Microbeads for cosmetics and their applications

Abstract

The present application discloses a microbead for cosmetics and its application. The microbead comprises an oil phase and an aqueous phase. The aqueous phase is located inside the oil phase. The oil phase completely wraps the aqueous phase. The outer layer of the microbead is the oil phase and the inner layer is the aqueous phase. In the cosmetic product, the microbead is suspended in the cosmetic product. When consumers apply the microbead, the oil phase first breaks and spreads on the skin surface, and then the aqueous phase containing active ingredients slowly penetrates the oil layer to exert its effect. In this way, the concentration of active ingredients in contact with the skin can be effectively reduced, and its irritation can be reduced.

Description

Technical Field

[0001] The present invention relates to the technical field of cosmetics, and in particular to micro beads and applications thereof. Background Art

[0002] The application scope of some cosmetic active ingredients with efficacy is limited due to adverse factors such as irritation when used directly. For example, GABA (γ-aminobutyric acid) is an inhibitory neurotransmitter. Applying it to cosmetic formulas can effectively reduce skin wrinkles. This is because GABA can trigger hyperpolarization of neuronal cell membranes, open chloride ion channels, and neutralize the potential difference between the inside and outside of cells, thereby inhibiting the excitement of neuronal cells and effectively reducing muscle contraction at wrinkles. However, it is precisely because GABA acts on neuronal cells that consumers will feel a certain sense of irritation when using cosmetics containing GABA, which seriously affects the user experience of cosmetics.

[0003] In order to reduce the irritation of such active ingredients, they can be encapsulated, such as through microcapsules or liposomes, but this will affect the release of the active ingredients and the skin care effect. Summary of the invention

[0004] In response to the technical problems in the prior art of the irritation caused by active ingredients when they effectively exert their skin care effects, and the reduction of the irritation of the active ingredients while affecting the release of the active ingredients and the skin care effects, the present application provides a kind of microbeads, which can reduce the irritation of the active ingredients without affecting the skin care effects of the active ingredients.

[0005] The specific technical solutions of the present invention are as follows:

[0006] 1. A microbead, wherein the microbead comprises an oil phase and a water phase, the water phase is located inside the oil phase, and the oil phase completely encapsulates the water phase.

[0007] 2. The microbeads according to item 1, wherein the mass ratio of the oil phase to the water phase is 2-5:1.

[0008] 3. The microbeads according to item 1 or 2, wherein the oil phase comprises a thickener and an oil ester, preferably, based on the mass percentage in the oil phase, the thickener is 0.5-50%, and the oil ester is 50-99.5%.

[0009] 4. The microbead according to item 3, wherein the thickener comprises a weakly polar polymer that can form a 3D spatial network structure encapsulating the oil ester and has thermodynamic reversibility,

[0010] Preferably, the thickener comprises one or more of castor oil / IPDI copolymer, glyceryl behenate / eicosadioate, styrene / butadiene copolymer, dextrin palmitate and dibutyl ethylhexanoyl glutamine.

[0011] 5. The microbead according to item 3 or 4, wherein the oil ester comprises one or more of glycerides, hydrocarbons or ester waxes,

[0012] Preferably, the glyceride includes one or more of triglyceride, diglyceride and monoglyceride, the hydrocarbon is selected from hydrocarbons derived from petroleum components, synthetic hydrocarbons or hydrocarbons from animal and plant sources, and the ester wax includes monoesters formed by fatty acids and fatty alcohols.

[0013] More preferably, the oil ester includes one or more of caprylic / capric triglyceride, meadowfoam seed oil, shea butter, tocopheryl acetate, isopropyl palmitate, hydrogenated polyisobutene, squalane, oleic acid, and dicaprylyl carbonate.

[0014] 6. The microbead according to any one of items 1 to 5, wherein the aqueous phase contains an active ingredient, preferably, the active ingredient includes an active ingredient having a stimulating effect;

[0015] Preferably, the content of the active ingredient is 0.1-10% by mass in the aqueous phase.

[0016] 7. The microbeads according to any one of items 1 to 6, wherein the water phase further contains other ingredients in cosmetics, preferably, the other ingredients are 0.01-5% by mass percentage in the water phase.

[0017] 8. The microbeads according to any one of items 1 to 7, wherein the particle size of the microbeads ranges from 0.1 to 10 mm.

[0018] 9. Use of the microbeads described in any one of items 1 to 8 in cosmetics.

[0019] 10. The use according to item 9, wherein the microbeads are used to deliver skin care ingredients.

[0020] 11. Use of the microbeads described in any one of items 1 to 8 for reducing the irritation of active ingredients.

[0021] 12. A cosmetic preparation comprising the microbeads according to any one of claims 1 to 8.

[0022] 13. The cosmetic preparation according to item 12, wherein the cosmetic preparation is an aqueous solution, an emulsion, a gel or a cream;

[0023] Preferably, the microbeads account for 0.1-100% by mass in the cosmetic product.

[0024] Effects of the Invention

[0025] The microbeads provided by the present invention can well balance reducing the irritation of active ingredients and not affecting the release of active ingredients and skin care efficacy. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 This is a schematic diagram of a device for preparing microbeads.

[0027] Figure 2 It is a partially enlarged schematic diagram of the microchannel device in the device for preparing microbeads.

[0028] Figure 3 Schematic diagram of the microbeads prepared in Example 1.

[0029] 1-Oil phase storage tank, 2-Water phase storage tank, 3-Oil phase pump, 4-Water phase pump, 5-Microchannel device, 6-Collection tube, 7-Oil phase, 8-Water phase, 9-Channel A, 10-Channel B, 11-Channel C DETAILED DESCRIPTION

[0030] The present invention is described in detail below in conjunction with the embodiments described in the accompanying drawings, wherein the same numerals in all the accompanying drawings represent the same features. Although specific embodiments of the present invention are shown in the accompanying drawings, it should be understood that the present invention can be implemented in various forms and should not be limited by the embodiments described herein. On the contrary, these embodiments are provided in order to enable a more thorough understanding of the present invention and to fully convey the scope of the present invention to those skilled in the art.

[0031] It should be noted that certain words are used in the specification and claims to refer to specific components. Those skilled in the art should understand that technicians may use different nouns to refer to the same component. This specification and claims do not use the difference in nouns as a way to distinguish components, but use the difference in the functions of the components as the criterion for distinction. As mentioned throughout the specification and claims, "including" or "comprising" are open-ended terms and should be interpreted as "including but not limited to". The subsequent description of the specification is a preferred embodiment of the present invention, but the description is based on the general principles of the specification and is not intended to limit the scope of the present invention. The scope of protection of the present invention shall be determined by the attached claims.

[0032] The present invention provides micro beads for cosmetics, wherein the micro beads contain an oil phase and a water phase, the water phase is located inside the oil phase, and the oil phase completely encapsulates the water phase.

[0033] The microbeads provided in the present application have a water phase located inside the oil phase, and the oil phase completely wraps the water phase. When consumers use the microbeads, the oil phase will first break and spread on the skin surface, and then the water phase containing the active ingredients will slowly penetrate the oil layer to exert its effect. This can effectively reduce the concentration of the active ingredients in the water phase in contact with the skin and reduce its irritation.

[0034] In the present application, the oil phase is in a gel state, and the water phase is an aqueous solution or a hydrogel.

[0035] In some embodiments, the mass ratio of the oil phase to the water phase is 2-5:1.

[0036] For example, the mass ratio of the oil phase to the water phase (m 油相 :m 水相 ) is 2:1, 3:1, 4:1, 5:1, etc.

[0037] In the present application, the flow ratio of the oil phase and the water phase is controlled by the pump speed of the oil phase and the water phase, thereby controlling the mass ratio in the microbeads. The present application does not impose any limitation on the determination of the flow ratio of the oil phase and the water phase in the microbeads, and the detection methods commonly used in the prior art can be used. For example, the prepared microbeads can be crushed in a polytetrafluoroethylene container, and then the mass ratio of the oil phase to the water phase can be calculated by the TGA heating weight loss method.

[0038] The present application sets the mass ratio of the oil phase and the water phase in the microbeads within a specific range, which can well control the penetration rate of the active ingredients and ensure that their efficacy is not affected.

[0039] In some embodiments, the oil phase comprises a thickener and an oil ester, preferably, in terms of mass percentage in the oil phase, the thickener is 0.5-50%, and the oil ester is 50-99.5%. For example, the thickener is 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, 25%, 30%, 35%, 40%, 45%; the oil ester is 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%.

[0040] In some embodiments, the oil phase further comprises an oil-soluble active.

[0041] In some embodiments, the thickener includes a weakly polar polymer that can form a 3D spatial network structure that encapsulates oil esters and has thermodynamic reversibility. Preferably, the thickener includes one or more of castor oil / IPDI copolymer, glyceryl behenate / eicosadioate, styrene / butadiene copolymer, dextrin palmitate and dibutyl ethylhexanoyl glutamine.

[0042] In some embodiments, the oil ester includes one or more of glycerides, hydrocarbons or ester waxes. Preferably, the glycerides include one or more of triglycerides, diglycerides and monoglycerides, the hydrocarbons are selected from hydrocarbons derived from petroleum components, synthetic hydrocarbons or hydrocarbons of animal and plant origin, and the ester wax is selected from monoesters formed by fatty acids and fatty alcohols. More preferably, the oil ester includes one or more of caprylic / capric triglyceride, white meadowfoam seed oil, avocado tree fruit esters, tocopherol acetate, isopropyl palmitate, hydrogenated polyisobutene, squalane, oleic acid, and dicaprylyl carbonate.

[0043] In some embodiments, the oil-soluble active ingredients include, but are not limited to, ceramide, sphingosine, plant essential oils, oil-soluble antioxidants, essences, and the like.

[0044] In some embodiments, the aqueous phase contains an active ingredient. Preferably, the active ingredient includes an active ingredient with a stimulating effect. Preferably, the active ingredient with a stimulating effect includes one or more of aminobutyric acid, ascorbic acid, niacinamide and α-hydroxycarboxylic acid; preferably, the active ingredient is 0.1-10% by mass in the aqueous phase, for example, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, etc.

[0045] In some embodiments, the aqueous phase may also contain other ingredients in cosmetics, including but not limited to preservatives, other active ingredients, etc. Preferably, the other ingredients are 0.01-5% by mass in the aqueous phase, for example, 0.01%, 0.05%, 0.1%, 0.5%, 1%, 2%, 3%, 4%, 5%, etc.

[0046] In some embodiments, the preservative includes but is not limited to propylene glycol, butylene glycol, pentylene glycol, caprylhydroxamic acid or phenoxyethanol, etc. The other active ingredients include but are not limited to hyaluronic acid or its salt, ectoine, oligopeptides, amino acids, vitamins and / or plant extracts, etc. The oligopeptides may be, for example, carnosine, tripeptide-1 copper, acetyl hexapeptide-3, palmitoyl pentapeptide-3, palmitoyl tripeptide-5, etc.

[0047] In some embodiments, the particle size of the microbeads ranges from 0.1-10 mm, for example, 0.5 mm, 1 mm, 2 mm, 3 mm, 4 mm, 5 mm, 6 mm, 7 mm, 8 mm, 9 mm, 10 mm, etc.

[0048] In the present application, there is no limitation on the determination of the particle size of the microbeads. The particle size of the microbeads can be determined by conventional methods in the art, for example, by taking pictures with a microscope and then measuring the particle size. Preferably, the microbeads are photographed with a microscope with a ruler, and then the diameter of the microbeads in the picture is measured using software commonly used in the art. Preferably, the diameter of the microbeads in the picture is measured using ImageJ or equivalent commercial measurement software.

[0049] In the present application, there is no limitation on the preparation method of microbeads, which can be prepared by conventional methods in the art, for example, the microbeads can be obtained by mixing an oil phase and an aqueous phase.

[0050] Figure 1 Schematic diagram of a device for preparing microbeads in a specific embodiment of the present application. Figure 1 As shown, the device for preparing microbeads includes an oil phase storage tank 1, an aqueous phase storage tank 2, an oil phase pump 3, an aqueous phase pump 4, a microchannel device 5 and a collecting tube 6, wherein the outlet of the oil phase storage tank 1 is connected to the inlet of the oil phase pump 3, the outlet of the aqueous phase storage tank 2 is connected to the inlet of the aqueous phase pump 4, the inlet of the oil phase pump 3 and the inlet of the aqueous phase pump 4 are both connected to the inlet of the microchannel device 5 to prepare the microbeads, and the outlet of the microchannel device 5 is connected to the inlet of the collecting tube 6 to collect the prepared microbeads.

[0051] Figure 2 It is an enlarged schematic diagram of a microchannel device 5, wherein the microchannel device 5 includes channel A9, channel B10 and channel C11, wherein channel A9 is connected to channel C11, channel B10 is connected to channel A9 and is perpendicular to channel A9, and channel B10 is connected to channel C11 and is perpendicular to channel C11.

[0052] exist Figure 2 The oil phase 7 is mixed with the water phase 8 from the channel A 9 through the channel B10 and enters the channel C11 , thereby being collected by the collection pipe 6 .

[0053] In the present application, there is no limitation on the solvent contained in the collecting tube 6, which may be a commonly used solvent in the art, such as water.

[0054] When preparing microbeads, the oil phase solution and the water phase solution are placed in the oil phase storage tank 1 and the water phase storage tank 2 respectively, and enter the channel A and the channel B in the microchannel device 5 under the action of the oil phase pump 3 and the water phase pump 4 respectively, and enter the collection tube 6 through the channel C11 to collect the microbeads.

[0055] Those skilled in the art understand that the above combination Figure 1 The described method for preparing microbeads is merely an exemplary method. As long as the inner diameter, flow rate and other relevant parameters of the oil phase and water phase pipelines are controlled, the microbeads of the present application can be obtained. For example, microbeads in which the oil phase encapsulates the water phase can be prepared in the form of microchannels, including but not limited to "hydraulic focusing method", such as "cross-shaped" or "Y-shaped" microchannels; or "T-shaped shear method" and the like.

[0056] In the process of preparing microbeads, the morphology and size of the microbeads can be controlled by controlling the inner diameter of the microchannel, the Reynolds number of the fluid, and the shear momentum ratio of the fluid.

[0057] In some embodiments, the temperature of the oil phase storage tank 1 and the water phase storage tank 2 is not limited to any specific temperature as long as the oil phase is in a dissolved state. For example, the temperature may be 80-95°C.

[0058] In some embodiments, the flow rate of the oil phase in the oil tank pump 3 is 2-50 ml / h. For example, the flow rate of the oil phase in the oil tank pump 3 can be 2 ml / h, 5 ml / h, 10 ml / h, 15 ml / h, 20 ml / h, 25 ml / h, 30 ml / h, 35 ml / h, 40 ml / h, 45 ml / h, 50 ml / h, etc.

[0059] In some embodiments, the flow rate of the aqueous phase in the aqueous phase pump 4 is 1-20 ml / h. For example, the flow rate of the aqueous phase in the aqueous phase pump 4 can be 1 ml / h, 2 ml / h, 3 ml / h, 4 ml / h, 5 ml / h, 6 ml / h, 7 ml / h, 8 ml / h, 9 ml / h, 10 ml / h, 11 ml / h, 12 ml / h, 13 ml / h, 14 ml / h, 15 ml / h, 16 ml / h, 17 ml / h, 18 ml / h, 19 ml / h, 20 ml / h, etc.

[0060] In some embodiments, the size of channel A9 is 0.1-6.0 mm, for example, 0.1 mm, 0.2 mm, 0.3 mm, 0.4 mm, 0.5 mm, 1 mm, 1.5 mm, 2.0 mm, 2.5 mm, 3.0 mm, 3.5 mm, 4.0 mm, 4.5 mm, 5.0 mm, 5.5 mm, 6.0 mm. The size of channel C11 is 0.1-7.0 mm, for example, 1 mm, 1.5 mm, 2.0 mm, 2.5 mm, 3.0 mm, 3.5 mm, 4.0 mm, 4.5 mm, 5.0 mm, 5.5 mm, 6.0 mm, 6.5 mm, 7.0 mm.

[0061] In some embodiments, the size of channel B10 is 0.5-6.0 mm, for example, 0.5 mm, 1.0 mm, 1.5 mm, 2.0 mm, 2.5 mm, 3.0 mm, 3.5 mm, 4.0 mm, 4.5 mm, 5.0 mm, 5.5 mm, 6.0 mm. In some embodiments, the temperature of collecting tube 6 is 10-50°C, preferably 20°C.

[0062] In some embodiments, the temperature of the collecting tube 6 may be 10-50°C, for example, 10°C, 20°C, 30°C, 40°C, 50°C, etc.

[0063] The present application provides the use of the above-mentioned microbeads in cosmetics.

[0064] Furthermore, the microbeads are used to deliver skin care ingredients.

[0065] The present application also provides the use of the microbeads described above in reducing the irritation of active ingredients. The present application provides a cosmetic product comprising the microbeads described above.

[0066] In some embodiments, the cosmetic preparation is a lotion, an emulsion, a gel or a cream.

[0067] In some embodiments, the microbeads are 0.1-100% by mass in the cosmetic preparation. For example, the microbeads are 0.1%, 0.5%, 1%, 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 100%, etc. by mass in the cosmetic preparation.

[0068] In some embodiments, the cosmetic product may include other ingredients commonly used in cosmetics in addition to the microbeads. In the present application, the present application does not impose any restrictions on other commonly used ingredients, which may be conventional ingredients in the art, for example, preservatives, thickeners, flavors, functional ingredients, etc.

[0069] Example

[0070] The present invention generally and / or specifically describes the materials and test methods used in the experiments. In the following examples, unless otherwise specified, % represents wt%, i.e., weight percentage. The reagents or instruments used without indicating the manufacturer are all conventional reagent products that can be obtained commercially. Table 1 is a table of the sources of the raw materials and equipment used in the examples and comparative example 1.

[0071] Table 1 Sources of raw materials and equipment used in the examples and comparative examples

[0072]

[0073]

[0074] Example 1

[0075] like Figure 1 and Figure 2 As shown, the oil phase solution and the water phase solution are placed in the oil phase storage tank 1 and the water phase storage tank 2 respectively, the temperature of the oil phase storage tank 1 and the water phase storage tank 2 are both 85°C, and the oil phase solution and the water phase solution are respectively sent to the microchannel device 5 under the action of the oil phase pump 3 and the water phase pump 4, and the microbeads enter the collection tube 6 through the channel C. The liquid in the collection tube 6 is deionized water, and the temperature is 20°C. After the microbeads are solidified, they are filtered out with a filter to obtain microbeads, wherein the water phase is 5% GABA and 95% water, the water phase flow rate is 4mL / h, and the inner diameter of channel A is 0.6mm; the oil phase is 10% castor oil / IPDI copolymer and 90% caprylic acid / capric acid triglyceride, the oil phase flow rate is 4mL / h, the inner diameter of channel B is 0.6mm; the inner diameter of channel C is 1.1mm. The mass ratio of the oil phase to the water phase is 1:1, and the size of the microbeads is 1.52mm.

[0076] Among them, the microbeads prepared in Example 1 are as follows Figure 3 shown.

[0077] The mass ratio of the oil phase to the water phase in the prepared microbeads is determined by crushing the prepared microbeads in a polytetrafluoroethylene container, and then calculating the mass ratio of the oil phase to the water phase using the TGA heating weight loss method.

[0078] The method for determining the size of the microbeads is as follows: use ImageJ or equivalent commercial measurement software to measure the diameter of the microbeads in the image.

[0079] Example 2-22

[0080] Examples 2-22 were prepared in the same manner as Example 1, wherein:

[0081] Example 2 The water phase is 5% GABA and 95% water, the water phase flow rate is 4 mL / h, and the inner diameter of channel A is 0.6 mm; the oil phase is 10% castor oil / IPDI copolymer and 90% caprylic / capric triglyceride, the oil phase flow rate is 6 mL / h, the inner diameter of channel B is 0.6 mm; the inner diameter of channel C is 1.1 mm. The mass ratio of the oil phase to the water phase is 1.5:1, and the microbead size is 1.93 mm.

[0082] Example 3 The water phase is 5% GABA and 95% water, the water phase flow rate is 4 mL / h, and the inner diameter of channel A is 0.6 mm; the oil phase is 10% castor oil / IPDI copolymer and 90% caprylic / capric triglyceride, the oil phase flow rate is 8 mL / h, the inner diameter of channel B is 0.6 mm; the inner diameter of channel C is 1.1 mm. The mass ratio of the oil phase to the water phase is 2:1, and the microbead size is 2.01 mm.

[0083] Example 4 The aqueous phase is 5% GABA and 95% water, the aqueous phase flow rate is 4 mL / h, and the inner diameter of channel A is 0.6 mm; the oil phase is 10% castor oil / IPDI copolymer and 90% caprylic / capric triglyceride, the oil phase flow rate is 14 mL / h, the inner diameter of channel B is 0.6 mm; the inner diameter of channel C is 1.1 mm. The mass ratio of the oil phase to the aqueous phase is 3.5:1, and the microbead size is 2.09 mm.

[0084] Example 5 The water phase is 5% GABA and 95% water, the water phase flow rate is 4 mL / h, and the inner diameter of channel A is 0.6 mm; the oil phase is 10% castor oil / IPDI copolymer and 90% caprylic / capric triglyceride, the oil phase flow rate is 16 mL / h, the inner diameter of channel B is 0.6 mm; the inner diameter of channel C is 1.1 mm. The mass ratio of the oil phase to the water phase is 4:1, and the microbead size is 2.18 mm.

[0085] Example 6 The aqueous phase is 5% GABA and 95% water, the aqueous phase flow rate is 4 mL / h, and the inner diameter of channel A is 0.6 mm; the oil phase is 10% castor oil / IPDI copolymer and 90% caprylic / capric triglyceride, the oil phase flow rate is 18 mL / h, the inner diameter of channel B is 0.6 mm; the inner diameter of channel C is 1.1 mm. The mass ratio of the oil phase to the aqueous phase is 4.5:1, and the microbead size is 2.43 mm.

[0086] Example 7 The water phase is 5% GABA and 95% water, the water phase flow rate is 4 mL / h, and the inner diameter of channel A is 0.6 mm; the oil phase is 10% castor oil / IPDI copolymer and 90% caprylic / capric triglyceride, the oil phase flow rate is 22 mL / h, the inner diameter of channel B is 0.6 mm; the inner diameter of channel C is 1.1 mm. The mass ratio of the oil phase to the water phase is 5.5:1, and the microbead size is 2.52 mm.

[0087] Example 8 The water phase is 5% GABA and 95% water, the water phase flow rate is 4 mL / h, and the inner diameter of channel A is 0.7 mm; the oil phase is 10% castor oil / IPDI copolymer and 90% caprylic / capric triglyceride, the oil phase flow rate is 24 mL / h, the inner diameter of channel B is 0.7 mm; the inner diameter of channel C is 1.5 mm. The mass ratio of the oil phase to the water phase is 6:1, and the microbead size is 2.83 mm.

[0088] Example 9 The aqueous phase is 5% GABA and 95% water, the aqueous phase flow rate is 4 mL / h, and the inner diameter of channel A is 3.0 mm; the oil phase is 10% castor oil / IPDI copolymer and 90% caprylic / capric triglyceride, the oil phase flow rate is 40 mL / h, the inner diameter of channel B is 3.0 mm; the inner diameter of channel C is 6.5 mm. The mass ratio of the oil phase to the aqueous phase is 10:1, and the microbead size is 8.45 mm.

[0089] Example 10 The aqueous phase is 5% GABA and 95% water, the aqueous phase flow rate is 4 mL / h, and the inner diameter of channel A is 1.5 mm; the oil phase is 10% castor oil / IPDI copolymer and 90% caprylic / capric triglyceride, the oil phase flow rate is 12 mL / h, the inner diameter of channel B is 1.5 mm; the inner diameter of channel C is 2.8 mm. The mass ratio of the oil phase to the aqueous phase is 3:1, and the microbead size is 4.58 mm.

[0090] Example 11 The aqueous phase is 5% GABA and 95% water, the aqueous phase flow rate is 4 mL / h, and the inner diameter of channel A is 1.7 mm; the oil phase is 10% castor oil / IPDI copolymer and 90% caprylic / capric triglyceride, the oil phase flow rate is 12 mL / h, the inner diameter of channel B is 1.7 mm; the inner diameter of channel C is 3.5 mm. The mass ratio of the oil phase to the aqueous phase is 3:1, and the microbead size is 6.75 mm.

[0091] Example 12 The aqueous phase is 5% GABA and 95% water, the aqueous phase flow rate is 4 mL / h, and the inner diameter of channel A is 3.0 mm; the oil phase is 10% castor oil / IPDI copolymer and 90% caprylic / capric triglyceride, the oil phase flow rate is 12 mL / h, the inner diameter of channel B is 3.0 mm; the inner diameter of channel C is 6.5 mm. The mass ratio of the oil phase to the aqueous phase is 3:1, and the microbead size is 9.38 mm.

[0092] Example 13 The water phase is 5% GABA and 95% water, the water phase flow rate is 4 mL / h, and the inner diameter of channel A is 0.6 mm; the oil phase is 10% castor oil / IPD copolymer, 56% caprylic / capric triglyceride, 34% white meadowfoam seed oil, the oil phase flow rate is 12 mL / h, the inner diameter of channel B is 0.6 mm; the inner diameter of channel C is 1.1 mm. The mass ratio of the oil phase to the water phase is 3:1, and the microbead size is 2.35 mm.

[0093] Example 14 The water phase is 5% GABA and 95% water, the water phase flow rate is 4 mL / h, and the inner diameter of channel A is 0.6 mm; the oil phase is 10% castor oil / IPD copolymer, 53% caprylic / capric triglyceride, 34% white meadowfoam seed oil, 3% avocado esters, the oil phase flow rate is 12 mL / h, the inner diameter of channel B is 0.6 mm; the inner diameter of channel C is 1.1 mm. The mass ratio of the oil phase to the water phase is 3:1, and the microbead size is 2.04 mm.

[0094] Example 15 The water phase is 5% GABA and 95% water, the water phase flow rate is 4 mL / h, and the inner diameter of channel A is 0.6 mm; the oil phase is 10% castor oil / IPDI copolymer, 40% dioctyl carbonate, 30% white meadowfoam seed oil, 10% squalane, 5% avocado esters, 5% tocopherol acetate, the oil phase flow rate is 12 mL / h, the inner diameter of channel B is 0.6 mm; the inner diameter of channel C is 1.1 mm. The mass ratio of the oil phase to the water phase is 3:1, and the microbead size is 2.39 mm.

[0095] Example 16 The aqueous phase is 5% GABA and 95% water, the aqueous phase flow rate is 4 mL / h, and the inner diameter of channel A is 1.5 mm; the oil phase is 10% castor oil / IPDI copolymer, 40% dioctyl carbonate, 30% hydrogenated polyisobutylene, 10% squalane, 5% oleic acid, 5% isopropyl palmitate, the oil phase flow rate is 12 mL / h, the inner diameter of channel B is 1.5 mm; the inner diameter of channel C is 2.8 mm. The mass ratio of the oil phase to the aqueous phase is 3:1, and the microbead size is 4.91 mm.

[0096] Example 17 The water phase is 5% GABA and 95% water, the water phase flow rate is 4 mL / h, and the inner diameter of channel A is 0.6 mm; the oil phase is 3% glyceryl behenate / eicosandioate, 40% caprylic / capric triglyceride, 30% dicaprylyl carbonate, 20% hydrogenated polyisobutene, and 7% squalane, the oil phase flow rate is 12 mL / h, the inner diameter of channel B is 0.6 mm; the inner diameter of channel C is 1.1 mm. The mass ratio of the oil phase to the water phase is 3:1, and the microbead size is 2.35 mm.

[0097] Example 18 The aqueous phase is 5% GABA and 95% water, the aqueous phase flow rate is 4 mL / h, and the inner diameter of channel A is 0.6 mm; the oil phase is 3% dextrin palmitate, 50% dicaprylyl carbonate, 40% caprylic / capric triglyceride, and 7% isopropyl palmitate, the oil phase flow rate is 12 mL / h, the inner diameter of channel B is 0.6 mm; the inner diameter of channel C is 1.1 mm. The mass ratio of the oil phase to the aqueous phase is 3:1, and the microbead size is 2.02 mm.

[0098] Example 19 The aqueous phase is 5% GABA and 95% water, the aqueous phase flow rate is 4 mL / h, and the inner diameter of channel A is 0.6 mm; the oil phase is 0.2% castor oil / IPDI copolymer, 99.8% caprylic / capric triglyceride, the oil phase flow rate is 12 mL / h, the inner diameter of channel B is 0.6 mm; the inner diameter of channel C is 1.1 mm. The mass ratio of the oil phase to the aqueous phase is 3:1, and the microbead size is 2.52 mm.

[0099] Example 20 The water phase is 5% GABA and 95% water, the water phase flow rate is 4 mL / h, and the inner diameter of channel A is 0.6 mm; the oil phase is 0.2% castor oil / IPDI copolymer, 90% caprylic / capric triglyceride, 9.8% dicaprylyl carbonate, the oil phase flow rate is 12 mL / h, the inner diameter of channel B is 0.6 mm; the inner diameter of channel C is 1.1 mm. The mass ratio of the oil phase to the water phase is 3:1, and the microbead size is 2.51 mm.

[0100] Example 21 The aqueous phase is 5% GABA and 95% water, the aqueous phase flow rate is 4 mL / h, and the inner diameter of channel A is 0.7 mm; the oil phase is 55% castor oil / IPDI copolymer, 45% caprylic / capric triglyceride, the oil phase flow rate is 12 mL / h, the inner diameter of channel B is 0.7 mm; the inner diameter of channel C is 1.5 mm. The mass ratio of the oil phase to the aqueous phase is 3:1, and the microbead size is 2.86 mm.

[0101] Example 22 The aqueous phase is 10% ascorbic acid and 90% water, the aqueous phase flow rate is 4 mL / h, and the inner diameter of channel A is 0.7 mm; the oil phase is 90% caprylic / capric triglyceride, the oil phase flow rate is 12 mL / h, the inner diameter of channel B is 0.7 mm; the inner diameter of channel C is 1.5 mm. The mass ratio of the oil phase to the aqueous phase is 3:1, and the microbead size is 2.85 mm.

[0102] Comparative Example 1

[0103] The difference between Comparative Example 1 and Example 11 is that in Comparative Example 1, the oil gel particles and the aqueous phase solution are physically mixed, wherein the mass ratios of the aqueous phase component, the oil gel particle component (oil phase component), the oil gel particles and the aqueous phase are as shown in Table 2.

[0104] Comparative Example 2

[0105] The difference between Comparative Example 2 and Example 11 is that in Comparative Example 2, the liquid oil phase and the aqueous phase solution are physically mixed, wherein the mass ratios of the aqueous phase component, the liquid oil phase component, the liquid oil phase component and the aqueous phase are as shown in Table 2.

[0106] Comparative Example 3

[0107] The difference between Comparative Example 3 and Example 11 is that in Comparative Example 3, the oil gel particles and the aqueous phase solution are physically mixed, wherein the mass ratios of the aqueous phase component, the oil gel particle component (oil phase component), the oil gel particles and the aqueous phase are as shown in Table 2.

[0108] Table 2 Reaction conditions of the embodiments and comparative examples

[0109]

[0110]

[0111] Experimental Example 1: Evaluation of irritation and wrinkles after using GABA

[0112] A. Irritation Evaluation

[0113] (1) Evaluation method: This method objectively evaluates the irritation intensity and irritation difference of different samples. A 3% GABA aqueous solution is used to screen GABA-sensitive people. The score is set on a scale of 1-5. First, the subjects are trained to perceive the irritation of 1 and 5 points respectively. Then, the subjects evaluate the irritation caused by the actual samples based on this criterion.

[0114] Among them, the screening method for GABA-sensitive population is:

[0115] 20 μL of solution was taken and applied around the eyes of the subjects, with physiological saline and 3% GABA aqueous solution applied on the left and right sides respectively. After about 1 minute of reaction, the subjects were asked about the tingling sensation; the subjects who reacted to the 3% GABA sample (felt tingling sensation) were selected; finally, 10 GABA-sensitive subjects were screened out, including 3 men and 7 women, who were office white-collar workers aged between 27 and 40, with an average age of 33.

[0116] The criteria for irritation rating are:

[0117] The score was set to 1-5 points, where the stimulation caused by 5% GABA aqueous solution was defined as 1 point and the stimulation caused by normal saline was defined as 5 points. The specific evaluation criteria are shown in Table 3.

[0118] Table 3 Irritation evaluation standards

[0119] 1 The stinging sensation is severe and totally unacceptable 2 The stinging sensation is strong and not very acceptable 3 Feel the sting, acceptable 4 Slightly painful, acceptable 5 No stimulation, acceptable

[0120] (2) Sample testing:

[0121] a: Negative control and positive control: 0.6% NaCl solution was used as negative control, and 5% GABA solution was used as positive control; the method was to draw 20 μL of 0.6% NaCl solution, apply it evenly to the corner of the subject's eye, react for about 1 minute, ask the subject about the irritation, the subject responded that there was no irritation, and tell the subject to define the irritation as 1 point. Subsequently, draw 20 μL of 5% GABA aqueous solution, apply it evenly to the corner of the subject's eye, react for about 1 minute, ask the subject about the irritation, and tell the subject to define the irritation as 5 points.

[0122] b: Sample test: Wipe the area around the eyes with a wet tissue, and let it recover for 10-15 minutes. Then, perform a sample test. Take 10 microbeads prepared in Examples 1-21 and place them on the fingertips. Press and apply them to the corners of the eyes one by one. Massage up and down 20 times until completely absorbed. Let it react for about 1-2 minutes. Ask the subjects to describe the stinging pain on their faces, and rate the intensity of the stimulation. The results are shown in Table 5.

[0123] c: Physical mixture sample test of oil gel particles and GABA aqueous solution: wipe the area around the eyes with a wet tissue, recover for 10-15 minutes, and then conduct a sample test. The method is to take 10 oil gel microbeads and place them at the corner of the eye. At this time, the subject needs to raise his head slightly to keep the microbeads at the corner of the eye, and then quickly absorb 10μL GABA aqueous solution into the corner of the eye, and quickly apply the oil gel and GABA aqueous solution at the same time, massage up and down 20 times until completely absorbed, and react for about 1min to 2min. Ask the subject about the tingling on the face and describe it, and score the intensity of this stimulation. The results are shown in Table 5.

[0124] d: Physical mixed sample test of liquid oil phase and GABA aqueous solution: Wipe the area around the eyes with a wet tissue, recover for 10-15 minutes, and then conduct a sample test. Pipette 40 μL of the mixed emulsion and place it at the corner of the eye. Massage up and down 20 times until it is completely absorbed. The reaction lasts for about 1-2 minutes. Ask the subjects to describe the stinging pain on their faces, and rate the intensity of the stimulation. The results are shown in Table 5.

[0125] B. Wrinkle Assessment

[0126] (1) Wrinkle evaluation method: This method objectively evaluates the wrinkle removal effect of different samples by comparing the half of the face before and after application with the other half without any ingredients, and gives a comprehensive score. The score is set on a scale of 1-5, where 5 points represent a very obvious wrinkle removal effect and 1 point represents no wrinkle removal effect. The inclusion criteria for the subjects were: a total of 10 people, 3 males and 7 females, aged 27 to 40 years old, with an average age of 33 years old, and wrinkle grades 3 to 5.

[0127] The score is set on a scale of 1-5, with 1 representing no wrinkle-removing effect and 5 representing a very obvious wrinkle-removing effect. The specific scoring criteria are shown in Table 4.

[0128] Table 4 Wrinkle scoring criteria

[0129]

[0130]

[0131] The wrinkle length is measured as follows:

[0132] The corner of the eye was selected, and the Visia device imaging system was used to record the wrinkle length before and after application, and the change in wrinkle length was calculated.

[0133] (2) Sample testing:

[0134] a: Sample test: Wipe the corner of the eye with a wet tissue, let it recover for 10-15 minutes, observe the wrinkle degree before application, take 10 microbeads prepared in Examples 1-21 respectively, place them on the fingertips, press and apply to the corner of the eye, massage up and down 20 times until completely absorbed, react for 10 minutes, gently wipe off the excess oil in the corner of the eye with a tissue, observe the wrinkles before application and the other side of the eye, and score. The results are shown in Table 5.

[0135] b: Test of oil gel microbeads and GABA aqueous solution samples: wipe the corners of the eyes with a wet tissue, recover for 10-15 minutes, observe the degree of wrinkles before application, and then conduct sample testing. The amount of oil phase and GABA aqueous solution added is consistent with the amount of oil gel-water added. The method is to take 10 oil gel microbeads and place them at the corners of the eyes. At this time, the subject needs to raise his head slightly to keep the microbeads at the corners of the eyes, and then quickly absorb 10μL GABA aqueous solution into the corners of the eyes, and quickly apply the oil gel and GABA aqueous solution at the same time, massage up and down 20 times until completely absorbed. After reacting for 10 minutes, gently wipe off the surface oil with a tissue, and observe and score the wrinkles before and on the other side of the eye. The results are shown in Table 5.

[0136] c: Oil-water homogeneous mixed liquid sample test: wipe the corner of the eye with a wet tissue, let it recover for 10-15 minutes, observe the wrinkle degree before application, and then conduct sample test, take 40μL of mixed emulsion and place it at the corner of the eye, after application, the subject will rate the irritation. Massage up and down 20 times until it is completely absorbed, react for 10 minutes, gently wipe off the surface oil with a tissue, observe the wrinkles before application and the other side of the eye corner and rate them, the results are shown in Table 5.

[0137] Table 5 Irritation score and wrinkle score results

[0138]

[0139]

[0140] Experimental Example 2 Irritation Test after Using Ascorbic Acid

[0141] The samples obtained in Example 22 and Comparative Example 3 were applied on the curved side of the forearm of the subjects (the subjects were females aged 25 to 35 years old, working in offices as clerical workers. They wore thin long-sleeved clothing during the test to avoid excessive UV exposure, and no skin care products or sunscreen products were applied on the forearms during the test) for 10 consecutive days, twice a day. After 10 days, the L, a and b values ​​of the applied areas were tested using a NS800 spectrophotometer (3nh), where L represents the white-black value, a represents the red-green value, and b represents the yellow-blue value.

[0142] Among them, when the L value increased by 5% and the b value decreased by 6% after 10 days, the subjects using the sample of Example 22 had no irritation, while the subjects using the sample of Comparative Example 3 had significant irritation, indicating that the microbeads can reduce the irritation of ascorbic acid.

[0143] The above is only a preferred embodiment of the present invention, and does not limit the present invention in other forms. Any technician familiar with the profession may use the above disclosed technical content to change or modify it into an equivalent embodiment with equivalent changes. However, any simple modification, equivalent change and modification made to the above embodiment according to the technical essence of the present invention without departing from the technical solution of the present invention still belongs to the protection scope of the technical solution of the present invention.

Claims

1. A microbead, wherein: The microbeads contain an oil phase and a water phase, wherein the water phase is located inside the oil phase, and the oil phase completely encapsulates the water phase; The mass ratio of the oil phase to the water phase is 2-5:1; The oil phase comprises a thickener and an oil ester, wherein the thickener accounts for 0.5-50% and the oil ester accounts for 50-99.5% by mass in the oil phase; The thickener includes one or more of castor oil / IPDI copolymer, glyceryl behenate / eicosanedioate, styrene / butadiene copolymer, dextrin palmitate and dibutyl ethylhexanoyl glutamine; The oil ester includes one or more of glycerides, hydrocarbons or ester waxes.

2. The microbead according to claim 1, wherein The glyceride includes one or more of triglyceride, diglyceride and monoglyceride, the hydrocarbon is selected from hydrocarbons derived from petroleum components, artificially synthesized hydrocarbons or hydrocarbons of animal and plant origin, and the ester wax includes monoesters formed by fatty acids and fatty alcohols.

3. The microbead according to claim 1, wherein The oil ester includes one or more of caprylic / capric triglyceride, meadowfoam seed oil, avocado oil, tocopherol acetate, isopropyl palmitate, hydrogenated polyisobutene, squalane, oleic acid, and dicaprylyl carbonate.

4. The microbead according to any one of claims 1 to 3, wherein The aqueous phase contains the active ingredient.

5. The microbead according to claim 4, wherein The active ingredients include active ingredients having a stimulating feel.

6. The microbead according to claim 4, wherein The content of the active ingredient is 0.1-10% by mass percentage in the water phase.

7. The microbead according to any one of claims 1 to 3, wherein The aqueous phase also contains other ingredients in the cosmetic.

8. The microbead according to claim 7, wherein Calculated by mass percentage in the water phase, the other components are 0.01-5%.

9. The microbead according to any one of claims 1 to 7, wherein The particle size of the microbeads ranges from 0.1 to 10 mm.

10. Use of the microbeads according to any one of claims 1 to 9 in preparing cosmetics.

11. The use according to claim 10, wherein: The microbeads are used to deliver skin care ingredients.

12. Use of the microbeads according to any one of claims 1 to 9 in preparing products that reduce the irritation of active ingredients.

13. A cosmetic preparation comprising the microbeads according to any one of claims 1 to 9.

14. The cosmetic preparation according to claim 13, wherein: The cosmetic product is an aqueous solution, emulsion, gel or cream.

15. The cosmetic preparation according to claim 13 or 14, wherein the microbeads account for 0.1-100% by mass in the cosmetic preparation.

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