High-efficiency Immunoassay Analyzer

Abstract

The present invention discloses an efficient immunoassay analyzer, which includes a frame and a conveying channel hung on one side of the frame. The conveying channel includes a channel body having at least one sampling channel. The sampling channel is sequentially provided with a buffer position and a sampling position along its conveying direction. A buffer gripper and a sampling gripper are respectively arranged on the channel body corresponding to the buffer position area and the sampling position. Both the buffer gripper and the sampling gripper can reciprocally slide along the sampling channel. Among them, the buffer gripper can send the sample rack located at the inlet end of the sampling channel to the buffer position in a pushing or / and pulling manner, and the sampling gripper can position and hold the sample rack located at the buffer position at the sampling position in a pushing or / and pulling manner. A sample filling system is arranged on the frame corresponding to the sampling position. It can improve the sampling accuracy and reduce the error rate. Combining with the new incubation system, dilution system and the structural layout of the corresponding grippers, etc., starting from aspects such as shortening the turnover steps and cycle and exhausting the working efficiency of components, the detection efficiency of the analyzer is improved.

Description

Technical Field

[0001] The present invention belongs to the field of medical devices, and particularly relates to an efficient immunoassay analyzer. Background Art

[0002] In the process of centralized in vitro diagnosis, samples gathered together usually need to be sent to a detection and analysis device for detection and analysis in sequence or by category. This transportation process is completed by a conveying channel. There are various types of existing conveying channel structures. The conveying channel can be directly placed beside the analysis device or directly hung on the analysis device. For example, the document number is "CN217332496U", and the patent name is "Sample Scheduling System". Its system can assemble a conveying module, a supply and recovery module, and a buffer scheduling module according to different sample scheduling requirements, with high versatility; and the patent with the document number "CN 207036878U" and the patent name "Sample Rack Conveying Device in a Sample Transmission System".

[0003] However, currently, the conveying channels basically use synchronous belts for direct transmission and are combined with position sensors for positioning. The applicant found during the research process that since the sample rack being conveyed and the synchronous belt rely entirely on friction to drive, and are also affected by the tension of the synchronous belt, it directly leads to difficult precise positioning of the sample rack at each position. Moreover, the inner diameter of the sample tube on the sample rack is relatively small. When the position of the sample rack is inaccurate, it will directly affect the sampling accuracy of the sample needle in the analysis device. It is very likely that the sample needle deviates from the actual sample bottle mouth, resulting in sampling failure or incorrect sampling, etc., which is likely to reduce the detection efficiency and detection quality. In addition, since most samples need to be diluted with reagents during the detection process, and the layout between the dilution system structure and other modules on the analyzer is unreasonable, it directly leads to a reduction in dilution efficiency and also affects the overall detection efficiency of the analyzer. Summary of the Invention

[0004] In view of this, the present invention provides an efficient immunoassay analyzer to solve the problems in the prior art that the positioning of the sample rack in the conveying channel supporting the analyzer is inaccurate, the sampling position accuracy is poor, which is likely to lead to sampling failure, and the distribution of modules such as the dilution system on the analyzer is unreasonable, thereby reducing the detection efficiency.

[0005] The technical solution is as follows:

[0006] An efficient immunoassay analyzer includes a frame and a conveying channel hung on one side of the frame. The conveying channel includes a channel main body having at least one sampling channel. The key lies in that: the sampling channel is sequentially provided with a buffer position and a sampling position along its conveying direction. A buffer gripper and a sampling gripper are respectively arranged on the channel main body corresponding to the buffer position area and the sampling position. Both the buffer gripper and the sampling gripper can reciprocally slide along the sampling channel. Among them, the buffer gripper can send the sample rack located at the inlet end of the sampling channel to the buffer position in a pushing or / and pulling manner. The sampling gripper can position and hold the sample rack located at the buffer position at the sampling position in a pushing or / and pulling manner. A sample filling system is arranged on the frame corresponding to the sampling position. The sample filling system includes at least two sample filling modules, and each sample filling module has a sample filling needle.

[0007] With the above solution, compared with the traditional way of directly driving by the friction between the sample rack and the conveyor belt, in this application, the sample rack is directly conveyed in place by the gripper in a pushing and pulling manner. When the power stops, the drive stops, realizing the precise positioning of the sample rack at the sampling position, ensuring that the sample filling system can successfully take samples, thereby indirectly improving the operation efficiency of the analyzer. The two sample needles perform cross-sampling in space to meet the requirements of direct sample addition and dilution sample addition, which is beneficial to further improving the efficiency.

[0008] Preferably: the sampling gripper includes a hook frame, a sampling drive mechanism for driving the hook frame to move along the conveying direction of the sampling channel, and an orbit switching mechanism for driving the hook frame to move along a direction perpendicular to the conveying direction of the sampling channel. Among them, the hook frame includes a frame body arranged along the conveying direction of the sampling channel, and a fixed claw and a movable claw respectively arranged at both ends of the frame body. The extending directions of the fixed claw and the movable claw are both perpendicular to the conveying direction of the sampling channel. The fixed claw is close to the outlet end of the sampling channel, and the movable claw can rotate towards the end where the fixed claw is located. With the above sampling gripper structure, the movable claw does not prevent the sample rack from entering the sampling position. By using the cooperation of the fixed claw and the movable claw and moving back and forth, the precise positioning of the sample rack can be quickly realized. And by using the orbit switching mechanism, the orbit switching of the sampling gripper can be realized to prevent interference with the outflow of the sample rack.

[0009] Preferably, the sampling gripper further includes a sampling gripper seat. The track switching mechanism includes a variable track guide rail and a variable track guiding component. The variable track guide rail is perpendicular to the conveying direction of the sampling channel. The frame is slidably matched with the variable track guide rail. A return spring is provided between the frame and the sampling gripper seat, and the return spring is arranged parallel to the variable track guide rail. In the initial state, under the action of the return spring, at least part of the fixed claw and the movable claw extend into the sampling channel. With the above solution, the fixed claw and the movable claw can better fit the front and rear end faces of the sample rack to achieve pushing and pulling, prevent slipping or skewing of the sample rack, improve the reliability of the sampling gripper, and simplify the structure for easy implementation. The return spring can keep the sampling gripper in the sampling channel at all times when waiting, and will not prevent the sample rack from entering between the movable claw and the fixed claw.

[0010] Preferably, the variable track guiding component includes a follower arranged on the hook claw frame and a guide arranged on the sampling channel. When the sampling gripper moves towards the outlet end of the sampling channel and exceeds the sampling position, the follower and the guide can cooperate to guide the hook claw frame to move away from the sampling channel, and the fixed claw and the movable claw withdraw from the sampling channel. With the above solution, the use of a passive structure for cooperation and guidance is beneficial to reducing the implementation cost and facilitating later maintenance and replacement.

[0011] Preferably, the sampling gripper seat is located below the sampling channel. The bottom wall of the sampling channel has a sliding window for the fixed claw and the movable claw to extend into and slide. The follower is a roller, and the axis of the roller is perpendicular to the length direction of the sampling channel.

[0012] The guide includes two baffles arranged on one side of the sampling channel in a deflectable manner and an avoidance track located below the sampling channel. The two baffles are distributed along the length direction of the sampling channel and are located at the front and rear ends of the avoidance track. The roller and the baffle have a spatially overlapping part in the width direction of the sampling channel. With the above solution, compared with setting the sampling gripper seat on one side of the sampling channel, the occupancy of the width space of the entire conveying unit can be reduced, and only the occupancy of a certain height space is increased. The original space layout under the sampling channel only has a support structure, and its space utilization is relatively more reasonable.

[0013] Preferably, the machine frame includes an upper layer of the machine frame. An incubation system is provided near the middle position on the upper layer of the machine frame. The sample addition system is located between the incubation system and the conveying channel. The incubation system includes an incubation module and a filling ring rotatably arranged on the circumferential outer side of the incubation module. The filling ring has filling reaction cup placement holes arranged in a circumferential array. By integrating the filling ring in the incubation system, the filling ring, as a transfer component, is connected to multiple modules on the analyzer by rotation, which can effectively shorten the transfer distance between two adjacent modules and shorten the turnover time, and is beneficial to further improving the detection efficiency.

[0014] Preferably, the incubation system comprises an incubation base, the incubation module is rotatably supported on the incubation base, and the incubation base is provided with an incubation tray rotating motor and a filling ring rotating motor for driving the incubation module and the filling ring to rotate respectively.

[0015] Preferably, a dilution system is provided between the sample filling system and the incubation system, the dilution system comprising a dilution channel module and a dilution mixing module distributed at an angle, wherein the dilution channel module comprises a dilution trolley translation assembly and a dilution needle group lifting assembly, and the dilution trolley translation assembly comprises a dilution translation channel and a dilution trolley slidably matched with the dilution translation channel;

[0016] The dilution and mixing module includes a mixing rack and a stirring assembly arranged on the mixing rack, the stirring assembly includes a stirring rod and a dilution and mixing lifting assembly and a dilution and mixing translation assembly respectively used to drive the stirring rod to lift and translate, and a stirring motor for driving the stirring rod to rotate, and the translation path of the dilution trolley and the translation path of the stirring rod have an intersection. By adopting the above scheme, the dilution channel module and the dilution and mixing module can be better arranged on the analytical instrument to achieve modular installation, and at the same time, the dilution uniformity effect can be improved by using the stirring method after the diluent is added, thereby improving the accuracy of subsequent detection.

[0017] Preferably, the mixing rack is arranged in parallel with the conveying channel, at least one washing system is arranged on the upper layer of the rack, the dilution translation channel is located between the incubation system and one of the washing systems, and a second transfer gripper is arranged between the washing system and the incubation system, and the moving track of the second transfer gripper is directly opposite to the rotation center of the incubation module. The dilution system adopts such a layout, which can further improve the space utilization rate of the analyzer, and at the same time shorten the transfer cycle between the washing system and the incubation module. The second transfer gripper is used to realize the transfer of the reaction cup in the washing system, and can also be used for the cup dropping operation of the reaction cup in the dilution system, thereby improving the utilization efficiency of the second transfer gripper.

[0018] Preferably, the upper layer of the rack is provided with a reaction cup loading system, the reaction cup loading system comprises a cup discharging module, a cup row channel module and a cup separation module, and the washing system has two;

[0019] The cup discharging module is located near a corner of the upper layer of the rack, the cup dispensing module is located between the two washing systems, and a first transfer gripper is provided between the cup dispensing module and the incubation system, and there is an intersection between the first transfer gripper and the dilution translation channel, which is the loading and unloading position of the reaction cup in the dilution channel, and the moving tracks of the first transfer gripper and the second transfer gripper are both facing the rotation center of the incubation module. The above scheme is adopted to improve the space utilization efficiency. At the same time, by utilizing the space intersection arrangement, the first transfer gripper can improve the loading efficiency of the reaction cup on the filling ring, while taking into account the loading and unloading efficiency of the reaction cup in the dilution system, that is, it can also be used to grab and discard the reaction cup in the dilution channel, making full use of the gripper function, which is conducive to simplifying the overall structure.

[0020] Compared with the prior art, the present invention has the following beneficial effects:

[0021] The high-efficiency immunoassay analyzer provided by the present invention is used in conjunction with an optimized delivery channel to improve sampling accuracy and reduce the error rate. At the same time, a new incubation system, a dilution system and a corresponding gripper structure layout are combined to shorten the turnover steps and cycles, maximize the working efficiency of components, etc., thereby improving the detection efficiency of the analyzer and shortening the single detection time. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 It is a structural schematic diagram of the present invention;

[0023] Figure 2 for Figure 1 axonometric drawing;

[0024] Figure 3 It is a schematic diagram of the structure and principle of the present invention;

[0025] Figure 4 It is a schematic diagram of the structure of the conveying channel;

[0026] Figure 5 for Figure 4 Stereogram;

[0027] Figure 6 It is a schematic diagram of the structure of the sampling drive mechanism and the track switching mechanism;

[0028] Figure 7 for Figure 6 Side view of

[0029] Figure 8 for Figure 7 A top view of

[0030] Figure 9 This is a schematic diagram of the sampling gripper structure;

[0031] Figure 10 This is a working diagram of the track switching mechanism;

[0032] Figure 11 is Figure 10 the corresponding three-dimensional view;

[0033] Figure 12 is the schematic structural diagram of the incubation system;

[0034] Figure 13 is the schematic structural diagram of the filling ring installation;

[0035] Figure 14 is Figure 13 the sectional view of;

[0036] Figure 15 is the three-dimensional view of the dilution system (the dilution trolley is in the dilution / waste liquid suction position);

[0037] Figure 16 is Figure 15 the axonometric view of (the dilution trolley is in the dilution and mixing position);

[0038] Figure 17 is the schematic structural diagram of the sample filling system;

[0039] Figure 18 is the schematic structural diagram of the sample filling module;

[0040] Figure 19 is the schematic structural diagram of the reaction cup loading system. Specific Embodiments

[0041] The present invention will be further described in detail below with reference to the accompanying drawings.

[0042] Referring to Figures 1 to 19 the shown high-efficiency immunoassay analyzer, which includes a frame 100, and a conveying channel R hung on one side of the frame 100. The conveying channel R is usually hung on the frame 100 by a snap suspension method, or can be directly supported on the same support surface as the frame 100 through a support structure. A sample filling system is provided on the frame 100, and the conveying channel R is mainly used to receive the incoming sample rack and convey it to a position close to the frame 100 for the sample filling system to take samples for detection.

[0043] As shown in the figure, the conveying channel R mainly includes a channel main body R200. At least one sampling channel R210 is provided on the channel main body R200. The bottom of the sampling channel R210 is plate-shaped or a slideway structure, and both sides have side plates. The side plates and the bottom enclose to form the sampling channel R200, and both ends and the top are open.

[0044] In this application, a buffer position and a sampling position are sequentially arranged along the conveying direction of the sampling channel R210. A buffer gripper R300 and a sampling gripper R400 are respectively arranged on the channel body R200 corresponding to the buffer position and the sampling position. Both the buffer gripper R300 and the sampling gripper R400 can reciprocally slide along the sampling channel R210. Among them, the buffer gripper R300 can push and / or pull the sample rack located at the inlet end of the sampling channel R210 to the buffer position, and the sampling gripper R400 can push and / or pull the sample rack located at the buffer position to be positioned and held at the sampling position.

[0045] Specifically as shown in the figure, the sampling gripper R400 mainly includes a claw frame R410, a sampling driving mechanism R420 for driving the claw frame R410 to move along the conveying direction of the sampling channel R210, and a track switching mechanism for driving the claw frame R410 to move along a direction perpendicular to the conveying direction of the sampling channel R210 (the direction from the inlet end to the outlet end).

[0046] Among them, the claw frame R410 includes a frame body R411 arranged along the conveying direction of the sampling channel R210, and a fixed claw R412 and a movable claw R413 respectively arranged at both ends of the frame body R411. The extending directions of the fixed claw R412 and the movable claw R413 are both perpendicular to the conveying direction of the sampling channel R210. Among them, the fixed claw R412 is close to the outlet end of the sampling channel R210, and the movable claw R413 can rotate towards the end where the fixed claw R412 is located.

[0047] Focus on Figure 9 Specifically in implementation, the movable claw R413 is installed at the end of the frame body R411 through a torsion spring, and a limit protrusion R414 is correspondingly arranged. In the initial state, the movable claw R413 abuts against the limit protrusion R414 under the action of the torsion spring and is in a relative state with the fixed claw R412. The side of the movable claw R413 facing away from the fixed claw R412 has an inclined guiding surface. When the inclined guiding surface is subjected to pressure, its upper end rotates towards the end where the fixed claw R412 is located, and will not interfere with the components behind.

[0048] To facilitate the further precise positioning of the sample rack at the sampling position, the linear distance between the fixed claw R412 and the movable claw R413 is greater than the length of the supporting sample rack. In this way, during the movement of the sampling gripper R400, both the fixed claw R412 and the movable claw R413 can respectively push the sample rack to adjust its position.

[0049] In this application, the track switching mechanism is mainly used to drive the fixed claw R412 and the movable claw R413 out of the internal space range of the sampling channel R210 to avoid interfering with the movement of the sample rack.

[0050] As shown in the figure, the sampling gripper R400 further includes a sampling gripper seat R430. The gripper seat R430 is mainly used to carry the hook frame R410. The track switching mechanism includes a variable track guide R431 and a variable track guiding component. The variable track guide R431 is perpendicular to the conveying direction of the sampling channel R210, and is mainly used to guide the hook frame R410 to move stably in the direction of approaching or departing from the sampling channel R210. Therefore, the frame body R411 is slidably engaged with the variable track guide R431, and a return spring R432 is provided between the frame body R411 and the sampling gripper seat R430, and the return spring R432 is arranged in parallel with the variable track guide R431. In the initial state, under the action of the return spring R432, the frame body R411 is in the position closest to the sampling channel R210, and both the fixed claw R412 and the movable claw R413 extend into the sampling channel R210.

[0051] The variable track guiding component includes a follower R433 arranged on the hook frame R410 and a guiding member arranged on the sampling channel R210. When the sampling gripper R400 moves towards the outlet end direction of the sampling channel R210 and exceeds the sampling position, the follower R433 and the guiding member can cooperate to guide the hook frame R410 to move away from the sampling channel R210, and the fixed claw R412 and the movable claw R413 withdraw from the sampling channel R210 area.

[0052] As shown in the figure, in this embodiment, the sampling gripper seat R430 is located below the sampling channel R210. The variable track guide R431 and the return spring R432 are both vertically arranged on the gripper seat R430, on one side of the gripper seat R430, and the upper and lower ends of the gripper seat R430 have protruding parts for limiting the lifting stroke of the hook frame R410. The hook frame R410 is in the upper dead position under the action of the return spring R432.

[0053] The bottom wall of the sampling channel R210 has a sliding window R211 for the fixed claw R412 and the movable claw R413 to extend into and slide. The follower R433 is a roller, and the roller is rotatably installed on the frame body R411, and the axis of the roller is perpendicular to the length direction of the sampling channel R210.

[0054] The guiding member includes two baffles R434 arranged on one side of the sampling channel R210 in a deflectable manner and an avoidance track R435 located below the sampling channel R210. As shown in the figure, the two baffles R434 are distributed along the length direction of the sampling channel R210 and are located at the front and rear ends of the avoidance track R435. The roller and the baffle R434 have a spatially overlapping part in the width direction of the sampling channel R210. Specifically, the baffle R434 is also installed at the lower side position of the sampling channel R210 through a torsion spring.

[0055] Focus on reference Figure 10 and Figure 11The baffle R434 is generally in an obtuse V-shape, including a front baffle R4340 and a rear baffle R4341 (in this embodiment, the front and rear are both based on the inlet end of the sampling channel R210 as a reference, the closer one is the front, and the farther one is the rear), hereinafter referred to as the first baffle close to the front end of the sampling channel R210, and the other is the second baffle. In the initial state, under the action of the torsion spring, the front baffle R4340 of the first baffle sinks and is located below the avoidance track R435 and the roller, and the rear baffle R4341 is upturned and located on the translation path of the roller, and the front baffle R4340 of the second baffle is basically flush with or slightly lower than the avoidance track R435, and its rear baffle R4341 is upturned and also located on the translation path of the roller, and its highest point is flush with or slightly higher than the high point of the roller.

[0056] When the sampling gripper R400 moves toward the end of the sampling channel R210, the roller can easily pass over the first baffle and the second baffle. After passing over, the first baffle and the second baffle are reset. When the sampling gripper R400 returns to move toward the front end of the sampling channel R210, the roller contacts the back side of the rear stop R4341 of the second baffle, and is guided by it to indirectly apply a downward guiding force to the frame R411. The frame R411 compresses the reset spring R432 and moves downward until the roller contacts the surface of the avoidance track R435.

[0057] The sampling gripper R400 moves toward the front end of the sampling channel R210, and when the roller contacts the back side of the first baffle, the first baffle can be rotated and lifted clockwise without hindering the forward movement of the sampling gripper R400. At this time, when the roller passes over the first baffle forward, the first baffle is reset again, and the frame body R411 is also reset to the upper stop position under the action of the reset spring R432, returning to the initial state, and the fixed claw R412 and the movable claw R413 are both extended into the sampling channel, so that the sample rack can be pushed and pulled for positioning.

[0058] In this embodiment, the follower R433 adopts a roller structure, which can improve the sliding smoothness. Of course, a fixed protrusion structure can also be directly adopted, which is within the protection scope of this application.

[0059] The sampling drive mechanism R420 mainly includes a sampling motor R421 and a sampling positioning belt R422 and a sampling guide rail R423 arranged along the length direction of the sampling channel R210. A sampling slider R436 that slides with the sampling guide rail R423 is provided on the gripper seat R430 on the side away from the frame R411, and the gripper seat R430 is fixedly connected to the sampling positioning belt R422 at the same time.

[0060] It should be noted that the sampling gripper R400 can also be arranged on one side of the sampling channel R210, that is, the frame R411 is located on one side of the sampling channel R210. The fixed claw R412 and the movable claw R413 are both horizontally arranged and protrude above the sampling channel R210 along the width direction of the sampling channel R210. Correspondingly, the track-changing guide rail R431 and the return spring R432 are both arranged along the width direction of the sampling channel R210, while the avoidance guide rail R435 and the similar guiding part structure are arranged on the side of the sampling channel R210. Similar solutions are all within the protection scope of this application.

[0061] On the basis of the above embodiments, in order to further ensure the accuracy of the sampling position and the reliability of the pushing and pulling force points of the sampling gripper, a sliding window R211 is opened on the side wall close to the sampling channel R210. At the same time, a side extrusion member R212 corresponding to the sampling position is arranged on one side of the sampling channel R210. The side extrusion member R212 at least partially protrudes into the sampling channel R210 under the action of the torsion spring, and makes the sample rack at the sampling position adhere to the side wall on the opposite side, which can prevent the uncertainty of the relative position between the sample rack and the side wall of the sampling channel at the sampling position, and is more conducive to further realizing the accurate positioning of the sample rack.

[0062] As shown in the figure, the side extrusion member R212 also adopts a roller structure, and its axis is arranged along the height direction of the sampling channel R210. A through hole for the side extrusion member 212 to protrude into the sampling channel R210 is opened on the side wall of the sampling channel R210. By arranging the side extrusion member R212 and the sliding window R211 on opposite sides, the sample rack can be made to be close to the side where the sliding window R211 is opened, which is convenient for the pushing and pulling operation of the sampling gripper R400, and can better ensure the position stability of the sample rack in the sampling channel R210. By using the roller structure to contact the side of the sample rack, the friction force can be reduced to ensure smooth sliding.

[0063] The main function of the buffer gripper R300 is to transport the sample rack sent or prepared by the sample bin unit SU to the middle position of the sampling channel R210. The existence of the buffer hook R300 can reduce the travel of the sampling gripper R400, thereby reducing the movement time of the sampling gripper R400 to improve efficiency. It includes a buffer gripper frame R310 and a buffer driving mechanism R320 for driving the buffer gripper frame R310 to reciprocate along the length direction of the sampling channel R210. Buffer hooks R311 are movably installed at both the front and rear ends of the buffer gripper frame R310 through torsion springs. The buffer hooks R311 are arranged along the width direction of the sampling channel R210 and at least partially extend above the sampling channel R210 to Figure 4For reference, the installation method of the cache hook R311 is similar to that of the movable claw R413. The end thereof protruding to the sampling channel R210 can rotate clockwise toward the outlet end of the sampling channel R210 under the action of the thrust toward the outlet end of the sampling channel R210, but cannot rotate in the opposite direction. When the thrust is eliminated, the cache hook R311 is reset.

[0064] The rotatable directions of the two cache hooks R311 remain consistent, and both have guiding slopes on one side facing the front end of the sampling channel R210, which is more conducive to pushing the sample rack into between the two cache hooks R311, and pulling it out from the rear end cache hook R311 to the sampling position.

[0065] In order to further increase the function of the supply system and meet more diagnostic needs, the channel body R200 also includes an emergency channel R230 and a return channel R220, as well as an emergency positioning gripper and an emergency transfer gripper R240 set for the emergency channel 230, and a return gripper R221 set corresponding to the return channel R220. As shown in the figure, the emergency channel R230, the sampling channel R210 and the return channel R220 are arranged side by side, and the structure of the emergency positioning gripper is similar to that of the sampling gripper R400.

[0066] On the other hand, under normal circumstances, the conveying channel R is used in conjunction with the sample bin unit SU and the recovery unit R500. The sample bin unit SU has a transfer unit SU100. The structure of the above-mentioned emergency transfer gripper R240 is similar to that of the cache gripper R300. The difference is that the moving stroke of the emergency transfer gripper R240 is relatively large. It is mainly used to pull the sample rack into the emergency channel R230 and send it to the emergency sampling position. After the inspection, it is sent to the recovery unit R500. Similarly, a completion gripper R250 is provided near the end of the sampling channel R210. The completion gripper R250 is a single-claw structure, similar to the second half of the cache gripper R300. It is used to push the sample rack that has been inspected in the sampling channel R210 into the recovery unit R500.

[0067] In order to prevent the sample racks in the emergency channel R230 and the sampling channel R210 from being pushed out unexpectedly and unable to be received by the recovery unit R500, a stop structure R260 is provided at the conveying end of the emergency channel R230 and the sampling channel R210. In the initial state, the stop structure R260 at least partially protrudes to the front of the corresponding channel outlet end, forming a blocking state for the channel outlet end, and the blocking state can be released by deflection or sliding.

[0068] Specifically as shown in the figure, the stop structure R260 includes a baffle R261 and a return spring R262 rotatably arranged at the outlet ends of the emergency channel R230 and the sampling channel R210. The baffle R261 is held in a vertical state under the pulling of the return spring R262 to block the outlet ends of the two channels. The rotation fulcrum of the baffle R261 is lower than the bottom wall of the channel, and the return spring R262 is located below the rotation fulcrum. One end of it is fixed to the end of the baffle R261. When the baffle R261 is subjected to a thrust force in the width direction of the channel (in the actual implementation process, the recovery cart R510 in the recovery unit R500 slides in the width direction of the channel to push the upper end of the baffle 261 to rotate), the baffle R261 can rotate to a position lower than the bottom wall of the channel. At this time, the sample rack in the corresponding channel can slide out. When the thrust force is eliminated, the baffle R261 returns to its initial vertical state under the action of the return spring R262.

[0069] As shown in the figure, in this application, the frame 100 mainly includes an upper layer 110 and a lower layer 120 of the frame. The upper layer 110 of the frame is used to install each main module. An incubation system 700 is provided near the middle position thereof. The sample loading system is located between the incubation system 700 and the conveying channel R. The incubation system 700 includes an incubation module 720 and a filling ring 730 rotatably arranged on the circumferential outer side of the incubation module 720. The filling ring 730 has filling reaction cup placement holes distributed in a circumferential array.

[0070] Specific reference Figures 12 to 14 , specifically, the incubation system 700 includes an incubation base 710. The incubation base 710 is fixedly arranged on the upper layer 110 of the frame. The incubation module 720 is rotatably supported on the incubation base 710. The incubation base 710 is provided with an incubation disk rotation motor 721 and a filling ring rotation motor 731 for respectively driving the incubation module 720 and the filling ring 730 to rotate.

[0071] The incubation module 720 mainly includes an incubation disk 722 and an incubation disk heat preservation shell 727 covering the outside of the incubation disk 722. The incubation disk 722 has incubation reaction cup placement holes distributed in a circumferential array, and the distribution density of the filling reaction cup placement holes is the same as that of the incubation reaction cup placement holes, that is, the radian between two adjacent filling reaction cup placement holes is equal to the radian between two adjacent incubation reaction cup placement holes. In this way, it is more convenient to control the filling reaction cup placement hole and the incubation reaction cup placement hole to be in the same radial direction during the rotation process. During implementation, to further reduce the control difficulty of the gripper, the upper surface of the incubation disk 722 is flush with the upper surface of the filling ring 730. The top of the incubation disk heat preservation shell 727 is provided with an incubation loading and unloading hole 728 for the incubation reaction cup to be placed and exposed.

[0072] The incubation base 710 is vertically fixed with a fixed base shaft 711, which is a hollow structure. An incubation tray rotating shaft 712 is rotatably arranged inside it. The incubation module 720 is fixedly supported on the incubation tray rotating shaft 712, and a filling ring synchronous pulley is rotatably arranged outside it, so as to realize the coaxial setting of the incubation tray and the filling ring. A incubation tray support plate 713 is fixedly sleeved on the fixed base shaft 711. The incubation tray support plate 713 is generally in a ring-shaped hollow plate structure. The bottom of the incubation tray heat preservation shell 727 is fixedly connected to the incubation tray support plate 713 by screws. At the same time, the middle part of the incubation tray 722 is fixedly connected to the incubation tray rotating shaft 712 by screws.

[0073] Reference Figure 15 and Figure 16 , in the present application, a dilution system 400 is provided between the sample filling system and the incubation system 700. As shown in the figure, the dilution system 400 includes a dilution channel module 410 and a dilution and mixing module 420 distributed at an angle. The dilution channel module 410 includes a dilution trolley translation assembly 430 and a dilution needle group lifting assembly 460. The dilution trolley translation assembly 430 includes a dilution translation channel 431 and a dilution trolley 432 slidably matched with the dilution translation channel 431. The dilution needle group lifting assembly 460 is used to drive the dilution liquid filling needle 464 and the waste liquid suction needle 461 to lift, and perform corresponding operations on the reaction cups located on the corresponding dilution trolley 432. A dilution translation driving mechanism for driving the dilution trolley 432 to slide along its length direction and stay at a preset position is provided on the dilution trolley translation assembly 430.

[0074] The dilution and mixing module 420 includes a mixing frame 421, and a stirring assembly 440 arranged on the mixing frame 421. The stirring assembly 440 includes a stirring rod 441, a dilution and mixing lifting assembly 442 and a dilution and mixing translation assembly 443 respectively used to drive the stirring rod 441 to lift and translate, and a stirring motor 444 for driving the stirring rod 441 to rotate. The translation path of the dilution trolley 432 and the translation path of the stirring rod 441 have an intersection part.

[0075] The mixing frame 421 is arranged in parallel with the conveying channel R, that is, the translation path of the stirring rod 441 is arranged in parallel with the conveying channel R. At the same time, at least one washing system 800 is provided on the upper layer 110 of the frame. The dilution translation channel 431 is located between the incubation system 700 and one of the washing systems 800, and a second transfer gripper 300b is provided between the washing system 800 and the incubation system 700. The second transfer gripper 300b can interactively transfer the reaction cups on the washing system 800 and the incubation system 700, and at the same time can grab and discard the reaction cups that have completed solid-liquid separation after dilution sampling on the dilution translation channel 431.

[0076] In this application, the stirring rod 441 is also equipped with a cleaning cup 450. As shown in the figure, the cleaning cup 450 is located below the stirring rod 441. When the dilution and mixing translation assembly 443 drives the stirring rod 441 to translate, it can be located directly above the cleaning cup 450 and is driven by the dilution and mixing lifting assembly 442 to extend into the cleaning cup 450 for cleaning. This is mainly used to clean and maintain the stirring rod. The stirring rod 441 extends into the cleaning cup 450 for soaking and cleaning, reducing the risk of the stirring rod 441 carrying contamination. Moreover, during the downward and upward movement of the cleaning process, the stirring rod 441 is in a rotating state, which can further improve the cleaning effect and reduce the carried contamination.

[0077] Combined with Figure 17 and Figure 18 As shown, in this application, to improve the overall working efficiency in cooperation with the dilution system 400, the sample injection system mainly includes a sample injection system base 510, and two sample injection modules 520 provided on the sample injection system base 510. Each sample injection module 520 is equipped with a needle washing module 530. In this application, the sample injection module 520 includes a sample needle base frame 521, a sample needle cantilever 522 provided above the sample needle base frame 521, and a cantilever rotation drive motor 523 and a cantilever lifting motor 524 respectively used to drive the sample needle cantilever 522 to rotate reciprocally and lift. The cantilever rotation drive motor 523 and the cantilever lifting motor 524 are both fixedly provided on the sample needle base frame 521 through a tensioning mechanism 525. A vertically downward sample injection needle 5221 is installed on the sample needle cantilever 522.

[0078] Moreover, the cantilever rotation drive motor 523 drives the sample needle cantilever 522 to rotate, and it can stay at the normal sampling position, emergency sampling position, needle washing position, direct sample addition position (referring to adding the sample directly to the reaction cup on the injection ring 730), and dilution addition (sampling) position (this position intersects with the dilution translation channel 431). Initially, the sample needle cantilever 522 is in the high position. When staying at the normal sampling position or emergency sampling position, it can descend to sample the normal sample or emergency sample in the sample supply system, and then rise and rotate to the direct sample addition position, or rotate to the dilution addition (sampling) position and descend for sample addition operations. After each sample addition is completed, it can rotate to the needle washing position for sample needle cleaning, which can avoid sample cross-contamination and ensure the reliability of detection.

[0079] Refer to Figures 1 to 3 and as well as Figure 19The upper layer 110 of the rack is also provided with a reaction cup loading system 200, which includes a cup discharge module 210, a cup row channel module 220 and a cup separation module 230. There are two washing systems 800, the cup discharge module 210 is close to a corner of the upper layer 110 of the rack, the cup row channel module 220 is arranged along the edge of the upper layer 110 of the rack, and the cup separation module 230 is located between the two washing systems 800, and a first transfer gripper 300a is provided between the cup separation module 230 and the incubation system 700, and there is an intersection between the first transfer gripper 300a and the dilution translation channel 431, which is the loading and unloading position of the dilution channel reaction cup. The first transfer gripper 300a can be used to load the reaction cup in the cup separation module 230 onto the dilution trolley 432 and the filling ring 730 on the dilution channel, and of course, it can also be used to grab the reaction cup of the dilution channel at the intersection and perform a cup dropping operation.

[0080] Therefore, the dilution trolley 432 has at least six stop positions on the dilution translation channel 431: a reaction cup loading position, which is the intersection position with the first transfer gripper 300a, at which the first transfer gripper 300a can place the reaction cup on the dilution trolley 432; a dilution sample filling position, which is the rotation intersection position with the sample filling needle 5221 to complete the sample filling; a dilution mixing position, at which the reaction cup is located directly below the stirring rod 441 and can be mixed; a diluted sample sampling position, which is the same as the diluted sample filling position and returns to this position after mixing; a dilution waste liquid suction position, in which the dilution trolley 432 is located directly below the waste liquid suction needle to complete solid-liquid separation; a dilution reaction cup discarding position, in which the dilution trolley 432 is located at the intersection with the second transfer gripper 300b, and the reaction cup on the dilution trolley 432 is grabbed and discarded by the second transfer gripper 300b, which can also be the reaction cup loading position, and the first transfer gripper 300a is used to grab the reaction cup and move the discarded cup.

[0081] In specific implementation, in order to improve space utilization efficiency, the moving trajectories of the first transfer gripper 300a and the second transfer gripper 300b in this embodiment are both opposite to the rotation center of the incubation module 720, and the moving trajectory of the second transfer gripper 300b is perpendicular to the dilution translation channel 431.

[0082] refer to Figures 1 to 19 The high-efficiency immunoassay analyzer shown in the figure initially stores the sample rack containing the sample bottles in the sample compartment unit SU. After the test begins, the transport unit SU100 sends the sample rack to the sampling channel R210 or the emergency channel R230 according to the diagnosis type. Then the sampling gripper R400 or the emergency positioning gripper positions the sample rack in the corresponding channel to facilitate accurate sampling and testing, thereby reducing the sampling error rate.

[0083] After the sample filling system has completed sampling, the corresponding sample rack is sent into the recycling cart R510 through the completion gripper R250 or the emergency transfer gripper R240. Then, it is pulled into the return channel R220 by the return gripper R221 in the return channel R220, and finally sent to the idle sample bin unit SU by the transfer unit SU100.

[0084] After the sample filling system extracts the sample, it is directly filled into the reaction cups on the dilution cart 432 or the filling ring 730. For example, after filling into the reaction cups on the dilution cart 432, it is diluted and mixed evenly, then aspirated by the sample filling needle 5221 and finally filled into the reaction cups on the filling ring 730. After reagent filling and independent mixing operations, it is sent to the washing system 800 for washing and substrate operations, and then sent back to the incubation tray 722. After incubation, it is sent into the detection system for detection. The entire process uses the incubation tray 722 and the filling ring 730 as intermediate media, and rotates to meet the operation requirements of the corresponding modules, which can greatly shorten the operation cycle and improve the detection efficiency.

[0085] Finally, it should be noted that the above description is only the preferred embodiment of the present invention. Under the inspiration of the present invention, those of ordinary skill in the art can make various similar representations without violating the purpose and claims of the present invention. Such transformations all fall within the protection scope of the present invention.

Claims

1. An efficient immunoassay analyzer, comprising a frame (100) and a conveying channel (R) hung on one side of the frame (100), wherein the conveying channel (R) comprises a channel main body (R200) having at least one sampling channel (R210), and is characterized in that: The sampling channel (R210) is sequentially provided with a buffer position and a sampling position along its conveying direction. A buffer gripper (R300) and a sampling gripper (R400) are respectively arranged on the channel body (R200) corresponding to the buffer position area and the sampling position area. Both the buffer gripper (R300) and the sampling gripper (R400) can reciprocally slide along the sampling channel (R210). Among them, the buffer gripper (R300) can push and / or pull the sample rack located at the inlet end of the sampling channel (R210) to the buffer position, and the sampling gripper (R400) can push and / or pull the sample rack located at the buffer position to be positioned and held at the sampling position. A sample filling system is arranged on the frame (100) corresponding to the sampling position, and the sample filling system includes at least two sample filling modules (520), and each sample filling module (520) has a sample filling needle (5221); The sampling gripper (R400) includes a hook frame (R410), a sampling driving mechanism (R420) for driving the hook frame (R410) to move along the conveying direction of the sampling channel (R210), and a track switching mechanism for driving the hook frame (R410) to move along a direction perpendicular to the conveying direction of the sampling channel (R210). Among them, the hook frame (R410) includes a frame body (R411) arranged along the conveying direction of the sampling channel (R210), and a fixed claw (R412) and a movable claw (R413) respectively arranged at both ends of the frame body (R411). The extending directions of the fixed claw (R412) and the movable claw (R413) are both perpendicular to the conveying direction of the sampling channel (R210). Among them, the fixed claw (R412) is close to the outlet end of the sampling channel (R210), and the movable claw (R413) can rotate towards the end where the fixed claw (R412) is located; The frame (100) includes an upper layer of the frame (110). An incubation system (700) is arranged on the upper layer of the frame (110) near the middle position. The sample filling system is located between the incubation system (700) and the conveying channel (R). The incubation system (700) includes an incubation module (720), and a filling ring (730) rotatably arranged on the circumferential outer side of the incubation module (720). The filling ring (730) has filling reaction cup placement holes distributed in a circumferential array.

2. The high-efficiency immunoassay analyzer according to claim 1, wherein: The sampling gripper (R400) further includes a sampling gripper seat (R430). The track switching mechanism includes a track-changing guide rail (R431) and a track-changing guiding component. The track-changing guide rail (R431) is perpendicular to the conveying direction of the sampling channel (R210). The frame body (R411) is slidably matched with the track-changing guide rail (R431). A return spring (R432) is arranged between the frame body (R411) and the sampling gripper seat (R430), and the return spring (R432) is arranged parallel to the track-changing guide rail (R431). In the initial state, under the action of the return spring (R432), both the fixed claw (R412) and the movable claw (R413) at least partially extend into the sampling channel (R210).

3. The high-efficiency immunoassay analyzer according to claim 2, wherein: The orbit-changing guiding component includes a follower (R433) arranged on the claw holder (R410) and a guiding member arranged on the sampling channel (R210). When the sampling gripper (R400) moves towards the outlet end of the sampling channel (R210) and exceeds the sampling position, the follower (R433) and the guiding member can cooperate to guide the claw holder (R410) to move away from the sampling channel (R210), and the fixed claw (R412) and the movable claw (R413) withdraw from the sampling channel (R210).

4. The high-efficiency immunoassay analyzer according to claim 3, wherein: The sampling gripper seat (R430) is located below the sampling channel (R210). The bottom wall of the sampling channel (R210) has a sliding window (R211) for the fixed claw (R412) and the movable claw (R413) to extend into and slide. The follower (R433) is a roller, and the axis of the roller is perpendicular to the length direction of the sampling channel (R210). The guiding member includes two baffles (R434) arranged on one side of the sampling channel (R210) in a deflectable manner and an avoidance track (R435) located below the sampling channel (R210). The two baffles (R434) are distributed along the length direction of the sampling channel (R210) and are located at the front and rear ends of the avoidance track (R435). The roller and the baffle (R434) have a spatially overlapping part in the width direction of the sampling channel (R210).

5. The high-efficiency immunoassay analyzer according to claim 1, characterized in that: The incubation system (700) includes an incubation base (710). The incubation module (720) is rotatably supported on the incubation base (710), and the incubation base (710) is provided with an incubation disk rotation motor (721) and a filling ring rotation motor (731) for respectively driving the incubation module (720) and the filling ring (730) to rotate.

6. The high-efficiency immunoassay analyzer according to claim 1 or 5, characterized in that: A dilution system (400) is provided between the sample filling system and the incubation system (700). The dilution system (400) includes a dilution channel module (410) and a dilution mixing module (420) distributed at an angle. The dilution channel module (410) includes a dilution trolley translation assembly (430) and a dilution needle group lifting assembly (460). The dilution trolley translation assembly (430) includes a dilution translation channel (431) and a dilution trolley (432) slidably engaged with the dilution translation channel (431). The dilution mixing module (420) includes a mixing rack (421) and a stirring assembly (440) arranged on the mixing rack (421). The stirring assembly (440) includes a stirring rod (441), a dilution mixing lifting assembly (442) and a dilution mixing translation assembly (443) for respectively driving the stirring rod (441) to lift and translate, and a stirring motor (444) for driving the stirring rod (441) to rotate. The translation path of the dilution trolley (432) and the translation path of the stirring rod (441) have an intersection part.

7. The high-efficiency immunoassay analyzer according to claim 6, characterized in that: The mixing rack (421) is arranged parallel to the conveying channel (R). At least one washing system (800) is provided on the upper layer (110) of the rack. The dilution translation channel (431) is located between the incubation system (700) and one of the washing systems (800), and a second transfer gripper (300b) is provided between this washing system (800) and the incubation system (700).

8. The high-efficiency immunoassay analyzer according to claim 7, wherein: A reaction cup loading system (200) is provided on the upper layer (110) of the rack. The reaction cup loading system (200) includes a cup outlet module (210), a cup discharging channel module (220) and a cup dispensing module (230). There are two washing systems (800). The cup outlet module (210) is close to a corner of the upper layer (110) of the rack. The cup dispensing module (230) is located between the two washing systems (800). A first transfer gripper (300a) is provided between the cup dispensing module (230) and the incubation system (700). There is an intersection part between the first transfer gripper (300a) and the dilution translation channel (431), and this intersection part is the loading and unloading position of the reaction cup in the dilution channel. The moving trajectories of both the first transfer gripper (300a) and the second transfer gripper (300b) are directly opposite to the rotation center of the incubation module (720).

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