A kind of tooth whitening gel and preparation method thereof

Abstract

The present application discloses a tooth whitening gel and a preparation method thereof, wherein the gel comprises the following raw materials in parts by weight: 5 to 10 parts of peroxide; 20 to 40 parts of binder; 5 to 10 parts of tackifier; 0.5 to 2 parts of desensitizer; 0.01 to 0.1 parts of catalyst; and the balance of water; the binder is an organic silicon modified acrylic resin. The tooth whitening gel of the present application has excellent durability, and its active ingredients are not easily dissolved and diluted by saliva, which is conducive to matching the dissolution rate of the active ingredients with the tooth bleaching rate, fully acting and improving the tooth whitening effect.

Description

Technical Field

[0001] The present application relates to the field of tooth whitening drugs, and in particular to a tooth whitening gel and a preparation method thereof. Background Art

[0002] Teeth whitening gel is a whitening product with a gel-like viscous substance as the base material and an oxidizing compound as the active ingredient. When used, the gel is adhered to the surface of the teeth to deliver the active ingredients to the teeth, discoloring the teeth and achieving a good whitening effect.

[0003] Teeth whitening gels on the market are usually based on hydrophilic gel, which causes the active ingredients in the gel to be easily dissolved and diluted by saliva, thereby reducing the durability and whitening effect of the gel. Summary of the invention

[0004] The present application provides a teeth whitening gel and a preparation method thereof, wherein the gel can have better durability and achieve a longer-lasting teeth whitening effect.

[0005] In a first aspect, the present application provides a tooth whitening gel, which comprises the following raw materials in parts by weight:

[0006] Peroxide: 5-10 parts;

[0007] Binder: 20-40 parts;

[0008] Thickener: 5-10 parts;

[0009] Desensitizer: 0.5-2 parts;

[0010] Catalyst: 0.01-0.1 part;

[0011] Water: balance;

[0012] The adhesive is silicone-modified acrylic resin.

[0013] Since silicone-modified acrylic resin has both hydrophilic and hydrophobic groups, it can effectively inhibit the rapid dissolution and dilution of the active ingredients in the gel by saliva while playing the role of carrying and delivering the active ingredients, thereby ensuring its durability.

[0014] Other components may be added to the gel raw material of the present application according to the needs of use, including but not limited to antibacterial agents, antioxidants, flavors, flavoring agents, vitamins, minerals, amino acids, and analgesics.

[0015] Preferably, the peroxide is selected from one or a combination of hydrogen peroxide, sodium percarbonate, calcium peroxide, urea peroxide, persulfate, and perborate.

[0016] Peroxide, as the main active ingredient of teeth whitening gel, has an oxidative bleaching effect. It can react under the catalysis of a catalyst and remove pigments on the surface of teeth to achieve a whitening effect.

[0017] Preferably, the desensitizing agent is selected from one or a combination of strontium chloride, potassium nitrate, sodium monofluorophosphate, and fluoride.

[0018] Preferably, the viscosity enhancer is selected from one or a combination of polyvinyl pyrrolidone, sorbitol, hydroxyethyl cellulose, sodium carboxymethyl cellulose, sodium alginate, gelatin, xanthan gum, and polyvinyl alcohol.

[0019] The above-mentioned viscosity enhancer is a hydrophilic viscous material, which can enhance the viscosity of the adhesive substrate and promote the formation of gel film on the tooth surface; it also has a water-retaining and moisturizing effect, which is beneficial to promote the release and delivery of active ingredients to the tooth surface.

[0020] Preferably, the catalyst is an alkaline catalyst.

[0021] Typically, but not limiting, the alkaline catalyst is sodium hydroxide.

[0022] The tooth whitening gel of the present application may be added with other additives according to product requirements, including but not limited to preservatives, surfactants, antibacterial agents, anti-inflammatory agents, and antioxidants.

[0023] Preferably, in parts by weight, the polymerizable monomers of the organosilicon-modified acrylic resin include:

[0024] Soft monomer: 40-50 parts;

[0025] Hard monomer: 30-40 parts;

[0026] Unsaturated silicone monomer: 10-20 parts;

[0027] The unsaturated silicone monomer is selected from one or a combination of vinyl trimethoxysilane, octamethylcyclotetrasiloxane and methacryloxypropyl trimethoxysilane.

[0028] Preferably, the soft monomer includes but is not limited to one or more of acrylic acid, hydroxyethyl acrylate, ethyl acrylate, and butyl acrylate; the hard monomer includes but is not limited to one or more of styrene, acrylonitrile, methyl acrylate, and methyl methacrylate.

[0029] Preferably, the amount of the emulsifier is 2-5 wt% of the amount of the polymerization monomer, and the amount of the initiator is 1-3 wt% of the amount of the polymerization monomer.

[0030] By adopting the above-mentioned polymerized monomers, hydrophobic organosilicon groups are introduced into the acrylic resin, thereby giving the hydrophilic acrylic resin a certain hydrophobicity, prolonging the release time of the active ingredients in the whitening gel and improving its durability.

[0031] Preferably, the preparation method of the organosilicon-modified acrylic resin is as follows:

[0032] Emulsification: adding soft monomer, hard monomer and at least 50 wt% of unsaturated silicone monomer to the emulsifier solution, dispersing evenly to obtain an emulsion;

[0033] Core layer polymerization: add the emulsion into sodium bicarbonate buffer, heat to 75-88°C, stir evenly, then add at least 90wt% of initiator solution, stir and react to obtain a core layer polymerization product;

[0034] Shell polymerization: add the remaining unsaturated silicone monomer and initiator solution to the core polymerization product, stir and react, and after the reaction is completed, cool and cool to obtain silicone-modified acrylic resin.

[0035] The efficiency of silicone monomers in participating in polymerization is low due to the hydrolysis and condensation phenomenon. In the emulsion polymerization of the present application, a step-by-step polymerization process is adopted, and some unsaturated silicone monomers are added in the later stage of the reaction, so that the content of hydrophobic silicone distributed on the surface of the emulsion particles is higher, which is beneficial to improve the durability of the whitening gel.

[0036] Preferably, in the shell polymer step, after the reaction is completed, a methoxy-terminated silicone oil with a viscosity of 30 to 100 cp is added, and the mass ratio of the methoxy-terminated silicone oil to the unsaturated silicone monomer is 5 to 15:10 to 20. The molecular structure of the methoxy-terminated silicone oil is as follows:

[0037]

[0038] The methoxy-terminated silicone oil is hydrolyzed to form a terminal hydroxyl silicone oil, which has a certain reactivity and can react and bond with the silanol groups on the surface of the emulsion particles, thereby improving the hydrophobicity of the silicone-modified acrylic resin and the durability of the whitening gel. The methoxy-terminated silicone oil can be obtained from Runhe Silicone, and the product models include RH-Z30, RH-Z50, etc.

[0039] Preferably, the tackifier is polyvinyl alcohol.

[0040] The alcoholic hydroxyl groups of polyvinyl alcohol can form hydrogen bonds with the carbonyl groups in the acrylic resin segments and the silanol groups in the silicone segments, playing a stabilizing role and preventing the unreacted methoxy-terminated silicone oil from precipitating and accumulating on the gel surface, affecting the release of active ingredients to the tooth surface.

[0041] Preferably, the raw material further comprises 0.5-2% of an accelerator, and the accelerator is PEG-10 polydimethylsiloxane or lauryl PEG-8 polydimethylsiloxane.

[0042] The silicone segments in the silicone acrylic resin repel hydrophilic substances such as saliva, which will block the release of some active ingredients to a certain extent, reduce the migration release rate of the effective ingredients, and are not conducive to the full play of the whitening effect of the active ingredients. The use of the above-mentioned accelerator can prevent the above phenomenon and is conducive to improving the final teeth whitening effect. In addition, the above-mentioned accelerator can improve the compatibility of the aforementioned unreacted silicone oil with the silicone acrylic resin and inhibit the precipitation of silicone oil.

[0043] In a second aspect, the preparation method of the tooth whitening gel comprises the following steps:

[0044] Premixing: Add the aqueous acrylic emulsion into water and disperse it evenly, then add the peroxide, desensitizer and tackifier, mix evenly under vacuum conditions to obtain a premixed solution;

[0045] Gel preparation: Dissolve the catalyst in water, add it dropwise into the premixed liquid under vacuum conditions for dispersion and degassing to obtain a teeth whitening gel.

[0046] Preferably, the vacuum degree of the vacuum condition is -0.08-0.1 MPa.

[0047] Preferably, the concentration of the catalyst after dissolution is 5 to 10 wt%.

[0048] In summary, this application has the following beneficial effects:

[0049] 1. This application adopts silicone-modified acrylic resin as the binder of the whitening gel, which can effectively reduce the dissolution and dilution rate of the active ingredients in the gel by saliva while ensuring the gel's transmission effect on the active ingredients, thereby improving the durability of the gel's whitening effect.

[0050] 2. The silicone-modified acrylic resin of the present application can significantly increase the content of silicone segments in the resin, especially on the surface of the resin, by adopting unsaturated silicone monomers and a segmented polymerization process, thereby giving the gel a certain hydrophobicity, inhibiting the dissolution and dilution rate of the active ingredients in the gel, and improving the durability of the whitening gel.

[0051] 3. The present application can significantly increase the content and hydrophobicity of the silicone hydrophobic segment of the acrylic resin and improve the durability of the whitening gel by blending the low molecular weight methoxy-terminated silicone oil with the acrylic resin during the polymerization process. DETAILED DESCRIPTION

[0052] Preparation examples of raw materials and / or intermediates

[0053] Preparation Example 1: A silicone-modified acrylic resin is prepared according to the following steps:

[0054] Emulsification: Add 0.2 kg AEO-9, 0.1 kg sodium dodecyl sulfate and 8 kg pure water into a stirring kettle to prepare an emulsifier solution. Take 90% of the emulsifier solution and add it into the reaction kettle, then add 2.5 kg acrylic acid, 2 kg hydroxyethyl acrylate, 4 kg methyl methacrylate, 0.2 kg octamethylcyclotetrasiloxane, and 0.6 kg methacryloyloxypropyl trimethoxysilane, and disperse evenly to obtain an emulsion.

[0055] Core layer polymerization: add the emulsion into 3 kg of sodium bicarbonate buffer (10 wt%), heat to 80°C, stir evenly, then add 1.9 kg of 10 wt% sodium persulfate solution, react under stirring, and obtain the core layer polymerization product after 6 hours.

[0056] Shell polymerization: add 0.7 kg of methacryloyloxypropyltrimethoxysilane, 0.1 kg of 10 wt% sodium persulfate solution and the remaining 10% of the emulsifier solution to the core polymerization product, stir and react at 80°C for 3 hours, and cool after the reaction is completed to obtain a silicone-modified acrylic resin.

[0057] Preparation Example 2, a silicone-modified acrylic resin, is prepared according to the following steps:

[0058] Emulsification: Add 0.15 kg AEO-9, 0.05 kg sodium dodecyl sulfate and 8 kg pure water into a stirring kettle to prepare an emulsifier solution. Take 90% of the emulsifier solution and add it into the reaction kettle, then add 3 kg acrylic acid, 1 kg hydroxyethyl acrylate, 4 kg methyl methacrylate, 0.3 kg octamethylcyclotetrasiloxane, and 0.9 kg methacryloyloxypropyl trimethoxysilane, and disperse evenly to obtain an emulsion.

[0059] Core layer polymerization: add the emulsion into 3 kg of sodium bicarbonate buffer (10 wt%), heat to 78°C, stir evenly, then add 1.8 kg of 10 wt% sodium persulfate solution, react under stirring, and obtain the core layer polymerization product after 7 hours.

[0060] Shell polymerization: add 0.8 kg of methacryloyloxypropyltrimethoxysilane, 0.2 kg of 10 wt% sodium persulfate solution and the remaining 10% of the emulsifier solution to the core polymerization product, stir and react at 78°C for 3 hours, and cool after the reaction is completed to obtain a silicone-modified acrylic resin.

[0061] Preparation Example 3, a silicone-modified acrylic resin is prepared according to the following steps:

[0062] Emulsification: Add 0.2 kg AEO-9, 0.1 kg sodium dodecyl sulfate and 8 kg pure water into a stirring kettle to prepare an emulsifier solution. Take 90% of the emulsifier solution and add it into the reactor, then add 3 kg acrylic acid, 2 kg hydroxyethyl acrylate, 4 kg methyl methacrylate, 0.2 kg octamethylcyclotetrasiloxane, and 0.4 kg methacryloyloxypropyl trimethoxysilane, and disperse evenly to obtain an emulsion.

[0063] Core layer polymerization: add the emulsion into 3 kg of sodium bicarbonate buffer (10 wt%), heat to 85°C, stir evenly, then add 1.9 kg of 10 wt% sodium persulfate solution, react under stirring, and obtain the core layer polymerization product after 6 hours.

[0064] Shell polymerization: add 0.4 kg of methacryloyloxypropyltrimethoxysilane, 0.1 kg of 10 wt% sodium persulfate solution and the remaining 10% of the emulsifier solution to the core polymerization product, stir and react at 85°C for 3 hours. After the reaction is completed, cool and cool to obtain a silicone-modified acrylic resin.

[0065] Preparation Example 4, a silicone-modified acrylic resin, without step-by-step polymerization, the specific preparation method is as follows:

[0066] Emulsification: Add 0.2 kg AEO-9, 0.1 kg sodium dodecyl sulfate and 8 kg pure water into a stirring kettle to prepare an emulsifier solution. Add the emulsifier solution into the reactor, then add 2.5 kg acrylic acid, 2 kg hydroxyethyl acrylate, 4 kg methyl methacrylate, 0.5 kg octamethylcyclotetrasiloxane, and 1 kg methacryloyloxypropyl trimethoxysilane, disperse evenly to obtain an emulsion.

[0067] Core layer polymerization: add the emulsion into 3 kg of sodium bicarbonate buffer (10 wt%), heat to 80°C, stir evenly, then add 2 kg of 10 wt% sodium persulfate solution, react for 9 hours under stirring, cool after the reaction is completed, and obtain silicone-modified acrylic resin.

[0068] Preparation Example 5, a silicone-modified acrylic resin, is different from Preparation Example 1 in that methoxy-terminated silicone oil is added in the shell polymerization step, and the operation is as follows:

[0069] Add 0.4 kg of methacryloyloxypropyltrimethoxysilane, 0.1 kg of 10 wt% sodium persulfate solution and the remaining 10% of the emulsifier solution to the core layer polymerization product, stir and react at 80°C for 3 hours, add 1.2 kg of methoxy-terminated silicone oil (viscosity 45-55 cp) after the reaction is completed, continue stirring and reacting for 1.5 hours, cool and cool to obtain a silicone-modified acrylic resin.

[0070] Example

[0071] Example 1, a tooth whitening gel, prepared according to the following method:

[0072] Premixing: Add the organosilicon-modified acrylic resin obtained in Preparation Example 1 into water, stir for 30 minutes, and disperse evenly; then add urea peroxide, sodium monofluorophosphate, potassium nitrate and PVP, and continue stirring for 30 minutes under a vacuum condition of -0.08 to -0.1 MPa to obtain a premixed solution;

[0073] Preparation of gel: dissolve sodium hydroxide in water to prepare a 10wt% catalytic solution; under vacuum conditions of -0.08 to -0.1MPa, drop the catalyst solution into the premixed solution and stir for 40 minutes; finally, degas the solution under vacuum and stirring to prepare a teeth whitening gel.

[0074] Example 2, a tooth whitening gel, prepared according to the following method:

[0075] Premixing: Add the organosilicon-modified acrylic resin obtained in Preparation Example 2 into water, stir for 30 minutes, and disperse evenly; then add urea peroxide, sodium monofluorophosphate, potassium nitrate and PVP, and continue stirring for 30 minutes under a vacuum condition of -0.08 to -0.1 MPa to obtain a premixed solution;

[0076] Preparation of gel: dissolve sodium hydroxide in water to prepare a 10wt% catalytic solution; under vacuum conditions of -0.08 to -0.1MPa, drop the catalyst solution into the premixed solution and stir for 40 minutes; finally, degas the solution under vacuum and stirring to prepare a teeth whitening gel.

[0077] Example 3, a tooth whitening gel, prepared according to the following method:

[0078] Premixing: Add the organosilicon-modified acrylic resin obtained in Preparation Example 3 into water, stir for 30 minutes, and disperse evenly; then add urea peroxide, sodium monofluorophosphate, potassium nitrate and PVP, and continue stirring for 30 minutes under a vacuum condition of -0.08 to -0.1 MPa to obtain a premixed solution;

[0079] Preparation of gel: dissolve sodium hydroxide in water to prepare a 10wt% catalytic solution; under vacuum conditions of -0.08 to -0.1MPa, drop the catalyst solution into the premixed solution and stir for 40 minutes; finally, degas the solution under vacuum and stirring to prepare a teeth whitening gel.

[0080] Table 1, Examples 1 to 3 Raw material ratio (kg)

[0081]

[0082] Example 4 is a teeth whitening gel, which is different from Example 1 in that an equal amount of the organosilicon-modified acrylic resin obtained in Preparation Example 4 is used to replace the organosilicon-modified acrylic resin obtained in Preparation Example 1.

[0083] Example 5, a teeth whitening gel, is different from Example 1 in that an equal amount of the organosilicon-modified acrylic resin obtained in Preparation Example 5 is used to replace the organosilicon-modified acrylic resin obtained in Preparation Example 1.

[0084] Example 6 is a teeth whitening gel, which is different from Example 5 in that an equal amount of polyvinyl alcohol is used as the viscosity enhancer to replace polyvinyl pyrrolidone.

[0085] Example 7, a teeth whitening gel, is different from Example 5 in that 0.8 kg of an accelerator is also added to the raw materials and added together with the silicone-modified acrylic resin in the premixing step. The accelerator is specifically PEG-10 polydimethylsiloxane.

[0086] Example 8, a teeth whitening gel, is different from Example 5 in that 1.8 kg of an accelerator is also added to the raw materials and added together with the silicone-modified acrylic resin in the premixing step. The accelerator is specifically lauryl PEG-8 polydimethylsiloxane.

[0087] Comparative Example

[0088] Comparative Example 1 is a teeth whitening gel, which is different from Example 1 in that an equal amount of polyvinyl pyrrolidone is used as the binder to replace the organosilicon-modified acrylic resin obtained in Preparation Example 1.

[0089] Comparative Example 2 is a teeth whitening gel, which is different from Example 1 in that an equal amount of polyvinyl alcohol is used as the binder to replace the silicone-modified acrylic resin obtained in Preparation Example 1.

[0090] Comparative Example 3, a teeth whitening gel, 1g of sodium tripolyphosphate is dissolved in 5mL of deionized water, and fully dissolved using a magnetic stirrer at a speed of 300-350r / min, and stirred for 5-10min to form an activator, and then fully reacted with 1.2g of potassium permonosulfate, and then 0.8g of sodium alginate is added and mixed, and the mixture is stirred evenly and allowed to stand to obtain the activator.

[0091] Performance testing

[0092] 1. Release performance of gel active ingredients

[0093] In an indoor environment with a temperature of 25±1℃, apply the tooth whitening gel to the frosted glass surface to make a gel strip with a length of 10cm, a width of 3cm, and a thickness of 5mm. Then immerse the sample with the gel strip in a beaker filled with 1L of deionized water, and the frosted glass should be parallel to the beaker wall. Monitor the change of peroxide concentration in the water from the beginning of sample immersion, and measure the concentration at 5min, 30min, 1h, and 2h using an RQflex reflectometer.

[0094] After 2 hours, the gel strip was dissolved in ethyl acetate, and the dissolved gel was added to the above beaker and stirred evenly. The total peroxide concentration of the gel was measured, and the concentration dissolution rate (the value of the peroxide concentration in water to the total concentration) at each measuring time point was calculated.

[0095] 2. Gel whitening performance

[0096] Maxillary premolars extracted for orthodontic treatment within 30 days were selected, and the color difference (L* value) of the tooth surface was measured using a spectrocolorimeter. The teeth were then immersed and wrapped in whitening gel, immersed at 37±1℃ for 2 hours, and then taken out and the color difference (L* value) of the tooth surface was measured using a spectrocolorimeter. The whitening effect was evaluated based on the difference (△L) in the L* value before and after the immersion treatment.

[0097] 3. Gel stability

[0098] 100 ml of the whitening gel from each embodiment and comparative example was taken and put into a glass bottle. The glass bottle was placed in a constant temperature box at 50° C. and left to stand for 7 days to observe whether the gel had stratification.

[0099] Table 2. Experimental results

[0100]

[0101] Experimental results analysis:

[0102] (1) It can be seen from Examples 1 to 8 and Comparative Examples 1 to 3 and Table 2 that, compared with the use of a hydrophilic film-forming agent, the present application uses a silicone acrylic resin, which can reduce the dissolution and dilution rate of the whitening active ingredient (peroxide) while ensuring the migration rate of the active ingredient, desensitizer and other ingredients to the tooth surface to a certain extent, thereby ensuring the teeth whitening effect.

[0103] (2) It can be seen from Example 1 and Example 4 and Table 2 that the present application uses a step-by-step polymerization process to enrich the silicone monomer on the surface of the resin particles, which is beneficial to improving the hydrophobicity of the resin and reducing the phenomenon of effective ingredients being dissolved and diluted by saliva. The content of effective ingredients that migrate to the tooth surface can be increased, thereby improving the whitening effect on teeth.

[0104] (3) Combining Example 1 and Example 5 with Table 2, it can be seen that in the preparation process of the organosilicon-modified acrylic resin, the use of methoxy-terminated silicone oil and the polymer product can significantly reduce the dissolution and dilution rate of the active ingredient. On the one hand, it can reduce the dissolution and dilution of the active ingredient by saliva, and on the other hand, the release rate of the active ingredient to the tooth surface matches the tooth bleaching speed, giving full play to the whitening effect of peroxide and improving the whitening effect.

[0105] (4) It can be seen from Example 1 and Example 6 and Table 2 that the present application uses polyvinyl alcohol as a viscosity enhancer, which is beneficial to improving the precipitation and stratification problem caused by the addition of methoxy-terminated silicone oil, preventing the silicone oil from being enriched on the gel surface and affecting the migration of the effective ingredients to the tooth surface, thereby facilitating the whitening effect on teeth.

[0106] (5) It can be seen from Example 1 and Examples 7 and 8 and Table 2 that the present application adopts PEG-10 polydimethylsiloxane or lauryl PEG-8 polydimethylsiloxane, which has a silicone-silicon segment and a hydrophilic segment, and can act as a migration medium, promote the full dissolution of the active ingredients, compensate for the problem of decreased total dissolution rate of the active ingredients caused by the introduction of silicone oil and silicone segments, and effectively improve the whitening effect.

[0107] This specific embodiment is merely an explanation of the present application and is not a limitation of the present application. After reading this specification, those skilled in the art may make modifications to the present embodiment without any creative contribution as needed, but such modifications are protected by the patent law as long as they are within the scope of the claims of the present application.

Claims

1. A tooth whitening gel, characterized in that: The invention comprises the following raw materials in parts by weight: Peroxide: 5-10%; Binder: 20-40%; Thickener: 5-10%; Desensitizer: 0.5-2%; Catalyst: 0.01~0.1%; Water: balance; The adhesive is silicone-modified acrylic resin; The catalyst is used to catalyze the peroxide reaction; In parts by weight, the polymerizable monomers of the organosilicon-modified acrylic resin include: Soft monomer: 40-50 parts; Hard monomer: 30-40 parts; Unsaturated silicone monomer: 10-20 parts; The soft monomer is selected from one or a combination of acrylic acid, hydroxyethyl acrylate, ethyl acrylate, and butyl acrylate; The hard monomer is selected from one or a combination of styrene, acrylonitrile, methyl acrylate, and methyl methacrylate; The unsaturated silicone monomer is selected from one or a combination of vinyltrimethoxysilane, octamethylcyclotetrasiloxane and methacryloxypropyltrimethoxysilane; The preparation method of the organosilicon-modified acrylic resin is as follows: Emulsification: adding soft monomer, hard monomer and at least 50 wt% of unsaturated silicone monomer to the emulsifier solution, dispersing evenly to obtain an emulsion; Core layer polymerization: add the emulsion into sodium bicarbonate buffer, heat to 75-88°C, stir evenly, then add at least 90wt% of initiator solution, stir and react to obtain a core layer polymerization product; Shell polymerization: add the remaining unsaturated silicone monomer and initiator solution to the core polymerization product, stir and react, and after the reaction is completed, cool and cool to obtain silicone-modified acrylic resin.

2. A tooth whitening gel according to claim 1, characterized in that: The peroxide is selected from one or a combination of hydrogen peroxide, sodium percarbonate, calcium peroxide, urea peroxide, persulfate, and perborate.

3. A tooth whitening gel according to claim 1, characterized in that: The desensitizing agent is selected from one or a combination of strontium chloride, potassium nitrate and sodium monofluorophosphate.

4. A tooth whitening gel according to claim 1, characterized in that: The viscosity enhancer is selected from one or a combination of polyvinyl pyrrolidone, sorbitol, hydroxyethyl cellulose, sodium carboxymethyl cellulose, sodium alginate, gelatin, xanthan gum, and polyvinyl alcohol.

5. A tooth whitening gel according to claim 1, characterized in that: In the shell polymer step, after the reaction is completed, a methoxy-terminated silicone oil with a viscosity of 30 to 100 cp is added, and the mass ratio of the methoxy-terminated silicone oil to the unsaturated silicone monomer is 5 to 15:10 to 20. The molecular structure of the methoxy-terminated silicone oil is as follows: 。 6. A tooth whitening gel according to claim 1, characterized in that: The tackifier is polyvinyl alcohol.

7. A tooth whitening gel according to claim 1, characterized in that: The raw materials also include 0.5-2% of an accelerator, and the accelerator is PEG-10 polydimethylsiloxane or lauryl PEG-8 polydimethylsiloxane.

8. The method for preparing a tooth whitening gel according to any one of claims 1 to 6, characterized in that: The steps include: Premixing: Add the organosilicon-modified acrylic resin into water, disperse evenly, then add peroxide, desensitizer and tackifier, mix evenly under vacuum conditions to obtain a premixed solution; Gel preparation: Dissolve the catalyst in water and add it dropwise into the premixed liquid for dispersion and degassing to prepare the teeth whitening gel.

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