A super amphiphilic molecule for enhancing dynamic and static deposition of droplets and a preparation method thereof

Abstract

The present invention provides a super-amphiphilic molecule for enhancing the dynamic and static deposition of droplets, which is self-assembled by a main molecule Alg-CD and a guest molecule Azo-DEMA. The present invention is prepared by self-assembly of a super-amphiphilic host-guest complex between an amphiphilic cyclodextrin functionalized alginate derivative (Alg-CD) and an azobenzene derivative (Azo-DEMA), and a comprehensive super-amphiphilic molecule is developed, which can improve the droplet deposition behavior, and also adjust the wettability in static deposition, thereby enhancing the anchoring of the droplet on the hydrophobic surface, improving the pesticide effect, and making the pesticide have a sensitive drug effect under ultraviolet irradiation or natural sunlight. For example, in a specific embodiment, the super-amphiphilic molecule of the present invention is added to the oxyfluorfen aqueous emulsion as an adjuvant, which can improve the drug effect and also has a sensitive weeding effect under ultraviolet irradiation or natural sunlight.

Description

Technical Field

[0001] The invention relates to a super amphiphilic molecule, in particular to a super amphiphilic molecule capable of enhancing dynamic and static deposition of droplets and a preparation method thereof. Background Art

[0002] Surfactants are indispensable ingredients in the preparation of pesticide adjuvant formulations due to their good emulsification, dispersibility and wettability. However, the use of chemical surfactants in industry still has potential environmental and toxicity issues. It is well known that pesticide spraying is a hard agricultural work. When pesticide droplets are sprayed on target plants, some undesirable loss behaviors, such as inevitable splashing and bouncing during the impact process, will lead to pesticide waste and reduce its performance and efficiency, thereby reducing the utilization effect of pesticides and increasing the risk to non-target environments. Therefore, it is very necessary to develop pesticide formulations that minimize adverse effects on the environment while maximizing efficacy.

[0003] At present, there are two common strategies, namely, adding single additives, such as flexible polymers or small molecule surfactants, to suppress droplet bouncing and splashing and enhance dynamic deposition. For example, some small amounts of polymers (e.g., poly(ethylene oxide) (PEO)) can promote high elongational viscosity and suppress the breakup of impact droplets during impact. It is reported that oppositely charged polyelectrolytes (polyethyleneimine and polyacrylic acid, chitosan and alginate) can enhance droplet deposition by in situ forming hydrophilic defects on hydrophobic surfaces. In addition, the addition of surfactants is considered to be a simple way to improve droplet retention. For example, Wang et al.'s research group provided a sustainable and innovative pesticide formulation that relied on nanoscale worm-like micelle networks and surfactant coacervates to suppress droplet splashing and maintain long-term resistance to wind and rain erosion. It is worth noting that effective wetting and spreading on plant surfaces are also crucial to determine static deposition behavior and improve the utilization of pesticide droplets. Existing strategies to reduce pesticide losses and environmental pollution still cannot work effectively in two or more aspects of all pesticide application stages. It remains a huge challenge to find suitable additives to solve the bounce and splash of dynamic impact processes and the static wetting and spreading. Recently, polymer surfactants have been used to develop agrochemical carriers and agricultural adjuvants due to their nontoxicity, good biocompatibility, good amphiphilicity, and strong self-assembly ability. Therefore, we hypothesized that it would be very important if macromolecular adjuvants that combine polymers and small-molecule surfactants with desired properties could be developed, which could be applied in various stages of agrochemical application and improve the efficacy of agrochemical formulations. Summary of the invention

[0004] The purpose of the present invention is to overcome the deficiencies in the prior art and provide a super amphiphilic molecule for enhancing dynamic and static deposition of droplets and a preparation method thereof.

[0005] The first aspect of the present invention is to provide a super amphiphilic molecule for enhancing dynamic and static deposition of droplets, which is self-assembled by a main molecule Alg-CD and a guest molecule Azo-DEMA, wherein the structural formula of Alg-CD is shown in formula (1), and the structural formula of Azo-DEMA is shown in formula (2):

[0006]

[0007] Preferably, the ratio of the host molecule Alg-CD to the guest molecule Azo-DEMA is 1 g:5 mmol<Alg-CD:Azo-DMEA<1 g:8 mmol.

[0008] More preferably, the ratio of the host molecule Alg-CD to the guest molecule Azo-DEMA is 1 g:6 mmol.

[0009] The second aspect of the present invention is to provide a supra-amphiphilic molecule aqueous solution, which is an aqueous solution containing the supra-amphiphilic molecule described in the first aspect of the present invention.

[0010] Preferably, in the supra-amphiphilic molecule aqueous solution, the concentration of the main molecule Alg-CD is 0.5-2 g / L.

[0011] Preferably, the concentration of the host molecule Alg-CD is 1 g / L, and the concentration of the guest molecule Azo-DEMA is 6 mmol / L.

[0012] The aqueous phase may be a common aqueous phase for preparing a solution or an emulsion, and the present invention is not particularly limited here, and those skilled in the art may reasonably select it according to the needs of practical applications. Preferably, the aqueous phase includes any one of water, phosphate buffer, acetate buffer, citrate buffer or Tris buffer, or a mixture of at least two thereof.

[0013] Preferably, the aqueous phase also includes other water-soluble substances, which are any one of salts, antibodies, protein polypeptide drugs, enzymes, cytokines or sugars, or a mixture of at least two of them. The salt substances are sodium chloride, sodium acetate, potassium chloride, calcium chloride, etc.

[0014] The third aspect of the present invention is to provide a method for preparing the supra-amphiphilic molecule as described in the first aspect of the present invention, wherein an aqueous solution of a main molecule Alg-CD and an aqueous solution of a guest molecule Azo-DMEA are mixed, and Alg-CD and Azo-DMEA are self-assembled to obtain the result.

[0015] The fourth aspect of the present invention is to provide a drug delivery system, using the supra-amphiphilic molecule described in the first aspect of the present invention as an auxiliary agent.

[0016] The fifth aspect of the present invention is to provide the use of the supra-amphiphilic molecule as described in the first aspect of the present invention, or the supra-amphiphilic molecule aqueous solution as described in the second aspect of the present invention, or the drug delivery system as described in the fourth aspect of the present invention, which is used in the fields of biomedicine, cosmetics, food, petroleum and wastewater treatment.

[0017] The sixth aspect of the present invention is to provide the use of the supra-amphiphilic molecules as described in the first aspect of the present invention, or the supra-amphiphilic molecule aqueous solution as described in the second aspect of the present invention in suppressing splashing and bouncing during the dynamic impact process of droplets, and / or adjusting the static wettability of droplets, and enhancing the anchoring of droplets on hydrophobic surfaces.

[0018] The seventh aspect of the present invention is to provide the use of the supra-amphiphilic molecule as described in the first aspect of the present invention, or the supra-amphiphilic molecule aqueous solution as described in the second aspect of the present invention, or the drug delivery system as described in the fourth aspect of the present invention in improving the effect of pesticides and / or preparing pesticides with sensitive efficacy under ultraviolet irradiation or natural sunlight.

[0019] For example, in a specific embodiment of the present invention, the super-amphiphilic molecule solution loaded with herbicides is sensitive to the application of ultraviolet irradiation or natural sunlight to improve the weed control effect. It should be understood that this is only an example, and the present invention is not limited to the specific embodiments described above. For those skilled in the art, the super-amphiphilic molecule of the present invention can also be used in combination with other pesticides to inhibit the splashing and bouncing of pesticide droplets, avoid splashing and bouncing to cause pesticide waste and reduce its performance and efficiency, and at the same time adjust the static wettability of the droplets, enhance the anchoring of the droplets on the hydrophobic surface, thereby improving the utilization rate of the pesticide droplets and ultimately improving the pesticide effect.

[0020] The present invention develops a comprehensive super-amphiphilic molecule through the self-assembly preparation of a super-amphiphilic host-guest complex between an amphiphilic cyclodextrin functionalized alginate derivative (Alg-CD) and an azobenzene derivative (Azo-DEMA), which can improve the droplet deposition behavior and regulate the wettability in static deposition, thereby enhancing the anchoring of the droplet on the hydrophobic surface, improving the pesticide effect, and making the pesticide have a sensitive drug effect under ultraviolet irradiation or natural sunlight. For example, in a specific embodiment, adding the super-amphiphilic molecule of the present invention as an adjuvant to the ethosulfate aqueous emulsion can improve the drug effect and also have a sensitive weeding effect under ultraviolet irradiation or natural sunlight. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 This is a graph of the macroscopic changes of the micelle solution with time and different guest molecule concentrations. In the figure, 1, 2, 4, 6, 8, and 10 represent guest molecule concentrations of 1mmol / L, 2mmol / L, 4mmol / L, 5mmol / L, 6mmol / L, 8mmol / L, and 10mmol / L, respectively.

[0022] Figure 2 (a) Schematic diagram of light-driven micellar superamphiphilic self-assembly; (b) UV-visible absorption spectrum of micelles under UV or vis irradiation; (c) ratio of fluorescence intensity of pyrene in SAs solution under UV or vis irradiation for different time periods; (d) fluorescence intensity ratio of the composite solution after cyclic irradiation of UV and visible light; (e) Tyndall effect of micelles before and after UV irradiation; (f) TEM image of micelles; (g) change in the size of micelles under dark or UV irradiation.

[0023] Figure 3 Impact experiments of droplets on superhydrophobic surfaces: (a) water; (b) SAs additive solution; (c) Oxy EW and (d) Oxy EW+SAs.

[0024] Figure 4 (a) Viscosity of SAs under different light conditions; (b) Equilibrium surface tension (EST) of Azo-DMEA and SAs solutions; (c) Changes in DCA of SAs on a hydrophobic leaf surface before and after UV irradiation; (d) Schematic diagram of the change in contact angle of a pesticide droplet on a hydrophobic surface irradiated with UV; (e) Digital photograph of the droplet contact angle.

[0025] The figure shows the photos of weeds (Echinochloa crus-galli) treated with 5 water, Oxy EW, and Oxy EW+SAs, with the pesticide dosage of 0.24 mg / mL.

[0026] Figure 6 (a) SEM images of weeds before and after SAs treatment (9 days); (b) Effects of water, Oxy EW, OxyEW+SAs without UV treatment, UV treatment, and sunlight treatment on the height of weeds (Echinochloa crus-galli) at a dose of 0.24 mg / mL; (c) Weed control effect (mortality). DETAILED DESCRIPTION

[0027] The present invention will be further described below with reference to the accompanying drawings in conjunction with specific embodiments to better understand the present invention. Where specific techniques or conditions are not indicated in the embodiments, the techniques or conditions described in the literature in this area or the product specifications are used. Where the manufacturer of the reagents or instruments used is not indicated, they are all conventional products that can be obtained commercially.

[0028] 1. Synthesis of sodium alginate-based host molecules

[0029] First, 80 ml of sodium alginate solution (2.5 wt%) was adjusted to pH 3.6 and diluted to a concentration of 2 wt %, then formaldehyde (1.8 mmol), mono (6-amino-6-deoxy) -β-CD (1.3 mmol) aqueous solution and cyclohexyl isocyanide (1.8 mmol) were added to the solution, and the mixture was stirred at room temperature for 24 hours. The crude product was dialyzed with distilled water for 3 days and further freeze-dried to obtain the Alg-CD product. 1 H NMR (400MHz, D2O): δ = 5.00 (s; H of β-CD), 4.11-3.54 (br, m; H of β-CD), 1.75-1.52, 1.1 (m; C6H 11 ).

[0030] 2. Synthesis of azophenyl surfactants

[0031] The synthesis process of Azo-DMEA is as follows. First, 4-phenylazophenol (25 mmol) and 1,2-dibromoethane (0.23 mol) were dissolved in acetonitrile. Then, anhydrous K2CO3 (0.09 mol) and 18-Crown-6 (4.8 mmol) were added to the mixture under N2 protection and refluxed for 40 hours. After removing the solvent, the mixture was purified by silica gel column chromatography with a mixed solvent (ethyl acetate / petroleum ether) to obtain a pure yellow powder (Azo-Br, yield 91.2%).

[0032] Excess DMEA was added to the Azo-Br / acetonitrile solution for the synthesis of Azo-DMEA. The reaction solution was stirred at 75 °C for 24 hours under N2 protection. After removing acetonitrile and DMEA, the crude product was added to ethyl acetate, filtered to obtain a bright orange solid, and dried in a vacuum oven to obtain a purified sample. Azo-Br: 1 H NMR (400MHz, DMSO-d6), δ = 7.93 (d, 2H, Ph-H), 7.88 (d, 2H, Ph-H), 7.51 (t, 2H, Ph-H), 7 .46(d,1H,Ph-H),7.03(d,2H,Ph-H),4.38(t,2H,-CH2),3.69(t,2H,-CH2).Azo-DMEA: 1H NMR (400MHz, DMSO-d6), δ = 7.95 (d, 2H, Ph-H), 7.86 (d, 2H, Ph-H), 7.59 (t, 2H, Ph-H), 7.55 (d, 1H, Ph-H), 7.21 (d,2H,Ph-H),5.35(t,1H,-OH),4.59(t,2H,-CH2),3.90(t,4H,-CH2),3.55(t,2H,-CH2),3.22(s,6H,-CH3).

[0033] 3. Preparation of super-amphiphilic molecular system

[0034] Prepare an aqueous solution of the host molecule Alg-CD with an appropriate concentration; prepare an aqueous solution of the guest molecule Azo-DMEA with an appropriate concentration.

[0035] The main molecule Alg-CD aqueous solution and different amounts of the guest molecule Azo-DMEA aqueous solution were mixed to obtain different guest molecule concentrations. Super amphiphilic molecule aqueous solution, each The concentration of the host molecule Alg-CD in the supraamphiphilic molecule aqueous solution was 1 g / L, and the concentrations of the guest molecule Azo-DMEA were 1 mmol / L, 2 mmol / L, 4 mmol / L, 5 mmol / L, 6 mmol / L, 8 mmol / L and 10 mmol / L, respectively.

[0036] The various The super amphiphilic molecule aqueous solution was placed for 7 days. Figure 1 As shown in the figure, the sample with a guest molecule concentration of 6 mmol / L remained in its original state after being stored for 7 days, showing better stability. Aqueous solutions of super-amphiphilic molecules (hereinafter referred to as SAs) were used for subsequent experiments.

[0037] 4. Physicochemical properties and morphology of superamphiphilic assemblies

[0038] Monitoring the ultraviolet-visible absorption of the super amphiphilic molecules (SAs) of the present invention under UV or vis irradiation shows that the host-guest complex can well realize the photoisomerization transition between trans and cis ( Figure 2 b) This indicates that the supra-amphiphilic molecule of the present invention has photoresponsiveness.

[0039] The I1 / I3 value of the supra-amphiphilic molecule (SAs) of the present invention was determined by the fluorescent pyrene probe method. 10 nmol pyrene / ethanol solution was added to a test tube, the solvent was evaporated by nitrogen, and the sample (SAs) was placed in the test tube for fluorescence testing. Test conditions: All solutions were oscillated at a constant temperature of 25°C for 12 hours, the excitation wavelength was 335 nm, the emission spectrum was in the range of 345-600 nm, and the slit width was 2.5 nm. The results are shown in Figure 2 As shown in Fig. 3c, after UV irradiation for 120 s, the I1 / I3 value increased from 1.13 to 1.60, indicating an enhanced polarity. However, after visible light irradiation for 120 s, the I1 / I3 value dropped almost to the initial value (~1.17). In addition, the I1 / I3 data of the supramolecular complex solution can be well repeated several times under UV and visible light irradiation, and the amphiphilicity can be significantly changed by light irradiation, indicating that the hydrophilic-hydrophobic balance is adjustable ( Figure 2 d), indicating that the super-amphiphilic molecule of the present invention has adjustable amphiphilicity.

[0040] The self-assembly behavior of the supraamphiphilic molecules of the present invention was demonstrated by TEM. Figure 2 f describes the reversible photocontrollable assembly of supraamphiphiles (SAs) by TEM. Before UV irradiation, the host and guest molecules can assemble into spherical structures. After UV irradiation, the number of self-assemblies is significantly reduced, and the Tyndall effect is weakened ( Figure 2 e), indicating that the complex disintegrated. However, the host-guest complex recovered again under visible light irradiation ( Figure 2 f). Therefore, by using azo-based small molecule surfactants as molecular triggers, light-controlled assembly and tunable amphiphilic balance of the assemblies were achieved.

[0041] We further studied the structural stability of the supraamphiphilic molecules using dynamic light scattering (DLS). Figure 2 As shown in Figure g, the particle size distribution of the host-guest complex is narrow, with an average size of 161.2 nm. In addition, the initial value of the zeta potential test was -24.97 mV, and it remained at -22.30 mV after storage for 4 months, indicating that the supra-amphiphilic molecular solution exhibited good colloidal stability (Table 2). After UV irradiation, the particle size of the supra-amphiphilic molecular assembly increased significantly over time. In addition, after storage in the dark for 10 minutes, the particle size remained almost unchanged. After 7 and 30 days of storage, the particle size and polydispersity index (PDI) increased slightly (Table 1), which confirmed that the super-amphiphilic molecular assembly had good structural stability in the dark.

[0042] Table 1 Stability of superamphiphilic molecular self-assembly in water

[0043]

[0044] Table 2 Zeta potential of supraamphiphilic molecular self-assemblies

[0045]

[0046] 5. SAs additives inhibit splashing of droplets on hydrophobic surfaces

[0047] Oxyfluorfen emulsion in water (Oxy EW, 0.24 mg / mL) was prepared in the laboratory.

[0048] A certain dose of 100 g / L Oxy emulsifiable concentrate pesticide preparation was mixed with an appropriate concentration of the main molecule Alg-CD aqueous solution and an appropriate concentration of the guest molecule Azo-DMEA aqueous solution to prepare an Oxy EW+SAs pesticide solution, so that the concentration of the active ingredient of the pesticide in the pesticide droplet system was 0.24 mg / mL, the concentration of Alg-CD was 1 g / L, and the concentration of Azo-DMEA was 6 mmol / L.

[0049] Water, SAs, Oxy EW, and Oxy EW+SAs were used to simulate the pesticide spraying process. All samples were diluted 2 times for impact test (considering that pesticide formulations need to be diluted in actual applications, the solution was diluted and tested only for this bounce test, and other experiments were not diluted). All droplets fell vertically onto the modified SiO2 superhydrophobic surface at the same initial height (17 cm) to ensure that they had the same impact speed. A high-speed camera (i-SPEED 220, Suzhou) was used to capture the bouncing behavior of droplets (water, SAs, Oxy EW, Oxy EW+SAs) on the modified SiO2 superhydrophobic surface from the side.

[0050] like Figure 3 As shown in a, when a water droplet hits a super-hydrophobic surface, due to inertial force, the water droplet splits into many droplets and flies off the surface. After adding SAs, the droplets exhibit different behaviors. The droplets show the extension characteristics of macromolecular polymers and completely retract, effectively suppressing splashing ( Figure 3 b) Compared with pure water droplets, although Oxy EW (COxy = 0.24 mg / mL) (see Figure 3 c) has a shorter anchoring time on the surface (65.8 ms) but still shows some splashing. In contrast, after adding photoresponsive SAs ( Figure 3 d), the droplet anchors on the surface earlier (58.9ms). Figure 3 b and Figure 3 d) There is no loss such as splashing.

[0051] We also measured the viscosity of the liquid. Figure 4In a, the shear viscosity of the SAs solution before and after illumination (initial viscosity is 1530mPa·s and 1689.77mPa·s, respectively) is much higher than the shear viscosity of the aqueous solution (~1mPa·s). The SAs solution before and after UV irradiation exhibits similar viscosity and shear thinning behavior, indicating that the addition of SAs significantly increases the viscosity of the bulk phase, while the Azo molecules dissociated from the cyclodextrin cavity after UV irradiation do not affect the viscosity of the bulk phase. The viscous effect and ductility can play a good role in reducing splashing. Based on the above results, it is concluded that the photoresponsive SAs additive of the present invention has the ability to suppress splashing during dynamic impact and enhance surface pinning.

[0052] 6. Static deposition of SAs droplets on hydrophobic leaves

[0053] The host-guest additive droplets were slowly dropped onto the leaf, the equilibrium surface tension (EST) of the droplets was measured, and the contact angle of the droplets on the leaf was measured using a contact angle meter.

[0054] The contact angle is considered an indicator of the wetting and spreading behavior of static droplets on solid surfaces. In order to improve wettability and prevent splashing of droplets during spraying, it is necessary to reduce surface tension and increase polarity. The changes in surface tension of SAs before and after UV irradiation are shown in Figure 2. Figure 4 As shown in Figure b, after adding Alg-CD, the SAs solution showed a higher EST of 44.58 mN / m. After UV irradiation, the EST value dropped to 37.15 mN / m. The low surface tension showed that the SAs after UV had better surface activity, indicating that the SAs of the present invention played a role in static wetting and spreading on the hydrophobic surface.

[0055] In fact, the wetting process of pesticide droplets on plant surfaces is a dynamic process. Therefore, we further studied the dynamic contact angle (DCA) within 120s and the spreading effect of Oxy EW-SAs solution on hydrophobic surfaces, such as Figure 4 As shown in (c, e), SAs additives were mixed with Oxy EW to prepare pesticide formulations (C Oxy =0.24 mg / mL, Alg-CD concentration of 1 g / L, Azo-DMEA concentration of 6 mmol / L), and the droplets were then dropped on the leaves. Over time, the DCA value of the sample without UV irradiation dropped to 63.71°, while the DCA value of the sample after UV irradiation dropped to 49.94°. This shows that the SAs of the present invention interact with the solid surface to change the surface wettability and anchor on the surface. Based on the results summarized above, the constructed SAs adjuvant system can play a role in both dynamic and static deposition in the agricultural application stage.

[0056] 7. Herbicidal activity of agricultural chemicals with SAs as adjuvants

[0057] After fully demonstrating the various properties of SAs, we turned to the study of their herbicidal activity in order to better evaluate the light control effect in actual agricultural production. Barnyardgrass is considered to be one of the most harmful and troublesome weeds in rice fields, and oxyfluorfen has shown good herbicidal effects on barnyardgrass. The Oxy EW+SAs prepared in "5. SAs additives inhibit splashing of droplets on hydrophobic surfaces" was used for the experiment. The herbicidal activity of the light-responsive pesticide system was studied in a pot experiment, and the herbicidal activity was compared with water and OxyEW (C Oxy =0.24 mg / mL) for comparison.

[0058] The results are as follows Figure 5 As shown. In the first five days, there was little difference in the weed control effect between water and Oxy EW. Under UV irradiation, the control effect of the solution containing SAs adjuvant was significantly improved. Except for the control group (water), the other four groups of grass showed signs of complete dryness and necrosis 9 days after administration. It was found that the weed control rate of grass treated with Oxy-SAs and UV remained ahead and significantly higher than that of grass not treated with light ( Figure 6 (a, b)). Subsequently, in order to test whether the system can work in a natural environment, we conducted a weed control experiment under natural sunlight. Within the first 3 days after treatment, the mortality rate of weeds under UV and sunlight irradiation continued to increase. At the same time, at the same dose, the weed control activity of grass under UV and sunlight showed a superior weed control effect than that without UV irradiation ( Figure 6 b). However, the first obvious signs of necrosis were observed in the grass treated with sunlight 5 days after treatment, showing a slightly delayed effect than the grass treated with UV light. The slightly delayed control effect may be due to the weaker UV intensity of the sunlight source, which also indicates that the different control effects have good photosensitivity to weed control.

[0059] The specific embodiments of the present invention are described in detail above, but they are only examples, and the present invention is not limited to the specific embodiments described above. For those skilled in the art, any equivalent modification and substitution of the practical is also within the scope of the present invention. Therefore, the equalization transformation and modification made without departing from the spirit and scope of the present invention should be included in the scope of the present invention.

Claims

1. A super amphiphilic molecule for enhancing dynamic and static deposition of droplets, characterized in that: It is self-assembled by the main molecule Alg-CD and the guest molecule Azo-DEMA, wherein the structural formula of Alg-CD is shown in formula (1), and the structural formula of Azo-DEMA is shown in formula (2):

2. The super amphiphilic molecule according to claim 1, characterized in that The ratio of the main molecule Alg-CD to the guest molecule Azo-DEMA is 1 g:5 mmol<Alg-CD:Azo-DMEA<1 g:8 mmol.

3. The super amphiphilic molecule according to claim 2, characterized in that The ratio of the host molecule Alg-CD to the guest molecule Azo-DEMA was 1 g:6 mmol.

4. A supra-amphiphilic molecule aqueous solution, characterized in that: The invention is an aqueous solution containing the supra-amphiphilic molecule according to any one of claims 1 to 3.

5. The supra-amphiphilic molecule aqueous solution according to claim 4, characterized in that: The concentration of the main molecule Alg-CD is 0.5-2 g / L.

6. The supra-amphiphilic molecule aqueous solution according to claim 5, characterized in that The concentration of the host molecule Alg-CD was 1 g / L, and the concentration of the guest molecule Azo-DEMA was 6 mmol / L.

7. A method for preparing a supra-amphiphilic molecule according to any one of claims 1 to 3, characterized in that: The main molecule Alg-CD aqueous solution and the guest molecule Azo-DMEA aqueous solution are mixed, and the self-assembly of Alg-CD and Azo-DMEA is obtained.

8. A drug delivery system, characterized in that: The super amphiphilic molecule described in any one of claims 1 to 3 is used as an auxiliary agent.

9. Use of the supra-amphiphilic molecule according to any one of claims 1 to 3, or the supra-amphiphilic molecule aqueous solution according to claim 4 or 5, or the drug delivery system according to claim 8 in the fields of biomedicine, cosmetics, food, petroleum and wastewater treatment.

10. Use of the supra-amphiphilic molecule according to any one of claims 1 to 3, or the supra-amphiphilic molecule aqueous solution according to claim 4 or 5, in suppressing splashing and bouncing during dynamic impact of droplets, and / or adjusting the static wettability of droplets, and enhancing the anchoring of droplets on hydrophobic surfaces.

11. Use of the supra-amphiphilic molecule according to any one of claims 1 to 3, or the supra-amphiphilic molecule aqueous solution according to claim 4 or 5, or the drug delivery system according to claim 8 in improving the effect of pesticides and / or preparing pesticides that exert sensitive efficacy under ultraviolet irradiation or natural sunlight.

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