Electrolyte analysis device

Abstract

An electrolyte analysis device includes a plurality of analysis cells (50) each having an ISE electrode (1) for measuring a concentration of an electrolyte of a sample, and a control device (29) for controlling operations in the electrolyte analysis device (100) including the analysis cells (50). The ISE electrodes (1) of the plurality of analysis cells (50) analyze the same analysis item. The control device (29) selects, from the plurality of analysis cells (50), an analysis cell (50) to be used for measurement in accordance with a remaining number of measurements and a measurement request state of each of the plurality of ISE electrodes (1). Thus, an electrolyte analysis device is provided which can appropriately perform replacement of consumables while exerting analysis processing capacity compared to the past.

Description

TECHNICAL FIELD

[0001] The present application relates to an electrolyte analysis device. BACKGROUND

[0002] As an example of an electrolyte measuring device which does not complicate the structure of the device as a whole, and which can correctly perform the measurement without depending on the concentration of a sample solution, in addition to the sample solution, Patent Literature 1 describes a device provided with: a measuring section which measures the electromotive force of each of a standard solution and a sample solution using an electrode section; a dilution tank which generates a sample solution by diluting a sample liquid with a dilution liquid; a sample supply unit which supplies the sample liquid to the dilution tank; a dilution liquid supply unit which supplies the dilution liquid to the dilution tank; a standard solution supply unit which supplies the standard solution to the dilution tank; a measuring solution supply unit which supplies the standard solution and the sample solution from the dilution tank to the electrode section; and a control section which controls so that the standard solution and the sample solution are alternately supplied from the dilution tank to the electrode section, and which controls so that a given amount of the dilution liquid is supplied to the dilution tank and discharged before the sample solution is generated.

[0003] PRIOR ART DOCUMENTS

[0004] PATENT LITERATURE

[0005] Patent Literature 1: JP Patent Publication No. 2012-189405 SUMMARY

[0006] PROBLEMS TO BE SOLVED BY THE INVENTION

[0007] The electrolyte analysis device described in the above Patent Literature 1 is a device which measures the concentration of a specific electrolyte (sodium (Na), potassium (K), chlorine (Cl), etc.) contained in an electrolyte solution such as blood, urine, etc. of a human body, and concentration measurement is performed using an ion-selective electrode.

[0008] As a general method of measuring the concentration of an electrolyte, a flow-type measuring method is mainly used, in which a sample solution which is serum as an electrolyte solution or which is diluted by a dilution liquid is supplied to an ion-selective electrode, and the inter-liquid potential of a reference electrode liquid is measured and compared. Next, either before the above measurement, or after the above measurement, a standard solution is supplied to the ion-selective electrode, and the inter-liquid potential of the reference electrode liquid is similarly measured and compared, and the concentration of the electrolyte of the sample solution is calculated from the two inter-liquid potential levels.

[0009] In a flow-type electrolyte analysis device, in addition to reagents such as a dilution liquid, a standard solution, a reference electrode liquid, an ion-selective electrode is also used as a consumable, and the replacement work of these consumables is performed by a user.

[0010] According to existing electrolyte analysis devices, although the number of measurements and the service life are specified for consumables such as electrodes and reagents, except for reagents, there is almost no management of the number of measurements and the service life.

[0011] Furthermore, in electrolyte analysis apparatuses equipped with analytical cells, it is extremely rare for the residual energy measurement count to be consistent across analytical cells; discrepancies are more common. Despite this situation, the analytical cells used are often simply alternated or always measured from one particular analytical cell, without proper allocation.

[0012] Therefore, through the discussions of the inventors of this invention, it has been clarified that situations may arise where the frequency of user replacement of consumables increases beyond what is necessary, and the maximum processing capacity can no longer be achieved.

[0013] The present invention addresses this problem by providing an electrolyte analysis apparatus that, compared to the past, allows for the appropriate replacement of consumables while maintaining analytical processing capabilities.

[0014] Methods for solving problems

[0015] The present invention includes various means to solve the above-mentioned problems. One example is an electrolyte analysis apparatus for analyzing the electrolyte concentration of a sample, comprising: a plurality of analytical cells having consumables for measuring the electrolyte concentration of the sample; and a control unit for controlling the operation within the electrolyte analysis apparatus including the analytical cells. The plurality of analytical cells share a dispensing mechanism for dispensing the sample into the analytical cells. The consumables of the plurality of analytical cells analyze the same analytical item. The control unit selects the analytical cell to be used in the measurement from the plurality of analytical cells according to the remaining energy measurement count and measurement request status of each of the plurality of consumables. Furthermore, when the plurality of dispensing mechanisms are provided, the dispensing mechanism used in the dispensing and the analytical cell used in the measurement are selected according to the remaining energy measurement count and measurement request status of each of the plurality of analytical cells.

[0016] The effects of the invention

[0017] According to the present invention, compared with the past, consumables can be replaced appropriately while exerting analytical processing capabilities. Other issues, structures, and effects beyond those described above will become clear through the following description of embodiments. Attached Figure Description

[0018] Figure 1 This is a diagram showing the overall structure of the electrolyte analysis device according to Embodiment 1 of the present invention.

[0019] Figure 2 This is a diagram showing the schematic structure of the analysis tank in the electrolyte analysis apparatus of Example 1.

[0020] Figure 3 This is the process for judging the status and processing capacity of the electrolyte analysis device in Example 1.

[0021] Figure 4 This is a diagram showing the display of the remaining energy measurement data of the electrolyte analysis device in Example 1.

[0022] Figure 5 This is another example of the process for determining the status and processing capacity of the electrolyte analysis device in Example 1.

[0023] Figure 6 This is a diagram showing the selection of the preferred analytical cell displayed on the display device of the electrolyte analysis apparatus in Example 1.

[0024] Figure 7 This is a diagram showing the selection of the preferred analytical cell displayed on the display device of the electrolyte analysis apparatus in Example 1.

[0025] Figure 8 This is a diagram showing the overall structure of the electrolyte analysis device according to Embodiment 2 of the present invention.

[0026] Figure 9 This is a diagram showing the selection of the preferred dispensing mechanism displayed on the display device of the electrolyte analysis apparatus in Example 2.

[0027] Figure 10 This is a diagram showing the selection of the preferred analytical cell displayed on the display device of the electrolyte analysis apparatus in Example 2. Detailed Implementation

[0028] The following description uses accompanying drawings to illustrate embodiments of the electrolyte analysis apparatus of the present invention. Furthermore, in the drawings used in this specification, the same or corresponding components are labeled with the same or similar reference numerals, and repeated descriptions of these components are sometimes omitted.

[0029] Furthermore, in the embodiments shown below, the electrolyte analysis device is described as consisting of one or more devices for analyzing electrolyte items. However, the device structure is not limited to these methods and can be configured as a device mounted on an automated analysis device. Examples of automated analysis devices include automated biochemical analysis devices and automated immunoassay devices. Alternatively, it can be configured as a quality analysis device used in clinical examinations, a coagulation analysis device for measuring blood clotting time, or a composite system of these with automated biochemical analysis devices or automated immunoassay devices, and thus mounted on an automated analysis system that utilizes these.

[0030] <Example 1>

[0031] use Figures 1 to 7 The electrolyte analysis device of Embodiment 1 of the present invention will be described below.

[0032] initially used Figure 1 as well as Figure 2 This will explain the overall structure and the structure of the main parts of the electrolyte analysis device. Figure 1 This is a diagram showing the overall structure of the electrolyte analysis device in Embodiment 1. Figure 2 This is a diagram showing the general structure of the analytical cell in an electrolyte analysis apparatus.

[0033] Figure 2 The electrolyte analysis device 100 shown includes a transport line 71, a clamp 55, a dispensing line 65, 66, a pre-analysis buffer 61, a post-analysis buffer 62, two analysis tanks 50, a sample probe 14, a display device 80, and a control device 29.

[0034] The transport line 71 is a device that is located at the end of the device and transports a transport container 90, which is inserted from the sample holder insertion part (not shown) and carries multiple sample containers 15 containing samples, to the transfer position of the clamp 55, and transports the transport container 90 after the measurement is completed.

[0035] Furthermore, this embodiment describes an example where the transport container 90 carries multiple sample containers 15, but the transport container 90 only needs to carry one or more sample containers 15. Other examples of the transport container 90 include a sample holder that can carry one sample container 15.

[0036] The gripper 55 is a mechanism for transferring the transport container 90 from the transport line 71 to the dispensing lines 65, 66, or from the dispensing lines 65, 66 to the transport line 71.

[0037] Separation lines 65 and 66 are mechanisms for transporting sample containers 15 containing the separated objects in transport container 90 to the separation position of sample probe 14, or for transport container 90 containing the separated sample containers 15 to the post-analysis buffer 62.

[0038] The pre-analysis buffer 61 and post-analysis buffer 62 are spaces where the sample container 15 waiting to be dispensed into the analysis slot 50 and the sample container 15 after the analysis is completed are kept in standby mode before being transported to other parts.

[0039] The analytical cell 50 is an analytical section with an ISE electrode 1 for measuring the electrolyte concentration of a sample. Two electrodes are provided, sharing a sample probe 14 for dispensing the sample into the analytical cell 50. Figure 2 To explain the details. In addition, the number of analysis cells 50 provided in the electrolyte analysis device 100 can be 2 or more, and can be 3 or more.

[0040] Figure 2 The analytical cell 50 shown is a flow-type analytical cell that uses an ion-selective electrode (hereinafter referred to as an ISE electrode).

[0041] exist Figure 2 In the main components of the analytical cell 50, five components are shown: sample dispensing section, ISE electrode section, reagent section, mechanism section, and waste liquid mechanism, as well as control device 29. The control device 29 controls these components and performs calculations and displays the electrolyte concentration based on the measurement results.

[0042] The sample dispensing unit includes a sample probe 14. The sample probe 14 dispenses patient samples and other samples held in the sample container 15 into the analytical apparatus. Here, "sample" refers to any analytical object collected from a patient's biological body, such as blood or urine. These analytical objects that have undergone given pretreatment are also referred to as samples.

[0043] The ISE electrode section includes a dilution tank 11, a suction nozzle 13, a diluent nozzle 24, an internal standard solution nozzle 25, an ISE electrode 1, a comparator electrode 2, a clamp valve 23, a voltmeter 27, and an amplifier 28. The sample dispensed from the sample dispensing unit is sprayed into the dilution tank 11, and diluted / stirred with diluent sprayed from the diluent nozzle 24 into the dilution tank 11. The suction nozzle 13 is connected to the ISE electrode 1 via a flow path, through which the diluted sample solution drawn from the dilution tank 11 is delivered to the ISE electrode 1. Conversely, by actuating the suction syringe 10 with the clamp valve 23 closed, the comparator electrode solution contained in the comparator electrode solution bottle 5 is delivered to the comparator electrode 2. The ISE electrode 1 and the comparator electrode 2 are electrically connected through contact between the diluted sample solution delivered to the ISE electrode flow path and the comparator electrode solution delivered to the comparator electrode flow path. The ISE electrode section measures the concentration of a specific electrolyte contained in the sample by the potential difference between the ISE electrode 1 and the comparator electrode 2.

[0044] Specifically, an ISE electrode 1 is attached with ions corresponding to specific ions in the sample solution (e.g., sodium ions (Na+)). + ), potassium ions (K) + ), chloride ions (Cl) - An ion-sensing membrane with a property that changes its electromotive force (EMF) based on the concentration of ions in the sample solution is used. The ISE electrode 1 outputs an EMF corresponding to the concentration of each ion in the sample solution. The EMF between the ISE electrode 1 and the comparison electrode 2 is obtained by a voltmeter 27 and an amplifier 28. In the control device 29, the concentration of each ion in the sample is calculated based on the obtained EMF and displayed. The remaining sample solution in the dilution tank 11 is discharged through a waste liquid mechanism.

[0045] In this invention, the ISE electrode 1 is provided with an identification medium 1A for individual identification, and the ISE electrode section includes a reading device 1B for reading individual identification information recorded in the identification medium 1A. The identification information read by the reading device 1B is sent to the control device 29.

[0046] In this embodiment, the ISE electrodes 1 of the two analysis tanks 50 analyze the same analytical items and are of the same specification.

[0047] Furthermore, the potential difference between the ISE electrode 1 and the comparator electrode 2 is easily affected by temperature changes, etc. To correct for potential fluctuations caused by such temperature changes, it is preferable to spray internal standard solution into the dilution tank 11 through the internal standard solution nozzle 25 during the period between one sample measurement and the next sample measurement, and perform the measurement in the same manner as for the samples described above. It is preferable to use the results of the internal standard solution measurement performed between sample measurements to correct for the fluctuations. In this case, dilution of the internal standard solution is not performed.

[0048] The reagent section includes a suction nozzle 6 for drawing reagents from the reagent container, a degassing mechanism 7, and a filter 16, supplying the reagents required for the measurement. In the case of electrolyte measurement, three reagents are used as reagents: an internal standard solution, a diluent, and a comparison electrode solution. The reagent section contains an internal standard solution bottle 3 containing the internal standard solution, a diluent bottle 4 containing the diluent, and a comparison electrode solution bottle 5 containing the comparison electrode solution. Figure 2 This state is shown. Furthermore, when cleaning the apparatus, a bottle containing the cleaning solution is placed in the reagent section.

[0049] The internal standard solution bottle 3 and the diluent bottle 4 are connected to the internal standard solution nozzle 25 and the diluent nozzle 24 respectively via a filter 16 and a flow path. Each nozzle is shaped to guide its tip into the dilution tank 11. Furthermore, the comparison electrode solution bottle 5 is connected to the comparison electrode 2 via a filter 16 and a flow path. Degassing mechanisms 7 are connected to the flow paths between the diluent bottle 4 and the dilution tank 11, and between the comparison electrode solution bottle 5 and the comparison electrode 2, respectively, supplying degassed reagents to the dilution tank 11 and the comparison electrode 2. This is because the reagent is drawn up from the bottle by creating negative pressure in the flow path using a syringe; therefore, the dissolved gas in the reagent manifests as bubbles within the reagent. The degassing mechanisms are provided to ensure that the reagent is supplied to the dilution tank 11 and the comparison electrode 2 without maintaining a state where bubbles are present.

[0050] Furthermore, in this invention, the method of receiving reagents from dedicated internal standard solution bottle 3, diluent bottle 4 and comparison electrode solution bottle 5 for the two analytical tanks 50 is described, but it can also be configured to share one bottle.

[0051] The mechanism includes an internal standard solution injector 8, a diluent injector 9, a suction injector 10, solenoid valves 17, 18, 19, 20, 21, 22, and 30, and a preheater 12, and is responsible for liquid delivery within or between the mechanisms. For example, the internal standard solution and diluent are delivered to the dilution tank 11 by the operation of the internal standard solution injector 8 and the diluent injector 9, respectively, and the solenoid valves located in the flow path. The preheater 12 controls the temperature of the internal standard solution and diluent arriving at the ISE electrode 1 within a certain range to suppress the influence of temperature on the ISE electrode 1.

[0052] The waste liquid mechanism includes a first waste liquid nozzle 26, a second waste liquid nozzle 36, a vacuum bottle 34, a waste liquid collector 35, a vacuum pump 33, and solenoid valves 31 and 32, which discharge the sample solution remaining in the dilution tank 11 and the reaction liquid remaining in the flow path of the ISE electrode.

[0053] Back Figure 1 The display device 80 is a component that displays various screens, such as operation screens for measuring the sample to be measured and screens for confirming the measurement results, and is composed of an LCD or similar device. Specifically, the display... Figure 4 The remaining energy measurement management screen 501 and the analysis tank selection screens 600 and 700 are shown below. Details will be described later.

[0054] In addition, it does not need to be an LCD screen; it can be replaced with a printer or the like. It consists of a screen and a printer, and can also be set up as a touch panel type screen for inputting various parameters, settings, measurement results, measurement commission information, analysis start and stop instructions, etc., based on the displayed operation screen.

[0055] The control device 29 is connected to the analysis tank 50 or the like via a wired or wireless network line to control the operation within the electrolyte analysis apparatus 100, which includes the analysis tank 50. Furthermore, the control device 29 calculates the electrolyte concentration in the sample using the potential of the ISE electrode 1 measured against the sample solution. At this point, by correcting based on the ISE electrode potential measured against the internal standard solution, a more accurate determination of the electrolyte concentration can be achieved.

[0056] The control device 29 can be configured as a computer with a CPU (Central Processing Unit), RAM (Random Access Memory), storage devices, and I / O ports. The RAM, storage devices, and I / O ports are configured to exchange data with the CPU via an internal bus. The I / O ports are connected to the aforementioned mechanisms to control their operation. Operation control is achieved by reading the program stored in the storage device into the RAM and executing it with the CPU. Furthermore, by connecting input / output devices to the control device 29, user input and display of measurement results can be performed.

[0057] Next, the explanation Figure 2 The electrolyte concentration measuring device shown is used to measure electrolyte concentration. The measuring action is controlled by control device 29.

[0058] First, the sample dispensed from the sample container 15 via the sample probe 14 of the sample dispensing section is ejected into the dilution tank 11 of the ISE electrode section. After the sample is dispensed into the dilution tank 11, diluent is ejected from the diluent bottle 4 through the diluent nozzle 24 by the action of the diluent syringe 9 to dilute the sample. As described above, in order to prevent the generation of bubbles due to temperature and pressure changes of the diluent in the flow path, degassing is performed by a degassing mechanism 7 installed in the middle of the diluent flow path. The diluted sample solution is drawn towards the ISE electrode 1 by the action of the aspiration syringe 10 and the solenoid valve 22.

[0059] On the other hand, the comparison electrode solution is delivered from the comparison electrode solution bottle 5 to the comparison electrode 2 via the clamp valve 23 and the aspiration syringe 10. The comparison electrode solution is, for example, an aqueous solution of potassium chloride (KCl) of a given concentration. By connecting the sample solution and the comparison electrode solution, the ISE electrode 1 and the comparison electrode 2 are electrically connected. Furthermore, the electrolyte concentration of the comparison electrode solution is ideally high to suppress the effects of concentration fluctuations during sample delivery; however, since crystallization near the saturation concentration could potentially cause flow path blockage, a concentration between 0.5 mmol / L and 3.0 mmol / L is desirable. The ISE electrode potential, referenced to the comparison electrode potential, is measured using a voltmeter 27 and an amplifier 28.

[0060] In addition, before and after the sample determination, the internal standard solution placed in the internal standard solution bottle 3 of the reagent section is sprayed into the dilution tank 11 through the internal standard solution syringe 8, and the electrolyte concentration of the internal standard solution is determined in the same way as the sample determination.

[0061] Next, use Figures 3 to 7 This section describes the details of the control and process used for the allocation and analysis of the multiple analysis slots 50 of the present invention. Figure 3 as well as Figure 5It is a process for assessing the status of the entrustment and the processing capacity. Figure 4 This is a diagram showing the remaining energy measurement data displayed on the display device. Figure 6 as well as Figure 7 This is a diagram showing the screen displaying the selection priority of the analysis panel on the display device.

[0062] In this embodiment, when the analysis of a sample is instructed from the input section of the control device 29 or the operation screen of the display device 80, the control device 29 selects the analytical cell 50 on the side to be used for measurement from the two analytical cells 50 according to the remaining energy measurement count and measurement request status of the ISE electrodes 1 of each of the two analytical cells 50.

[0063] For example, if it is determined that the number of measurement requests processed by the electrolyte analyzer 100 within a given time is insufficient to meet its maximum processing capacity, allocation is performed to prioritize the use of the analyzer 50 with the highest remaining energy measurement capacity. In this case, allocation can be performed using the effective lifespan of the ISE electrode 1 in addition to the remaining energy measurement capacity, or alternatively, using the effective lifespan of the ISE electrode 1 instead of the remaining energy measurement capacity. Furthermore, in this situation, the following will be described... Figure 6 Step S203 is replaced by the step of “determining whether the effective service life of the ISE electrode 1 of the analytical cell 50 with more remaining energy measurements is longer than that of the other analytical cells 50”.

[0064] In this embodiment, the control device 29 intends to manage the remaining energy measurement based on the individual identification information read by the reading device 1B.

[0065] refer to Figure 3 This will explain the process of making such a judgment.

[0066] First, when an analysis request is received, the control device 29 determines whether maximum processing is required (step S101). If it is determined that it is required, the processing proceeds to step S102, so that analysis is performed in all analysis cells 50 (step S102). Conversely, if it is determined that it is not required, the processing proceeds to step S103, prioritizing the use of the analysis cells 50 with the most remaining measurable data (step S103).

[0067] More specifically, the maximum processing capacity of each analysis tank 50 is set to 300 samples / hour, or 5 samples / minute. Under these conditions, if the number of samples to be processed in 2 minutes exceeds 20, or 5 samples / (minute × tank) × 2 tanks × 2 minutes, the data is allocated so that both analysis tanks 50 process at their maximum capacity.

[0068] Furthermore, when 15 samples should be processed in 2 minutes and one analytical cell 50 has a smaller remaining energy capacity, an 8:7 allocation is performed without any control. In contrast, in this embodiment, the analytical cell 50 with a larger remaining energy capacity performs maximum processing (10 corresponding quantities), while the analytical cell 50 with a smaller remaining energy capacity analyzes only 5 corresponding quantities. Additionally, when the remaining energy capacity is approximately equal, the allocation is performed equally.

[0069] Furthermore, in the case of a single analysis request and a low number of remaining energy measurements in one of the analysis tanks 50, all analysis operations are performed only in the analysis tank 50 on the side with a high number of remaining energy measurements.

[0070] Expectation Figure 4 The remaining energy measurement management screen 501 shown is displayed on the display device 80 so that when such control is performed, the user can grasp the remaining energy measurement status of each analysis cell 50.

[0071] Figure 4 The remaining energy measurement count management screen 501 shown is a screen displayed on the display device 80, displaying the following: a tank display area 503 showing the type of analytical tank 50; a type display area 504 showing the type of each ion sensing membrane in the ISE electrode 1; a remaining measurement count display area 505 showing the remaining measurement count for each ion sensing membrane; an expiration date display area 506 showing the expiration date for each ion sensing membrane; and a close button 508 indicating when the remaining energy measurement count management screen 501 is closed. Based on this screen, the user can easily understand the current status of each analytical tank 50.

[0072] Furthermore, in this embodiment, the control device 29 intends to select the analytical cell 50 to be used in the measurement based not only on the remaining energy measurement number but also on the remaining liquid volume of the reagent used in the analytical cell 50.

[0073] For example, an analysis plan is allocated to prioritize the use of the analysis tank 50, which has a higher remaining energy count not only for the ISE electrode 1 but also for the reagents (remaining liquid volume or remaining number of measurements). Since the initial capacities of the internal standard solution bottle 3, diluent bottle 4, and comparison electrode solution bottle 5 are known, the remaining energy count of the reagents can be obtained by subtracting the amount used (number of times the bottle will be used for analysis × 1) from the initial capacity.

[0074] In this case, such as Figure 5As shown, firstly, when an analysis request is received, the control device 29 determines whether maximum processing is required (step S201). If it is determined that it is required, the processing proceeds to step S202, so that analysis is performed in all analysis tanks 50 (step S202). Conversely, if it is determined that it is not required, the processing proceeds to step S203, and it is determined whether the remaining liquid volume of the reagent in the analysis tank with the most remaining measurable count is large (step S203). If it is determined that it is large, the analysis tank 50 with the most remaining measurable count and the most remaining liquid volume is used preferentially (step S204). Conversely, if it is determined that it is not large, the analysis tank 50 with the most remaining measurable count is used preferentially through an allocation that is intermediate between the allocation in step S204 and the allocation that is performed equally (step S205).

[0075] In addition, the control device 29 expects to select the analytical cell 50 used in the measurement based not only on the number of remaining energy measurements but also on the number of samples held in the post-analysis buffer 62.

[0076] For example, if electrolyte analysis continues while there is still sample remaining in the post-analysis buffer 62, and it is determined that the sample has stalled in the post-analysis buffer 62 when analysis was performed at maximum capacity, the processing capacity is temporarily reduced to smooth the flow between the analytical cells 50 corresponding to the remaining energy measurements. Furthermore, if there is still sample remaining in the pre-analysis buffer 61 and a further analysis request for a sample is entered, any analytical cell 50 can be processed at maximum capacity. Additionally, in this case, Figure 5 Step S203 is replaced by the step of "determining whether the number of samples in the buffer after analysis is above a given amount".

[0077] Therefore, it is hoped that users will be able to select the analysis slot 50 to use first.

[0078] For example, Figure 6 The analysis slot selection screen 600 shows whether to prioritize the maximum number of processes or the validity period. Check the box 602 for the item you want to prioritize, and then press the Apply button 604 to apply the settings. To close the analysis slot selection screen 600, press the Close button 605.

[0079] also, Figure 7The analysis cell selection screen 700 shown is used by the user to select the analysis cell 50 to be performed first. As a basis for determining which cell to prioritize, the following display areas are used: a cell display area 703 showing the type of analysis cell 50; an electrode remaining energy display area 704 showing the remaining number of measurements for each ion-sensing membrane; an expiration date display area 705 showing the expiration date of the ion-sensing membrane; and a reagent status display area 706 showing the remaining energy and expiration date of each reagent. The user selects a cell based on the displayed values ​​in the checkbox 702 and presses the apply button 707 to use the analysis cell. To close the analysis cell selection screen 700, press the close button 708.

[0080] By selecting screens 600 and 700 for the analytical cell, processing capacity is maintained, and the system can handle situations where users wish to use up consumables as early as possible. Furthermore, in addition to remaining measurable capacity, ISE electrodes 1 and reagents also have a usable (valid) period, which is effective when users wish to prioritize the use of the designated analytical cell 50 and use up consumables nearing their expiration date as soon as possible.

[0081] The effects of this embodiment will now be explained.

[0082] The electrolyte analysis apparatus 100 of Embodiment 1 of the present invention described above includes: a plurality of analysis cells 50 having ISE electrodes 1 for measuring the concentration of electrolytes in a sample; and a control device 29 for controlling the operation within the electrolyte analysis apparatus 100 including the analysis cells 50. The ISE electrodes 1 of the plurality of analysis cells 50 analyze the same analytical item. The control device 29 selects the analysis cell 50 to be used in the measurement from the plurality of analysis cells 50 according to the remaining energy measurement count and measurement request status of each of the plurality of ISE electrodes 1.

[0083] Under current conditions, while it is possible to continue measurements without using the analyzer 50 where the remaining energy measurement count is zero, there is a drawback that the maximum processing capacity cannot be maintained due to the reduction in the number of analyzers 50. In contrast, by selecting the analyzer 50 to use according to, for example, the remaining energy measurement count, when the analysis request is close to the maximum processing capacity, the processing capacity can be maintained for analysis operations. Furthermore, when the request is intermittent, by prioritizing the use of analyzers 50 with higher remaining energy measurement counts, the number of remaining energy measurements across the multiple analyzers 50 can be evened out. Thus, since the timing of consumable replacement by the user can be consistent, consumable replacement can be performed at a more appropriate time than before, and the analytical capacity of each analyzer 50 can be fully utilized.

[0084] Furthermore, if the electrolyte analyzer 100 determines that the number of test requests processed within a given time is insufficient to meet the maximum processing capacity, the control device 29 prioritizes the use of the analyzer 50 with the highest remaining energy measurement count. Therefore, in contrast to maintaining the maximum processing capacity when needed, the remaining energy measurement count is smoothed out when not needed. As a result, the analytical processing capacity of the device can be utilized more flexibly, and analyses can be performed while also taking into account the replacement of consumables.

[0085] Furthermore, the control device 29 selects the analytical cell 50 used in the measurement based not only on the remaining energy measurement number but also on the remaining liquid volume of the reagent used in the analytical cell 50. This ensures that the replacement frequency of consumables containing reagents is consistent, and allows for more convenient timing of consumable replacement for the user. For example, it can make the replacement of the ISE electrode 1 and the reagent bottle consistent, thereby bringing the time when the analysis must be stopped closer together and shortening it as much as possible.

[0086] In addition, it can transport the sample container 15 after the analysis is completed to the post-analysis buffer 62 elsewhere. The control device 29 selects the analytical tank 50 used in the measurement based on the number of samples held in the post-analysis buffer 62 in addition to the number of remaining energy measurements. It can judge the processing capacity by adding the sample transport capacity, can smoothly implement the replacement frequency of consumables, and can perform analysis that is more suitable for the actual use of the device.

[0087] Furthermore, the ISE electrode 1 has an identification medium 1A for individual identification, and a reading device 1B for reading individual identification information recorded in the identification medium 1A. The control device 29 manages the remaining energy measurement number based on the individual identification information read from the reading device 1B, and can automatically perform the determination of the remaining energy measurement number on the device side.

[0088] <Example 2>

[0089] use Figures 8 to 10 The electrolyte analysis device of Embodiment 2 of the present invention will be described below. Figure 8 This is a diagram showing the overall structure of the electrolyte analysis device in Embodiment 2. Figure 9 as well as Figure 10 This is a diagram showing the screen on the display device of the electrolyte analyzer, indicating the selection of the preferred analytical cell.

[0090] Figure 8 The electrolyte analyzer 100A shown in this embodiment 2 is equipped with one corresponding quantity Figure 2 The electrolyte analysis apparatus 100 shown includes a control device 29 and a display device 80, a total of five corresponding components each with two analysis tanks 50, and structures related to transportation. Figure 8In the structure shown, the analysis slot 50 of the component used for analysis does not need to be two; it can be one or more than three.

[0091] In such an electrolyte analysis apparatus 100A, the control device 29 selects the sample probe 14 used in the dispensing process and the analytical cell 50 used in the subsequent measurement, according to the remaining energy measurement number and measurement request status of each of the multiple analytical cells 50.

[0092] For example, one can select which of the five sample probes 14 to use for sub-injection, that is, one can select which analytical unit to use for analysis.

[0093] Furthermore, when implementing such control, it is possible to use Figure 9 The betting organization selection screen shown is 800.

[0094] Figure 9 The dispensing mechanism selection screen 800 shown is used by the user to indirectly select the analytical unit of the analytical cell 50 that will perform the analysis first by selecting the sample probe 14. As a judgment factor for determining which to prioritize, various statuses are displayed in the dispensing mechanism selection area 802 (dispensing unit type), the electrode remaining energy measurement count display area 803 (remaining number of measurements for each ion sensing membrane), the expiration date display area 804 (expiration date display area for the ion sensing membrane), the reagent remaining energy measurement count display area 805 (reagent remaining energy measurement count for each reagent), and the reagent expiration date display area 806 (reagent expiration date display area for each reagent). The user selects the corresponding analytical unit in the dispensing mechanism selection area 802 based on the displayed values ​​and presses the apply button 807 to use the dispensing mechanism. To close the dispensing mechanism selection screen 800, the user presses the close button 808.

[0095] Furthermore, such as Figure 9 As shown, the analysis unit that is preferentially used in the analysis (if) Figure 9 This will be highlighted in the analysis section 4).

[0096] In addition, it is possible to select which of the 10 analysis tanks 50 in total to use preferentially. In this case, there is no particular limitation on the number of analysis tanks 50 that can be selected, and it can be set to 2 or more.

[0097] Figure 10The analysis cell selection screen 900 shown is for the user to select the analysis cell 50 to perform the analysis on priority. As a basis for determining which cell to prioritize, various statuses are displayed in the following areas: cell selection area 902 (displaying the type of analysis cell 50), electrode remaining energy measurement count display area 903 (displaying the remaining measurement counts for each ion-sensing membrane), expiration date display area 904 (displaying the expiration date of the ion-sensing membrane), reagent remaining energy measurement count display area 905 (displaying the remaining measurement counts for each reagent), and reagent expiration date display area 906 (displaying the expiration date of the reagent). The user selects the corresponding analysis cell in cell selection area 902 based on the displayed values ​​and presses the apply button 907 to begin operation. To close the analysis cell selection screen 900, press the close button 908.

[0098] Furthermore, with Figure 9 Similarly, the analysis slot 50 (if) can be prioritized for analysis. Figure 10 The analysis slots 1 of analysis unit 2, 2 of analysis unit 3, and 1 of analysis unit 4 are then highlighted.

[0099] Other structures / operations are substantially the same as those of the electrolyte analysis device in Example 1 described above, details omitted.

[0100] In the electrolyte analysis device of Embodiment 2 of the present invention, the same effect as that of the electrolyte analysis device of Embodiment 1 described above can also be obtained.

[0101] Furthermore, multiple analytical cells 50 share the sample probe 14 that dispenses samples into the analytical cells 50. With multiple sample probes 14, the control device 29 selects the sample probe 14 used for dispensing and the analytical cell 50 used for measurement based on the remaining energy measurement count and measurement request status of each of the multiple analytical cells 50. This allows for optimization of the modules used, corresponding to the remaining energy measurement count of consumables on a module-by-module basis. Consequently, the system as a whole can be managed by unifying the frequency of sample changes (or dividing it into two systems).

[0102] <Other>

[0103] Furthermore, the present invention is not limited to the embodiments described above, and includes various modifications. The embodiments described above have been given in detail for ease of understanding of the present invention, but are not necessarily limited to all the structures described.

[0104] Furthermore, a portion of the structure of one embodiment can be replaced with the structure of another embodiment. Additionally, structures from other embodiments can be added to the structure of one embodiment. Furthermore, other structures can be added to, deleted from, or replaced on a portion of the structure of each embodiment.

[0105] Explanation of reference numerals in the attached figures

[0106] 1...ISE electrode (consumable)

[0107] 1A...Identification medium

[0108] 1B...Reading device

[0109] 2... Comparison Electrode

[0110] 3...Internal standard solution bottle

[0111] 4... Diluent bottle

[0112] 5... Comparison electrode liquid bottle

[0113] 6... Suction nozzle

[0114] 7...Degassing mechanism

[0115] 8...Internal standard solution syringe

[0116] 9... Diluent syringe

[0117] 10...Liquid suction syringe

[0118] 11...Dilution tank

[0119] 12...Preheating

[0120] 13...Liquid suction tip

[0121] 14... Sample probe (dispensing mechanism)

[0122] 15... Sample Container

[0123] 16...Filters

[0124] 17, 18, 19, 20, 21, 22, 30, 31, 32... Solenoid valves

[0125] 23...Pinch valve

[0126] 24... Diluent Nozzle

[0127] 25... Internal standard liquid nozzle

[0128] 26... First waste liquid nozzle

[0129] 27...Voltmeter

[0130] 28...Amplifier

[0131] 29...Control device (control unit)

[0132] 33... Vacuum pump

[0133] 34...vacuum bottle

[0134] 35... Waste liquid collector

[0135] 36...Second waste liquid nozzle

[0136] 50...analysis slots

[0137] 55... clamp

[0138] 61...Analyze the pre-buffer zone

[0139] 62... Post-analysis buffer

[0140] 65, 66...bet line

[0141] 71...Transportation Line

[0142] 80... display device

[0143] 90... Transport Container

[0144] 100, 100A... Electrolyte Analysis Device

[0145] 501... Remaining Energy Measurement Management Screen

[0146] 503, 703... slot display area

[0147] 504... Category Display Area

[0148] 505... Remaining number of measurements display area

[0149] 506, 705, 804, 904... Expiry date display area

[0150] 508, 605, 708, 808, 908... Close button

[0151] 600, 700, 900... Analysis slot selection screen

[0152] 602, 702... checkboxes

[0153] 604, 707, 807, 907... use buttons

[0154] Display area for residual energy measurements of electrodes 704, 803, 903...

[0155] 706...Reagent Status Display Area

[0156] 800...Bet Selection Screen

[0157] 802...Between Institutions Select Area

[0158] 805, 905... Reagent Residual Energy Measurement Display Area

[0159] 806, 906... Reagent Expiration Date Display Area

[0160] 902... Slot selection area.

Claims

1. An electrolyte analysis device for analyzing the electrolyte concentration of a sample, characterized in that it comprises: Multiple analytical cells, each containing consumables for determining the concentration of electrolytes in the sample; and The control unit controls the operations within the electrolyte analysis apparatus, which includes the analysis tank. Multiple analysis slots share a dispensing mechanism that dispenses the sample into the analysis slots. The consumables in multiple of the aforementioned analytical tanks analyze the same analytical items. The control unit selects the analytical cell to be used in the measurement from the multiple analytical cells according to the remaining energy measurement count and measurement request status of each of the multiple consumables. In the case of multiple dispensing mechanisms, the control unit selects the dispensing mechanism used in dispensing according to the remaining energy measurement count and measurement request status of each of the multiple analytical cells, thereby selecting the analytical unit with the analytical cell that has priority to perform the analysis, and selecting the analytical cell to be used in the measurement.

2. The electrolyte analysis apparatus according to claim 1, characterized in that, If the electrolyte analyzer determines that the number of test requests processed within a given time is insufficient to meet the maximum processing capacity, the control unit prioritizes using the analyzer with the highest remaining capacity for testing.

3. The electrolyte analysis apparatus according to claim 1, characterized in that, The control unit selects the analytical cell to be used in the measurement based not only on the remaining energy measurement number but also on the remaining liquid volume of the reagent used in the analytical cell.

4. The electrolyte analysis apparatus according to claim 1, characterized in that, The electrolyte analysis device also includes a sample buffer section, which transports the sample container after the analysis is completed to another location. The control unit selects the analytical cell to be used in the measurement based not only on the remaining energy measurement count but also on the sample count held in the sample buffer section.

5. The electrolyte analysis apparatus according to claim 1, characterized in that, The consumable has an identification medium for individual identification. The electrolyte analysis device further includes a reading device that reads individual identification information recorded in the identification medium. The control unit manages the remaining energy measurement based on the individual identification information read by the reading device.

6. The electrolyte analysis apparatus according to claim 1, characterized in that, The control unit displays a selection screen for choosing the analytical cell to be used in the measurement.

7. The electrolyte analysis apparatus according to claim 6, characterized in that, The control unit enables the display of the remaining energy measurement quantity and the expiration date on the selection screen.

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