A metronidazole hydroxylation reaction device

Abstract

The invention relates to the technical field of metronidazole hydroxylation reaction devices, and specifically discloses a metronidazole hydroxylation reaction device, comprising a vacuum tank, wherein a supporting mechanism is arranged at the bottom of the vacuum tank, a reaction tank is embedded and installed inside the vacuum tank, a heating mechanism is arranged inside the vacuum tank and near the bottom of the reaction tank, a ring plate is fixedly connected to the upper inner side of the reaction tank, a ring tube is connected to the top of the ring plate through a clamping mechanism, a plurality of lower arc tubes are connected and installed inside the ring tube, and a plurality of lower arc tubes are connected and installed inside the plurality of groups of manifolds, a rotating shaft is rotatably installed at the bottom of the inner side of the reaction tank, spoiler mechanisms are arranged on the outer walls on both sides of the rotating shaft, a conveying mechanism is arranged on the inner side of the vacuum tank and the reaction tank, and a movable mechanism is arranged on the top of the vacuum tank. The invention can cooperate with the spoiler mechanism during material injection to promote a better stirring effect.

Description

Technical Field

[0001] The invention relates to the technical field of metronidazole hydroxylation reaction devices, and specifically discloses a metronidazole hydroxylation reaction device. Background Art

[0002] When producing metronidazole, a metronidazole hydroxylation reactor is needed. During the reaction, ethylene oxide needs to be continuously introduced into the reactor to ensure the normal progress of the reaction. When the ethylene oxide gas enters, it needs to be stirred inside the reactor. The existing device has poor stirring effect due to the gas state, so we need to improve it. Summary of the invention

[0003] The purpose of the present invention is to solve the shortcomings existing in the background technology and to propose a metronidazole hydroxylation reaction device.

[0004] To achieve the above purpose, the present invention provides a metronidazole hydroxylation reaction device, including a vacuum tank, a supporting mechanism is provided at the bottom of the vacuum tank, a reaction tank is embedded and installed inside the vacuum tank, a heating mechanism is provided inside the vacuum tank and near the bottom of the reaction tank, a ring plate is fixedly connected to the upper inner side of the reaction tank, a ring tube is connected to the top of the ring plate through a clamping mechanism, a plurality of lower arc tubes are connected and installed inside the ring tube, and a plurality of lower arc tubes are connected and installed inside, a rotating shaft is rotatably installed at the bottom of the inner side of the reaction tank, and spoiler mechanisms are provided on the outer walls on both sides of the rotating shaft, a conveying mechanism is provided on the inner side of the vacuum tank and the reaction tank, and a movable mechanism is provided on the top of the vacuum tank.

[0005] Preferably, the support mechanism comprises a plurality of groups of support frames, and the plurality of groups of support frames are installed at equal distances in a circular direction at the bottom of the vacuum tank.

[0006] Preferably, the heating mechanism includes a temperature control box connected and installed inside the vacuum tank, a heating pipe is connected and installed inside the temperature control box, one end of the heating pipe is installed at the bottom of the reaction tank, a connecting pipe is connected and installed inside one end of the heating pipe, and one end of the connecting pipe extends to the outside of the vacuum tank.

[0007] Preferably, the clamping mechanism comprises a plurality of sets of sleeves, the plurality of sets of sleeves are installed on the top of the ring plate at equal distances in a circular direction, and the ring tubes are clamped together inside the plurality of sets of sleeves.

[0008] Preferably, the spoiler mechanism includes an L-shaped frame fixedly installed on one side of the rotating shaft, connecting seats are symmetrically installed on both sides of the outer wall of the L-shaped frame, fixing rods are commonly inserted into the inner sides of two groups of connecting seats close to each other, and spoilers are fixedly connected to the outer sides of the fixing rods. A driving mechanism is provided at the top of the rotating shaft, U-shaped frames are installed on both sides of the bottom of the L-shaped frame, reinforcement seats are fixedly connected to the outer sides of the two groups of U-shaped frames, and scrapers are clamped on the inner sides of the two reinforcement seats.

[0009] Preferably, the driving mechanism comprises a gear box installed at the top end of the rotating shaft, one end of the gear box is connected to a motor, and the bottom of the motor is connected to the vacuum tank via an installed fixing frame.

[0010] Preferably, the conveying mechanism includes a square tube that connects the inside of the vacuum tank and one side of the reaction tank in sequence, one end of the square tube is connected to the ring tube, and the other end of the square tube is connected to a connecting pipe. A conveying pump is installed on the upper inner side of the connecting pipe, and the end of the conveying pump away from the connecting pipe is connected to a storage tank.

[0011] Preferably, the movable mechanism includes a sealing cover fixedly installed on the top of the vacuum tank, a flap is rotatably installed on one end of the sealing cover, an arc frame is fixedly connected to the outer wall of one side of the vacuum tank, an arc plate is fixedly connected to the top of the arc frame, and an exhaust valve is installed at the lower position inside one end of the vacuum tank.

[0012] Compared with the prior art, the present invention has the following beneficial effects:

[0013] The heating mechanism can control the temperature of the heating tube through the temperature control box, so that the temperature of the heating tube is controlled within the heating range, thereby ensuring a better reaction effect of the materials inside the reaction tank.

[0014] By setting the ring pipe, lower arc pipe and multi-component flow pipe in connection with the conveying mechanism, the ethylene oxide injected from the outside is evenly distributed in the middle and lower positions inside the reaction tank, so that when the gaseous ethylene oxide is injected, it is more fully mixed with other raw materials.

[0015] The spoiler mechanism can be combined with the spreading tracks of the lower arc tube and the multi-component manifold to fully spoil the material inside the reaction tank in the middle and below the inner side of the reaction tank to ensure better stirring effect. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 It is a structural schematic diagram of the present invention;

[0017] Figure 2 It is a structural schematic diagram of another viewing angle of the present invention;

[0018] Figure 3 This is a cross-sectional view of the connection between the vacuum tank and the heating mechanism of the present invention;

[0019] Figure 4 This is a cross-sectional view of the internal structure of the reaction tank of the present invention;

[0020] Figure 5 It is a schematic diagram of the connection between the heating mechanism and the ring tube of the present invention;

[0021] Figure 6 It is a schematic diagram of the connection between the rotating shaft and the L-shaped frame of the present invention;

[0022] Figure 7 It is a schematic diagram of the connection between the scraper and the rotating shaft of the present invention.

[0023] In the figure: 1. support frame; 2. vacuum tank; 3. temperature control box; 4. sealing cover; 5. arc frame; 6. arc plate; 7. gear box; 8. motor; 9. flap; 10. exhaust valve; 11. storage tank; 12. fixed frame; 13. reaction tank; 14. heating tube; 15. delivery pump; 16. square tube; 17. rotating shaft; 18. L-shaped frame; 19. scraper; 20. spoiler; 21. ring pipe; 22. lower arc pipe; 23. sleeve frame; 24. shunt pipe; 25. ring plate; 26. fixing rod; 27. connecting seat; 28. U-shaped frame; 29. ​​reinforcement seat; 30. connecting pipe. DETAILED DESCRIPTION

[0024] In order to more clearly understand the above-mentioned objects, features and advantages of the present invention, the present invention is further described in detail below with reference to the accompanying drawings and specific embodiments.

[0025] like Figure 1-Figure 7 A metronidazole hydroxylation reaction device is shown, comprising a vacuum tank 2, a supporting mechanism is arranged at the bottom of the vacuum tank 2, a reaction tank 13 is embedded and installed inside the vacuum tank 2, a heating mechanism is arranged inside the vacuum tank 2 and near the bottom of the reaction tank 13, a ring plate 25 is fixedly connected to the upper inner side of the reaction tank 13, a ring plate 25 is connected to the top of the ring plate 25 through a clamping mechanism, a plurality of lower arc tubes 22 are connected and installed inside the ring tube 21, and a plurality of groups of manifolds 24 are connected and installed inside the plurality of lower arc tubes 22, a rotating shaft 17 is rotatably installed at the bottom of the inner side of the reaction tank 13, and a spoiler mechanism is arranged on the outer walls on both sides of the rotating shaft 17, a conveying mechanism is arranged on the inner side of the vacuum tank 2 and the reaction tank 13, and a movable mechanism is arranged on the top of the vacuum tank 2.

[0026] The annular tube 21 can enable the multiple lower arc tubes 22 to uniformly inject ethylene oxide through the multi-component flow tubes 24 in the middle and below of the inner side of the reaction tank 13 .

[0027] The supporting mechanism comprises a plurality of supporting frames 1 , which are installed at the bottom of the vacuum tank 2 at equal distances in a circular direction.

[0028] Multiple sets of support frames 1 can stably support the use of vacuum tank 2 and reaction tank 13

[0029] The heating mechanism includes a temperature control box 3 connected and installed inside the vacuum tank 2, a heating pipe 14 is connected and installed inside the temperature control box 3, one end of the heating pipe 14 is installed at the bottom of the reaction tank 13, and a connecting pipe 30 is connected and installed inside one end of the heating pipe 14, and one end of the connecting pipe 30 extends to the outside of the vacuum tank 2.

[0030] The connection pipe 30 can be connected to an external connection element to ensure the use of the heating pipe 14. Under the control of the temperature control box 3, the heating temperature can be adjusted.

[0031] The clamping mechanism comprises a plurality of sets of sleeve frames 23 , which are mounted on the top of the ring plate 25 at equal distances in a circular direction, and the ring tubes 21 are clamped together inside the plurality of sets of sleeve frames 23 .

[0032] The installation of multiple sets of brackets 23 can enable the annular tube 21 to be stably mounted above the annular plate 25 .

[0033] The spoiler mechanism includes an L-shaped frame 18 fixedly installed on one side of the rotating shaft 17, and connecting seats 27 are symmetrically installed on both sides of the outer wall of the L-shaped frame 18. A fixing rod 26 is inserted into the inner side of two groups of connecting seats 27 close to each other, and a spoiler 20 is fixedly connected to the outer side of the fixing rod 26. A driving mechanism is provided at the top of the rotating shaft 17, and U-shaped frames 28 are installed on both sides of the bottom of the L-shaped frame 18. Reinforcement seats 29 are fixedly connected to the outer sides of the two groups of U-shaped frames 28, and scrapers 19 are clamped on the inner sides of the two reinforcement seats 29.

[0034] The L-shaped frame 18 can be coordinated with the two sets of connecting seats 27 at the corresponding positions, and the auxiliary spoiler 20 can disturb the ethylene oxide ejected from the shunt pipe 24 below one end of the shunt pipe 24, so as to ensure that the ethylene oxide can evenly shuttle inside the material during the disturbance, so as to achieve the purpose of uniform stirring. The installed reinforcement seat 29 can drive the scraper 19 to turn over the material at the bottom of the inner side of the reaction tank 13 as the rotating shaft 17 rotates, so as to ensure that the material at the bottom can be more fully in contact with the ethylene oxide, and at the same time, the later discharge is more thorough.

[0035] The driving mechanism comprises a gear box 7 mounted on the top of the rotating shaft 17 , one end of the gear box 7 is connected to a motor 8 , and the bottom of the motor 8 is connected to the vacuum tank 2 via a fixed frame 12 .

[0036] After the motor 8 is connected to a power source, the gear box 7 that cooperates with each other can be driven to rotate, so that the rotating shaft 17 that cooperates with the inside of the gear box 7 can rotate inside the reaction tank 13.

[0037] The conveying mechanism includes a square tube 16 which connects the inside of the vacuum tank 2 and one side of the reaction tank 13 in sequence. One end of the square tube 16 is connected to the ring tube 21, and the other end of the square tube 16 is connected to a connecting pipe. A conveying pump 15 is installed on the upper inner side of the connecting pipe, and the end of the conveying pump 15 away from the connecting pipe is connected to the storage tank 11.

[0038] The square tube 16 and the connecting tube can facilitate the delivery pump 15 to suck the ethylene oxide gas inside the storage tank 11, and then deliver it to the inside of the ring tube 21 for use.

[0039] The movable mechanism includes a sealing cover 4 fixedly installed on the top of the vacuum tank 2, a flap 9 is rotatably installed on one end of the sealing cover 4, an arc frame 5 is fixedly connected to the outer wall of one side of the vacuum tank 2, an arc plate 6 is fixedly connected to the top of the arc frame 5, and an exhaust valve 10 is installed at the lower position inside one end of the vacuum tank 2.

[0040] The flap 9 can play the role of opening and closing at one end, which is convenient for injecting materials above the vacuum tank 2. The arc frame 5 supports the use of the arc plate 6 above the vacuum tank 2, and the arc plate 6 plays the role of assisting in discharging materials. The exhaust valve 10 arranged below one end of the vacuum tank 2 can properly discharge excess pressurized gas from the inside of one end of the vacuum tank 2.

[0041] Working principle: When in use, the material is poured from the top of the vacuum tank 2, and then the ethylene oxide inside the storage tank 11 is sucked to the square tube 16 connected at one end through the connection of the delivery pump 15, and then input into the ring tube 21 inside the reaction tank 13 through the square tube 16. The ring tube 21 evenly distributes the ethylene oxide inside through each group of lower arc tubes 22 to the middle and lower positions inside the reaction tank 13. In this way, when the gaseous ethylene oxide is injected, it can be better mixed with the material inside the tube and flow evenly inside the material. At this time, the heating tube 1 at the bottom of the reaction tank 13 is heated through the connecting tube 30. 4. Under the control of the temperature control box 3, the temperature is controlled within the heating range of ethylene oxide to improve the reaction rate. Then the motor 8 is powered on at the top to drive the gear box 7 at the input end to rotate, causing the gear box 7 and the matching rotating shaft 17 to rotate. The rotation of the rotating shaft 17 causes the L-shaped frames 18 installed on both sides and the spoiler 20 on the outside to rotate at the position where the multi-component manifold 24 sprays gas, so that the material inside the reaction tank 13 is fully in contact with ethylene oxide, effectively ensuring stirring. In this process, the stirring rate between ethylene oxide and the material is further improved through the effects of injection and turbulence, thereby improving the reaction efficiency.

[0042] In the description of this specification, if the terms "one embodiment", "some embodiments", "specific embodiments" and the like appear, it means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representations of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described may be combined in any one or more embodiments or examples in a suitable manner.

Claims

1. A metronidazole hydroxylation reaction device, comprising a vacuum tank (2), characterized in that: A supporting mechanism is provided at the bottom of the vacuum tank (2); a reaction tank (13) is embedded and installed inside the vacuum tank (2); a heating mechanism is provided inside the vacuum tank (2) and close to the bottom of the reaction tank (13); a ring plate (25) is fixedly connected to the top of the inside of the reaction tank (13); a ring tube (21) is connected to the top of the ring plate (25) via a clamping mechanism; a plurality of lower arc tubes (22) are connected and installed inside the ring tube (21); and a plurality of groups of manifolds (24) are connected and installed inside the plurality of lower arc tubes (22). A rotating shaft (17) is rotatably mounted at the bottom of the inner side of the reaction tank (13), and the outer walls on both sides of the rotating shaft (17) are provided with flow-turbulating mechanisms. The vacuum tank (2) and the reaction tank (13) are provided with a conveying mechanism, and the conveying mechanism comprises a square tube (16) arranged on one side of the vacuum tank (2) and the reaction tank (13), one end of the square tube (16) is connected to the ring tube (21), and the other end of the square tube (16) is connected to a connecting pipe, and a conveying pump (15) is installed on the upper side of the inner side of the connecting pipe, and the conveying pump (15) is far away from the connecting pipe. One end of the through pipe is connected to a storage tank (11), a movable mechanism is arranged on the top of the vacuum tank (2), the movable mechanism comprises a sealing cover (4) fixedly mounted on the top of the vacuum tank (2), a flap (9) is rotatably mounted on one end of the sealing cover (4), an arc frame (5) is fixedly connected to the outer wall of one side of the vacuum tank (2), an arc plate (6) is fixedly connected to the top of the arc frame (5), an exhaust valve (10) is connected to the lower position of the interior of one end of the vacuum tank (2), and the spoiler mechanism comprises a plurality of flaps (9) fixedly mounted on both sides of the rotating shaft (17) An L-shaped frame (18) is provided, wherein connecting seats (27) are symmetrically mounted on the outer wall of the L-shaped frame (18), fixing rods (26) are commonly inserted into the inner sides of two groups of the connecting seats (27) close to each other, and spoilers (20) are fixedly connected to the outer sides of the fixing rods (26), a driving mechanism is arranged at the top end of the rotating shaft (17), a U-shaped frame (28) is mounted on the bottom of each L-shaped frame (18), and reinforcement seats (29) are fixedly connected to the outer sides of the two groups of the U-shaped frames (28), and scrapers (19) are clamped on the inner sides of the two reinforcement seats (29).

2. A metronidazole hydroxylation reaction device according to claim 1, characterized in that: The support mechanism comprises a plurality of groups of support frames (1), wherein the plurality of groups of support frames (1) are installed at equal distances in a circular direction at the bottom of the vacuum tank (2).

3. A metronidazole hydroxylation reaction device according to claim 1, characterized in that: The heating mechanism comprises a temperature control box (3) which is connected and mounted on the vacuum tank (2); a heating pipe (14) is connected and mounted inside the temperature control box (3); one end of the heating pipe (14) is mounted on the bottom of the reaction tank (13); a connecting pipe (30) is connected and mounted inside one end of the heating pipe (14); one end of the connecting pipe (30) extends to the outside of the vacuum tank (2).

4. A metronidazole hydroxylation reaction device according to claim 1, characterized in that: The clamping mechanism comprises a plurality of sets of sleeve frames (23), the plurality of sets of sleeve frames (23) being mounted on the top of the ring plate (25) at equal distances in a circular direction, and the ring tube (21) being clamped together inside the plurality of sets of sleeve frames (23).

5. A metronidazole hydroxylation reaction device according to claim 1, characterized in that: The driving mechanism comprises a gear box (7) mounted on the top of a rotating shaft (17), one end of the gear box (7) is connected to a motor (8), and the bottom of the motor (8) is connected to the vacuum tank (2) via a mounted fixing frame (12).

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