Washing needle assembly and medical device

Abstract

This invention provides a washing needle assembly and medical device, relating to the field of medical device technology, including a base, an aspiration needle, and an injection needle; the injection needle includes an injection needle tip, the bottom end of which forms an injection outlet; the injection outlet is located above the aspiration inlet; the plane where the injection outlet is located is a first plane, and the angle between the first plane and the axis of the injection needle is α; the steps of injection, aspiration, and cleaning of the aspiration needle can be completed in the same sequence, saving space in the washing tray layout and time occupied by the washing needle assembly; furthermore, the cleaning of the aspiration needle is completed simultaneously during the injection process, resulting in a shorter washing time; in addition, there is no need to set up an additional cleaning structure for cleaning the aspiration needle, which simplifies the structure of the washing needle assembly, reduces the complexity of the washing needle assembly structure, thereby reducing the risk of experimental errors and reducing costs.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, and in particular to a washing needle assembly and medical device. Background Technology

[0002] In detection equipment, such as nucleic acid detection devices, chemiluminescence immunoassay devices, and multiplex detectors, the detection process requires the aspiration and injection of corresponding samples or reagents through appropriate needle components to facilitate sample washing or transfer. Taking the cleaning step of magnetic beads during the detection process as an example... Figure 18 As shown, in the existing cleaning process, the washing solution is first injected through the injection needle 1'. After injection, the injection needle 1' is moved to another position. The suction needle 2' is moved to the corresponding position in the reaction tube to clean the magnetic beads. After cleaning, the magnetic beads 4' are adsorbed onto the side wall of the reaction tube. At this time, the washing solution in the reaction tube is aspirated through the suction needle 2', completing the cleaning step. To avoid contamination carried by the suction needle 2', it is necessary to move the suction needle 2' to the cleaning structure 5' for cleaning.

[0003] Therefore, during the nucleic acid testing process, both the injection needle 1′ and the aspiration needle 2′ are used separately, occupying two time positions. The cleaning structure 5′ also occupies one time position when cleaning the aspiration needle 2′, resulting in the washing needle occupying a lot of time. Furthermore, since each step is completed cumulatively according to the time sequence, the washing process takes a long time. Summary of the Invention

[0004] The purpose of this invention is to provide a washing needle assembly to solve the technical problems of existing technologies, such as the large amount of time occupied by the washing needles, the long washing process time, and the high structural complexity.

[0005] The washing needle assembly provided by the present invention includes a base, a suction needle, and an injection needle;

[0006] The aspiration needle and the injection needle are respectively mounted on the base, and the injection needle is located on one side of the aspiration needle;

[0007] The aspiration needle includes an aspiration needle tip, the bottom end of which forms an aspiration inlet; the injection needle includes an injection needle tip, the bottom end of which forms an injection outlet; the injection outlet is located above the aspiration inlet.

[0008] The plane where the injection outlet is located is a first plane, the angle between the first plane and the axis of the injection needle is α, and the injection outlet is inclined toward the side wall of the aspiration needle.

[0009] In the vertical direction, the height of the aspiration needle tip is S1, and the distance between the aspiration inlet and the injection outlet is S2; in the horizontal direction, the distance between the axis of the injection needle and the axis of the aspiration inlet is D; the injection time of the injection needle is t.

[0010]

[0011] Furthermore, the aspiration needle also includes an aspiration tube body;

[0012] The aspiration needle tip is connected to the aspiration tube body, and the axial direction of the aspiration tube body and the axial direction of the aspiration needle tip are respectively parallel to the axial direction of the injection needle.

[0013] The outer diameter of the suction tube and the outer diameter of the injection needle are both d4; D = d4.

[0014] Furthermore, the aspiration needle tip includes a first tube and a second tube that are connected to each other;

[0015] The aspiration needle also includes an aspiration tube body; the aspiration tube body, the first tube body, and the second tube body are connected in sequence;

[0016] The axial direction of the suction tube and the axial direction of the first tube are respectively parallel to the axial direction of the injection needle, and the axial direction of the second tube is inclined to the axial direction of the injection needle.

[0017] The outer diameter of both the suction tube and the injection needle is d4; the angle between the axis of the first tube and the axis of the second tube is... In the vertical direction, the height of the first tube is S3; the outer diameter of the second tube is d5.

[0018] Furthermore, the washing needle assembly is used to extend into the reaction cup;

[0019] In the horizontal direction, the distance between the liquid inlet and the inner wall of the reaction cup is L2, 0mm < L2 < 1.5mm.

[0020] Furthermore, 25°≤a≤45°.

[0021] Furthermore, the aspiration needle also includes an aspiration tube body;

[0022] The aspiration needle tip includes a needle tip portion and a variable diameter portion; the aspiration tube body, the variable diameter portion, and the needle tip portion are connected in sequence;

[0023] From the top to the bottom of the variable diameter section, the inner diameter of the variable diameter section gradually decreases;

[0024] The inner diameter of the needle tip is smaller than the inner diameter of the suction tube body, and the wall thickness of the suction needle tip is equal to the wall thickness of the suction tube body.

[0025] Furthermore, the bottom surface of the aspiration needle tip is provided with a plurality of grooves, which are spaced apart circumferentially along the aspiration needle tip; along the extending direction of the grooves, the grooves penetrate the sidewall of the aspiration needle tip.

[0026] Furthermore, the area of ​​the liquid inlet is A2, the longitudinal cross-sectional area of ​​each groove is E, and the number of grooves is n, where n×E=A2.

[0027] Furthermore, the washing needle assembly is used to extend into the reaction cup;

[0028] In the horizontal direction, the distance between the injection needle and the inner wall of the reaction cup is L1, where L1 > 1 mm; in the vertical direction, the liquid height in the reaction cup is h1, where S2 - h1 > 3 mm.

[0029] Another objective of this invention is to provide a medical device, including the washing needle assembly provided by this invention.

[0030] The washing needle assembly provided by this invention includes a base, a suction needle, and an injection needle. The suction needle and the injection needle are respectively disposed on the base, and the injection needle is disposed on one side of the suction needle. The suction needle includes a suction needle tip, and the bottom end of the suction needle tip forms a suction inlet. The injection needle includes an injection needle tip, and the bottom end of the injection needle tip forms an injection outlet. The injection outlet is located above the suction inlet. The plane on which the injection outlet is located is a first plane, and the angle between the first plane and the axis of the injection needle is α. The injection outlet is inclined toward the side wall of the suction needle. In the vertical direction, the height of the suction needle tip is S1, and the distance between the suction inlet and the injection outlet is S2. In the horizontal direction, the distance between the axis of the injection needle and the axis of the suction inlet is D. The injection time of the injection needle is t. During the magnetic bead cleaning process of the reaction cup, liquid enters the injection needle through the injection inlet and flows out through the injection outlet. After flowing out of the injection outlet, the liquid flows to the side wall of the suction needle and then flows into the reaction cup along the side wall. Simultaneously, the liquid is injected into the reaction cup, and the bottom of the suction needle is also cleaned, preventing contamination from being carried by the suction needle. The injection process and the cleaning of the suction needle bottom are performed simultaneously. Then, the suction inlet draws waste liquid from the reaction cup into the suction needle, and the waste liquid is discharged from the suction outlet, completing the suction process. The washing needle assembly provided by this invention can complete the injection, suction, and cleaning of the suction needle in the same sequence, saving space in the washing tray layout and time occupied by the washing needle assembly. Furthermore, the cleaning of the suction needle is completed simultaneously during the injection process, resulting in a shorter washing time. In addition, no additional cleaning structure is needed to clean the suction needle, simplifying the structure of the washing needle assembly, reducing its complexity, thereby reducing the risk of experimental errors and lowering costs. Attached Figure Description

[0031] To more clearly illustrate the specific embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the specific embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of the present invention. For those skilled in the art, other drawings can be obtained from these drawings without creative effort.

[0032] Figure 1 This is a schematic diagram of the structure of a washing needle assembly with a direct suction needle provided in an embodiment of the present invention;

[0033] Figure 2 This is a schematic diagram of the structure of a washing needle assembly with a side-suction liquid aspiration needle provided in an embodiment of the present invention;

[0034] Figure 3 This is a cross-sectional view of a washing needle assembly with a direct suction needle provided in an embodiment of the present invention;

[0035] Figure 4 This is a cross-sectional view of a washing needle assembly with a side-suction aspiration needle provided in an embodiment of the present invention;

[0036] Figure 5 This is a partial schematic diagram of a washing needle assembly with a direct suction needle provided in an embodiment of the present invention;

[0037] Figure 6 This is a partial schematic diagram of a washing needle assembly with a side-suction aspiration needle provided in an embodiment of the present invention;

[0038] Figure 7 yes Figure 3 Enlarged view of point A in the middle;

[0039] Figure 8 yes Figure 4 Enlarged view of point B in the middle;

[0040] Figure 9 This is a usage diagram of the washing needle assembly with a direct suction needle provided in an embodiment of the present invention;

[0041] Figure 10 This is a usage diagram of the washing needle assembly with a side-suction liquid aspiration needle provided in an embodiment of the present invention;

[0042] Figure 11 This is a schematic diagram of a washing needle assembly with a direct suction needle aspirating needle aspirating residual liquid in a reaction cup provided in an embodiment of the present invention;

[0043] Figure 12 This is a top view of the reaction cup being aspirated by the washing needle assembly with a direct suction needle provided in an embodiment of the present invention;

[0044] Figure 13 This is a schematic diagram of a washing needle assembly with a side-suction aspiration needle aspirating needle provided in an embodiment of the present invention aspirating residual liquid in a reaction cup;

[0045] Figure 14 This is a top view of the washing needle assembly with a side-suction aspiration needle provided in an embodiment of the present invention, which aspirates liquid from a reaction cup.

[0046] Figure 15 This is a graph showing the relationship between the amount of residual liquid Q3 and S in the washing needle assembly with a side-suction suction needle provided in this embodiment of the invention.

[0047] Figure 16 This is a simplified timing diagram of a washing needle assembly with a direct suction needle provided in an embodiment of the present invention;

[0048] Figure 17 This is a simplified timing diagram of a washing needle assembly with a side-suction aspiration needle provided in an embodiment of the present invention;

[0049] Figure 18 This is a timing diagram of the washing needle in the prior art.

[0050] Icons: 1-Aspiration needle; 11-Aspiration inlet; 12-Aspiration outlet; 13-Aspiration tube body; 14-Aspiration needle tip; 141-Groove; 142-First tube body; 143-Second tube body; 144-Reducing diameter section; 145-Needle tip; 2-Sleeve; 3-First pagoda connector; 4-Second pagoda connector; 5-Base; 51-Connecting port; 6-Injection needle; 61-Injection inlet; 62-Injection outlet; 7-Magnetic bead; 8-Reaction cup; 81-Center position; 9-Residual liquid; 1'-Injection needle; 2'-Aspiration needle; 3'-Reaction cup; 4'-Magnetic bead; 5'-Cleaning structure. Detailed Implementation

[0051] The technical solution of the present invention will now be clearly and completely described with reference to the accompanying drawings. Obviously, the described embodiments are only some, not all, of the embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0052] This invention provides a washing needle assembly and a medical device. Several embodiments are given below to describe the washing needle assembly and medical device provided by this invention in detail.

[0053] Example 1

[0054] The washing needle assembly provided in this embodiment, such as Figures 1 to 17 As shown, the device includes a base 5, a suction needle 1, and an injection needle 6. The suction needle 1 and the injection needle 6 are respectively disposed on the base 5, and the injection needle 6 is disposed on one side of the suction needle 1. The suction needle 1 includes a suction needle tip 14, and the bottom end of the suction needle tip 14 forms a suction inlet 11. The injection needle 6 includes an injection needle tip 6, and the bottom end of the injection needle tip 6 forms an injection outlet 62. The injection outlet 62 is located above the suction inlet 11. The plane in which the injection outlet 62 is located is a first plane, and the angle between the first plane and the axis of the injection needle 6 is α. The injection outlet 62 is inclined toward the side wall of the suction needle 1. In the vertical direction, the height of the suction needle tip 14 is S1, and the distance between the suction inlet 11 and the injection outlet 62 is S2. In the horizontal direction, the distance between the axis of the injection needle 6 and the axis of the suction inlet 11 is D. The injection time of the injection needle 6 is t.

[0055]

[0056] During the cleaning process of magnetic beads 7 in reaction vessel 8, such as Figures 3 to 4 As shown, liquid enters the injection needle 6 through the injection inlet 61 and flows out through the injection outlet 62. After flowing out of the injection outlet 62, the liquid flows to the side wall of the suction needle 1 and flows into the reaction cup 8 along the side wall of the suction needle 1. At the same time as the liquid is injected into the reaction cup 8, the tip 14 of the suction needle is also cleaned to prevent the suction needle 1 from carrying contamination. The liquid injection process and the cleaning process of the suction needle tip 14 are carried out simultaneously. Then, the suction inlet 11 draws the waste liquid in the reaction cup 8 into the suction needle 1, and then the waste liquid is discharged from the suction outlet 12 of the suction needle 1, completing the liquid suction process.

[0057] The washing needle assembly provided in this embodiment, such as Figures 16 to 17As shown, the steps of liquid injection, liquid aspiration, and cleaning of the aspiration needle 1 can be completed at the same time position, saving the layout space of the washing tray and the time occupied by the washing needle assembly; in addition, the operation of cleaning the aspiration needle 1 is completed simultaneously during the liquid injection process, so that the washing process takes less time; furthermore, there is no need to set up an additional cleaning structure to clean the aspiration needle 1, which simplifies the structure of the washing needle assembly, reduces the complexity of the washing needle assembly structure, thereby reducing the risk of experimental errors and reducing costs.

[0058] During the cleaning process of the suction needle tip 14, when the liquid flows out from the injection outlet 62, the injection angle of the injection outlet 62 is &1, the injection speed of the injection outlet 62 is V1, the area of ​​the injection outlet 62 is A1, and the injection volume of the injection outlet 62 is Q1; when the liquid flows out from the suction inlet 11, the injection angle of the suction inlet 11 is &2, the injection speed of the suction inlet 11 is V2, the area of ​​the suction inlet 11 is A2, and the injection volume of the suction inlet 11 is Q2. The fluid submerges the tip of the suction needle 1, and the splashing and beading phenomena are relatively weak.

[0059] The specific calculation method is as follows:

[0060] According to the continuity equation: V1A1=V2A2=constant; Q1=Q2=Q; Conditions for use: steady flow: the fluid is incompressible and there are no air bubbles in the fluid;

[0061] Therefore:

[0062] A1=(πd12) / (4cosa); A2=(πd22) / 4; Q1=(V1πd12) /

[0063] (4cosa); Q2=(V2πd22) / 4; where, the inner diameter of the injection needle 6 is d1; the inner diameter of the suction inlet 11 is d2;

[0064] The injection volume Q is the target set value, and the pump injection speed V is... t The target setpoint is the injection time t.

[0065] Horizontal direction: The entire area of ​​the aspiration needle tip 14 must be flushed within the specified time t;

[0066] Along the horizontal direction, the distance between the axis of the injection needle 6 and the axis of the aspiration inlet 11 is D, where D is the target selection design value;

[0067] Therefore: D = V t ×cosa×t;V t =D / (cosa×t);

[0068] Vertical direction: The injection and aspiration needle tip 14 must be covered within the specified time t;

[0069] In the vertical direction, the height of the aspiration needle tip 14 is S1, and the distance between the aspiration inlet 11 and the injection outlet 62 is S2. S1 and S2 are the set and modified values ​​according to actual use requirements.

[0070] Therefore:

[0071]

[0072]

[0073]

[0074] Therefore:

[0075] Where g is the acceleration due to gravity.

[0076] exist At that time, the liquid flowing out of the injection outlet 62 can effectively cover the suction needle tip 14, thereby cleaning the suction needle tip 14 and giving it a good cleaning effect.

[0077] Specifically, such as Figures 1 to 2 As shown, the inner and outer surfaces of the suction needle 1 and the injection needle 6 require vacuum coating to prevent liquid from adhering to their inner and outer surfaces. The suction needle 1 passes through the base 5 and is fixedly mounted on the base 5. The bottom of the suction needle 1 forms a suction inlet 11, and the top of the suction needle 1 is provided with a first pagoda connector 3. The top of the first pagoda connector 3 forms a suction outlet 12. The size of the first pagoda connector 3 can be designed according to the inner diameter of the tubing used. The injection needle 6 passes through the base 5 and is fixedly mounted on the base 5. The bottom of the injection needle 6 forms an injection outlet 62, and the top of the injection needle 6 is provided with a second pagoda connector 4. The top of the second pagoda connector 4 forms an injection inlet 61. The size of the second pagoda connector 4 can be designed according to the inner diameter of the tubing used. The base 5, suction needle 1, injection needle 6, first pagoda connector 3, and second pagoda connector 4 are all made of non-magnetic material.

[0078] Vacuum coating can be applied to any suitable hydrophobic material, such as Teflon. Furthermore, the inner and outer surfaces of the suction needle 1 can be polished with absolute high precision to prevent liquid from adhering to the inner and outer surfaces of both the suction needle 1 and the injection needle 6.

[0079] Furthermore, the base 5 includes a sleeve 2; the sleeve 2 is fixedly sleeved on the outside of the suction needle 1 and the injection needle 6.

[0080] The sleeve 2 can be fixed to the top surface of the base 5, the bottom surface of the base 5, or any other suitable position. In this embodiment, the sleeve 2 is fixed to the bottom surface of the base 5, with the washing needle and the injection needle 6 in contact with each other. The sleeve 2 wraps around the outside of the suction needle 1 and the injection needle 6 to position them. The sleeve 2 restricts the movement of the suction needle 1 and the injection needle 6, ensuring they are stably positioned on the base 5. When the suction needle 1 and the injection needle 6 move vertically, the sleeve 2 provides stable and reliable movement, acting as a buffer and protection.

[0081] The aspiration needle 1 can be a direct aspiration needle 1 or a side aspiration needle 1.

[0082] When the aspiration needle 1 is a direct aspiration type aspiration needle 1, such as Figure 3 As shown, the aspiration needle 1 also includes an aspiration tube body 13; the aspiration needle tip 14 is connected to the aspiration tube body 13, and the axial direction of the aspiration tube body 13 and the axial direction of the aspiration needle tip 14 are respectively parallel to the axial direction of the injection needle 6; the outer diameter of the aspiration tube body 13 and the outer diameter of the injection needle 6 are both d4; D = d4.

[0083] The distance between the axis of the injection needle 6 and the axis of the aspiration inlet 11 is D.

[0084] Specifically, the suction tube body 13 is positioned above the suction needle tip 14. The axes of the injection needle 6, the suction needle tip 14, and the suction tube body 13 are all vertically aligned. The bottom end of the suction needle tip 14 forms a suction inlet 11. The suction tube body 13 is fitted snugly against the injection needle 6. After the suction needle 1 extends into the reaction cup 8, the suction inlet 11 faces the bottom wall of the reaction cup 8. The inner diameter of the injection needle 6 is d1.

[0085] like Figure 5 As shown, the injection speed is controlled during the cleaning process of the direct suction needle 1.

[0086]

[0087] Q1=(V1πd12) / (4cosa);

[0088] V1=(4cosaQ1) / (πd12);

[0089] cos & 1=(cosa×V) t / V1)=(π×d1 2 ×d4) / (4cosa×Q1×t);

[0090] &1=arccos[(π×d1 2 [×d4) / (4cosa×Q1×t)];

[0091] Expected target results;

[0092] &2≈90°;

[0093] V²≈4Q² / πd² 2 .

[0094] When the aspiration needle 1 is a side-suction type aspiration needle 1, such as Figure 4 As shown, the aspiration needle tip 14 includes a first tube 142 and a second tube 143 connected to each other; the aspiration needle 1 also includes an aspiration tube body 13; the aspiration tube body 13, the first tube 142, and the second tube 143 are connected in sequence; the axial direction of the aspiration tube body 13 and the axial direction of the first tube 142 are respectively parallel to the axial direction of the injection needle 6, and the axial direction of the second tube 143 is inclined to the axial direction of the injection needle 6; the outer diameter of the aspiration tube body 13 and the outer diameter of the injection needle 6 are both d4; the angle between the axis of the first tube 142 and the axis of the second tube 143 is θ. In the vertical direction, the height of the first tube 142 is S3; the outer diameter of the second tube 143 is d5.

[0095] Specifically, the aspiration tube body 13 is positioned above the aspiration needle tip 14. The axis of the injection needle 6 and the axis of the aspiration tube body 13 are both arranged vertically. The first tube body 142 and the second tube body 143 form the needle tip 145. In the horizontal direction, the bottom end of the second tube body 143 is deflected toward one side of the axis of the aspiration tube body 13. The bottom end of the second tube body 143 forms the aspiration inlet 11. After the aspiration needle 1 is inserted into the reaction cup 8, the aspiration inlet 11 is positioned toward the side wall of the reaction cup 8. The aspiration tube body 13 is fitted with the injection needle 6. The inner diameter of the injection needle 6 is d1.

[0096] The distance between the axis of the injection needle 6 and the axis of the aspiration inlet 11 is D.

[0097] like Figure 6 As shown, the injection speed is controlled during the cleaning process of the side-suction aspiration needle 1.

[0098] Q1=(V1πd12) / (4cosa);

[0099] V1=(4cosaQ1) / (πd12);

[0100]

[0101]

[0102] Expected target results;

[0103]

[0104] V²≈4Q² / πd² 2 .

[0105] Due to V t =D / (cosa×t), the smaller a is, the faster the pump injection rate V. t The larger the value of 'a', the easier it is for the liquid flowing from the injection outlet 62 to cover the suction needle tip 14, thereby cleaning the suction needle tip 14 and achieving a good cleaning effect. However, considering the actual situation and usage conditions, when 'a' ≤ 45°, the liquid flowing from the injection outlet 62 can effectively cover the suction needle tip 14 and clean it thoroughly.

[0106] Furthermore, the aspiration needle 1 also includes an aspiration tube body 13; the aspiration needle tip 14 includes a needle tip portion 145 and a reducing portion 144; the aspiration tube body 13, the reducing portion 144 and the needle tip portion 145 are connected in sequence; from the top to the bottom of the reducing portion 144, the inner diameter of the reducing portion 144 gradually decreases; the inner diameter of the needle tip portion 145 is smaller than the inner diameter of the aspiration tube body 13, and the wall thickness of the aspiration needle tip 14 is equal to the wall thickness of the aspiration tube body 13.

[0107] Specifically, along the vertical direction, the inner and outer diameters of the variable diameter section 144 gradually decrease from top to bottom, and the wall thickness of the needle tip 145 is equal to the wall thickness of the variable diameter section 144; wherein, the inner diameter of the suction tube body 13 is d3, the outer diameter of the suction tube body 13 is d4, the inner diameter of the needle tip 145 is d2, the outer diameter of the needle tip 145 is d5, and the wall thickness of the suction needle tip 14 is equal to the wall thickness of the suction tube body 13, that is, d4-d3=d5-d2.

[0108] The variable diameter section 144 is provided so that the inner diameter of the needle tip 145 is smaller than the inner diameter of the suction tube body 13, and the outer diameter of the needle tip 145 is smaller than the outer diameter of the suction tube body 13. This reduces the liquid adhesion surface of the suction needle tip 14, reduces the rinsing surface of the suction needle tip 14, reduces the beading surface of the suction needle tip 14, and increases the liquid suction force of the suction needle tip 14.

[0109] Furthermore, the bottom surface of the aspiration needle tip 14 is provided with a plurality of grooves 141, which are spaced apart along the circumference of the aspiration needle tip 14; along the extending direction of the grooves 141, the grooves 141 penetrate the sidewall of the aspiration needle tip 14.

[0110] After the washing needle assembly is inserted into the reaction cup 8, when the liquid inlet 11 is close to the bottom wall of the reaction cup 8, the liquid inlet 11 has a small liquid flow rate. The liquid can enter the liquid inlet 1 through the groove 141 to reduce the amount of liquid residue.

[0111] In this embodiment, there are four grooves 141, which are evenly spaced along the circumference of the liquid-absorbing needle tip 14.

[0112] Furthermore, the area of ​​the liquid inlet 11 is A2, the longitudinal cross-sectional area of ​​each groove 141 is E, the number of grooves 141 is n, and n×E=A2.

[0113] The sum of the longitudinal cross-sectional areas of the multiple grooves 141 is made equal to the area of ​​the liquid inlet 11, so that when the liquid enters the liquid needle 1 through the grooves 141, the liquid inlet area of ​​the multiple grooves 141 is equal to the area of ​​the liquid inlet 11, ensuring that the liquid has a sufficient liquid inlet area to enter the liquid suction tube.

[0114] In this embodiment, the inner diameter of the liquid inlet 11 is d2, and A2 = (πd2²) / 4; the depth of the groove 141 in the vertical direction is h; and the width of the groove 141 in the horizontal direction is b, and E = h × b. In this embodiment, n = 4, and b ≥ 0.2 mm.

[0115] Furthermore, the washing needle assembly is used to extend into the reaction cup 8; in the horizontal direction, the distance between the injection needle 6 and the inner wall of the reaction cup 8 is L1, where L1 > 1 mm; in the vertical direction, the liquid height inside the reaction cup 8 is h1, where S2 - h1 > 3 mm.

[0116] Among them, such as Figure 9 As shown, the direct suction needle 1 is used for cleaning the round-bottom reaction cup 8. The washing needle assembly is required to have a liquid level detection function. It is connected to the detection PCB through the wiring port 51 on the base 5. When the suction needle 1 moves downward, it starts to suction liquid when it contacts the liquid surface. The distance between the injection needle 6 and the inner wall of the reaction cup 8 is L1, where L1 > 1 mm, to avoid contamination between the reaction cup 8 and the injection needle 6. The liquid height in the reaction cup 8 is h1, and the height difference between the suction inlet 11 and the injection outlet 62 is S2, where S2 - h1 > 3 mm, to prevent the liquid in the reaction cup 8 from splashing up, thereby avoiding contamination between the reaction cup 8 and the injection needle 6.

[0117] And, as Figure 9 As shown, the distance between the bottom of the injection needle 6 and the opening of the reaction cup 8 in the vertical direction is h2, h2>3mm, so as to avoid the liquid in the reaction cup 8 being splashed up, thereby avoiding contamination between the reaction cup 8 and the injection needle 6.

[0118] like Figure 10As shown, the side-suction aspiration needle 1 is used for cleaning the flat-bottomed reaction cup 8. The washing needle assembly is required to have a liquid level detection function. It is connected to the detection PCB through the wiring port 51 on the base 5. When the aspiration needle 1 moves downward, it starts to aspirate liquid when it contacts the liquid surface. The distance between the injection needle 6 and the inner wall of the reaction cup 8 is L1, where L1 > 1 mm, to avoid contamination between the reaction cup 8 and the injection needle 6. The liquid height in the reaction cup 8 is h1, and the height difference between the aspiration inlet 11 and the injection outlet 62 is S2, where S2 - h1 > 3 mm, to prevent the liquid in the reaction cup 8 from splashing up, thereby avoiding contamination between the reaction cup 8 and the injection needle 6.

[0119] And, as Figure 10 As shown, the distance between the bottom of the injection needle 6 and the opening of the reaction cup 8 in the vertical direction is h2, h2>3mm, so as to avoid the liquid in the reaction cup 8 being splashed up, thereby avoiding contamination between the reaction cup 8 and the injection needle 6.

[0120] Furthermore, when the side-suction aspiration needle 1 is used to clean the flat-bottomed reaction cup 8, the distance between the aspiration inlet 11 and the inner wall of the reaction cup 8 in the horizontal direction is L2, 0mm < L2 < 1.5mm.

[0121] When the side-suction aspiration needle 1 is used for cleaning the flat-bottomed reaction cup 8, the magnetic bead 7 is set on the side wall of the reaction cup 8, and the aspiration inlet 11 is set opposite to the magnetic bead 7. The distance between the aspiration inlet 11 and the inner side wall of the reaction cup 8 is set to L2, 0mm < L2 < 1.5mm, which can prevent the aspiration needle 1 from scratching the side wall of the reaction cup 8.

[0122] like Figure 11 As shown, the direct suction needle 1 is matched with the round bottom reaction cup 8, which can effectively control the amount of residual liquid. It can meet the requirement that the residual liquid 9Q3 < 5.0ul. When the direct suction needle 1 is located at the center position 81 of the round bottom reaction cup 8, the residual liquid 9 is minimized.

[0123] The volume of the wash solution was 600 μL. The solution was aspirated using a round-bottom reaction cup 8 and a direct-suction aspiration needle 1 located at the center of the round-bottom reaction cup 8. The results of the residual test after 4 injections and 4 aspirations are shown in Table 1.

[0124] Table 1

[0125]

[0126] The cleaning test method for injection needle 6 is as follows:

[0127] Add the test liquid to the round-bottom reaction cup 8, and use the direct suction needle 1 to draw up the test liquid. After drawing up the liquid, return the test liquid to the round-bottom reaction cup 8. Take a new round-bottom reaction cup 8. The reaction cup 8 is dry and free of contamination. Move the direct suction washing needle above the new round-bottom reaction cup 8, and use the injection needle 6 to inject clean water to clean the suction needle 1. After cleaning, analyze the concentration of the test liquid in the new round-bottom reaction cup 8.

[0128] The test results for different cutting angles 'a' of injection needle 6 are shown in Table 2.

[0129] Table 2

[0130] Injection needle tangent angle Inject clean water volume Concentration in the new reaction tube The injection needle has a 10-degree incision angle. 600ul 11.20％ The injection needle is at a 15-degree angle. 600ul 19.80％ The injection needle has a 20-degree incision angle. 600ul 25.40％ The injection needle is at a 25-degree angle. 600ul 38.90％ The injection needle has a 30-degree incision angle. 600ul 40.30％ The injection needle is at a 35-degree angle. 600ul 40.30％ The injection needle has a 40-degree incision angle. 600ul 40.80％ The injection needle is at a 45-degree angle. 600ul 41.70％ The injection needle is at a 50-degree angle. 600ul 23.50％ The injection needle is at a 55-degree angle. 600ul 21.60％ The injection needle has a 60-degree tangential angle. 600ul 20.10％

[0131] After liquid injection and aspiration residue test: when the direct aspiration needle 1 is located at the center position 81 of the round bottom reaction cup 8 for liquid aspiration and the size of the aspiration needle 1 is basically the same, the average value of the aspiration residue is <3.0ul.

[0132] The cleaning test is conducted using the injection needle 6. After the aspiration needle 1 draws up the liquid to be tested, the liquid is injected back into the reaction cup 8. Then, the aspiration needle 1 is placed above the new reaction cup 8, and the aspiration needle 1 is rinsed with clean water. The concentration of the liquid to be tested in the new reaction cup 8 reflects the cleaning effect of the aspiration needle 1. The cleaner the aspiration needle 1 is cleaned, the greater the amount of liquid to be tested that is rinsed from the aspiration needle 1 into the new reaction cup 8, and the higher the concentration of the liquid to be tested in the new reaction cup 8.

[0133] Therefore, by analyzing the experimental data in Table 2, it can be seen that when the tangent angle of the injection needle 6 is 25°≤a≤45°, the concentration of the test liquid in the new reaction cup 8 is relatively high, and the cleaning effect on the aspiration needle 1 is better.

[0134] like Figure 12 As shown, the side-suction aspiration needle 1 is matched with the flat-bottomed reaction cup 8. The magnetic beads 7 or magnetic sheets are set on the inner side wall of the reaction cup 8. The aspiration inlet 11 is set opposite to the magnetic beads 7. The aspiration inlet 11 will not attract the magnetic beads 7 or magnetic sheets, which can effectively reduce the wear of the magnetic beads 7 or magnetic sheets. In addition, the aspiration inlet 11 descends with the liquid level in the reaction cup 8, causing less disturbance to the liquid surface, thereby improving the aspiration effect and effectively controlling the amount of aspirated liquid residue. It can meet the requirement that the aspirated liquid residue 9Q3 < 5.0ul. In the horizontal direction, when the distance between the aspiration inlet 11 and the magnetic beads 7 is S, the aspirated liquid residue 9 is minimized, and S ≥ 0.5mm.

[0135] The inner diameter of reaction cup 8 is D1, and the distance between the liquid inlet 11 and the inner wall of reaction cup 8 in the horizontal direction is...

[0136] The volume of the wash solution was 600 μL. A flat-bottomed reaction cup 8 was used. The distance between the liquid inlet 11 and the magnetic bead 7 was S in the horizontal direction. The results of the residual test after 4 liquid injections and 4 liquid aspirations are shown in Table 3.

[0137] Table 3

[0138]

[0139] The cleaning test method for injection needle 6 is as follows:

[0140] Add the test liquid to the flat-bottomed reaction cup 8, and use the side-suction needle 1 to draw up the test liquid. After drawing up the liquid, return the test liquid to the flat-bottomed reaction cup 8. Take a new flat-bottomed reaction cup 8. The reaction cup 8 is dry and free of contamination. Move the side-suction washing needle above the new flat-bottomed reaction cup 8, and use the injection needle 6 to inject clean water to clean the suction needle 1. After cleaning, analyze the concentration of the test liquid in the new flat-bottomed reaction cup 8.

[0141] The test results for different cutting angles 'a' of injection needle 6 are shown in Table 4.

[0142] Table 4

[0143] Injection needle tangent angle Inject clean water volume Concentration in the new reaction tube The injection needle has a 10-degree incision angle. 600ul 17.50％ The injection needle is at a 15-degree angle. 600ul 24.60％ The injection needle has a 20-degree incision angle. 600ul 35.70％ The injection needle is at a 25-degree angle. 600ul 49.90％ The injection needle has a 30-degree incision angle. 600ul 51.10％ The injection needle is at a 35-degree angle. 600ul 51.30％ The injection needle has a 40-degree incision angle. 600ul 52.40％ The injection needle is at a 45-degree angle. 600ul 52.80％ The injection needle is at a 50-degree angle. 600ul 36.10％ The injection needle is at a 55-degree angle. 600ul 30.70％ The injection needle has a 60-degree tangential angle. 600ul 27.30％

[0144] After liquid injection and aspiration residue test: along the horizontal direction, with the distance between the aspiration inlet 11 and the magnetic bead 7 being S and the dimensions of the aspiration needles 1 being basically the same, the average value of aspiration residue is <3.0ul.

[0145] The cleaning test is conducted using the injection needle 6. After the aspiration needle 1 draws up the liquid to be tested, the liquid is injected back into the reaction cup 8. Then, the aspiration needle 1 is placed above the new reaction cup 8, and the aspiration needle 1 is rinsed with clean water. The concentration of the liquid to be tested in the new reaction cup 8 reflects the cleaning effect of the aspiration needle 1. The cleaner the aspiration needle 1 is cleaned, the greater the amount of liquid to be tested that is rinsed from the aspiration needle 1 into the new reaction cup 8, and the higher the concentration of the liquid to be tested in the new reaction cup 8.

[0146] Therefore, by analyzing the experimental data in Table 4, it can be seen that when the tangent angle of the injection needle 6 is 25°≤a≤45°, the concentration of the test liquid in the new reaction cup 8 is relatively high, and the cleaning effect on the aspiration needle 1 is better.

[0147] Example 2

[0148] The medical device provided in this embodiment includes the washing needle assembly provided in Embodiment 1. During the cleaning process of the magnetic beads 7 in the reaction cup 8, such as... Figures 3 to 4As shown, liquid enters the injection needle 6 through the injection inlet 61 and flows out through the injection outlet 62. After flowing out of the injection outlet 62, the liquid flows to the side wall of the suction needle 1 and flows into the reaction cup 8 along the side wall of the suction needle 1. At the same time as the liquid is injected into the reaction cup 8, the bottom of the suction needle 1 is also cleaned to prevent the suction needle 1 from carrying contamination. The liquid injection process and the cleaning process of the bottom of the suction needle 1 are carried out simultaneously. Then, the suction inlet 11 draws the waste liquid in the reaction cup 8 into the suction needle 1, and then the waste liquid is discharged from the suction outlet 12 of the suction needle 1, completing the liquid suction process.

[0149] The medical device provided in this embodiment can complete the steps of injection, aspiration, and cleaning of the aspiration needle 1 at the same time position, saving the layout space of the washing tray and the time occupied by the washing needle assembly; in addition, the cleaning operation of the aspiration needle 1 is completed simultaneously during the injection process, so that the washing process takes less time; furthermore, there is no need to set up an additional cleaning structure to clean the aspiration needle 1, which can simplify the structure of the washing needle assembly, reduce the complexity of the washing needle assembly structure, thereby reducing the risk of experimental errors and reducing costs.

[0150] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, and not to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some or all of the technical features; and these modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A wash needle assembly characterized by, The washing needle assembly comprises a base, a liquid suction needle and a liquid injection needle; The liquid suction needle and the liquid injection needle are arranged on the base, and the liquid injection needle is arranged on one side of the liquid suction needle; The liquid suction needle comprises a liquid suction needle tip, and a bottom end of the liquid suction needle tip forms a liquid suction inlet; the liquid injection needle comprises a liquid injection needle tip, and a bottom end of the liquid suction needle tip forms a liquid injection outlet; the liquid injection outlet is located above the liquid suction inlet; The plane where the liquid injection outlet is located is a first plane, an included angle between the first plane and an axis of the liquid injection needle is a, and the liquid injection outlet is arranged to be inclined to a side wall of the liquid suction needle; In a vertical direction, a height of the liquid suction needle tip is S1, and a height difference between the liquid suction inlet and the liquid injection outlet is S2; in a horizontal direction, a distance between the axis of the liquid injection needle and an axis of the liquid suction inlet is D; and a liquid injection time of the liquid injection needle is t; a = arctan [ (S2 - S1 gt 2 ) / D] ; The liquid suction needle tip comprises a first tube body and a second tube body which are connected to each other; The liquid suction needle further comprises a liquid suction tube body; the liquid suction tube body, the first tube body and the second tube body are connected in sequence; An axial direction of the liquid suction tube body and an axial direction of the first tube body are arranged in parallel to an axial direction of the liquid injection needle, and an axial direction of the second tube body is arranged to be inclined to the axial direction of the liquid injection needle; An outer diameter of the liquid suction tube body and an outer diameter of the liquid injection needle are both d4; an included angle between the axis of the first tube body and the axis of the second tube body is Ø; in a vertical direction, a height of the first tube body is S3; and an outer diameter of the second tube body is d5; D = cot(180° - Θ) x S3+ d4- d5.

2. The wash needle assembly of claim 1, wherein, The washing needle assembly is used to extend into a reaction cup; In a horizontal direction, a distance between the liquid suction inlet and an inner side wall of the reaction cup is L2, and 0mm < L2 < 1.5mm.

3. The wash needle assembly of claim 1, wherein, 25°≤a≤45°。 4. The washing needle assembly according to claim 1, wherein The liquid suction needle tip comprises a needle tip part and a variable-diameter part; the liquid suction tube body, the variable-diameter part and the needle tip part are connected in sequence; and the first tube body and the second tube body form the needle tip part; From a top of the variable-diameter part to a bottom of the variable-diameter part, an inner diameter of the variable-diameter part is tapered; an inner diameter of the needle tip part is smaller than an inner diameter of the liquid suction tube body, and a wall thickness of the liquid suction needle tip is equal to a wall thickness of the liquid suction tube body.

5. The wash needle assembly of claim 1, wherein, A bottom surface of the liquid suction needle tip is provided with a plurality of grooves which are arranged in a circumferential direction of the liquid suction needle tip in a spaced manner; and in an extension direction of the grooves, the grooves are arranged to penetrate through a side wall of the liquid suction needle tip.

6. The wash needle assembly of claim 5, wherein, An area of the liquid suction inlet is A2, a longitudinal sectional area of each of the grooves is E, and the number of the grooves is n, and n x E = A2.

7. The wash needle assembly of claim 1, wherein, The washing needle assembly is used to extend into a reaction cup; In a horizontal direction, a distance between the liquid injection needle and an inner side wall of the reaction cup is L1, and L1 > 1mm; and in a vertical direction, a liquid height in the reaction cup is h1, and S2 - h1 > 3mm.

8. A medical device, characterized by The washing needle assembly comprises the washing needle assembly according to any one of claims 1-7.

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