A magnetically controlled micro-nanoparticle device with positioning / treatment functions

Abstract

The present invention relates to the field of medical device technology, and in particular to a magnetically regulated micro-nanoparticle device with positioning / treatment functions, which includes a bracket, a rotating magnet device disposed on the bracket, a mobile platform for controlling the bracket to move in space, a positioning device disposed on a protective shell of the rotating magnet device, and a manipulation device for controlling the operation of the entire magnetically regulated micro-nanoparticle device. The present invention provides a magnetically regulated micro-nanoparticle device with positioning / treatment functions, which is used to achieve precise control of the movement of micro-nanoparticles in the body, and at the same time has a positioning function in radiotherapy, providing important support for precise diagnosis and treatment, and has the characteristics of being non-invasive, rapid, precise, efficient, stable and safe, and brings changes to human health care in terms of precision medicine. The auxiliary treatment instrument provided increases the future market application rate of the present invention.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to a positioning and guiding device. Background Art

[0002] Magnetic control micro-nanoparticles have a wide range of applications in biomedicine, especially in drug delivery. Drugs can be loaded onto micro-nanoparticles by physical loading or chemical connection, and active targeted drug transport can be achieved under the control of a magnetic field to enhance the therapeutic effect. However, due to the small size of micro-nanoparticles, the drug loading capacity of a single micro-nanoparticle is limited, and the clustering and control of a large number of micro-nanoparticles is usually required to complete a specific task. The current magnetic control device can achieve nanoparticle aggregation and movement by adjusting the magnetic field type and magnetic field parameters, and experiments have been conducted in vitro.

[0003] Chinese patent CN215924392U discloses a magnetic nanoparticle control device, including a bracket, a rotating magnet device arranged on the bracket, and a mobile platform for controlling the bracket to move in space. The rotating magnet device includes a rotating motor and a permanent magnet arranged on the shaft of the rotating motor. The technical solution adopted by this practical invention can accurately control the position of the strongest point of the magnetic field intensity of the magnetic field generated by the rotating magnet device in space, thereby realizing the displacement control of magnetic nanoparticles, but cannot realize cluster control and precise guidance of magnetic nanoparticles. The present invention provides a magnetic control micro-nanoparticle device with positioning / treatment function, which can realize cluster control and precise guidance of magnetic nanoparticle movement. Summary of the invention

[0004] Based on the existing technology, the magnetic field of the magnetically regulated micro-nanoparticle device is limited in its effective area and cannot cover the entire effective area. When the drug-loaded magnetically regulated micro-nanoparticles are injected into the body, if they are not within the range of the magnetic field, precise regulation cannot be achieved; and after the micro-nanoparticles are injected into the body, due to their small size, they are not visible in the imaging field and cannot be quickly tracked.

[0005] To solve the above problems, the present invention adopts the following technical solution: the present invention provides a magnetically controlled micro-nanoparticle device with positioning / treatment function, which can realize the aggregation of micro-nanoparticles at the target positioning point, help to quickly locate the area where the nanoparticles gather in the body, and help other image tracking devices such as ultrasound, X-ray, etc. to quickly find the target monitoring area.

[0006] The magnetically regulated micro-nano particle device with positioning / treatment function comprises a bracket, a rotating magnet device arranged on the bracket, the rotating magnet device comprises a rotating magnet, a rotating motor and its shell, a mobile platform for controlling the bracket to move in space, a positioning device arranged on the shell of the rotating magnet device and a manipulation device for controlling the operation of the entire magnetically regulated micro-nano particle device.

[0007] The positioning device is arranged on the housing of the rotating magnet device, and is composed of two or more positioning instruments with positioning functions, and the positioning instruments are selected from laser positioning instruments, infrared positioning instruments, ultrasonic positioning instruments, etc., preferably laser positioning instruments. The positioning device emits corresponding light or sound waves to guide the magnetic control device to focus the micro-nano particles to the target positioning point. The intersection point of the light or sound waves emitted by the positioning instrument falls on the center of the magnetic field formed by the rotating magnet on the surface of the target object.

[0008] Furthermore, a plurality of light rays or sound waves are emitted by the positioning device, and the intersection of the plurality of light rays or sound waves is determined as the target positioning area, thereby achieving the purpose of quickly determining the target area.

[0009] Furthermore, the angle between the locators is 90 degrees, and the locators and the housing of the rotating magnet device are inclined at a 45 degree angle.

[0010] Furthermore, the laser locator is composed of a laser positioning light group.

[0011] Furthermore, the laser positioning light group may be one or more, preferably two.

[0012] Furthermore, an auxiliary treatment device may be arranged on the housing of the magnetic control device. In a specific embodiment, the auxiliary treatment device is a laser thermal treatment device.

[0013] The bracket can be a C-shaped bracket or a U-shaped bracket.

[0014] The rotating magnet device is respectively installed at both ends of the bracket. The rotating magnet device includes a rotating motor and a rotating magnet arranged on the shaft of the rotating motor. The rotating motor drives the rotating magnet to rotate.

[0015] Furthermore, the rotating magnet is placed in the rotating magnet device, and the outer shell of the rotating magnet device is provided with a positioning device for assisting in guiding the movement of the magnetically regulated nanoparticles.

[0016] A bracket sleeve is provided on the mobile platform, the bracket passes through the bracket sleeve, and a motor gear transmission device is provided in the bracket sleeve. Correspondingly, an arc-shaped rack matching the motor gear transmission device is provided on the connecting side of the bracket and the motor gear transmission device, and the bracket rotates under the drive of the motor gear transmission device.

[0017] Furthermore, the mobile platform may be a three-axis mobile platform, which can realize the movement of the bracket in three-dimensional space of X-axis, Y-axis and Z-axis.

[0018] Furthermore, the mobile platform is controlled by a stepper motor.

[0019] The rotating magnet device, the moving platform and the positioning device are electrically connected to the operating device.

[0020] The operating device is composed of a control device group and a control panel.

[0021] The control device group is composed of a motor controller and a switching power supply.

[0022] The control panel consists of a control button group and a display.

[0023] Furthermore, in a specific embodiment, the control button group is provided with an emergency stop button, a pause button, a switch button, and a rotation direction button and a rotation speed button for controlling the rotating motor.

[0024] The display can display information such as the real-time rotation speed and rotation direction of the rotating motor.

[0025] The magnetically controlled micro-nano particle device with positioning / treatment function of the present invention can be handheld or fixed on other devices such as a mechanical arm to achieve automated operation.

[0026] The technical solution adopted by the present invention has the following beneficial effects:

[0027] In the technical solution adopted by the present invention, a positioning device is used to guide the fixed-point aggregation movement of magnetically regulated nanoparticles, which provides a technical solution to solve the problem of driving magnetic carriers in deep areas of the body. Micro-detection or treatment tools are efficiently transported to the lesion site through non-invasive methods, providing important support for precise diagnosis and treatment. It has the characteristics of non-invasive, rapid, precise, efficient, stable and safe. At the same time, the auxiliary treatment instruments provided can help patients receive photothermal treatment. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] Figure 1 This is an overall schematic diagram of a magnetically regulated micro-nanoparticle device with positioning / therapeutic functions.

[0029] Figure 2 Schematic diagram of the interior of the rotating magnet device in the magnetically regulated micro-nanoparticle device with positioning / treatment functions.

[0030] Figure 3 Schematic diagram of the exterior and interior of the manipulator in a magnetically regulated micro-nanoparticle device with positioning / treatment functions.

[0031] Figure 4 Laser-guided micro-nanoparticle aggregation and motion diagram for magnetically regulated micro-nanoparticle devices with localization / therapeutic functions.

[0032] The attached drawings indicate: 1-bracket; 2-rotating magnet device; 3-moving platform; 4-positioning device; 51-laser positioning light-1; 52-laser positioning light-2; 6-bracket sleeve; 7-motor gear transmission device; 8-arc rack; 9-rotating motor; 10-operating device; 11-rotating magnet; 12-control panel; 13-control device group; 14-photothermal therapy equipment; 15-rotating magnet device housing; 121 display; 122-emergency stop button; 123-pause button; 124-rotation direction button; 125-switch button; 126-rotation speed knob; 131-motor controller; 132-switching power supply. DETAILED DESCRIPTION

[0033] In order to enable those skilled in the art to better understand the technical solution of the present invention, the following examples further describe the technical solution of the present invention in detail. The following examples are only used to illustrate the present invention but are not used to limit the scope of the present invention.

[0034] Example 1: A magnetically controlled micro-nanoparticle device with positioning / treatment functions

[0035] See Figure 1-3 It includes a bracket 1, a rotating magnet device 2 arranged on the bracket 1, the rotating magnet device includes a rotating magnet 11, a rotating motor 9 and a rotating magnet device housing 15, a mobile platform 3 for controlling the bracket 1 to move in space, a positioning device 4 arranged on the rotating magnet device housing 15 and a manipulation device 10 for controlling the operation of the entire magnetically regulated micro-nanoparticle device.

[0036] The rotating magnet device 2 , the moving platform 3 , the positioning device 4 and the operating device 10 are electrically connected.

[0037] The positioning device 4 is composed of a laser positioning light-1 (51) and a laser positioning light-2 (52). The angle between the positions of the laser positioning light-1 (51) and the laser positioning light-2 (52) is 90 degrees, and the laser positioning light-1 (51) and the laser positioning light-2 (52) are respectively installed at a 45-degree inclination angle with the rotating magnet device housing 15. The two straight-line laser beams of the laser positioning light-1 (51) and the laser positioning light-2 (52) intersect, and the intersection point falls on the center position of the magnetic field formed by the rotating magnet 11 on the surface of the target object. By changing the position of the laser intersection point, the movement of the magnetically regulated nanoparticles is accurately assisted and guided.

[0038] A photothermal therapy laser device 14 is arranged on the rotating magnet device housing 15 for performing photothermal therapy on patients.

[0039] In this embodiment, the bracket 1 is a C-shaped bracket.

[0040] Rotating magnet devices 2 are respectively installed at both ends of the bracket 1. The rotating magnet device 2 includes a rotating motor 9 and a rotating magnet 11 arranged on the shaft of the rotating motor 9. The rotating magnet 11 is a permanent magnet.

[0041] The permanent magnet is placed in the rotating magnet device 2, and a positioning device 4 is provided on the surface of the rotating magnet device 2 for assisting in guiding the movement of the magnetically regulated nanoparticles.

[0042] A bracket sleeve 6 is provided on the mobile platform 3, and the bracket 1 passes through the bracket sleeve 6. A motor gear transmission device 7 is provided in the bracket sleeve 6. Correspondingly, an arc-shaped rack 8 matching the motor gear transmission device 7 is provided on the connection side between the bracket 1 and the motor gear transmission device 7. The bracket 1 rotates under the drive of the motor gear transmission device 7.

[0043] The mobile platform 3 may be a three-axis mobile platform, which can realize the movement of the bracket in three-dimensional space of X-axis, Y-axis and Z-axis.

[0044] The mobile platform 3 is controlled by a stepping motor.

[0045] The operating device 10 is composed of a control panel 12 and a control component group 13 .

[0046] The control panel 12 is composed of a control button group and a display 121 .

[0047] The control device group 13 is composed of a motor controller 131 and a switching power supply 132 .

[0048] In this embodiment, the control button group is provided with an emergency stop button 122 (when an emergency occurs, this button can be quickly pressed to achieve a protective measure), a pause button 123, a switch button 125, and a rotation direction button 124 and a rotation speed button 126 for controlling the rotating motor. The direction button 124 and the speed button 126 are used to control the rotating motor so as to control the direction and speed of the magnetic control device.

[0049] The display 121 displays information such as the real-time speed and rotation direction of the rotating motor.

[0050] Verification Example 1: Experiment on accelerated thrombolysis using magnetically regulated nanoparticles:

[0051] like Figure 4As shown, the magnetically regulated micro-nanoparticle device of Example 1 was used to conduct an accelerated thrombolysis experiment on rabbits. The rabbits were injected with magnetic thrombolytic drugs, and the drugs were guided to the embolic site by the magnetic field of the device. The rotation frequency (0-50Hz) of the rotating motor of the magnetically regulated micro-nanoparticle device was adjusted, and the positioning device laser positioning light-1 (51) and laser positioning light-2 (52) emitted two straight-line laser beams. The two laser beams intersected, and the intersection determined the regional position of the magnetic drug. As the magnetically regulated micro-nanoparticle device moved, the position of the laser intersection changed, and the position of the magnetic drug was always in the laser intersection area.

[0052] The preferred embodiments of the present invention are described in detail above. However, the present invention is not limited to the specific details in the above embodiments. Within the technical concept of the present invention, various changes can be made to the technical scheme of the present invention. These simple variations all belong to the protection scope of the present invention.

Claims

1. A magnetically regulated micro-nanoparticle device with positioning / treatment function, the device comprising a support (1), a rotating magnet device (2) arranged on the support (1), the rotating magnet device comprising a rotating magnet (11), a rotating motor (9) and a rotating magnet device housing (15), a mobile platform (3) for controlling the support (1) to move in space, a positioning device (4) arranged on the rotating magnet device housing (15), and a manipulation device (10) for controlling the operation of the entire magnetically regulated micro-nanoparticle device, wherein the positioning device (4) is arranged on the surface of the rotating magnet device housing (15), and is composed of two or more positioning devices with positioning function, wherein the intersection point of the light emitted by the positioning device falls on the center of the magnetic field formed by the rotating magnet (11) on the surface of the target object, and a laser device (14) for photothermal treatment is arranged on the rotating magnet device housing (15), and the positioning device is an infrared positioning device.

2. The magnetically controlled micro-nanoparticle device with positioning / treatment function as claimed in claim 1, wherein the angle between the positioners is 90 degrees, and the positioners are inclined at a 45 degree angle to the rotating magnet device housing (15).

3. The magnetically controlled micro-nanoparticle device with positioning / treatment function as claimed in claim 1, characterized in that: The bracket (1) can be a C-shaped bracket or a U-shaped bracket.

4. The magnetically controlled micro-nanoparticle device with positioning / treatment function as claimed in claim 1, characterized in that: The mobile platform (3) can be a three-axis mobile platform, which can realize the movement of the bracket in the three-dimensional space of the X-axis, Y-axis and Z-axis.

5. The magnetically controlled micro-nanoparticle device with positioning / treatment function as claimed in claim 1, characterized in that The magnetically regulated micro-nanoparticle device with positioning / treatment function can be handheld or fixed on other robotic arm devices.

6. The magnetically controlled micro-nanoparticle device with positioning / treatment function as claimed in claim 1, characterized in that The operating device (10) is composed of a control device group (13) and a control panel (12).

7. The magnetically controlled micro-nanoparticle device with positioning / treatment function as claimed in claim 1, characterized in that The control device group (13) is composed of a motor controller (111) and a switching power supply (112).

8. The magnetically controlled micro-nanoparticle device with positioning / treatment function as claimed in claim 1, characterized in that The control panel (12) is composed of a control button group and a display (121).

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