrusion; 144. First positioning component; 1441. First holding member; 1442. Second holding member; 15. Second mounting shell; 151. Second split shell; 20. Detection unit; 30. Protective shell; 31. Protective cover. Detailed Implementation

[0030] To make the above-mentioned objectives, features, and advantages of this application more apparent and understandable, the specific embodiments of this application are described in detail below with reference to the accompanying drawings. Many specific details are set forth in the following description to provide a thorough understanding of this application. However, this application can be implemented in many other ways different from those described herein, and those skilled in the art can make similar modifications without departing from the spirit of this application. Therefore, this application is not limited to the specific embodiments disclosed below.

[0031] As described in the background section, existing sample loading methods, which involve directly inserting the sample pad of the test strip or an absorbent rod mounted on the sample pad into the sample container for sample loading, suffer from low detection sensitivity and insufficient precision. The inventors have discovered that this problem arises because adding an absorbent rod to the lower end of the test strip for flow guidance, in this vertical loading method, is affected by both gravity and the material of the absorbent rod, leading to reduced performance. Specifically, during the vertical loading process through the absorbent rod, due to gravity and the complex composition of different sample types, the sample undergoes upward chromatography. The difference in absorbency between the lower and upper ends during this process results in uneven chromatography. Furthermore, the complex composition of different sample types, along with the material, pore size, and density of the absorbent rod, causes some components to be adsorbed and remain within the absorbent rod, resulting in insufficient measurement accuracy and reduced sensitivity. In addition, if traditional absorbent rod technology is used for flow guidance, the structure of the test strip needs to be adjusted according to the size of the absorbent rod, which significantly affects the performance of the test strip.

[0032] For the reasons mentioned above, the present invention provides a reagent test card and its sample loading component, which is easy to use, can ensure the uniformity of sample loading, and can guarantee the detection sensitivity and detection precision.

[0033] See Figures 1 to 5 , Figure 1 An exploded view of the reagent test card according to an embodiment of the present invention is shown. Figure 2 It shows Figure 1 Enlarged structural diagram at point A Figure 3 This diagram shows a schematic view of the sample loading structure 10 according to an embodiment of the present invention. Figure 4 This diagram shows a schematic view of the sample loading assembly of a reagent test card according to an embodiment of the present invention, with one of the first split shells 141 concealed. Figure 5This diagram illustrates a schematic view of the sample loading assembly of a reagent test card according to an embodiment of the present invention, with another first split shell 141 concealed. An embodiment of this application provides a sample loading assembly for a reagent test card, comprising a sample loading structure 10. The sample loading structure 10 has a first end 11 and a second end 12 facing each other, the first end 11 being used to connect to or abut against the detection section 20 of the reagent test card.

[0034] The sample loading structure 10 has a hollow channel 13 extending from the first end 11 to the second end 12. The inner wall material of the hollow channel 13 is hydrophilically modified and has a smooth inner wall. Thus, during operation, when the sample loading structure 10, specifically the second end 12, is inserted into a sample container containing the sample solution, the hydrophilically modified inner wall of the hollow channel 13 allows the sample solution to be rapidly drawn into the hollow channel 13 under capillary action and supplied to the detection unit 20. Once in the detection unit 20, the sample solution can be analyzed and detected. Simultaneously, due to the smooth inner wall of the hollow channel 13, the sample solution is loaded without residue during its passage through the hollow channel 13.

[0035] Alternatively, the sample loading structure 10 may have a slit extending from the first end to the second end. The wall material of the slit may be hydrophilically modified and have a smooth surface. In this way, during operation, when the sample loading structure 10, specifically the second end 12, is inserted into a sample container containing the sample solution, the slit allows the sample solution to be rapidly drawn into the slit under capillary force and supplied to the detection unit 20. Once in the detection unit 20, the sample solution can be analyzed. Simultaneously, due to the smooth wall of the slit, the sample solution is loaded without residue during its passage through the slit.

[0036] Alternatively, the sample loading structure 10 may have a hollow channel 13 extending from the first end 11 to the second end 12. The inner wall material of the hollow channel 13 is hydrophilically modified and has a smooth inner wall. Furthermore, the sample loading structure 10 also has a slit extending from the first end to the second end. The slit's wall material is hydrophilically modified and has a smooth wall. Thus, during operation, when the sample loading structure 10, specifically the second end 12, is inserted into a sample container containing the sample solution, on the one hand, capillary force allows the sample solution to be rapidly drawn into the hollow channel 13 and supplied to the detection unit 20. On the other hand, the sample solution is also rapidly drawn into the slit and supplied to the detection unit 20 through the slit. This achieves better sample loading and higher loading efficiency. Simultaneously, due to the smooth inner wall of the hollow channel 13 and the smooth wall of the slit, the sample solution can be loaded without residue during its passage through the hollow channel 13 and the slit.

[0037] It should be noted that hydrophilic modification refers to improving the hydrophilicity of different materials through specific methods. Common methods include: chemical modification of surface structures, grafting, coupling to form hydrophilic functional groups; adsorption and fixation of hydrophilic modification agents; and blending modification. For example, when the sample loading structure is made of a non-hydrophilic material, such as fluorinated ethylene polypropylene, the hollow channel has a high surface charge and is highly hydrophobic. Hydrophilic modification can be achieved by coating the inner wall of the hollow channel with a hydrophilic substance. Coating the hollow channel with a hydrophilic substance can enhance its hydrophilicity and facilitate sample loading. Specific hydrophilic substances include, but are not limited to, polyethylene glycol, polyvinylpyrrolidone, low molecular weight polyvinyl alcohol crosslinked with sodium polyacrylate, crosslinked polyvinyl alcohol or composed thereof, cellulose derivatives, collagen, crosslinked chitosan, etc.

[0038] The sample loading component of the aforementioned reagent test card, on the one hand, allows for more uniform and smoother flow of the sample solution within the hollow channel 13 and / or gaps of the sample loading structure 10, enabling direct sample loading while maintaining the original structure of the detection unit 20. This makes the sample loading operation more convenient and reliable, and can accommodate diverse application scenarios and user groups. On the other hand, it enables residue-free sample loading, ensuring the detection sensitivity and accuracy of the detection unit 20.

[0039] Please see Figure 1 , Figures 3 to 5 In one embodiment, the length of the hollow channel 13 is including, but not limited to, 0.5cm-4cm, specifically, for example, 0.5cm, 1cm, 2cm, 3cm, and 4cm. Furthermore, the length of the hollow channel 13 can be flexibly adjusted to a value outside the 0.5cm-4cm range according to actual needs.

[0040] In addition, the aperture of the hollow channel 13 is not limited to 0.1mm-2mm, and can be flexibly adjusted to a value other than 0.1mm-2mm according to actual needs.

[0041] When the pore size of the hollow channel 13 is set to 0.1mm-2mm, the capillary force under this pore size is obvious, and the inner wall of the hollow channel 13 is hydrophilic, so the hollow channel 13 has a good sample adsorption force and can achieve continuous sample loading.

[0042] In a specific embodiment, when the aperture of the hollow channel 13 is set to 0.1mm-2mm and the length of the hollow channel is set to 0.5cm-4cm, not only can continuous sample loading be achieved, but also quantitative sample loading can be achieved.

[0043] Please see Figure 1 , Figures 3 to 5In another embodiment, the length of the gap is including, but not limited to, 0.5cm-4cm, specifically, for example, 0.5cm, 1cm, 2cm, 3cm, and 4cm. Furthermore, the length of the gap can be flexibly adjusted to a value outside the 0.5cm-4cm range according to actual needs.

[0044] Furthermore, the size of the gap can be, but is not limited to, 0.1mm-2mm, and can be flexibly adjusted to values ​​outside of 0.1mm-2mm according to actual needs. It is worth noting that the gap size here refers to the maximum distance between adjacent structures forming the gap.

[0045] In one specific embodiment, when the size of the slit is set to 0.1mm-2mm and the length is set to 0.5cm-4cm, it has good adsorption force and can achieve continuous sample loading.

[0046] Please see Figure 1 , Figures 3 to 5 In one embodiment, the sample loading assembly of the reagent test card further includes a first mounting shell 14. A portion of the sample loading structure 10 passes through the interior of the first mounting shell 14, with its second end 12 extending to the exterior of the first mounting shell 14. Thus, the first mounting shell 14 protects the sample loading structure 10, preventing exposure and damage, and also preventing contamination.

[0047] In one embodiment, when loading a reagent test card, the loading method can be either inserting the second end 12 of the loading structure 10 into the sample container according to actual needs, or, in some cases, inserting it vertically or at an angle into the sample solution. Alternatively, the reagent test card can be placed horizontally on the work surface, and the sample solution can be added to the second end 12. The sample solution is then transported to the detection unit 20 via the loading structure 10, enabling a drop-on loading operation and enhancing functionality. Another loading method involves inserting the loading structure 10 of the reagent test card into the sample container, drawing the sample solution into the loading structure 10, and then placing the reagent test card horizontally on the work surface, allowing the sample solution inside the loading structure 10 to enter the detection unit 20.

[0048] Please see Figure 1 , Figures 3 to 5 In one embodiment, the central axis of the sample structure 10 (e.g., Figure 4 (as shown by M in the diagram) and the bottom surface of the first mounting housing 14 (as shown in the diagram). Figure 4The sample loading structure 10 (as shown in the diagram) is angled. The distance between the second end 12 and the bottom surface is greater than the distance between the first end 11 and the bottom surface. Thus, after the sample loading structure 10 is inserted into the sample container to draw the sample solution, when it is placed horizontally on the work surface, the sample loading structure 10 is tilted relative to the bottom surface of the first mounting shell 14, with the second end 12 positioned higher than the first end 11. This allows the sample solution inside the sample loading structure 10 to be gradually and smoothly transported to the detection unit 20 under its own gravity, achieving continuous sample loading and ensuring the loading effect. This meets the requirements of some projects that require horizontal sample loading. Furthermore, it prevents sample solution residue from remaining in the hollow channel 13 of the sample loading structure 10.

[0049] It should be noted that the bottom surface of the first mounting shell 14 refers to the surface on which the first mounting shell 14 is usually placed on the workbench.

[0050] Please see Figure 1 , Figures 3 to 5 In one embodiment, the angle between the central axis of the sample loading structure 10 and the bottom surface of the first mounting shell 14 is defined as α, where α is between 1° and 90°. Thus, after the sample loading structure 10 of the reagent test card is inserted into the sample container to draw the sample solution, when it is placed horizontally on the work surface, the sample solution inside the sample loading structure 10 can gradually flow to the detection unit 20 under its own gravity due to the inclined setting of the sample loading structure 10 relative to the bottom surface of the first mounting shell 14, achieving continuous sample loading and thus ensuring the sample loading effect.

[0051] In one embodiment, α is, for example, 1° to 10°. Specifically, it can be 1°, 2°, 3°, 4°, 5°, 7°, or 10°, or any angle value between 10° and 45° and between 45° and 90° depending on the reagent requirements. Thus, research has found that when the included angle α is set to 1° to 10°, the sample solution inside the sample loading structure 10 can gradually flow to the detection unit 20, achieving continuous sample loading and ensuring the sample loading effect. At the same time, the tilt angle α is not too large, which would result in a large product thickness (i.e., the distance between the two opposite surfaces of the first mounting shell 14 and the distance between the two opposite surfaces of the second mounting shell 15). In other words, setting α to 1° to 10° helps to ensure a smaller product thickness and a smaller product volume, making it easier to carry.

[0052] The first mounting shell 14 can be designed as either a regular or irregular shape, as long as the central axis of the sample mounting structure 10 installed inside it is set at an angle relative to the bottom surface of the first mounting shell 14. Optionally, in this embodiment, the first mounting shell 14 is, for example, a regular-shaped shell, specifically, a square or trapezoidal cross-section along its central axis. In this way, one surface of the first mounting shell 14 serves as the bottom surface, which can fit against the workbench surface, thereby ensuring that the first mounting shell 14 can be placed stably on the workbench surface.

[0053] Please see Figure 1 , Figures 3 to 5 Optionally, the first mounting shell 14 includes two first split shells 141 that are spliced ​​together. Specifically, the two first split shells 141 are detachably connected to each other. Thus, during the assembly process, after the sample structure 10 is installed inside the two first split shells 141, the two first split shells 141 are then connected to each other, which facilitates assembly and maintenance.

[0054] In addition, a bayonet 142 is provided on the end of the first split shell 141 that is away from the detection section 20. The second end 12 of the sample loading structure 10 extends through the bayonet 142 to the outside of the first mounting shell 14 and is locked in the bayonet 142.

[0055] Please see Figure 1 , Figures 3 to 5 In one embodiment, at least one support protrusion 143 is provided on the inner wall of the first mounting shell 14. The support protrusion 143 abuts against the bottom surface of the sample structure 10. The distance between the portion of the sample structure 10 that abuts against the support protrusion 143 and the bottom surface is a first distance, and the distance between the portion of the sample structure 10 that abuts against the detection unit 20 and the bottom surface is a second distance, where the first distance is greater than the second distance. Thus, after the sample structure 10 is installed inside the first mounting shell 14, so that the sample structure 10 abuts against the detection unit 20 and the support protrusion 143 respectively, the sample structure 10 can be arranged at an angle relative to the bottom surface of the first mounting shell 14.

[0056] Optionally, the upper surface of the support protrusion 143 is configured as an arc-shaped surface for the part that comes into contact with the sample structure 10, thereby ensuring that the surface contact between the support protrusion 143 and the sample structure 10 is a line contact. As one of the supports, it is combined with the support of the detection unit 20 for the sample structure 10 to fix the sample structure 10.

[0057] Please see Figures 1 to 5 In one embodiment, the first end 11 of the sample structure 10 is provided with a beveled surface 111 (e.g., angled to its central axis) Figure 3(As shown). The beveled surface 111 is connected to or abuts against the detection section 20. Thus, when the sample loading structure 10 abuts against the detection section 20 through the beveled surface 111, on the one hand, the beveled surface 111 fits perfectly against the detection section 20, which can reduce the risk of sample failure and ensure that as much sample liquid as possible inside the hollow channel 13 flows to the detection section 20, avoiding sample liquid residue, ensuring the sample loading effect, and enabling continuous sample loading; on the other hand, the beveled surface 111 completely rests against the detection section 20, which can ensure the stability of the sample loading structure 10.

[0058] Specifically, when the sample structure 10 is cylindrical, the oblique surface 111 formed on the first end 11 is correspondingly an elliptical surface. In addition, when the sample structure 10 is of other shapes, the oblique surface 111 formed on the first end 11 is adjusted to other shapes accordingly.

[0059] Please see Figure 1 , Figures 3 to 5 In one embodiment, a first positioning component 144 is provided on the inner wall of the first mounting shell 14. The first positioning component 144 is used to hold and position the sample loading structure 10. Thus, since the first positioning component 144 is provided on the inner wall of the first mounting shell 14, the sample loading structure 10 can be held and positioned inside the first mounting shell 14.

[0060] In one embodiment, the sample loading structure 10 includes at least two drainage elements arranged in a row. The outer wall of the drainage elements is hydrophilically modified, and the gap is formed by the spacing between two adjacent drainage elements. Alternatively, the sample loading structure 10 includes at least one drainage element, and the gap is formed on the outer wall of the drainage element. The size of the gap is not limited to 0.1mm-2mm, and can be flexibly adjusted to a value other than 0.1mm-2mm according to actual needs. The length of the gap is not limited to 0.5cm-4cm, and can also be flexibly adjusted to a value other than 0.5cm-4cm according to actual needs. Thus, after the second end 12 of the sample loading structure 10 is inserted into the sample container, the gap can absorb the sample solution and continuously deliver the absorbed sample solution to the detection unit 20, thereby enabling more sample solution to enter the detection unit 20 and ensuring vertical and continuous sample loading.

[0061] Please see Figure 3 In one embodiment, the sample loading structure 10 is provided with at least two hollow channels 13 arranged in a row. Thus, the more hollow channels 13 there are, the more sample solutions can be loaded.

[0062] The specific number of hollow channels 13 can be flexibly adjusted according to actual needs and is not limited here. In this embodiment, the number of hollow channels 13 is determined according to the width of the reagent test card.

[0063] Specifically, the hollow channel 13 can be configured as two, three, four, five, or other quantities. Of course, the hollow channel 13 can also be configured as one.

[0064] Specifically, the sample loading structure 10 includes at least two pipes arranged in a row, thereby forming at least two hollow channels 13. The outer walls of two adjacent pipes are formed with gaps, and due to the hydrophilic modification treatment of the pipe outer wall material, the sample solution can be loaded along the gaps in the outer walls of the two adjacent pipes, ensuring a good loading effect.

[0065] Optionally, the hollow channel 13 may be, but is not limited to, a circular pipe, an elliptical pipe, or a polygonal pipe, etc. It may also be formed by two oppositely arranged hydrophilic plates. As long as the gap between the two hydrophilic plates is small enough, for example, the gap between the hydrophilic plates may be, but is not limited to, 0.1mm-2mm, it can have good capillary adsorption force to achieve water absorption and sample loading effect. In addition, the hollow channel 13 can be flexibly adjusted into other shapes according to actual needs. The specific setting is not limited here.

[0066] Please continue reading. Figure 3 In one embodiment, the sample loading structure 10 can be a capillary tube, comprising one capillary tube or at least two capillary tubes arranged in a row, with a hollow channel located within the capillary tube. The capillary structure sample loading assembly is not only easy to manufacture but also facilitates continuous sample loading.

[0067] Research has shown that adjusting the size of the sample loading structure 10 can correspondingly adjust and control the volume range of the sample solution. Specifically, the size of the sample loading structure 10 can be flexibly adjusted according to the actual volume requirements of various detection projects, so as to adapt to the detection requirements of various detection projects.

[0068] Specifically, the sample loading structure 10 can quantitatively control the sample loading volume by adjusting the pore size and length of the hollow channel 13. The sample loading structure 10 of the reagent card is inserted into the sample solution; specifically, the second end 12 is inserted into the sample solution. After the sample loading structure 10 quickly fills with the sample solution, the reagent card is removed, completing the quantitative sample loading. Alternatively, color markings can be used on the sample loading structure 10, with different colors representing different sample loading volumes. Therefore, the sample solution entering the sample loading structure 10 can be quantified based on the color markings.

[0069] If the sample volume for certain items is large, and specifically exceeds the maximum storage capacity of the hollow channel 13 of the sample loading structure 10, the sample loading structure 10 of the reagent card can be inserted into the sample container containing the sample solution for continuous sample loading. The volume range can be flexibly adjusted by controlling the insertion time into the sample container.

[0070] Please see Figures 1 to 5 In one embodiment, a reagent test card is provided, which includes the sample loading component of the reagent test card of any of the above embodiments, and also includes a detection part 20, with the first end 11 connected to or abutting against the detection part 20.

[0071] The aforementioned reagent test card, on the one hand, allows for more uniform and smoother flow of the sample solution within the hollow channel 13 and / or gaps of the sample loading structure 10, enabling direct sample loading while maintaining the original structure of the detection unit 20. This makes the sample loading operation more convenient and reliable, and can accommodate diverse application scenarios and user groups. On the other hand, it enables residue-free sample loading, ensuring the detection sensitivity and accuracy of the detection unit 20.

[0072] Please see Figure 1 In one embodiment, the reagent test card further includes a second mounting housing 15 connected to the first mounting housing 14. The detection unit 20 is mounted on the second mounting housing 15. Thus, the second mounting housing 15 protects the detection unit 20, preventing it from being exposed and damaged, and also preventing it from being contaminated.

[0073] Specifically, similar to the first mounting shell 14, the second mounting shell 15 includes two second split shells 151 that are spliced ​​together. Specifically, the two second split shells 151 are detachably connected to each other. Thus, during the assembly process, after the detection unit 20 is installed inside the two second split shells 151, the two second split shells 151 are connected to each other, which facilitates assembly and maintenance.

[0074] Please see Figure 1 In one specific embodiment, one of the first split shells 141 is connected to one of the second split shells 151 to form an integrated structure, and the other first split shell 141 is connected to the other second split shell 151 to form an integrated structure.

[0075] Please see Figure 1 In one embodiment, a second positioning component is provided on the inner wall of the second mounting housing 15. The second positioning component is used to hold the positioning detection unit 20 in place. Thus, since the second positioning component is provided on the inner wall of the second mounting housing 15, the detection unit 20 can be held and positioned inside the second mounting housing 15.

[0076] Please see Figure 1 , Figures 3 to 5In one embodiment, the first positioning component 144 includes a first retaining member 1441 and a second retaining member 1442 spaced apart on the inner wall of the first mounting shell 14. The first retaining member 1441 and the second retaining member 1442 respectively abut against two opposite sidewalls of the sample structure 10 to achieve a retaining effect. The first retaining member 1441 is not limited to one, but can be two, and is arranged spaced apart along the length of the first mounting shell 14. Similarly, the second retaining member 1442 is not limited to one, but can be two or more, and is arranged in a one-to-one correspondence with the first retaining member 1441.

[0077] In addition, the first card holder 1441 and the second card holder 1442 are each set to various shapes such as protrusions and protrusions. The specific settings can be flexibly adjusted and set according to actual needs, and are not limited here.

[0078] Similarly, the second positioning component may also include at least one set of retaining members, each set of retaining members including two retaining members arranged at a relative interval, the two retaining members respectively abutting against two opposite side walls of the detection part 20 to achieve the retaining and fixing of the detection part 20.

[0079] In one embodiment, the detection unit 20 includes, but is not limited to, a test strip or other detection structure that can be used to detect reagents. Specifically, the sample loading area of ​​the test strip abuts against the first end 11. Correspondingly, an indicator window is provided on the second mounting housing 15 to indicate whether the reagent strip has been loaded correctly.

[0080] Please see Figure 1 In one embodiment, the reagent test card further includes a protective shell 30. The protective shell 30 is fitted over the outside of the first mounting shell 14 and the second mounting shell 15, serving a protective function. Specifically, the protective shell 30 includes two protective covers 31, one of which covers the outside of the first mounting shell 14, and the other of which covers the outside of the second mounting shell 15.

[0081] The technical features of the above embodiments can be combined in any way. For the sake of brevity, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0082] The embodiments described above are merely illustrative of several implementation methods of this application, and while the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the patent application. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of this application, and these all fall within the protection scope of this application. Therefore, the protection scope of this patent application should be determined by the appended claims.

[0083] In the description of this application, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", "axial", "radial", "circumferential", etc., indicating the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, are only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this application.

[0084] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one of that feature. In the description of this application, "multiple" means at least two, such as two, three, etc., unless otherwise explicitly specified.

[0085] In this application, unless otherwise expressly specified and limited, the terms "installation," "connection," "joining," and "fixing," etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components, unless otherwise expressly limited. Those skilled in the art can understand the specific meaning of the above terms in this application according to the specific circumstances.

[0086] In this application, unless otherwise expressly specified and limited, "above" or "below" the second feature can mean that the first feature is in direct contact with the second feature, or that the first feature is in indirect contact with the second feature through an intermediate medium. Furthermore, "above," "on top of," and "over" the second feature can mean that the first feature is directly above or diagonally above the second feature, or simply that the first feature is at a higher horizontal level than the second feature. "Below," "below," and "under" the second feature can mean that the first feature is directly below or diagonally below the second feature, or simply that the first feature is at a lower horizontal level than the second feature.

[0087] It should be noted that when an element is referred to as being "fixed to" or "set on" another element, it can be directly on the other element or there may be an intervening element. When an element is considered to be "connected to" another element, it can be directly connected to the other element or there may be an intervening element. The terms "vertical," "horizontal," "upper," "lower," "left," "right," and similar expressions used herein are for illustrative purposes only and do not represent the only possible implementation.

Claims

1. A reagent test card, characterized by, The reagent detection card comprises a sample loading assembly and a detection part. The sample loading structure is provided with opposite first and second ends, and the first end is connected with the detection part or abuts against each other. The sample loading structure is provided with at least two flow guides arranged in a row, and the outer wall of the flow guide is treated by hydrophilic modification, and adjacent two flow guides are arranged at intervals to form a gap, and the gap extends from the first end to the second end, and the wall surface of the gap is treated by hydrophilic modification and is smooth. The aperture of the hollow channel or the size of the gap is 0.1mm-2mm; the length of the hollow channel or the length of the gap is 0.5cm-4cm; the sample loading assembly of the reagent detection card further comprises a first mounting shell; the central axis of the sample loading structure is arranged at an angle with the bottom surface of the first mounting shell, and the angle between the central axis of the sample loading structure and the bottom surface of the first mounting shell is defined as a, and a is 1° to 10°.

2. The reagent test card of claim 1, wherein, The sample loading structure is partially arranged in the interior of the first mounting shell, and the second end extends to the exterior of the first mounting shell.

3. The reagent test card of claim 2, wherein, The distance between the second end and the bottom surface is greater than the distance between the first end and the bottom surface.

4. The reagent test card of claim 3, wherein The first mounting shell comprises two first sub-hulls connected with each other.

5. The reagent test card of claim 3, wherein The inner wall of the first mounting shell is provided with at least one supporting convex part, and the supporting convex part abuts against the bottom surface of the sample loading structure, the distance from the part of the sample loading structure abutting against the supporting convex part to the bottom surface is a first distance, and the distance from the part of the sample loading structure abutting against the detection part to the bottom surface is a second distance, and the first distance is greater than the second distance.

6. The reagent test card of claim 5, wherein, The upper surface of the supporting convex part is arranged as an arc surface.

7. The reagent test card of claim 2, wherein, The inner wall of the first mounting shell is provided with a first positioning assembly for clamping and positioning the sample loading structure.

8. The reagent test card of claim 1, wherein, The sample loading structure is provided with at least two hollow channels arranged in a row; or the sample loading structure is provided with one capillary or at least two capillaries arranged in a row, and the capillary is provided with the hollow channel.

9. The reagent test card of claim 1, wherein, The reagent detection card further comprises a second mounting shell connected with the first mounting shell, and the detection part is arranged in the second mounting shell.

10. The reagent test card of claim 9, wherein, The inner wall of the second mounting shell is provided with a second positioning assembly for clamping and positioning the detection part.

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